Emtree Terms Added and Changed (May 2015)

This is an overview of new terms added and changes made in the second Emtree release in 2015.

Overall, Emtree has grown by 848 preferred terms (124 drug terms and 724 non-drug terms) compared with the previous version released in January 2015. In total Emtree now counts 71,802 preferred terms.

Because the terms added include replacements for existing preferred terms (which become synonyms of the new terms) as well as completely new concepts, the number of terms added exceeds the net growth in Emtree. Other changes could include the merging of two or more existing preferred terms into a single concept.

The terms added and changed are summarized below and specified in detail on the following pages.

Emtree Terms Added in May 2015

1037 new terms (including 225 replacement terms and promoted synonyms) have been added to Emtree as preferred terms in version May 2015 (compared to January 2015):

 172 drug terms (terms assigned to the Chemicals and Drugs facet).  901 non-drug terms (terms not assigned as Chemicals and Drugs).

The new terms (including the replacement terms and the promoted synonyms) are listed as Terms Added on the following pages. Note that many of these terms will have been indexed prior to 2015 (typically as candidate terms), sometimes for several years, before they were added to Emtree.

Emtree Terms Changed in May 2015

225 terms (48 drug terms and 177 non-drug terms) from Emtree January 2015 have been replaced by 220 different terms in May 2015 (48 drug terms and 172 non-drug terms).

Of these, 144 terms (17 drug terms and 127 non-drug terms) are new (e.g. new generic names for drug chemical names) and have been assigned creation date 2015; the remaining 76 replacement terms (31 drug terms and 45 non-drug terms) were already present in Emtree.

No drug terms were replaced by a non-drug term, no non-drug terms were replaced by a drug term. No preferred terms were deleted.

Changes are presented in alphabetical order of the new terms.

Emtree Terms Added in May 2015 2

Drug terms

1 (6 benzothiazolylsulfonyl) 5 chloro 1h indole 2 amlodipine plus perindopril butanoic acid antazoline plus tetryzoline 1 [2 (benzo[1,2,5]thiadiazol 5 ylamino) 6 (2,6 ascrinvacumab dichlorophenyl)pyrido[2,3 d]pyrimidin 7 yl] 3 asinercept tert butylurea Astragalus root 1 amino 4 (2 asunaprevir plus beclabuvir plus daclatasvir phenylcyclopropylamino)cyclohexane atezolizumab 1,2,3,5 tetrahydro 1 (2 isopropoxyethyl) 2 avacincaptad pegol thioxopyrrolo[3,2 d]pyrimidin 4 one avi 7537 14 o [(1 valyl 3 piperidinylthio)acetyl]mutilin avoralstat 14 o [(3 hydroxymethylphenylthio)acetyl]mutilin axalimogene filolisbac 2 (4 cyclopentylaminophenyl) 1 (2 fluoro 6 bacmid methylbenzoyl) 3 piperidinecarboxylic acid (4 balixafortide methyl 3 trifluoromethylphenyl)amide beta intermedin derivative 2 [4 [3 (4 bromophenyl)acrylamido] 3 bexaglifozin fluorophenyl] 5 benzoxazoleacetic acid bis(8 hydroxy 5 quinolinyl)[4 2 [[3 [4 [3 (diisobutylamino)propyl] 1 (trifluoromethyl)benzyl]amine piperazinyl]propyl]amino] 1h benzimidazole bismuth 207 2 hydroxy 3 (2 thienylacetamido) 1,5,2 bms 824393 dioxaborepane 7 acetic acid bovhyaluronidase azoximer 2 hydroxymethyl 2 methoxymethyl 3 Bovine viral diarrhea virus vaccine quinuclidinone brain natriuretic peptide derivative 2,2 dimethylbutyric acid brolucizumab 3 (2,3 dihydroxypropyl) 6 fluoro 5 (2 fluoro 4 calcium carbonate plus colecalciferol plus iodoanilino) 8 methylpyrido[2,3 d]pyrimidine ibandronic acid 4,7 dione calcium carbonate plus colecalciferol plus 4 [[5 [4 [4 (2 oxazolyl)phenoxy]benzyl] 2,5 zoledronic acid diazabicyclo[2.2.1]hept 2 yl]methyl]benzoic cinhyaluronic acid acid cinnarizine plus domperidone 4 amino n (3 chloro 4 fluorophenyl) n' hydroxy ciraparantag 1,2,5 oxadiazole 3 carboximidamide crisaborole 4' chloro 4 hydroxy 3 methoxychalcone dapagliflozin plus saxagliptin 5 (9 isopropyl 8 methyl 2 morpholino 9h purin 6 daprodustat yl) 2 pyrimidinamine dasabuvir plus ombitasvir plus paritaprevir plus 5 bromo n (2 propynyl) 2 (1h 1,2,4 triazol 1 yl) 4,6 ritonavir pyrimidinediamine decitabine 5,10,15,20 tetrakis(2,6 difluoro 3 n dectrekumab methylsulfamoylphenyl)bacteriochlorin derlotuximab biotin i 131 6 amino 5 [1 (2,6 dichloro 3 fluorophenyl)ethoxy] desfesoterodine n [4 (4 methyl 1 piperazinylcarbonyl)phenyl] 3 deutetrabenazine pyridazinecarboxamide dinotefuran plus pyriproxyfen 6 ethoxy 7 methoxy 2 (2 methylthiophenyl) 3,1 dusquetide benzoxazin 4 one edotreotide ga 68 [4 [(5,6 diphenyl 2 elafibranor pyrazinyl)(isopropyl)amino]butoxy]acetic acid elbasvir plus grazoprevir ach 2928 eleclazine afoxolaner plus milbemycin oxime elgemtumab aglatimagene besadenovec eltrapuldencel T akb 6548 emeramide altiratinib empagliflozin plus linagliptin amg 157 enoblituzumab amifampridine epacadostat amiselimod epetraborole amitriptyline plus chlordiazepoxide eprociclovir Emtree Terms Added in May 2015 3 erlosiban netarsudil etelcalcetide nonstructural protein 5A inhibitor fampridine olifilcon A gamma intermedin derivative olifilcon B gepotidacin olifilcon C gsk 2336805 olifilcon D guadecitabine ombitasvir plus paritaprevir plus ritonavir helper dependent adenoviral vector opicinumab hepacivirin ozanimod hepacivirin inhibitor pexidartinib heparanase inhibitor phoxilium ibiglustat pinometostat idx 320 pleuromutilin antibiotic agent immucillin A pleuromutilin derivative immucillin A triphosphate ppi 461 indimilast pterostilbene indoxacarb plus permethrin radalbuvir indusatumab ravidasvir indusatumab vedotin refanezumab infigratinib relaxin derivative irisin ridinilazole isatuximab rinucumab isunakinra rod derived cone viability factor ivacaftor plus lumacaftor roneparstat labetuzumab govitecan sacubitril plus valsartan lascufloxacin sapanisertib lavamilast seletalisib lilotomab somapacitan lilotomab satetraxetan lutetium lu 177 somavaratan lipotropin derivative spanlecortemlocel lokivetmab sparsentan lopixibat chloride stapuldencel T mereletinib streptocin merestinib tafluprost plus timolol milbemycin oxime tazemetostat motilin derivative teixobactin mycophenolate mofetil tesevatinib n (3 pyridazinyl) 4 [3 (5 trifluoromethyl 2 tesidolumab pyridinyloxy)benzylidene] 1 thymopoietin derivative piperidinecarboxamide thymosin derivative n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 thyrotropin derivative methylpropoxy) 4 pyrimidinyl] 1 tiamulin fumarate azetidinesulfonamide tkm 100802 n [4 [2 [(4 morpholinophenyl)amino] 4 trofinetide pyrimidinyl]phenyl] 2 pyrrolidinecarboxamide vandortuzumab vedotin natriuretic peptide type C derivative vosoritide neladenoson delanate ZMapp nelonicline nemolizumab Emtree Terms Added in May 2015 4

