DOCSLIB.ORG

Flavonoids from Duckweeds

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Flavonoids from Duckweeds RSC Advances PAPER View Article Online View Journal | View Issue Flavonoids from duckweeds: potential applications in the human diet† Cite this: RSC Adv., 2020, 10, 44981 a ab a Debora´ Pagliuso, Carmen Eusebia Palacios Jara, Adriana Grandis, c b a Eric Lam, Marcelo Jose´ Pena Ferreira and Marcos Silveira Buckeridge * Duckweeds are the smallest free-floating flowering aquatic plants. Their biotechnological applications include their use as food, bioenergy, and environmental sustainability, as they can help clean polluted water. The high growth capacity and their chemical properties make them suitable for human health applications. Here we evaluated the ethanolic extracts from five species of duckweeds by HPLC-DAD/ MS-MS for chemical characterization. Sixteen compounds were identified and quantified, in which three were chlorogenic acid derivatives and eleven apigenin and luteolin derivatives. We describe for the first time the presence in duckweeds of 5-O-(E)-caffeoylquinic acid (1), 3-O-(E)-coumaroylquinic acid (2), luteolin-7-O-glucoside-C-glucoside (3), 4-O-(E)-coumaroylquinic acid (4), luteolin-6-C-glucoside-8-C- rhamnoside (5), and luteolin-8-C-glucoside-6-C-rhamnoside (6). The flavonoids diversity showed Creative Commons Attribution-NonCommercial 3.0 Unported Licence. a significant content of luteolin and its derivatives, except for Landoltia punctata that had significant Received 4th August 2020 apigenin content. Flavones identified in duckweeds were mostly C-glycosides, which can benefit human Accepted 21st November 2020 diets, and its abundance seems to be related to the higher antioxidant and anticancer capacities of DOI: 10.1039/d0ra06741e Wolffiella caudata, Wolffia borealis, and Landoltia punctata. Our findings reinforce the idea that rsc.li/rsc-advances duckweeds could be valuable additives to the human diet, and their potential should be further explored. Introduction Among the secondary metabolites, the avonoids are a group of compounds synthesized from cinnamic acid derivatives This article is licensed under a Duckweed is the given name for the smallest owering aquatic coupled with three acetate units that display several biological 15 plants that belong to Lemnaceae, which comprises 36 species roles. These polyphenol compounds are characterized by the grouped in ve genera: Landoltia, Lemna, Spirodela, Wolffia, and C15 skeleton arranged in two phenyl rings and a heterocyclic 1,2 – – Open Access Article. Published on 21 December 2020. Downloaded 10/2/2021 7:59:21 AM. Wolffiella. Furthermore, these plants are subdivided into the ring (C6 C3 C6). The substitution pattern of the central ring subfamilies Lemnoideae and Wolffioideae, which contain along with the degree of unsaturation and the oxidation of the respectively the species of Landoltia, Lemna and Spirodela, and avonoid structure resolve this group of compounds into six the rootless species of Wolffia and Wolffiella.3 These plants are main classes: avonol, avone, avanonol, avanone, antho- 14,16,17 capable of duplicating their biomass in 96 hours, conferring cyanin, and isoavonoid. Despite their grossly similar enormous applicability in biotechnology as water remediators, chemical properties, the avonoids in plants are involved in for environmental monitoring, food, biofuels, and cosmetic diverse processes such as growth, photosynthesis, and protective production as well as pharmaceutical intakes.4–10 The evolution biological systems such as seed development, pollination, light trend in Lemnaceae has a relationship with secondary metab- screening, defence against pathogens, protection against UV- olites and cell wall composition despite its diversity.11,12 damage, temperature acclimation, and drought resistance. Also, In plants, the secondary metabolites consist of a broad group some avonoids can act as signaling molecules for allelopathic 13,14 of compounds produced to benet the organism for different interactions, such as phytoalexins