B Cells- Lymphomas Are "Blood Risky Unforeseen Developments"

Total Page:16

File Type:pdf, Size:1020Kb

B Cells- Lymphomas Are ogenesis in & rc a M C u t f a o g l e a n e n Journal of Carcinogenesis & r s u i s o J ISSN: 2157-2518 Mutagenesis Editorial B Cells- Lymphomas are "Blood Risky Unforeseen Developments" Ian Stuart Zagon* Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan ABSTRACT The B-cell lymphomas are sorts of lymphoma impacting B cells. Lymphomas are "blood risky unforeseen developments" in the lymph network centers. They develop extensively more a colossal bit of the time in more orchestrated adults and in immunocompromised individuals. B-cell lymphomas merge both Hodgkin's lymphomas and most non-Hodgkin lymphomas. They are routinely separated into low and high assessment, consistently identifying with lazy (slow-production) lymphomas and genuine lymphomas, uninhibitedly. As a speculation, dormant lymphomas respond to treatment and are checked (evaporating) with broadened length resoluteness of various years, at any rate are not reestablished. Phenomenal lymphomas regularly require concentrated prescriptions, with some having fair open entryways for an enduring fix. Keywords: lymphomas; Hodgkin's lymphomas; Non-Hodgkin lymphomas DESCRIPTION Small lymphocytic lymphoma (notwithstanding called reliable Want and treatment depends on the specific kind of lymphoma lymphocytic leukemia, CLL correspondingly as the stage and grade. Treatment joins Mantle Cell Lymphoma (MCL) radiation and chemotherapy. Early phase lazy B-cell lymphomas can consistently be treated with radiation alone, with huge Exceptional length non-emphasize. Early phase extraordinary ailment is The abundance structures are on a very basic level less regular treated with chemotherapy and consistently radiation, with a 70-90% fix rate. Late-stage moderate lymphomas are to a great DLBCL arrangements or sub-sorts of extent left untreated and checked until they progress. Late-stage Primary mediastinal (thymic) gigantic B cell lymphoma genuine disease is treated with chemotherapy, with fix advancements of over 70% T cell/histiocyte-rich huge B-cell lymphoma EBV positive diffuse colossal B-cell lymphoma of the more Types arranged There are different sorts of lymphomas including B cells. The Diffuse huge B-cell lymphoma related with steady exacerbation most consistently used gathering system is the WHO interest, a Fibrin-related diffuse huge B-cell lymphoma blending of mutiple, more settled plan structures. Primary testicular diffuse huge B-cell lymphoma Typical Burkitt's lymphoma Five record for basically three out of four patients with non- Lymphoplasmacytic lymphoma, which may show as Hodgkin lymphoma Waldenström's macroglobulinemia Diffuse huge B-cell lymphoma (DLBCL) Nodal Irrelevant Ione B Cell Lymphoma (NMZL) Follicular lymphoma Splenic Outskirts Zone Lymphoma (SMZL) Correspondence to: Ian Stuart Zagon, Division of Applied Life Science, Graduate School of Engineering, Sojo University, Kumamoto, Japan, Tel: +81 96 326 3965; E-mail: [email protected] Received: November 13, 2020; Accepted: November 27, 2020; Published: December 4, 2020 Citation: Zagon IS (2020) B cells- Lymphomas are "Blood Risky Unforeseen Developments". J Carcinog Mutagen. S15:e001. Copyright: © 2020 Zagon IS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. J Carcinog Mutagen, Iss.S15 No:e001 5 Zagon IS Intravascular lymphomas varieties antibodies. Furthermore, B cells present antigens (they are similarly named able antigen-presenting cells (APCs)) and Intravascular gigantic B-cell lymphoma conveyance cytokines. In warm blooded creatures, B cells make Intravascular NK-cell lymphoma in the bone marrow, which is at the purpose of union of most bones. In winged animals, B cells make in the bursa of Intravascular T-cell lymphoma Fabricius, a lymphoid organ where they were first found by Primary transmission lymphoma Chang and Glick, (B for bursa) and not from bone marrow as all around perceived. Lymphomatoid granulomatosis Primary central generous framework lymphoma DISCUSSION AND CONCLUSION ALK+ huge B-cell lymphoma Lymphoma is a gathering of blood malignancies that make from lymphocytes (quite a white platelet). The name reliably proposes Plasmablastic lymphoma fundamentally the hurting structures instead of each such Large B-cell lymphoma arising in HHV8-related multicentric tumor. Signs a great deal may harden expanded lymph centers, Castleman's affliction fever, soaking sweats, unintended weight decrease, shivering, and eagerly feeling tired. The made lymph networks are B cells, in any case called B lymphocytes, are a significant white routinely straightforward. The sweats are consistently ordinary platelet of the lymphocyte subtype. They work in the humoral around night. obstruction section of the versatile safe system by delivering J Carcinog Mutagen, Iss.S15 No:e001 6.
