1166 th AAnnnnuuaall SSyymmppoossiiuumm

OOnn TThhee CCaannnnaabbiinnooiiddss

2006 Program . Registration June 24, 2006 (1600-2000)

Day 1 Sunday, June 25th

7.50 - 8.00 OPENING REMARKS Session 1. SAR Studies and New Synthetic Molecules ¾ Chairs: Drs. Brian Thomas and Raj Razdan Page # THE RELEVANCE OF THE STERIC FACTOR Yehoshua Maor, Ruth Gallily IN THE BIOLOGICAL ACTIVITY OF CBD 8.00 DERIVATIVES – 1 and Raphael Mechoulam A TOOL IN IDENTIFYING NOVEL MOLECULAR TARGET FOR CANNABINOIDS 1-PENTYL-2-ARYL-4-(1- John W. Huffman, Lea W. Padgett, NAPHTHOYL)PYRROLES: A NEW 2 Matthew L. Isherwood, Jenny L. Wiley 8.15 CLASS OF HIGH AFFINITY LIGANDS and Billy R. Martin FOR THE CB1 AND CB2 RECEPTORS T.M. Fong, L.S. Lin, X-M Guan, D.J. Marsh, C-P Shen, J. Lao, D.S. Stribling, K.M. Rosko, H. Yu, Y. Feng, J.C. Xiao , L.H.T. Van der Ploeg, M.T. Goulet, W.K. DISCOVERY OF A NOVEL CB1R 3 8.30 Hagmann, T.J. Lanza, Jr., J.P. Jewell, P. Liu, S.K. Shah, H. Qi, X. Tong, J. Wang, and S. Xu, R. Gibson, B. INVERSE AGONIST Francis, S. Patel, A.M. Strack, D.E. MacIntyre and L.P. Shearman Yanan Zhang, Marcus Brackeen, Anne CONFORMATIONALLY-CONSTRAINED 4 Gilliam, Herbert Seltzman 8.45 ANALOGS OF SR141716 and Brian Thomas Session 2. Receptor Structure and Signal Transduction ¾ Chairs: Drs. Ruth Ross and Allyn Howlett Itai Bab, Joseph Tam, Orr Ofek, Catherine Ledent, Ester Fride, Yankel Gabet, Ralph INVOLVEMENT OF CB1 SIGNALLING 9.00 Müller, Andreas Zimmer, Ken Mackie, IN BONE REMODELLING 5 Raphael Mechoulam and Esther Shohami Sharon Anavi-Goffer, Daniel Fleischer, Dow P. Hurst, Diane L. Lynch, Judy Barnett-Norris, HELIX 8 LEUCINE OF CB1 9.15 Shanping Shi, Deborah L. Lewis, Somnath CANNABINOID RECEPTOR PROMOTES 6 Mukhopadhyay, Allyn C. Howlett, SELECTIVE G PROTEIN COUPLING Patricia H. Reggio and Mary E. Abood Sergio Oddi, Monica Bari, Filomena Fezza, LIPID RAFTS, CB2 RECEPTOR Valeria Gasperi, Paola Spagnuolo, Nicoletta SIGNALING AND METABOLISM OF 9.30 Pasquariello, Alessandro Finazzi-Agrò 2-ARACHIDONOYL-GLYCEROL IN 7 and Mauro Maccarrone HUMAN IMMUNE CELLS

i IS AN INVERSE AGONIST Adèle Thomas, Gemma Baillie, Alexander AND EXHIBITS UNEXPECTEDLY HIGH 9.45 Phillips, Ruth Ross and Roger Pertwee POTENCY AS AN ANTAGONIST AT MOUSE 8 BRAIN CB1 AND HUMAN CB2 RECEPTORS

Ruth A. Ross, Gemma L. Baillie, Cherry Alexander, Emma Baillie, Lisa Gauson, Sarah ALLOSTERIC MODULATION OF THE 10.00 Robertson, Lesley A. Stevenson, Kirsty CANNABINOID CB1 RECEPTOR: NOVEL 9 Muirhead, Laurent Trembleau ALLOSTERIC MODULATORS and Roger G. Pertwee

CB1 CANNABINOID RECEPTORS Allyn Howlett, Jenelle Jones MEDIATE TRANSLOCATION OF NO- 10.15 and Derek Norford SENSITIVE GUANYLYL CYCLASE IN 10 NEURONAL CELLS

10.30 - 11.00 Coffee Break

RAPID RECEPTOR DESENSITIZATION Christopher Kearn, Giovanna Cacciola, MODULATES CANNABINOID 11.00 Tanya Daigle and Ken Mackie RECEPTOR ACTIVATION OF P42/P44 11 MAP KINASE THE EFFECTS OF CHRONIC 11.15 Chris Breivogel and Vanita Puri CANNABINOIDS IN 12 BETA-ARRESTIN2 -/- MICE CELLULAR SIGNALING PROPERTIES OF Neta Rimmerman, Heather Bradshaw, THE NEWLY IDENTIFIED FATTY ACID 11.30 AMIDE N-PALMITOYL GLYCINE 13 David O’Dell and J. Michael Walker FOUND IN RAT CENTRAL NERVOUS SYSTEM AND SKIN Patricia Reggio, Dow Hurst, Diane Lynch, CB1 L7.60I AND L7.60F MUTATIONS RESULT IN CONFORMATIONAL CHANGES IN HELIX Judy Norris, Sharon Anavi-Goffer 11.45 8 R7.56(400)-K7.58(402) ELBOW AND 14 and Mary Abood INTRACELLULAR FACE REGIONS OF CB1

12.00 - 12.15 Free Time

12.15 - 13.45 Lunch

Session 3. Bioactive Lipids & Analytical Lipidology ¾ Chairs: Drs. Rao Rapaka and Heather Bradshaw MECHANISMS IN THE BIOSYNTHESIS George Kunos 13.45 OF CRITICAL LIPIDS UPDATE ON NEW ENDOGENOUS Raphael Mechoulam 14.00 LIPID LIGANDS LIPIDOMIC APPROACHES TO THE 14.15 J. Michael Walker IDENTIFICATION OF NOVEL, 15 ENDOGENOUS FATTY ACYL AMIDES Mauro Maccarrone, Anna Fiori, Monica Bari, Filippo Granata, Valeria Gasperi, M. TRANSPORT ACROSS 14.30 Egle De Stefano, Alessandro Finazzi-Agrò THE BLOOD-BRAIN BARRIER 16 and Strom ANALYTICAL PROTEOMICS & FISHING Alexandros Makriyannis 14.45 FOR THE PHARMACOPHORE "VANILLIPIDOMICS": AN UPDATE ON Vincenzo Di Marzo ENDOGENOUS LIPID LIGANDS OF 15.00 and Luciano De Petrocellis 17 VANILLOID RECEPTORS 15.15 Daniele Piomelli LIPIDOMICS: THEN AND NOW

ii

Coffee Break / Poster Session 15.30 - 17.30 Sessions # 2 and 4

Session 4. Biosynthesis and Inactivation of Endocannabinoids and Related Lipids ¾ Chairs: Drs. Sherrye Glaser and Nephi Stella Jenny Wang, David Woodward, Alex LACK OF EFFECT OF FATTY ACID AMIDE HYDROLASE (FAAH) INHIBITORS ON Kharlamb, Benjamin Cravatt, Giorgio Ortar 17.30 INTRAOCULAR PRESSURE IN 18 and Vincenzo Di Marzo “GLAUCOMATOUS” MONKEYS DOES THE INITIAL CELLULAR UPTAKE OF ANANDAMIDE SHOW Christopher Fowler and Lina Thors 17.45 TEMPERATURE-DEPENDENCY AND 19 SATURABILITY? IDENTIFICATION OF A NOVEL Nephi Stella 18.00 MONOACYLGLYCEROL LIPASE (MGL) 20 FAAH (-/-) MICE EXHIBIT NORMAL CB1 Andrew J. Thorpe, Joel, Schlosburg, RECEPTOR FUNCTION FOLLOWING Benjamin F. Cravatt, Billy R. Martin, Laura 18.15 ACUTE OR REPEATED 21 J. Sim-Selley and Aron H. Lichtman ADMINISTRATION OF CANNABINOIDS Heather Bradshaw, Sherry Shu-Jung Hu, NOVEL METABOLISM OF N- Neta Rimmerman, David O'Dell, Kim ARACHIDONOYL GLYCINE BY FATTY 18.30 Masuda, Benjamin Cravatt 22 ACID AMIDE HYDROLASE and J Michael Walker Bo Tan, Heather B. Bradshaw, David K. RAPID IDENTIFICATION OF NOVEL O'Dell, M. Francesca Monn, Y. William ENDOGENOUS FATTY ACYL AMIDES USING 18.45 Yu, Harini Srinivasan, Jocelyn F. Krey NANO-LC-MS/MS AND INFORMATION- 23 and J. Michael Walker DEPENDENT ACQUISITION

