DOCSLIB.ORG

Fake News Modern Methods to Identify Counterfeit Medicines and Health Products

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Fake News Modern Methods to Identify Counterfeit Medicines and Health Products February 2019 Volume 32 Number 2 www.chromatographyonline.com Fake News Modern methods to identify counterfeit medicines and health products LC TROUBLESHOOTING GC CONNECTIONS THE ESSENTIALS Reversed-phase LC and water Comprehensive Optimizing sensitivity in GC–FID two-dimensional GC analysis Born to run LCMS-8045 combines speed and robustness under hard conditions Shimadzu’s LCMS-8045 triple quadrupole mass Superior robustness spectrometer complements the company’s ultra- assures long term high sensitivity, even with fast UFMS series and provides high analytical complex biological fluids or food samples throughput. It serves a variety of applications such as veterinary drugs, residual pesticides, Upgradeability water quality analysis and bioanalysis. gives access to world-leading sensitivity and ultra-fast technologies found in the LCMS-8060 Fast polarity switching at 5 msec acquires data in one run, thus reducing total cost per sample and improving throughput Fast scanning speed at 30,000 u/s acquires high qualitative data for compound con firmation as well as high sensitivity quantita- tion in the same analysis www.shimadzu.eu/lcms-8045 LCMS-8045 7 8 9 4 5 6 If your standards and your samples DAWN 1 23 HELEOS-II 0 . TAB ESC DEL are the same size, they must be ENTER the same mass, right? With DAWN you can determine absolute molecular weights and sizes without That’s the problem with calibration-based measuring techniques. You don’t using reference standards made in someone else’s lab. know—you can only assume. Which is why every major pharmaceutical and biotechnology company, as well as most federal regulatory agencies are switching from relative methods to Wyatt Technology’s absolute measure- ments. Our DAWN® multi-angle light scattering (MALS) instruments allow you to determine absolute molecular weights and sizes without relying on so-called standards, or measurements made in someone else’s lab. Wyatt instruments measure all of the quantities required for determining absolute molar masses directly. Learn how to end you dependence on reference standards forever at wyatt.com/NoRef wyatt.com © 2019 Wyatt Technology. All rights reserved. All trademarks and registered trademarks are properties of their respective holders. COVER STORY February | 2019 88 PHARMACEUTICAL PERSPECTIVES The Role of Liquid Chromatography and Gas Chromatography in the Analysis of Illegal Medicines Volume 32 Number 2 and Health Products Yaxin Tie, Celine Vanhee, Erwin Adams, andd EricEric Deconinck This review intends to give a general overview of the liquid chromatographic (LC) and gas chromatographic (GC) methods, utilized by regulatory authorities, for the detection and characterization of suspectedd illegal medicines and health products, including lifesaving drugs, lifestyle drugs, and biotechnology drugs. Features 62 Ultrahigh Resolution Semipreparative Liquid Chromatography: Application to Structure Elucidation of Drug Impurities Fabrice Gritti, Sylvain Cormier, Ronald Morris, Frank Riley, and Qi Yan The performance of a research prototype twin column recycling liquid chromatography (TCRLC) process was investigated regarding the preparation of drug impurities. 94 Analysis Focus: Pharmaceutical Analysis Going Green in Pharmaceutical Analysis Alasdair Matheson LCGC Europe spoke to Yong Liu and Adam Socia from MSD about the cost-saving benefi ts of implementing green chromatography in the pharmaceutical sector, the importance of AMVI, and effective practices to reduce solvent consumption and replace harmful solvents, including SFC, fast chromatography, and “cocktail chromatography”. Columns 72 LC TROUBLESHOOTING Reversed-Phase Liquid Chromatography and Water, Part 1—How Much is Too Much? Dwight Stoll When can we use completely aqueous eluents with reversed-phase stationary phases, and what happens if we make a mistake? 