Recommended publications
  • Primary Spinal Intramedullary Lymphoma: a Case Report and Review of the Litera- Ture
    Central JSM Neurosurgery and Spine Case Report *Corresponding author Feyza Karagoz Guzey, Topkapi Mahallesi, Kahalbagi Sokak 46/2 Fatih Istanbul, Turkey, 34093, Tel: Primary Spinal Intramedullary 905326334032; Email: Submitted: 28 November 2014 Lymphoma: A Case Report and Accepted: 05 January 2015 Published: 08 January 2015 Copyright Review of the Literature © 2015 Guzey et al. Feyza Karagoz Guzey1*, Yucel Hıtay1, Cihan Isler1, Abdurrahim OPEN ACCESS Tas1, Ozgur Aktas1, Azmi Tufan1, Mustafa Vatansever1 and Aslı Keywords 2 Kahraman Akkalp • Central nervous system lymphoma 1Department of Neurosurgery, Bagcilar Research and Training Hospital, Turkey • Lymphoma 2Department of Neurosurgery and Pathology, Bagcilar Research and Training Hospital, • Nonhodgkin lymphoma Turkey • Spinal intramedullary lymphoma • Spinal intramedullary tumor Abstract Background: Primary spinal intramedullary lymphoma is a very rare lesion. It has not specific laboratory or radiologic findings. Therefore false and late diagnosis is frequent. Case Report and Literature Review: A 55 year-old lady with multifocal primary spinal intramedullary B-cell non-Hodgkin’s lymphoma was reported. Review of literature yielded 45 cases with primary spinal intramedullary lymphoma and clinical and radiological characteristics of these 46 cases were evaluated. Results: Male/female ratio was 24/22. Median age of the patients was 51.5 years for all cases except a series consisting 14 cases to be reported in an article in which detailed data case by case was not given. Median age of those 14 cases was 62.5. Most of the cases were localized in the cervical and then thoracic segments. Multifocal spinal tumors were found in 12 patients. Most of the patients were admitted with rapidly progressing myelopathy symptoms and signs.
    [Show full text]
  • Diffuse Large B-Cell Lymphoma of the Central Nervous System
    Open Journal of Pathology, 2012, 2, 133-139 1 Published Online October 2012 (http://www.SciRP.org/journal/ojpathology) http://dx.doi.org/10.4236/ojpathology.2012.24024 Diffuse Large B-Cell Lymphoma of the Central Nervous System. Immunophenotype, Clinicopathological Features and Differential Diagnosis Mónica Belinda Romero-Guadarrama1*, María Esther Gutiérrez Díaz-Ceballos1, Fiacro Jiménez-Ponce2, Samantha Thingen-Velarde3 1Unit Pathology Hospital General de México, Medicine School, Autonomous University of Mexico, Mexico City, Mexico; 2Neurosur- gery Unit Hospital General de México, Mexico City, Mexico; 3Hemathology Service, Hospital General de México, Mexico City, Mexico. Email: *[email protected] Received June 14th, 2012; revised July 12th, 2012; accepted July 23rd, 2012 ABSTRACT Background: Diffuse large B-cell lymphomas of the central nervous system (DLBCL CNS) represent less than 1% of all lymphomas and between 2% and 3% of all cerebral tumors. They occur in adults of 60 years of age or more. The objective of this work is to describe the clinical-pathological characteristics, the immunophenotype and the differential diagnosis. Clinical Case: From the files of the surgical pathology unit we found four cases of primary diffuse large B cell lymphoma of the central nervous system in a 6-year period. Three corresponded to women over 47 years of age and the other to a 42-year-old man. The time of evolution was between 2 and 4 months. The symptoms were headache, blurred vision, hemiparesis, and seizures. Localization was in the pineal region, the frontal, parietal regions, and the right thalamus. Morphologically, large lymphoid cells with a diffuse growth pattern and necrosis were observed.
