Toxicological Profile for Uranium
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Nuclear Energy in Everyday Life Nuclear Energy in Everyday Life
Nuclear Energy in Everyday Life Nuclear Energy in Everyday Life Understanding Radioactivity and Radiation in our Everyday Lives Radioactivity is part of our earth – it has existed all along. Naturally occurring radio- active materials are present in the earth’s crust, the floors and walls of our homes, schools, and offices and in the food we eat and drink. Our own bodies- muscles, bones and tissues, contain naturally occurring radioactive elements. Man has always been exposed to natural radiation arising from earth as well as from outside. Most people, upon hearing the word radioactivity, think only about some- thing harmful or even deadly; especially events such as the atomic bombs that were dropped on Hiroshima and Nagasaki in 1945, or the Chernobyl Disaster of 1986. However, upon understanding radiation, people will learn to appreciate that radia- tion has peaceful and beneficial applications to our everyday lives. What are atoms? Knowledge of atoms is essential to understanding the origins of radiation, and the impact it could have on the human body and the environment around us. All materi- als in the universe are composed of combination of basic substances called chemical elements. There are 92 different chemical elements in nature. The smallest particles, into which an element can be divided without losing its properties, are called atoms, which are unique to a particular element. An atom consists of two main parts namely a nu- cleus with a circling electron cloud. The nucleus consists of subatomic particles called protons and neutrons. Atoms vary in size from the simple hydro- gen atom, which has one proton and one electron, to large atoms such as uranium, which has 92 pro- tons, 92 electrons. -
Chapter 1.2: Transformation Kinetics
Chapter 1: Radioactivity Chapter 1.2: Transformation Kinetics 200 NPRE 441, Principles of Radiation Protection Chapter 1: Radioactivity http://www.world‐nuclear.org/info/inf30.html 201 NPRE 441, Principles of Radiation Protection Chapter 1: Radioactivity Serial Transformation In many situations, the parent nuclides produce one or more radioactive offsprings in a chain. In such cases, it is important to consider the radioactivity from both the parent and the daughter nuclides as a function of time. • Due to their short half lives, 90Kr and 90Rb will be completely transformed, results in a rapid building up of 90Sr. • 90Y has a much shorter half‐life compared to 90Sr. After a certain period of time, the instantaneous amount of 90Sr transformed per unit time will be equal to that of 90Y. •Inthiscase,90Y is said to be in a secular equilibrium. 202 NPRE 441, Principles of Radiation Protection Chapter 1: Radioactivity Exponential DecayTransformation Kinetics • Different isotopes are characterized by their different rate of transformation (decay). • The activity of a pure radionuclide decreases exponentially with time. For a given sample, the number of decays within a unit time window around a given time t is a Poisson random variable, whose expectation is given by t Q Q0e •Thedecayconstant is the probability of a nucleus of the isotope undergoing a decay within a unit period of time. 203 NPRE 441, Principles of Radiation Protection Chapter 1: Radioactivity Why Exponential Decay? The decay rate, A, is given by Separate variables in above equation, we have The decay constant is the probability of a nucleus of the isotope undergoing a decay within a unit period of time. -
Glossary Derived From: Human Research Program Integrated Research Plan, Revision A, (January 2009)
Glossary derived from: Human Research Program Integrated Research Plan, Revision A, (January 2009). National Aeronautics and Space Administration, Johnson Space Center, Houston, Texas 77058, pages 232-280. Report No. 153: Information Needed to Make Radiation Protection Recommendations for Space Missions Beyond Low-Earth Orbit (2006). National Council on Radiation Protection and Measurements, pages 309-318. Reprinted with permission of the National Council on Radiation Protection and Measurements, http://NCRPonline.org . Managing Space Radiation Risk in the New Era of Space Exploration (2008). Committee on the Evaluation of Radiation Shielding for Space Exploration, National Research Council. National Academies Press, pages 111-118. -A- AAPM: American Association of Physicists in Medicine. absolute risk: Expression of excess risk due to exposure as the arithmetic difference between the risk among those exposed and that obtaining in the absence of exposure. absorbed dose (D): Average amount of energy imparted by ionizing particles to a unit mass of irradiated material in a volume sufficiently small to disregard variations in the radiation field but sufficiently large to average over statistical fluctuations in energy deposition, and where energy imparted is the difference between energy entering the volume and energy leaving the volume. The same dose has different consequences depending on the type of radiation delivered. Unit: gray (Gy), equivalent to 1 J/kg. ACE: Advanced Composition Explorer Mission, launched in 1997 and orbiting the L1 libration point to sample energetic particles arriving from the Sun and interstellar and galactic sources. It also provides continuous coverage of solar wind parameters and solar energetic particle intensities (space weather). When reporting space weather, it can provide an advance warning (about one hour) of geomagnetic storms that can overload power grids, disrupt communications on Earth, and present a hazard to astronauts. -