80 GC CONNECTIONS GC×GC: From Research to Routine Nicholas H. Snow This instalment of “GC Connections” begins with a brief introduction to GC×GC, follows with examples of how GC×GC opens additional avenues of analysis, and it concludes with information about how to learn more. 102 THE ESSENTIALS The Essential Guide to Optimizing Sensitivity in GC–FID Editorial Policy: Analysis All articles submitted to LC•GC Europe Tips to improve signal-to-noise ratio when using standard GC are subject to a peer-review process in association equipment with the magazine’s Editorial Advisory Board. Cover: Departments Original materials courtesy: photokozyr/ 97 Products stock.adobe.com 101 Events 56 LC•GC Europe February 2019 A Higher Level of Sensitivity. Every Time. High-purity UHPLC-MS LiChrosolv® solvents for rapid and reliable results. Because our high standards match yours: SigmaAldrich.com/UHPLC-MS © 2018 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved. Merck, the vibrant M, Supelco and LiChrosolv are trademarks of Merck KGaA, Darmstadt, Germany or its affiliates. All other trademarks are the property of their respective owners. Detailed information on trademarks is available via publicly accessible resources. 2018 - 16505 12/2018 The life science business of Merck operates as MilliporeSigma in the U.S. and Canada. Published by UBM Americas Editorial Advisory Board Daniel W. Armstrong Kiyokatsu Jinno University of Texas, Arlington, Texas, USA School of Materials Sciences, Toyohasi Vice President/ Project Manager Günther K. Bonn University of Technology, Japan Group Publisher Vania Oliveira Institute of Analytical Chemistry and Huba Kalász Radiochemistry, University of Innsbruck, Semmelweis University of Medicine, Mike Tessalone [email protected] Austria Budapest, Hungary [email protected] Deirdre Cabooter Hian Kee Lee Digital Production Manager Department of Pharmaceutical and National University of Singapore, Editorial Director Sabina Advani Pharmacological Sciences, University of Singapore Leuven, Belgium Wolfgang Lindner Laura Bush [email protected] Peter Carr Institute of Analytical Chemistry, [email protected] Department of Chemistry, University University of Vienna, Austria Managing Editor Special of Minnesota, Minneapolis, Minnesota, Henk Lingeman Editor-in-Chief Projects USA Faculteit der Scheikunde, Free University, Jean-Pierre Chervet Amsterdam, The Netherlands Alasdair Matheson Kaylynn Chiarello-Ebner Antec Scientific, Zoeterwoude, The Tom Lynch [email protected] kaylynn.chiarello.ebner@ Netherlands Analytical consultant, Newbury, UK ubm.com Jan H. Christensen Ronald E. Majors Managing Editor Department of Plant and Environmental Analytical consultant, West Chester, Kate Jones Art Director Sciences, University of Copenhagen, Pennsylvania, USA Copenhagen, Denmark Debby Mangelings [email protected] Dan Ward Danilo Corradini Department of Analytical Chemistry and [email protected] Istituto di Cromatografia del CNR, Rome, Pharmaceutical Technology, Vrije Associate Editor Italy Universiteit, Brussels, Belgium Lewis Botcherby Subscriber Customer Service Hernan J. Cortes Phillip Marriot H.J. Cortes Consulting, Monash University, School of Chemistry, [email protected] Visit (chromatographyonline.com) Midland, Michigan, USA Victoria, Australia to request or change a Gert Desmet David McCalley Associate Publisher Transport Modelling and Analytical subscription or call our customer Department of Applied Sciences, Oliver Waters Separation Science, Vrije Universiteit, University of West of England, Bristol, UK service department on Brussels, Belgium [email protected] Robert D. McDowall +001 218 740 6877 