Non-drug terms

47,XXX syndrome Antilopinae 47,XXY syndrome aorta endothelium 47,XYY syndrome Aparavirus 48,XXXX syndrome APD50 48,XXXY syndrome APD90 49,XXXXX syndrome Apophysomyces 49,XXXXY syndrome apparent dissociation constant 5-oxoprolinuria apparent permeability Abelson murine leukemia virus Apple scar skin viroid absorption rate constant Apscaviroid accumulation ratio Arabian horse Achatina architect Acinetobacter anitratus Arctocephalus Acinetobacter calcoaceticus-baumannii complex Arctocephalus gazella Actinoplanes Arctocephalus pusillus action potential amplitude area under the curve ratio activation constant area under the moment curve activation time constant Arteriviridae Acute bee paralysis virus association constant acute hepatitis A association rate constant acute hepatitis B Astragalus (plant) acute hepatitis C Astroviridae acute inflammatory demyelinating Atelinae polyneuropathy atrial fibrillation adenosine-induced hyperemia atypical teratoid rhabdoid tumor adipose fin aurochs adolescent obesity Autographivirinae adriamycin-induced nephropathy Avastrovirus Aepyceros Avian coronavirus Aeschynomene Avian erythroblastosis virus African green monkey polyomavirus Avian leukosis virus agonist potency Avian metapneumovirus AH interval Avian nephritis virus Aichi virus Avocado sunblotch viroid airway smooth muscle cell Avsunviroid AKR murine leukemia virus Avsunviroidae Alcelaphinae Bacillus globigii Alcelaphine herpesvirus 1 Bacillus thuringiensis serovar israelensis allergy patient bacterial conjunctivitis Alouattinae bacterium alpaca Banana bunchy top virus Alphacoronavirus 1 barley flour Alphanodavirus Batrachovirus Alpharetrovirus Beak and feather disease virus Alphavirus bean flour amniotic fluid stem cell Beet western yellows virus Ampelovirus Beet yellows virus anal fin Betacoronavirus 1 Andes virus Betanodavirus antagonist potency Betaretrovirus anterior byssus retractor muscle Bhanja virus anterior ethmoidal artery biceps femoris muscle anterior inferior cerebellar artery Bifidobacterium infantis Antilope biliary clearance Emtree Terms Added in May 2015 5 biochemical analysis Cebinae biochemical recurrence cecal ligation and puncture-induced sepsis biolimus eluting coronary stent central volume of distribution Black queen cell virus Cercocebus atys black-backed jackal Cercopithecinae blackbuck Cerdocyon bladder base Cerdocyon thous bladder dome cerebellum granular layer bladder sphincter prosthesis erosion cerebellum molecular layer bladder trigone cerebral artery muscle blast-induced brain injury cerebrospinal fluid-to-plasma ratio blister fluid Ceriporiopsis blood biochemistry Ceriporiopsis subvermispora blood-to-plasma ratio Chabertia body weight management chicken anemia virus bone cement leakage Chikungunya virus bovid Chlamydia muridarum bovine Chlamydiales Bovine adenovirus 3 Chloriridovirus Bovine adenovirus B cholinergic urticaria Bovine coronavirus chromium release assay Bovine parainfluenza virus 3 chronic atrial fibrillation Bovine respiratory syncytial virus chronic constipation Bovine rotavirus A chronic hepatitis A Bovine rotavirus G6 chronic hepatitis B brachial vein chronic hepatitis C Bracovirus chronic inflammatory pain brain analysis chronic unpredictable stress brain biochemistry Chrysanthemum stunt viroid brain chemistry ciliary process brain cortex layer cingulum (brain) brain-to-plasma ratio citric acid-induced coughing bregma Citrus exocortis viroid Brevibacterium flavum Citrus tristeza virus buckwheat flour clearance at steady-state bulbocavernosus muscle clearance ratio Bunostomum Cocadviroid Caliciviridae Coconut cadang-cadang viroid Callorhinus cognitive remediation therapy Callorhinus ursinus coil migration camelid colliculus Canine adenovirus 1 Colobus Canine adenovirus 2 colon muscle Canine coronavirus compensated liver cirrhosis Canine distemper virus complementary feeding Canis concentration at steady-state capsaicin-induced coughing Conus (snail) cardiac autonomic neuropathy Conus geographus carnivorous fungus corn flour carrageenan-induced paw edema coronary artery muscle cassava flour Coronaviridae catalytic efficiency Coronavirinae catheter dislocation corpus cavernosum muscle catheter leakage cortex layer I caudal fin cortex layer II cavernous artery cortex layer III CC50 cortex layer IV Emtree Terms Added in May 2015 6 cortex layer V Ebolavirus cortex layer VI EC10 cotton pellet-induced granuloma EC90 cottonseed meal Echovirus 6 Coxsackievirus A16 Echovirus 9 Coxsackievirus B3 Echovirus E11 Coxsackievirus B4 effective concentration Cricket paralysis virus efflux rate constant Crigler Najjar syndrome type I Eimeriidae Cripavirus eland Cronobacter universalis electric conductance Cryptococcus (Filobasidiales) enantiomeric ratio Cryptococcus (Tremellales) endoscopic endonasal surgery Cryptococcus curvatus Enterovirus 70 Cryptosporidiidae Enterovirus D CT-SPECT scanner eosinophilic meningitis cuneiform nucleus epidermal stem cell current density epithelial lining fluid cyclophosphamide-induced cystitis Epsilonretrovirus Cylindrospermopsis raciborskii Equine arteritis virus Cystophora Equine rhinitis B virus Cystophora cristata Erythrocebus patas Cystovirus ethmoid sinus mucosa cytotoxic concentration ethmoidal artery deactivation time constant Eudrilus decay time constant Eumetopias dedifferentiated liposarcoma Eumetopias jubatus Deltaretrovirus everolimus eluting coronary stent Deltavirus experimental air pouch inflammation dentate gyrus molecular layer experimental brain injury device