Reduced Fractionation in Lung Cancer Patients Treated with Curative-Intent Radiotherapy During the COVID-19 Pandemic
This document was published on 2 April 2020. Please check www.rcr.ac.uk/cancer-treatment-documents to ensure you have the latest version. This document is the collaborative work of oncologists and their teams, and is not a formal RCR guideline or consensus statement. Reduced fractionation in lung cancer patients treated with curative-intent radiotherapy during the COVID-19 pandemic Corinne Faivre-Finn1,2, John D Fenwick3,4, Kevin N Franks5,6, Stephen Harrow7,8, Matthew QF Hatton9, Crispin Hiley10,11, Jonathan J McAleese12, Fiona McDonald13, Jolyne O’Hare12, Clive Peedell14, Ceri Powell15,16, Tony Pope17, Robert Rulach7,8, Elizabeth Toy18 1The Christie NHS Foundation Trust, Manchester 2The University of Manchester 3Department of Molecular and Clinical Cancer Medicine, Institute of Translational Medicine, University of Liverpool 4Department of Physics, Clatterbridge Cancer Centre, Liverpool 5Leeds Cancer Centre 6University of Leeds 7Beatson West of Scotland Cancer Centre, Glasgow 8University of Glasgow 9Weston Park Hospital, Sheffield 10CRUK Lung Cancer Centre of Excellence, University College London 11Department of Clinical Oncology, University College London Hospitals NHS Foundation Trust, London 12Northern Ireland Cancer Centre, Belfast 13The Royal Marsden NHS Foundation Trust, London 14James Cook University Hospital, Middlesbrough 15South West Wales Cancer Centre 16Velindre Cancer Centre 17Clatterbridge Cancer Centre, Liverpool 18Royal Devon and Exeter NHS Foundation Trust 1 This document was published on 2 April 2020. Please check www.rcr.ac.uk/cancer-treatment-documents to ensure you have the latest version. This document is the collaborative work of oncologists and their teams, and is not a formal RCR guideline or consensus statement. Introduction The World Health Organisation (WHO) declared COVID-19, the disease caused by the 2019 novel coronavirus SARS-CoV-2, a pandemic on the 11th of March 2020. -
Experimental Γ Ray Spectroscopy and Investigations of Environmental Radioactivity
Experimental γ Ray Spectroscopy and Investigations of Environmental Radioactivity BY RANDOLPH S. PETERSON 216 α Po 84 10.64h. 212 Pb 1- 415 82 0- 239 β- 01- 0 60.6m 212 1+ 1630 Bi 2+ 1513 83 α β- 2+ 787 304ns 0+ 0 212 α Po 84 Experimental γ Ray Spectroscopy and Investigations of Environmental Radioactivity Randolph S. Peterson Physics Department The University of the South Sewanee, Tennessee Published by Spectrum Techniques All Rights Reserved Copyright 1996 TABLE OF CONTENTS Page Introduction ....................................................................................................................4 Basic Gamma Spectroscopy 1. Energy Calibration ................................................................................................... 7 2. Gamma Spectra from Common Commercial Sources ........................................ 10 3. Detector Energy Resolution .................................................................................. 12 Interaction of Radiation with Matter 4. Compton Scattering............................................................................................... 14 5. Pair Production and Annihilation ........................................................................ 17 6. Absorption of Gammas by Materials ..................................................................... 19 7. X Rays ..................................................................................................................... 21 Radioactive Decay 8. Multichannel Scaling and Half-life ..................................................................... -
Cherenkov Radiation
