Thymoma: Update for the New Millenium
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Advancement in Diagnostic Imaging of Thymic Tumors
cancers Commentary Advancement in Diagnostic Imaging of Thymic Tumors Francesco Gentili 1,*, Ilaria Monteleone 2, Francesco Giuseppe Mazzei 1, Luca Luzzi 3, Davide Del Roscio 2, Susanna Guerrini 1 , Luca Volterrani 2 and Maria Antonietta Mazzei 2 1 Unit of Diagnostic Imaging, Department of Radiological Sciences, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy; [email protected] (F.G.M.); [email protected] (S.G.) 2 Unit of Diagnostic Imaging, Department of Medical, Surgical and Neuro Sciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy; [email protected] (I.M.); [email protected] (D.D.R.); [email protected] (L.V.); [email protected] (M.A.M.) 3 Thoracic Surgery Unit, Department of Medical, Surgical and Neuro Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, 53100 Siena, Italy; [email protected] * Correspondence: [email protected] Simple Summary: Diagnostic imaging is pivotal for the diagnosis and staging of thymic tumors. It is important to distinguish thymoma and other tumor histotypes amenable to surgery from lymphoma. Furthermore, in cases of thymoma, it is necessary to differentiate between early and advanced disease before surgery since patients with locally advanced tumors require neoadjuvant chemotherapy for improving survival. This review aims to provide to radiologists a full spectrum of findings of thymic neoplasms using traditional and innovative imaging modalities. Abstract: Thymic tumors are rare neoplasms even if they are the most common primary neoplasm of the anterior mediastinum. In the era of advanced imaging modalities, such as functional MRI, dual- Citation: Gentili, F.; Monteleone, I.; Mazzei, F.G.; Luzzi, L.; Del Roscio, D.; energy CT, perfusion CT and radiomics, it is possible to improve characterization of thymic epithelial Guerrini, S.; Volterrani, L.; Mazzei, tumors and other mediastinal tumors, assessment of tumor invasion into adjacent structures and M.A. -
Copy Number Aberrations of Genes Regulating Normal Thymus Development in Thymic Epithelial Tumors
Published OnlineFirst February 26, 2013; DOI: 10.1158/1078-0432.CCR-12-3260 Clinical Cancer Human Cancer Biology Research Copy Number Aberrations of Genes Regulating Normal Thymus Development in Thymic Epithelial Tumors Iacopo Petrini1, Yisong Wang1, Paolo A. Zucali3, Hye Seung Lee1,4, Trung Pham1, Donna Voeller1, Paul S. Meltzer2, and Giuseppe Giaccone1 Abstract Purposes: To determine whether the deregulation of genes relevant for normal thymus development can contribute to the biology of thymic epithelial tumors (TET). Experimental Design: Using array comparative genomic hybridization, we evaluated the copy number aberrations of genes regulating thymus development. The expression of genes most commonly involved in copy number aberrations was evaluated by immunohistochemistry and correlated with patients’ outcome. Correlation between FOXC1 copy number loss and gene expression was determined in a confirmation cohort. Cell lines were used to test the role of FOXC1 in tumors. Results: Among 31 thymus development-related genes, PBX1 copy number gain and FOXC1 copy number loss were presented in 43.0% and 39.5% of the tumors, respectively. Immunohistochemistry on a series of 132 TETs, including those evaluated by comparative genomic hybridization, revealed a correlation between protein expression and copy number status only for FOXC1 but not for PBX1. Patients with FOXC1- negative tumors had a shorter time to progression and a trend for a shorter disease-related survival. The correlation between FOXC1 copy number loss and mRNA expression was confirmed in a separate cohort of 27 TETs. Ectopic FOXC1 expression attenuated anchorage-independent cell growth and cell migration in vitro. Conclusion: Our data support a tumor suppressor role of FOXC1 in TETs. -
Einstein Healthcare Network Cancer Center Active
