DOCSLIB.ORG

Xjritiih Bteita1 Rournat.I 7 ~THE JOURNAL of the BRITISH MEDICAL ASSOCIATION

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Xjritiih Bteita1 Rournat.I 7 ~THE JOURNAL of the BRITISH MEDICAL ASSOCIATION THE XjritiiH BteiTa1 rOurnat.I 7 ~THE JOURNAL OF THE BRITISH MEDICAL ASSOCIATION. EDITED BY NORMAN GERALD HORNER, M.A., M.D. VOLUME 11, 1934 -JULY TO DECEMBER 11 3iErntIur: PRINTED AND PUBLISHED AT THE OFFICE OF THE BRITISH MEDICAL ASSOCIATION, TAVISTOCK SQUARE, LONDON, W.C.1. I [ THE BRITISR JULY-DEC., 1934] REY TO DATES AND PAGES I MEDICAL JOURNAL KEY TO DATES AND PAGES THE following table, giving a key to the dates of issue and the page numbers of the BRITISH MEDTCAL JOURNAL and SUPPLEMENT in the second volume for 1934, may prove convenient to readers in search of a reference. Serial Date of Journal Supplement No. Issuie Pages Pages 3835 J lily 7th 1- 48 1- 24 3836 14thi 49- 98 25- 36 3837 21st 99- 152 37- 44 3838 28th 153- 192 45- 84 3839 AuLg. 4th 193- 240 85 - 112 3840 11th 241- 290 .113- 124 3841 18th 291- 338 .125 - 148 3842 25th 339- 380 .149- 156 3843 Sept. 1st 381- 454 3844 8th 455- 498 .157- 164 3845 15thl 499- 538 .165 - 168 3846 22nid 539- 578 .169- 172 3847 29th 579- 618 .173- 180 3848 Oct. 6th 619- 664 .181- 192 3849 13th 665- 706 .193- 204 3850 20th 707- 754 .205- 212 3851 27tll 755- 796 .213 - 228 3852 Nov. 3rd 797- 844 .229 - 236 3853 10th 845- 890 .237 - 248 3854 17tl 891- 928 .249 - 260 3855 ,, 24th 929- 976 .261 - 268 3856 Dec. lst 977 - 1026 .269 - 280 3857 8th 1027 - 1086 .281 - 292 3858 15th 1087 - 1136 .293 - 300 3859 22n,d 1137 - 1186 .301 - 304 3860 29th 1187 - 1228 .305- 308 INDEX TiO VOLUMNE I1 F'OR 1934 READERS in search of a particular subject will find it useful to bear in mind that the references are in several cases distributed under two or more separate but nearly synonyrmous headings-such, for instance, as Brain and Cerebral; Heart and Cardiac; Liver and Hepatic; Renal and Kidney; Cancer and Carcinoma, Epithelioma, Malignant Disease, New Growth, Sarcoma, etc.; Child and Infant; Bronchocele, Goitre, and Thyroid; Diabetes, Glycosuria, and Sugar; Light, Roentgen, Radium, X Rays; Status Lymphaticus and Thymus; Eye, Ophthalmia, and Vision; Pyelography and Urography; Lunacy and Mental l)iseases; Sunlight and Ultra-violet; Bicycle and Cycle; Motor and Automobile; Association, Institution, and Society, etc. Subjects dealt witb under various main headings in the JOUR*AL have been set out in alphabetical order under their respective headings-for example, "Auinotations," "Correspondence," "Leading Articles," "Reviews," etc. Original Articles are indicated by the letter (0). For Obituary Notices see under Names of Individuals. A. Adrenaline, after-effects o0 continued doses of, Anaemia and non-sspecific colitis (D. C. Hare), 538 162 (1) ABDERHALDEN, Emil. elected a corresponding Adrenaline, biological properties of(A. C. Marie), Anaemis, nutritional, 122, 526 foreign membet of the Vienna Academyv of 910 Anaemia, pernicious IJ. M. O'Donovan), 1071 Sciences. 337 Adrenaline and cerebral baemorrhage, 578 Anaemia, pernicious, blond films in, convenient Abdominal cyst. See Cyst Adrenaline in haemoptysis, intratracheal in- method of examining (G. H. H. Booth), 17 Abdominal pregnancy. See Pregnancy jections of,1123 Anaemia, pernicious, nature and treatment of AB13RCROMBIxE, Rt. H.: The swab in diphtheria ADRIAN, E. D.: Awarded a Royal Medal of the (leading article), 726 diagnosis, 373 Royal Society, 911-Discoverer of cortical Anaemia, splenic, pathological basis of (J. Aberdeen. See Scotland rhythm. 