20.00 Dinner

Notes:

iii Day 2 Monday, June 26th

Session 5. Neuronal Development ¾ Chairs: Drs. Tibor Harkany and Tiziana Rubino Paul Berghuis, Michela Matteoli, Ken NEURONAL GROWTH CONE GUIDANCE 8.00 Mackie and Tibor Harkany BY ENDOCANNABINOIDS 24 THE ACTIVATION OF CANNABINOID María Gómez, Mariluz Hernández, Ruth RECEPTORS DURING BRAIN Pazos, Rosa Tolón, Julián Romero 8.15 DEVELOPMENT INFLUENCES CELL 25 and Javier Fernández-Ruiz ADHESION MOLECULE L1 IN RATS Session 6. Nervous Function and Neuropsychiatric Disorders ¾ Chairs: Drs. Tibor Harkany and Tiziana Rubino FURTHER EVIDENCE FOR THE INVOLVEMENT OF CB2 CANNABINOID Emmanuel Onaivi and Hiroki Ishiguro 8.30 RECEPTORS IN DEPRESSION AND 26 SUBSTANCE ABUSE József Haller, Krisztina Soproni, Balázs CORRELATED SPECIES DIFFERENCES IN THE Varga, Beáta Németh, Éva Mikics, EFFECTS OF CANNABINOID LIGANDS ON 8.45 ANXIETY AND ON GABAERGIC / 27 Tamás F. Freund, Ferenc Mátyás GLUTAMATERGIC SYNAPTIC and Norbert Hájos TRANSMISSION NEUROANATOMICAL SITES AND Tiziana Rubino, Cinzia Guidali, Natalia BIOCHEMICAL CORRELATES Realini, Daniela Viganò, Chiara Castiglioni 9.00 UNDERLYING CANNABINOID 28 and Daniela Parolaro MODULATION OF ANXIETY CB1 RECEPTOR ANTAGONISTS IN THE 9.15 Aldemar Degroot and George Nomikos PHARMACOTHERAPY OF ACTIVE 29 AVOIDANCE RELATED ANXIETY INVOLVEMENT OF THE 5-HT1A Paola Fadda, Maria Scherma, Paola Salis, SEROTONERGIC RECEPTORS IN THE 9.30 Paola Mascia, Liana Fattore ANXIETY-LIKE EFFECTS INDUCED BY THE 30 and Walter Fratta CB1 CANNABINOID RECEPTOR AGONIST WIN55,212-2 CANNABIDIOL REVERSES MK-801- Leonora Long, Daniel Malone INDUCED SOCIAL WITHDRAWAL 9.45 and David Taylor 31 IN RATS A EXTRACT ALTERS 10.00 Richard Musty and Richard Deyo BEHAVIORAL DISPAIR IN AN ANIMAL 32 MODEL OF DEPRESSION Aron Lichtman, Pattipati Naidu, Stephen FAAH INHIBITION AUGMENTS ANANDAMIDE’S PHARMACOLOGICAL Varvel, Kyunghye Ahn, Benjamin Cravatt 10.15 EFFECTS BUT IS DEVOID OF ANXIOLYTIC- 33 and Billy Martin LIKE OR ANTIDEPRESSANT-LIKE EFFECTS

10.30 - 11.00 Coffee Break

Session 7. Nervous Function: Retrograde Signalling, Memory and Learning ¾ Chairs: Drs. Gregory Gerdeman and Krisztina Monory Norbert Hajos, Judit Makara, Istvan INVOLVEMENT OF NITRIC OXIDE IN 11.00 Katona, Jan de Vente CB1 CANNABINOID RECEPTOR- 34 and Tamas Freund MEDIATED RETROGRADE SIGNALING

iv D2 RECEPTORS MEDIATE FREQUENCY- DEPENDENT PRESYNAPTIC INHIBITION VIA 11.15 Henry Yin and David Lovinger RETROGRADE ENDOCANNABINOID 35 SIGNALING AT CORTICOSTRIATAL SYNAPSES ENDOCANNABINOID MODULATION OF GABA RELEASE AT THE CCK+ INTERNEURON TO PYRAMIDAL CELL Csaba Foldy, Axel Neu and Ivan Soltesz 11.30 SYNAPSE, A KEY SITE FOR THE 36 REGULATION OF HIPPOCAMPAL NETWORK OUTPUT Istvan Katona, Gabriella Urban, Matthew THE ENDOCANNABINOID SYSTEM AT Wallace, Catherine Ledent, Kwang-Mook GLUTAMATERGIC SYNAPSES OF THE 11.45 Jung, Daniele Piomelli, Ken Mackie 37 BRAIN and Tamas F Freund INHIBITION OF STIMULUS-RESPONSE Gregory Gerdeman, Jason Schechter (HABIT) LEARNING BY STRIATAL 12.00 and Edward French INJECTION OF THE CB1 38 ANTAGONIST

12.15 - 13.45 Lunch

Session 8. Pain and Inflammation ¾ Chairs: Drs. Barbara Costa and Michael Walker PATHOPHYSIOLOGICAL ROLES OF 2- Takayuki Sugiura, Maiko Gokoh, Seishi ARACHIDONOYLGLYCEROL AND THE 13.45 Kishimoto and Saori Oka CB2 RECEPTOR IN ALLERGIC 39 INFLAMMATION EFFECT OF CB1/TRPV1 AGONIST, Barbara Costa, Francesca Comelli, Mariapia ARVANIL, IN ACUTE INFLAMMATION 14.00 Colleoni and Gabriella Giagnoni AND IN PERSISTEN INFLAMMATORY 40 AND NEUROPATHIC PAIN INHIBITION OF FAAH PRODUCES CB1 RECEPTOR MEDIATED ANTI- Sreenivasulu Pattipati and Aron Lichtman 14.15 HYPERALGESIC EFFECTS IN 41 COLLAGEN-INDUCED ARTHRITIC PAIN Rossella Brusa, Marilena Campanella, Giorgia Quadrato, Nadia Bernardini, Chiara Foglia, CB2 RECEPTOR AGONISTS 14.30 Valentina Liporati, Silvia Conti, 42 Rosalia Bertorelli, Angelo Reggiani PHARMACOLOGICAL PROFILING and Massimiliano Beltramo ACUTE INTERACTIONS BETWEEN CBD, Stephen Varvel, Jenny Wiley CBN, AND THC FOLLOWING 14.45 and Billy Martin INTRAVENOUS OR INHALATION 43 EXPOSURE IN THE MOUSE TETRAD

Coffee Break / Poster Session 15.00 - 17.15 Sessions # 1, 6, 7 and 8

Session 9. Food Intake and Energy Balance ¾ Chairs: Drs. Ester Fride and Jenny Wiley UNDESIRABLE WEIGHT GAIN CAUSED BY PROLONGED USE OF ANTI-DEPRESSANT 17.15 Ester Fride and Nikolai Gobshtis MEDICATION MAY BE PREVENTED WITH 44 RIMONABANT WITHOUT LOSS OF ANTIDEPRESSANT EFFECTIVENESS

v Frédéric Béquet, Mathieu Desbazeille, CB1 RECEPTORS CONTROL Pascal Ludwiczak, Mohamed Maftouh, ENDOCANNABINOIDS RELEASE IN THE 17.30 Claudine Picard, Bernard Scatton HYPOTHALAMUS OF FREELY MOVING 45 and Gérard Le Fur RATS FUNCTIONAL ACTIVITY OF Isabel Matias, Luciano De Petrocellis, CANNABINOID RECEPTORS IN MODELS Katarzyna Starowicz, Tiziana Bisogno, 17.45 OF ADIPOCYTES AND 46 Luigia Cristino and Vincenzo Di Marzo BETA-PANCREATIC CELLS M. Jerry Wright Jr., James J. Burston, THE INFLUENCE OF SELECTED 18.00 Darnica C. Leggett, Raj K. Razdan ENDOCANNABINOID ANALOGS ON 47 and Jenny L. Wiley FOOD INTAKE AND LOCOMOTION

Plenary Lecture Kang Tsou Memorial Lecture Dr. Miklós Palkovits 18.15 - 19.00 Semmelweis University “Neuroanatomical and Neurochemical Organization of the Central Regulation of Food Intake” Page P1

20.00 Boat Excursion with Dinner

Notes:

vi

Day 3 Tuesday, June 27th

Session 10: Immune System ¾ Chairs: Drs. David Baker and Mauro Maccarrone Fernando Correa, Fabian Docagne, Leyre ANANDAMIDE REGULATES IL-12P40 Mestre, Diego Clemente, Frida Loría, PRODUCTION BY ACTIVATING THE 8.00 Miriam Hernangómez, Christoph Becker PROMOTER REPRESSOR 48 and Carmen Guaza ELEMENT GA-12 ENDOCANNABINOID METABOLITES 8.15 Douglas McHugh and Ruth A. Ross MODULATE HUMAN NEUTROPHIL 49 MIGRATION David Baker, J. Croxford Croxford, Gareth Pryce, CANNABINOID-MEDIATED Samuel M. Jackson, Catherine Ledent, Giovanni IMMUNOSUPPRESSION IN 8.30 Marsicano, Beat Lutz, Gavin Giovannoni, EXPERIMENTAL ALLERGIC 50 Takashi Yamamura and Roger G Pertwee ENCEPHALOMYELITIS CANNABINOID RECEPTOR-MEDIATED MODULATION OF LIPOPOLYSACCHARIDE- Michelle Roche, Michael Diamond, INDUCED ALTERATIONS IN PERIPHERAL 8.45 John P. Kelly and David P. Finn CYTOKINE LEVELS, CIRCULATING 51 LYMPHOCYTES AND HYPOTHALAMO- PITUITARY-ADRENAL AXIS ACTIVITY IN RATS ROLE OF THE ENDOGENOUS Evelyn Gaffal, Meliha Karsak, Regina CANNABINOID SYSTEM IN Steuder, Andreas Zimmer 9.00 EXPERIMENTAL CONTACT 52 and Thomas Tüting HYPERSENSITIVITY A PRELIMINARY IMMUNOLOGICAL Norbert Kaminski, Alison Springs and CHARACTERIZATION OF CB1-/-/CB2-/- 9.15 MICE AND THEIR SENSITIVITY TO 53 Barbara Kaplan IMMUNE MODULATION BY ∆9- Session 11: Cardiovascular, Gastrointestinal and Other Peripheral Functions ¾ Chairs: Drs. Somnath Mukhopadhyay and David Kendall Emma Robinson, Sue Pyne, Nigel Pyne, EFFECT OF CANNABINOIDS ON RAT 9.30 Ros Brett, Kathy Kane and Simon Kennedy CORONARY ARTERY REACTIVITY 54 SYNTHETIC AND PLANT-DERIVED Nissar Darmani, Jennifer Crim CANNABINOIDS PREVENT 9.45 and Jano Janoyan RADIATION-INDUCED VOMITING 55 VIA CB1-RECEPTOR THE RECEPTORS MEDIATING THE INHIBITORY EFFECTS OF CANNABINOIDS ON THE Raj Makwana, Areles Molleman ELECTRICALLY STIMULATED RAT ISOLATED 10.00 and Mike Parsons MYENTERIC PLEXUS LONGITUDINAL MUSCLE 56 PREPARATION ARE DEPENDENT ON THE FREQUENCY OF STIMULATION ENDOCANNABINOIDS AFFECT LIVER Yosefa Avraham, Olga Zolotarev, Yossi FUNCTION IN THIOACETAMIDE Dagon, Iddo Magen, Raphael Mechoulam, 10.15 INDUCED HEPATIC 57 Yaron Ilan and Elliot Berry ENCEPHALOPATHY

