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Don T Turn Your Back on the Symptoms of Psychosis: a Proof-Of View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by University of Birmingham Research Portal Don’t turn your back on the symptoms of psychosis : a proof-of-principle, quasi-experimental public health trial to reduce the duration of untreated psychosis in Birmingham, UK Connor, Charlotte; Birchwood, Maximillian; Palmer, Colin; Channa, Sunita; Freemantle, Nick; Lester, Helen; Patterson, Paul; Singh, Swaran DOI: 10.1186/1471-244X-13-67 License: Creative Commons: Attribution (CC BY) Document Version Publisher's PDF, also known as Version of record Citation for published version (Harvard): Connor, C, Birchwood, M, Palmer, C, Channa, S, Freemantle, N, Lester, H, Patterson, P & Singh, S 2013, 'Don’t turn your back on the symptoms of psychosis : a proof-of-principle, quasi-experimental public health trial to reduce the duration of untreated psychosis in Birmingham, UK', BMC Psychiatry, vol. 13, no. 1, 67. https://doi.org/10.1186/1471-244X-13-67 Link to publication on Research at Birmingham portal Publisher Rights Statement: Eligibility for repository : checked 11/03/2014 General rights Unless a licence is specified above, all rights (including copyright and moral rights) in this document are retained by the authors and/or the copyright holders. 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BMC Psychiatry 2013, 13:67 http://www.biomedcentral.com/1471-244X/13/67 STUDY PROTOCOL Open Access Don’t turn your back on the symptoms of psychosis: a proof-of-principle, quasi-experimental public health trial to reduce the duration of untreated psychosis in Birmingham, UK Charlotte Connor1,2*, Max Birchwood3,4, Colin Palmer1, Sunita Channa1, Nick Freemantle5, Helen Lester6, Paul Patterson2,7 and Swaran Singh8 Abstract Background: Reducing the duration of untreated psychosis (DUP) is an aspiration of international guidelines for first episode psychosis; however, public health initiatives have met with mixed results. Systematic reviews suggest that greater focus on the sources of delay within care pathways, (which will vary between healthcare settings) is needed to achieve sustainable reductions in DUP (BJP 198: 256-263; 2011). Methods/Design: A quasi-experimental trial, comparing a targeted intervention area with a ‘detection as usual’ area in the same city. A proof-of–principle trial, no a priori assumptions are made regarding effect size; key outcome will be an estimate of the potential effect size for a definitive trial. DUP and number of new cases will be collected over an 18-month period in target and control areas and compared; historical data on DUP collected in both areas over the previous three years, will serve as a benchmark. The intervention will focus on reducing two significant DUP component delays within the overall care pathway: delays within the mental health service and help-seeking delay. Discussion: This pragmatic trial will be the first to target known delays within the care pathway for those with a first episode of psychosis. If successful, this will provide a generalizable methodology that can be implemented in a variety of healthcare contexts with differing sources of delay. Trial registration: http://www.controlled-trials.com/ISRCTN45058713 Keywords: Public mental health campaign, First-episode psychosis, Early detection, Duration of untreated psychosis, Youth mental health Background which DUP exceeds three months, defines a critical point International studies have shown that the average length after which the likelihood of poorer outcome begins to of time from the onset of psychotic symptoms to first increase, and several studies indicate that accessing treatment (duration of untreated psychosis; DUP) ranges treatment within the first 6 months of onset is a key in- between 364 and 721 days [1] with recent meta-analyses dicator of outcome, specifically in terms of treatment re- reporting an association between long DUP and poor sponse [3-8]. outcome at 6 and 12 months, for both symptoms and Evidence for the efficacy of initiatives to reduce DUP, quality of life. Drake et al. [2] suggest that the point at however, is mixed [9]; the ‘TIPS’ study in Norway has had the greatest success. Their prospective trial in a * Correspondence: [email protected] defined health care region, incorporating the introduc- 1CLAHRC, Birmingham & Solihull Mental Health Foundation Trust, 66-68 Hagley Road, Birmingham B16 8PF, UK tion of an early detection program alongside a public 2School of Psychology, University of Birmingham, Edgbaston, Birmingham health awareness campaign, achieved significant results B15 2TT, UK in comparison with parallel health care areas without an Full list of author information is available at the end of the article © 2013 Connor et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Connor et al. BMC Psychiatry 2013, 13:67 Page 2 of 6 http://www.biomedcentral.com/1471-244X/13/67 early detection program. DUP was significantly shorter (CMHT), delays were greatly extended. These findings and associated with better clinical status and reduced suggested that whilst improvements in help-seeking be- suicide risk at baseline and negative symptoms at 12 havior are necessary, significant improvements within months, with positive effects on clinical and functional mental health services themselves would be essential to status maintained at 5 year follow-up [10]. However, reduce DUP. In Birmingham, as part of the present similar public health initiatives in Australia [11] and study, a youth access pathway into the mental health Canada [12] have failed to demonstrate any impact on service has been developed within the CMHT [20], pro- DUP. viding a single referral point and ensuring that first epi- Implementation of a TIPS style intervention in UK sode cases of psychosis are managed in a youth sensitive healthcare settings, however, may prove ineffective as framework and guarantee direct access to the specialised the care pathway delays experienced by young people service. with first-episode psychosis in UK may not be directly comparable to those experienced in Norway. Rogaland Hypothesis County is a dispersed population centred around the The primary hypothesis to be tested is whether imple- predominantly Caucasian (95%) city of Stavanger [13]; mentation of a psychosis public health campaign in approximately 60% of the population living in urban addition to the youth access pathway for first episode areas [14]. In contrast, Birmingham, UK is the second psychosis, will significantly reduce DUP. most populous city in Britain (1.05m) and the ‘youngest city in Europe’ with 40% of its population under the age Methods of 20. It has a high degree of cultural and religious diver- Design sity, including 68% White British residents, 20% This is a quasi-experimental, proof-of-principle pro- residents of Asian or Asian British heritage and 7% Black spective trial comparing an intervention area in the or Black British, and includes the highest number of south of the city, to the non-intervention remainder of residents from the Muslim faith in any UK local area for the city. whom help-seeking can include imams at the family Incident cases of first episode psychosis from these mosque; indeed, our recent study showed that religious areas will be determined and their DUP and care construction of psychosis is common [15]. pathways ascertained over the following 18 months. We In the UK, the widespread adoption of early interven- also benefit from recent historical DUP data (National tion in psychosis teams (EIS) have not led to a reduction EDEN) [19] for both target and control areas. in DUP [16,17]; this is, perhaps, not surprising since these teams are not resourced or equipped with any Sampling community focused early detection function. Birming- Birmingham is served by a single mental health service, ham, UK, was the setting of the first early intervention which served as the ‘blueprint’ for the Government’sNa- service in the UK, yet despite this it continues to experi- tional Service Framework for Mental Health [21]; it has ence long DUP [18]. Our cluster randomized trial to im- a number of community services including Home Treat- prove early detection of psychosis focusing on primary ment and Assertive Outreach teams, including well- care [16] did not achieve reductions in DUP; further ana- developed early intervention services for first episode lysis revealed that the main sources of delay occurred else- psychosis which were the forerunner of such services where in the care pathway, in particular, within mental across England.
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