THE MEDICAL JOURNAL OF AUSTRALIA. VOL. I.-8TH YEAR. SYDNEY : SATURDAY, MAY 7, 1921. No. 19.
FOCAL INFECTION AND ITS LIMITATIONS.' Lions are active and they have little chance of survival within the body from the action of the acid gastric By Sydney Pern, M.R.C.S., L.R.C.P. (Eng.), Honorary Physician to Out-Patients, St. Vincent's Hospital, secretions. Melbourne. It has been found that if bacteria gain entrance The present subject under review is "Focal In- during the quiescent stage of the stomach, such as by fection and its Limitations." This subject is much drinking water containing bacteria on an empty stom- discussed at the present time and a good deal of ach, they pass rapidly into the alkaline or neutral excellent experimental work has been done to bear it duodenum and can thrive and increase below that out, but there are still many points which the clinician point. It requires many thousand times the num- feels to be true but is unable to prove. Results of ber of bacteria to infect an animal by the stomach treatment on certain lines warrant his belief and as by the respiratory tract. To infect an animal under such conditions he should not be considered with cholera by the stomach it is necessary to neu- to have over-stepped the bounds of propriety hi an- tralize the acidity and also arrest all peristaltic move- nouncing them. There are many who hold the same ments. Much infection is also acquired by elderly views as myself ; to them this will be uninteresting females kissing babies and by children putting things reading, but there are many who, from want of oppor- in their mouths to suck. tunity, do not or whose resistance requires overcom- So on the whole the body is fairly well guarded ing by fair argument. In reviewing this subject from infection viâ the alimentary tract. The typhoid from a broad aspect it may be necessary to repeat bacillus is the exception. certain statements which have appeared in a previous Having excluded all other points of entrance we article bearing on this subject and for which I crave are left with the respiratory tract. A healthy nose your tolerance. has been provided by Nature with certain mechanisms I think in dealing with this question it would best to entrap and get rid of bacteria within reason, but be divided into primary and secondary focal infec- any condition which produces mouth breathing, opens tions and their results. a door at which there is only a second line of defence Primary Focal Infections. available. So it comes about that mouth breathers have It is necessary to have a clear idea in one's mind a very much greater chance of bacteria gaining en- of the methods of entry by bacteria into the body trance to their bodies than others. Bacteria which in relationship with primary focal infections and escape being trapped on the nasal mucosa, must im- to differentiate them from secondary focal infections. pinge on the naso-pharyngeal wall which is freely The primary ones are few and well defined. Bac- supplied with lymphoid tissue. Bacteria entering teria have to gain entrance either by the orifices by the mouth must impinge on the fauces and of the body or by the skin or mucous membranes. pharynx, where the second line of defence, the ton- sils, is situated. We, therefore, find a strong barrier The skin in. the sound state does not readily permit of invasion and if it does so, the infection remains erected as protection at the entrance of the lungs in localized or is destroyed. The outlets, such as the a mass of lymphoid tissue. This, up to a certain anus and urethra, from their functioning as such point, is capable of dealing with organisms. But are not so likely to be portals of entry as the inlets. there comes a time when this defensive mechanism, The urethra has its special infecting agent—the gono- either as a result of atrophy or of overwhelming in- coccus. The conjunctival mucous membrane has its spe- fection, is no longer of any use and instead of destroy- cial infecting organisms as well as those which may set ing bacteria, it allows of their actually multiplying up generalized infection viâ the lachrymal duct and within the tonsils and adenoid tissue. From this sac. The mouth and nose remain and from their time on they are a source of danger, as from here functioning as inlets, must be responsible for the they gain entrance to the blood and lymphatic stream entry of the great majority of bacteria into the and may cause widespread damage. The mucosa lin- system. The nasal mucous membrane has been ing the trachea and bronchi also have a good protect- adapted to trap bacteria and warm the inspired air. ing mechanism in the ciliated epithelium which sweeps The hairs, the large area of secreting mucous mem- all secretions, etc., upwards. This is the chief prim- brane; the solidifying and drying of the secretion, ary focal infection particularly in the young. Infec- are all Nature 's methods of preventing the access of tion of the nasal mucosa is another and is not so harmful bacteria to the body. The mouth in health frequently recognized as such. It is likely to come is opened to talk and to eat. Of the two, more bac- about when the drainage of the nose and accessory teria are liable to gain entrance during the latter sinuses is in some way interfered with by deflected than the former. In abnormal conditions the mouth septum, etc., and an actual sinusitis occurs. In its is used for breathing and in this condition bacteria uncomplicated condition it is recognized by frequent have no protective mechanism to overcome to gain colds in the head and the result of bacteriological. an entrance. If bacteria gain an entrance by food, examination. Infection of the lachrymal sac may be it is chiefly during such a time as the gastric secre- by the nose or conjunctiva and is a primary. focus, as is middle ear disease. These are the primary in- 1 Read at a Meeting of the Victorian Branch of the British Medical Association on February 2, 1821. fective foci of the young.