1129 McMichael), 225 ABERLE, S. B. D.: Vitamin A and nerve lesions, ADSON: The endocrine factor in essential hyper- Anaemia, yesterday and to-day (Francis J. 1053 tension, 261 O'Donnell), 915 Abortion. contagious, discussion on. 483 Advancement and tendon lengthening (W. B. Anaemias of pregnancy (G. D. Kersley and D. A. Abortion, contagious, and undulant fever in Inglis Pollock). 269 Mitchell), 720 (0) Northumberland (A. I. Messer), 856 (0) Aerophagy with meteorism, 843,1136 Anaemias and their treatment (Leslie Witts), ABRAHAMS, Adolphe: Publicity, 699 Africa, East: East African Medical Service, 830-Discussion, 830 ABRAHAmsON, Leonard: Adhesions in artificial information concerning, 447 Anaesthesia, chloroform, in maternity cases, pneumothorax, 790 Africa, South, Union of: Bantus, health of, 1222 ABRAM!, Professor: Rheumatoid arthritis, 127 recommendations of Departmental Com- Anaestbesia, chloroform - hyoscine. in labour Ab,scess, brain, review of book on, 772 mittee, 128-Female nurse aids, 129-Medicel (James Clark), 468 (0). See also Labouir Abscess. epidural spinal, case of (J. Mlintzman), aids, 128-Medical and nursing services in Anaesthesia, closed, with C02 absorption (W. B. 593 (0) the native territories. 128, 612-Public health Primrose), 223, 339 (0)-Discussion, 223-bead- Abscess of frontal lobe, extradermal. Jacksonian in, 479 ing article, 360-Correspondence on. 489 attacks in connexion with (Douglas Y. Richard- Africa, West: West African Medical Service, Anaesthesia, cocaine, firbt operation under, son), 1101 information concerning, 447 commemoration of. 663 Abscess of liver, non-troDical solitary (A. H. Agranulocytic angina (A. Daly Briscoe), 61(0). Anaestbesia, cyclopropane (W. Stanley Sykes', Holmes), 991 185-Correspondence on, 139,185 901 (0) Abscess, peritonsillar, haemorrhage from, 284, Agranulocytic angina in a diphtheria carrier Anaesthesia, deaths following (parliamentary 371, 491, 533, 612,'657 (A. Ford Tredre), 902 note), 926 Agranulocytosis (F. W. Madison and T. L. Anaesthesia, evipan, 40. 141, 201, 224, 285, 312- Squier), 29 {H. J. A. Simmons), 224-Discussion, 221- ACADEMY, ROYAL. OF MEDICINE IN IRELAND: Agriculture, control of poisons in (parliamentary Correspondence on, 285, 322, 534. 656, 700, 706- Election of Fellows, 607 note), 887 On a full stomach, 656, 700. See also Sodium Section of Medicine.-Adhesions in artificial AINsWORTH, Norman J.: Residual infection of evipan pneumothorax, 790-Gee's disease, 918. 1026- the jaws, 834 Anaesthesia, evipan, in ophthalmic surgery A correction, 1026 AINSWORTH, Major-General R. B., appointed (T. Keith Lyle and F. G. Fenton), 589 (0) Section of Obstetrics antd Gynaecology.- Officer of the Order of St. John of Jerusalem, Anaesthesia, intratracheal (R. W. Shaw), 1217 Some personal prejudices, 917 - Operation 24 Anaesthesia in maternity cases. 1015.1128, 1222 masks. 1013-Cervical myoma, 1013 AINSWORTH-DAVIS, J. C. * Chronic cervicitis, Anaesthesia, nitrous oxide and air, in the mid- Section of Pathology.-Growth of B. coli in 935(0)- Diathermy cutting current in cervi- wifery of general and hospital practice (John water, 919 citis, 316, 935 Elam), 1196 (0) Sectionof Surgerv.