DOCSLIB.ORG

The 44Th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Award Winners

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
The 44Th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Award Winners Bone Marrow Transplantation (2019) 53:13–18 https://doi.org/10.1038/s41409-018-0317-z ABSTRACT The 44th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians Award Winners 18–21 March 2018 ● Lisbon, Portugal Published online: 24 September 2018 © Springer Nature Limited 2018 Copyright: Modified and published with permission from http://www.ebmt2018.org/ Sponsorship Statement: Publication of this supplement is sponsored by the European Society for Blood and Marrow Transplantation. PHYSICIANS AWARD WINNERS in neurologic disability. We now report results on a randomized trial of non-myeloablative HSCT versus 1234567890();,: 1234567890();,: Van Bekkum Award continued treatment with standard DMTs. O001 Methods: Patients on stable disease modifying therapy (DMT) with > 2 relapses in the previous 12 months Non-myeloablative haematopoietic stem cell were randomized (1:1) to treatment with either cyclopho- transplantation versus continued disease modifying sphamide and rabbit anti-thymocyte globulin followed therapies (DMT) in patients with highly active relapsing by hematopoietic stem cell infusion or to a control arm remitting multiple sclerosis (RRMS) with continued treatment with standard DMTs. Evaluating neurologists scoring the Expanded Disability Status Richard K Burt1, Roumen Balabanov2, John A Snowden3, Scale (EDSS) were blinded to treatment arms. Patients Basil Sharrack4, Maria Carolina Oliveira5, Flavia Nelson6, in the control arm who had 6 month confirmed EDSS Joachim Burman7 increase of > 1 point despite at least one year of treatment 1Northwestern University, Division of Immunotherapy for (defined as treatment failure) were allowed to crossover Autoimmune Diseases, Chicago, IL, United States; to HSCT. 2Northwestern University, Department of Neurology, Chi- cago, IL, United States; 3Sheffield Teaching Hospitals NHS Results: 110 patients were randomized, 55 to each arm. Foundation Trust, Department of Haematology, Sheffield, Three HSCT patients were withdrawn: two for failing United Kingdom; 4Sheffield Teaching Hospitals NHS enrollment criteria, one for recurrent infections occurring Foundation Trust, Department of Neurology, Sheffield, before transplant. Five control patients were withdrawn United Kingdom; 5University of São Paulo, Department of after soliciting transplants at other centers. All patients Internal Medicine, São Paulo, Brazil; 6University of Texas are at least one-year post enrollment. No deaths occurred Health Science Center at Houston, Department of Neurol- and no CTC grade 4 non-hematopoietic toxicities ogy, Houston, TX, United States; 7Uppsala University, occurred in the transplant arm. DMTs (number of patients) Department of Neuroscience, Uppsala, Sweden used in the control arm were: natalizumab (22), dimethyl fumarate (18), fingolimod (13) interferons (10), glatiramer Background: We previously reported (Journal of the acetate (8), mitoxantrone (5). During the first year American Medical Association, 2015) that non- after enrollment, one relapse occurred on the HSCT myeloablative haematopoietic stem cell transplantation arm versus 39 on the DMT arm (P< 0.001). Mean (HSCT) may be performed safely in patients with multiple EDSS improved from 3.5 to 2.4 after HSCT while it wor- sclerosis and is accompanied by long-term improvement sened from 3.3 to 3.9 on DMTs (P< 0.001). With a 14 mean follow up of 3 years (range 1 to 5 years), treatment (NTA). VEs stained with Vibrant Dil were incubated with failure was 60% (30 of 50) for the control arm and 6% CD34+ cells from cord blood for 24 hours. Then their (3 of 52) for HSCT (P < 0.001). For the 30 patients incorporation into HPC was analyzed by flow cytometry who failed the control arm and crossed over to HSCT, by and confocal microscopy. To study gene expression chan- one year after HSCT, the mean EDSS improved from 5.2 ges elicited in HPC after MSC-EVs incorporation, expres- to 2.6 (P< 0.001). sion arrays were performed using the Human Gene 2.0ST platform (Affymetrix), evaluating the functions of the Conclusions: HSCT was statistically superior to continued involved genes with the Webgestalt software. Apoptosis DMTs in patients with RRMS with > 2 