378 T>EÍÈ MËt)ÍCAt trOtï>tNAiJ OP AtTST11AIúÌA. [May 7, 1921.
Pyorrhoea and root abscesses are usually those of root of a tooth, gall-bladder infections or a part later years. Prostatitis starting as a Neisserian in- which is injured or subjected to irritation by a for- fection and becoming mixed leads to a focus closely eign body. Bone disease is often metastatic in origin resembling that . of the tonsils in its crypt forma- and may lead to secondary focal points. tion. It is responsible for more trouble than is gen- Secondary Focal Infections. erally recognized. Pyelitis is a secondary focal infection, as bacteria In all primary and secondary foci bacteria are cap- can only gain access to the kidney by the blood or able of multiplying in situ, but the secondary focus lymphatic stream, except in the rare occasion when is not capable of arising without a primary one being it is carried there by a ureteral catheter; even in present, as it is metastatic in origin. If bacteria so-called ascending infection from the bladder, the leaving a primary focus locate themselves in such a infection is carried by lymphatics along the course of
position or on tissue whose vitality is somewhat the ureter and not by the ureter itself. It is . doubtful lowered, they may be able to resist the phylactic pro- if the Bacillus coli is alone responsible for pyelitis perties of the blood and tissues. even in cases where no other organisms can be found. Of this we see an example in chronic cholecystitis, Two cases recently under my care in which it was which may remain active after the primary focus the only organism found, did not clear up till septic which has produced it, has ceased to exist or has been tonsils had been removed. The Bacillus coli is rather removed. The same may be true of chronic appendi- like the jackal and hyena in its habits. It allows citis, but as I have not had the question of appendi- others to go in and do the damage ; then it swarms citis under review until recently, I have not had the in to the feed. It is open to question if it is capable opportunity of reviewing the results of removal of a of gaining a hold in undamaged tissues. Infected primary focus in preventing further attacks. It will, tubes, though usually involved by direct extension however, have to be a point for serious consideration from below, may be involved by metastatis as in in the milder types. tuberculosis. All such secondary . focal points are As has been pointed out these localities are not equally as harmful as the primary foci ; they are easy of infection via the stomach, but are chiefly capable of shedding .bacteria into the blood and lym- metastatic in origin. phatic stream. - With the irritation of a concretion in an appendix When an ec-phylactic focus has been established, it is feasible that the Bacillus coli is capable of caus- what results to the bacteria which are incubated ing appendicitis without a primary focus being within it â This will be governed largely by the state present. of the phylactic properties of the blood and by the About a year ago Sir Almroth Wright published virulence of the bacteria. If some immunity has in The Lancet some views and experiments on infec- been established, the reaction will be moderate. This tion and to make matters easily explainable he coined again may be modified by any factor which tends to some new expressions. He describes the defensive reduce the general vitality, such as fatigue, lack of food, etc.. Take an extreme case, with which all mechanisms of the organism against bacterial " in- fection as "phylactic power" and the leucocytes and are familiar, a fatal septicæmia following child-birth bacterio-tropic substances in the blood fluids as or abortion. Here the virulence of the infection is "phylactic agents." The provision for the transport overwhelming and the phylactic properties of the of leucocytes and bacterio-tropic • agents is named blood are unable to destroy the invading hosts, which "kata-phylaxis." The reserves held at a distance are then at liberty to multiply in the blood stream. and available as reinforcements are "epi-phylactic In addition to the original ec-phylactic focus, the response" and Wright substitutes the term "apo- uterus, the whole body becomes an ec-phylactic area. phylactic phase" for "negative phase." An "ec- The next stage is seen in pywmia, where there is some phylactic region" is a focus in which bacteria are resisting power of the phylactic agents, as it is only able to multiply within the body by : here and there that an ec-phylactic or secondary focus is formed resulting in temporary abscesses. (a) Radiating out toxins which will (when of sufficient strength) repel leucocytes. This condition, then, offers a great resistance to the inva- sion which may end either way, by destruction of the (b) By absorbing bacterio-tropic substances from the blood fluid ; and, probably, host or by complete defeat of the invading hordes. (c) By abstracting anti-tryptic power from the The old "laudable pus" indicated that the battle was fairly even and denoted good phylactic powers. blood fluids and so converting these into a congenial culture medium. A further step is seen when the infection is not quite so severe, as in rheumatic fever. Here you do Ec-phylactic foci may become established by exu- not find fresh ec-phylactic areas established, but an dation of fluid, as leucocytes cannot swim, but creep invasion of bacteria with which the phylactic powers along the trellis-work of the tissues. of the body do battle. The fight is fierce and is in This work was done in relation with sepsis during the open; they meet on an equal footing and not under the war, but its application is very suitable to disease the same conditions as when the 'phylactic properties in general as found in civil practice. of the blood are attacking an entrenched or fortified The primary or secondary focus is an ec-phylactic ee-phylactic focus. Here also the phylactic proper- one. These foci are only capable of forming under ties of the tissues as well as the blood can be brought such conditions as Sir Almroth Wright describes, into play. The areas where the bacteria lodge and but locality and environment help • them materially, do battle, can be called machean areas (A 1907, battle). e.g., any part where the circulation is difficult of access, There is evidence to suggest that in these cases they are such as ' a bony cavity, at' the root or even within the not able to multiply and cause further spread of the. con-
May 7, 1921.] THE MEDICAL JOURNAL OF AUSTRALIA. 379