-Acutecholecystitis.879- Air. compressed, ruDture of the sigmoid from Anaesthesia, personal factors influencing (H. P. The intratracheal method of anaesthesia, (H J. Nightingale), 860 Crampton), 877 1217 Aircraft, control of infection by, in Sudan (par- Anaesthesia, review of books on, 168, 555 liamentary note), 1134 Anaesthesia, spinocain (J. U. A. Norman), 271 Accidents, road. 96, 213. 887-Doctors summoned Air Force, Royal: Information concerning the Anaesthetic explosions from static dischar ge in, 96-Emergency treatment for, 213-Figures, medical branch of the, 'l41-Appointments, 966 887 - Leading article on, 213 - Motor, in the 453-Annual report on the health of for 1933, Anaesthettc, local, for nasal work, 380 United States, 753-Parliamentary notes on. 1110-Sea also Supplement Index Anaesthetic shield for use in mastoid opera- 96,887.1084-Pedal cyclists and, 96-In mines Air, transport of invalids by, 538 tions, 518 and quarries in 1933,1084 Air warfare, disease carriers in (parliamentary Anaquintine nasal drops, 1202 Accidents in sewers: Report, 367 note), 96 Anatomy, review of books on, 18, 118, 861. 992 Acetllcholine bromide, 635 AITKEN, Charles J. Hill: Labour and heart ANDERSON, A. Greig: Organic and functional Aehlorhydria (Arthur F. Hurst), 218, 665 (0) disease, 578-The G. P.'s nightmare, 796- nervous disorders, 267 -Discussion, 218 LabelliDg patients, 1086 ANDERSON, J. Barcrofs: Priapism after circum- Acid child " and rheumatism. See Rheu- AITIEN, McCrae: Pott's paraplegia, 1012 cision, 1025 matism AITREN, Robert: Rodent ulcer in the young, ANDERSON, J. H.: Achlorhydria, 218 Acid extract of anterior pituitary. See Pituitary 1044 ANDREASEN, A. T.: Bilateral rupture of the Aota Cancrologica, first number of. 770 Alcoholic cirrhosis. See Cirrhosis tendon of extensor pollicis longus, 515 .etaBadiologica. Supplementum XIX: Effects ALEXANDER, Browning: Seaside resorts for ANDREWES, C. H.: The mouse and influenza of x rays on the lungs (Rolf Bull Enselstad), respiratory disease, 31 virus, 817 364-No. XIV: The ionization method of ALEXANDER, G. F.: Ocular Dioptrics and Lenses, ANDROss, Mary (and Mary MACKIERDY): Cheap measuring the intensity and absorption of rev., 258 Diets representing a Week's Meals, rev., 20 Roentgen rays (Dr. Thoraeus), 906 Alkali reserve in asthma, 531, 611, 836 Aneurysm, subelavian (left) and cervical rib ADAM, James: Asthma in children, 330-Alkali Alkaline treatment of coryza, 1222 (T. G. Quinn and George Davison), 808 (0) reserve in asthma. 531-Aetiology and treat- ALLEN, Bernard M.: Sir Robert Morant. A Angel of Death," 885 ment of asthma, 1070 Great Public Servanit, rev., 1102 ANGEL'UCCI, Arnardo, deatli of, 335 ADAMs, A. Wilfrid: Pelvic cellulitis of unknown ALLEN, H. W.: Headache following lumbar Angina, agranulocytic (A. Daly Briscoe), 61 (0), origin, 17-Use of fascia lata sutures, 922 puncture. 349 (0) 185-Correspondeace on, 139,185 ADAMs, E. W.: Recepst Researches on the Nature Allergic factors in rbinorrhoea and nasal catarrh Angina, agranulocytic, in a diphtheria carrier and Therapy of Pernicious Anaemia, 726 (Theodore Just), 587 (0) (HX. Ford Tredre), 902 Adaptor, electrioal mains, for diagnostic set, Allergic state (O. C. W. Prausnitz), 960 Angina pectoris, total thyroidectomy in treat- 1048 Allergy, metabolism,and the autonomic nervous ment of (O. Brenner, Hugh Donovan, and Addendum. 152 systeIn C. Paget Fapage). 985 (O)-Correspon- B. L. S. Murtagh). 624 (0) ADDISON, Ro. Hon. Christopher:-Four anid a dence on. 1086 Angina, tobacco, 922 Half Years: A Personal Diary from June. Allergy, review of books on, 812. 1047, 1104 Animal behaviour, study of, 523 1914, tooJanisary, 1919.