10.30 - 11.00 Coffee Break

LPS TREATMENT UPREGULATES CB2 Marnie Duncan, Quentin Pittman, Ken RECEPTORS IN THE ENTERIC NERVOUS 11.00 Mackie, Kamala Patel and Keith Sharkey 58 SYSTEM OF THE RAT ILEUM

vii CANNABINOID LIGANDS AS Saoirse O'Sullivan, Andrew Bennett, ACTIVATORS OF PEROXISOME 11.15 David Kendall and Michael Randal PROLIFERATOR-ACTIVATED 59 RECEPTOR GAMMA (PPAR GAMMA) Fatima Teixeira-Clerc, Boris Julien, Pascale Grenard, CB1 CANNABINOID RECEPTOR Jeanne Tran Van Nhieu, Vanessa Deveaux, Lyling Li, ANTAGONISM: A NOVEL STRATEGY 11.30 Valérie Serriere-Lanneau, Catherine Ledent, FOR THE TREATMENT OF LIVER 60 Ariane Mallat and Sophie Lotersztajn FIBROSIS ANANDAMIDE-MEDIATED ANGIOGENESIS: INTERPLAY BETWEEN Somnath Mukhopadhyay 11.45 CB1 RECEPTOR AND NON-CB1/CB2 61 ANANDAMIDE RECEPTOR Lunch 12.00 -14.00 NIDA InfoLuncheon – European/American Funding Initiatives Session 12: Human and Clinical Studies ¾ Chairs: Drs. Ethan Russo and Roger Pertwee SATIVEX® CANNABIS BASED MEDICINE IMPROVES SLEEP QUALITY IN PATIENTS 14.00 Ethan Russo WITH MULTIPLE SCLEROSIS, NEUROPATHIC 62 AND RHEUMATIC PAIN REPORT ON A CASE SERIES OF PATIENTS Mary Lynch, Christine Short, USING A BUCCAL CANNABIS EXTRACT 14.15 CONTAINING THC AND CBD FOR 63 Young Judee and Joanne Walker TREATMENT OF NEUROPATHIC PAIN AND SPASTICITY FOLLOW UP STUDY OF PATIENTS WITH Marta Duran, Sergio Abanades, Dolors NEUROPATHIC PAIN, SPASTICITY SECONDARY TO 14.30 MULTIPLE SCLEROSIS AND ANOREXIA CAQUEXIA 64 Capellà and Seguivex Study Group SYNDROME TREATED WITH A WHOLE PLANT CANNABIS EXTRACT Donald Abrams, Hector Vizoso, Starley VAPORIZATION AS A SAFE AND 14.45 Shade, Cheryl Jay, Mary Ellen Kelly EFFICIENT SMOKELESS CANNABIS 65 and Neal Benowitz DELIVERY SYSTEM David Gorelick, Silvia Martins, Marc Copersino, RISK OF CANNABIS DEPENDENCE Carl Soderstrom, Gordon Smith, Patricia 15.00 Dischinger, David McDuff, J. Richard Hebel, IN CANNABIS USERS AMONG 66 Timothy Kerns, Shiu Ho and Kathleen Read TRAUMA INPATIENTS Matthew Hill, Greg Miller, Erica DYNAMIC REGULATION OF SERUM ENDOCANNABINOID CONTENT IN 15.15 Carrier, Vanessa Ho, Boris Gorzalka AFFECTIVE DISEASE AND FOLLOWING 67 and Cecilia Hillard SOCIAL STRESS IN HUMANS Coffee Break / Poster Session 15.30 - 18.15 Sessions # 9 - 12

Hot and Controversial Issue Session #1:

17.45 - 18.15 “Are There CB2 Receptors in CNS Neurons?” Chairs: Drs. Emmanuel Onaivi and Marnie Duncan

Plenary Lecture Dr. Angelo Izzo 18.15 - 19.00 “Cannabinoids and the Gut: Focus on Intestinal Motility and Secretion” Young Investigator Award Page P2

20.00 Dinner

viii Day 4 Wednesday, June 28th

Session 13: Reward and Abuse ¾ Chairs: Drs. Daniela Parolaro and Thomas Lundqvist PREVIOUS EXPOSURE TO THC Leigh Panlilio, Marcello Solinas, ALTERS THE REINFORCING Stephanie Matthews 8.00 EFFECTS AND ANXIETY-RELATED 68 and Steven Goldberg EFFECTS OF COCAINE IN RATS ENDOCANNABINOIDS MEDIATE ETHANOL- Balapal Basavarajappa, Ninan Ipe, INDUCED MODULATION OF EXCITATORY 8.15 Thomas Cooper and Ottavio Arancio POSTSYNAPTIC CURRENTS IN CULTURED 69 HIPPOCAMPAL NEURONS Mariaelvina Sala, Chiara Castiglioni, INVOLVEMENT OF THE CB1 Valeria Limonta, Chiara Guerini- CANNABINOID RECEPTOR ON 8.30 Rocco, Alessia Zani, Simona Pegorini 70 SALVINORIN-A-INDUCED REWARD and Daniela Braida MAPPING CANNABIDIOL-INDUCED Ros Brett, Claire Allison ALTERATIONS IN REGIONAL BRAIN 8.45 and Judith Pratt ACTIVITY BY 2-DEOXYGLUCOSE 71 IMAGING Raffaella Tonini, Sonia Ciardo, Milica ERK-DEPENDENT MODULATION OF Cerovic, Tiziana Rubino, Daniela CEREBELLAR SYNAPTIC PLASTICITY 9.00 Parolaro, Michele Mazzanti FOLLOWING CHRONIC ∆9- 72 and Renata Zippel TETRAHYDROCANNABINOL EXPOSURE Marco Pistis, Simona Perra, Giuliano THE ENDOCANNABINOID SYSTEM IN THE EFFECTS OF ALCOHOL ON LIMBIC Pillolla, Anna Lisa Muntoni 9.15 NEURONS: ELECTROPHYSIOLOGICAL 73 and Miriam Melis EVIDENCE IN VIVO CB1 RECEPTOR ANTAGONIST AM251 Eliot Gardner, Zheng-Xiong Xi, Jeremy INHIBITS COCAINE'S REWARDING EFFECTS 9.30 Gilbert, Arlene Pak, Xiao-Qing Peng AND COCAINE-PRIMED RELAPSE TO DRUG- 74 and Xia Li SEEKING BEHAVIOR IN RATS BY A DA- INDEPENDENT MECHANISM Sara Jane Ward, Henry, CANNABINOID CB1 RECEPTOR DELETION Ashmita Chatterjee, Tonya Gerald, AND CB1 RECEPTOR ANTAGONISM BOTH 9.45 Steven Franklin, Allyn Howlett ENHANCE MORPHINE CONDITIONED PLACE 75 and Linda Dykstra PREFERENCE Session 14: Cancer ¾ Chairs: Drs. Raphael Mechoulam and Vincenzo Di Marzo THE NOVEL ANTICANCER CANNABINOID Natalya Kogan, Michael Schlesinger, QUINONE HU-331 IS MORE POTENT AND 10.00 Ronen Beeri and Raphael Mechoulam LESS CARDIOTOXIC THAN DOXORUBICIN - 76 A COMPARATIVE IN-VIVO STUDY ANTI-CANCER EFFECTS OF CANNABIDIOL Alessia Ligresti, Aniello Schiano Moriello, Isabel IN HUMAN BREAST CARCINOMA: Matias, Katarzyna Starowicz, Simona Pisanti, CELLULAR AND MOLECULAR MECHANISMS 10.15 Luciano De Petrocellis, Giuseppe Portella, 77 OF ACTION AND INHIBITION OF Maurizio Bifulco and Vincenzo Di Marzo METASTATIC SPREADING

10.30 - 11.00 Coffee Break

ix Simona Pisanti, Cristina Borselli, ANANDAMIDE INHIBITS Olimpia Oliviero, Patrizia Gazzerro, ENDOTHELIAL CELL SPROUTING 11.00 Chiara Laezza, Claudia Grimaldi ANGIOGENESIS IN VITRO 78 and Maurizio Bifulco AND IN VIVO INHIBITION OF COX-2 PROTECTS Burkhard Hinz, Robert Ramer HUMAN CERVICAL CARCINOMA CELLS 11.15 and Karin Eichele FROM R(+)-- 79 INDUCED APOPTOTIC DEATH Session 15: Neuroprotection ¾ Chairs: Drs. Javier Fernandez-Ruiz and Julián Romero Fabian Docagne, Vilma Muñeton, Frida NEUROPROTECTIVE EFFECTS OF Loría, Diego Clemente, Fernando CANNABINOIDS INDUCE THERAPEUTIC 11.30 Correa, Miriam Hernangómez, PROPERTIES IN A VIRAL MODEL OF 80 Leyre Mestre and Carmen Guaza MULTIPLE SCLEROSIS Joseph Tam, Alex Alexandrovich, Vincenzo CB1, BUT NOT CB2, MEDIATES Di Marzo, Stefania Petrosino, Victoria STIMULATION OF BONE 11.45 Trembovler, Andreas Zimmer, Raphael FORMATION INDUCED BY 81 Mechoulam, Esther Shohami and Itai Bab TRAUMATIC BRAIN INJURY SR141716A IMPROVES COGNITIVE Iddo Magen, Yosefa Avraham, Zvi AND NEUROLOGICAL FUNCTION IN Ackerman, Raphael Mechoulam 12.00 A MODEL OF SECONDARY BILIARY 82 and Elliot M. Berry CIRRHOSIS IN THE RAT