dition, or, if they are able to, it is only for a very been aware that there is anything the matter with brief period, if the patient is going to live. The clini- him If this is the case and we know it to be true, cal evidence in support of this view is as follows: we can dimly realize what may be going on within With a flare up of the ec-phylactic focus there is a the body, when we see pyorrhoea or any other focal corresponding flare up in the joints, if joints are the infection in a patient. tissues involved. With a removal of the ec-phylactic It is well to dwell upon this point because so much focus in the majority of cases the joints clear up and harm is done quietly and insidiously ; nothing worth cease to be involved after a certain period of time. complaining about is noticed until gross damage is Also in the more chronic cases there is the difficulty done. Every tissue of the body is capable of being of cultivating bacteria from these regions. What invaded ; none can claim immunity. This is a big goes on in these "machean" areas is well portrayed statement to make and covers a big field of diseases. by Adami in his work on inflammation. At present it has not been established exactly to There is no pus formation in these cases because what extent there is a bacterial invasion in cer- hordes of white cells have not had to lay down their tain tissues or if the bacterial toxins circulating in lives. Those that are put out of action are quickly the blood possess a selective affinity for these tissues, digested by the connective tissue and endothelial such as is known to exist in several diseases, viz., cells. Only in pyemia where ec-phylactic areas are tetanus, diphtheria and botulism, but the tendency is formed, do we get pus formation. inclining towards the view of direct invasion. The streptococcus in some form or other is respon- Already many have recognized the implication of sible for the majority of complaints of this nature. focal infections in various diseases, arthritis, valvu- Rosenow has shown the transmutability of practically litis, myocarditis, nephritis, neuritis, cholecystitis, all the forms of streptococci up to a pneumococcus appendicitis, herpes, chorea, pancreatitis, erythema from one culture and back again to the origin. In nodosum, spinal myelitis, irido-cyclitis and phlebitis. relationship with this faculty of transmutability an Others besides myself are including goitre in the cate- interesting point arises. If transmutability is pos- gory. Alveolitis of the lung and chronic bronchitis sible in vitro, we can with a fair degree of safety must be added to the list. Certain skin diseases, such assume it equally possible in vivo. Take the case of as eczema, are coming under suspicion Anemia is rheumatic fever, which is caused by a streptococcus. frequently of septic origin. Diabetes has been shown As transmutation takes place through its different so often of late to be associated with gross focal in- phases, no particular harm may occur until it reaches' fections or syphilis and such good results have fol- the stage called Micrococcus rheumaticus, when an lowed the removal of the foci, that the suggestion acute attack of rheumatic fever may occur. When seems to be jixstified that the cause is a focal or specific this is over, it will not occur again till the cycle of infection. No tissues of the body are immune. There transmutability has again come round to the same are cases of epilepsy, often of a Jacksonian type, in point. I explain in this way the failure in the past which an operation has been performed in the hope to find this particular organism in the tonsils, joints, that a removable cause may be found. The finding except during an attack of fever, but not before or is usually a thickened dura. These cases are after. not necessarily specific. There is no other ex- If we apply this story to every tissue of the body, planation than that the thickening is the result of as none can claim immunity, we shall see what an bacterial invasion. There is no reason to assume the cortex cerebri appalling list of diseases are the result of these seem- to be free from bacterial invasion. The ingly harmless factors. question may be asked : What would one expect to find clinically as the result of such invasion ? Epi- To what extent does this warfare go on unknown lepsy suggests itself. In the more acute type of in- to patients and physicians ? Imagine a few bacteria fections cerebritis, abscess and meningitis develope, passing into the blood stream from a tonsil and lodg- while in the milder type symptoms are less severe. ing in the myocardium. They are attacked and A comparison may be drawn between a pyvemic joint beaten. Warfare cannot take place without a cer- and slight rheumatism ; invasion takes place in each tain amount of devastation. A number of muscle condition. Unfortunately once damage is done and cells will be destroyed, but the patient knows nothing fibrous tissue deposited, since this appears to be the of this. Let us suppose that this goes on day after end result of bacterial invasion, removing a septic day and that the patient is suffering from bacterial focus will not cure the disease. In every case of epi- toxemia. He may feel "off colour" and develope lepsy I have seen during the last few years, the blood an extra systole or two. A few may lodge in serum yielded a positive Wassermann reaction or his kidneys and destroy some cells there; he will not there was some gross septic focus. Simple pleurisy experience any discomfort. If this goes on for a is not uncommonly due to metastasis from a focal few years, a few cells destroyed here and there, he infection. Lumbago, sciatica, myalgia, chronic enter- will feel just out of sorts and in need of a holiday, till itis, paralysis agitans, arterio-sclerosis and pos- one day he goes to his medical adviser, who finds he sibly disseminated sclerosis are amongst others. has a leaking valve, a good deal of myocardial damage The deficiencies and excesses of some of the and a high blood pressure. An organ must be very internal secreting glands may owe their origin to grossly damaged before it shows signs of failing All the same cause. It is only a matter of the bacteria this takes place quietly and unknown to the patient having a selective affinity for such tissues. It is not until signs of its failure make him seek for advice. Over half of each of his kidneys may be put out of enough to say that the diseases may be due to a focal action and infection, but we have to accept the fact that in the yet neither he nor his doctor may have great majority they cannot exist without one. If