Load more

Recommended publications
  • Medlines a Biannual Publication from the College of Medical and Dental Sciences
    Spring/Summer 2012 Medlines A biannual publication from the College of Medical and Dental Sciences Cell therapy at Birmingham Liver unit leads way in new clinical trials Inside this issue: Campaign for antibiotic research; Urine test for cancer; Brain vulnerable to Hepatitis C virus 2 Welcome News in Brief Breast cancer trial results A major UK trial led by the University has produced firm evidence that giving radiotherapy between or during chemotherapy cycles to women with early breast cancer significantly reduces the risk of the cancer recurring in the breast or chest wall. The treatment, known as synchronous chemoradiation, has minimal adverse side- effects and no detrimental effect on patients’ quality of life. Findings from the SEquencing of Chemotherapy and Radiotherapy in Adjuvant Breast cancer (SECRAB) study – which was carried out at 48 centres in the UK and is Welcome the largest study to investigate the treatment – were presented in Stockholm, to delegates The Medical School can trace its history back to 1825; 75 years at the 2011 European Multidisciplinary Cancer Congress. before the University of Birmingham received its Royal Charter. Researchers unite to fight TB A blue plaque by the House of Fraser Dame Hilda Lloyd – a pioneer and role model Academics from the School of Biosciences department store in Birmingham city centre in so many different ways. Our commitment to are joining forces with peers from the Indian marks the original site of the Medical School promoting science and to inspiring the next Institute of Science, Bangalore (IISc) in a new and commemorates its founder, William Sands generation of researchers is endorsed by the research partnership focused on tackling Cox.
    [Show full text]
  • A History of English
    A History of the English Language PAGE Proofs © John bEnjamins PublishinG company 2nd proofs PAGE Proofs © John bEnjamins PublishinG company 2nd proofs A History of the English Language Revised edition Elly van Gelderen Arizona State University John Benjamins Publishing Company Amsterdam PAGE/ Philadelphia Proofs © John bEnjamins PublishinG company 2nd proofs TM The paper used in this publication meets the minimum requirements of 8 the American National Standard for Information Sciences – Permanence of Paper for Printed Library Materials, ansi z39.48-1984. Library of Congress Cataloging-in-Publication Data Gelderen, Elly van. A History of the English Language / Elly van Gelderen. -- Revised edition. p. cm. Includes bibliographical references and index. 1. English language--History. 2. English language--History--Problems, exercises, etc. I. Title. PE1075.G453 2014 420.9--dc23 2014000308 isbn 978 90 272 1208 5 (Hb ; alk. paper) isbn 978 90 272 1209 2 (Pb ; alk. paper) isbn 978 90 272 7043 6 (Eb) © 2014 – John Benjamins B.V. No part of this book may be reproduced in any form, by print, photoprint, microfilm, or any other means, without written permission from the publisher. John Benjamins Publishing Co. · P.O. Box 36224 · 1020 me Amsterdam · The Netherlandspany John Benjamins North America · PP.O. Boxroofs 27519 · Philadelphia pa 19118-0519G com · usa PAGE Publishin Enjamins © John b 2nd proofs Table of contents Preface to the first edition (2006) ix Preface to the revised edition xii Notes to the user and abbreviations xiv List of tables xvi List of figures xix 1 The English language 1 1. The origins and history of English 1 2.
    [Show full text]
  • Former Fellows Biographical Index Part
    Former Fellows of The Royal Society of Edinburgh 1783 – 2002 Biographical Index Part Two ISBN 0 902198 84 X Published July 2006 © The Royal Society of Edinburgh 22-26 George Street, Edinburgh, EH2 2PQ BIOGRAPHICAL INDEX OF FORMER FELLOWS OF THE ROYAL SOCIETY OF EDINBURGH 1783 – 2002 PART II K-Z C D Waterston and A Macmillan Shearer This is a print-out of the biographical index of over 4000 former Fellows of the Royal Society of Edinburgh as held on the Society’s computer system in October 2005. It lists former Fellows from the foundation of the Society in 1783 to October 2002. Most are deceased Fellows up to and including the list given in the RSE Directory 2003 (Session 2002-3) but some former Fellows who left the Society by resignation or were removed from the roll are still living. HISTORY OF THE PROJECT Information on the Fellowship has been kept by the Society in many ways – unpublished sources include Council and Committee Minutes, Card Indices, and correspondence; published sources such as Transactions, Proceedings, Year Books, Billets, Candidates Lists, etc. All have been examined by the compilers, who have found the Minutes, particularly Committee Minutes, to be of variable quality, and it is to be regretted that the Society’s holdings of published billets and candidates lists are incomplete. The late Professor Neil Campbell prepared from these sources a loose-leaf list of some 1500 Ordinary Fellows elected during the Society’s first hundred years. He listed name and forenames, title where applicable and national honours, profession or discipline, position held, some information on membership of the other societies, dates of birth, election to the Society and death or resignation from the Society and reference to a printed biography.