relapses a year was evaluated by flow cytometry using annexinV/7AAD staining, whereas cell cycle was analyzed with BD Cycle- Clinical Trial Registry: NCT00273364, https://clinicaltria testPlus DNA Reagent kit. In addition, clonal growth of ls.gov/ct2/show/NCT00273364?term=NCT00273364&ra HPCs was compared by clonogenic assays in methylcellu- nk=1 lose. Finally, the functional in vivo changes induced by MSC-EV incorporation were studied in a xenotransplanta- Conflict of interest: All the authors have nothing to tion animal model. For this purpose, control HPC or HPC disclose previously co-cultured with MSC-VEs were administered into the BM of NOD-SCID mice. After four weeks, human hematopoietic engraftment was determined by flow Basic Science Award cytometry. O002 Results: MSC-VEs were positive for both MSC (CD44, CD90) and VEs (CD81, CD63) markers and negative The incorporation of extracellular vesicles from for hematopoietic markers (CD34, CD45), and exhibited mesenchymal stromal cells into hematopoetic progenitors their characteristic morphology by electron microcopy increase their clonogenic capacity and their engraftment and a regular size between 50 and 200nm by NTA. ability The incorporation of EVs into HPC was verified both by confocal microscopy and flow cytometry. In the Silvia Preciado, Sandra Muntión, Ana Rico, Luis Antonio gene expression array analysis we found that MSC- Corchete, Ana Gómez de la Torre, Teresa L Ramos, Con- EV incorporation induced an overexpression of some cepción Rodríguez, Rebeca Ortega, Jorge Diego Rufino, anti-apoptotic genes (BIRC2, BIRC3, NFKB) and a Miriam López-Parra, Alba Redondo, Lika Osugui, Fermín downregulation of pro-apoptotic genes (caspases) with Sánchez-Guijo an overexpression of genes involved in colony formation Hospital Universitario de Salamanca, Salamanca, Spain and hematopoetic cell proliferation (CD22, IL3RA, IL11), together with an activation of genes of the JAK-STAT Background: Treatment of graft failure after bone marrow pathway and an overexpression of CD44. All these (BM) transplantation with mesenchymal stromal cells findings were confirmed by other methods at the gene (MSC) is being evaluated clinically, since preclinical or protein level. A significant decrease in apoptosis evidence shows that MSC co-transplantation increases (p = 0.031), an increase of the percentage of cells in phase S hematopoietic progenitor cell (HPC) engraftment in xeno- (p = 0.065) and an increased CD44 expression (p = 0.03) trasplantation models. Since MSC exert their functions, were confirmed by flow cytometry in HPC that had in part, by the release of extracellular vesicles (EVs), in incorporated MSC-EVs compared to control HPCs. In the current study we wanted firstly to analyze multi- addition, these HPCs displayed a higher CFU-GM clono- parametrically changes induced in HPCs after the incor- genic potential. Finally, in the xenotransplantation poration of EVs released from MSC (MSC-EVs) and model, the engraftment ability of human HPC co-cultured secondly compare their capacity of engraftment in vivo to with MSC-EVs was significantly higher 4 weeks that of control HPC. after transplantation (10.26% (0.31%–71.06%) vs 1.22% (0.15%–55.97%); p = 0.0078). Methods: BM-MSC were isolated from 10 healthy donors following standard methods and characterized following Conclusions: The incorporation of EVs derived from MSC ISCT criteria. MSC-EVs were isolated by ultracentrifuga- induces genomic and functional changes in HPC, increasing tion and characterized by flow cytometry, Western blot, their clonogenic capacity in vitro and their engraftment electron microscopy and nanoparticle tracking analysis ability in vivo. The 44th Annual Meeting of the European Society for Blood and Marrow. 