12.15 - 13.45 Lunch

Cristina Benito, Juan Pablo Romero, IMMUNOHISTOCHEMICAL STUDY OF Diego Clemente, Fabian Docagne, THE ENDOGENOUS CANNABINOID 13.45 Rosa María Tolón, Carmen Guaza SYSTEM IN MULTIPLE SCLEROSIS 83 and Julián Romero POSTMORTEM HUMAN SAMPLES David Fernández-López, Ignacio WIN 55,212-2 IMPROVES CEREBRAL TISSUE Lizasoain, Maria Angeles Moro, RECOVERY AFTER EXPERIMENTAL 14.00 Pedro Lorenzo and NEWBORN HYPOXIA-ISCHEMIA IN A CB1 84 Jose Antonio Martínez-Orgado AND CB2 RECEPTOR DEPENDENT MANNER A SINGLE ULTRA-LOW DOSE OF THC Yosef Sarne, Isabella Tselnicker, INDUCES LONG-LASTING 14.15 COGNITIVE DEFICITS IN MICE: 85 Roey Senn and Ora Keren IMPLICATIONS FOR CHRONIC EXPOSURE TO CANNABINOID DRUGS Cindy Casteels, Dorien Vercammen, CHRONIC EXPOSURE TO Karolien Goffin, Peter Vermaelen, ∆9-TETRAHYDROCANNABINOL 86 14.30 Bert Vanbilloen, Guy Bormans INDUCES INCREASED DOPAMINE and Koen Van Laere TRANSPORTER AVAILABILITY LYSOSOMAL DYNAMICS IN ∆9-TETRAHYDROCANNABINOL- Aoife Gowran 87 14.45 INDUCED APOPTOSIS IN RAT CORTICAL NEURONS Moises Garcia-Arencibia, Sara NEUROPROTECTION WITH Gonzalez, Eva de Lago, Jose Antonio CANNABINOIDS IN A RAT MODEL 15.00 Ramos, Raphael Mechoulam 88 OF PARKINSON’S DISEASE and Javier Fernandez-Ruiz

15.15 - 16.15 Coffee Break & Business Meeting

x Session 16: Non-Mammalian Organisms ¾ Chairs: Drs. John McPartland and Maurice Elphick SPECIES TREES AND GENE TREES 16.15 John McPartland AS METHODS FOR INFERRING 89 COEVOLUTION THE EVOLUTIONARY ORIGIN OF Maurice Elphick CANNABINOID RECEPTORS: EVIDENCE OF 16.30 AN ANCIENT ROLE IN PRESYNAPTIC 90 and Michaela Egertová REGULATION OF NEURONAL SIGNALLING IN INVERTEBRATE CHORDATES Athanasia Siafaka-Kapadai, Eleni MAGL 16.45 Farmaki, Alexandra Theodoridou (MONOACYLGLYCEROLIPASE) 91 and Dimitrios Anagnostopoulos ACTIVITY IN TETRAHYMENA

Poster Session 17.00 - 19.15 Sessions # 13 - 16

Hot and Controversial Issue Session #2:

18.45 – 19.15 “Pharmacology of Cannabidiol: Cannabinoid Receptors and Beyond” Chairs: Drs. Chris Fowler and Adèle Thomas

20.00 Dinner

Notes:

xi Day 1 – Sunday, June 25th 15.30 – 17.30 Poster Sessions # 2 & # 4

2. Receptor Structure and Signal Transduction Page # Eva V. Varga, Teodora Georgieva, Suneeta PLASMON WAVEGUIDE RESONANCE (PWR) Tumati, Zdzislaw Salamon, William R. SPECTROSCOPY: A NOVEL TOOL TO EXAMINE 92 Roeske, Gordon Tollin, Henry I. Yamamura CANNABINOID RECEPTOR SIGNALING

LIGAND-DEPENDENT ALTERATIONS IN CB1 Lisa S. , Michael P. Cassidy, RECEPTOR FUNCTION AND LOCALIZATION IN Dana E. Selley and Laura J. Sim-Selley 93 CB1 RECEPTOR-EXPRESSING CHO CELLS

E. Gkoumassi, M. J. Dröge, C.R.S. Elzinga, DUAL MODULATION OF ADENYLYL CYCLASE B. G. J. Dekkers, H. Meurs, J. Zaagsma BY CANNABINOIDS IN HUMAN BRONCHIAL 94 and S. A. Nelemans EPITHELIAL CELLS

Gábor Nyíri, Eszter Szabadits, Csaba THE NITRIC OXIDE SENSITIVE GUANYLYL CYCLASE ALPHA1 SUBUNIT IS ABUNDANT IN DIFFERENT Cserép, Javier Gracia-Llanes TYPES OF INTERNEURONS BUT NOT IN PYRAMIDAL 95 and Tamás F. Freund CELLS IN RAT HIPPOCAMPUS Gemma L. Baillie, Lesley A. Stevenson, ALLOSTERIC MODULATION OF THE CANNABINOID Adèle Thomas, Roger G. Pertwee CB1 RECEPTOR: AGONIST DEPENDENCE 96 and Ruth A. Ross DIFFERENTIAL REGULATION OF TYROSINE Barbara Bosier, Emmanuel Hermans HYDROXYLASE EXPRESSION IN NEUROBLASTOMA and Didier M.Lambert CELLS BY DISTINCT CANNABINOID CB1 RECEPTOR 97 AGONISTS

Irina A. Khasabova, Catherine Harding- ANANDAMIDE INHIBITS CALCIUM CHANNELS IN Rose, Donald A. Simone DORSAL ROOT GANGLION NEURONS INDEPENDENT 98 and Virginia S. Seybold OF CANNABINOID-1 RECEPTORS

Eleni Farmaki, Dimitrios Anagnostopoulos THE ENDOCANNABINOID SYSTEM IN RABBIT BRAIN. EVIDENCE FOR THE PRESENCE OF CB2 99 and Athanasia Siafaka-Kapadai RECEPTORS

Federico Massa, Krisztina Monory, Matthias Eder, Gerhard Rammes, Maria R. Domenici, ROLE OF CB1 IN DIFFERENT NEURONAL Shahnaz Azad, Walter Zieglgänsberger, SUBPOPULATION IN THE BRAIN 100 Giovanni Marsicano and Beat Lutz

Meliha Karsak, Jennifer Rehnelt, Edda EXPRESSION ANALYSES OF TWO HUMAN CB2 Erxlebe, Julia Essig, Itai Bab PROTEIN VARIANTS 101 and Andreas Zimmer

CELL SURFACE CB1 AND GPR55 ARE TARGETED TO Chris Henstridge, Neil McDonald, DISTINCT CELLULAR DOMAINS WHEN EXPRESSED Chris Connolly and Andrew Irving RECOMBINANTLY IN CULTURED HIPPOCAMPAL 102 NEURONS

ANANDAMIDE MODULATION OF CALCIUM Lesley Ford and Andrew Irving SIGNALLING IN CULTURED HIPPOCAMPAL 103 NEURONS AND GLIA

Ankur Kapur, Daniel Fleischer, Dow P. THE IMPORTANCE OF RESIDUES, S7.39 AND S2.60 IN Hurst, Patricia H. Reggio, Alexandros MODULATING THE FUNCTION OF THE HUMAN CB1 104 Makriyannis and Mary E. Abood CANNABINOID RECEPTOR

xii Zsuzsanna Sidlo, Patricia Reggio CB1-RECEPTOR DEPENDENT INHIBITION OF STRIATAL DOPAMINE RELEASE IS INDIRECT VIA 105 and Margaret Rice GABA RELEASE INHIBITION

PKC EPSILON NULL MICE SHOW ENHANCED Wallace MJ, Newton PM and Messing RO BEHAVIORAL RESPONSES TO CANNABINOIDS 106 Dow P. Hurst, Ruxandra C. Serbanescu, IN SILICO MODELING OF GPR55: CREATION OF AN Teresa S. Barber, Diane L. Lynch, Judy- INITIAL MODEL AND REFINEMENT BASED UPON 107 Barnett-Norris and Patricia H. Reggio SEQUENCE DIVERGENCES IN TMH6 AND TMH7 Ruxandra Serbanescu, Dow P. Hurst, CANNABINOID CB2 RECEPTOR CONSTITUTIVE Rundong Zhang, Zhao-Hui Song ACTIVITY MAY BE DUE TO LACK OF AROMATICITY 108 and Patricia H. Reggio AT RESIDUE 6.44 H. Ansanay, E. Trinquet, M. Fink, F. Grillet, F. Maurin, E. Bourrier, H. Bazin, N. Gregor, IP-ONE: A NEW HTRF® ASSAY TO MONITOR GQ- S. Sulocha, A. Michaud, J.L. Tardieu, C. COUPLED GPCR RESPONSE 109 Goudet, F. Malhaire, J.P. Pin, T. Durroux, D. Maurel, J. Bernard and E. Burgeon 4. Biosynthesis and Inactivation of Endocannabinoids and Related Lipids

