Rectal Water Contrast Transvaginal Ultrasound Versus Double-Contrast Barium Enema in the Diagnosis of Bowel Endometriosis
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Open Access Research BMJ Open: first published as 10.1136/bmjopen-2017-017216 on 7 September 2017. Downloaded from Rectal water contrast transvaginal ultrasound versus double-contrast barium enema in the diagnosis of bowel endometriosis Jipeng Jiang, Ying Liu, Kun Wang, Xixiang Wu, Ying Tang To cite: Jiang J, Liu Y, Wang K, ABSTRACT Strengths and limitations of this study et al. Rectal water contrast Objectives The aim of study was to compare the transvaginal ultrasound versus accuracy between rectal water contrast transvaginal ► This is the first comparison of the accuracy between double-contrast barium enema ultrasound (RWC-TVS) and double-contrast barium enema in the diagnosis of bowel rectal water contrast transvaginal ultrasound (RWC- (DCBE) in evaluating the bowel endometriosis presence as endometriosis. BMJ Open TVS) and double-contrast barium enema (DCBE) in well as its extent. 2017;7:e017216. doi:10.1136/ the diagnosis of bowel endometriosis. Design and setting 198 patients at reproductive age with bmjopen-2017-017216 ► This study demonstrated RWC-TVS as a very reliable suspicious bowel endometriosis were included. Physicians technique to determine the bowel endometriosis ► Prepublication history for in two groups specialised at endometriosis performed presence and extent and it has similar accuracy to this paper is available online. RWC-TVS as well as DCBE before laparoscopy and both To view these files please visit that of DCBE. groups were blinded to other groups’ results. Findings the journal online (http:// dx. doi. ► We demonstrate that DCBE is related to more from RWC-TVS or DCBE were compared with histological org/ 10. 1136/ bmjopen- 2017- tolerance than RWC-TVS. results. The severity of experienced pain severity through 017216). ► This study requires a larger sample once suitable RWC-TVS or DCBE was assessed by an analogue scale of participants become available. Received 7 April 2017 10 cm. Revised 26 May 2017 Results In total, 110 in 198 women were confirmed to Accepted 12 June 2017 have endometriosis nodules in the bowel by laparoscopy as well as histopathology. For bowel endometriosis suggest rectovaginal endometriosis presence. diagnosis, DCBE and RWC-TVS demonstrated sensitivities However, the accuracy is poor in identifying of 96.4% and 88.2%, specificities of 100% and 97.3%, 5 6 rectosigmoid nodules. http://bmjopen.bmj.com/ positive prediction values of 100% and 98.0%, negative Until recently, endometriosis diagnosis prediction values of 98.0% and 88.0%, accuracies of ultrasound was limited to patients with ovarian 98.0% and 92.4%, respectively. DCBE was related to more tolerance than RWC-TVS. endometriosis. Other imaging methods were Conclusions RWC-TVS and DCBE demonstrated similar used for assessing bowel endometriosis, such accuracies in the bowel endometriosis diagnosis; however, as rectal endoscopic ultrasound, double-con- patients showed more tolerance for RWC-TVS than those trast barium enema (DCBE), transvaginal with DCBE. ultrasound (TVS), MRI, virtual colonoscopy 7–10 and multidetector CT enema (MDCT-e). on September 23, 2021 by guest. Protected copyright. TVS, as a reliable and non-invasive method INTRODUCTION for assessing bowel endometriosis presence Bowel endometriosis influences 4%–37% and extent.11 Rectosigmoid nodules identifi- patients of endometriosis.1 Lesions in intes- cation may be facilitated by saline injection tinal endometriosis have variable sizes.2 through a catheter going into the rectum Endometriosis nodules of small sizes locate through rectal water contrast TVS (RWC- in the bowel serosal surface hardly causing TVS), assessment of infiltration depth of symptoms and treatments are not required.2 endometriosis on intestinal wall as well as Endometriosis nodules of larger sizes may estimation of stenosis degree in the bowel infiltrate the wall of bowel and cause some lumen. Yet, no studies have compared the gastrointestinal complaints such as diarrhoea, accurateness between DCBE and RWC-TVS 4 12 13 Department of Ultrasound, dyschezia, constipation, intestinal cramping in rectosigmoid endometriosis diagnosis. Tianjin First Center Hospital, and abdominal bloating.1 3 The symptoms The diagnosis of bowel endometriosis Tianjin, China mimic acute bowel syndrome. The symp- presence and extent before the surgery is Correspondence to toms with bowel endometriosis mainly are necessary for making a decision on whether Dr Ying Tang; non-specific, usually causing misdiagnosis or the operation is required as well as planning dr_ tangying@ sina. com diagnosis delay.4 Physical examinations may the operation procedure with colorectal Jiang J, et al. BMJ Open 2017;7:e017216. doi:10.1136/bmjopen-2017-017216 