380 THE MEDICAL JOURNAL OF AUSTRALIA [May 7, 1921.
focal infections could be eradicated, suffering human- is not too soon to put these views into practice and ity would be relieved of half the ills to which flesh save the growing generation from wreckage of body is heir. If venereal diseases, tuberculosis and focal which we now know will eventuate if focal infections infections were eradicated, there would be compara- are allowed to remain. tively few diseases left to plague people living in tem- Ala perate climates. It is on these lines that preventive EMBRYOLOGICAL SPECIMENS OF CLINICAL medicine would accomplish most good. Only a few INTEREST. adult people of the world are free from some primary or secondary focus; their bodies are slowly undergo- I. ing some degenerative changes which might have A CASE OF TWIN TISBAL PRE(NANCY. been or still are preventible. The eradication of some focal infections is simple, of others it is difficult or By John I. Hunter, M.B., Ch.M.. it may be impossible. Sinusitis is often disappoint- Associate Professor of Anatomy, Sydney University. ing, but if free drainage is established and the pa- Though twins and even triplets have been definitely tient put under the best conditions, time and patience established to occur in tubal pregnancies, nevertheless may establish a cure. There is a brighter outlook the following case of twin tubal pregnancy is worthy for the future generation than the last. Many of of record on account of the comparative rarity of the the diseases with which we are so familiar, will cease condition and because of certain associated embryo- to exist. There will be no more rheumatoid arthritis, logical features of clinical interest. no more heart disease except specific cases and we I wish to express my indebtedness to Dr. R. Gordon hope in time these will also soon cease and so along Craig, Sydney, who forwarded the specimen to the the line, if these views are established and acted on. Medical School, Sydney University. It was removed It is only necessary tq apply these views to a large by him at operation, the note accompanying the spe- hospital medical clinic and the results will be cimen stating that it was "a six weeks' abdominal I1 astounding. pregnancy which had ruptured through the Fal- { I found 58% of people seeking medical treatment lopian tube 1.8 cm. from the right cornu of the are suffering from diseases due to obvious focal in- uterus." On further inquiry, it was ascertained that, fections and many more from diseases concerning clinically, the case was one of ectopic pregnancy with which I am hesitating about including in the same no unusual features. On examination of the mass re- category. Let this always be in your mind • These moved at operation, it was found to consist of a uter- things cannot exist without a focal infection being ine tube and two distinct chorionie vesicles of un- present. It is futile to try to treat a patient with the equal size. focal infection remaining, if it is removable. Who Tuba Uterina. can look lightly on a focal infection when such de- The tube, 6.8 cm. in length, was extremely tortuous. vastation and wreckage follows in its wake ? Why The fimbriated extremity was apparently healthy and look outside for the raiders when we are housing the ostium abdominale patent. At its uterine end the them all the time ? Why look for mythical causes tube was ragged and incomplete ; it was found at which have been handed down to us, when we have the operation that the rupture had taken place at such a concrete one and one which is so simple and this site. Elsewhere the wall of the tube was intact. easily understood I Are not most causes of disease This rupture was quite unlike that found in Cam- simple when found out ? These views are more or eron's case (1) of twin tubal pregnancy, where there less accepted.. by many, but to many they are only was only a slight perforation, which was the source partly known - and there are many who openly scoff of profuse haemorrhage. Through this the villi could at them. Let all look for themselves and what they be seen projecting. In the case reported by Child (2) will find will surprise them, for it is written in large there were two distinct perforations in the tube. type that he who runs, may read. The proof will be Sections of the tube taken from the site of rupture in the results obtained. What are the limitations of were examined and the lumen was found to be intact. these views? They cover all the tissues of the body. The outer aspect of the wall was ragged over a con- There are few things which can damage body cells siderable area, indicating that the vesicles had become but bacteria. What are the limitations of treatment ? embedded and had then passed outwards through the Where it is possible to remove the ec-phylactic focus, wall to the peritoneal cavity. results are good ; where not, doubtful. The Twin Chorionic Vesicles. Vaccines have been used indiscriminately in the As already stated, there were found two distinct past and consequently with varying success. Where chorionie vesicles. Cameron made an opening through it is possible to remove the focal infections, vaccines the tube in his case and in doing so separated two are very useful to hasten recovery and may just turn embryos from one another. These had separate am- the balance in the patient's favour. But, against niotic vesicles, but the umbilical cords were united the entrenched focus itself vaccines are of little avail where they entered the placental region. The twins and will only help to alleviate the symptoms of the were evidently uniovular, whereas in the case being patient. There is hope ahead of being able to get more described, the vesicles represented the products of potent vaccines by detoxication and other methods fertilization of two separate ova. which may be able to eradicate the infective focus It has been noted that the ehorionic vesicles were itself. of unequal size. The larger vesicle (H233, Sydney This subject has been dealt with on broad lines. University collection) measured 3.8 X 2.8 X 1.7 cm.. I realize that there is yet much to be done, but it These measurements included the villi, which coin- May .7, 1921.] THE MEDICAL JOURNAL OF AUSTRALIA. 381
pletely surrounded the external surface of the vesicle is an example of an ovum from an ovary of one side (Figure I.B.). The villi varied in length from 3 mm. passing after fertilization to the opposite tube in order to 7 mm. and were freely branching. The dimensions to reach the uterus ; in this instance, the tube on one side and the ovary on the other had been previously removed. Williams (loc. cit.) states 'that in a con- siderable number of cases examined by him, the corpus luteum was placed, not in the ovary corre- sponding to the pregnant tube, but in the opposite one. Shattock (5) , in commenting upon Robson's case of primary ovarian pregnancy, declared that the tube on the same side as the pregnancy was in such a condition that the sperm must have travelled to the ovary through the opposite tube. The true explanation of the apparent difference in the age of the vesicles in this ease of twin tubal pregnancy was, however, forthcoming on examina- tion of the embryos after incision of the chorionic vesicles. The larger chorionic vesicle (H 2 ) presented the usual smooth glistening interior. Attached by an umbilical cord, 7 mm. in length, was an embryo of normal external form (Figure II.a.) . A small FIGURE I.. The Chorionic Vesicles from a Case of Twin 'finial Pregnancy : (a) Left yolk sac and a slender yolk stalk were present. the H 4, (b) Right HZS3. latter being partly incorporated in the umbilical cord. When first exposed, the amnion was closely of the vesicle indicated a period of gestation of prob- investing the embryo. The sitting height (vertex- ably six weeks' duration. breech length) of this embryo was found to be 14 mm., The smaller specimen (H234) would have been con- again indicating a period of gestation between the sidered to have been of a shorter period of develop- sixth and seventh week. Combined with the clinical ment than H, if calcu- lations had been confined to the external dimensions of the chorionic .vesicle (1.8 X 1.6 X 0.7 cm.). These measurements corre- spond to those of a period of gestation of four weeks' duration. Branching villi (maximum length, 3.25 mm.) occurred in patches on the surface of the ves- icle and, though sparse, they were developed on all its aspects. An explana- tion of the disparity of size, which suggested itself at this stage of the examina- tion, was that the two ova had been fertilized at dif- ferent times, one a fort- night later than the other. This could occur even in the event of the already pregnant tube becoming im- passable to spermatozoa. FIGURE II.. Whitridge Williams (3), Interior of the Chorionic Vesicles of (a) Left H. 4 and (b) Right 11.4. for instance, has described a case in which there was a lithopædion at the uterine diagnosis, these facts appear to indicate that the rate end of the right tube. A twin pregnancy developed of development of both chorionic vesicle and embryo in this tube as the result of the addition of another in this case had been normal. fertilized ovum in the following manner : A sper- The interior of the smaller chorionic vesicle (11 224 ) matozoon passing through the left tube fertilized an presented an appearance in marked contrast to that ovum from the left ovary in which the corpus luteum seen in 11233. The surface was dull and discoloured was found. The fertilized ovum then passed to the and strands of fibrinoid material (probably diseased right side, entered the tube and developed on the magma reticulare) bridged the wall and formed proximal side of the lithopædion. Fransden's case (4) trabeculœ upon it. A careful search failed to reveal 382 THE MEDICAL JOURNAL OF AUSTRALIA. [May 7, 1921.