Yasuo Okamoto, Jun Wang, Jun Morishita, PURIFICATION AND CHARACTERIZATION OF RECOMBINANT NAPE-PLD EXPRESSED IN 110 Kazuhito Tsuboi, and Natsuo Ueda ESCHERICHIA COLI Sandra Holt, Linda Boldrup, Anna Sundström, Maria Teresa Cocco, INHIBITION OF FATTY ACID AMIDE HYDROLASE BY ANALOGUES OF NONSTEROIDAL ANTI- 111 Valentina Onnis, Gunnar Tiger INFLAMMATORY DRUGS and Christopher J. Fowler Séverine Vandevoorde, Christine 3-NITRO-N-PENTADECYLBENZAMIDE IS A Hilligsmann, Natsuo Ueda, Didier TEMPLATE FOR SELECTIVE INHIBITORS OF 2- 112 M.Lambert and Christopher J. Fowler ARACHIDONOYLGLYCEROL METABOLISM PHARMACOLOGICAL CHARACTERIZATION OF THE Lina Thors and Christopher J. Fowler INITIAL AND TIME-DEPENDENT UPTAKE OF 113 ANANDAMIDE Katarzyna Starowicz, Luigia Cristino, ENDOVANILLOID DEGRADATION: COMPARATIVE Luciano De Petrocellis,Vittorio Guglielmotti ANALYSIS OF FAAH, COMT AND TRPV1 EXPRESSION 114 and Vincenzo Di Marzo IN THE MOUSE BRAIN Amy K. Dickason-Chesterfield, Stephanie R. PHARMACOLOGICAL CHARACTERIZATION OF Kidd, Steven A. Moore, John M. Schaus, Bin ANANDAMIDE UPTAKE AND FAAH INHIBITORS 115 Liu, George G. Nomikos and Christian C. Felder

Susanna M. Saario, Tapio Nevalainen, THE HYDROLYSIS OF 2-AG IN RAT CEREBELLAR MEMBRANES IS NOT INHIBITED BY A POTENT 116 Jarmo T. Laitinen and Tomi Järvinen MONOGLYCERIDE LIPASE INHIBITOR URB754 Dimitrios Anagnostopoulos, Ioannis Lykakis, ALL TRANS ANADAMIDE SYNTHESIS AND ITS Carla Ferreri, Chryssostomos Chatgilialoglu EFFECTS ON PLATELET FUNCTIONS. INTERFERENCE 117 and Athanasia Siafaka-Kapadai WITH CIS-ANANDAMIDE HYDROLYSIS BY FAAH

CELLULAR ACTIVITY AND LOCALIZATION OF Martin Kaczocha and Dale G. Deutsch FAAH-GFP FUSION PROTEINS 118

David K. O’Dell, Neta Rimmerman, Sarah FATTY ACYL AMIDES OF ENDOGENOUS TETRAHYDROISOQUINOLINES 119 R. Pickens and J. Michael Walker ARE TRPV1 ANATAGONISTS Annie Patel, J. Stephen Clark, Francis J.P. FURTHER CHARACTERISATION OF A Ebling, Michael J. Garle, David A. Kendall FLUORESCENCE-BASED ASSAY FOR FAAH 120 and Stephen P.H. Alexander ACTIVITY Stephen P.H. Alexander, Wayne G. Carter, A NOVEL FLUORESCENCE-BASED ASSAY FOR FAAH J. Stephen Clark, Tammy Lo ACTIVITY 121 and Michael J. Garle

xiii Day 2 – Monday, June 26th 15.00 – 17.15 Poster Sessions # 1, # 6 - 8 1. SAR Studies and New Synthetic Molecules

Alicia L. S. Thompson, John W. Huffman, DEOXY BICYCLIC COMPOUNDS AS POTENTIAL CB2 Jenny L. Wiley and Billy R. Martin SELECTIVE LIGANDS 122

Valerie J. Smith, John W. Huffman, Jenny EFFECTS OF HALOGEN SUBSTITUENTS UPON CB1 AND CB2 RECEPTOR AFFINITIES IN THE 1-ALKYL-3- 123 L. Wiley and Billy R. Martin (1-NAPTHOYL)INDOLE SERIES Tapio Nevalainen, Teija Parkkari, Outi DIMETHYLHEPTYL DERIVATIVES OF 2- M.H. Salo, Kristiina M. Huttunen, Juha R. ARACHIDONOYL GLYCEROL (2-AG) AND 2- Savinainen, Jarmo T. Laitinenb, ARACHIDONYL GLYCERYL ETHER (2-AGE): 124 Antti Poso, and Tomi Järvinen SYNTHESIS AND CB1 RECEPTOR ACTIVITY Michael J. Dart, Jennifer M. Frost, Karin R. 1-ALKYL-3-KETO-INDOLES: IDENTIFICATION AND Tietje, Anthony V. Daza, George K. Grayson, IN VITRO CHARACTERIZATION OF A SERIES OF Yihong Fan, Sutapa Mukherjee, Tiffany Runyan 125 POTENT CANNABINOID LIGANDS Garrison, Betty Bei Yao and Michael D. Meyer M.G. Cascio, T. Bisogno, E. Palazzo, A. IN VITRO AND IN VIVO PHARMACOLOGY OF Thomas, A. Brizzi, V. de Novellis, R. Pertwee, SYNTHETIC OLIVETOL-DERIVED CANNABINOID 126 V. Brizzi, S. Maione and V. Di Marzo RECEPTOR LIGANDS

Herbert H. Seltzman, Michael J. Roche, Marcus F. STUDIES TOWARDS ENHANCED BINDING AND Brackeen, Mary E. Abood, Daniel Fleischer, Deborah ACTIVITY OF NEUTRAL ANTAGONISTS FOR Lewis, Shangping Shi, Ester Fride, Nikolai Gobshtis, 127 Dow P. Hurst and Patricia H. Reggio THE CB1 RECEPTOR

M. Paola Castelli, Clementina Manera, DESIGN, SYNTHESIS AND BIOLOGICAL Veronica Benetti, Adriano Martinelli, A. EVALUATION OF NEW 1,8-NAPHTHYRIDIN-4(1H)-ON- 3-CARBOXAMIDE AND QUINOLIN-4(1H)-ON-3- 128 Paola Piras, Giuseppe Saccomanni, Tiziano CARBOXAMIDE DERIVATIVES AS CB2 SELECTIVE Tuccinardi and Alfredo Vannacci AGONISTS

Katerina Antoniou, George Panagis, Kyriaki Thermos, Maria Papazoglou, Niki Mastrodimou, Alexia PHARMACOLOGICAL PROFILE OF A NEW LIGAND Polissidis, Styliani Vlachou, Victoria Nahmias, 129 Michalis P. Kondylis, Dimitris Papahatjis, Zeta FOR CB1 AND CB2 CANNABINOID RECEPTORS Daifoti-Papadopoulou and Christina Spyraki Srinivas Gullapalli, Meyyappan Muthuppalaniappan, Abraham Thomas, Neelima Khairatkar-Joshi, NOVEL ORALLY ACTIVE CB2 RECEPTOR AGONISTS Kanthikiran Varanasi, Swaroop Kumar V.S. WITH POTENTIAL ANTI-HYPERALGESIC EFFECTS 130 Vakkalanka and Shridhar Narayanan 6. Nervous Function and Neuropsychiatric Disorders Lindsey Teasenfitz, Zoila Mora, Babatunde BEHAVIORAL EFFECTS OF CB2 CANNABINOID Akinshola and Emmanuel S. Onaivi RECEPTOR LIGANDS 131 CANNABINOIDS, SCHIZOPHRENIA AND GENDER PRENATAL EVENTS MODULATE CB1R AGONIST- Nikolai Gobshtis and Ester Fride INDUCED IMPAIRMENT OF PRE-PULSE INHIBITION 132 (PPI) DIFFERENTLY IN MALES AND FEMALES

Daniela Braida, Valeria Limonta, Simona INVOLVEMENT OF 5-HT1A SEROTONERGIC RECEPTOR ON ∆9-TETRAHYDROCANNABINOL (∆9- 133 Pegorini, Alessia Zani and Mariaelvina Sala THC)-INDUCED EMOTIONAL RESPONSE IN RATS Jenny L. Wiley, Seth H. Kendler, SEX DIFFERENCES IN SENSITIVITY TO James J. Burston, Dana E. Selley, ANTIPSYCHOTIC EFFECTS ON CANNABINOID CB1 134 and Laura J. Sim-Selley RECEPTOR FUNCTION IN RATS

xiv Daniel T. Malone, Christopher S. Kearn, EFFECT OF SOCIAL ISOLATION ON CB1, D2 AND Lily Chongue, Helen R. Irving, Ken Mackie FAAH EXPRESSION IN SPRAGUE-DAWLEY RATS 135 and David A. Taylor

Toshiyuki Kimura, Makiko Takaya, Satoshi CB1 RECEPTOR MEDIATES THE POTENTIATION OF Yamaori, Tatsuya Funahashi, Kazuhito PENTOBARBITAL-INDUCED SLEEP BY DELTA-9- 136 Watanabe and Ikuo Yamamoto TETRAHYDROCANNABINOL EFFECTS OF ADMINISTRATION OF THE CB1 Michelle Roche, Emer O’Connor, Catherine RECEPTOR ANTAGONIST SR141716A INTO THE RIGHT BASOLATERAL AMYGDALA ON 137 Diskin, John P. Kelly and David P. Finn CONDITIONED FEAR AND ASSOCIATED ANALGESIA IN RATS Realini N., Guidali C., Perletti G., ROLE OF ENDOCANNABINOIDS IN THE MODULATION OF ANXIOUS STATES IN RAT 138 Parolaro D. and T. Rubino PREFRONTAL CORTEX

Beáta Sperlágh, Tamás Balázsa, CHARACTERIZATION OF CANNABINOID RECEPTORS INVOLVED IN THE MODULATION OF [3H]5-HT 139 Nóra Gullai and E. Sylvester Vizi RELEASE FROM THE HIPPOCAMPUS