15 Funding: GRS1348/A/16, PI12/01775 (ISCIII, Spain). Results: WES yielded a uniform and consistent coverage of Santander-USAL grant to SP all samples, with an average depth-of-sequencing of 120x for purified AML samples and 60X for donor and patient Conflict of interest: There is no conflict of interest. The germline controls. A total of 249 protein-damaging somatic authors declare no competing financial interests. mutations in 220 genes were detected among all leukemic samples, averaging 15 somatic mutations per sample. Of all mutations, 54 were exclusive to relapses, with the muta- Presidential Symposium tional burden increasing significantly from pre- to post- alloHSCT samples (Wilcoxon test, pvalue = 0.02). This O003 was reflected also by patterns of clonal evolution observed in our cohort, with emergence in 8 patients of new clones at Abstract previously published relapse. Of notice, both number of post-transplantation relapse-specific mutations and appearance of new clones O004 had a tendency to increase proportionally with time to relapse. Relapse-specific mutations encompassed known Genomic and Transcriptional Profiling of Acute Myeloid AML driver genes, including WT1 and KRAS, but no gene Leukemia by Next-Generation Sequencing Unravels evidently related to immune function. Patient-Specific Patterns of Post-Transplantation Relapse By a linear model analysis of RNA-Seq data we found ~500 genes significantly deregulated in leukemic cells at Lucia Zanotti1, Gabriele Bucci1,2, Francesco Santaniello1,2, post-transplantation relapse and, in stark contrast to the Cristina Toffalori1, Donatella Biancolini2,
Load more

Recommended publications
  • GWG-Reappointment Bios
    Agenda Item # 12 6/22-3/11 ICOC Meeting Reappointment of Grants Working Group Scientific Members with Expiring Terms Scientific members of the Grants Working Group (GWG) are normally appointed for a period of six years. The original cohort of scientific members was appointed in May and June of 2005 and therefore their terms are now expiring. Since their original appointment, some of the original members have resigned their appointment from the GWG due to various reasons including other competing commitments. Dr. Alan Trounson and CIRM recommend the reappointment of the following members for an additional 6 year term based on their ongoing participation in CIRM reviews, their distinguished status in the stem cell field, continued interest in serving, and CIRM’s need for their review expertise. Susan Bonner-Weir, Ph.D. Dr. Bonner-Weir is Senior Investigator at the Joslin Diabetes Center and Professor of Medicine at Harvard Medical School in Boston. She received her B.A. degree from Rice University and a Ph.D. in biology from Case Western Reserve University. She then completed postdoctoral training in islet morphology at Harvard Medical School and Joslin. Research in her laboratory concerns the growth and differentiation of the insulin producing pancreatic beta cells. For over twenty-five years Dr. Bonner-Weir has focused on the endocrine pancreas (the islets of Langerhans) in three areas: 1) the architecture of the islet and its implications for function; 2) the in vivo regulation of beta-cell mass; and 3) the factors involved in islet growth and differentiation. Her focus now is how to make a reliable source of new beta-cells.
    [Show full text]
  • CIBMTR Scientific Working Committee Research Portfolio July 1, 2018
    CIBMTR Scientific July 1, Working Committee 2018 Research Portfolio Milwaukee Campus Minneapolis Campus Medical College of Wisconsin National Marrow Donor Program/ 9200 W Wisconsin Ave, Suite Be The Match – 500 N 5th St C5500 Minneapolis, MN 55401-9959 USA Milwaukee, WI 53226 USA (763) 406-5800 (414) 805-0700 cibmtr.org CIBMTR Scientific Working Committee Research Portfolio: July 1, 2018 TABLE OF CONTENTS 1.0 OVERVIEW .................................................................................................................................................................. 1 1.1 Membership ........................................................................................................................................................... 2 1.2 Leadership .............................................................................................................................................................. 2 1.3 Productivity ............................................................................................................................................................ 3 1.4 How to Get Involved ............................................................................................................................................ 3 2.0 ACUTE LEUKEMIA WORKING COMMITTEE .................................................................................................. 6 2.1 Leadership .............................................................................................................................................................