John W. Dolan McDowall Consulting, Bromley, Kent, UK LC Resources, McMinnville, Oregon, Sales Executive Mary Ellen McNally USA DuPont Crop Protection, Newark, Liz Mclean Hinderton Point, Anthony F. Fell Delaware, USA Pharmaceutical Chemistry, [email protected] Lloyd Drive, Imre Molnár University of Bradford, Bradford, UK Molnar Research Institute, Berlin, Germany Senior Director, Digital Cheshire Oaks, Attila Felinger Luigi Mondello Cheshire, Professor of Chemistry, Department of Dipartimento Farmaco-chimico, Facoltà Media Analytical and Environmental Chemistry, di Farmacia, Università di Messina, Michael Kushner CH65 9HQ, UK University of Pécs, Pécs, Hungary Messina, Italy Tel. +44 (0)151 353 3500 Francesco Gasparrini Peter Myers [email protected] Dipartimento di Studi di Chimica e Fax +44 (0)151 353 3601 Department of Chemistry, Tecnologia delle Sostanze Biologicamente University of Liverpool, Liverpool, UK Webcast Operations Attive, Università “La Sapienza”, Rome, Italy Janusz Pawliszyn Manager Department of Chemistry, University of Joseph L. Glajch Waterloo, Ontario, Canada Kristen Moore Momenta Pharmaceuticals, Cambridge, Massachusetts, USA Colin Poole [email protected] Wayne State University, Detroit, Davy Guillarme Michigan, USA School of Pharmaceutical Sciences, University of Geneva, University of Fred E. Regnier Lausanne, Geneva, Switzerland Department of Biochemistry, Purdue University, West Lafayette, Indiana, USA Jun Haginaka Subscribe on-line at School of Pharmacy and Pharmaceutical Harald Ritchie www.chromatographyonline.com Sciences, Mukogawa Women’s Advanced Materials Technology, Chester, University, Nishinomiya, Japan UK Javier Hernández-Borges Koen Sandra Department of Chemistry Research Institute for Chromatography, Kortrijk, Belgium SUBSCRIPTIONS: LC•GC Europe is free to qualifi ed readers in Europe. (Analytical Chemistry Division), Pat Sandra To apply for a free subscription, or to change your name or address, go to University of La Laguna Research Institute
Load more

Recommended publications
  • Yerevan State Medical University After M. Heratsi
    YEREVAN STATE MEDICAL UNIVERSITY AFTER M. HERATSI DEPARTMENT OF PHARMACY Balasanyan M.G. Zhamharyan A.G. Afrikyan Sh. G. Khachaturyan M.S. Manjikyan A.P. MEDICINAL CHEMISTRY HANDOUT for the 3-rd-year pharmacy students (part 2) YEREVAN 2017 Analgesic Agents Agents that decrease pain are referred to as analgesics or as analgesics. Pain relieving agents are also called antinociceptives. An analgesic may be defined as a drug bringing about insensibility to pain without loss of consciousness. Pain has been classified into the following types: physiological, inflammatory, and neuropathic. Clearly, these all require different approaches to pain management. The three major classes of drugs used to manage pain are opioids, nonsteroidal anti-inflammatory agents, and non opioids with the central analgetic activity. Narcotic analgetics The prototype of opioids is Morphine. Morphine is obtained from opium, which is the partly dried latex from incised unripe capsules of Papaver somniferum. The opium contains a complex mixture of over 20 alkaloids. Two basic types of structures are recognized among the opium alkaloids, the phenanthrene (morphine) type and the benzylisoquinoline (papaverine) type (see structures), of which morphine, codeine, noscapine (narcotine), and papaverine are therapeutically the most important. The principle alkaloid in the mixture, and the one responsible for analgesic activity, is morphine. Morphine is an extremely complex molecule. In view of establish the structure a complicated molecule was to degrade the: compound into simpler molecules that were already known and could be identified. For example, the degradation of morphine with strong base produced methylamine, which established that there was an N-CH3 fragment in the molecule.