and detoxifying agents. purposes: those related to the internal functioning of the plant Besides the natural bioactive properties in plants, avonoids and others selected by their applications for human health.13,14 are phytochemicals with several medically-relevant biological activities such as antiviral, antifungal, antibacterial anti- hepatotoxic, anti-osteoporotic, antiulcer, anti-prolifera- a Laboratory of Plant Physiological Ecology, Department of Botany, Institute of 16,18–21 ˜ tive. Flavonoids display several other properties such as Biosciences, University of Sao Paulo, Brazil ff bLaboratory of Phytochemistry, Department of Botany, Institute of Biosciences, immunomodulation, apoptotic e ects, and consolidation of University of Sao˜ Paulo, Brazil applications on carcinogenesis, in ammation, atherosclerosis, 16,18,19 cDepartment of Plant Biology and Pathology, Rutgers, The State University of New and thrombosis. Flavonoids are also considered func- Jersey, New Brunswick, New Jersey, USA. E-mail: [email protected] tional foods that benet human health.16,18,19 Considering the † Electronic supplementary information (ESI) available. See DOI: applications for human food, the antioxidant capacity of 10.1039/d0ra06741e This journal is © The Royal Society of Chemistry 2020 RSC Adv.,2020,10,44981–44988 | 44981 View Article Online RSC Advances Paper avonoids has an essential action in preventing the formation (ThermoScientic® Savant SC 250 EXP), and resuspended in À of reactive oxygen and nitrogen species, causing damage in 2mgmL 1 in a hydroethanolic solution of 80% ethanol. DNA, proteins, lipids, and other biomolecules.22,23 Remarkable knowledge is found in the literature about the wine and tea phenolic compounds, which are responsible for their activity in the HPLC-DAD-ESI-MS/MS analysis of phenolic compounds in prevention of heart diseases and cancer.24–27 Thus, the intake of duckweeds polyphenols present in plants is desirable for human health. Samples diluted in ethanol 80% were ltered through a 0.45 mm Recently, avonoidssuchasquercetinandrutinhavebeenshown Nylon syringe, and reversed-phase HPLC-DAD analyzed the to interfere with the entrance of the SARS-Cov-2 in cells, high- extracts of duckweeds on an Agilent 1260. The phenolic 28 lighting their potential to treat the COVID-19 disease. compounds were separated using a Zorbax Eclipse Plus C18 Duckweeds can have high levels of avonoids and together column (4.6 Â 150 mm, 3.5 mm) maintained at 45 C. The with its nutritional value of amino acids and proteins make it injection volume of the sample was 5 mL. The solvents used in 29–34 suitable for human consumption with health bene ts. the mobile phase were 0.1% acetic acid in Milli-Q water (A) and Duckweeds have been sources of human food in several Asian acetonitrile (B), with the following concentration gradient of B: 35 countries. Moreover, one duckweed species (Spirodela polyrhiza) 0–3 min, 0%, 3–8 min, 0–10%, 8–8.1 min, 10–11%, 8.1–15 min, is being used to treat urticaria, acute nephritis, in uenza, and 11%, 15–15.1 min, 11–12%, 15.1–20 min, 12%, 20–20.1 min, 12– 36,37 in ammation in Japan, Korea, and China. Several studies 13%, 20.1–25 min, 13%, 25–30 min, 13–23%, 30–38 min, 23– identi ed avonoids mainly quercetin, apigenin, and luteolin 30%, 38–43 min, 30–50%, 43–65 min, 50–100 min, 65–70 min. 18,31,38 derivatives as compounds in Spirodela polyrhiza extracts and The phenolic acids and avonoids were detected at 325 nm and these components are probably related to the pharmacological 352 nm, respectively. Identication of compounds from duck- applications of this duckweed in traditional medicine. weeds was carried out through HPLC-DAD-MS/MS (Agilent 1260 Based on the importance of the duckweed family for phar- coupled to an Esquire 3000 Plus mass spectrometer) using the Creative Commons Attribution-NonCommercial 3.0 Unported Licence. macology and nutrition, this paper aimed at investigating the same chromatographic conditions and a negative ionization phenolic composition of ethanolic extracts and antioxidant mode. Quantication