EINSTEIN HEALTHCARE NETWORK CANCER CENTER ACTIVE CLINICAL TRIALS 1 TABLE OF CONTENTS PAGE Studies by Organ/System 3 Brain 4 - 6 Breast – Neoadjuvant/Adjuvant 6 Breast – Advanced/Metastatic 7-8 Gastrointestinal – Colorectal – Adjuvant 9 Gastrointestinal –Advanced, Metastatic 10 Gastrointestinal –Hepatocellular 11 Gastrointestinal –Pancreatic 12-13 Genitourinary – Prostate 14 Gynecological 15-16 Head and Neck 17 Myeloma 18-20 Lung – NSCLC 21-22 Lung – SCLC/Thymoma, Thymic Carcinoma/Mesothelioma 23-24 Supportive care 25 Multiple cancer diagnoses 26 Trials pending activation 27 ECOG Path. Coordinating Ctr Information “NEW” 10/24/2014 2 BRAIN PROTOCOL CONTACTS Radiation Oncology Investigator – Kenneth Zeitzer, MD 215-456-6280 Coordinator – Jeff Mealey, RN 215-456-6316 No active studies at this time. 3 BREAST PROTOCOL CONTACTS MEDICAL ONCOLOGY Investigator – Mark S. Morginstin, DO 215-456-3880 Coordinator – Joann R. Ackler, RN, OCN, CCRP 215-456-8295 RADIATION ONCOLOGY Investigator – Angelica T. Montesano, MD 215-456-6280 Coordinator – Jeff Mealy, RN 215-456-6316 STUDY# TITLE and ELIGIBILITY CRITERIA THERAPY ADJUVANT NRG BR-003/ A Randomized Phase III Trial of Adjuvant Therapy Arm 1: CIRB-005 Comparing Doxorubicin Plus Cyclophosphamide Followed by Doxorubicin 60 mg/M2 IV Weekly Paclitaxel with or without Carboplatin for Node- Cyclophosphamide 600 mg/m2 IV # Pts: _____ Positive or High-Risk Node Negative Invasive Breast Cancer Q 2 Weeks X 4 cycles Eligibility: Unilateral breast IDC: pT1-3; pN0 – pN3b, Followed by: underwent mastectomy or clear margins on lumpectomy/re- Paclitaxel 80 mg/m2 IV weekly x 12 doses excision; ER, PR, & HER2 negative (please see pgs. 14-15 of protocol for specifics). -
Pulmonary in Trisomy 18 (T18) and Has Been Described Also in Several Disorders Other Than T18
ANNUAL MEETING ABSTRACTS 449A 1867 Infections in a Children’s Hospital Autopsy Population abstract, is useful and may serve as a guideline to define CH, with linear regression +20% J Springer, R Craver. Louisiana State University Health Science Center, New Orleans, of T18 cases and/or linear regression -20% of control cases being the borderline for CH. LA. Background: Despite advances in antimicrobial therapy, infections/inflammatory 1869 Expression of Disialoganglioside GD2 in Neuroblastomas of lesions may frequently cause or contribute to death in children. Patients Treated with Immunotherapy Design: We retrospectively reviewed all autopsies performed at a children’s hospital T Terzic, P Teira, S Cournoyer, M Peuchmaur, H Sartelet. Centre Hospitalier from 1986-2009 and categorized infectious complications as 1)underlying cause Universitaire Sainte-Justine, Montreal, QC, Canada; Hopital Universitaire Robert- of death,2) mechanism of death complicating another underlying cause of death,3) Debre, Paris, France. contributing to death 4) agonal or infections immediately before death 5) incidental. Background: Neuroblastoma, a malignant neoplasm of the sympathetic nervous Infectious complications were then separated into 3-8 year groups to identify trends system, is one of the most aggressive pediatric cancers with a tendency for widespread over the years. dissemination, relapse and a poor long term survival, despite intensive multimodal Results: There were 1369 deaths over 24 years, 608 (44%) underwent autopsy at treatments. Recent use of immunotherapy (a chimeric human-murine monoclonal the hospital, another 122 (8.9%) were coroner’s cases not performed at the hospital. antibody ch14.18 directed against a tumor-associated antigen GD2, a disialoganglioside) There were 691 infectious conditions in 401 children (66%, 1.72 infections/infected to treat minimal residual disease has shown improvement in event-free and overall patient).There were no differences in the percentage of autopsies with infections over survival of high-risk neuroblastomas. -
Redalyc.POSTERS EXPOSTOS
Revista Portuguesa de Pneumología ISSN: 0873-2159 [email protected] Sociedade Portuguesa de Pneumologia Portugal POSTERS EXPOSTOS Revista Portuguesa de Pneumología, vol. 23, núm. 3, noviembre, 2017 Sociedade Portuguesa de Pneumologia Lisboa, Portugal Disponível em: http://www.redalyc.org/articulo.oa?id=169753668003 Como citar este artigo Número completo Sistema de Informação Científica Mais artigos Rede de Revistas Científicas da América Latina, Caribe , Espanha e Portugal Home da revista no Redalyc Projeto acadêmico sem fins lucrativos desenvolvido no âmbito da iniciativa Acesso Aberto Document downloaded from http://www.elsevier.es, day 06/12/2017. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. POSTERS EXPOSTOS PE 001 PE 002 A PLEASANT FINDING MALIGNANT CHEST PAIN A Pais, AI Coutinho, M Cardoso, A Pignatelli, C Bárbara A Pais, C Pereira, C Antunes, V Pereira, AI Coutinho, A Feliciano, Centro Hospitalar de Lisboa Norte C Quadros, A Ribeiro, L Carvalho, C Bárbara Centro Hospitalar de Lisboa Norte Key-words: mass, debridement, hamartoma Key-words: pain, S100, sarcoma 37-year-old male patient, salesman. Sporadic smoker. With a past history of allergic rhinitis and chronic gastritis. With no usual 26-year-old male patient, supermarket employee. Smoker of 10 medication. In January 2017, he was diagnosed with a respiratory pack-year. Past history of bronchial asthma in childhood. No rel - infection, having completed ten days of empirical antibiotic ther - evant family history. Without usual ambulatory medication. With apy with amoxicillin / clavulanic acid, with clinical improvement. a history of dry cough and chest pain in the posterior region of In May 2017, he underwent thoracic xray, which revealed homoge - the left hemithorax, for about two years, having had at that time, neous opacity of triangular morphology in the middle lobe of the chest X-ray without pathological findings, and the clinical picture right lung. -
(NCCN Guidelines®) Thymomas and Thymic Carcinomas
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Thymomas and Thymic Carcinomas Version 2.2019 — March 11, 2019 NCCN.org Continue Version 2.2019, 03/11/19 © 2019 National Comprehensive Cancer Network® (NCCN®), All rights reserved. NCCN Guidelines® and this illustration may not be reproduced in any form without the express written permission of NCCN. NCCN Guidelines Index NCCN Guidelines Version 2.2019 Table of Contents Thymomas and Thymic Carcinomas Discussion *David S. Ettinger, MD/Chair † Ramaswamy Govindan, MD † Sandip P. Patel, MD ‡ † Þ The Sidney Kimmel Comprehensive Siteman Cancer Center at Barnes- UC San Diego Moores Cancer Center Cancer Center at Johns Hopkins Jewish Hospital and Washingtn University School of Medicine Karen Reckamp, MD, MS † ‡ *Douglas E. Wood, MD/Vice Chair ¶ City of Hope National Medical Center Fred Hutchinson Cancer Research Matthew A. Gubens, MD, MS † Center/Seattle Cancer Care Alliance UCSF Helen Diller Family Gregory J. Riely, MD, PhD † Þ Comprehensive Cancer Center Memorial Sloan Kettering Cancer Center Dara L. Aisner, MD, PhD ≠ University of Colorado Cancer Center Mark Hennon, MD ¶ Steven E. Schild, MD § Roswell Park Cancer Institute Mayo Clinic Cancer Center Wallace Akerley, MD † Huntsman Cancer Institute Leora Horn, MD, MSc † Theresa A. Shapiro, MD, PhD Þ at the University of Utah Vanderbilt-Ingram Cancer Center The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Jessica Bauman, MD ‡ † Rudy P. Lackner, MD ¶ Fox Chase Cancer Center Fred & Pamela Buffett Cancer Center James Stevenson, MD † Case Comprehensive Cancer Center/ Ankit Bharat, MD ¶ Michael Lanuti, MD ¶ University Hospitals Seidman Cancer Center Robert H. Lurie Comprehensive Cancer Massachusetts General Hospital Cancer Center and Cleveland Clinic Taussig Cancer Institute Center of Northwestern University Ticiana A. -
Cigna Chest Imaging Guidelines
Cigna Medical Coverage Policies – Radiology Chest Imaging Guidelines Effective February 1, 2021 ____________________________________________________________________________________ Instructions for use The following coverage policy applies to health benefit plans administered by Cigna. Coverage policies are intended to provide guidance in interpreting certain standard Cigna benefit plans and are used by medical directors and other health care professionals in making medical necessity and other coverage determinations. Please note the terms of a customer’s particular benefit plan document may differ significantly from the standard benefit plans upon which these coverage policies are based. For example, a customer’s benefit plan document may contain a specific exclusion related to a topic addressed in a coverage policy. In the event of a conflict, a customer’s benefit plan document always supersedes the information in the coverage policy. In the absence of federal or state coverage mandates, benefits are ultimately determined by the terms of the applicable benefit plan document. Coverage determinations in each specific instance require consideration of: 1. The terms of the applicable benefit plan document in effect on the date of service 2. Any applicable laws and regulations 3. Any relevant collateral source materials including coverage policies 4. The specific facts of the particular situation Coverage policies relate exclusively to the administration of health benefit plans. Coverage policies are not recommendations for treatment and should never be used as treatment guidelines. This evidence-based medical coverage policy has been developed by eviCore, Inc. Some information in this coverage policy may not apply to all benefit plans administered by Cigna. These guidelines include procedures eviCore does not review for Cigna. -