R.N. Takahashi, R.M. Bitencourt FACILITATION OF CONDITIONED-FEAR EXTINCTION BY I.C.V. ADMINISTRATION OF AM404, A POTENT 140 and F.A. Pamplona INHIBITOR OF ENDOCANNABINOID RE-UPTAKE 7. Nervous Function: Retrograde Signalling, Memory and Learning

Anushka V. Goonawardena, Gernot Riedel ACQUISITION OF AN INSTRUMENTAL OPERANT TASK IS FACILITATED FOLLOWING INTRA- 141 and Robert E. Hampson HIPPOCAMPAL INFUSION OF WIN 55, 212-2

Marianne El Khoury, Larissa Moutsimilli, THE CB1 RECEPTOR ANTAGONIST AM251 AMELIORATES COGNITIVE DEFICTS ASSOCIATED 142 Bruno Giros and Eleni T. Tzavara TO HYPERDOPAMINERGIA

Diana Dow-Edwards, Ning Zhao EARLY ADOLESCENT THC ALTERS BEHAVIOR IN and Stacy Stephenson AVOIDANCE PARADIGMS IN SEX-SPECIFIC WAYS 143

SPONTANEOUS CA2+ SPIKES IN DENDRITES OF CEREBELLAR PURKINJE CELLS TRIGGER 2- Michael J. Urbanski and Bela Szabo ARACHIDONOYLGLYCEROL-MEDIATED 144 RETROGRADE SYNAPTIC SIGNALING

Caroline Herron, Gemma Grennan, METABOTROPIC GLUTAMATE RECEPTOR MEDIATED LTD IN THE CA1 REGION: A ROLE FOR Ciara Dolan, John O’Connor THE LIPOXYGENASE PATHWAY AND 145 and Deirdre O’Leary ENDOCANNABINOIDS

Orsolya Magyar, Matthew N. Hill, DOSE DEPENDENT EFFECTS OF CANNABINOID CB1 Anna C. Morrish, Larissa M. Froese RECEPTOR ACTIVATION OR ANTAGONISM ON 146 and Stan B. Floresco BEHAVIORAL FLEXIBILITY 8. Pain and Inflammation

Michael Meyer, Gin Hsieh, Madhavi Pai, Chang Zhu, A-796260: A CB2-SELECTIVE FULL AGONIST Prasant Chandran, Prisca Honore, Michael Dart, EXHIBITING ANALGESIC ACTIVITY IN RODENT Jennifer Frost, Tony Daza, George Grayson, Sutapa 147 Mukherjee, Yihong Fan and Betty Yao MODELS OF NOCICEPTIVE PAIN

xv EFFECT OF THE CANNABINOID CB1 RECEPTOR Elena Zarini ANTAGONIST RIMONABANT ON NOCICEPTIVE and Tiziano Croci RESPONSE AND SEVERITY OF ADJUVANT-INDUCED 148 ARTHRITIS IN OBESE AND LEAN RATS

Penny C. Staton, Jon P. Hatcher, Alastair D. Morrison, DETERMINING THE ROLE OF A THIRD Debbie J. Walker, Mike Parsons, Andrew J. Brown, CANNABINOID RECEPTOR, GPR55, IN Alan Wise, Jane P Hughes, Paula Green, 149 Jill C. Richardson and Iain P. Chessell INFLAMMATORY AND NEUROPATHIC PAIN

Francesca Comelli, Mariapia Colleoni, EFFECT OF A CANNABIS SATIVA EXTRACT ON NOCICEPTIVE BEHAVIOUR IN A RAT MODEL 150 Gabriella Giagnoni and Barbara Costa OF NEUROPATHIC PAIN

Betty Bei Yao, Bradley A. Hooker, Madhavi Pai, Prasant Chandran, Anita Salyers, Chang Z. Zhu, DORSAL ROOT GANGLIA (DRG) AND SPINAL CORD Gin Hsieh, Prisca Honore, Xiaoan Ruan, Paul AS THE SITES OF ACTION FOR CB2 RECEPTOR 151 Kroeger, Jennifer Frost, Michael Dart MEDIATED ANALGESIC ACTIVITIES and Michael Meyer

Mahmoud Al-Khrasani, Tamas Friedmann, Pal THE ROLE OF CANNABINOID CB1 RECEPTORS IN Riba, Kornel Király, László Köles, PAIN THRESHOLD OF MICE STUDIED IN CHEMICAL 152 Tibor Wenger, Klára Gyires and Susanna Fürst AND THERMAL PAIN

Elizabeth J. Rahn, Alexandros CANNABINOIDS SUPPRESS CHEMOTHERAPY- EVOKED PAINFUL NEUROPATHY THROUGH 153 Makriyannis and Andrea G. Hohmann ACTIVATION OF CB1 AND CB2 RECEPTORS

Yasuhide Morioka, Hiroyuki Kai, Takami Murashi, Minoru Tomida, Hideyuki Takenaka, Maki Hattori, Fumiyo Takahashi, Shin-ichi Mihara, Keiko Kawamoto, Kohji NOVEL CANNABINOID RECEPTOR AGONISTS : Hanasaki, Tohko Arai, Kohji Abe, Katsumi Koike, Hiroki IN VITRO AND IN VIVO CHARACTERIZATION OF 154 Chiba, Shunji Shinohara, Toshiyuki Kanemasa, Hiroshi IMINOTHIAZINE DERIVATIVES Okabe,Yuka Iwamoto, Kohji Takahashi, Yoshitaka Yamaguchi, Takahiko Baba and Takayoshi Yoshikawa Enza Palazzo, Vito de Novellis, Ida Marabese, Tiziana Bisogno, Francesco REPEATED TREATMENT WITH SELECTIVE INHIBITORS OF THE ENZYME FATTY-ACID AMIDE 155 Rossi, Maria Antoinetta Scafuro, HYDROLASE ALLEVIATES NEUROPATHIC PAIN Vincenzo Di Marzo and Sabatino Maione

Stefania Petrosino, Enza Palazzo, CHANGES IN ENDOCANNABINOID AND PALMITOYLETHANOLAMIDE LEVELS IN CENTRAL Vito de Novellis, Sabatino Maione AND PERIPHERAL NERVOUS SYSTEMS 156 and Vincenzo Di Marzo IN AN ANIMAL MODEL OF NEUROPATHIC PAIN

Sauro Lorenzini, Enrico Selvi, Estrella Garcia-Gonzalez, Roberta Maggio, Epifania Balistreri, Pietro Enea Lazzerini, CANNABINOID RECEPTORS CB1 AND CB2 Pier Leopoldo Capecchi, Adriano Spreafico, Gerarda EXPRESSION BY OSTEOARTRITHIC AND 157 Pompella, Maria Rita Natale, Franco Laghi Pasini, RHEUMATOID FIBROBLAST-LIKE SYNOVIOCYTES Mauro Galeazzi and Roberto Marcolongo

IMMUNOLOCALISATION OF THE ANANDAMIDE I.J. Lever, K. Masuda, B.F. Cravatt DEGRADING ENZYME: FATTY ACID AMIDE and A.S.C. Rice HYDROLASE (FAAH) IN RAT DORSAL ROOT 158 GANGLION AND SPINAL CORD TISSUE

CHRONIC DELIVERY OF WIN55,212-2 TO THE SITE OF I. J. Lever and A.S.C. Rice A PERIPHERAL NERVE INJURY ATTENUATES 159 MECHANICAL AND COLD ALLODYNIA

Sherrye T. Glaser, Andrew N. Gifford IMMUNOLOCALIZATION OF THE ENDOCANNABINOID AND PROSTAGLANDIN 160 and S. John Gatley SYSTEMS IN THE MOUSE SPINAL CORD

THE EFFECT OF THE TRPV1 RECEPTOR Gyöngyi Horvathi, Gabriella Kekesi ANTAGONIST, CAPSAZEPINE ON THE 161 and György Benedek ANTINOCICEPTIVE POTENCY OF ANANDAMIDE AT SPINAL LEVEL xvi 15.30 - th 18.15 Day 3 – Tuesday, June 27

Poster Sessions # 9 - 12 9. Food Intake and Energy Balance

Dana Kevin Sindelar, John Schaus, Stephen Hitchcock, Amy NEUROPSYCHOPHARMACOLOGICAL CHARACTERIZATION OF A Porter, Jennifer Allen, Winton Jones, Robert Stratford, Henry SULFONAMIDE COMPOUND [4-(3-CYCLOPENTYL-INDOLE-1- Havel, Eyassu Chernet, Lee Phebus, John Hart, Jesline SULFONYL)-N-(TETRAHYDRO-PYRAN-4-YLMETHYL)-BENZAMIDE], 162 Alexander-Chacko, Xia Li, Richard Davis, David McKinzie, AS A NOVEL, POTENT, SELECTIVE AND ORALLY Jeffrey Witkin and George Nomikos ACTIVE CB1 CANNABINOID RECEPTOR ANTAGONIST M. Maccarrone, B. Spoto, G. Parlongo, N. THE ENDOCANNABINOID SYSTEM IN HUMAN Battista, E. Sgro’, A. Finazziagrò ADIPOSE TISSUE FROM HEALTHY SUBJECTS 163 and C. Zoccali. Patrizia Gazzerro, Maria Gabriella Caruso, Maria Notarnicola, Giovanni Misciagna, ASSOCIATION BETWEEN CANNABINOID TYPE-1 RECEPTOR POLYMORPHISM AND BODY MASS 164 Vito Guerra, Chiara Laezza INDEX IN A SOUTHERN ITALY POPULATION and Maurizio Bifulco Gitte Petersen, Camilla Sørensen, Patricia C. INTESTINAL LEVELS OF ANANDAMIDE AND Schmid, Andreas Artmann, Mads Tang- OLEOYLETHANOLAMIDE IN FOOD-DEPRIVED RATS Christensen, Steen H. Hansen, Philip J. Larsen, 165 ARE REGULATED THROUGH THEIR PRECURSORS Harald H. O. Schmid and Harald S. Hansen Sevasti Karaliota, Alexandra Gountopoulou, Chrysanthi Gondinou, ANANDAMIDE INDUCES THE DIFFERENTIATION OF RAT PREADIPOCYTES THROUGH THE 166 Athanasia Siafaka-Kapadai INDUCTION OF PPARγ and Mary Mavri-Vavayanni 10. Immune System