    [Show full text]
  • Intravascular Lymphoma
    540 J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.2003.033662 on 16 March 2005. Downloaded from PAPER Intravascular lymphoma: magnetic resonance imaging correlates of disease dynamics within the central nervous system J M Baehring, C Henchcliffe, C J Ledezma, R Fulbright, F H Hochberg ............................................................................................................................... J Neurol Neurosurg Psychiatry 2005;76:540–544. doi: 10.1136/jnnp.2003.033662 Background: Intravascular lymphoma (IVL) is a rare non-Hodgkin’s lymphoma with relative predilection for the central nervous system. In the absence of extraneural manifestations, the disease is not recognised until autopsy in the majority of cases underlining the need for new clinical markers. Methods: This is a retrospective series of five patients with IVL seen at a single institution over three years. An advanced magnetic resonance imaging (MRI) protocol was performed at various time points prior to diagnosis and during treatment. See end of article for authors’ affiliations Results: MRI revealed multiple lesions scattered throughout the cerebral hemispheres; the brainstem, ....................... cerebellum, and spinal cord were less frequently involved. On initial presentation, hyperintense lesions were seen on diffusion weighted images suggestive of ischaemia in three of four patients in whom the Correspondence to: F H Hochberg, images were obtained at that time point. In four patients lesions were also identifiable as hyperintense Massachusetts General areas on fluid attenuated inversion recovery (FLAIR) sequences. Initial contrast enhancement was Hospital, Brain Tumor encountered in three cases. Diffusion weighted imaging lesions either vanished or followed the typical Center, Cox 315, Boston, MA 02114, USA; pattern of an ischaemic small vessel stroke with evolution of abnormal FLAIR signal followed by [email protected] enhancement with gadolinium in the subacute stage and tissue loss in the chronic stage.
    [Show full text]
  • Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis
    Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters Citation Rahmani, Mahboubeh, Stephanie Halene, and Mina L. Xu. 2018. “Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis.” BioMed Research International 2018 (1): 9413015. doi:10.1155/2018/9413015. http://dx.doi.org/10.1155/2018/9413015. Published Version doi:10.1155/2018/9413015 Citable link http://nrs.harvard.edu/urn-3:HUL.InstRepos:37160263 Terms of Use This article was downloaded from Harvard University’s DASH repository, and is made available under the terms and conditions applicable to Other Posted Material, as set forth at http:// nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of- use#LAA Hindawi BioMed Research International Volume 2018, Article ID 9413015, 6 pages https://doi.org/10.1155/2018/9413015 Research Article Small Cell Variant of Intravascular Large B-Cell Lymphoma: Highlighting a Potentially Fatal and Easily Missed Diagnosis Mahboubeh Rahmani ,1 Stephanie Halene,2 and Mina L. Xu3 1 Department of Pathology, Harvard Medical School, Boston, MA, USA 2Department of Internal Medicine, Hematology Division, Yale University School of Medicine, New Haven, CT, USA 3Department of Pathology and Laboratory Medicine, Yale University School of Medicine, New Haven, CT, USA Correspondence should be addressed to Mahboubeh Rahmani; [email protected] Received 26 November 2017; Revised 23 January 2018; Accepted 4 March 2018; Published 3 April 2018 Academic Editor: Francesco Di Raimondo Copyright © 2018 Mahboubeh Rahmani et al.
