Therapeutic Class Overview Attention Deficit/Hyperactivity Disorder (ADHD) Agents
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Title Page Adrenergic Storm-Induced Warburg Effect in COVID-19
Title Page Adrenergic storm-induced Warburg effect in COVID-19: A hypothesis. Natesan Vasanthakumar School of Chemical and Biotechnology, SASTRA University, Thanjavur, Tamil Nadu, 613401, India. Corresponding author: Natesan Vasanthakumar, MD School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamil Nadu, 613401, India. Email: [email protected]; Telephone: +91-6380831065 Current address: Natesan Vasanthakumar, MD Sagol Department of Neurobiology, University of Haifa, Israel. 3498838 Email: [email protected] Telephone: +91-6380831065 Word count: 1586 Declaration: Dr. Vasanthakumar has nothing to disclose. The author did not receive any funding. Abstract: At present, there is no treatment option available for COVID-19 condition and most importantly the underlying pathophysiology in COVID-19 is not known. No theory at present explains all the clinical features in COVID-19. In this article, I had proposed a hypothesis that explains the underlying pathophysiology in COVID-19 and based on it proposed treatment options for COVID-19. I propose that the adrenergic storm-induced Warburg effect (aerobic glycolysis) may be the underlying mechanism in the COVID-19 condition. I propose alpha1 adrenergic blockers in the early phase and beta-adrenergic blockers in the late phase of COVID-19 to inhibit the adrenergic storm and reverse the Warburg effect in COVID-19 condition. Keywords: COVID-19, SARS-CoV-2, Adrenergic storm, Warburg effect, Aerobic glycolysis, alpha1 adrenergic blockers, beta adrenergic blockers. Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection caused coronavirus disease 2019 (COVID-19) pandemic is causing damage all over the world. It is known that SARS-CoV-2 enters the host cell via angiotensin-converting enzyme 2 (ACE2) and CD147, which is also known as Basigin or extracellular matrix metalloproteinase inducer (EMMPRIN )1,2. -
Optum Essential Health Benefits Enhanced Formulary PDL January
PENICILLINS ketorolac tromethamineQL GENERIC mefenamic acid amoxicillin/clavulanate potassium nabumetone amoxicillin/clavulanate potassium ER naproxen January 2016 ampicillin naproxen sodium ampicillin sodium naproxen sodium CR ESSENTIAL HEALTH BENEFITS ampicillin-sulbactam naproxen sodium ER ENHANCED PREFERRED DRUG LIST nafcillin sodium naproxen DR The Optum Preferred Drug List is a guide identifying oxacillin sodium oxaprozin preferred brand-name medicines within select penicillin G potassium piroxicam therapeutic categories. The Preferred Drug List may piperacillin sodium/ tazobactam sulindac not include all drugs covered by your prescription sodium tolmetin sodium drug benefit. Generic medicines are available within many of the therapeutic categories listed, in addition piperacillin sodium/tazobactam Fenoprofen Calcium sodium to categories not listed, and should be considered Meclofenamate Sodium piperacillin/tazobactam as the first line of prescribing. Tolmetin Sodium Amoxicillin/Clavulanate Potassium LOW COST GENERIC PREFERRED For benefit coverage or restrictions please check indomethacin your benefit plan document(s). This listing is revised Augmentin meloxicam periodically as new drugs and new prescribing LOW COST GENERIC naproxen kit information becomes available. It is recommended amoxicillin that you bring this list of medications when you or a dicloxacillin sodium CARDIOVASCULAR covered family member sees a physician or other penicillin v potassium ACE-INHIBITORS healthcare provider. GENERIC QUINOLONES captopril ANTI-INFECTIVES -
Roll-In NCT Number: NCT02841241 Date of Document: 12/16/2016 ECASSS-ROLL-IN V3 12-16-16