    [Show full text]
  • Spain, France and Italy Are to Exchange Organs for Donation Chains
    Translation of an article published in the Spanish newspaper ABC on 10 October 2012 O.J.D.: 201504 Date: 10/10/2012 E.G.M.: 641000 Section: SOCIETY Pages: 38, 39 ----------------------------------------------------------------------------------------------------------------- This is what happened in Spain’s first ‘crossover’ transplant [For diagram see original article] Altruistic donor The chain started with the kidney donation from a ‘good Samaritan’ going to a recipient in a couple. The wife of the first recipient donated her kidney to a sick person in a second couple. The wife of the second recipient donated her kidney to a third patient on the waiting list. On the waiting list The final recipient, selected using medical criteria, was on the waiting list to receive a kidney from a deceased donor for three years. Spain, France and Italy are to exchange organs for donation chains ► The creation of this type of ‘common area’ in southern Europe will increase the chances of finding a donor match CRISTINA GARRIDO BRUSSELS | Stronger together. Although there are many things on which we find it difficult to agree, this time the strategy was clear. Spain, France and Italy have signed the Southern Europe Transplant Alliance to promote their successful donation and transplant system – which is public, coordinated and directly answerable to the Ministries of Health, as compared to the private models of central and northern Europe – to the international bodies. ‘We (Spain, France and Italy) decided that we had to do something together because we have similar philosophies, ethical criteria and structures and we could not each go our own way given how things are in the northern countries’, explained Dr Rafael Matesanz, Director of the Spanish National Transplant Organisation, at the seminar on donations and transplants organised by the European Commission in Brussels yesterday.
    [Show full text]
  • ©Ferrata Storti Foundation
    Haematologica 2000; 85:839-847 Transplantation & Cell Therapy original paper Allogeneic transplantation of G-CSF mobilized peripheral blood stem cells from unrelated donors: a retrospective analysis. MARTIN BORNHÄUSER,* CATRIN THEUSER,* SILKE SOUCEK,* KRISTINA HÖLIG,* THOMAS KLINGEBIEL,° WOLFGANG BLAU,# ALEXANDER FAUSER,# VOLKER RUNDE,@ WOLFGANG SCHWINGER,^ CLAUDIA RUTT,§ GERHARD EHNINGER* *Medizinische Klinik I, Universitätsklinikum Carl Gustav Carus, Dresden; °Kinderklinik Eberhard Karls Universität, Tübin- gen; #Klinik für Knochenmarktransplantation, Idar-Oberstein. @Klinik für Knochenmarktransplantation, Essen; ^Univer- sitätskinderklinik, Graz, Austria for the §Deutsche Knochenmarkspenderdatei, Tübingen (DKMS), Germany ABSTRACT Background and Objectives. Allogeneic peripheral either unmanipulated or CD34 selected. Prospective blood stem cell transplantation (PBSCT) from studies comparing BMT with PBSCT from unrelated matched siblings has lead to clinical results compa- donors are needed in defined disease categories. rable to those of standard bone marrow transplan- ©2000 Ferrata Storti Foundation tation (BMT). We report the outcome of 79 patients transplanted with PBSC from unrelated donors. Key words: allogeneic transplantation, peripheral blood stem Design and Methods. In 61 cases PBSC were used cells, unrelated donor for primary transplantation whereas 18 patients were treated for relapse or graft-failure. In 35 patients receiving primary transplants, T-cell deple- here are several reports on the outcome of tion (TCD) using CD34
    [Show full text]
  • 39Th Annual Meeting
    Thank you to the 2013 ASHI Corporate Supporters Abbott Molecular Art Robbins Instruments Bio-Rad Laboratories DiaSorin, Inc. Elsevier GenDx Histogenetics Immucor Life Technologies Linkage Biosciences Inc. MLC Group, LLC mTilda HLA Software Specialists National Marrow Donor Program Olerup, Inc. Omixon Biocomputing One Lambda Inc., a part of Thermo Fisher Scientific Inc. STEMCELL Technologies Inc. Final Program 3 Table of Contents General Information .....................................5 ASHI Program Planning Committee. 9 Abstract Reviewers. 10 Board of Directors .....................................13 Corporate Supporters ...................................14 Exhibitor Directory. 15 Award Winners .......................................27 Schedule at a Glance ...................................34 Abstracts ...........................................42 Hotel and Exhibit Floor Plans ..............................95 4 Chicago, Illinois • Sheraton Chicago Hotel and Towers • November 17 – 21, 2013 General Information Registration Registration is located on the Lobby Level to the left of the main entrance. Sunday, November 17 Noon – 7:30 PM Monday, November 18 7:00 AM – 4:00 PM Tuesday, November 19 7:30 AM – 6:00 PM Wednesday, November 20 8:00 AM – 6:00 PM Thursday, November 21 8:00 AM – 10:30 AM Speaker Ready Room The Speaker Ready Room is located in Parlor D on the Lobby Level, Level 3. Sunday, November 17 5:00 PM – 7:00 PM Monday, November 18 7:00 AM – 4:00 PM Tuesday, November 19 7:00 AM – 4:30 PM Wednesday, November 20 7:00 AM – 4:30 PM