    [Show full text]
  • Enregisterment in Historical Contexts
    0 Enregisterment in Historical Contexts: A Framework Paul Stephen Cooper A thesis submitted to the University of Sheffield for the degree of Doctor of Philosophy in the School of English Literature, Language and Linguistics February 2013 1 ABSTRACT In this thesis I discuss how the phenomena of indexicality and enregisterment (Silverstein 2003; Agha 2003) can be observed and studied in historical contexts via the use of historical textual data. I present a framework for the study of historical enregisterment which compares data from corpora of both nineteenth-century and modern Yorkshire dialect material, and the results of an online survey of current speakers so as to ascertain the validity of the corpus data and to use ‘the present to explain the past’ (Labov 1977:226). This framework allows for the identification of enregistered repertoires of Yorkshire dialect in both the twenty-first and nineteenth centuries. This is achieved by combining elicited metapragmatic judgements and examples of dialect features from the online survey with quantitative frequency analysis of linguistic features from Yorkshire dialect literature and literary dialect (Shorrocks 1996) and qualitative metapragmatic discourse (Johnstone et al 2006) from sources such as dialect dictionaries, dialect grammars, travel writing, and glossaries. I suggest that processes of enregisterment may operate along a continuum and that linguistic features may become ‘deregistered’ as representative of a particular variety; I also suggest that features may become ‘deregistered’ to the point of becoming ‘fossil forms’, which is more closely related to Labov’s (1972) definition of the ultimate fate of a linguistic stereotype. I address the following research questions: 1.
    [Show full text]
  • Bypass Vs. Angioplasty in Severe Ischaemia of the Leg-2
    Multi-centre randomised controlled trial to compare the clinical and cost-effectiveness of a ‘vein bypass first’ with a ‘best endovascular treatment first’ revascularisation strategy for severe limb ischaemia due to infra-popliteal arterial disease Bypass vs. Angioplasty in Severe Ischaemia of the Leg-2 TRIAL PROTOCOL: Version 4.0 26 July 2016 Sponsor: University of Birmingham Chief Investigator: Professor Andrew Bradbury Coordinating Centre: Birmingham Clinical Trials Unit Funder: NIHR Health Technology Assessment programme ISRCTN: 27728689 Main REC Ref. No.: 14/WM/0057 Version 4.0, 26 July 2016 TRIAL COMMITTEES AND CONTACT Trial Management Group Chief Investigator Sampson Gamgee Professor of Vascular Surgery Professor Andrew Bradbury University of Birmingham Email: [email protected] Co-Applicants Southampton: Professor Shearman; Dr Odurny St George’s, London: Mr Hinchliffe; Professor Belli Imperial College, London: Professor Davies; Dr Burfitt Oxford: Mr Perkin; Dr Uberoi Birmingham: Mr Claridge; Dr Ganeshan; Leicester : Professor Naylor; Dr Adair Hull: Professor Chetter; Professor Ettles Leeds: Professor Scott; Dr Patel Sheffield: Professor Beard; Dr Cleveland Newcastle: Professor Stansby; Dr Jackson Scotland: Professor Brittenden; Dr Robertson Birmingham Clinical Trials Unit Director: Jon Deeks Birmingham Clinical Trials Unit, University of Birmingham Email: [email protected] Statistician: Smitaa Patel Birmingham Clinical Trials Unit, University of Birmingham Email: [email protected] Trial Management: Margaret Grant
    [Show full text]
  • Popular Political Oratory and Itinerant Lecturing in Yorkshire and the North East in the Age of Chartism, 1837-60 Janette Lisa M
    Popular political oratory and itinerant lecturing in Yorkshire and the North East in the age of Chartism, 1837-60 Janette Lisa Martin This thesis is submitted for the degree of Doctor of Philosophy The University of York Department of History January 2010 ABSTRACT Itinerant lecturers declaiming upon free trade, Chartism, temperance, or anti- slavery could be heard in market places and halls across the country during the years 1837- 60. The power of the spoken word was such that all major pressure groups employed lecturers and sent them on extensive tours. Print historians tend to overplay the importance of newspapers and tracts in disseminating political ideas and forming public opinion. This thesis demonstrates the importance of older, traditional forms of communication. Inert printed pages were no match for charismatic oratory. Combining personal magnetism, drama and immediacy, the itinerant lecturer was the most effective medium through which to reach those with limited access to books, newspapers or national political culture. Orators crucially united their dispersed audiences in national struggles for reform, fomenting discussion and coalescing political opinion, while railways, the telegraph and expanding press reportage allowed speakers and their arguments to circulate rapidly. Understanding of political oratory and public meetings has been skewed by over- emphasis upon the hustings and high-profile politicians. This has generated two misconceptions: that political meetings were generally rowdy and that a golden age of political oratory was secured only through Gladstone’s legendary stumping tours. However, this thesis argues that, far from being disorderly, public meetings were carefully regulated and controlled offering disenfranchised males a genuine democratic space for political discussion.