TheThe CherenkovCherenkov effecteffect A charged particle traveling in a dielectric medium with n>1 radiates Cherenkov radiation B Wave front if its velocity is larger than the C phase velocity of light v>c/n or > 1/n (threshold) A β Charged particle The emission is due to an asymmetric polarization of the medium in front and at the rear of the particle, giving rise to a varying electric dipole momentum. dN Some of the particle energy is convertedγ = 491into light. A coherent wave front is dx generated moving at velocity v at an angle Θc If the media is transparent the Cherenkov light can be detected. If the particle is ultra-relativistic β~1 Θc = const and has max value c t AB n 1 cosθc = = = In water Θc = 43˚, in ice 41AC˚ βct βn 37 TheThe CherenkovCherenkov effecteffect The intensity of the Cherenkov radiation (number of photons per unit length of particle path and per unit of wave length) 2 2 2 2 2 Number of photons/L and radiation d N 4π z e 1 2πz 2 = 2 1 − 2 2 = 2 α sin ΘC Wavelength depends on charge dxdλ hcλ n β λ and velocity of particle 2πe2 α = Since the intensity is proportional to hc 1/λ2 short wavelengths dominate dN Using light detectors (photomultipliers)γ = sensitive491 in 400-700 nm for an ideally 100% efficient detector in the visibledx € 2 dNγ λ2 d Nγ 2 2 λ2 dλ 2 2 11 1 22 2 d 2 z sin 2 z sin 490393 zz sinsinΘc photons / cm = ∫ λ = π α ΘC ∫ 2 = π α ΘC 2 −− 2 = α ΘC λ1 λ1 dx dxdλ λ λλ1 λ2 d 2 N d 2 N dλ λ2 d 2 N = = dxdE dxdλ dE 2πhc dxdλ Energy loss is about 104 less hc 2πhc than 2 MeV/cm in water from € -
Hypo-Fractionated FLASH-RT As an Effective Treatment Against Glioblastoma That Reduces Neurocognitive Side Effects in Mice
Author Manuscript Published OnlineFirst on October 15, 2020; DOI: 10.1158/1078-0432.CCR-20-0894 Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Hypo-fractionated FLASH-RT as an effective treatment against glioblastoma that reduces neurocognitive side effects in mice Pierre Montay-Gruel1*, Munjal M. Acharya2*, Patrik Gonçalves Jorge1, 3, Benoit Petit1, Ioannis G. Petridis1, Philippe Fuchs1, Ron Leavitt1, Kristoffer Petersson1, 3, Maude Gondre1, 3, Jonathan Ollivier1, Raphael Moeckli3, François Bochud3, Claude Bailat3, Jean Bourhis1, Jean-François Germond3°, Charles L. Limoli2° and Marie-Catherine Vozenin1° 1 Department of Radiation Oncology/DO/Radio-Oncology/CHUV, Lausanne University Hospital and University of Lausanne, Switzerland. 2 Department of Radiation Oncology, University of California, Irvine, CA 92697-2695, USA. 3 Institute of Radiation Physics/CHUV, Lausanne University Hospital, Switzerland. *, ° contributed equally to the work Running title Sparing the cognition, not the tumor with FLASH-RT Key words FLASH radiation therapy, glioblastoma, neurocognition Financial support The study was supported by a Synergia grant from the FNS CRS II5_186369 (M-C.V. and F.B.), a grant from lead agency grant FNS/ANR CR32I3L_156924 (M-C.V. and C.B.), ISREC Foundation thank to Biltema donation (JB and MCV) and by NIH program project grant PO1CA244091 (M-C.V. and C.L.L.), NINDS grant NS089575 (C.L.L.), KL2 award KL2TR001416 (M.M.A.). P.M.-G. was supported by Ecole Normale Supérieure de Cachan fellowship (MESR), FNS N°31003A_156892 and ISREC Foundation thank to Biltema donation, K.P. by FNS/ANR CR32I3L_156924 and ISREC Foundation thank to Biltema donation; P.J.G. -
Nuclear Radiation 1. an Atom Contains Electrons, Protons and Neutrons
Nuclear Radiation 1. An atom contains electrons, protons and neutrons. Which of these particles a) are outside the nucleus b) are uncharged c) have a negative charge d) are nucleons e) are much lighter than the others? 2. Complete the table below. Name Symbol Charge What is it? Alpha particle β -1 Gamma ray An electromagnetic wave 3. How is an ionised material different from a material that is not ionised? National 5 Physics: Waves & Radiation 1 Absorption of Radiation 1. The figure below shows a Geiger tube used to detect radiation from a radioactive source. thick lead plate 0 4 2 5 start counter stop ON OFF reset Geiger tube radioactive source The following measurements were made using the apparatus above. Counts in 300 seconds Readings Average 1 No source present 102 94 110 2 Source present at fixed distance from tube a) No lead plate present 3466 3420 3410 b) Thick lead plate present 105 109 89 c) Aluminium sheet in place of the 1834 1787 1818 thick lead sheet a) Complete the table by calculating the average readings. b) Why are the readings on each line not the same? c) What can you say from the table about the effect on the radiation of: i. The lead plate? ii. The aluminium plate? d) Why is it possible to say from the readings that: i. gamma radiation is emitted by the source? ii. alpha and beta radiation might be emitted by the source? e) What further tests could you make using this arrangement to find out whether or not the source emits alpha radiation? National 5 Physics: Waves & Radiation 2 2. -
Sources, Effects and Risks of Ionizing Radiation