    [Show full text]
  • Crowdsourcing Analysis of Off-Label Intervention Usage in Amyotrophic Lateral Sclersosis
    CROWDSOURCING ANALYSIS OF OFF-LABEL INTERVENTION USAGE IN AMYOTROPHIC LATERAL SCLERSOSIS A Thesis Presented to The Academic Faculty by Benjamin I. Mertens In Partial Fulfillment of the Requirements for the Degree B.S. in Biomedical Engineering with the Research Option in the Wallace H. Coulter School of Biomedical Engineering Georgia Institute of Technology Spring 2017 1 ACKNOWLEDGEMENTS I would like to thank my research advisor, Dr. Cassie Mitchell, first and foremost, for helping me through this long process of research, analysis, writing this thesis and the corresponding article to be submitted for peer-reviewed journal publication. There is no way I could have done this, or written it as eloquently without her. Next, I would like to acknowledge Grant Coan, Gloria Bowen, and Nathan Neuhart for all helping me on the road to writing this paper. Lastly, I would like to thank Dr. Lena Ting for her consultation as the faculty reader. 2 TABLE OF CONTENTS Page ACKNOWLEDGEMENTS 2 LIST OF TABLES 4 LIST OF FIGURES 5 LIST OF ABBREVIATIONS 6 SUMMARY 7 CHAPTERS 1 Philosophy 9 2 Crowdsourced Off-label Medications to Extend ALS Disease Duration 12 Introduction 12 Methodology 15 Results 18 Discussion 25 Tables 33 Figures 38 APPENDIX A: All Table 2 Appearance in Patients and Visits 44 APPENDIX B: All Table 3 Appearance in Patients and Visits 114 REFERENCES 129 3 LIST OF TABLES Page Table 1: Database Overview 33 Table 2: Ontology of Individual Medications 34 Table 3: Ontology of Intervention Groups 36 4 LIST OF FIGURES Page Figure 1: Relational circle
    [Show full text]
  • Disposition of T Oxic Drugs and Chemicals
    Disposition of Toxic Drugs and Chemicals in Man, Eleventh Edition Eleventh Edition in Man and Chemicals Drugs Toxic Disposition of The purpose of this work is to present in a single convenient source the current essential information on the disposition of the chemi- cals and drugs most frequently encountered in episodes of human poisoning. The data included relate to the body fluid concentrations of substances in normal or therapeutic situations, concentrations in fluids and tissues in instances of toxicity and the known metabolic fate of these substances in man. Brief mention is made of specific analytical procedures that are applicable to the determination of each substance and its active metabolites in biological specimens. It is expected that such information will be of particular interest and use to toxicologists, pharmacologists, clinical chemists and clinicians who have need either to conduct an analytical search for these materials in specimens of human origin or to interpret 30 Amberwood Parkway analytical data resulting from such a search. Ashland, OH 44805 by Randall C. Baselt, Ph.D. Former Director, Chemical Toxicology Institute Bookmasters Foster City, California HARD BOUND, 7” x 10”, 2500 pp., 2017 ISBN 978-0-692-77499-1 USA Reviewer Comments on the Tenth Edition “...equally useful for clinical scientists and poison information centers and others engaged in practice and research involving drugs.” Y. Caplan, J. Anal. Tox. “...continues to be an invaluable and essential resource for the forensic toxicologist and pathologist.” D. Fuller, SOFT ToxTalk “...has become an essential reference book in many laboratories that deal with clinical or forensic cases of poisoning.” M.