embolization experimental carcinogenesis diabetic stomach paresis experimental cognitive defect Didelphis experimental coughing Didelphis albiventris experimental cystitis Didelphis marsupialis experimental dopamine dysregulation syndrome Didelphis virginiana experimental dyskinesia diffusion flux experimental granuloma disse space experimental hyperemia dissociation rate constant experimental hyperthyroidism dorsal anterior cingulate cortex experimental hypothyroidism dorsal fin experimental kidney disease dorsal hippocampus experimental paw edema dorsolateral prefrontal cortex experimental pulmonary hypertension dorsolateral striatum experimental radiation injury dorsomedial prefrontal cortex experimental sepsis dorsomedial striatum experimental stenosis dose experimental systemic lupus erythematosus double-stranded DNA reverse transcribing virus extraction ratio double-stranded DNA virus eye melanoma double-stranded RNA virus Feline calicivirus dried yeast Feline coronavirus Drosophila C virus Feline infectious peritonitis virus Drosophila X virus Feline sarcoma virus drug resistant epilepsy femur diaphysis duodenum muscle femur metaphysis Dutch Warmblood fish meal Eastern equine encephalitis virus flank Emtree Terms Added in May 2015 7 flexor digitorum brevis muscle Hostuviroid Flock house virus Human adenovirus 12 foregut Human adenovirus 7 Fowl aviadenovirus A Human adenovirus A fraction absorbed Human adenovirus B frequency Human adenovirus C Friend murine leukemia virus Human astrovirus frontoparietal cortex Human coronavirus 229E gallbladder muscle Human coronavirus OC43 Gammacoronavirus Human parainfluenza virus 1 Gammaretrovirus Human parainfluenza virus 2 gastric band erosion Human parainfluenza virus 3 gastric hypoacidity Human parainfluenza virus 4 Gibbon ape leukemia virus Human parechovirus Giraffa Human T-lymphotropic virus 1 Giraffidae Human T-lymphotropic virus 2 glaucomatous optic neuropathy Human T-lymphotropic virus 3 glioma stem cell Human T-lymphotropic virus 4 glutamatergic synapse HV interval gluteus medius muscle hypothalamus posterior nucleus gluteus minimus muscle hypoxia-induced pulmonary hypertension golden jackal IC90 grain flour Icelandic horse Grapevine fanleaf virus Ichnovirus Grapevine leafroll-associated virus 3 Ictalurid herpesvirus 1 Grapevine yellow speckle viroid ID50 guanaco ileum muscle half-activation voltage inactivation rate constant half-inactivation voltage inactivation time constant Halichoerus indolent systemic mastocytosis Halichoerus grypus induced aggression test Hantaan virus infantile colic hartebeest Infectious laryngotracheitis virus hartmann procedure infectious salmon anemia virus Harvey murine sarcoma virus Infectious spleen and kidney necrosis virus heart fibroblast inferior gluteal artery heart ganglion inferior longitudinal fasciculus heart left ventricle papillary muscle inferior parietal cortex heart perforation inferior rectus muscle heart right ventricle papillary muscle inferior thyroid artery heart trabecular muscle influx rate constant helicine artery infralimbic cortex hepatic availability infratemporal fossa hepatic extraction ratio inhibition zone Hepatovirus inhibitory concentration Hepatozoidae inhibitory dose Hepatozoon intestinal availability Hepatozoon canis intestinal clearance Hepeviridae intracarotid drug administration hind paw intramural drug administration hindlimb muscle intraneural drug administration Hippopotamidae Isavirus Hippopotamus ischemic mitral valve regurgitation Hippopotamus amphibius Isochrysis HIV survivor Israeli acute paralysis virus Hop stunt viroid itraconazole resistant Candida glabrata horse breed jaguar Emtree Terms Added in May 2015 8 jugular vein thrombosis Lumpy skin disease virus karyotype 48,XXXY Lymphocystis disease virus karyotype 49,XXXXY Lymphocystivirus Kashmir bee virus Lynx canadensis keratinophilic fungus Lynx lynx kidney inner medulla Lynx pardinus kidney outer medulla Lynx rufus kidney subcapsular space Mamastrovirus kinetic parameters mammary gland fat Kirsten murine sarcoma virus Marburgvirus Lactate dehydrogenase-elevating virus Marek's disease virus 1 Lactobacillus delbrueckii subsp. bulgaricus Marek's disease virus 2 lag time Mason-Pfizer monkey virus Lama maxillary palp large intestine muscle maxillary sinus mucosa lateral orbitofrontal cortex maximum clearance lateral prefrontal cortex maximum diastolic potential lateral rectus muscle maximum effect laterodorsal tegmental nucleus maximum flux LC90 mean absorption time LD10 mean channel open time LD100 mean dissolution time LD50 mean transit time LD90 mechanical hyperalgesia LD95 medial entorhinal cortex left common carotid artery medial frontal cortex left stomach vein medial orbitofrontal cortex left subclavian artery medial prefrontal cortex length medial rectus muscle Leopardus medial temporal lobe Leptomonas Megalocytivirus Leptonychotes metabolic clearance Leptonychotes weddellii metabolic stability Leptospira interrogans serovar Australis metamorphopsia Leptospira interrogans serovar Autumnalis metarteriole Leptospira interrogans serovar Canicola MIC50 Leptospira interrogans serovar Copenhageni MIC90 Leptospira interrogans serovar Grippotyphosa middle occipital gyrus Leptospira interrogans serovar Hebdomadis military spouse Leptospira interrogans serovar minimum effective concentration Icterohaemorrhagiae minimum fungicidal concentration Leptospira interrogans serovar Pomona Mirounga Leptospiraceae Mirounga angustirostris lethal concentration Mirounga leonina levator