Emtree Terms Added and Changed (May 2015) This is an overview of new terms added and changes made in the second Emtree release in 2015. Overall, Emtree has grown by 848 preferred terms (124 drug terms and 724 non-drug terms) compared with the previous version released in January 2015. In total Emtree now counts 71,802 preferred terms. Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept. The terms added and changed are summarized below and specified in detail on the following pages. Emtree Terms Added in May 2015 1037 new terms (including 225 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version May 2015 (compared to January 2015): 172 drug terms (terms assigned to the Chemicals and Drugs facet). 901 non-drug terms (terms not assigned as Chemicals and Drugs). The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2015 (typically as candidate terms), sometimes for several years, before they were added to Emtree. Emtree Terms Changed in May 2015 225 terms (48 drug terms and 177 non-drug terms) from Emtree January 2015 have been replaced by 220 different terms in May 2015 (48 drug terms and 172 non-drug terms). Of these, 144 terms (17 drug terms and 127 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2015; the remaining 76 replacement terms (31 drug terms and 45 non-drug terms) were already present in Emtree. No drug terms were replaced by a non-drug term, no non-drug terms were replaced by a drug term. No preferred terms were deleted. Changes are presented in alphabetical order of the new terms. Emtree Terms Added in May 2015 2 Drug terms 1 (6 benzothiazolylsulfonyl) 5 chloro 1h indole 2 amlodipine plus perindopril butanoic acid antazoline plus tetryzoline 1 [2 (benzo[1,2,5]thiadiazol 5 ylamino) 6 (2,6 ascrinvacumab dichlorophenyl)pyrido[2,3 d]pyrimidin 7 yl] 3 asinercept tert butylurea Astragalus root 1 amino 4 (2 asunaprevir plus beclabuvir plus daclatasvir phenylcyclopropylamino)cyclohexane atezolizumab 1,2,3,5 tetrahydro 1 (2 isopropoxyethyl) 2 avacincaptad pegol thioxopyrrolo[3,2 d]pyrimidin 4 one avi 7537 14 o [(1 valyl 3 piperidinylthio)acetyl]mutilin avoralstat 14 o [(3 hydroxymethylphenylthio)acetyl]mutilin axalimogene filolisbac 2 (4 cyclopentylaminophenyl) 1 (2 fluoro 6 bacmid methylbenzoyl) 3 piperidinecarboxylic acid (4 balixafortide methyl 3 trifluoromethylphenyl)amide beta intermedin derivative 2 [4 [3 (4 bromophenyl)acrylamido] 3 bexaglifozin fluorophenyl] 5 benzoxazoleacetic acid bis(8 hydroxy 5 quinolinyl)[4 2 [[3 [4 [3 (diisobutylamino)propyl] 1 (trifluoromethyl)benzyl]amine piperazinyl]propyl]amino] 1h benzimidazole bismuth 207 2 hydroxy 3 (2 thienylacetamido) 1,5,2 bms 824393 dioxaborepane 7 acetic acid bovhyaluronidase azoximer 2 hydroxymethyl 2 methoxymethyl 3 Bovine viral diarrhea virus vaccine quinuclidinone brain natriuretic peptide derivative 2,2 dimethylbutyric acid brolucizumab 3 (2,3 dihydroxypropyl) 6 fluoro 5 (2 fluoro 4 calcium carbonate plus colecalciferol plus iodoanilino) 8 methylpyrido[2,3 d]pyrimidine ibandronic acid 4,7 dione calcium carbonate plus colecalciferol plus 4 [[5 [4 [4 (2 oxazolyl)phenoxy]benzyl] 2,5 zoledronic acid diazabicyclo[2.2.1]hept 2 yl]methyl]benzoic cinhyaluronic acid acid cinnarizine plus domperidone 4 amino n (3 chloro 4 fluorophenyl) n' hydroxy ciraparantag 1,2,5 oxadiazole 3 carboximidamide crisaborole 4' chloro 4 hydroxy 3 methoxychalcone dapagliflozin plus saxagliptin 5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 daprodustat yl) 2 pyrimidinamine dasabuvir plus ombitasvir plus paritaprevir plus 5 bromo n (2 propynyl) 2 (1h 1,2,4 triazol 1 yl) 4,6 ritonavir pyrimidinediamine decitabine 5,10,15,20 tetrakis(2,6 difluoro 3 n dectrekumab methylsulfamoylphenyl)bacteriochlorin derlotuximab biotin i 131 6 amino 5 [1 (2,6 dichloro 3 fluorophenyl)ethoxy] desfesoterodine n [4 (4 methyl 1 piperazinylcarbonyl)phenyl] 3 deutetrabenazine pyridazinecarboxamide dinotefuran plus pyriproxyfen 6 ethoxy 7 methoxy 2 (2 methylthiophenyl) 3,1 dusquetide benzoxazin 4 one edotreotide ga 68 [4 [(5,6 diphenyl 2 elafibranor pyrazinyl)(isopropyl)amino]butoxy]acetic acid elbasvir plus grazoprevir ach 2928 eleclazine afoxolaner plus milbemycin oxime elgemtumab aglatimagene besadenovec eltrapuldencel T akb 6548 emeramide altiratinib empagliflozin plus linagliptin amg 157 enoblituzumab amifampridine epacadostat amiselimod epetraborole amitriptyline plus chlordiazepoxide eprociclovir Emtree Terms Added in May 2015 3 erlosiban netarsudil etelcalcetide nonstructural protein 5A inhibitor fampridine olifilcon A gamma intermedin