    [Show full text]
  • Annual Report
    2018 ANNUAL REPORT dkms.de MATHIES BECKER When Mathies was a child, a stem cell transplant saved his life. PAGE 10 > CONTENTS EDITORIAL 4 SPOTLIGHT 2018 More than just a job: We connect people 6 Blood cancer: The figures 9 STORIES Emotional beginnings, tireless research 10 Development of stem cell collections 13 QUALITY AND EFFICIENCY Always on the lookout for the best donor 14 Interview with Professor Thomas Klingebiel: “It’s about finding the best approach” 17 MEDICINE AND RESEARCH In pursuit of a single goal: A cure 18 OUR DONORS Focus on true heroes 22 JOINING FORCES FOR PATIENTS Our motto: Never give up! 28 World Blood Cancer Day 30 GLOBAL COMMITMENT Stem cells for the world 32 HELPERS AND SUPPORTERS Volunteering can save lives 36 FAQs Social media 2018 40 FACTS & FIGURES Financial results 2018 42 About DKMS gGmbH 45 Balance sheet 46 Income statement 48 Risk management 50 Our contributors 52 PUBLICATION DETAILS 53 “We are deeply grateful to everyone who supports our endeavors to reach out to more and more patients with blood cancer. But we still have much more to do. Crucially, we need more young donors.” DR. ELKE NEUJAHR As Chair of the Board of Directors, Elke Neujahr runs DKMS and its various locations in Germany and worldwide. She is convinced that a global network and collaboration with partners are needed to win the fi ght against blood cancer. 4 I ANNUAL REPORT 2018 Dear Reader, In 2018, the desire to support blood cancer patients by providing the life -saving stem cell transplants they need was tremendous again, with more than 600,000 new donors joining our registry in Germany alone.
    [Show full text]
  • Blood Transfusion «Gladios Veteremque Haurite Crurorem,Ut Repleam Vacuas Iuvenali Sanguine Venas!» Publius Ovidius Naso, Metamorphoses, VII – 333
    The gift in donations A bioethical perspective Giovanni Spitale, M.A. Visiting Research Fellow Institute for Medical Ethics and History of Medicine I Ruhr-Universität Bochum INTRODUCTION Methodological approach Bioethics: a participated discipline Philosophy “with a foot on the ground” A self-reflective science 2 The gift in donations. A bioethical perspective HISTORY AND STATUS QUAESTIONIS Historical overview Regulatory framework Current situation Problems and solutions The healing of deacon Giustiniano, Beato Angelico, 1443 saints Cosmas and Damian operate the «black leg miracle». 3 The gift in donations. A bioethical perspective Blood transfusion «Gladios veteremque haurite crurorem,ut repleam vacuas iuvenali sanguine venas!» Publius Ovidius Naso, Metamorphoses, VII – 333 Historical overview Girolamo Cardano describes direct transfusion (De rerum varietate, 1558) William Harvey describes the functioning of the cardiocirculatory system (1628) Jean Denys and Guglielmo Riva experiment direct blood transfusion with random success (1667) 4 The gift in donations. A bioethical perspective Blood transfusion Historical overview William Aveling performs the first clinical direct blood transfusion (1873) Karl Landsteiner discovers the AB0 system (1901) Landsteiner and Alexander Wiener discover the Rh factor (1940) Introduction of the ACD solution – acid, citrate, dextrose (1943) Bellevue Hospital, New York The first photograph of a direct blood transfusion, ca. 1870 5 The gift in donations. A bioethical perspective Blood transfusion
    [Show full text]
  • International Treatment and Testing Resource Guide
    International Treatment and Testing Resource Guide 2013 OUR MISSION To find effective treatments and a cure for Fanconi anemia and to provide education and support services to affected families worldwide. 