an embryo; it would have been, if normally devel- (5) Shattock, S. G.: Brit. Med. Journ., Pt. 2, 1902, p. 1447. oped, of 2 mm. to 3 mm. vertex-breech length. This (6) Mall, F. P.: Quoted by Williams (loc. cit.). (7) Mall, F. P.: Keibel and Mall's "Manual of Human indicates that the chorionic vesicle in the case of 11 234 Embryology: The Pathology of the Ovum,"' Pt. 1. was in a state of arrested development and that the (8) Giacomini: Quoted by Mall (7). embryo had 'already become converted into an un- recognizable mass or had been absorbed. It is most
probable that both 11 233 and 11 234 are the result of Reports of eases. the fertilization of two ova at the same time, that A CASE OF MALARIA INFECTED IN THE RIVERINA, they are, in effect, of the same age. It is natural to NEW SOUTH WALES. expect that abnormal and arrested development is more common in tubal than in uterine pregnancies. By Harry J. Clayton, M.B., Ch.M., The complication of twins would tend to increase this Honorary Assistant Physician, Royal Prince Alfred Hospital, tendency, as in this case. Sydney. In Mall's series (6) of 117 extra-uterine preg- PATHOLOGICAL INVESTIGATION. nancies, 86% were abnormal. Moreover, a certain percentage of all specimens consist of an ovum with- By Leslie Utz, M.B., Ch.M., out an embryo. His, however, did not recognize a Sydney. class of pathological ovum in which the embryo was We beg to report having investigated and established the destroyed entirely, for, as Mall (7) states, he had diagnosis in a case of malaria in which the only possible "never seen a human ovum without an embryo." district of infection can have been the Riverina. Giacomini (8) and Mall (7) had a different experi- For the earlier portion of the clinical history, for the ence. The former based his classification upon the opportunity of seeing the patient and for a suggestion of the diagnosis we are indebted to Dr. Weedon, of Wagga, New absence or presence of an embryo, while the latter South Wales. The history and clinical notes are as follow: found that 28% of his pathological ova contained Mrs. M., aged 33, domestic duties, married to a farmer at no embryo. Rosewood, • 20 miles from Tumbarumba, vici Wagga. The of our series, a specimen received from Dr. patient has never been farther north than Sydney. For six 11222 years she has not been farther north than Narrandera, in L. J. Shortland, Sydney, illustrates clearly such an the Riverina district, where she äspent some months prior occurrence in uterine pregnancy. When received, the to her illness; returning home two months before its onset. She has lived the greater part of her life in Wagga and the surrounding district. On her return to Tumbarumba two months before her illness she and her husband became on friendly terms with carpenter and his wife working on railway construction and these two constantly came to her house. Both the car- penter and his wife had been infected with and suffered from malaria in "The Islands." During the two months the car- penter's wife suffered from a recurrence of her malaria and was ill for some days. Alongside the residence of the patient whose case is being reported, is, she states, some swampy ground and mosquitoes are very numerous. Six weeks ago the patient suddenly became ill with "fever," rigors and persistent vomiting. There was no headache, no cough, no epistaxis and no diarrhoea (until two weeks after onset, when there occurred some slight diarrhoea lasting about a week). Occasional pain was felt, not severe, in the left hypochondrium. There were no urinary symptoms and no hm:naturia. The condition continued for some days, with irregular fever, rigors and persistent vomiting, when she was sent to a hospital in Wagga. In spite of treatment on general lines, the condition did not abate; rigors occurred as shown in the chart, as well as vomiting and pain in the left hypochondrium. The spleen was noticed to be enlarged and the patient had an enlarged thyreoid gland. FIGURE III.. 'After some ten days in hospital the symptoms subsided, Decidual Cast from Uterus Containing Human Ovum (H y ) in Which no Embryo was to be Found. the enlargement of the spleen disappeared and the patient rapidly improved. She was convalescent and was about to get up on the next day, when the condition recurred, with specimen consisted of a decidual cast containing a all the previous symptoms. After a couplé of days there chorionic vesicle in situ (Figure III.) . The decidua occurred sudden enlargement of the spleen, which could be capsularis had been reflected and the villi were vis- felt about 2.5 cm. below the costal margin. • ible. On clearing this specimen in cedar oil, no em- One week after the recurrence she was sent to Sydney for further investigation. bryo was discoverable and a microscopic examina- The case, so far, clinically fitteiYÏn with malaria and this tion confirmed the absence of embryonic structures. diagnosis had suggested itself to Dr. Weedon, who, in his notes, forwarded at the time, states "has lived in Wagga References. all her life. No malaria here, except returned soldiers." The (1) Cameron, S. J.: "Twin Tubal Pregnancy," Proc. Roy. diagnosis would, in the ordinary course of events, be natu- Soc. Med., Vol. 4, Pt. 2, 1910-11. rally excluded on geographical grounds. (2) Child, C. G.: "Twin Ectopic Pregnancy," Amer. Journ. On examination on her arrival in Sydney, the patient's Obstetrics, January, 1907. condition was very alarming. (3) Williams, Whitridge: "Obstetrics" (text-book), 1917. Her temperature was 36.6 ° C.; pulse-rate 156, small volume (4) Fransden: Quoted by Chiene, Obstet, Trans., Edin., and very feeble, of low tension; respirations 24. She looked 1913, 38. desperately ill and was in the "typhoid state." Her face -_.—_-- -^