    [Show full text]
  • Evaluation on the Effects of Hydrocolloids on Sensory, Texture and Color Properties of Mulberry Pastille
    242 October, 2019 AgricEngInt: CIGR Journal Open access at http://www.cigrjournal.org Vol. 21, No. 3 Evaluation on the effects of hydrocolloids on sensory, texture and color properties of mulberry pastille Nosrat Azimi1, Shadi Basiri2*, Ali Mortazavi3 (1. MSc of Food Science and Technology, Sabzevar Branch, Islamic Azad University; 2. Assistant professor, Agricultural Engineering Research Department , Khorasan Razavi Agricultural and Natural Resources Research Center, AREEO, Mashhad, Iran; 3. Professor, Food Science and Technology Department, Faculty of Agriculture, Ferdowsi University of Mashhad, Iran) Abstract: White mulberry is a fruit with high nutritional quality. The shelf life of Mulberry is short due to high moisture content. In this research, a new product from white Mulberry called pastille was formulated. Two hydrocolloid ingredients: guar (0%, 0.5% and 1%) and gelatin (0%, 1% and 2%) were used for pastille formulations. Parameters such as color parameters (L* a* b*), sensory evaluations and texture profile analysis (TPA) of samples were investigated. The results of texture evaluation showed that springiness, chewiness, adhesiveness and hardness increased by increasing gelatin, while cohesiveness decreased. Hardness and adhesiveness decreased by addition of the guar. Hardness and adhesiveness decreased with adding guar. Sensory evaluation showed that increasing of the hydrocolloids led to the decrease of acceptability scores. The parameters of a* and b* of pastille samples increased with increasing hydrocolloids concentration, however L* values decreased when the amount of hydrocolloids increased. Mulberry pastille including 1% guar and 1% gelatin having the lowest amount of hardness, adhesiveness, chewiness and suitable color characteristics, was determined as the best formulation among the other investigated samples.
    [Show full text]
  • Celebrating the Rich History of Waxes Bladel, the Netherlands What’S Inside: Watertown, Connecticut, Usa
    CELEBRATING THE RICH HISTORY OF WAXES BLADEL, THE NETHERLANDS WHAT’S INSIDE: WATERTOWN, CONNECTICUT, USA 2-3 – HERITAGE 4-5 – INNOVATION 6-7 – WORLD RESOURCES 8-9 – NATURAL/ORGANIC 10-11 – SILICONYL WAXES 12-13 – CUSTOM BLENDS 14-15 – EMULSIFYING WAXES 16-17 – KESTER WAXES 18-19 – MILKS 20-41 – WAX SPECIFICATIONS 42 – WAX PROPERTIES KOSTER WAX FACT: Koster Keunen was founded in the Netherlands and is world renowned for supplying quality waxes. 1852 OUR HISTORY OF TRADITION AND INNOVATION Founded in 1852 as a family business, Koster Keunen has evolved into the world’s leading processor, refiner and marketer of natural waxes. From the early days of sun bleaching beeswax for the candle industry, we now specialize in processing and formulating quality waxes for cosmetics, pharmaceutical, food, coatings, and various other technical industries worldwide. For over 150 years we have sought perfection, constantly introducing new and innovative processes and waxes, while investing in experienced, knowledgeable people and the best equipment to help meet this goal. As a family business we believe very strongly in the need for developing 3 superior quality products, and supporting our customers with excellent service, throughout the formulation and marketing processes. From our two facilities, in the USA and Holland, we offer a huge range of natural waxes, synthetic waxes and wax derivatives, enabling our customers to produce thousands of products that look, feel and work superbly KOSTERKEUNEN.COM / 1 860.945.3333 KOSTER WAX FACT: Koster Keunen was the first natural wax company to manufacture waxes using a Sandvik Pastillator, starting in 1988. 1852 UNIQUELY KOSTER KEUNEN Our greatest strength is the experience and scientific expertise we have fostered for the development of new and innovative products.