    [Show full text]
  • Le Baclofène Et L'alcool 3 Nouveaux Paradigmes
    Académie Nationale de Pharmacie Lien d’intérêt : Ethypharm/Lundbeck 04/06/2014 Pr P.Jaury Université Paris Descartes 1 Les 3 nouveaux paradigmes proposés: l’abstinence totale ne serait plus nécessaire pour traiter les problèmes d’alcoolisme. « L’abstinence ,n’est plus un objectif mais une conséquence du traitement ». On pourrait soigner efficacement les patients non dépendants ayant un problème d’alcool. On pourrait obtenir « l’indifférence à l’alcool ». 04/06/2014 Pr P.Jaury Université Paris Descartes 2 LE BACLOFENE (AMM) Lioresal®: 1972. AMM : -contractures spastiques de la SEP. -contractures spastiques des affections médullaires (d'étiologie infectieuse, dégénérative, traumatique, néoplasique). -contractures spastiques d'origine cérébrale. -maximum 75 mg par jour en ambulatoire. 04/06/2014 Pr P.Jaury Université Paris Descartes 3 LE BACLOFENE et son action il augmente l’activité GABA (agoniste des récepteurs GABA b) et diminue celle du glutamate. Ce qui réduirait l’activité de la dopamine. Et donc action sur les mécanismes cérébraux de la récompense? 04/06/2014 Pr P.Jaury Université Paris Descartes 4 Médicaments et récepteurs GABA Les benzodiazépines, les barbituriques, le topiramate (Epitomax®), la gabapentine (Neurontin®), la prégabaline (Lyrica®) et les valproates (Dépamide®, Dépakine® et Dépakote®) agissent sur les récepteurs GABA a. Ainsi que l’acamprosate (Aotal ®). Les autres substances connues agissant sur les récepteurs GABA b sont le gamma- hydroxybutyrate ou GHB (Alcover® en Italie et en Autriche dans le traitement de l’alcoolisme en première intention) , le Phénibut® et le Picamilon® en Russie. 04/06/2014 5 Pr P.Jaury Université Paris Descartes LE BACLOFENE et la cocaïne À la dose de 5mg/kg, le baclofène réduit l’auto-administration de cocaïne chez le rat.
    [Show full text]
  • The Efficacy and Safety of Six-Weeks of Pre-Workout Supplementation in Resistance Trained Rats
    W&M ScholarWorks Undergraduate Honors Theses Theses, Dissertations, & Master Projects 4-2017 The Efficacy and Safety of Six-Weeks of Pre-Workout Supplementation in Resistance Trained Rats Justin P. Canakis College of William and Mary Follow this and additional works at: https://scholarworks.wm.edu/honorstheses Part of the Animal Sciences Commons, Exercise Science Commons, Laboratory and Basic Science Research Commons, and the Other Nutrition Commons Recommended Citation Canakis, Justin P., "The Efficacy and Safety of Six-Weeks of Pre-Workout Supplementation in Resistance Trained Rats" (2017). Undergraduate Honors Theses. Paper 1128. https://scholarworks.wm.edu/honorstheses/1128 This Honors Thesis is brought to you for free and open access by the Theses, Dissertations, & Master Projects at W&M ScholarWorks. It has been accepted for inclusion in Undergraduate Honors Theses by an authorized administrator of W&M ScholarWorks. For more information, please contact [email protected]. 1 2 Title Page……………………………………………………………………………………...…..1 Abstract…………………………………………………………………………………………....5 Acknowledgement……………………………………………………………………….………..6 Background.………………………………………………………………………..……………...7 DSEHA and its Effect on the VMS Industry………………...……………………………7 History of Adverse Side Effects from Pre-Workout Supplements ………….……………8 Ingredient Analysis ………………………………………..……………….……………..……....9 2.5g Beta-Alanine…………………………..……………………………………………..9 1g Creatine Nitrate……………………………...……………………………………..…12 500mg L-Leucine……………………………………………………………………...…16 500mg Agmatine Sulfate……………………….………………………………..………18
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9.066,853 B2 Clay (45) Date of Patent: Jun
    USOO9066853B2 (12) United States Patent (10) Patent No.: US 9.066,853 B2 Clay (45) Date of Patent: Jun. 30, 2015 (54) CLONIDINE COMPOUNDS INA 3.? R 1939: Shashekar et al. BODEGRADABLE FIBER 6,723,741W - 4 B2 4/2004 Jeonawinney et al. 6,756,058 B2 6/2004 Brubaker et al. (71) Applicant: Warsaw Orthopedic, Inc., Warsaw, IN 6,773,714 B2 8, 2004 SN al (US) 6,921,541 B2 7/2005 Chasin et al. 6,974.462 B2 12/2005 Sater (72) Inventor: Danielle L. Clay, Collierville, TN (US) 7,166.5707,144,412 B2 12/20061/2007 Wolfetal.Hunter et al. 7,220.281 B2 5/2007 Lambrecht et al. (73) Assignee: Warsaw Orthopedic, Inc., Warsaw, IN 7,229,441 B2 6, 2007 E. t e (US) 7,235,043 B2 6/2007 Gellman et al. 7,287,983 B2 10/2007 Ilan (*) Notice: Subject to any disclaimer, the term of this 2. g E: 3. My patent is extended or adjusted under 35 7361, 168 B2 4/2008 Miiver et al. U.S.C. 154(b) by 0 days. 7,367,978 B2 5/2008 Drewry et al. 7,875,054 B2 * 1/2011 LaFontaine ................... 606,213 (21) Appl. No.: 13/741,475 8, 158,143 B2 * 4/2012 Lendlein et al. .............. 424/426 2002fOOO9454 A1 1/2002 Boone et al. 2002/0090398 A1 7/2002 Dunn et al. (22) Filed: Jan. 15, 2013 2002/0183855 A1 12/2002 Yamamoto et al. ........ 623/23.51 2003. O144570 A1* 7, 2003 Hunter et al. ...... (65) Prior Publication Data 2003/0153972 A1* 8, 2003 Helmus .......................
