pharmacy Systematic Review Systematic Review of L-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women Nicole E. Cieri-Hutcherson 1,* , Andrea Jaenecke 2, Ajeet Bahia 2, Debra Lucas 3, Ann Oluloro 4, Lora Stimmel 2 and Timothy C. Hutcherson 5 1 Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA 2 School of Pharmacy, D’Youville College, Buffalo, NY 14201, USA;
[email protected] (A.J.);
[email protected] (A.B.);
[email protected] (L.S.) 3 Montante Family Library, D’Youville College, Buffalo, NY 14201, USA;
[email protected] 4 Department of Obstetrics and Gynecology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA;
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[email protected]; Tel.: +1-716-645-3635 Abstract: This systematic review evaluates the efficacy and safety of L-arginine alone or in combina- tion for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords “arginine”, “Lady Prelox”, “ArginMax”, “Stronvivo”, “Ristela”, “hypoactive sexual desire disorder”, “female sexual interest arousal disor- Citation: Cieri-Hutcherson, N.E.; der”, “female sexual arousal disorder”, “sexual dysfunction”, “sexual behavior”, “dyspareunia”, Jaenecke, A.; Bahia, A.; Lucas, D.; “libido”, and permutations thereof. Relevant records were retained if they were primary literature, Oluloro, A.; Stimmel, L.; Hutcherson, conducted in women with HSDD or related conditions, and published as full text in English.