    [Show full text]
  • API & Dosage Form Development
    API and Dosage Development W I T H D A LT O N Peter Pekos [ C O M P A N Y V I S I O N ] "To make the impossible possible. Dalton Pharma Services uses its scientific and pharmaceutical expertise to bring customer ideas to life. We develop their new drug products, optimize the synthesis of therapeutic candidates, and manufacture them at the highest level of quality." [ S E R V I C E S ] Contract Research Custom Synthesis Medicinal and Flow Chemistry API Process Development Formulation Development cGMP API Manufacturing cGMP Sterile Filling Analytical and Microbiology Services FDA inspected, HC approved, & MRA with EMA API Form Development API Definition Active pharmaceutical ingredient (API) – the substance(s) in pharmaceutical drugs that is/are responsible for the beneficial health effects experienced by consumers. (1) API Selection Key factors that drive API selection (2): Crystallinity: Influences the dissolution rate and transport characteristics of the drug (3) Polymorphism: The ability of a drug substance to Solubility: take on more than one form/ The ability of a solute to dissolve in crystalline phase. Influences drug solvent. Influences desired dissolution and drug stability (i.e., concentration and drug premature degradation) (4) absorption (6) Density: Influences flow properties and Stability: compressibility (5) Influenced by moisture, excipients, temperature, pH, oxygen, light (7) Particle size distribution: Influences the ability of the drug to Density: cross blood barriers, enter cells, Influences flow properties and and absorbed by the human body compressibility (5) (2) The development stage and needs API & CTD Note: In any clinical application or new drug submission the 1) description of manufacturing (including flowcharts) is required along with 2) physiochemical characteristics (melting point, boiling point, denaturation temperature, solubility) (2.3.S.2, 2.3.S.3 and 2.3.P.3) (4) Once the API form is determined, the dosage form must be selected.
    [Show full text]
  • Novel Dry Powder Inhaler Formulation Containing Antibiotic Using Combined Technology to Improve Aerodynamic Properties
    Novel dry powder inhaler formulation containing antibiotic using combined technology to improve aerodynamic properties Rita Ambrus 1* , Edit Benke 1, Árpád Farkas 2, Imre Balásházy 2, Piroska Szabó-Révész 1 1Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary 2Centre for Energy Research, Hungarian Academy of Sciences, Budapest, Hungary *Corresponding author: [email protected] Abstract Dry Powder Inhaler (DPI) could offer a propellant-free, easy-to-use powder form ensuring better stability than liquid dosage forms. Therefore the development of traditional carrier-based and carrier-free new generation systems is a determinative factor in the field of DPI formulation. The purpose of our research work was to combine these two systems, utilizing their beneficial properties to produce a novel pulmonary drug delivery system containing ciprofloxacin hydrochloride (CIP). Co-spray drying, surface smoothing and the preparation of an interactive physical mixture were applied as the technological procedures of sample preparation. The carrier-based and carrier-free formulations, as well as the developed novel product were compared to each other. Structural investigations were made by X-ray powder diffraction and micrometric properties (habit, bulk density) were determined. Particle interactions were also evaluated to investigate surface free energy, cohesive-adhesive forces, and spreading coefficient. In vitro aerodynamic properties (mass median aerodynamic diameter, fine particle fraction (FPF) and emitted dose of DPIs were measured using Andersen Cascade Impactor. A novel in silico Stochastic Lung Model was also used to quantify the amount of particles deposited at the target area. The novel-formulated composition presented amorphous spherical particles with an average size of about 2 µm.