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^ a3 sz ^ m H ^.^ q ^ ° 9 + Cz ^^ ^ ^ A a^ ^ ^a 4 ii■I[ III./iiiiiiii 01 ^^ ^^^, ^ ^^^^^^ ^ Cg a^ cd wa^ q^ ^^m^R O O cd z4v 1111111•111111111111111M1 O O ■Ci3IIDL■1I I11111111■1 ^^ ^^ ° ó ^ 3,xt ^ *'^ sR I ■ ?)..E,90. a ° ■■■I^It `iü=^!^ III1i 1 I R, ° i s°. ° t ^ cd ^ m —C a° ■■1111^ I1I °v ^^ on ^ ^ 3 ^ ^^ ^ •^ ^^ w Hp° pLa,-.^ ° >° ^^° o c m ìlllllll lll Ilü^i^^.^. d id. E ^;^ ^.^ a, o l v +,". Etìii111^C1'L^1'^11111/^ m a) âi c°d E ^ D m+'H c, ai• ^ a>+-' ^W _1^^v^ c a^ °H âz Ó 0. Ii+CI WilizsgCInamoiúlllCa1 ^ HH c^d+^ m éi  v;ÓH ß, ?^ ^ o g 4T 384 THE MEDICAL JOURNAL OF AUSTRALIA. [May 7, 1921. hospital in Sydney that she was immediately given intra- in that district. The position seems to us to be most serious, venous injections of bicarbonate of soda in saline solution, to demand an immediate mosquito survey first of all in this stimulant treatment, morphine hypodermically and feeding district and later throughout other areas with the object of per rectum. Her condition was so bad that, in spite of the dealing scientifically with the mosquito and its breeding . persistent vomiting, washing out the stomach could not be places. The situation also demands immediate search for considered on account of the distress it would cause. and thorough treatment of all cases of malaria in Australia. The following day her general condition was slightly im- We hasten to report this case hoping that early steps may proved. though she was still alarmingly ill. The treatment prevent the spread of this danger to the community. was repeated. Acetone disappeared from the urine and she It is probable in these post-war days that there are and improved perceptibly. have been other cases of unexplained irregular fever, diag- Having in view the fact that the ordinary causes of nozed provisionally perhaps as enteric fever, influenza, etc., toxæmia had been clinically excluded. the cause of the con- in which the malarial parasite has been at work unrecog- dition was pathologically investigated. Blood examinations nized. We ourselves have at present under observation an were made to exclude pernicious anæmia, typhoid and para- obscure case of irregular fever which was under the care of typhoid fevers and malaria Subacute yellow atrophy of the one of us some time ago. liver was also considered a possible diagnosis (though no This patient presented most perplexing symptoms and convulsions and no jaundice had occurred) and the urine was seen in consultation by many other medical men. Un- was examined for leucin and tyrosin, which were absent. fortunately during the pyrexia no investigation with the No Widal reaction was obtained with Bacillus typhosus or specific object of discovering malarial parasites was sug- Bacilli paratyphosus A and B. gested, that provisional diagnosis having very naturally been A blood count showed: excluded on account of her residence in the western district Total Red Cells .. 4,200,000 per c.mm. of New South Wales and of the fact that she had not been Hemoglobin 60 farther north than Sydney. Colour Index .. .. 0.7 In view of the findings in the case now reported, we are Total Leucocytes 6,300 per c.mm. again in touch with this patient. On reviewing her case, it Differential count: seems that the clinical history and features correspond re- Polymorpho-nuclear cells . .. 68 markably with malaria. The disease, if present, is however Lymphocytes .. . 30% now quiescent, but a prolonged search or a recurrent attack Monocytes . .. 2% may reward us in finding the parasite. Another impressive feature about this case is the fact No eosinophile cells were seen. The red cells were practically that in the stage of fever when there was a leucopenia normal in size and shape. (again fitting in with malaria) and relatively slow pulse, Malarial parasites were present in large numbers, includ- a provisional diagnosis of enteric fever was made and the ing trophozoites, macrogametocytes and microgametocytes of patient was given, as she was constipated, a daily enema of the tertian type. No crescents were seen. sulphate of quinine. On defervescence her anmic con- The case was, undoubtedly, on the pathological findings, dition was treated with arsenic. The "accidental" adminis- one of malaria. tration of quinine and arsenic may have had some influence With the discovery of the parasite and in view of the should the case have been one of malaria. clinical history and signs, the diagnosis of tertian malaria Should the investigation reveal a malarial infection, the was obvious. case will be reported later. On the day while waiting for the pathological report, the This article may draw attention to the necessity of in- patient complained of pain in the left hypochondrium and cluding malaria in the provisional diagnosis of any case of the spleen, which in the two days she had been under obser- irregular fever, in addition to urging the adoption of vation had not been palpable, was found to be distinctly measures necessary for the preservation of the public health. enlarged to 2.5 cm. below the costal margin. This enlarge- We again beg to acknowledge our indebtedness to Dr. ment is now subsiding. Weedon, of Wagga, and to Dr. Frank Tidswell for his With appropriate specific treatment the patient is rapidly interest in the pathological work and for information from improving. There is no vomiting; the pulse is almost normal. his own practical experience of the previous history of
• The cardiac oondition has improved. The liver dulness, malaria in Australia. diminution of which was probably due to hyperemesis, caus- ing a temporary atrophy of glycogenic cells, is now in- . Addendum. creasing towards normal. The patient's general condition Since the foregoing article was written we have investi- is good and she is well on the way to recovery. gated another case from Barraba near Tamworth, New The only difficulty in treatment lay in the grave hyper- South Wales, in which we have established the 1iagnosis of emesis; but quinine was given at first intravenously and by aboriginal malarial infection by the discovery of the parasite. the high rectal method. Now that the vomiting has subsided, In addition the "obscure" case mentioned in the article quinine is being given by the mouth and novarsenobillon has, on repeated examinations, revealed intra-corpuscular intramuscularly. The intravenous injections of bicarbonate chromatin bodies in great numbers. Though no typical of soda in saline solution and of quinine have now rendered parasites have been found, these bodies are so numerous as the veins useless. They were originally "poor ones" and definitely to indicate that they are degenerated forms of the were made more so by her condition. amoeba; this degeneration had no doubt occurred in conse- quence of the patient now being convalescent and in conse- Comment. quence of the small doses of