of each phenolic compound was carried out activity from ve species of duckweeds in order to characterize by comparing the peak areas obtained from HPLC analysis with À further the range of natural variations in the varieties of avo- calibration curves of standards at the range of 1.5–150 mgmL 1, noids produced by this plant family. according to the phenolic class. Chlorogenic acid, vitexin, and orientin were used to quantify phenolic acids, apigenin, and Experimental luteolin derivatives. Duckweed strains, cultivation method, and sample preparation This article is licensed under a Antioxidant activity Five-species of duckweeds were investigated in this study. Three The antioxidant activity was evaluated by the 1,1-diphenyl-2- Lemnoideae species (Landoltia punctata, Lemna gibba, and Spi- picryl-hydrazyl (DPPH) (Sigma-Aldrich®) method that is based rodela polyrhiza) and two Wolffioideae species (Wolffia borealis 39 Open Access Article. Published on 21 December 2020. Downloaded 10/2/2021 7:59:21 AM. upon the elimination of the free radical by the samples. For and Wolffiella caudata) were obtained from the Rutgers Duck- the assay, a 0.2 mM DPPHc solution in methanol was freshly weed Stock Cooperative (RDSC) collection. Landoltia punctata prepared, and 200 mL of DPPHc solution was reacted with 20 mL (7624), Lemna gibba (DWC128), Spirodela polyrhiza (9509), À of the plants' extracts (2 mg mL 1) diluted in 10, 20, 50, 100, and Wolffia borealis (9144) and Wolffiella caudata (9139) were culti- À1 À 200 mgmL . The reaction was incubated in the dark for 20 min, vated on Schenk–Hildebrandt medium (1.6 g L 1) supple- and the absorbance was measured at 515 nm with EPOCH mented with 0.5% of sucrose, pH 6.5 at 25 C with À equipment (Sellex Inc.). All samples were analyzed with three a photoperiod of 16 h of light in the intensity of 20 mmol m 2 À biological replicates and three technical replicates. The cali- s 1.Aer 21 days of cultivation, the plants were frozen in liquid bration curve was performed with a methanol Trolox (6-hydroxy- nitrogen, freeze-dried and pulverized by Geno/Grinder®2010 2,5,7,8-tetramethylchroman-2-carboxylic acid) (Sigma-Aldrich®) SPEX SamplePrep.
Load more

Recommended publications
  • Identification of Compounds That Rescue Otic and Myelination
    RESEARCH ARTICLE Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant Elvira Diamantopoulou1†, Sarah Baxendale1†, Antonio de la Vega de Leo´ n2, Anzar Asad1, Celia J Holdsworth1, Leila Abbas1, Valerie J Gillet2, Giselle R Wiggin3, Tanya T Whitfield1* 1Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom; 2Information School, University of Sheffield, Sheffield, United Kingdom; 3Sosei Heptares, Cambridge, United Kingdom Abstract Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in myelination of the peripheral nervous system. In the zebrafish, mutation of adgrg6 also results in defects in the inner ear: otic tissue fails to down-regulate versican gene expression and morphogenesis is disrupted. We have designed a whole-animal screen that tests for rescue of both up- and down-regulated gene expression in mutant embryos, together with analysis of weak and strong alleles. From a screen of 3120 structurally diverse compounds, we have identified 68 that reduce versican b expression in the adgrg6 mutant ear, 41 of which also restore myelin basic protein gene expression in Schwann cells of mutant embryos. Nineteen compounds unable to rescue a strong adgrg6 allele provide candidates for molecules that may interact directly with the Adgrg6 receptor. Our pipeline provides a powerful approach for identifying compounds that modulate GPCR activity, with potential impact for future drug design. DOI: https://doi.org/10.7554/eLife.44889.001 *For correspondence: [email protected] †These authors contributed Introduction equally to this work Adgrg6 (Gpr126) is an adhesion (B2) class G protein-coupled receptor (aGPCR) with conserved roles in myelination of the vertebrate peripheral nervous system (PNS) (reviewed in Langenhan et al., Competing interest: See 2016; Patra et al., 2014).