Cover Page Official Title: Esmolol to Control Adrenergic Storm in Septic Shock - Roll-in NCT Number: NCT02841241 Date of Document: 12/16/2016 ECASSS-ROLL-IN V3 12-16-16 Consent Form What Esmolol to Control Adrenergic Storm in Septic Shock (ECASSS) – ROLL-IN Where Intermountain Medical Center Who PI: Samuel Brown, MD, MS (801) 507-6556 Co- investigators: Colin Grissom, MD Michael Lanspa, MD, MS Emily Wilson, MS Ithan Peltan, MD Ellie Hirshberg, MD Peter Crossno, MD Vivian Lee, MD Sarah Beesley, MD Samir Parikh, MD Sponsor: Intermountain Medical Center When Your participation will last until you are discharged from the hospital. Why This research study will evaluate the adequacy and efficiency of study protocols for the main ECASSS study. We are investigating a drug called esmolol as a treatment for serious infection (“septic shock”). How While you are receiving infusions of medicines like adrenalin to support your blood pressure, we will infuse a medication called esmolol that we think will help to control the negative effects of the body’s high stress state during serious infection. You will also have some blood drawn and have ultrasound pictures of your heart taken. We will monitor to see how long it takes for your body to improve from the serious infection. Page 1 of 12 Intermountain Healthcare IRB IRB NUMBER: 1050147 IRB APPROVAL DATE: 01/16/2017 IRB EXPIRATION DATE: 12/07/2017 ECASSS-ROLL-IN V3 12-16-16 Why is this study being done? We are asking you to take part in a research study about a drug called esmolol for use in septic shock. -
Manuscript for Discussant
Original article BETA-BLOCKER THERAPY IN SEVERE TRAUMATIC BRAIN INJURY: A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL Short title: Beta-blocker in severe TBI Hosseinali Khalili MD; Rebecka Ahl MB BChir, Ph.D; Shahram Paydar MD; Gabriel Sjolin MD; Yang Cao, Ph.D; Hossein Abdolrahimzadeh Fard MD; Amin Niakan MD; Kamil Hanna MD; Bellal Joseph MD; Shahin Mohseni MD, Ph.D. Author Contact Information: Hosseinali Khalili, MD. Associate Professor of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran Email: [email protected] Dr Rebecka Ahl, MB BChir, PhD. General Surgery Resident Department of Surgery, Karolinska University Hospital, Stockholm, Sweden Email: [email protected] Shahram Paydar, MD. Associate Professor of Surgery Trauma Research Center, Rajaee (emtiaz) trauma hospital, Shiraz University of Medical Sciences, Shiraz, Iran Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran Email: [email protected] Gabriel Sjolin, MD. Department of Surgery, Orebro University Hospital, 701 85 Orebro, Sweden School of Medical Sciences, Orebro University, 702 81 Orebro, Sweden Email: [email protected] Yang Cao, PhD. Professor of Epidemiology and Biostatistics Clinical Epidemiology and Biostatistics, School of Medical Sciences, Orebro University, Orebro 70182, Sweden Email: [email protected] Amin Niakan, MD. Assistant Professor of Neurosurgery, Trauma Research Center, Shahid Rajaee (Emtiaz) Trauma Hospital, Department of Neurosurgery, Shiraz University of Medical Sciences, Shiraz, Iran Email: [email protected] Hossein Abdolrahimzadeh Fard, MD. Assistant Professor of Surgery Trauma Research Center, Rajaee (emtiaz) trauma hospital, Shiraz University of Medical Sciences, Shiraz, Iran Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran Email: Dr.h.a.fard@gmail Kamil Hanna, MD. -
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role of CALCIUM CHANNEL BLOCKERS in HYPERTENSION KEY POINTS ThIAZIDES ARE APPROPRIATE INITIAL THERAPY FOR MOST PEOPLE WITH HYPERTENSION Thiazides are appropriate initial therapy for most ▪ There is limited evidence of superiority of one antihypertensive people with hypertension. over another but evidence suggests that for most patients, ▪ Choice of other antihypertensives is decided by diuretics can be considered first, based on their effectiveness, individual patient factors. safety and low cost. ▪ Factors which potentially favour use of calcium channel blockers include arrhythmia (verapamil CHOICE OF ADDITIONAL ANTIHYPERTENSIVES only), angina, older age and high risk of stroke. IS DECIDED BY INDIVIDUAL PATIENT FACTORS ▪ Factors which may weigh against the use of Other agents may be chosen for individual patients based calcium channel blockers include potential drug on concurrent medical conditions, patient tolerability and interactions, and diltiazem and verapamil are drug interactions. Indications for treatment with different contraindicated in heart block and heart failure. antihypertensive agents are discussed in BPJ 6 (June 2007). ▪ Choice between the different calcium channel blockers depends on patient tolerability, co- morbidity and drug interactions. FACTORS FOR AND AGAINST THE USE OF CALCIUM chANNEL BLOCKERS Factors that potentially favour the use of calcium channel Factors favouring use of calcium channel blockers include arrhythmia (verapamil only), angina, or high blockers: risk of stroke. Verapamil can also be used post myocardial infarction if beta blockers are contraindicated or not tolerated. ▪ Hypertension with co-morbid angina In addition, calcium channel blockers may be more suitable than other agents for elderly people and those of African ▪ Hypertension with co-morbid arrhythmia 1 (verapamil only) descent. -