palpebrae superioris muscle mitral valve surgery levodopa-induced dyskinesia Moloney murine leukemia virus linezolid resistant Staphylococcus aureus Moloney murine sarcoma virus lingual artery Monachus lipopolysaccharide-induced sepsis Moniezia liver lobe monocrotaline-induced pulmonary hypertension liver lobule Monodelphis Ljungan virus Monodelphis domestica llama Moschidae log cell kill Moschus lumbar lymph node Mosquito iridescent virus luminal A breast cancer Mouse mammary tumor virus luminal B breast cancer mucosal cancer Emtree Terms Added in May 2015 9 mucosal drug administration paroxysmal atrial fibrillation mucosal melanoma partition ratio multiparametric magnetic resonance imaging Partitiviridae multiple endocrine neoplasia type 1 paw multiple endocrine neoplasia type 2 Pea enation mosaic virus multiple endocrine neoplasia type 2a pea flour multiple endocrine neoplasia type 2b peanut meal Murine coronavirus pectoral fin Murine hepatitis virus Pelagibacter Murine polyomavirus pelvic fin Mycobacteriaceae pelvis ganglion Mycobacterium massiliense perinatal depression mycophage peripheral arterial tonometry Mycoplasma mycoides subsp. capri peripheral volume of distribution Myxicola perirenal fat nape peritumoral drug administration Navicula permanent atrial fibrillation Nebraska calf diarrhea virus persistent atrial fibrillation negative-strand RNA virus Phoca groenlandica nematophagous fungus Phoca vitulina net flux Phocidae neurofibromatosis type 1 phrenic nerve paralysis neurofibromatosis type 2 pianist New World camelid Picobirnaviridae new-onset atrial fibrillation pig no-observed-adverse-effect concentration Pinnipedia no-observed-adverse-effect level plasmablast Nodamura virus Plum pox virus Nodaviridae Polaribacter non-renal clearance pole test nonpigmented ciliary epithelium Polyomaviridae Norwalk virus Polyomavirus nucleus accumbens core Pongo abelii nucleus accumbens shell Pongo pygmaeus nucleus basalis magnocellularis popliteal lymph node nut meal Porcine adenovirus 3 Nyctereutes Porcine adenovirus A observed rate constant Porcine circovirus 1 occipital artery Porcine circovirus 2 occipital face area Porcine reproductive and respiratory syndrome occipitofrontal fasciculus virus ocelot positive-strand RNA virus okapi Pospiviroid Okapia Pospiviroidae olfactory tubercle posterior ethmoidal artery ophthalmic vein Potato leafroll virus orangutan potato meal Orthomyxoviridae Potato spindle tuber viroid Orthoretrovirinae Potato virus X Otariidae Potato virus Y paclitaxel eluting coronary stent PQ interval Pandoraea pre-ejection period panniculus carnosus prelimbic cortex Papillomaviridae Presbytis paranasal sinus mucosa progesterone receptor positive breast cancer parasitic meningitis proliferative diabetic retinopathy paravalvular leak propylthiouracil-induced hypothyroidism Emtree Terms Added in May 2015 10 prostate muscle Salmonella enterica serovar Abortus ovis prostate urethra Salmonella enterica serovar Agona protein-fragment complementation assay Salmonella enterica serovar Anatum Prunus necrotic ringspot virus Salmonella enterica serovar Choleraesuis Pseudomonas aureofaciens Salmonella enterica serovar Derby Pseudonocardia Salmonella enterica serovar Dublin Pseudorabies virus Salmonella enterica serovar Enteritidis Pseudovibrio Salmonella enterica serovar Gallinarum pulmonary artery muscle Salmonella enterica serovar Heidelberg pulmonary artery smooth muscle cell Salmonella enterica serovar Infantis Puma concolor Salmonella enterica serovar Minnesota pupa Salmonella enterica serovar Panama pyloric sphincter Salmonella enterica serovar Paratyphi A Q wave amplitude Salmonella enterica serovar Paratyphi B QRS amplitude Salmonella enterica serovar Paratyphi C QRS interval Salmonella enterica serovar Pullorum QTc interval Salmonella enterica serovar Typhi Quarter horse Salmonella enterica serovar Typhimurium R wave amplitude Salmonella enterica serovar Virchow Rabbit hemorrhagic disease virus Salmonella enterica serovar Wien Radiation murine leukemia virus Sandfly fever Naples virus rapeseed meal Sandfly fever Sicilian virus Raphidocelis Sapajus Raphidocelis subcapitata Sapajus apella Rat coronavirus Sapporo virus rate constant Sarcocystidae Rauscher murine leukemia virus sarcopenic obesity recovery time constant Satellite tobacco necrosis virus rectum muscle satellite virus resident-intruder test scalp psoriasis retina inner nuclear layer Schaffer collateral pathway Retroviridae scopolamine-induced cognitive defect reuniens nucleus sculptor reversal potential Scytalidium reverse transcribing virus Semliki Forest virus Rhinopithecus semolina rice flour sexual behavior test Rice stripe virus Shetland pony Rice tungro bacilliform virus shock-induced aggression test right common carotid artery Simian hemorrhagic fever virus right stomach vein single-stranded DNA virus right subclavian artery single-stranded RNA reverse transcribing virus robot assisted surgery single-stranded RNA virus root flour sirolimus eluting coronary stent Ross River virus sitosterolemia rostral ventrolateral medulla Skeletonema rostral ventromedial medulla slope factor Rous sarcoma virus small intestine muscle Rubivirus sorghum flour ruminant soy food rye flour soybean meal S wave amplitude speckle tracking echocardiography Saffold virus Sphaeropleales Saimiriinae spinal cord infarction salience network Spirochaetaceae Salmonella enterica serovar Abortus splenic flexure Salmonella enterica serovar Abortus equi Sporobolomyces Emtree Terms Added in May 2015 11