    [Show full text]
  • Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders
    Int. J. Biol. Sci. 2018, Vol. 14 341 Ivyspring International Publisher International Journal of Biological Sciences 2018; 14(3): 341-357. doi: 10.7150/ijbs.23247 Review Role of Plant Derived Alkaloids and Their Mechanism in Neurodegenerative Disorders Ghulam Hussain1,3, Azhar Rasul4,5, Haseeb Anwar3, Nimra Aziz3, Aroona Razzaq3, Wei Wei1,2, Muhammad Ali4, Jiang Li2, Xiaomeng Li1 1. The Key Laboratory of Molecular Epigenetics of MOE, Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, China 2. Dental Hospital, Jilin University, Changchun 130021, China 3. Department of Physiology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan 4. Department of Zoology, Faculty of Life Sciences, Government College University, Faisalabad, 38000 Pakistan 5. Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science. 2-1 Hirosawa, Wako, Saitama 351-0198 Japan Corresponding authors: Professor Xiaomeng Li, The Key Laboratory of Molecular Epigenetics of Ministry of Education, Institute of Genetics and Cytology, Northeast Normal University, 5268 People's Street, Changchun, Jilin 130024, P.R. China. E-mail: [email protected] Tel: +86 186 86531019; Fax: +86 431 85579335 or Professor Jiang Li, Department of Prosthodontics, Dental Hospital, Jilin University, 1500 Tsinghua Road, Changchun, Jilin 130021, P.R. China. E-mail: [email protected] © Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. Received: 2017.10.09; Accepted: 2017.12.18; Published: 2018.03.09 Abstract Neurodegenerative diseases are conventionally demarcated as disorders with selective loss of neurons.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2015/0290181 A1 Lee Et Al
    US 201502901 81A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0290181 A1 Lee et al. (43) Pub. Date: Oct. 15, 2015 (54) COMBINATION OF EFFECTIVE (52) U.S. Cl. SUBSTANCES CAUSING SYNERGISTIC CPC ............. A6 IK3I/445 (2013.01); A61 K3I/I66 EFFECTS OF MULTIPLE TARGETING AND (2013.01); A61 K3I/505 (2013.01); A61 K USE THEREOF 36/38 (2013.01); A61K 45/06 (2013.01); A61 K 36/744 (2013.01); A61K 36/69 (2013.01); (75) Inventors: Doo Hyun Lee, Seoul (KR); Sunyoung A61K 31/198 (2013.01); A61K 36/40 Cho, Gyeonggi-do (KR) (2013.01); A61 K36/884 (2013.01) (73) Assignee: VIVOZONE, INC., Seoul (KR) (57) ABSTRACT Disclosed are a combination of active components inducing (21) Appl. No.: 14/128,616 synergistic effects of multi-targeting and a use thereof. More particularly, disclosed are a functional food composition, a (22) PCT Filed: Jun. 28, 2012 cosmetic composition, a pain-suppressive composition, and a composition for treatment or prevention of pruritus or atopic (86). PCT No.: PCT/KR2O12/OOS145 dermatitis, which comprise as active components, two or S371 (c)(1), more components selected from a group consisting of (a) a (2), (4) Date: Jan. 16, 2014 5-hydroxytryptamine subtype 2 (5-HT2) receptor antagonist; (b) a P2X receptor antagonist; and (c) any one of a glycine (30) Foreign Application Priority Data receptor agonist, a glycine transporter (GlyT) antagonist, a gamma-aminobutyric acid (GABA) receptor agonist, and a Jun. 28, 2011 (KR) ........................ 10-2011-0063.289 GABA transporter 1 (GAT1) antagonist. The multi-targeting composite composition (specifically, natural Substances com Publication Classification posite composition) has synergistic effects, and thus a treat ment using a combination of respective components may (51) Int.