    [Show full text]
  • Comparison of Clinical Diagnoses and Autopsy Findings in 54 Cases with Lymphoid Neoplasms
    Journal of Hematopathology (2019) 12:67–74 https://doi.org/10.1007/s12308-019-00357-9 ORIGINAL ARTICLE Comparison of clinical diagnoses and autopsy findings in 54 cases with lymphoid neoplasms Lara Abraham1 & Hans Kreipe1 & Kais Hussein1 Received: 23 August 2018 /Accepted: 3 May 2019 /Published online: 21 May 2019 # Springer-Verlag GmbH Germany, part of Springer Nature 2019 Abstract There are few systematic analyses on autopsy findings of patients with lymphoid neoplasms. Autopsy cases with (n = 54) and without (n = 50) lymphoid neoplasms were compared for this study. Neoplasms found were B cell lymphomas (n =30/54,56%), plasmacytomas (n = 15/54, 28%), T cell lymphomas (n = 7/54, 13%), Hodgkin lymphomas (n = 2/54, 3%) and solid tumours (n = 7/54, 13%). In the control group, 12/50 (24%) cases had solid tumours. Autopsy alone identified the previously unknown lymphoid neoplasm in 10/54 (18%) cases, whilst only 1/50 (2%) previously unknown carcinoma was found in the control group. Cardiac/respiratory failure was the most frequent cause of death in the lymphoid neoplasm group (n =35/54,65%)aswellasin the control group (n = 36/50, 72%). In 8/54 (15%) cases with lymphoid neoplasms and 5/50 (10%) control cases, class I discrepancies were found. This study shows the high rate of autopsy-verified lymphoid neoplasms and unrecognised co- morbidities. Keywords Autopsy . Post-mortem examination . Lymphoma . Plasmacytoma Introduction organ involvement or only post-transplant lymphoprolifera- tive diseases (PTLD) [7–9]. Most of these studies have no The diagnosis of lymphomas and plasmacytomas is a routine control group without haematological neoplasms.
    [Show full text]
  • Intravascular Lymphoma of the Central Nervous System Presenting As Multiple Cerebral Infarctions
    CASE REPORT Nagoya J. Med. Sci. 74. 353 ~ 358, 2012 INTRAVASCULAR LYMPHOMA OF THE CENTRAL NERVOUS SYSTEM PRESENTING AS MULTIPLE CEREBRAL INFARCTIONS HIROYUKI MOMOTA1,2, YOSHITAKA NARITA1, YASUJI MIYAKITA1 and SOICHIRO SHIBUI1 1Neurosurgery Division, National Cancer Center Hospital, Tokyo, Japan 2Department of Neurosurgery, Nagoya University Hospital, Nagoya, Japan ABSTRACT A 67-year-old woman presented with an acute onset of left-sided weakness. Magnetic resonance (MR) imaging revealed multiple cerebral infarctions and gadolinium-enhanced lesions in both cerebral hemispheres. Her symptoms once improved after starting steroid treatment; however, soon developed consciousness disturbance and hemiparesis on the left side. She was referred to our hospital where she underwent stereotactic needle biopsy, that revealed an intravascular large B-cell lymphoma in the cerebrum. She received high-dose methotrexate chemotherapy followed by whole-brain radiation therapy, and the MR findings improved. However, her medical condition gradually worsened, and she died 6 months after disease onset. Intravascular lymphoma (IVL) limited to the central nervous system (CNS) is very rare, and the optimal treatment for this medical condition has not been established yet. IVLs showing only neurologic manifestations might be overlooked or misdiagnosed as cerebral infarctions. Here, we present a case of CNS IVL, with its radiographic and pathologic features and treatment with high-dose methotrexate chemotherapy. Key Words: Intravascular lymphoma, Central nervous system, Cerebral infarction This is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (http://creativecommons.org/licenses/by-nc-nd/4.0/). INTRODUCTION Intravascular lymphoma (IVL) is a rare variant of mature B-cell neoplasms restricted to the vascular lumina, and this condition preferentially affects the central nervous system (CNS) and skin.