    [Show full text]
  • Randomised, Double-Blind, Placebo-Controlled Study of A
    J Pharm Pharmaceut Sci (www.cspsCanada.org) 15(2) 281 - 294, 2012 Randomised, Double-Blind, Placebo-Controlled Study of a Single Dose of an Amylmetacresol/2,4-dichlorobenzyl Alcohol Plus Lidocaine Lozenge or a Hexylresorcinol Lozenge for the Treatment of Acute Sore Throat Due to Upper Respiratory Tract Infection Damien McNally,1 Adrian Shephard,2 Emma Field3 1 Ormeau Health Centre, Belfast, UK; 2 Professional Relations, Reckitt Benckiser, Slough, UK; 3 Global Medical Affairs, Reckitt Benckiser Healthcare, Hull, UK. Received, January 31, 2012; Revised, February 24, 2012; Accepted, April 1, 2012; Published, April 2, 2012. ABSTRACT - Purpose: Sore throat is a frequent reason for seeking medical care but few prescription options are available. Lozenges are effective in delivering active ingredients to the throat. This study was conducted to determine the analgesic efficacy of two lozenges one containing amylmetacresol (AMC)/2,4- dichlorobenzyl alcohol (DCBA) and lidocaine and one containing hexylresorcinol versus placebo in patients with acute sore throat due to upper respiratory tract infection (URTI). Methods: This was a multicentre, randomised, double-blind, parallel group, placebo-controlled study. In total, 190 patients were randomised 1:1:1 to a single dose of AMC/DCBA + lidocaine, hexylresorcinol or placebo lozenge. Subjective ratings of throat soreness, difficulty swallowing, swollen throat, numbing, and sore throat relief were obtained up to 2 hours post dose. Patient and investigator global ratings and a consumer questionnaire
    [Show full text]
  • Manufacture and Characteristics of Pastilles and Their Coating by Crystallization Process
    MANUFACTURE AND CHARACTERISTICS OF PASTILLES AND THEIR COATING BY CRYSTALLIZATION PROCESS DISSERTATION zur Erlangung des akademischen Grades Doktor-Ingenieur (Dr.-Ing.) genehmigt durch die Mathematisch-Naturwissenschaftlich-Technische Fakultät (Ingenieurwissenschaftlicher Bereich) der Martin-Luther-Universität Halle-Wittenberg von Herrn M.Sc. Jung-Woo Kim geb. am 20.08.1972 in KyoungNam / Süd Korea Dekan der Fakultät: Prof. Dr. Ludwig Staiger Gutachter: 1. Prof. Dr. -Ing. habil. Joachim Ulrich 2. Prof. Dr. habil. Karsten Mäder 3. Dr. -Ing. Ulrich Teipel Halle (Saale), den 15. 12. 2003 urn:nbn:de:gbv:3-000006229 [http://nbn-resolving.de/urn/resolver.pl?urn=nbn%3Ade%3Agbv%3A3-000006229] CONTENTS CONTENTS 1. INTRODUCTION ……………………………………………......…………... 1 2. TECHNICAL BACKGROUND AND THEORY ………………………….. 3 2.1. Melt solidification ……………………………………………………..... 3 2.1.1. Technical background of melt solidification processes ………..…. 3 2.1.2. Approximation of crystallization rate ………………………..…… 5 2.1.3. Degree of deformation ………………………………………..…... 5 2.2. Porosity ……………………………………………………………..…... 7 2.3. Nucleation and crystal growth in solution …………………………..….. 11 2.3.1. Nucleation ……………………………………………………..….. 11 2.3.1.1. Types of nucleation …………………………………..……... 11 2.3.1.2. Kinetic of nucleation …………………………………..……. 12 2.3.1.3. Surface nucleation ……………………………………..……. 14 2.3.2. Growth rate …………………………………………………..…… 16 2.3.2.1. Theory of crystal growth ………………………………..…... 16 2.3.2.2. Kinetic of crystal growth ………………………………..…... 17 2.4. Agglomeration mechanism ………………………………………...…….. 19 2.5. Interfacial tension …………………………………………………..……. 21 2.6. Seeding technology ………………………………………………..…….. 23 3. STATE OF ART AND OBJECTIVES OF THESIS ………………....…….. 24 3.1. State of art …………………………………………………………..…... 24 3.1.1. Crystallization time of drops ………………………………..…….. 24 3.1.2. Coating mechanism in a crystallization process ……………..…… 25 3.1.2.1.
    [Show full text]