Cystic Thymomas and Thymic Cysts a Review
Thorax (1967), 22, 408. Cystic thymomas and thymic cysts A Review N. H. DYER' From the London Hospital, E.I Six cases of large thymic cyst are described; five were cystic thymomas and one was non- neoplastic. Two of the thymomas were not only grossly degenerate but showed severe chronic inflammatory change, so that the diagnosis might be missed. The classification of cysts into congenital, inflammatory, and neoplastic groups is discussed. Cystic teratomata of the thymus, lymphatic cysts, and bronchogenic cysts are classed separately since thymic location does not affect their natural history. Cystic thymomas are still not well known clinically, and the literature on the subject is reviewed. It is probable that quite a few non-specific cysts of the anterior mediastinum are of thymic origin. Tumours of the thymus are not as rare as was TABLE I formerly supposed (Brit. med. J., 1963) although MEDIASTINAL TUMOURS AND CYSTS (1950-65) their relative incidence varies greatly in different series of primary mediastinal tumours and cysts Type of Tumour No. and ranges from 7-5% to 43% (Le Roux, 1961). Neurogenous .36 Benign .30 Thymic cysts, however, have received scant atten- Malignant .. 3 most have failed Neuroblastoma.. 3 tion in the literature and reports Teratoma.11 to emphasize the different varieties of the lesion. Benign. 8 Malignant .. 3 In particular, the tendency to gross cyst formation Thymoma .24 which has been Thymic carcinoma 2 in thymomas, long recognized by Thymic cyst 1 pathologists, is often not appreciated by clinicians. Bronchogenic cyst.. 5 Pericardial cyst. 4 When the cystic element predominates the thymic Lymphatic cyst/lymphangioma.2 of the tumour be missed Haemangioma. -
Exotics Oncology: Special Focus on Updates on Therapies for Rabbits & Ferrets
Exotics Oncology: Special Focus on Updates on Therapies for Rabbits & Ferrets La’Toya Latney, DVM Exotic Companion Animal Medicine Service Penn Vet THYMOMAS IN RABBITS Rabbits possess a persistent thymus, which does not involute with age. The thymus is comprised of thymic epithelium, reticuloendothelial tissue, and lymphoid tissue. Primary thymic neoplasms recognized in rabbits include (1) benign neoplasm of thymic epithelial cells, (2) thymic carcinoma, a rare malignant neoplasm of the epithelial cells and (3) thymic lymphoma, which is a malignant neoplasm of the lymphoid tissue of the thymus. Clinically, thymomas are diagnosed as lymphoid-rich, epithelial-rich, or mixed lymphoepithelial. The incidence in pet rabbits is largely unknown, however in one retrospective study, thymomas comprised 7% of all neoplasms in 55 colony rabbits in rabbits 2-4 years of age in 1949. More recently, in a retrospective evaluation of 1,100 female rabbits more than 2 years of age submitted for necropsy over a 17-year period, 4 cases of the 234 rabbits that had neoplasia were thymomas (Andres 2012). Literary resources are mainly comprised of clinical case reports (Guzman, Kunzel, Pilny, Bennett, Kovalik, Wagner, Quesenberry, Florizoone, Vernau). Based on current literature, there is no specific sex predisposition, but the common age range is 3-10 years of age, with the median age of 6 years (Kunzel, Andres). Certain breeds have been consistently prominent in clinical case reports, including Netherland dwarves and Lionhead rabbits (Kunzel, Andres). Clinical signs commonly include severe dyspnea and nasal flaring, third eyelid protrusion, orthopneic body position, and bilateral exophthalmos due to caval compression resulting in the pooling of blood in retrobulbar venous plexus. -
An Overview on Molecular Characterization of Thymic Tumors: Old and New Targets for Clinical Advances