    [Show full text]
  • Intravascular Lymphoma Mimicking Acute Haemorrhagic
    Case Report iMedPub Journals Journal of Neurology and Neuroscience 2021 www.imedpub.com ISSN 2171-6625 Vol.12 No.5:367 Intravascular Lymphoma Mimicking Acute Jonathan Naftali1*, Gilad Itchaki2, Haemorrhagic Leucoencephalitis Maor Mermelstein1 and Felix Benninger1 Abstract 1 Department of Neurology, Rabin Medical Center, Petach Tikva, Israel Intravascular lymphoma and Acute Haemorrhagic Leucoencephalitis are rapidly 2 Institute of Hematology, Rabin Medical progressive diseases with poor prognosis. Differentiated between CNS variant Center, Petach Tikva, Israel of IVL and AHLE can be challenging, as they both can be clinically identical. Our case is about 63-year-old female, who presented with rapid onset of cognitive impairment. During her hospitalization, another rapid deterioration has occurred, *Corresponding author: Naftali J and she became tetraplegic, with aphasia, and obtunded. Brain MRI showed many confluent lesions in the white matter, with. Most lesions appeared hemorrhagic. [email protected] After the MRI, a radiological and clinical differential diagnosis between intravascular lymphoma and Acute Haemorrhagic Leucoencephalitis was made. Rapid brain Department of Neurology, Rabin Medical biopsy has revealed the diagnosis of IVL. She had a good responsive to therapy, Center, Petach Tikva, Israel. and regained most of her cognitive and motor functions. Keywords: Intra-vascular lymphoma; Acute haemorrhagic leucoencephalitis Tel: +972-504807751 March 24, 2021; May 07, 2021; May 14, 2021 Received: Accepted: Published: Citation: Naftali J, Itchaki G, Mermelstein M, Benninger F (2021) Intravascular Lymphoma Mimicking Acute Introduction Haemorrhagic Leucoencephalitis. J Neurol Neurosci Vol.12 No.5:367 Intravascular Lymphoma (IVL) is a rare lymphoma, most commonly of B-cell origin. It is classified according to epidemiology and organ involvement: patients of Western variant present the patient was alert but disoriented and anomic, executes frequently with CNS and skin involvement, while in those of partial commands without any other focal neurological signs.
    [Show full text]
  • Intravascular Large B-Cell Lymphoma: a Case Serie
    Case Report | Iran J Pathol. 2020; 15(4): 346-350 Iranian Journal of Pathology | ISSN: 2345-3656 Intravascular Large B-cell Lymphoma: A Case Serie Fereshteh Ameli1*, Fatemeh Nili Ahmad Abadi1, Hana Saffar1 1. Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran KEYWORDS ABSTRACT Extranodal large B-cell lymphoma, One of the rare variants of extranodal large B-cell lymphoma is intravascular large Intravascular lymphoma, B-cell lymphoma (IVLBCL). Characteristics of IVLBCL include intraluminal selective Fever of Unknown Origin (FUO) proliferation of atypical lymphoid cells in small to medium-sized vessels. The etiologic Scan to discover online of IVLBCL is unknown, but due to the growth pattern of this tumor, it is speculated that IVLBCL is caused by a defect in homing receptor of tumor cells. IVLBCL can involve any organ but central nervous system, lungs, and skin are the most involved sites. IVLBCL does not usually involve lymph nodes. IVLBCL mainly occurs in the middle aged to elderly population with a slight male predominance. Generally, IVLBCL is aggressive and rapidly fatal if left untreated. Main Subjects: We here reported two cases of IVLBCL who succumbed to the disease at initial phase Hematopathology of treatment to emphasize the difficulty in diagnosis of IVLBCL due to its exclusive intravascular growth pattern and fulminant clinical course. Received 04 Jan 2020; Accepted 10 April 2020; Published Online 16 July 2020; 10.30699/ijp.2020.119590.2299 Fereshteh Ameli; Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran Corresponding Information: University of Medical Sciences, Tehran, Iran.