1801 Willamette Street, Suite 200 Eugene, OR 97401 541-687-4658 Toll Free: 888-FANCONI (inside the US only) Fax: 541-687-0548 www.fanconi.org [email protected] Staff Beverly Mayhew, Executive Director .................................................... [email protected] Teresa Kennedy, Director of Family Support [email protected] Kristi Keller, Bookkeeper and Administrative Assistant [email protected] Kim Larsen, Conference and Publications Coordinator [email protected] To contact the staff by phone: Toll-free, in the US only: 888-FANCONI (888-326-2664) Outside the US: 541-687-4658 Table of Contents US FA Treatment Resources Bone Marrow Failure ..............................................................................................................1 Bone Marrow Donor Registries ............................................................................................11 Cord Blood Registries ...........................................................................................................12 Endocrinology .......................................................................................................................12 Gastroenterology ...................................................................................................................13
    [Show full text]
  • Paid Organ Donations and the Constitutionality of the National Organ Transplant Act John A
    Hastings Constitutional Law Quarterly Volume 40 Article 1 Number 2 Winter 2013 1-1-2013 Paid Organ Donations and the Constitutionality of the National Organ Transplant Act John A. Robertson Follow this and additional works at: https://repository.uchastings.edu/ hastings_constitutional_law_quaterly Part of the Constitutional Law Commons Recommended Citation John A. Robertson, Paid Organ Donations and the Constitutionality of the National Organ Transplant Act, 40 Hastings Const. L.Q. 221 (2013). Available at: https://repository.uchastings.edu/hastings_constitutional_law_quaterly/vol40/iss2/1 This Article is brought to you for free and open access by the Law Journals at UC Hastings Scholarship Repository. It has been accepted for inclusion in Hastings Constitutional Law Quarterly by an authorized editor of UC Hastings Scholarship Repository. For more information, please contact [email protected]. Paid Organ Donations and the Constitutionality of the National Organ Transplant Act by JOHN A. ROBERTSON* I. Introduction Organ transplant is a well-established medical therapy that saves thousands of lives. Yet many people who could survive with transplants die on waiting lists. With ever expanding indications for transplant, the supply of organs will never meet demand.' But many more organ transplants could occur than do. Efforts to increase organ supply have been constant since the advent of allografting organs in the 1960s. Most of these efforts focused on cadaveric sources and led to enactment of brain death statutes, organ donor cards on driver's licenses, required request laws, and the like. Still yielding only about 10,000 transplants a year, the latest move to increase supply has been to retrieve donated organs immediately after cardiac death.
    [Show full text]
  • The Role of Heme Oxygenase-1 in Hematopoietic System and Its
    Cellular and Molecular Life Sciences https://doi.org/10.1007/s00018-021-03803-z Cellular andMolecular Life Sciences REVIEW The role of heme oxygenase‑1 in hematopoietic system and its microenvironment Agata Szade1 · Krzysztof Szade1 · Mahdi Mahdi1 · Alicja Józkowicz1 Received: 13 October 2020 / Revised: 9 February 2021 / Accepted: 24 February 2021 © The Author(s) 2021 Abstract Hematopoietic system transports all necessary nutrients to the whole organism and provides the immunological protection. Blood cells have high turnover, therefore, this system must be dynamically controlled and must have broad regeneration potential. In this review, we summarize how this complex system is regulated by the heme oxygenase-1 (HO-1)—an enzyme, which degrades heme to biliverdin, ferrous ion and carbon monoxide. First, we discuss how HO-1 infuences hematopoietic stem cells (HSC) self-renewal, aging and diferentiation. We also describe a critical role of HO-1 in endothelial cells and mesenchymal stromal cells that constitute the specialized bone marrow niche of HSC. We further discuss the molecular and cellular mechanisms by which HO-1 modulates innate and adaptive immune responses. Finally, we highlight how modulation of HO-1 activity regulates the mobilization of bone marrow hematopoietic cells to peripheral blood. We critically discuss the issue of metalloporphyrins, commonly used pharmacological modulators of HO-1 activity, and raise the issue of their important HO-1-independent activities. Keywords HO-1 · Hmox1 · HSPC · Hematopoiesis · Niche Introduction self-renew over the entire lifetime, what is progressively lost as they diferentiate toward ST-HSC and MPP. MPP diferen- HSC and their niche, hematopoiesis tiate downstream into two types of oligopotent progenitors: common myeloid progenitors (CMP) and common lymphoid Hematopoietic stem cells (HSC) produce all the blood cells progenitors (CLP), where myeloid oligopotent progenitors throughout life in a process called hematopoiesis.
