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Table 1*. Brain Regions That Are Equally Activated by Both the YOUNG and OLD Groups During ISODIR and NONISODIR Coordination

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Table 1*. Brain Regions That Are Equally Activated by Both the YOUNG and OLD Groups During ISODIR and NONISODIR Coordination Table 1*. Brain regions that are equally activated by both the YOUNG and OLD groups during ISODIR and NONISODIR coordination Area activated Side x y z t value ISODIR coordination Superior frontal gyrus (SMA) M/L -8 -12 62 6.90 M/R 0 -12 66 6.78 Precentral gyrus / Central sulcus L -32 -30 64 13.04 (SM1 hand area) Postcentral gyrus L -14 -40 74 10.33 Paracentral lobule L -6 -38 68 10.25 Cingulate cortex (CMA) M/L -6 -28 48 7.06 Lateral sulcus / Posterior insula (S2) L -32 -28 16 6.69 R 56 -34 18 5.64 Thalamus L -24 -22 4 7.12 Putamen L -26 2 6 6.05 Pallidum L -26 -6 4 6.07 Cerebellar hemisphere (V) R 16 -56 -22 10.57 NONISODIR coordination Superior frontal gryrus (SMA) M/L -8 -12 60 7.07 Central sulcus / Precentral gyrus L -36 -30 62 12.40 Postcentral gyrus L -26 -40 72 10.53 Paracentral lobule L -6 -38 68 10.15 Cingulate cortex (CMA) M/L -8 -28 50 6.59 Lateral sulcus / Posterior insula (S2) L -32 -28 14 5.48 R 58 -32 20 6.26 Thalamus L -22 -20 4 6.15 Pallidum L -28 -4 2 6.55 Cerebellum (V) R 16 -56 -22 9.53 t values and localizations (MNI coordinates) of activation peaks of regions that were significantly (p < 0.05; FDR corrected for multiple comparisons) activated by both age groups during the ISODIR and NONISODIR coordination modes, respectively, resulting from the following conjunction analyses: (ISODIR-Rest)old ∩ (ISODIR-Rest)young and (NONISODIR-Rest)old ∩ (NONISODIR-Rest)young. L, Left hemisphere; R, right hemisphere; M, medial. Table 2*. Brain regions additionally activated by the old as compared to the young group during ISODIR and NONISODIR coordination Area activated Side x y z t value ISODIR coordination Anterior Insula L -36 24 -8 6.17 NONISODIR coordination Middle frontal gyrus (DLPFC) L -34 42 30 4.83 Inferior frontal gyrus pars triangularis L -42 28 26 5.43 pars opercularis -52 14 16 5.67 Anterior insula L -36 24 -8 5.56 Superior frontal sulcus/gyrus (pre-PMd) L -36 0 58 5.05 Superior temporal gyrus L -56 -16 0 5.93 Inferior postcentral sulcus (S2) L -56 -14 28 5.36 Parahippocampal gyrus R 26 -38 -10 4.84 Paracentral lobule M/R 8 -40 70 5.32 Fusiform gyrus L -40 -48 -14 4.87 Angular gyrus L -44 -52 42 4.55 Superior parietal gyrus L -26 -62 52 4.88 Lingual gyrus L -22 -74 -8 4.62 R 6 -80 -6 5.27 Cerebellar hemisphere (V) L -14 -54 -18 5.96 Cerebellar hemisphere (VI) L -30 -64 -16 5.47 R 32 -70 -20 5.53 Cerebellar hemisphere (VIIIB / IX) R 16 -56 -48 5.52 Cerebellar vermis (VIIB) L -6 -70 -32 4.66 t values and localizations (MNI coordinates) of activation peaks showing significantly (p < 0.05; FDR corrected for multiple comparisons) larger activation in the old group compared with the young group, during the ISODIR and NONISODIR coordination modes, respectively, resulting from the following contrasts: (ISODIR-Rest)old vs. (ISODIR-Rest)young and (NONISODIR-Rest)old vs. (NONISODIR- Rest)young. L, Left hemisphere; R, right hemisphere; M, medial. Table 3*. Brain regions that are equally activated in both age groups and in which performance and brain activation is positively correlated in the OLD group during NONISODIR coordination (without outlier) Region activated Side x y z t value Superior frontal gyrus (SMA) M/R 10 -14 58 2.84 Cingulate cortex (CMA) M/L -2 -26 46 3.20 Inferior central sulcus L -50 -16 44 3.58 Superior postcentral gyrus L -18 -48 72 4.16 t values and localizations (MNI coordinates) of activation peaks of regions that were significantly (p < 0.05; clusterwise FDR correction for multiple comparisons) activated by both age groups during the ISODIR and NONISODIR coordination modes, respectively, resulting from the following conjunction analyses: (ISODIR-Rest)old ∩ (ISODIR-Rest)young and (NONISODIR-Rest)old ∩ (NONISODIR- Rest)young. L, Left hemisphere; R, right hemisphere; M, medial; SMA, supplementary motor area; CMA, cingulate motor area. Table 4*. Brain regions additionally activated in the elderly as compared to the young subjects in which performance and brain activation is positively correlated in the OLD group during NONISODIR coordination (without outlier) Region activated Side x y z t value Middle frontal gyrus (DLPFC) L -32 38 30 3.00 Inferior frontal gyrus (pars L -42 18 18 3.33 opercularis/triangularis) Anterior insula L -50 18 -12 2.65 Superior frontal sulcus/gyrus (pre-PMd) L -36 2 52 3.14 Superior temporal gyrus L -56 -20 -2 2.20 Inferior postcentral sulcus (S2) L -58 -12 24 3.08 Superior parietal gyrus L -22 -62 56 3.32 Cerebellar hemisphere (V / VI) L -28 -48 -26 4.23 Cerebellar hemisphere (VI) R 34 -72 -24 2.25 t values and localizations (MNI coordinates) of activation peaks showing significantly (p < 0.05; clusterwise FDR correction for multiple comparisons) larger activation in the old group compared with the young group, during the ISODIR and NONISODIR coordination modes, respectively, resulting from the following contrasts: (ISODIR-Rest)old vs. (ISODIR-Rest)young and (NONISODIR-Rest)old vs. (NONISODIR-Rest)young. L, Left hemisphere; R, right hemisphere; M, medial; DLPFC, dorsolateral pre- frontal cortex; pre-PMd, pre-dorsal premotor cortex, S2, secondary somatosensory area). .
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