    [Show full text]
  • WHO/EORTC Classification of Cutaneous Lymphomas 2005: Histological and Molecular Aspects
    J Cutan Pathol 2005: 32: 647–674 Copyright # Blackwell Munksgaard 2005 Blackwell Munksgaard. Printed in Singapore Journal of Cutaneous Pathology WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects 1 1,2 Abstract: The new WHO/EORTC classification for cutaneous Gu¨ nter Burg , Werner Kempf , lymphomas comprises mature T-cell and natural killer (NK)-cell Antonio Cozzio1, Josef Feit1,3, neoplasms, mature B-cell neoplasms, and immature hematopoietic Rein Willemze4, Elaine S. Jaffe5, malignancies. It reflects the unique features of lymphoproliferative Reinhard Dummer1, Emilio diseases of the skin, and at the same time it is as compatible as possible Berti6, Lorenzo Cerroni7, Sergio with the concepts underlying the WHO classification for nodal Chimenti8, Jose´ L. Diaz-Perez9, lymphomas and the EORTC classification of cutaneous lymphomas. Florent Grange10, Nancy L. This article reviews the histological, phenotypical, and molecular Harris11, Dmitry V. Kazakov12, genetic features of the various nosological entities included in this new Helmut Kerl7, Michael Kurrer13, classification. These findings always have to be interpreted in the Robert Knobler14, Chris J.L.M. context of the clinical features and biologic behavior. Meijer15, Nicola Pimpinelli16, Aim: To review the histological, phenotypical and molecular genetic Elisabeth Ralfkiaer17, Robin features of the various nosological entities of the new WHO/EORTC Russell-Jones18, Christian classification for cutaneous lymphomas. Sander19, Marco Santucci20, Methods: Extensive review of the literature cited in Medline and own Wolfram Sterry21, Steven H. data of the authors. Swerdlow22, Maarten H. Results: The WHO/EORTC classification of cutaneous lymphomas Vermeer4, Janine Wechsler23 comprises mature T-cell and NK-cell neoplasms, mature B-cell and Sean Whittaker18 neoplasms and immature hematopoietic malignancies.
    [Show full text]
  • Primary Pulmonary B-Cell Lymphoma: a Review and Update
    cancers Review Primary Pulmonary B-Cell Lymphoma: A Review and Update Francesca Sanguedolce 1,*,†, Magda Zanelli 2,† , Maurizio Zizzo 3,4 , Alessandra Bisagni 2, Alessandra Soriano 5, Giorgia Cocco 6, Andrea Palicelli 2 , Giacomo Santandrea 2 , Cecilia Caprera 7, Matteo Corsi 7, Giulia Cerrone 7 , Raffaele Sciaccotta 7, Giovanni Martino 7, Linda Ricci 7, Francesco Sollitto 8, Domenico Loizzi 8,‡ and Stefano Ascani 7,‡ 1 Pathology Unit, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, 71122 Foggia, Italy 2 Pathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy; [email protected] (M.Z.); [email protected] (A.B.); [email protected] (A.P.); [email protected] (G.S.) 3 Surgical Oncology Unit, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy; [email protected] 4 Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, 41121 Modena, Italy 5 Gastroenterology, Division and Inflammatory Bowel Disease Center, Department of Internal Medicine, Azienda USL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy; [email protected] 6 Radiotherapy Unit, Azienda Ospedaliero-Universitaria, Ospedali Riuniti di Foggia, 71122 Foggia, Italy; [email protected] 7 Pathology Unit, Azienda Ospedaliera S. Maria di Terni, University of Perugia, 05100 Terni, Italy; [email protected] (C.C.); [email protected] (M.C.); [email protected] (G.C.); [email protected] (R.S.); [email protected] (G.M.); [email protected] (L.R.); [email protected] (S.A.) 8 Institute of Thoracic Surgery, University of Foggia, 71122 Foggia, Italy; [email protected] (F.S.); [email protected] (D.L.) Citation: Sanguedolce, F.; Zanelli, * Correspondence: [email protected]; Tel.: +39-0881-736315 M.; Zizzo, M.; Bisagni, A.; Soriano, A.; † These authors contributed equally to this work.