Mobility Statistics and Automated Hazard Mapping for Debris Flows and Rock Avalanches
Mobility Statistics and Automated Hazard Mapping for Debris Flows and Rock Avalanches Scientific Investigations Report 2007–5276 Version 1.1 U.S. Department of the Interior U.S. Geological Survey Mobility Statistics and Automated Hazard Mapping for Debris Flows and Rock Avalanches By Julia P. Griswold and Richard M. Iverson Scientific Investigations Report 2007–5276 Version 1.1 U.S. Department of the Interior U.S. Geological Survey U.S. Department of the Interior DIRK KEMPTHORNE, Secretary U.S. Geological Survey Mark D. Myers, Director U.S. Geological Survey, Reston, Virginia: 2008 Revised 2014 This report and any updates to it are available at: http://pubs.usgs.gov/sir/2007/5276/ For product and ordering information: World Wide Web: http://www.usgs.gov/pubprod Telephone: 1-888-ASK-USGS For more information on the USGS--the Federal source for science about the Earth, its natural and living resources, natural hazards, and the environment: World Wide Web: http://www.usgs.gov Telephone: 1-888-ASK-USGS Any use of trade, product, or firm names is for descriptive purposes only and does not imply endorsement by the U.S. Government. Although this report is in the public domain, permission must be secured from the individual copyright owners to reproduce any copyrighted materials contained within this report. Suggested citation: Griswold, J.P., and Iverson, R.M., 2008, Mobility statistics and automated hazard mapping for debris flows and rock avalanches (ver. 1.1, April 2014): U.S. Geological Survey Scientific Investigations Report 2007-5276, 59 p. Manuscript approved for publication, December 12, 2007 Text edited by Tracey L. -
Alcoholism Pharmacotherapy
101 ALCOHOLISM PHARMACOTHERAPY JOSEPH R. VOLPICELLI SUCHITRA KRISHNAN-SARIN STEPHANIE S. O’MALLEY Alcoholism remains one of the most common and signifi- PHARMACOLOGIC TREATMENTS FOR cant medical problems in the United States and internation- ALCOHOL DETOXIFICATION ally. For example, in the United States, over 4% of the general population is alcohol dependent and another 5 to The first step in the pharmacologic treatment of alcoholism 10 million people drink hazardously at least several times is to help patients safely detoxify from alcohol. Although per month (1). The economic and medical costs of alcohol- historically, alcohol detoxification has occurred in inpatient ism and alcohol abuse continue to escalate. Most recent setting, increasingly alcohol detoxification is being con- figures put the economic costs of alcohol-related expenses ducted in ambulatory settings. Except in the case of medical at $176 billion annually in the United States (2). This in- or psychiatric emergencies, outcome studies generally show cludes the economic costs of increased health care expenses, that successful detoxification can safely and effectively be lost productivity at work, and legal expenses. Similarly, al- carried out in ambulatory setting using medications such though there have been some reductions in the number of as benzodiazepines (5,6). In addition, the use of anticonvul motor vehicle deaths attributed to excessive alcohol drink- sants has received recent interest. ing, the overall number of alcohol-related annual deaths is 105,000 in the United States (3). Benzodiazepines Current psychosocial approaches to alcohol addiction are moderately effective, with perhaps as many as half the pa- Benzodiazepines are �-aminobutyric acid (GABA) agonists tients receiving treatment becoming abstinent or signifi- that metaanalysis of placebo-controlled double-blind studies cantly reducing episodes of binge drinking (4). -
Antiparasitic Properties of Cardiovascular Agents Against Human Intravascular Parasite Schistosoma Mansoni