    [Show full text]
  • Phylogeny and Systematics of Lemnaceae, the Duckweed Family
    Systematic Botany (2002), 27(2): pp. 221±240 q Copyright 2002 by the American Society of Plant Taxonomists Phylogeny and Systematics of Lemnaceae, the Duckweed Family DONALD H. LES,1 DANIEL J. CRAWFORD,2,3 ELIAS LANDOLT,4 JOHN D. GABEL,1 and REBECCA T. K IMBALL2 1Department of Ecology and Evolutionary Biology, University of Connecticut, Storrs, Connecticut 06269-3043; 2Department of Evolution, Ecology, and Organismal Biology, The Ohio State University, Columbus, Ohio 43210; 3Present address: Department of Ecology and Evolutionary Biology, The University of Kansas, Lawrence, Kansas 66045-2106; 4Geobotanisches Institut ETH, ZuÈ richbergstrasse 38, CH-8044, ZuÈ rich, Switzerland Communicating Editor: Jeff H. Rettig ABSTRACT. The minute, reduced plants of family Lemnaceae have presented a formidable challenge to systematic inves- tigations. The simpli®ed morphology of duckweeds has made it particularly dif®cult to reconcile their interspeci®c relation- ships. A comprehensive phylogenetic analysis of all currently recognized species of Lemnaceae has been carried out using more than 4,700 characters that include data from morphology and anatomy, ¯avonoids, allozymes, and DNA sequences from chloroplast genes (rbcL, matK) and introns (trnK, rpl16). All data are reasonably congruent (I(MF) , 6%) and contributed to strong nodal support in combined analyses. Our combined data yield a single, well-resolved, maximum parsimony tree with 30/36 nodes (83%) supported by bootstrap values that exceed 90%. Subfamily Wolf®oideae is a monophyletic clade with 100% bootstrap support; however, subfamily Lemnoideae represents a paraphyletic grade comprising Landoltia, Lemna,and Spirodela. Combined data analysis con®rms the monophyly of Landoltia, Lemna, Spirodela, Wolf®a,andWolf®ella.
    [Show full text]
  • GRAS Notice (GRN) No. 719, Orange Pomace
    GRAS Notice (GRN) No. 719 https://www.fda.gov/Food/IngredientsPackagingLabeling/GRAS/NoticeInventory/default.htm SAFETY EVALUATION DOSSIER SUPPORTING A GENERALLY RECOGNIZED AS SAFE (GRAS) CONCLUSION FOR ORANGE POMACE SUBMITTED BY: PepsiCo, Inc. 700 Anderson Hill Road Purchase, NY 10577 SUBMITTED TO: U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Food Additive Safety HFS-200 5100 Paint Branch Parkway College Park, MD 20740-3835 CONTACT FOR TECHNICAL OR OTHER INFORMATION: Andrey Nikiforov, Ph.D. Toxicology Regulatory Services, Inc. 154 Hansen Road, Suite 201 Charlottesville, VA 22911 July 3, 2017 Table of Contents Part 1. SIGNED STATEMENTS AND CERTIFICATION ...........................................................1 A. Name and Address of Notifier .............................................................................................1 B. Name of GRAS Substance ...................................................................................................1 C. Intended Use and Consumer Exposure ................................................................................1 D. Basis for GRAS Conclusion ................................................................................................2 E. Availability of Information ..................................................................................................3 Part 2. IDENTITY, METHOD OF MANUFACTURE, SPECIFICATIONS, AND PHYSICAL OR TECHNICAL EFFECT.................................................................................................4
    [Show full text]
  • (Piper Nigrum L.) Products Based on LC-MS/MS Analysis
    molecules Article Nontargeted Metabolomics for Phenolic and Polyhydroxy Compounds Profile of Pepper (Piper nigrum L.) Products Based on LC-MS/MS Analysis Fenglin Gu 1,2,3,*, Guiping Wu 1,2,3, Yiming Fang 1,2,3 and Hongying Zhu 1,2,3,* 1 Spice and Beverage Research Institute, Chinese Academy of Tropical Agricultural Sciences, Wanning 571533, China; [email protected] (G.W.); [email protected] (Y.F.) 2 National Center of Important Tropical Crops Engineering and Technology Research, Wanning 571533, China 3 Key Laboratory of Genetic Resources Utilization of Spice and Beverage Crops, Ministry of Agriculture, Wanning 571533, China * Correspondence: [email protected] (F.G.); [email protected] (H.Z.); Tel.: +86-898-6255-3687 (F.G.); +86-898-6255-6090 (H.Z.); Fax: +86-898-6256-1083 (F.G. & H.Z.) Received: 16 July 2018; Accepted: 7 August 2018; Published: 9 August 2018 Abstract: In the present study, nontargeted metabolomics was used to screen the phenolic and polyhydroxy compounds in pepper products. A total of 186 phenolic and polyhydroxy compounds, including anthocyanins, proanthocyanidins, catechin derivatives, flavanones, flavones, flavonols, isoflavones and 3-O-p-coumaroyl quinic acid O-hexoside, quinic acid (polyhydroxy compounds), etc. For the selected 50 types of phenolic compound, except malvidin 3,5-diglucoside (malvin), 0 L-epicatechin and 4 -hydroxy-5,7-dimethoxyflavanone, other compound contents were present in high contents in freeze-dried pepper berries, and pinocembrin was relatively abundant in two kinds of pepper products. The score plots of principal component analysis indicated that the pepper samples can be classified into four groups on the basis of the type pepper processing.