Spumaretrovirinae toxic concentration Spumavirus toxic dose St. Louis encephalitis virus trachea cartilage Standardbred horse Trachypithecus stent occlusion Tragelaphus stomach artery transcranial electrical stimulation stomach vein Tremovirus Streptococcus zooepidemicus Trichothecium subcallosal gyrus Trypanosoma brucei gambiense subesophageal ganglion Trypanosoma brucei rhodesiense submandibular gland duct Trypanosomatidae submandibular lymph node TUNEL assay subplantar drug administration Turkey coronavirus subretinal drug administration Turkey herpesvirus substrate concentration Turnip crinkle virus subtenon drug administration turnover number suid two dimensional speckle tracking Sulfolobus spindle-shaped virus 1 echocardiography sunflower meal Ulocladium superior cerebellar artery unbound fraction superior longitudinal fasciculus urine biochemistry superior rectus muscle urine chemistry superior thyroid artery Urocyon supraesophageal ganglion Urocyon cinereoargenteus surface area vascular smooth muscle cell systemic juvenile idiopathic arthritis Venezuelan equine encephalitis virus T-peak to T-end ventral hippocampus tail vein ventral pallidum talonavicular joint ventral striatum Taura syndrome virus ventrolateral prefrontal cortex taurine cattle vertebra arch TC50 vertebra spinous process TD50 Vesicular exanthema of swine virus terminal ileum vestibular migraine Theiler's murine encephalomyelitis virus Vicugna (genus) Theilovirus vicuna Thogoto virus violinist Thogotovirus visual artist thoracic ganglion volume Thoroughbred horse volume of distribution ratio three dimensional speckle tracking Volvox carteri echocardiography Vulpes thymidine incorporation assay Walleye dermal sarcoma virus thyroid artery walrus tibia epiphysis weight loss program time-dependent inhibition well differentiated liposarcoma Tipula iridescent virus West Nile virus Tobacco streak virus Western equine encephalitis virus tofu wheat flour Togaviridae wildebeest Tomato bushy stunt virus Woolly monkey sarcoma virus Tomato spotted wilt virus Yellow fever virus tomato yellow leaf curl virus Zaire ebolavirus Tombusviridae Zalophus Torovirinae Zalophus californianus Torula zebu Toscana virus zotarolimus eluting coronary stent Emtree Terms Changed in May 2015 12

Drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term

1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 uo 126 dicyanobutadiene* abrineurin* recombinant brain derived neurotrophic factor alpha sarcoglycan* adhalin alvelestat* azd 9668 amifampridine 3,4 diaminopyridine amitriptyline plus chlordiazepoxide limbitrol amphotericin B cholesterol sulfate* amphotericin B plus cholesterol sulfate becaplermin* recombinant platelet derived growth factor BB carnosic acid* salvin certoparin* monoembolex decitabine 5 aza 2' deoxycytidine deutetrabenazine dutetrabenazine dextropropoxyphene plus paracetamol* digesic digoxin* coragoxine elafibranor 2 [2,6 dimethyl 4 [3 [4 (methylthio)phenyl] 3 oxo 1 propenyl]phenoxy] 2 methylpropionic acid emeramide n,n' bis(2 mercaptoethyl)isophthalamide epetraborole 3 aminomethyl 1,3 dihydro 1 hydroxy 7 (3 hydroxypropyl) 2,1 benzoxaborole epidermal growth factor* beta urogastrone eprociclovir 9 [1,2 bis(hydroxymethyl)cyclopropylmethyl]guanine etelcalcetide velcalcetide ethinylestradiol plus levonorgestrel* trisiston fampridine 4 aminopyridine infigratinib 3 (2,6 dichloro 3,5 dimethoxyphenyl) 1 [6 [[4 (4 ethyl 1 piperazinyl)phenyl]amino] 4 pyrimidinyl] 1 methylurea k 252a* sf 2370 kalinin* epiligrin ketoprofen* actron lucatumumab* chir 12.12 multidrug resistance associated protein 2* multidrug resistance protein 2 multidrug resistance associated protein 6* multidrug resistance protein 6 mycophenolate mofetil mycophenolic acid 2 morpholinoethyl ester n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 n [2 (2,3 difluorobenzylthio) 6 (2,3 dihydroxy 1 methylpropoxy) 4 pyrimidinyl] 1 methylpropoxy) 4 pyrimiidinyl] 1 azetidinesulfonamide azetidinesulfonamide navelbine* vinorelbine ditartrate necuparanib* tafoxiparin neomycin plus polymyxin B* statrol neurokinin 1 receptor* substance P receptor olamufloxacin* 5 amino 7 (7 amino 5 azaspiro[2.4]hept 5 yl) 1 cyclopropyl 6 fluoro 1,4 dihydro 8 methyl 4 oxo 3 quinolinecarboxylic acid pinometostat 2 (6 amino 9h purin 9 yl) 5 [[[3 [2 (5 tert butyl 1h benzimidazol 2 yl)ethyl]cyclobutyl](isopropyl)amino]methyl]tetrahydro furan 3,4 diol relebactam* 7 oxo n (4 piperidinyl) 1,6 diazabicyclo[3.2.1]octane 2 carboxamide sacubitril plus valsartan 3 (1 biphenyl 4 ylmethyl 3 ethoxycarbonyl 1 butylcarbamoyl)propionic acid plus valsartan

