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TOX-84: Toxicity Studies of O-Phthalaldehyde (CASRN 643-79

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TOX-84: Toxicity Studies of O-Phthalaldehyde (CASRN 643-79 NTP TECHNICAL REPORT ON THE OXICITY TUDIES OF T S O-PHTHALALDEHYDE (CASRN 643-79-8) ADMINISTERED BY INHALATION TO SPRAGUE DAWLEY (HSD:SPRAGUE DAWLEY® SD®) RATS AND B6C3F1/N MICE NTP TOX 84 JANUARY 2018 NTP Technical Report on the Toxicity Studies of o-Phthalaldehyde (CASRN 643-79-8) Administered by Inhalation to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats and B6C3F1/N Mice Toxicity Report 84 January 2018 National Toxicology Program Public Health Service U.S. Department of Health and Human Services ISSN: 2378-8992 Research Triangle Park, North Carolina, USA o-Phthalaldehyde, NTP TOX 84 Foreword The National Toxicology Program (NTP) is an interagency program within the Public Health Service (PHS) of the Department of Health and Human Services (HHS) and is headquartered at the National Institute of Environmental Health Sciences of the National Institutes of Health (NIEHS/NIH). Three agencies contribute resources to the program: NIEHS/NIH, the National Institute for Occupational Safety and Health of the Centers for Disease Control and Prevention (NIOSH/CDC), and the National Center for Toxicological Research of the Food and Drug Administration (NCTR/FDA). Established in 1978, NTP is charged with coordinating toxicological testing activities, strengthening the science base in toxicology, developing and validating improved testing methods, and providing information about potentially toxic substances to health regulatory and research agencies, scientific and medical communities, and the public. The Toxicity Study Report series began in 1991. The studies described in the Toxicity Study Report series are designed and conducted to characterize and evaluate the toxicologic potential of selected substances in laboratory animals (usually two species, rats and mice). Substances selected for NTP toxicity studies are chosen primarily on the basis of human exposure, level of production, and chemical structure. The interpretive conclusions presented in the Toxicity Study Reports are based only on the results of these NTP studies. Extrapolation of these results to other species, including characterization of hazards and risks to humans, requires analyses beyond the intent of these reports. Selection per se is not an indicator of a substance’s toxic potential. NTP conducts its studies in compliance with its laboratory health and safety guidelines and FDA Good Laboratory Practice Regulations and must meet or exceed all applicable federal, state, and local health and safety regulations. Animal care and use are in accordance with the Public Health Service Policy on Humane Care and Use of Animals. Studies are subjected to retrospective quality assurance audits before being presented for public review. NTP Technical Reports are indexed in the National Center for Biotechnology Information (NCBI) Bookshelf and are available free of charge electronically on the NTP website (http://ntp.niehs.nih.gov). Additional information regarding this study may be requested through Central Data Management (CDM) at [email protected]. Toxicity data are available through NTP’s Chemical Effects in Biological Systems (CEBS) database: https://www.niehs.nih.gov/research/resources/databases/cebs/index.cfm. ii o-Phthalaldehyde, NTP TOX 84 Table of Contents Foreword ......................................................................................................................................... ii Tables ............................................................................................................................................. iv Figures..............................................................................................................................................v About This Report.......................................................................................................................... vi Peer Review ................................................................................................................................... ix Publication Details ...........................................................................................................................x Abstract .......................................................................................................................................... xi Introduction ......................................................................................................................................1 Chemical and Physical Properties ...............................................................................................1 Production, Use, and Human Exposure ......................................................................................1 Regulatory Status ........................................................................................................................2 Absorption, Distribution, Metabolism, and Excretion ................................................................3 Experimental Animals .........................................................................................................3 Humans ................................................................................................................................3 Toxicity .......................................................................................................................................3 Experimental Animals .........................................................................................................3 Humans ................................................................................................................................4 Reproductive and Developmental Toxicity ................................................................................5 Carcinogenicity ...........................................................................................................................5 Genetic Toxicity ..........................................................................................................................5 Study Rationale and Design ........................................................................................................5 Materials and Methods .....................................................................................................................6 Procurement and Characterization of o-Phthalaldehyde .............................................................6 Vapor Generation and Exposure System ....................................................................................7 Vapor Concentration Monitoring ................................................................................................7 Chamber Atmosphere Characterization ......................................................................................8 Animal Source .............................................................................................................................8 Animal Welfare ...........................................................................................................................9 Three-month Studies ...................................................................................................................9 Statistical Methods ....................................................................................................................15 Calculation and Analysis of Lesion Incidences .................................................................15 Analysis of Continuous Variables .....................................................................................15 Quality Assurance Methods ......................................................................................................15 Genetic Toxicology ...................................................................................................................15 Bacterial Mutagenicity Test Protocol ................................................................................15 Rat and Mouse Peripheral Blood Micronucleus Test Protocol ..........................................16 Evaluation Protocol ............................................................................................................16 Results ............................................................................................................................................18 Rats ............................................................................................................................................18 Mice...........................................................................................................................................40 iii o-Phthalaldehyde, NTP TOX 84 Genetic Toxicology ...................................................................................................................53 Discussion ......................................................................................................................................59 References ......................................................................................................................................64 Appendix A. Summary of Nonneoplastic Lesions in Rats and Mice ......................................... A-1 Appendix B. Clinical Pathology Results .....................................................................................B-1 Appendix C. Organ Weights and Organ Weight-to-Body-Weight Ratios ..................................C-1 Appendix D. Reproductive Tissue Evaluations .......................................................................... D-1
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