    [Show full text]
  • Revisiting Greek Propolis: Chromatographic Analysis and Antioxidant Activity Study
    RESEARCH ARTICLE Revisiting Greek Propolis: Chromatographic Analysis and Antioxidant Activity Study Konstantinos M. Kasiotis1*, Pelagia Anastasiadou1, Antonis Papadopoulos2, Kyriaki Machera1* 1 Benaki Phytopathological Institute, Department of Pesticides Control and Phytopharmacy, Laboratory of Pesticides' Toxicology, Kifissia, Athens, Greece, 2 Benaki Phytopathological Institute, Department of Phytopathology, Laboratory of Non-Parasitic Diseases, Kifissia, Athens, Greece * [email protected] (KMK); [email protected] (KM) Abstract a1111111111 Propolis is a bee product that has been extensively used in alternative medicine and recently a1111111111 a1111111111 has gained interest on a global scale as an essential ingredient of healthy foods and cosmet- a1111111111 ics. Propolis is also considered to improve human health and to prevent diseases such as a1111111111 inflammation, heart disease, diabetes and even cancer. However, the claimed effects are anticipated to be correlated to its chemical composition. Since propolis is a natural product, its composition is consequently expected to be variable depending on the local flora align- ment. In this work, we present the development of a novel HPLC-PDA-ESI/MS targeted OPEN ACCESS method, used to identify and quantify 59 phenolic compounds in Greek propolis hydroalco- holic extracts. Amongst them, nine phenolic compounds are herein reported for the first time Citation: Kasiotis KM, Anastasiadou P, Papadopoulos A, Machera K (2017) Revisiting in Greek propolis. Alongside GC-MS complementary analysis was employed, unveiling Greek Propolis: Chromatographic Analysis and eight additional newly reported compounds. The antioxidant activity study of the propolis Antioxidant Activity Study. PLoS ONE 12(1): samples verified the potential of these extracts to effectively scavenge radicals, with the e0170077. doi:10.1371/journal.pone.0170077 extract of Imathia region exhibiting comparable antioxidant activity to that of quercetin.
    [Show full text]
  • Apigenin 520-36-5
    SUMMARY OF DATA FOR CHEMICAL SELECTION Apigenin 520-36-5 BASIS OF NOMINATION TO THE CSWG Apigenin is brought to the attention of the CSWG because of a recent scientific article citing this flavonoid as a substance that can be metabolically activated to produce toxic prooxidant phenoxyl radicals. Pure apigenin is used primarily in research as a protein kinase inhibitor that may suppress tumor promotion and that has anti-proliferating effects on human breast cancer cells and inhibitory actions on MAP kinase. Apigenin is also one of several active ingredients in the popular herbal remedy, chamomile. Apigenin is found naturally in many fruits and vegetables, including apples and celery. It is found in several popular spices, including basil, oregano, tarragon, cilantro, and parsley. As a representative of flavonoids containing phenol B rings that may induce lipid peroxidation, apigenin is a candidate for testing. SELECTION STATUS ACTION BY CSWG: 12/12/00 Studies requested: Developmental toxicity Short-term tests for chromosomal aberrations Priority: None assigned Rationale/Remarks: Nomination based on concerns about apigenin’s potential to produce possibly toxic radicals and its estrogenic activity NCI will conduct a mouse lymphoma assay Apigenin 520-36-5 CHEMICAL IDENTIFICATION CAS Registry Number: 520-36-5 Chemical Abstracts Service Name: 4H-1-benzopyran-4-one,5,7-dihydroxy-2-(4- hydroxy-phenyl)- (9CI) Synonyms and Trade Names: Apigenin; apigenine; apigenol; chamomile; C.I. natural yellow 1; 2-(p-hydroxyphenyl)-5,7- dihydroxy-chromone; spigenin; 4',5,7- trihydroxyflavone Structural Class: Flavone Structure, Molecular Formula and Molecular Weight: OH HO O OH O C15H10O5 Mol.