quinine and arsenic which We consider that the discovery of this case is of the she has received. Taking these findings together with the utmost importance to the public health. It has been recog- clinical history and signs, we do not hesitate to make a nized that the return of great numbers of men suffering final diagnosis of malaria. from malaria from Palestine and New Guinea after active This case is also an indigenous infection, the patient service would provide a source of spread of this disease in coming from Forbes, New South Wales. Australia. Anophelines are authoritatively stated to exist These three cases (from the Riverina, from the western throughout Australia. We now have a case, the first we district and from New England) emphasize the fact that believe to have been actually reported south of Sydney, the disease has certainly gained a foothold in widely where aboriginal infection has occurred, where a patient scattered centres in New South Wales. as a source of infection 'is * known definitely to have been present within "mosquito distance" of the patient infected, where the essential condition (swampy ground) for the Corrigendum. breeding of mosquitoes has also been present within mos- Our attention has been directed to an error in an an- quito distance of both the "carrier" and the new host, nouncement made in our issue of April 16, 1921 (page 314). where we can exclude previous infection from other known Dr. E. W. Chenoweth has been appointed Stewart Lecturer malarial districts and where the actual parasite has been in Anatomy at the Melbourne University. The Stewart Lec- found in the blood of the infected patient. The whole chain turer in Medicine to succeed Sir Henry Maudsley has not is complete except the actual discovery of infected mosquito yet been appointed. May 7, 1921.] THE MEDICAL JOURNAL OF AUSTRALIA. 385
host of the plasmodium. It is assumed, but not proven, that the sub-family Anophelinco alone can transit the Che medical Journal of 3iustralía. disease. In science guesses are inadmissible. It is essential that someone should determine the actual
SATURDAY, MAY 7, 1921. mosquito which transmits the parasite in those dis- tricts of Australia where malaria is prevalent. Che malaria Danger. Mr. Taylor found Nyssorhynchus annulipes in prac- tically every district investigated from Pompoota, a On January 5, 1915, a patient was admitted to the township not far from the mouth of the Murray River, Sydney Hospital under the charge of Dr. Sydney to Kyabram. In the eastern areas there were many Jamieson suffering from malaria. This man had not varieties of mosquitoes, including Anophel nce and been outside the State of New South Wales for a Culicinw. The survey was not extended to the north period of 21 years and for five years he had not left into the Murrumbidgee irrigation area, nor eastward the Gosford district. He had not previously been up to the Snowy Mountains. The information, how- affected with the disease. It thus appears that the ever, contained in his report was most disquieting. infection had taken place locally, probably from some- In some places, there was already a large anopheline one who had returned from New Guinea. The case mosquito population. Apparently but small meteoro- was published in our issue of February 20, 1915, and logical changes and an extension of settlement would at the same time we issued a grave warning to those suffice to render the main water street of three Aus- responsible for the safety of the public. At that tralian States a hot bed of anophelines and thus time it was held by many that the anopheline mosquito presumably a potential source of danger to the population south of the northern portion of Queens- community. land was so small that there was no real danger of a A year later, that is in 1918, Dr. Breini and Mr. spread of malaria. A year later a conference took Taylor published in this journal a report of the sur- place between the military medical authorities, the vey undertaken in Cairns. This report is important Director of Quarantine and others concerned with the in view of the fact that in the definitely infected area malaria problem. As a result of this conference a two anopheline mosquitoes were found in consider- definite course of action was adopted, aiming at the able numbers. They are Nyssorhynchus annulipes control of persons returning from. New Guinea in- and Myzorhynchus bancro f ti. Culicine mosquitoes fected with malaria. It was decided to place these were also abundant. persons under observation and treatment. Further it In the present issue Dr. II. J. Clayton gives a full was determined to segregate all invalided and dis- account of a malarial infection of a person who had charged soldiers then in the Commonwealth, who were not been outside the district of Wagga Wagga. The known to have been infected with malaria. In 1917, chain of evidence is complete, proving that the in- Mr. F. H. Taylor, F.E.S., Entomologist at the Aus- fection was a local one, notwithstanding the fact that tralian Institute of Tropical Medicine, published the the mosquito conveying it was not identified. Dr. results of a malaria mosquito survey of the irrigation Clayton also refers to two other cases in which a local areas in the Murray River district. In order to make infection has occurred. In next week's issue we hope the position amply clear, it must be stated in this to publish a short account by Dr. Gerald Doyle of place—we have called attention to the fact many times another instance of local infection in St. Arnaud, in the past—that we are ignorant concerning the mos- Victoria. The inference that Dr. Jamieson's case, quito vector of the Plasmodium malarice in Australia. Dr. Clayton's three cases and Dr. Doyle's case do not It has been inferred that here as elsewhere the ano- represent the only indigenous infections will scarcely pheline Nyssorhynchus annulipes is the mosquito that be challenged. How many malarial infections have conveys malaria from patient to patient. In other been mistaken from influenza, rheumatic attacks or countries it has been found that not every anopheline other common illnesses, no one can say. It is probable mosquito is capable of acting as the intermediary that malaria has already gaindd a sufficiently firm 386 THE MEDICAL JOURNAL OF AUSTRALIA. [May 7, 1921.
