Ethnopharmacology, Chemodiversity, and Bioactivity of Cephalotaxus Medicinal Plants
Available online at www.sciencedirect.com Chinese Journal of Natural Medicines 2021, 19(5): 321-338 doi: 10.1016/S1875-5364(21)60032-8 •Review• Ethnopharmacology, chemodiversity, and bioactivity of Cephalotaxus medicinal plants HAO Da-Cheng1*, HOU Xu-Dong2, GU Xiao-Jie1, XIAO Pei-Gen3, GE Guang-Bo2* 1 Biotechnology Institute, School of Environment and Chemical Engineering, Dalian Jiaotong University, Dalian 116028, China; 2 Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 3 Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100193, China Available online 20 May, 2021 [ABSTRACT] Cephalotaxus is the only genus of Cephalotaxaceae family, and its natural resources are declining due to habitat frag- mentation, excessive exploitation and destruction. In many areas of China, folk herbal doctors traditionally use Cephalotaxus plants to treat innominate swollen poison, many of which are cancer. Not only among Han people, but also among minority ethnic groups, Cephalotaxus is used to treat various diseases, e.g., cough, internal bleeding and cancer in Miao medicine, bruises, rheumatism and pain in Yao medicine, and ascariasis, hookworm disease, scrofula in She medicine, etc. Medicinal values of some Cephalotaxus spe- cies and compounds are acknowledged officially. However, there is a lack of comprehensive review summarizing the ethnomedicinal knowledge of Cephalotaxus, relevant medicinal phytometabolites and their bioactivities. The research progresses in ethnopharmaco- logy, chemodiversity, and bioactivities of Cephalotaxus medicinal plants are reviewed and commented here. Knowledge gaps are pin- pointed and future research directions are suggested. Classic medicinal books, folk medicine books, herbal manuals and ethnomedicin- al publications were reviewed for the genus Cephalotaxus (Sanjianshan in Chinese).
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