Mental Disorders
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Types of Bipolar Disorder Toms Are Evident
MOOD DISORDERS ASSOCIATION OF BRITISH COLUmbIA T Y P E S O F b i p o l a r d i s o r d e r Bipolar disorder is a class of mood disorders that is marked by dramatic changes in mood, energy and behaviour. The key characteristic is that people with bipolar disorder alternate be- tween episodes of mania (extreme elevated mood) and depression (extreme sadness). These episodes can last from hours to months. The mood distur- bances are severe enough to cause marked impairment in the person’s func- tioning. The experience of mania is not pleasant and can be very frightening to The Diagnotistic Statisti- the person. It can lead to impulsive behaviour that has serious consequences cal Manual (DSM- IV-TR) is a for the person and their family. A depressive episode makes it difficult or -im manual used by doctors to possible for a person to function in their daily life. determine the specific type of bipolar disorder. People with bipolar disorder vary in how often they experience an episode of either mania or depression. Mood changes with bipolar disorder typically occur gradually. For some individuals there may be periods of wellness between the different mood episodes. Some people may also experience multiple episodes within a 12 month period, a week, or even a single day (referred to as “rapid cycling”). The severity of the mood can also range from mild to severe. Establishing the particular type of bipolar disorder can greatly aid in determin- ing the best type of treatment to manage the symptoms. -
Pharmacogenomic Characterization in Bipolar Spectrum Disorders
pharmaceutics Review Pharmacogenomic Characterization in Bipolar Spectrum Disorders Stefano Fortinguerra 1,2 , Vincenzo Sorrenti 1,2,3 , Pietro Giusti 2, Morena Zusso 2 and Alessandro Buriani 1,2,* 1 Maria Paola Belloni Center for Personalized Medicine, Data Medica Group (Synlab Limited), 35131 Padova, Italy; [email protected] (S.F.); [email protected] (V.S.) 2 Department of Pharmaceutical & Pharmacological Sciences, University of Padova, 35131 Padova, Italy; [email protected] (P.G.); [email protected] (M.Z.) 3 Bendessere™ Study Center, Solgar Italia Multinutrient S.p.A., 35131 Padova, Italy * Correspondence: [email protected] Received: 25 November 2019; Accepted: 19 December 2019; Published: 21 December 2019 Abstract: The holistic approach of personalized medicine, merging clinical and molecular characteristics to tailor the diagnostic and therapeutic path to each individual, is steadily spreading in clinical practice. Psychiatric disorders represent one of the most difficult diagnostic challenges, given their frequent mixed nature and intrinsic variability, as in bipolar disorders and depression. Patients misdiagnosed as depressed are often initially prescribed serotonergic antidepressants, a treatment that can exacerbate a previously unrecognized bipolar condition. Thanks to the use of the patient’s genomic profile, it is possible to recognize such risk and at the same time characterize specific genetic assets specifically associated with bipolar spectrum disorder, as well as with the individual response to the various therapeutic options. This provides the basis for molecular diagnosis and the definition of pharmacogenomic profiles, thus guiding therapeutic choices and allowing a safer and more effective use of psychotropic drugs. Here, we report the pharmacogenomics state of the art in bipolar disorders and suggest an algorithm for therapeutic regimen choice. -
Neuropsychiatric Masquerades: Is It a Horse Or a Zebra NCPA Annual Conference Winston-Salem, NC October 3, 2015
Neuropsychiatric Masquerades: Is it a Horse or a Zebra NCPA Annual Conference Winston-Salem, NC October 3, 2015 Manish A. Fozdar, M.D. Triangle Forensic Neuropsychiatry, PLLC, Raleigh, NC www.BrainInjuryExpert.com Consulting Assistant Professor of Psychiatry, Duke University Medical Center, Durham, NC Adjunct Associate Professor of Psychiatry, Campbell University School of Osteopathic Medicine Disclosures • Neither I nor any member of my immediate family has a financial relationship or interest with any proprietary entity producing health care goods or services related to the content of this CME activity. • I am a non-conformist and a cynic of current medical establishment. • I am a polar opposite of being PC. No offense intended if one taken by you. Anatomy of the talk • Common types of diagnostic errors • Few case examples • Discussion of selected neuropsychiatric masquerades When you hear the hoof beats, think horses, not zebras • Most mental symptoms are caused by traditional psychiatric syndromes. • Majority of patients with medical and neurological problems will not develop psychiatric symptoms. Case • 20 y/o AA female with h/o Bipolar disorder and several psych hospitalizations. • Admitted a local psych hospital due to decompensation.. • While at psych hospital, she develops increasing confusion and ataxia. • Transferred to general med-surg hospital. • Stayed for 2 weeks. • Here is what happened…. • Psych C-L service consulted. We did the consult and followed her throughout the hospital stay. • Initial work up showed Normal MRI, but was of poor quality. EEG was normal. • She remained on the hospitalist service. 8 different hospitalists took care of her during her stay here. • Her presentation was chalked off to “her psych disorder”, “Neuroleptic Malignant syndrome” etc. -