    [Show full text]
  • EBMT-Annual-Report-2019.Pdf
    TABLE OF CONTENTS Foreword by the EBMT President 2 About the European Society for Blood and Marrow Transplantation 3 EBMT structure 4 Staff organisational chart 5 EBMT membership 6 Legal and regulatory activities 8 SCIENCE The scientific activity reports 11 Severe Aplastic Anaemia Working Party (SAAWP) 12 Autoimmune Diseases Working Party (ADWP) 14 Acute Leukaemia Working Party (ALWP) 16 Cellular Therapy & Immunobiology Working Party (CTIWP) 18 Infectious Diseases Working Party (IDWP) 20 Inborn Errors Working Party (IEWP) 22 Lymphoma Working Party (LWP) 24 Paediatric Diseases Working Party (PDWP) 26 EBMT Chronic Malignancies Working Party (CMWP) 28 Transplant Complications Working Party (TCWP) 30 EBMT Publications 2019 32 EBMT Transplant Activity Survey 2018 38 The EBMT Registry 41 EDUCATION EBMT 45th Annual Meeting 45 Awards 48 Educational events 2019 50 New EBMT e-learning platform 51 PATIENT CARE EBMT Nurses Group Activity Report 53 Highlights of the JACIE’s activities 56 Financial Report and Highlights 2019 60 EBMT’s partners 64 Foreword by the EBMT President Nicolaus Kröger EBMT President As president of our society I am very proud and honored to Patient, Family and Donor Day into the congress as well as present the EBMT activity report summarising the amazing the launch of the 1st Transplant Coordinator Day was very well achievements of our society in 2019. received and was based on our strategy to provide patients with a voice in a patient-focused society as well as including In our annual report you can follow the scientific and all health care providers involved in stem cell transplantation educational activities of our working parties and nurses’ and cellular therapies.
    [Show full text]
  • 2012 Hematologic Oncology Annual Report
    Hematologic Oncology 2012 ANNUAL REPORT Contents Letter from the Division Head . 1 Events Hematologic Oncology Team . 2 American Society of Hematology Annual Meeting . 11 Patient Care The Mortimer J . Lacher Fellows Conference . 11 Making Cell-Based Therapies Safer Hematologic Oncology Nurses Represent MSK and More Effective . 4 at National Meetings . 12 Five Facts about Stem Cell Transplantation Stem Cell Transplant Survivors Celebration . 12 and How to Become a Donor . 5 Appointments and Promotions . 13 Patient Story: Clinical Training and Education . 14 A Team Approach to Tackling a Rare Cancer . 6 Fundraising Overview of Centers and Programs . 7 Swim Across America . 15 Expanding Our Program . 7 Stand Up to Cancer Dream Team . 15 Interview with Martin S. Tallman . 8 Fred’s Team . 16 Research Cycle for Survival . 16 Investigators Discover Why Some Leukemia Drugs Publications . 17 Are Not Sufficiently Effective . 9 Philanthropic Donors . 19 Helping the Thymus Bounce Back . 10 You Can Help . 19 ON THE COVER [LEFT] DR. REKHA PARAMESWARAN, MD ASSOCIATE ATTENDING, HEMATOLOGY SERVICE [RIGHT] DR. ROSS LEVINE, MD ASSOCIATE ATTENDING, LEUKEMIA SERVICE Letter from the Division Head The Division of Hematologic Oncology is 2012 Hematologic Oncology Facts and Figures one of the largest programs in the United States dedicated to caring for people with New Visits/ Initial Encounters Follow-Ups Total hematologic cancers. We are also home Outpatient 3,923 35,662 39,585 to the nation’s largest fellowship program Inpatient 1,957 31,300 33,257 for Medical Hematology/Oncology. In 2012, we expanded our clinical program Adult Bone Marrow Transplants (Table I). We recruited three new faculty members and established a new service Allogeneic 157 devoted to Multiple Myeloma.
    [Show full text]