SOURCES, EFFECTS AND RISKS OF IONIZING RADIATION United Nations Scientific Committee on the Effects of Atomic Radiation UNSCEAR 2016 Report to the General Assembly, with Scientific Annexes UNITED NATIONS New York, 2017 NOTE The report of the Committee without its annexes appears as Official Records of the General Assembly, Seventy-first Session, Supplement No. 46 and corrigendum (A/71/46 and Corr.1). The report reproduced here includes the corrections of the corrigendum. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. The country names used in this document are, in most cases, those that were in use at the time the data were collected or the text prepared. In other cases, however, the names have been updated, where this was possible and appropriate, to reflect political changes. UNITED NATIONS PUBLICATION Sales No. E.17.IX.1 ISBN: 978-92-1-142316-7 eISBN: 978-92-1-060002-6 © United Nations, January 2017. All rights reserved, worldwide. This publication has not been formally edited. Information on uniform resource locators and links to Internet sites contained in the present publication are provided for the convenience of the reader and are correct at the time of issue. The United Nations takes no responsibility for the continued accuracy of that information or for the content of any external website. -
Uranium Fact Sheet
Fact Sheet Adopted: December 2018 Health Physics Society Specialists in Radiation Safety 1 Uranium What is uranium? Uranium is a naturally occurring metallic element that has been present in the Earth’s crust since formation of the planet. Like many other minerals, uranium was deposited on land by volcanic action, dissolved by rainfall, and in some places, carried into underground formations. In some cases, geochemical conditions resulted in its concentration into “ore bodies.” Uranium is a common element in Earth’s crust (soil, rock) and in seawater and groundwater. Uranium has 92 protons in its nucleus. The isotope2 238U has 146 neutrons, for a total atomic weight of approximately 238, making it the highest atomic weight of any naturally occurring element. It is not the most dense of elements, but its density is almost twice that of lead. Uranium is radioactive and in nature has three primary isotopes with different numbers of neutrons. Natural uranium, 238U, constitutes over 99% of the total mass or weight, with 0.72% 235U, and a very small amount of 234U. An unstable nucleus that emits some form of radiation is defined as radioactive. The emitted radiation is called radioactivity, which in this case is ionizing radiation—meaning it can interact with other atoms to create charged atoms known as ions. Uranium emits alpha particles, which are ejected from the nucleus of the unstable uranium atom. When an atom emits radiation such as alpha or beta particles or photons such as x rays or gamma rays, the material is said to be undergoing radioactive decay (also called radioactive transformation). -
Time, Dose and Fractionation: Accounting for Hypoxia in the Search for Optimal Radiotherapy Treatment Parameters
!"#$ #"%"" &&' ( )(' * % ( + % , , %- .( (, , , % , . . % . %* . , . ( . %- ( . (, , , . . % / , 012( , . % 3 , % / , ( , , ( ( % . % , . ( . % , . + ( . , %%1 % - ( . , . 4 #)-*56 . ( . %1 , . ( + , , . % . , % !"#$ 788 %% 8 9 : 77 7 7 #6);"# <1=>$)>#$$>$";#? <1=>$)>#$$>$";!; ! (#"?># TIME, DOSE AND FRACTIONATION: ACCOUNTING FOR HYPOXIA IN THE SEARCH FOR OPTIMAL RADIOTHERAPY TREATMENT PARAMETERS Emely Kjellsson Lindblom Time, dose and fractionation: accounting for hypoxia in the search for optimal radiotherapy treatment parameters Emely Kjellsson Lindblom ©Emely Kjellsson Lindblom, Stockholm University 2017 ISBN print 978-91-7797-031-6 -
Copyright by Arthur Bryan Crawford 2004
Copyright by Arthur Bryan Crawford 2004 The Dissertation Committee for Arthur Bryan Crawford Certifies that this is the approved version of the following dissertation: Evaluation of the Impact of Non -Uniform Neutron Radiation Fields on the Do se Received by Glove Box Radiation Workers Committee: Steven Biegalski, Supervisor Sheldon Landsberger John Howell Ofodike Ezekoye Sukesh Aghara Evaluation of the Impact of Non -Uniform Neutron Radiation Fields on the Dose Received by Glove Box Radiation Workers by Arthur Bryan Crawford, B.S., M.S. Dissertation Presented to the Faculty of the Graduate School of The University of Texas at Austin in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy The University of Texas at Austin December, 2004 Dedication I was born to goodly parents Harvey E. Crawford and Johnnie Lee Young Crawford Acknowledgements I would like to express my gratitude to Dr. Sheldon Landsberger for his vision in starting a distance learning program at the University of Texas at Austin and for his support and encouragement on this quest. I would like to thank my advisor, Dr. Steven Biegalski, for his support and encouragement even though the topic area was new to him. I would like to thank the members of my dissertation committee for finding the time to review this dissertation. To the staff of the Nuclear Engineering Teaching Laboratory I say thank you for your kindness and support during those brief times that I was on cam pus. A special thanks to my past and present group leaders, David Seidel, Eric McNamara, and Bill Eisele and my Division Leader, Lee McAtee, at Los Alamos National Laboratory, for their support in being allowed to use time and material resources at the Lab oratory and for financial support in the form of tuition reimbursement and travel expenses.