Emtree Terms Changed in May 2015 13 sapanisertib 3 (2 amino 5 benzoxazolyl) 1 isopropyl 1h pyrazolo[3,4 d]pyrimidin 4 amine Senna extract* x prep sitogluside* daucosterol stem cell factor* steel factor tadocizumab* ym 337 temoporfin* tetrakis(3 hydroxyphenyl)chlorin tesevatinib xl 647 thrombopoietin* megakaryocyte growth and development factor transcription factor ARNTL* protein BMAL1

Emtree Terms Changed in May 2015 14

Non-drug terms

New or pre-existing term Old (replaced) term * indicates pre-existing term These terms become synonyms of the new term

47,XXY syndrome 47, XXY 48,XXXY syndrome 48, XXXY 49,XXXXY syndrome 49, XXXXY Abelson murine leukemia virus Abelson murine leukemia oncovirus Acinetobacter anitratus Acinetobacter calcoaceticus subsp. anitratus acute myeloblastic leukemia* acute granulocytic leukemia AKR murine leukemia virus Gross leukemia virus Aliivibrio salmonicida* Vibrio salmonicida Alphavirus Alpha virus anaphylaxis* anaphylactic shock aphthous stomatitis* aphthous ulcer Astragalus (plant) Astragalus plant Astroviridae Astrovirus atrial fibrillation heart atrium fibrillation aurochs Bos primigenius Autographivirinae Autographvirinae autoimmune thyroiditis* lymphocytic thyroiditis Avian erythroblastosis virus Avian erythroblastosis oncovirus Avian leukosis virus Avian leukosis oncovirus Avian metapneumovirus Avian pneumovirus Bacillus globigii Bacillus subtilis subsp. globigii bacterium Bacteria Bifidobacterium infantis Bifidobacterium longum subsp. infantis bovid bovids bovine Bovinae Bovine adenovirus B bovine adenovirus Bovine viral diarrhea virus 1* Bovine diarrhea virus Bromoviridae* Oleavirus Caliciviridae Calicivirus Canine distemper virus Canine distemper morbillivirus Chikungunya virus Chikungunya alphavirus chromium release assay chromium 51 release Clavispora* Candida haemulonis complex regional pain syndrome type II* causalgia congenital malformation* birth defect Conus (snail) Conus snail Coriolaceae* Lenzites coronary artery atherosclerosis* atherosclerotic cardiovascular disease Coronaviridae Coronavirus Coxsackievirus B3 Coxsackie virus B3 Coxsackievirus B4 Coxsackie virus B4 Cronobacter universalis Cronobacter genomospecies CT-SPECT scanner CT SPECT scanner Didymella* Didymella rabiei double-stranded RNA virus Diplorna virus Dunaliella salina* Dunaliella bardawil Eastern equine encephalitis virus Eastern equine encephalomyelitis virus Ebolavirus Ebola virus Echovirus E11 echovirus 11 Enterobacter cloacae Enterobacter cloacae subsp. dissolvens Enterovirus Coxsackie virus Enterovirus Coxsackie virus A Enterovirus B Coxsackie virus B Emtree Terms Changed in May 2015 15