derivative olifilcon B gepotidacin olifilcon C gsk 2336805 olifilcon D guadecitabine ombitasvir plus paritaprevir plus ritonavir helper dependent adenoviral vector opicinumab hepacivirin ozanimod hepacivirin inhibitor pexidartinib heparanase inhibitor phoxilium ibiglustat pinometostat idx 320 pleuromutilin antibiotic agent immucillin A pleuromutilin derivative immucillin A triphosphate ppi 461 indimilast pterostilbene indoxacarb plus permethrin radalbuvir indusatumab ravidasvir indusatumab vedotin refanezumab infigratinib relaxin derivative irisin ridinilazole isatuximab rinucumab isunakinra rod derived cone viability factor ivacaftor plus lumacaftor roneparstat labetuzumab govitecan sacubitril plus valsartan lascufloxacin sapanisertib lavamilast seletalisib lilotomab somapacitan lilotomab satetraxetan lutetium lu 177 somavaratan lipotropin derivative spanlecortemlocel lokivetmab sparsentan lopixibat chloride stapuldencel T mereletinib streptocin merestinib tafluprost plus timolol milbemycin oxime tazemetostat motilin derivative teixobactin mycophenolate mofetil tesevatinib n (3 pyridazinyl) 4 [3 (5 trifluoromethyl 2 tesidolumab pyridinyloxy)benzylidene] 1 thymopoietin derivative piperidinecarboxamide thymosin derivative n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 thyrotropin derivative methylpropoxy) 4 pyrimidinyl] 1 tiamulin fumarate azetidinesulfonamide tkm 100802 n [4 [2 [(4 morpholinophenyl)amino] 4 trofinetide pyrimidinyl]phenyl] 2 pyrrolidinecarboxamide vandortuzumab vedotin natriuretic peptide type C derivative vosoritide neladenoson delanate ZMapp nelonicline nemolizumab Emtree Terms Added in May 2015 4 Non-drug terms 47,XXX syndrome Antilopinae 47,XXY syndrome aorta endothelium 47,XYY syndrome Aparavirus 48,XXXX syndrome APD50 48,XXXY syndrome APD90 49,XXXXX syndrome Apophysomyces 49,XXXXY syndrome apparent dissociation constant 5-oxoprolinuria apparent permeability Abelson murine leukemia virus Apple scar skin viroid absorption rate constant Apscaviroid accumulation ratio Arabian horse Achatina architect Acinetobacter anitratus Arctocephalus Acinetobacter calcoaceticus-baumannii complex Arctocephalus gazella Actinoplanes Arctocephalus pusillus action potential amplitude area under the curve ratio activation constant area under the moment curve activation time constant Arteriviridae Acute bee paralysis virus association constant acute hepatitis A association rate constant acute hepatitis B Astragalus (plant) acute hepatitis C Astroviridae acute inflammatory demyelinating Atelinae polyneuropathy atrial fibrillation adenosine-induced hyperemia atypical teratoid rhabdoid tumor adipose fin aurochs adolescent obesity Autographivirinae adriamycin-induced nephropathy Avastrovirus Aepyceros Avian coronavirus Aeschynomene Avian erythroblastosis virus African green monkey polyomavirus Avian leukosis virus agonist potency Avian metapneumovirus AH interval Avian nephritis virus Aichi virus Avocado sunblotch viroid airway smooth muscle cell Avsunviroid AKR murine leukemia virus Avsunviroidae Alcelaphinae Bacillus globigii Alcelaphine herpesvirus 1 Bacillus thuringiensis serovar israelensis allergy patient bacterial conjunctivitis Alouattinae bacterium alpaca Banana bunchy top virus Alphacoronavirus 1 barley flour Alphanodavirus Batrachovirus Alpharetrovirus Beak and feather disease virus Alphavirus bean flour amniotic fluid stem cell Beet western yellows virus Ampelovirus Beet yellows virus anal fin Betacoronavirus 1 Andes virus Betanodavirus antagonist potency Betaretrovirus anterior byssus retractor muscle Bhanja virus anterior ethmoidal artery biceps femoris muscle anterior inferior cerebellar artery Bifidobacterium infantis Antilope biliary clearance Emtree Terms Added in May 2015 5 biochemical analysis Cebinae biochemical recurrence cecal ligation and puncture-induced sepsis biolimus eluting coronary stent central volume of distribution Black queen cell virus Cercocebus atys black-backed jackal Cercopithecinae blackbuck Cerdocyon bladder base Cerdocyon thous bladder dome cerebellum granular layer bladder sphincter prosthesis erosion cerebellum molecular layer bladder trigone cerebral artery muscle blast-induced brain injury cerebrospinal fluid-to-plasma ratio blister fluid Ceriporiopsis blood biochemistry Ceriporiopsis subvermispora blood-to-plasma ratio Chabertia body weight management chicken anemia virus bone cement leakage Chikungunya virus bovid Chlamydia muridarum bovine Chlamydiales Bovine adenovirus 3 Chloriridovirus Bovine adenovirus B cholinergic urticaria Bovine