hold in New South Wales—and possibly other States— hold the infection within narrow limits. In these to constitute an immediate, and serious menace to the circumstances we regard the painstaking and exten- sive study undertaken by Dr. J. P. Greenberg at the community. Very active steps are needed to check Gynecological Clinic of the Johns Hopkins Hospi- its spread. Malaria, like yellow fever, can be stamped tal of a large number of cases of tubercular salpin- • out of any community. The cost is relatively small, gitis as an important and helpful work.' It appears that during the thirty years up to the end of 1919, if the attack be planned and carried out before the tuberculous changes were detected under the micro- intermediary hosts have established themselves in scope in the Fallopian tubes of 200 patients, while there were reasonable grounds for the assumption that the overwhelming numbers and over a large area. It must tubes were involved in a tubercular infection of the be remembered that the price of irrigation includes peritoneum in at least 23 other patients. The 200 the risk of a spread of the mosquito population. If Patients represented 0.83% of all the patients treated for gynecological disorders in the clinic during this we had a map of the Commonwealth, marked with period. Moreover, Dr. Greenberg finds that of every the varieties of mosquitoes in each and every district, 13 tubes removed, one was affected with tuberculosis. While the majority of the patients were of the child- we would be able to gauge the magnitude of the bea ring age, the affection was seen in young girls from task of removing the malaria danger from our midst. the age of 14 years and in women up to the age of 55 years. Approximately 60% of the patients were sterile. The symptoms included pain in the lower TUBERCULOSIS OF THE FALLOPIAN TUBES. segment of the abdomen and in the back, menstrual disturbances (dysmenorrhoea, tmenorrhagia, oligo- There are many pathological processes the signifi- menornccra; and amenorrhoea) and leucorrhoea. It is cance of which is not fully recognized as a result of pointed out that pain in the neighbourhood of the clinical observation. History reveals that these pro- umbilicus, supposed to be characteristic in tubercular cesses have been regarded as rare occurrences until peritonitis, was complained of by Duly 14 patients, an astute investigator has delved deeply into the notwithstanding the fact that no less than 126 of the pathology and has correlated the clinical manifesta- patients had in addition to a tubercular disease of tions with the pathological changes. The attention the tubes a tubercular peritonitis. A definite onset of the profession has then been turned to the condi- was timed on 74 occasions. Fever was considerably tion and it has been found that a supposedly uncom- more common in the patients with peritoneal involve- mon affection has passed undiscovered in every clinic ment. About 25% of the patients had at the same and in every extensive private practice. It appears time a pulmonary tuberculosis. that such a course of events occurred in the case of The data given above reveal that tubercular salpin- tubercular salpingitis. Before 1886, the disease was gitis is by no means a characteristic condition. It is overlooked save when the process had developed to therefore not surprising to learn that a correct pre- so advanced a stage and the changes had become so operative diagnosis was made in only 26 instances, typical that the diagnosis was self-evident. Hegar i.e., in 13%. In this connexion it would seem that was the first to dispute the firmly-rooted belief that the cases dealt with in the Gynæcological Clinic at the this affection was very rare. He showed that in the Johns Hopkins Hospital were sufficiently advanced majority of instances it either passed unnoticed or to demand operative interference. No information was mistaken for other affections of the Fallopian is offered concerning tubercular lesions of the tubes tubes because there were no special or specific char- without extensive implication of adjacent or distant acters that could be discerned by clinical examination tissues or organs. There is some evidence in support or by macroscopic inspection. Even to-day the major- of the contention that a localized tuberculosis of the ity of general practitioners are forced to the conclu- pelvic organs is not rare. Dr. Greenberg's figures sion that tuberculosis of the tubes needs scarcely be are suggestive, for in 43% of the cases either the considered in the differential diagnosis of pelvic dis- tubes alone or the tubes and the pelvic peritoneum orders. Unfortunately this affection is not unique in were involved without any other pelvic lesion. Efforts resisting an accurate diagnosis without the micro- should be made to improve our diagnosis, so that scope. Moreover, it is extremely difficult to form a some, at all events, of the less severe cases might be correct conception of the pathological value of tuber- recognized. The diagnostic failure in 87% of marked cular disease. The diagnosis of tuberculosis based on cases is not creditable to scientific gynecology. That biological reactions is not reliable, since healed or this matter is important in the interests of the pa- latent lesions may be accompanied by antibodies tients, is revealed by the record of the. results. There
' capable of yielding specific reactions. The differentia- were 17 deaths in the hospital among the 200 pa- tion between clinical tuberculosis which endangers tents. Of these 17, seven patients had definite pul- the life of the patient and a tubercular infection monary tuberculosis. While Dr. Greenberg was un- with which the body is capable of dealing, is fraught able to discover the fate of all the 183 patients dis- with difficulty and traps for the unwary. In addi- charged from the clinic, he was able to ascertain that tion it has to be recognized that when the disease is nine out of 90 had died of their tuberculous infec- localized in a special organ or tissue, the clinical tion. We may assume that the tubercular disease • significance to the patient will depend to a consider- robbed at least 26 patients of their lives. It is un- able extent on the power of the organ or tissue to ' .Bulletin of the John8 Horokina.HOapital, February. 1921.