Specificity of Psychosis, Mania and Major Depression in A
Molecular Psychiatry (2014) 19, 209–213 & 2014 Macmillan Publishers Limited All rights reserved 1359-4184/14 www.nature.com/mp ORIGINAL ARTICLE Specificity of psychosis, mania and major depression in a contemporary family study CL Vandeleur1, KR Merikangas2, M-PF Strippoli1, E Castelao1 and M Preisig1 There has been increasing attention to the subgroups of mood disorders and their boundaries with other mental disorders, particularly psychoses. The goals of the present paper were (1) to assess the familial aggregation and co-aggregation patterns of the full spectrum of mood disorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic criteria; and (2) to evaluate the familial specificity of the major subgroups of mood disorders, including psychotic, manic and major depressive episodes (MDEs). The sample included 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive disorder (MDD), 110 orthopedic controls, and 1734 adult first-degree relatives. The diagnostic assignment was based on all available information, including direct diagnostic interviews, family history reports and medical records. Our findings revealed specificity of the familial aggregation of psychosis (odds ratio (OR) ¼ 2.9, confidence interval (CI): 1.1–7.7), mania (OR ¼ 6.4, CI: 2.2–18.7) and MDEs (OR ¼ 2.0, CI: 1.5–2.7) but not hypomania (OR ¼ 1.3, CI: 0.5–3.6). There was no evidence for cross-transmission of mania and MDEs (OR ¼ .7, CI:.5–1.1), psychosis and mania (OR ¼ 1.0, CI:.4–2.7) or psychosis and MDEs (OR ¼ 1.0, CI:.7–1.4). -
Mental Health Disorders: Strategies for Approach & Treatment
3/20/2019 Mental Health Disorders: Strategies for Approach & Treatment Transform 2019: OPTA Annual Conference Columbus, Ohio April 6th, 2019 Dawn Bookshar, PT, DPT, GCS Ian Kilbride, PT Marcia Zeiger, OTRL Objectives Participants will: • Understand the prevalence and impact of mental health disorders in client populations • Understand clinical conditions, and associated characteristics of common mental health diagnoses • Apply effective treatment approaches for clients with mental illness. • Produce effective clinical documentation to support intervention for clients with mental illness Mental Illness (MI) www.schizophrenia.com 1 3/20/2019 Mental Illness (MI) The term mental illness refers collectively to all diagnosable mental disorders defined as sustained abnormal alterations in thinking, mood, or behavior associated with distress and impaired functioning which substantially interferes with or limits one or more major life activities. National Institute of Mental Health Prevalence of MI • More than 50% will be diagnosed with a mental illness or disorder at some point in their lifetime. • 1 in 5 Americans will experience a mental illness in a given year. • 1 in 25 Americans lives with a serious mental illness, such as schizophrenia, bipolar disorder, or major depression. Centers for Disease Control & Prevention Prevalence of MI in LTC • 2/3 of people in nursing homes have a mental illness. • Nursing home residents with a primary diagnosis of mental illness range from 18.7% among those aged 65-74 years to 23.5% among those aged 85+ years. • Dementia, Alzheimer disease, and mood disorders are the most common diagnoses of mental illness in long-term care settings. Centers for Disease Control & Prevention 2 3/20/2019 Prevalence of MI in LTC Ohio • Residents with a diagnosis of schizophrenia and bipolar disorder increased from 9% to 16% between 2001 to 2016. -
Understanding the Mental Status Examination with the Help of Videos
Understanding the Mental Status Examination with the help of videos Dr. Anvesh Roy Psychiatry Resident, University of Toronto Introduction • The mental status examination describes the sum total of the examiner’s observations and impressions of the psychiatric patient at the time of the interview. • Whereas the patient's history remains stable, the patient's mental status can change from day to day or hour to hour. • Even when a patient is mute, is incoherent, or refuses to answer questions, the clinician can obtain a wealth of information through careful observation. Outline for the Mental Status Examination • Appearance • Overt behavior • Attitude • Speech • Mood and affect • Thinking – a. Form – b. Content • Perceptions • Sensorium – a. Alertness – b. Orientation (person, place, time) – c. Concentration – d. Memory (immediate, recent, long term) – e. Calculations – f. Fund of knowledge – g. Abstract reasoning • Insight • Judgment Appearance • Examples of items in the appearance category include body type, posture, poise, clothes, grooming, hair, and nails. • Common terms used to describe appearance are healthy, sickly, ill at ease, looks older/younger than stated age, disheveled, childlike, and bizarre. • Signs of anxiety are noted: moist hands, perspiring forehead, tense posture and wide eyes. Appearance Example (from Psychosis video) • The pt. is a 23 y.o male who appears his age. There is poor grooming and personal hygiene evidenced by foul body odor and long unkempt hair. The pt. is wearing a worn T-Shirt with an odd symbol looking like a shield. This appears to be related to his delusions that he needs ‘antivirus’ protection from people who can access his mind. -
Which Is It: ADHD, Bipolar Disorder, Or PTSD?