pharmaceuticals Review An Overview on Molecular Characterization of Thymic Tumors: Old and New Targets for Clinical Advances Valentina Tateo 1 , Lisa Manuzzi 1, Claudia Parisi 1 , Andrea De Giglio 1,2,* , Davide Campana 1,2 , Maria Abbondanza Pantaleo 1,2 and Giuseppe Lamberti 1,2 1 Department of Experimental, Diagnostic and Specialty Medicine, Policlinico di Sant’Orsola University Hospital, Via P. Albertoni 15, 40138 Bologna, Italy; [email protected] (V.T.); [email protected] (L.M.); [email protected] (C.P.); [email protected] (D.C.); [email protected] (M.A.P.); [email protected] (G.L.) 2 Division of Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via P. Albertoni 15, 40138 Bologna, Italy * Correspondence: [email protected]; Tel.: +39-0512142639 Abstract: Thymic tumors are a group of rare mediastinal malignancies that include three differ- ent histological subtypes with completely different clinical behavior: the thymic carcinomas, the thymomas, and the rarest thymic neuroendocrine tumors. Nowadays, few therapeutic options are available for relapsed and refractory thymic tumors after a first-line platinum-based chemotherapy. In the last years, the deepening of knowledge on thymus’ biological characterization has opened possibilities for new treatment options. Several clinical trials have been conducted, the majority with disappointing results mainly due to inaccurate patient selection, but recently some encouraging results have been presented. In this review, we summarize the molecular alterations observed in Citation: Tateo, V.; Manuzzi, L.; thymic tumors, underlying the great biological differences among the different histology, and the Parisi, C.; De Giglio, A.; Campana, D.; promising targeted therapies for the future. -
Coincidence of Thymoma and Breast Cancer and in a 56-Year-Old Female Patient
Case Report Page 1 of 7 Coincidence of thymoma and breast cancer and in a 56-year-old female patient Evangelia Athanasiou1, Electra Michalopoulou-Manoloutsiou1, Mattheos Bobos1, Dimitris I. Hatzibougias1, Paul Zarogoulidis2, Nikolos Katsikogiannis3, Eirini Sarika3, Ilias Karapantzos4, Nikolaos Barbetakis5, Dimitrios Paliouras5, Fotis Chatzinikolaou6, Charalampos Charalampidis7, Ioanna Kougioumtzi3, Alexandros Kolettas8, Andreas Bakas8, Keraso Tzelepi9, Efstratios Kalaitzis9, Kosmas Tsakiridis8 1“Microdiagnostics” Ltd., Thessaloniki, Greece; 2Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Surgery Department (NHS), University General Hospital of Alexandroupolis, Alexandroupolis, Greece; 4Ear, Nose and Throat Department, “St. Luke’s”, Private Hospital, Panorama, Thessaloniki, Greece; 5Thoracic Surgery Department, 6Pathology Department, “Theagenio” Cancer Hospital, Thessaloniki, Greece; 7Department of Anatomy, Democritus University of Thrace, Alexandroupolis, Greece; 8Thoracic Surgical Department, 9Surgical Department, “St. Luke’s”, Thessaloniki, Greece Correspondence to: Paul Zarogoulidis, MD, PhD. Pulmonary Department-Oncology Unit, “G. Papanikolaou” General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. Email: [email protected]. Abstract: We present a case of a 56-year-old female, with a familial history of breast, lung and brain cancer, which revealed a breast tumor, located in the upper outer quadrant of the left breast. During -
Multiple Inflammatory Cytokine-Productive Thyl-6 Cell Line Established from a Patient with Thymic Carcinoma
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Community Repository of Fukui Multiple Inflammatory Cytokine-Productive ThyL-6 Cell Line Established from a Patient with Thymic Carcinoma Kunihiro Inai 1, Kazutaka Takagi 2, Nobuo Takimoto 1, Hiromi Okada 1, Yoshiaki Imamura 3, Takanori Ueda 2, Hironobu Naiki 1, and Sakon Noriki 4 1 Division of Molecular Pathology, Department of Pathological Sciences, 2 Division of Hematology and Cardiology, Department of General Medicine, 3 Division of Surgical Pathology and 4 Division of Tumor Pathology, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan Corresponding author: Kazutaka Takagi, M.D. 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui 910-1193, Japan Phone: +81-776-61-3111, ext. 2296 Fax: +81-776-61-8109 E-mail: [email protected] Running title: Inflammatory Cytokine Productive ThyL-6 Cell 1 Summary Thymic epithelial cells can produce many kinds of cytokines, and interleukin (IL)-6-producing thymic carcinoma cases have been reported. However, a cytokine-producing human thymic tumor cell line has not previously been established. In this paper, we report a novel, multiple inflammatory cytokine-productive cell line that was established from a patient with thymic carcinoma. This cell line, designated ThyL-6, positively expressed epithelial membrane antigen, cytokeratins, vimentin intermediate filament, and CD5, although hematological markers were not present in the cells. Cytokine antibody array analysis showed that the cells secreted several cytokines including IL-1α, IL-6, IL-8, RANTES, soluble TNFα-receptor 1, VEGF, and CTLA into the culture medium.