Enterovirus B Echo virus Equine arteritis virus Equine viral arteritis virus Eurotiales* Hamigera (ascomycete) female genital tract cancer* gynecologic cancer Filobasidiella* Cryptococcus Friend murine leukemia virus Friend leukemia virus Gibbon ape leukemia virus Gibbon leukemia virus Gluconobacter oxydans* Gluconobacter suboxydans Harvey murine sarcoma virus Harvey sarcoma oncovirus Hepadnaviridae* Hepadnavirus Human adenovirus 12 Adenovirus 12 Human adenovirus 7 Adenovirus 7 Human adenovirus C Human adenovirus Human parainfluenza virus 1 Parainfluenza virus 1 Human parainfluenza virus 2 Parainfluenza virus 2 Human parainfluenza virus 3 Parainfluenza virus 3 Human parainfluenza virus 4 Parainfluenza virus 4 Human T-lymphotropic virus 1 Human T cell leukemia virus 1 Human T-lymphotropic virus 2 Human T cell leukemia virus 2 Human T-lymphotropic virus 3 Human T lymphotropic virus 3 Human T-lymphotropic virus 4 Human T lymphotropic virus 4 hypergammaglobulinemia* hyperimmunoglobulinemia Hypocreales Hypomyces Hypocreales Hypomyces rosellus idiopathic thrombocytopenic purpura* autoimmune thrombocytopenia infantile spasm* West syndrome kidney artery* renal artery Kirsten murine sarcoma virus Kirsten sarcoma oncovirus Kluyvera* Kluyvera intermedia Lactate dehydrogenase-elevating virus Lactic dehydrogenase togavirus Lactobacillus delbrueckii subsp. bulgaricus Lactobacillus bulgaricus LD50 LD 50 leukemia virus* Leukovirus linezolid resistant Staphylococcus aureus linezolid-resistant Staphylococcus aureus Marburgvirus Marburg virus Mason-Pfizer monkey virus Mason Pfizer monkey virus medial longitudinal fasciculus* medial longitudinal bundle Micrococcaceae Dermacoccaceae Micrococcaceae Kytococcus Moloney murine leukemia virus Moloney leukemia oncovirus Moloney murine sarcoma virus Moloney murine sarcoma oncovirus Mouse mammary tumor virus Mouse mammary tumor oncovirus Mucorales* Actinomucor mucosal drug administration mucosal administration multiple endocrine neoplasia* multiple endocrine adenomatosis multiple endocrine neoplasia type 2a Sipple syndrome Murine hepatitis virus Murine hepatitis coronavirus Mycobacterium massiliense Mycobacterium abscessus subsp. bolletii Nodaviridae Nodavirus orangutan orang utan Orthomyxoviridae Orthomyxovirus Orthoretrovirinae Oncovirinae Papillomaviridae Papilloma virus Paramyxovirinae* Parainfluenza virus paroxysmal atrial fibrillation paroxysmal heart atrium fibrillation patella ligament* patella tendon Pectobacterium carotovorum* Pectobacterium carotovorum subsp. carotovorum Peptostreptococcaceae* Terrisporobacter pig swine Emtree Terms Changed in May 2015 16 pigmented nevus* melanocytic nevus Pinnipedia seal pollen allergy* hay fever Polyomavirus Polyoma virus Porcine adenovirus A Porcine adenovirus Pseudomonas aureofaciens Pseudomonas chlororaphis subsp. aureofaciens Pseudorabies virus Pseudorabies herpetovirus pupa pupa (life cycle stage) Radiation murine leukemia virus Radiation leukemia virus Raphidocelis Pseudokirchneriella Rauscher murine leukemia virus Rauscher leukemia virus Retroviridae Retrovirus Ross River virus Ross River alpha virus Rous sarcoma virus Rous sarcoma oncovirus Saccharomycetales Hyphopichia Saccharomycetales Millerozyma Salmonella enterica* Salmonella enterica subsp. enterica Salmonella enterica serovar Abortus Salmonella enterica subsp. enterica serovar Abortus Salmonella enterica serovar Agona Salmonella enterica subsp. enterica serovar Agona Salmonella enterica serovar Anatum Salmonella enterica subsp. enterica serovar Anatum Salmonella enterica serovar Choleraesuis Salmonella enterica subsp. enterica serovar Choleraesuis Salmonella enterica serovar Derby Salmonella enterica subsp. enterica serovar Derby Salmonella enterica serovar Dublin Salmonella enterica subsp. enterica serovar Dublin Salmonella enterica serovar Enteritidis Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enterica serovar Gallinarum Salmonella enterica subsp. enterica serovar Gallinarum Salmonella enterica serovar Heidelberg Salmonella enterica subsp. enterica serovar Heidelberg Salmonella enterica serovar Infantis Salmonella enterica subsp. enterica serovar Infantis Salmonella enterica serovar Minnesota Salmonella minnesota Salmonella enterica serovar Panama Salmonella enterica subsp. enterica serovar Panama Salmonella enterica serovar Paratyphi A Salmonella enterica subsp. enterica serovar Paratyphi A Salmonella enterica serovar Paratyphi B Salmonella enterica subsp. enterica serovar Paratyphi B Salmonella enterica serovar Paratyphi C Salmonella paratyphi C Salmonella enterica serovar Pullorum Salmonella enterica subsp. enterica serovar Pullorum Salmonella enterica serovar Typhi Salmonella enterica subsp. enterica serovar Typhi Salmonella enterica serovar Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium Salmonella enterica serovar Virchow Salmonella enterica subsp. enterica serovar Virchow Salmonella enterica serovar Wien Salmonella wien Sapajus apella Cebus apella satellite virus defective virus secretory otitis media* middle ear effusion Semliki Forest virus Semliki Forest alphavirus Spumavirus Spuma virus St. Louis encephalitis virus St Louis flavivirus staphylococcal scalded skin syndrome* newborn exfoliative dermatitis Streptococcus zooepidemicus Streptococcus equi subsp. zooepidemicus stripe rust* yellow rust taurine cattle Bos taurus Teladorsagia circumcincta* Ostertagia circumcincta tendon entrapment* stenosing tenosynovitis Theiler's murine encephalomyelitis virus Murine encephalomyelitis virus Togaviridae Togavirus Tricholoma matsutake* Tricholoma nauseosum Trypanosoma brucei gambiense Trypanosoma gambiense Trypanosoma brucei rhodesiense Trypanosoma rhodesiense TUNEL assay nick end labeling urethra stenosis* urethra stricture Venezuelan equine encephalitis virus Venezuelan equine encephalomyelitis alphavirus volume of distribution* apparent distribution volume Waldenstroem macroglobulinemia* macroglobulinemia Emtree Terms Changed in May 2015 17

West Nile virus West Nile flavivirus Western equine encephalitis virus Western equine encephalomyelitis alphavirus Woolly monkey sarcoma virus Simian sarcoma virus Yellow fever virus Yellow fever flavivirus zebu Bos indicus