    [Show full text]
  • Phenolic Compounds and Uses in Fruit Growing A,B Melekber SULUSOGLU * Akocaeli University, Arslanbey Agricultural Vocational School, TR-41285, Kocaeli/Turkey
    Turkish Journal of Agricultural and Natural Sciences Special Issue: 1, 2014 TÜRK TURKISH TARIM ve DOĞA JOURNAL of AGRICULTURAL BİLİMLERİ DERGİSİ and NATURAL SCIENCES www.turkjans.com Phenolic Compounds and Uses in Fruit Growing a,b Melekber SULUSOGLU * aKocaeli University, Arslanbey Agricultural Vocational School, TR-41285, Kocaeli/Turkey. bKocaeli University, Graduate School of Natural and Applied Sciences, Department of Horticulture, TR-41380, Kocaeli/Turkey *Corresponding author: [email protected] Abstract Phenolic compounds are a class of chemical compounds in organic chemistry which consist of a hydroxyl group directly bonded to an aromatic hydrocarbon group. Phenolic compounds find in cell wall structures and play a major role in the growth regulation of plant as an internal physiological regulators or chemical messengers. They are used in the fruit growing field. They are related with defending system against pathogens and stress. They increase the success of tissue culture; can be helpful to identification of fruit cultivars, to determination of graft compatibility and identification of vigor of trees. They are also important because of their contribution to the sensory quality of fruits during the technological processes. In this review, the simple classification was given for these compounds and uses in the agricultural field were described. Key words: Phenolic compounds, fruit quality, fruit growing, cultivar identification, grafting, tree vigor Fenolik Bileşikler ve Meyve Yetiştiriciliğinde Kullanımı Özet Aromatik hidrokarbon grubuna bağlı bir hidroksil grubu içeren fenolik bileşikler organik kimyanın bir sınıfıdır. Fenolik bileşikler hücre duvarı yapısında bulunmakta ve içsel bir fizyolojik düzenleyici veya kimyasal haberci olarak bitki büyümesinin organizasyonunda önemli rol oynamaktadır. Meyve yetiştiriciliği alanında kullanılmaktadır.
    [Show full text]
  • 48003 Hughes Et Al 2017 Accepted Version.Pdf
    ResearchOnline@JCU This is the Accepted Version of a paper published in the Journal: Critical Reviews in Food Science and Nutrition Hughes, Samuel D., Ketheesan, Natkunam, and Haleagrahara, Nagaraja (2017) The therapeutic potential of plant flavonoids on rheumatoid arthritis. Critical Reviews in Food Science and Nutrition, 57 (17). pp. 3601-3613. http://dx.doi.org/10.1080/10408398.2016.1246413 © 2015. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ Critical Reviews in Food Science and Nutrition ISSN: 1040-8398 (Print) 1549-7852 (Online) Journal homepage: http://www.tandfonline.com/loi/bfsn20 The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis Samuel D. Hughes, Natkunam Ketheesan & Nagaraja Haleagrahara To cite this article: Samuel D. Hughes, Natkunam Ketheesan & Nagaraja Haleagrahara (2016): The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis, Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2016.1246413 To link to this article: http://dx.doi.org/10.1080/10408398.2016.1246413 Accepted author version posted online: 22 Nov 2016. Submit your article to this journal Article views: 122 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at http://www.tandfonline.com/action/journalInformation?journalCode=bfsn20 Download by: [JAMES COOK UNIVERSITY] Date: 23 March 2017, At: 16:37 ACCEPTED MANUSCRIPT The Therapeutic Potential of Plant Flavonoids on Rheumatoid Arthritis Samuel D. Hughes1, Natkunam Ketheesan2 & Nagaraja Haleagrahara3,* 1,2,3Biomedicine, College of Public Health, Medical & Veterinary Sciences, and 2, 3Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Townsville, Australia *Address correspondence to: Nagaraja Haleagrahara, Biomedicine, College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Australia.