LaToya A. Griffin and Guy A. Cabral CANNABINOIDS ALTER NFκB BINDING IN MICROGLIA 167

Manop Buranapramest and Nancy E. EFFECTS OF WIN 55,212-2 ON CD4+ T-CELL PROLIFERATION AND CYTOKINE SECRETION AT 168 Buckley NANOMOLAR CONCENTRATIONS

Anna Maria Malfitano, Gokce Altay Toruner, Chiara Laezza, ARVANIL AND ANANDAMIDE UP-REGULATE CD36 Seema Husain, Patrizia Gazzerro, Davide Eletto, Pierangelo , Luciano De Petrocellis, Alexandra Terskiy, Marvin EXPRESSION IN HUMAN PERIPHERAL BLOOD 169 Schwalb, Emilia Vitale and Maurizio Bifulco MONONUCLEAR CELLS 11. Cardiovascular, Gastrointestinal and Other Peripheral Functions Javier Fernández Solari, Juan Pablo Prestifilippo, Paula Vissio, Samuel M. THE ACTIVATION OF CENTRAL CANNABINOID McCann, Valeria Rettori RECEPTORS INHIBITS SALIVARY SECRETION 170 and Juan Carlos Elverdin Juan Pablo Prestifilippo, Javier Fernández Solari, Juan Carlos Elverdin, Angela LIPOPOLYSACCHARIDE (LPS) ACTIVATES THE ENDOCANNABINOID SYSTEM IN THE 171 Suburo, Samuel M. McCann SUBMANDIBULARY GLAND OF THE RAT and Valeria Rettori RELAXATION OF THE GASTROINTESTINAL TRACT Nina L. Cluny, Farideh A. Javid, OF SUNCUS MURINUS INDUCED BY Brian Whittle and Robert J. Naylor CANNABIDIOLIC ACID (CBDA) 172 AND CANNABIDIOL (CBD)

xvii STUDIES ON THE RECEPTORS MEDIATING K Skene, C. Stewart, D Middleton, RELAXANT RESPONSES TO THE R.G Pertwee and C. L Wainwright ENDOCANNABINOID ANANDAMIDE IN THE 173 PORCINE CORONARY ARTERY

W.-S. Vanessa Ho, Matthew N. Hill, Boris CORRELATIONS BETWEEN SERUM CONTENTS OF B. Gorzalka, Cecilia J. Hillard ENDOGENOUS CANNABINOIDS AND BLOOD 174 and Gregory E. Miller PRESSURE IN WOMEN WITH DEPRESSION

Nashwan Shujaa, Zoltán Zádori, CANNABINOID CB1 RECEPTORS MAY MEDIATE GASTRIC MUCOSAL PROTECTION AND INHIBITION Al-Khrasani, Matteo Rossi, Susanna Fürst, OF STIMULATED GASTRIC MOTILITY 175 Tibor Wenger and Klara Gyires IN RATS AND MICE

VASCULAR EFFECTS OF O-1918, A PUTATIVE P. M. Hoi and C. R. Hiley RECEPTOR ANTAGONIST AT A NOVEL 176 CANNABINOID RECEPTOR

Manoj Kanichai, Aoife Gowran CANNABINOID-MEDIATED REGULATION OF ADULT RAT MESENCHYMAL STEM CELL DIFFERENTIATION 177 and Veronica Campbell ALONG THE OSTEOGENIC LINEAGE

STUDIES ON THE EFFECTS OF ABNORMAL N. Silva, R.M. Knott, R.G. Pertwee CANNABIDIOL AND THE CB1 AGONIST ACEA ON and C. L Wainwright VASCULAR FUNCTION AND SMOOTH MUSCLE CELL 178 GROWTH IN THE PORCINE CORONARY ARTERY

Slavko Tokanovic, Daniel T. Malone THE EFFECT OF CANNABINOIDS ON SMOOTH and Sabatino Ventura MUSCLE CONTRACTILITY OF THE RAT PROSTATE 179

Mauro A.M. Carai, Giancarlo , Gian ARE CANNABINOID CB1 AND OPIOID RECEPTORS Luigi Gessa, Ratnakumar Yalamanchili, Balapal RELATED IN THE CONTROL OF GASTROINTESTINAL 180 S. Basavarajappa and Basalingappa L. Hungund MOTILITY IN MICE?

Kent-Olov Jonsson, Ulf H. Lerner REGULATION OF OSTEOTROPIC CYTOKINE EXPRESSION IN OSTEOBLASTS BY THE 181 and Emma Persson ENDOCANNABINOID ANANDAMIDE

William R. Sones, Mike E. Parsons CANNABINOID MODULATION OF VOLTAGE-GATED CALCIUM CHANNELS IN GUINEA-PIG 182 and Areles Molleman MYENTERIC NEURONS

Ana Franchi, Julieta Aisemberg, Silvia EFFECT OF ANANDAMIDE (AEA) AND Billi, María L. Ribeiro, LIPOPOLYSACCHARIDE (LPS) 183 and Claudia Vercelli ON EARLY MURINE PREGNANCY

KL Wright , DA Medina-Tato, CANNABINOIDS INFLUENCE THE VIABILITY OF DAF Robertson, MP Moyer and SG Ward NORMAL HUMAN COLONIC EPITHELIAL CELLS 184

Esperanza Herradón, Nuria González, EFFECTS OF WIN 55,212-2 IN RAT ISOLATED HEARTS M. Isabel Martín SUBJECTED TO ISCHAEMIA-REPERFUSION 185 and Visitación López-Miranda 12. Human and Clinical Studies

SURVEY OF MEDICINAL CANNABIS USE AMONG Philippe Lucas, Rachel E. Westfall, Patricia CHILDBEARING WOMEN: PATTERNS OF ITS USE IN A. Jannsen and Rielle Capler PREGNANCY AND RETROACTIVE SELF-ASSESSMENT OF 186 ITS EFFICACY AGAINST ‘MORING SICKNESS’

xviii Antonio W. Zuardi, Daniel C. Bosi, Jaime A SINGLE DOSE OF CBD REDUCES THE E.C.Hallak, Serdar M.Dursun DISSOCIATIVE EFFECTS PROVOKED BY (S)- 187 and John F.W. Deakin KETAMINE IN HEALTHY VOLUNTEERS

Zlatko Mehmedic, Suman Chandra, Don STABILITY OF DELTA-9-THC Stanford, Heather Levanduski, AND OTHER CANNABINOIDS 188 Ikhlas Khan and Mahmoud A. ElSohly IN DIFFERENT CANNABIS PRODUCTS David A. Gorelick, Marc L. Copersino, INFLUENCE OF DEMOGRAPHIC Susan J. Boyd, Donald P. Tashkin, Marilyn CHARACTERISTICS ON QUITTING OF A. Huestis, Stephen J. Heishman, 189 CANNABIS SMOKING Michael S. Simmons and John C. Dermand Dana C. Hammell, Raj K. Razdan, HUMAN SKIN PERMEATION OF JWH-203 AND John W. Huffman, Billy R. Martin O-2426, TWO SYNTHETIC CANNABINOIDS 190 and Audra L. Stinchcomb

USE OF SELF-REPORT AND URINE DRUG Aimee L. McRae, Rickey E. Carter SCREEN RESULTS IN CLINICAL RESEARCH and Kathleen T. Brady 191 WITH MARIJUANA-DEPENDENT INDIVIDUALS

CASE REPORT: INSOMNIA LEADING Tod H. Mikuriya TO IATROGENIC ILLNESS 192

Rebecca M. Maertens, Paul A. White, David THE RELATIVE TOXICITY, MUTAGENIC Moir, William Rickert, Genevieve Levasseur, ACTIVITY AND CHEMICAL COMPOSITION OF 193 George R. Douglas and Suzanne Desjardins TOBACCO AND CANNABIS SMOKE

17.00 - th 19.15 Day 4 – Wednesday, June 28

Poster Sessions # 13 - 16 13. Reward and Abuse Hiroki Ishiguru, Shinya Iwasaki, Lindsey INVOLVEMENT OF CANNABINOID CB2 Teasenfitz, Susumu Higuchi RECEPTOR IN MICE ALCOHOL PREFERENCE 194 and Emmanuel Onaivi AND IN HUMAN ALCOHOLISM Alain Pério, Cédrick Lachaud, Roselyne Calassi, INHIBITION BY SR147778 OF ETHANOL Michèle Fournier, Hélène Lacroix, Veronique CONSUMPTION ELICITED IN RATS AND MICE 195 Menet, Richard Alonso and Guy Griebel BY SCHEDULE-INDUCED POLYDIPSIA Tünde Molnár, Zsuzsa Emri, Edit Simon- SUCCINATE ACTS ON BACLOFEN-INSENSITIVE Trompler, Miklós Palkovits GHB RECEPTORS IN THE NUCLEUS 196 and Julianna Kardos ACCUMBENS ADOLESCENT EXPOSURE TO CANNABINOIDS Castiglioni C, Cherubino F, Rubino T, Fesce R, AND LONG TERM CONSEQUENCES ON THE Limonta V. and Parolaro D 197 ADULT BEHAVIOUR THE SITES OF SYNTHESIS AND ACTION OF Ferenc Mátyás, Masahiko Watanabe, Tamás F. ENDOCANNABINOIDS IN THE NUCLEUS Freund and István Katona 198 ACCUMBENS