1 Open Access BMJ Open: first published as 10.1136/bmjopen-2017-017216 on 7 September 2017. Downloaded from surgeons.14 Preoperational knowledge of intestinal endo- others. They were also blinded to clinical data and only metriosis nodules size, number, nodule infiltration depth knew that the intestinal endometriosis presence was on the wall of intestine, as well as bowel lumen stenosis suspected. All the patients underwent laparoscopy, which degree allows for making best decision on whether the was within 1 month after completion of investigations for surgery is requisite and whether nodulectomy or bowel diagnosis. Intestinal endometriosis disease was defined by segmental resection should be chosen.15 16 the minimum infiltration of muscularis propria. Endo- Additionally, preoperational determining of bowel metriosis foci on bowel serosa were peritoneal instead of endometriosis extent allows for that the surgeon informs bowel endometriosis. This study investigated the accu- the patient of the benefits as well as potential complica- rateness of RWC-TVS and DCBE in assessing the bowel tions during the operation procedure to be performed. endometriosis presence, evaluating the number and the In fact, evolution or complications of the symptoms in size for nodules of bowel endometriosis as well as deter- digestive system postsurgery may be different for patients mining the existence of peritoneal endometriosis with experiencing nodulectomy and segmental resection. In only intestinal serosa being infiltrated. this study, we assessed and compared the diagnosis accu- racy between DCBE and RWC-TVS for evaluating the Technique of rectal water contrast transvaginal ultrasound bowel endometriosis presence and extent. Two physicians conducted all of the examinations in line with a standardised procedure.10 RWC-TVS was conducted by using a Voluson E6 machine connected MATERIALS AND METHODS with a transvaginal transducer. Once the transducer was Study population placed in the vagina, a 6 mm flexible catheter was inserted This study was conducted from May 2012 to Aug 2016. in rectal lumen with a distance of 15 cm to the anus Patients at the reproductive ages with laparoscopy sched- through the anus. To facilitate of the catheter passage, uled for intestinal endometriosis suspicious clinical exam- a gel containing lidocaine was applied. A 50 mL syringe ination or symptoms were recruited as participants in this connected with the catheter and warm saline solution study. During this period, it is required by imaging workup then was injected to the rectum as well as the sigmoid that DCBE and RWC-TVS were conducted in the patients with ultrasonic control. The saline solution amount for with suspicious bowel endometriosis. Institutional Review showing the rectosigmoid varied from 100 to 350 mL, Board of Tianjin First Center Hospital approved the based on the intestinal wall dispensability. One hundred protocols involved in this study before initialisation of millilitres saline solution was slowly and continuously the study. All patients enrolled in this study signed the instilled at the procedure beginning, and the rest solu- written consent form. Inclusion criteria of this study were: tion was instilled if requested by ultrasound. When the suspicious deep pelvic endometriosis, at reproductive saline solution was not being infused during the ultra- age, gastrointestinal symptoms likely being caused by the sound, Klemmer forceps attached to the catheter was http://bmjopen.bmj.com/ bowel endometriosis, desire for complete surgical endo- placed to prevent backflow in the catheter. No significant metriosis excision. Exclusion criteria of this study were: saline solution leakage in the space was seen between precedent bilateral ovariectomy, radiological diagnosis of catheter and anus. Before, during as well as after saline bowel endometriosis, examination of barium radiology, injection, images were taken. Bowel endometriosis was colorectal surgery, hepatic or renal failure, suggestive shown ultrasonographically as solid, hypoechoic, nodular intolerance for iodinated contrast medium or refuse for lesions, adjacent to or penetrating the wall of the intes- DCBE or psychiatric disorders. tine. Hyperechoic foci sometimes may present inside the Symptoms were investigated systematically throughout lesion. Intestinal distension permits defining the intes- on September 23, 2021 by guest. Protected copyright. the study and were documented in a database. The exis- tinal nodule limits and various layers within rectal wall in tence of deep dyspareunia, dysmenorrhoea, dyschezia particular so as to estimate infiltration depth. The submu- and non-menstrual pelvic was examined and the symptom cosa and intestinal serosa are hyperechoic. Two layers in intensities were evaluated of all patients by a 10 cm visual muscularis propria