    [Show full text]
  • EP1776161B1.Pdf
    (19) TZZ____T (11) EP 1 776 161 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention (51) Int Cl.: of the grant of the patent: A61Q 5/02 (2006.01) A61Q 7/00 (2006.01) 26.10.2016 Bulletin 2016/43 A61Q 19/00 (2006.01) A61K 8/36 (2006.01) A61K 8/362 (2006.01) A61K 8/37 (2006.01) (2006.01) (2006.01) (21) Application number: 05718804.7 A61K 8/39 A61Q 1/02 A61Q 5/06 (2006.01) A61K 8/64 (2006.01) A61Q 5/12 (2006.01) A61Q 11/00 (2006.01) (22) Date of filing: 25.04.2005 A61K 8/81 (2006.01) A61Q 19/06 (2006.01) A61Q 19/08 (2006.01) A61K 8/97 (2006.01) A61K 8/42 (2006.01) A61K 8/49 (2006.01) A61Q 5/00 (2006.01) A61K 8/73 (2006.01) (86) International application number: PCT/IB2005/051344 (87) International publication number: WO 2005/102266 (03.11.2005 Gazette 2005/44) (54) COSMETIC OR DERMOPHARMACEUTICAL COMPOSITION COMPRISING AT LEAST ONE UDP GLUCURONOSYL TRANSFERASE (UGT) ENZYMES INDUCER KOSMETISCHE ODER DERMOPHARMAZEUTISCHE ZUSAMMENSETZUNG MIT MINDESTENS EINEM UDP-GLUCURONOSYL-TRANSFERASE (UGT) ENZYM-INDUKTOR COMPOSITION COSMETIQUE OU DERMOPHARMACEUTIQUE COMPRENANT AU MOINS UN INDUCTEUR D’ENZYMES UDP-GLUCURONOSYLTRANSFERASES (UGT) (84) Designated Contracting States: • PATENT ABSTRACTS OF JAPAN vol. 2000, no. DE ES FR GB IT 14, 5 March 2001 (2001-03-05) & JP 2000 319154 A(NIPPON MENAADEKESHOHIN KK; ICHIMARU (30) Priority: 26.04.2004 FR 0404408 PHARCOS CO LTD), 21 November 2000 (2000-11-21) (43) Date of publication of application: • DATABASE WPI Derwent Publications Ltd., 25.04.2007 Bulletin 2007/17 London, GB; AN 2001-481491 XP002309671 CHEOUNG J H ET AL.: "Chrysin 7-o-crotonate, its (73) Proprietor: Sederma S.A.S.
    [Show full text]
  • Identification of Compounds That Rescue Otic And
    bioRxiv preprint doi: https://doi.org/10.1101/520056; this version posted January 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 1 Identification of compounds that rescue otic and myelination defects in the 2 zebrafish adgrg6 (gpr126) mutant 3 4 Elvira Diamantopoulou1,*, Sarah Baxendale1,*, Antonio de la Vega de León2, Anzar Asad1, 5 Celia J. Holdsworth1, Leila Abbas1, Valerie J. Gillet2, Giselle R. Wiggin3 and Tanya T. 6 Whitfield1# 7 8 1Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield, 9 S10 2TN, UK 10 2Information School, University of Sheffield, Sheffield, S1 4DP, UK 11 3Sosei Heptares, Steinmetz Building, Granta Park, Cambridge, CB21 6DG, UK 12 13 *These authors contributed equally 14 15 #Corresponding author: 16 Tanya T. Whitfield: [email protected] 17 ORCID iD: 0000-0003-1575-1504 18 19 Key words: zebrafish, aGPCR, Adgrg6, Gpr126, phenotypic screening, chemoinformatics, 20 versican, myelination, inner ear, lateral line, Schwann cells 21 22 1 bioRxiv preprint doi: https://doi.org/10.1101/520056; this version posted January 16, 2019. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY 4.0 International license. 23 ABSTRACT 24 Adgrg6 (Gpr126) is an adhesion class G protein-coupled receptor with a conserved role in 25 myelination of the peripheral nervous system.