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley Et Al
    US 2014O144429A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley et al. (43) Pub. Date: May 29, 2014 (54) METHODS AND DEVICES FOR COMPOUND (60) Provisional application No. 61/887,045, filed on Oct. DELIVERY 4, 2013, provisional application No. 61/831,992, filed on Jun. 6, 2013, provisional application No. 61/794, (71) Applicant: E-NICOTINE TECHNOLOGY, INC., 601, filed on Mar. 15, 2013, provisional application Draper, UT (US) No. 61/730,738, filed on Nov. 28, 2012. (72) Inventors: Martin Wensley, Los Gatos, CA (US); Publication Classification Michael Hufford, Chapel Hill, NC (US); Jeffrey Williams, Draper, UT (51) Int. Cl. (US); Peter Lloyd, Walnut Creek, CA A6M II/04 (2006.01) (US) (52) U.S. Cl. CPC ................................... A6M II/04 (2013.O1 (73) Assignee: E-NICOTINE TECHNOLOGY, INC., ( ) Draper, UT (US) USPC ..................................................... 128/200.14 (21) Appl. No.: 14/168,338 (57) ABSTRACT 1-1. Provided herein are methods, devices, systems, and computer (22) Filed: Jan. 30, 2014 readable medium for delivering one or more compounds to a O O Subject. Also described herein are methods, devices, systems, Related U.S. Application Data and computer readable medium for transitioning a Smoker to (63) Continuation of application No. PCT/US 13/72426, an electronic nicotine delivery device and for Smoking or filed on Nov. 27, 2013. nicotine cessation. Patent Application Publication May 29, 2014 Sheet 1 of 26 US 2014/O144429 A1 FIG. 2A 204 -1 2O6 Patent Application Publication May 29, 2014 Sheet 2 of 26 US 2014/O144429 A1 Area liquid is vaporized Electrical Connection Agent O s 2.
    [Show full text]
  • World of Cognitive Enhancers
    ORIGINAL RESEARCH published: 11 September 2020 doi: 10.3389/fpsyt.2020.546796 The Psychonauts’ World of Cognitive Enhancers Flavia Napoletano 1,2, Fabrizio Schifano 2*, John Martin Corkery 2, Amira Guirguis 2,3, Davide Arillotta 2,4, Caroline Zangani 2,5 and Alessandro Vento 6,7,8 1 Department of Mental Health, Homerton University Hospital, East London Foundation Trust, London, United Kingdom, 2 Psychopharmacology, Drug Misuse, and Novel Psychoactive Substances Research Unit, School of Life and Medical Sciences, University of Hertfordshire, Hatfield, United Kingdom, 3 Swansea University Medical School, Institute of Life Sciences 2, Swansea University, Swansea, United Kingdom, 4 Psychiatry Unit, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy, 5 Department of Health Sciences, University of Milan, Milan, Italy, 6 Department of Mental Health, Addictions’ Observatory (ODDPSS), Rome, Italy, 7 Department of Mental Health, Guglielmo Marconi” University, Rome, Italy, 8 Department of Mental Health, ASL Roma 2, Rome, Italy Background: There is growing availability of novel psychoactive substances (NPS), including cognitive enhancers (CEs) which can be used in the treatment of certain mental health disorders. While treating cognitive deficit symptoms in neuropsychiatric or neurodegenerative disorders using CEs might have significant benefits for patients, the increasing recreational use of these substances by healthy individuals raises many clinical, medico-legal, and ethical issues. Moreover, it has become very challenging for clinicians to Edited by: keep up-to-date with CEs currently available as comprehensive official lists do not exist. Simona Pichini, Methods: Using a web crawler (NPSfinder®), the present study aimed at assessing National Institute of Health (ISS), Italy Reviewed by: psychonaut fora/platforms to better understand the online situation regarding CEs.
