Centre for Arab Genomic Studies a Division of Sheikh Hamdan Award for Medical Sciences

Centre for Arab Genomic Studies A Division of Sheikh Hamdan Award for Medical Sciences

The Catalogue for Transmission Genetics in Arabs CTGA Database

Orosomucoid 2

Alternative Names Molecular Genetics ORM2 ORM2 gene is located on the long arm of Glycoprotein, Alpha-1-Acid, of Serum, Type 2 chromosome 9 at 9q34.1-q34.3. It consists of six Alpha-1-Acid Glycoprotein, Type 2 exons and five introns. ORM protein is expressed AGP2 by the lever and secreted in the plasma. It is composed of a single polypeptide chain of 183 Record Category amino acids with 45% carbohydrate content and Gene locus 12% sialic acid residues. ORM2 gene differs from ORM1 gene by 32 nucleotide substitutions in the WHO-ICD coding sequence, resulting in 21 amino acid N.B.: Classification not applicable to gene loci. substitutions.

Incidence per 100,000 Live Births In contrast to ORM1 gene, ORM2 gene is N/A to gene loci monomorphic in most populations. The ORM2*M allele is the most common allele among all known OMIM Number ORM2 alleles. 138610 Epidemiology in the Arab World Mode of Inheritance Egypt N/A Sebetan et al. (1997) carried out a study to investigate the genetic variants of the human Gene Map Locus plasma orosomucoid ORM1 and ORM2 gene loci 9q34.1-q34.3 in Egyptians. In this study, 271 plasma samples from unrelated healthy blood donors were collected Description and used within a few days of collection. ORM2 gene encodes one of the two forms of Isoelectric focusing was used for phenotyping all plasma protein called orosomucoid (ORM). The samples. Also, Sebetan et al. (1997) studied the plasma ORM proteins is made of a mixture of ORM2 locus in the Qatari and Sudanese ORM2 and ORM1 proteins in a molar ratio of 1:3, populations. In the three populations, the ORM2 respectively. ORM protein is a member of the locus showed one common and nine variants lipocalin family. ORM protein is relatively phenotypes that are determined by nine ORM2 abundant plasma protein where its concentration is alleles: ORM2*M, ORM2*L4, ORM2*H2, 2.5 mg/ml in healthy normal individuals. This ORM2*H10, ORM2*H13, ORM2*H14, concentration is known to rise dramatically in ORM2*Q0, a new allele designated ORM2*H21, response to acute infection, inflammation, surgery, and a double-banded allele that is renamed cancer, and other stimuli. This phenomenon, ORM2*HX. Family studies of the new allele known as the acute phase reaction, is common to all (ORM*H21) are in accordance with co-dominant mammals. The proteins participating in it are autosomal inheritance. Sebetan et al. (1997) found known as acute phase reactants and ORM protein is five ORM1 alleles in Egyptians which are in a major acute-phase reactive plasma protein. ORM decreasing order: ORM2*M, ORM2*H2, is also considered a binding protein for certain ORM2*H13, ORM2*H14, and ORM2*HX. The drugs in plasma. Additionally, it is an most common phenotype found in Egyptians is the immunomodulatory protein with the ability to down M phenotype of the ORM2 combined with the regulate complement activation, along with various ORM1 phenotypes. Out of the 271 subjects phagocytic functions and T-cell-mediated activities. analyzed, 119 had the M phenotype of the ORM2 combined with F1.S phenotype (determined by two

ORM1 (F1/S and dF1S/dF1S) genotypes) of the and used within a few days of collection. Sebetan ORM1. The M phenotype combined with the F1 et al. (1997) found four ORM2 alleles in Sudanese and S phenotypes of the ORM1 was found in 90 people that are in decreasing order: ORM2*M, and 35 Egyptians, respectively. ORM2*H2, ORM2*H21, and ORM2*HX. The most common phenotype found in Sudanese people Libya is the M phenotype of the ORM2 combined with Sebetan and Sagisaka (1988) characterized the the ORM1 phenotypes. Out of the 195 subjects genetic polymorphisms of orosomucoid ORM2 and analyzed, 82 had the M phenotype of the ORM2 ORM2 in Libyans and indicated the occurrence of combined with F1.S phenotype (determined by two three new ORM2 alleles. No further details could ORM1 (F1/S and dF1S/dF1S) genotypes) of the be obtained on this subject. ORM1. The M phenotype combined with the F1 and S phenotypes of the ORM1 was found in 55 Qatar and 72 Sudanese, respectively [See also: Egypt > Sebetan et al. (1997) carried out a study to Sebetan et al., 1997]. investigate the genetic variants of the human plasma orosomucoid ORM1 and ORM2 gene loci References in Qataris. In this study, 400 plasma samples from Sebetan IM, Oshida S, Yuasa I, Tie J. Genetic unrelated healthy blood donors were collected and polymorphisms of orosomucoid ORM1 and used within a few days of collection. Sebetan et al. ORM2 in Egyptians, Sudanese, and Qataris: (1997) found four ORM2 alleles in Qataris which occurrence of two new alleles. Hum Biol. 1997; are in decreasing order: ORM2*M, ORM2*L4, 69(1):121-9. PMID: 9037900 ORM2*H10, and ORM2*H21. The most common Sebetan IM, Sagisaka K. Genetic polymorphisms of phenotype in Qataris is the M phenotype of the orosomucoid ORM1 and ORM2 in Libyans: ORM2 combined with the ORM1 phenotypes. Out occurrence of ORM1*2.1 and three new ORM2 of the 400 subjects analyzed, 177 had the M alleles. Jinrui Idengaku Zasshi. 1988; 33(4):439- phenotype of the ORM2 combined with F1.S 43. PMID: 3251077 phenotype (determined by two ORM1 (F1/S and dF1S/dF1S) genotypes) of the ORM1. The M Related CTGA Records phenotype combined with the F1 and S phenotypes Orosomucoid 1 of the ORM1 was found in 193 and 59 Qataris, respectively [See also: Egypt > Sebetan et al., External Links 1997]. http://www.genecards.org/cgi- bin/carddisp.pl?gene=ORM2 Sudan Sebetan et al. (1997) carried out a study to Contributors investigate the genetic variants of the human Pratibha Nair: 10.5.2011 plasma orosomucoid ORM1 and ORM2 gene loci Ghazi O. Tadmouri: 5.5.2009 in Sudanese. In this study, 195 plasma samples Tasneem Obeid: 29.6.2008 from unrelated healthy blood donors were collected