    [Show full text]
  • Autologous Hematopoietic Stem Cell Transplantation for Intravascular Large B-Cell Lymphoma: the European Society for Blood and Marrow Transplantation Experience
    Bone Marrow Transplantation (2017) 52, 650–652 © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0268-3369/17 www.nature.com/bmt LETTER TO THE EDITOR Autologous hematopoietic stem cell transplantation for intravascular large B-cell lymphoma: the European Society for Blood and Marrow Transplantation experience Bone Marrow Transplantation (2017) 52, 650–652; doi:10.1038/ hematopoietic stem cell transplantation (autoHSCT) has been – bmt.2016.339; published online 19 December 2016 reported to result in a more favorable outcome in single cases7 14 and small case series, almost exclusively in patients of Asian origin (Supplementary Material). In detail, in the pre-rituximab era, two 5 4 Intravascular lymphomas are rare lymphoproliferative disorders out of four and five out of seven autografted patients with IVLBCL were described to survive without relapse. After introduc- characterized by the selective growth of malignant lymphoid cells 6 15 within the lumina of small vessels. On histological and immuno- tion of rituximab, seven out of seven and six out of six patients histochemical examination, around 90% of reported cases meet have been reported to remain alive and relapse-free after 1 autoHSCT. the criteria of large B-cell lymphoma and are categorized into a fi distinct entity in the WHO classification under the designation The objective of the present study was to analyze for the rst time the efficacy of autoHSCT for IVLBCL in a larger cohort of intravascular large B-cell lymphoma (IVLBCL).2 Although IVLBCL Western patients in the rituximab era. can involve extranodal sites in virtually any organ, skin and central This was a registry-based retrospective multicenter study nervous system are predilection sites in Western countries, including patients aged 18 years or over with histologically whereas Asian patients more often present with involvement of fi 1,3,4 veri ed IVLBCL who underwent autoHSCT between 1 January bone marrow, liver and spleen.
    [Show full text]
  • Review Histopathology, Pathogenesis and Molecular Genetics in Primary
    Histol Histopathol (2004) 19: 211-219 Histology and http://www.hh.um.es Histopathology Cellular and Molecular Biology Review Histopathology, pathogenesis and molecular genetics in primary central nervous system lymphomas M. Nakamura, K. Shimada, E. Ishida and N. Konishi Department of Pathology, Nara Medical University, Nara, Japan Summary. Recent increases in the incidence of primary or lymphatics within the nervous system, however, the central nervous system lymphoma (PCNSL), a rare non- pathogenesis and histogenetic origin of PCNSL in Hodgkin’s lymphoma arising in the brain, have been immunocompetent patients is still poorly understood noted in both immunodeficient and immunocompetent regardless of the phenotypic similarities between CNS patients. Compared with lymphomas originating outside and non-CNS lymphomas. the central nervous system, the biology of PCNSL at the molecular or cytogenetic level has not been well Epidemiology characterized, yet it is important to thoroughly understand the etiology of this rare malignant lymphoma The incidence of PCNSL has been increasing if effective therapies are to be developed. This review steadily since the 1970s. Data from the Surveillance, will focus on the epidemiology, clinical aspects, Epidemiology and End Results (SEER) database of the histopathology, pathogenesis, and molecular genetics of National Cancer Institute show that PCNSL increased this aggressive, extranodal lymphoma in more than 10-fold from 0.025/100000 in 1973 to immunocompetent patients. 0.3/100,000 in 1991 and the forecasted incidence for the year 2000 is 0.5/100,000 (Corn et al., 1997). The Key words: Primary central nervous system PCNSL/glioblastoma rate was 1/250 in 1974 and rose to lymphomas, 6q LOH, R-PTP-κ, p14ARF, p16INK4A 1/36 in 1980, reaching 1/6 in 1991 (Eby et al., 1988).
    [Show full text]