    [Show full text]
  • Final- Test Database
    This document was exported from Numbers. Each table was converted to an Excel worksheet. All other objects on each Numbers sheet were placed on separate worksheets. Please be aware that formula calculations may differ in Excel. Numbers Sheet Name Numbers Table Name Excel Worksheet Name PARTTESTR1 Table 1 PARTTESTR1 LCMS methods Table 1 LCMS methods UPLC methods Table 1 UPLC methods Test Name Test Type TAT Detection Limit Min. Sample Amnt Method Reference Tags Aerobic Plate Count -- USP Aerobic Plate Count 5 Days <10 cfu/g 10 Grams USP <2021>/GL-411, APC, TAPC Purity Aerobic Plate Count -- FDA BAM Aerobic Plate Count 5 Days <10 cfu/g 10 Grams FDA BAM/GL-410, APC, TAPC Purity Aerobic Plate Count -- AOAC Aerobic Plate Count 5 Days <10 cfu/g 10 Grams AOAC 990.12/GL-412, APC, TAPC Purity Aerobic Plate Count -- EP Aerobic Plate Count 5 Days <10 cfu/g 10 Grams EP Purified Water/GL-391, APC, TAPC Purity Ash Ash 5 Days TBD 10 Grams USP <281>/GL-588 Identity Bacillus cereus Bacillus cereus 5 Days <10 cfu/g 10 Grams GL-483 Purity Bacillus coagulans Bacillus coagulans 5 Days <10 cfu/g 10 Grams GL-471 Purity Bacillus subtilis Bacillus subtilis 5 Days <10 cfu/g 10 Grams Customer Supplied Method Purity Bulk Density Bulk Density 5 Days TBD 10 Grams USP <616>/GL-587 Identity Calories Calories 5 Days TBD 10 Grams USDA Handbook No. 74, pp. 9-11 Potency Calories from Fat Calories 5 Days TBD 10 Grams 21 CFR Part 101.9 (Calc.) Potency Calories from Saturated Fat Calories 5 Days TBD 10 Grams 21 CFR Part 101.9 (Calc.) Potency Carbohydrates Carbohydrates 5 Days TBD 10 Grams Calculation Potency Coliforms -- FDA BAM Coliforms 5 Days <10 cfu/g 10 Grams FDA BAM/GL-422 Purity Coliforms -- AOAC Coliforms 5 Days <10 cfu/g 10 Grams AOAC 991.14/GL-420 Purity Coliforms -- CMMEF Coliforms 5 Days <10 cfu/g 10 Grams CMMEF/GL-391 Purity Density of Solids Density 5 Days TBD 10 Grams USP <699> Identity Mercury (Hg) DMA 5 Days TBD 10 Grams EPA 7473/GL-585 Purity E.
    [Show full text]
  • WO 2014/085719 Al 5 June 2014 (05.06.2014) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/085719 Al 5 June 2014 (05.06.2014) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61M 15/00 (2006.01) A24F 47/00 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/US20 13/072426 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 27 November 2013 (27.1 1.2013) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 61/730,738 28 November 2012 (28. 11.2012) US 61/794,601 15 March 2013 (15.03.2013) US (84) Designated States (unless otherwise indicated, for every 61/83 1,992 6 June 2013 (06.06.2013) us kind of regional protection available): ARIPO (BW, GH, 61/887,045 4 October 201 3 (04.
    [Show full text]