Clemson University TigerPrints All Dissertations Dissertations 8-2013 A NOVEL GAIN OF FUNCTION OF THE IRX1 AND IRX2 GENES DISRUPTS AXIS ELONGATION IN THE ARAUCANA RUMPLESS CHICKEN Nowlan Freese Clemson University,
[email protected] Follow this and additional works at: https://tigerprints.clemson.edu/all_dissertations Part of the Developmental Biology Commons Recommended Citation Freese, Nowlan, "A NOVEL GAIN OF FUNCTION OF THE IRX1 AND IRX2 GENES DISRUPTS AXIS ELONGATION IN THE ARAUCANA RUMPLESS CHICKEN" (2013). All Dissertations. 1198. https://tigerprints.clemson.edu/all_dissertations/1198 This Dissertation is brought to you for free and open access by the Dissertations at TigerPrints. It has been accepted for inclusion in All Dissertations by an authorized administrator of TigerPrints. For more information, please contact
[email protected]. A NOVEL GAIN OF FUNCTION OF THE IRX1 AND IRX2 GENES DISRUPTS AXIS ELONGATION IN THE ARAUCANA RUMPLESS CHICKEN A Thesis Presented to the Graduate School of Clemson University In Partial Fulfillment of the Requirements for the Degree Doctor of Philosophy Biological Sciences by Nowlan Hale Freese August 2013 Accepted by: Dr. Susan C. Chapman, Committee Chair Dr. Lesly A. Temesvari Dr. Matthew W. Turnbull Dr. Leigh Anne Clark Dr. Lisa J. Bain ABSTRACT Caudal dysplasia describes a range of developmental disorders that affect normal development of the lumbar spinal column, sacrum and pelvis. An important goal of the congenital malformation field is to identify the genetic mechanisms leading to caudal deformities. To identify the genetic cause(s) and subsequent molecular mechanisms I turned to an animal model, the rumpless Araucana chicken breed. Araucana fail to form vertebrae beyond the level of the hips.