    [Show full text]
  • Lemna Minor: Traditional Uses, Chemical Constituents and Pharmacological Effects- a Review
    IOSR Journal Of Pharmacy www.iosrphr.org (e)-ISSN: 2250-3013, (p)-ISSN: 2319-4219 Volume 9, Issue 8 Series. I (August 2019), PP. 06-11 Lemna minor: Traditional Uses, Chemical Constituents and Pharmacological Effects- A Review Ali Esmail Al-Snafi Department of Pharmacology, College of Medicine, Thi qar University, Iraq. Corresponding Author: Ali Esmail Al-Snafi Abstract: Lemna minor was used traditionally as antipruritic, antiscorbutic, astringent, depurative, diuretic, febrifuge and soporific. It was also used in the treatment of colds, measles, oedema and difficulty in urination. It contained carbohydrates, proteins, lipids, flavonoid, trace elements and many other contents. The pharmacological studies revealed that it possessed antimicrobial, antioxidant, cytotoxic and immunomodulatory effects. The current review discussed the traditional uses, chemical constituents and pharmacological effects of Lemna minor. Keywords: traditional uses, constituents, pharmacological effects, Lemna minor ----------------------------------------------------------------------------------------------------------------------------- ---------- Date of Submission: 26-07-2019 Date of Acceptance: 12-08-2019 ----------------------------------------------------------------------------------------------------------------------------- ---------- I. INTRODUCTION Recent reviews showed that plants produce many secondary metabolites which are bio-synthetically derived from primary metabolites and constitute an important source of many drugs. Recent reviews revealed that
    [Show full text]
  • Mississippi Flora. I. Monocotyledon Families with Aquatic Or Wetland Species
    Gulf and Caribbean Research Volume 4 Issue 3 January 1974 Mississippi Flora. I. Monocotyledon Families with Aquatic or Wetland Species Samuel B. Jones Jr. University of Georgia Follow this and additional works at: https://aquila.usm.edu/gcr Part of the Botany Commons, and the Marine Biology Commons Recommended Citation Jones, S. B. Jr. 1974. Mississippi Flora. I. Monocotyledon Families with Aquatic or Wetland Species. Gulf Research Reports 4 (3): 357-379. Retrieved from https://aquila.usm.edu/gcr/vol4/iss3/4 DOI: https://doi.org/10.18785/grr.0403.04 This Article is brought to you for free and open access by The Aquila Digital Community. It has been accepted for inclusion in Gulf and Caribbean Research by an authorized editor of The Aquila Digital Community. For more information, please contact [email protected]. MlSSISSlPPl FLORA. I. MONOCOTYLEDON FAMILIES WITH AQUATIC OR WETLAND SPECIES: bY SAMUEL B. JONES, JR. Department of Botany The University of Georgia Athens, Georgia ABSTRACT Keys, distribution maps, habitats, references, nomenclature, and notes are given for some 16 families of monocotyledons occurring naturally or naturalized in Mississippi. These families all contain one or more species which are found in aquatic or wetland habitats. They are: Alismataceae, Araceae, Cannaceae, Haemodoraceae, Hydrocharitaceae, Juncaginaceae, Lemnaceae, Marantaceae, Mayacaceae, Najadaceae, Pontederiaceae, Potamogetonaceae, Rug piaceae, Sparganiaceae, Typhaceae, Zannichelliaceae. INTRODUCTION The primary aim of this paper is to improve our knowledge of the aquatic and wetland plants of Mississippi. In studying a number of families for the Mississippi Flora project, I became aware of the limited collections available for study of many aquatic and wetland species.
    [Show full text]