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Bohari Yaacob, Hazlina Ahmad Hassali, Rosniza Razali , Daryl Jesus Arapoc, Azfar Hanif Abd Aziz, Fazliana Mohd Saaya, Anee Suryani Sued,, Mohamed Zaffar Ali Mohamed Amiroudine, Nor Azizah Marsiddi, Dr. Zainah Adam and Dr. Shafii Khamis Medical Technology Division, Malaysian Nuclear Agency, 43000 Kajang, Selangor, Malaysia BACKGROUND Film-coated pharmaceutical tablet is produced by an organic- based coating system using highly volatile organic solvents Millions of pharmaceutical industry workers had been exposed with these volatile and toxic chemicals Uncoated tablet CMS film coated tablet Therefore, limiting the uses of these chemicals can be circumvented by the introduction of an aqueous-based coating system. Commercialized coated tablet OBJECTIVE NOVELTY To develop environmental friendly coating material for tablet from natural resources (Sago starch) through INNOVATIVE modification Natural based new coating material for tablet ADVANTAGES Features Synthetic based Natural based coating coating (Sago Starch) Film coating process Highly volatile Aqueous organic solvent Cost of production High Low Chemical exposure Highly exposed to None during coating process volatile solvents Control release SEM micrograph, cross-section Aqueous of a coated Tablet (CMS). based coating Taste process masking ECONOMIC & SOCIAL IMPACT USEFULNESS Increase herbal agriculture productivity (NKEA 11) Improve safety among workers in pharmaceutical industries Site Protection Reduce production cost targeting of active ingredients Promotes growth pharmaceutical industries Protection of acid sensitive drugs APPLICATIONS POTENTIAL USERS Natural starch as film coating material Aqueous based coating process Pharmaceutical industries for manufacturing of tablets and capsules For further information, please contact: Director General, Attn: Malaysia Nuclear Agency (Nuclear Malaysia) Dr Shafii Khamis Medical Technology Division Tel : +603 - 8911 2000 BANGI, 43000 KAJANG E-mail: [email protected] Fax : +603 – 8925 3037 SELANGOR For further information, please contact: Director General, Attn: Malaysia Nuclear Agency (Nuclear Malaysia) Dr Shafii Khamis Medical Technology Division Tel : +603 - 8911 2000 BANGI, 43000 KAJANG E-mail: [email protected] Fax : +603 – 8925 3037 SELANGOR .