MEDIAL FOREBRAIN BUNDLE STIMULATION Giuliano Pillolla, Simona Perra, Miriam Melis, Anna Lisa Muntoni and Marco Pistis EVOKES ENDOCANNABINOID-MEDIATED 199 EFFECTS ON DOPAMINE NEURONS IN VIVO

xix THE CANNABINOID RECEPTOR ANTAGONIST Simona Perra, Giuliano Pillolla, Miriam Melis, SR141716A BLOCKS THE INHIBITORY ACTIONS Anna Lisa Muntoni and Marco Pistis OF ALCOHOL ON BASOLATERAL AMYGDALA 200 PROJECTION NEURONS IN VIVO. Liana Fattore, Paola Fadda, M. Sabrina Spano, ENHANCEMENT OF DOPAMINE LEVELS IN THE Maria Scherma, Valeria Melis, Paola Salis RAT NUCLEUS ACCUMBENS SHELL DURING 201 and Walter Fratta WIN 55,212-2 SELF-ADMINISTRATION

Mauro A.M. Carai, Alessandro Orrù, Paola Lai, ∆9-THC STIMULATES ALCOHOL INTAKE IN Paola Maccioni, Carla Lobina, 202 Gian Luigi Gessa and Giancarlo Colombo ALCOHOL-PREFERRING SP RATS RIMONABANT AMELIORATES Marina Rubio, Rosario de Miguel, Maribel NEUROCHEMICAL UNBALANCE AND Cebeira, Javier Fernández-Ruiz 203 and José A. Ramos BEHAVIORAL SYMPTOMS OCCURRING DURING ALCOHOL WITHDRAWAL José Antonio López-Moreno, Francisco Alen, NICOTINE-INDUCED RELAPSE TO ALCOHOL Gustavo González-Cuevas, Raquel Gómez de AND THE NEW SPECIFIC CANNABINOID CB1 Heras, Inmaculada Crespo, Guillermo Moreno 204 and Miguel Navarro RECEPTOR ANTAGONIST SR147778 CANNABINOIDS MODULATE SYNAPTIC Caroline Herron and Franck TRANSMISSION IN THE RAT 205 NUCLEUS ACCUMBENS IN VIVO 14. Cancer

Eva de Lago, Stig O.P. Jacobsson, Marta San ANANDAMIDE UPTAKE INHIBITORS AFFECT Celestino Carchenilla, CELL PROLIFERATION AND CAUSE CALCIUM Javier Fernández-Ruiz, Jonas Nilsson 206 and Christopher J. Fowler INFLUX INTO C6 GLIOMA CELLS

Chiara Laezza, Simona Pisanti, Elvira Crescenzi, ANANDAMIDE ARRESTS CELL CYCLE Claudia Grimaldi,Annamaria Malfitano, Patrizia PROGRESSION IN MDA-MB-231 HUMAN Gazzerro, Antonietta Santoro, Gennaro Chiappetta, BREAST CANCER CELLS THROUGH INHIBITION 207 Emilia Vuttoriello and Maurizio Bifulco OF CDK2 ACTIVITY AND CHK1 ACTIVATION INVESTIGATION OF CB1 AS A POTENTIAL Susanne Oesch and Beat W. Schäfer DRUG TARGET IN ALVEOLAR 208 RHABDOMYOSARCOMA ANANDAMIDE RECEPTOR MEDIATED MATRIX Shanda Perry, Inneke Johnson METALLOPROTEASE ACTIVITY IN TUMOR CELLS IS and Somnath Mukhopadhyay PARTIALLY MEDIATED BY NITRIC OXIDE AND NEGATIVELY 209 REGULATED BY HETEROTRIMERIC GI PROTEIN 15. Neuroprotection CYTOTOXIC EFFECTS OF CANNABINOIDS ON Sofia B. Gustafsson, Anders Wallenius UNDIFFERENTIATED AND RETINOIC ACID- and Stig O. P. Jacobsson 210 INDUCED P19 EMBRYONAL STEM CELLS CANNABINOID CB1 RECEPTOR ACTIVATION Esposito Giuseppe, De Filippis Daniele, Bisogno INHIBITS MPTP-INDUCED EXPRESSION OF Tiziana, Steardo Luca, S100B IN GLIAL CELLS THEREBY LEADING TO 211 Di Marzo Vincenzo and Iuvone Teresa SURVIVAL OF CO-CULTURED NEURONS CANNABIDIOL INHIBITS INDUCIBLE NITRIC OXIDE Giuseppe Esposito, Daniele De Filippis, Maria SYNTHASE PROTEIN EXPRESSION AND NITRIC Chiara Maiuri, Daniela De Stefano, OXIDE PRODUCTION IN β-AMYLOID STIMULATED 212 Rosa Carnuccio and Teresa Iuvone PC12 NEURONS THROUGH P38 MAP KINASE AND NF-κB INVOLVEMENT Mauro Maccarrone, Diana Amantea, Paola MODULATION OF THE ENDOCANNABINOID Spagnuolo, Monica Bari, Filomena Fezza, SYSTEM IS INVOLVED IN ESTROGEN- 213 Cristina Tassorelli, Tiziana M. Corasaniti MEDIATED NEUROPROTECTION AGAINST and Gigi Bagetta FOCAL BRAIN ISCHEMIA

xx Anikó Ludányi, Sára Nagy, Zoya Katarova, SPECIFIC CHANGES IN 2-ARACHIDONOYL- Loránd Erőss, Sándor Czirják, János Vajda, GLYCEROL MEDIATED ENDOCANNABINOID Péter Halász, Gábor Szabó, Ken Mackie, SIGNALLING AT EXCITATORY SYNAPSES IN 214 Masahiko Watanabe, István Katona, TEMPORAL LOBE EPILEPTIC PATIENTS Tamás F. Freund and Zsófia Maglóczky

Simona Pegorini, Daniela Braida, Valeria AM 404 LEADS TO NEUROPROTECTION AGAINST Limonta, Alessia Zani and Mariaelvina Sala ISCHEMIA-INDUCED NEURONAL INJURY 215

Fernández-López D, Lizasoain I, Núñez E, SIMULTANEOUS CB1 AND CB2 RECEPTORS ACTIVATION SHOWS A SYNERGIC NEUROPROTECTIVE EFFECT AFTER Romero J, Lorenzo P, Moro MA OXYGEN AND GLUCOSE DEPRIVATION IN 7-DAY-OLD RAT 216 and Martínez-Orgado JA FOREBRAIN SLICES

Ronald F. Tuma, Ming Zhang, Billy R Martin, CB2 RECEPTOR ACTIVATION ATTENUATES Raj K. Razdan, Eli Baron, Martrin W. Adler CEREBRAL ISCHEMIA/REPERFUSION INJURY 217 and Jack Jallo

Yan Sun, Andrew Bennett, Steve Alexander, PPARα-MEDIATED NEUROPROTECTION BY 218 Claire Gibson and David Kendall OLEOYLETHANOLAMIDE

Matilda Degn, Kate Lykke Lambertsen, Gitte REGULATION OF FATTY ACID AMIDE HYDROLASE Petersen, Michael Meldgaard, Andreas Artmann, AND N-ACYLPHOSPHATIDYLETHANOLAMINE Steen Honoré Hansen, Bente Finsen, PHOSPHOLIPASE D IN FOCAL CEREBRAL ISCHEMIA 219 Harald S Hansen and Trine Meldgaard Lund IN MICE

CHANGES IN THE DISTRIBUTION OF SOME E. Núñez, R. Jones, R.M. Tolón, C. Benito, ELEMENTS OF THE ENDOGENOUS CANNABINOID M.R. Pazos, S. Griffin and J. Romero 220 SYSTEM IN DOWN’S SYNDROME

CANNABIDIOL REDUCED THE STRIATAL ATROPHY Onintza Sagredo, Alessandra Decio, José A. CAUSED 3-NITROPROPIONIC ACID IN VIVO BY Ramos, Ana Cabranes, Raphael Mechoulam MECHANISMS INDEPENDENT OF THE ACTIVATION 221 and Javier Fernández-Ruiz OF CANNABINOID RECEPTORS

THE ACTIVATION OF CANNABINOID CB2 RECEPTOR M.R. Pazos, E. Núñez, J.P. Romero, C.Benito, IMPAIRS Αβ REMOVAL FROM ALZHEIMER´S R.M. Tolón and J. Romero 222 DISEASE HUMAN TISSUES K Monory, F Massa, M Egertová, H Blaudzun, THE ENDOCANNABINOID SYSTEM CONTROLS A R Westenbroek, M Ekker, J Rubenstein, M KEY EPILEPTOGENIC CIRCUIT IN THE During, M Klugmann, W Kelsch, CT Wotjak, K 223 HIPPOCAMPUS Mackie, MR Elphick, G Marsicano and B Lutz

Katherine W. Falenski, Robert E. Blair, HIPPOCAMPAL CANNABINOID CB1 RECEPTOR Anne J. Harrison, Melisa J. Wallace, REDISTRIBUTION IN EPILEPTIC RAT BRAIN IS DEPENDENT Laura J. Sim-Selley, ON NMDA RECEPTOR ACTIVATION AND INDEPENDENT OF 224 Billy R. Martin and Robert J. DeLorenzo ONGOING SEIZURE ACTIVITY

Vincenzo Di Marzo, Nina Wettschureck, Mario DIFFERENTIAL CONTROL BY GQ/G11 PROTEINS OF van der Stelt, Hiroshi Tsubokawa, Alexandra IN VIVO ENDOCANNABINOID LEVELS AND Moers, Heinz Krestel, Stefania Petrosino, ENDOCANNABINOID-MEDIATED REGULATION OF 225 Günther Schütz and Stefan Offermanns NEURONAL EXCITABILITY 16. Non-Mammalian Organisms

CONCENTRATIONS OF ∆9-TETRAHYDROCANNABINOLIC ACID DURING M. de Wit, L. Saddik and S.F.A.J. Horsten GROWTH AND DEVELOPMENT OF 226 CANNABIS PLANTS

xxi