pharmaceuticals Article Antiparasitic Properties of Cardiovascular Agents against Human Intravascular Parasite Schistosoma mansoni Raquel Porto 1, Ana C. Mengarda 1, Rayssa A. Cajas 1, Maria C. Salvadori 2 , Fernanda S. Teixeira 2 , Daniel D. R. Arcanjo 3 , Abolghasem Siyadatpanah 4, Maria de Lourdes Pereira 5 , Polrat Wilairatana 6,* and Josué de Moraes 1,* 1 Research Center for Neglected Diseases, Guarulhos University, Praça Tereza Cristina 229, São Paulo 07023-070, SP, Brazil; [email protected] (R.P.); [email protected] (A.C.M.); [email protected] (R.A.C.) 2 Institute of Physics, University of São Paulo, São Paulo 05508-060, SP, Brazil; [email protected] (M.C.S.); [email protected] (F.S.T.) 3 Department of Biophysics and Physiology, Federal University of Piaui, Teresina 64049-550, PI, Brazil; [email protected] 4 Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand 9717853577, Iran; [email protected] 5 CICECO-Aveiro Institute of Materials & Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal; [email protected] 6 Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand * Correspondence: [email protected] (P.W.); [email protected] (J.d.M.) Citation: Porto, R.; Mengarda, A.C.; Abstract: The intravascular parasitic worm Schistosoma mansoni is a causative agent of schistosomiasis, Cajas, R.A.; Salvadori, M.C.; Teixeira, a disease of great global public health significance. Praziquantel is the only drug available to F.S.; Arcanjo, D.D.R.; Siyadatpanah, treat schistosomiasis and there is an urgent demand for new anthelmintic agents. -
Β-Adrenergic Modulation in Sepsis Etienne De Montmollin, Jerome Aboab, Arnaud Mansart and Djillali Annane
Available online http://ccforum.com/content/13/5/230 Review Bench-to-bedside review: β-Adrenergic modulation in sepsis Etienne de Montmollin, Jerome Aboab, Arnaud Mansart and Djillali Annane Service de Réanimation Polyvalente de l’hôpital Raymond Poincaré, 104 bd Raymond Poincaré, 92380 Garches, France Corresponding author: Professeur Djillali Annane, [email protected] Published: 23 October 2009 Critical Care 2009, 13:230 (doi:10.1186/cc8026) This article is online at http://ccforum.com/content/13/5/230 © 2009 BioMed Central Ltd Abstract in the intensive care setting [4] – addressing the issue of its Sepsis, despite recent therapeutic progress, still carries unaccep- consequences in sepsis. tably high mortality rates. The adrenergic system, a key modulator of organ function and cardiovascular homeostasis, could be an The present review summarizes current knowledge on the interesting new therapeutic target for septic shock. β-Adrenergic effects of β-adrenergic agonists and antagonists on immune, regulation of the immune function in sepsis is complex and is time cardiac, metabolic and hemostasis functions during sepsis. A dependent. However, β activation as well as β blockade seems 2 1 comprehensive understanding of this complex regulation to downregulate proinflammatory response by modulating the β system will enable the clinician to better apprehend the cytokine production profile. 1 blockade improves cardiovascular homeostasis in septic animals, by lowering myocardial oxygen impact of β-stimulants and β-blockers in septic patients. consumption without altering organ perfusion, and perhaps by restoring normal cardiovascular variability. β-Blockers could also β-Adrenergic receptor and signaling cascade be of interest in the systemic catabolic response to sepsis, as they The β-adrenergic receptor is a G-protein-coupled seven- oppose epinephrine which is known to promote hyperglycemia, transmembrane domain receptor. -
Family Group Sheets Surname Index
PASSAIC COUNTY HISTORICAL SOCIETY FAMILY GROUP SHEETS SURNAME INDEX This collection of 660 folders contains over 50,000 family group sheets of families that resided in Passaic and Bergen Counties. These sheets were prepared by volunteers using the Societies various collections of church, ceme tery and bible records as well as city directo ries, county history books, newspaper abstracts and the Mattie Bowman manuscript collection. Example of a typical Family Group Sheet from the collection. PASSAIC COUNTY HISTORICAL SOCIETY FAMILY GROUP SHEETS — SURNAME INDEX A Aldous Anderson Arndt Aartse Aldrich Anderton Arnot Abbott Alenson Andolina Aronsohn Abeel Alesbrook Andreasen Arquhart Abel Alesso Andrews Arrayo Aber Alexander Andriesse (see Anderson) Arrowsmith Abers Alexandra Andruss Arthur Abildgaard Alfano Angell Arthurs Abraham Alje (see Alyea) Anger Aruesman Abrams Aljea (see Alyea) Angland Asbell Abrash Alji (see Alyea) Angle Ash Ack Allabough Anglehart Ashbee Acker Allee Anglin Ashbey Ackerman Allen Angotti Ashe Ackerson Allenan Angus Ashfield Ackert Aller Annan Ashley Acton Allerman Anners Ashman Adair Allibone Anness Ashton Adams Alliegro Annin Ashworth Adamson Allington Anson Asper Adcroft Alliot Anthony Aspinwall Addy Allison Anton Astin Adelman Allman Antoniou Astley Adolf Allmen Apel Astwood Adrian Allyton Appel Atchison Aesben Almgren Apple Ateroft Agar Almond Applebee Atha Ager Alois Applegate Atherly Agnew Alpart Appleton Atherson Ahnert Alper Apsley Atherton Aiken Alsheimer Arbuthnot Atkins Aikman Alterman Archbold Atkinson Aimone -
Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive
brain sciences Review Attention-Deficit/Hyperactivity Disorder Predominantly Inattentive Subtype/Presentation: Research Progress and Translational Studies Ike C. de la Peña 1,* , Michael C. Pan 2,3, Chau Giang Thai 1 and Tamara Alisso 1 1 Department of Pharmaceutical and Administrative Sciences, Loma Linda University School of Pharmacy, Loma Linda, CA 92350, USA; [email protected] (C.G.T.); [email protected] (T.A.) 2 Department of Psychology, Korea University, Seoul 02841, Korea; [email protected] 3 Division of Social Sciences, University of the Philippines Visayas Tacloban College, Tacloban 6500, Philippines * Correspondence: [email protected]; Tel.: +1-909-651-5995; Fax: +1-909-558-0446 Received: 23 April 2020; Accepted: 9 May 2020; Published: 14 May 2020 Abstract: Research on the predominantly inattentive attention-deficit/hyperactivity disorder (ADHD-PI) subtype/presentation is important given its high prevalence, but paradoxically it is under-recognized and undertreated. The temporal stability of the inattention symptom could impact the high worldwide prevalence of ADHD-PI. Some evidence suggests differences in the nature of attentional deficit in ADHD-PI vs. that in other subtypes. Impairments in neuropsychological, neurocognitive, and social functioning are also evident in ADHD-PI, which could be specific to the subtype (e.g., processing speed, social perception, and skills), or differ from others in severity. Neuroimaging studies have also revealed ADHD-PI-specific neuropathological abnormalities and those that are shared with other subtypes. ADHD-PI is highly comorbid with learning and internalizing (e.g., anxiety and depression) disorders. There is no solid evidence for ADHD-PI-specific genetic etiologies and differential responses of subtypes to ADHD medications. -
Water on the Moon, III. Volatiles & Activity
Water on The Moon, III. Volatiles & Activity Arlin Crotts (Columbia University) For centuries some scientists have argued that there is activity on the Moon (or water, as recounted in Parts I & II), while others have thought the Moon is simply a dead, inactive world. [1] The question comes in several forms: is there a detectable atmosphere? Does the surface of the Moon change? What causes interior seismic activity? From a more modern viewpoint, we now know that as much carbon monoxide as water was excavated during the LCROSS impact, as detailed in Part I, and a comparable amount of other volatiles were found. At one time the Moon outgassed prodigious amounts of water and hydrogen in volcanic fire fountains, but released similar amounts of volatile sulfur (or SO2), and presumably large amounts of carbon dioxide or monoxide, if theory is to be believed. So water on the Moon is associated with other gases. Astronomers have agreed for centuries that there is no firm evidence for “weather” on the Moon visible from Earth, and little evidence of thick atmosphere. [2] How would one detect the Moon’s atmosphere from Earth? An obvious means is atmospheric refraction. As you watch the Sun set, its image is displaced by Earth’s atmospheric refraction at the horizon from the position it would have if there were no atmosphere, by roughly 0.6 degree (a bit more than the Sun’s angular diameter). On the Moon, any atmosphere would cause an analogous effect for a star passing behind the Moon during an occultation (multiplied by two since the light travels both into and out of the lunar atmosphere).