HEALINGHEALINGA PUBLICATION OF THE HCH CLINICIANS’ HANDSHANDS NETWORK Vol. 10, No. 3 I August 2006 Which Is It: ADHD, Bipolar Disorder, or PTSD? Across the spectrum of mental health care, Anxiety Disorders, Attention Deficit Hyperactivity Disorders, and Mood Disorders often appear to overlap, as well as co-occur with substance abuse. Learning to differentiate between ADHD, bipolar disorder, and PTSD is crucial for HCH clinicians as they move toward integrated primary and behavioral health care models to serve homeless clients. The primary focus of this issue is differential diagnosis. Readers interested in more detailed clinical information about etiology, treatment, and other interventions are referred to a number of helpful resources listed on page 6. HOMELESS PEOPLE & BEHAVIORAL HEALTH Close to a symptoms exhibited by clients with ADHD, bipolar disorder, or quarter of the estimated 200,000 people who experience long-term, PTSD that make definitive diagnosis formidable. The second chronic homelessness each year in the U.S. suffer from serious mental causative issue is how clients’ illnesses affect their homelessness. illness and as many as 40 percent have substance use disorders, often Understanding that clinical and research scientists and social workers with other co-occurring health problems. Although the majority of continually try to tease out the impact of living circumstances and people experiencing homelessness are able to access resources comorbidities, we recognize the importance of causal issues but set through their extended family and community allowing them to them aside to concentrate primarily on how to achieve accurate rebound more quickly, those who are chronically homeless have few diagnoses in a challenging care environment. -
Anxiety Disorders
TECHNICAL COMMENTARY Anxiety disorders Introduction excluded from the library. The PRISMA flow diagram is a suggested way of providing Anxiety disorders are a group of mental information about studies included and disorders characterised by excessive fear or excluded with reasons for exclusion. Where no worrying. It is important to recognise comorbid flow diagram has been presented by individual anxiety as it may influence treatment strategies reviews, but identified studies have been and outcomes. described in the text, reviews have been Anxiety disorders include generalised anxiety checked for this item. Note that early reviews disorder, which is characterised by continuous may have been guided by less stringent and excessive worrying for six months or more. reporting checklists than the PRISMA, and that Specific phobias are characterised by anxiety some reviews may have been limited by journal provoked by a feared object/situation, resulting guidelines. in avoidance. Social phobia is anxiety provoked Evidence was graded using the Grading of by social or performance situations. Recommendations Assessment, Development Agoraphobia is anxiety about situations where and Evaluation (GRADE) Working Group escape may be difficult or help might not be approach where high quality evidence such as available. Panic disorder is characterised by a that gained from randomised controlled trials panic attack, which is a distinct episode where (RCTs) may be downgraded to moderate or low a person experiences sudden apprehension if review and study quality is limited, if there is and fearfulness, where they may present with inconsistency in results, indirect comparisons, shortness of breath, palpitations, chest pain or imprecise or sparse data and high probability of choking. -
Ulsd730704 Td Luis Madeira.Pdf
UNIVERSIDADE DE LISBOA FACULDADE DE MEDICINA BASIC-SELF DISORDERS BEYOND SCHIZOPHRENIA: ULTRA-HIGH-RISK STATES AND PANIC DISORDER Luis António Proença Duarte Madeira Orientadores: Prof. Doutora Maria Luísa Caruana Canessa Figueira da Cruz Filipe Prof. Doutor Louis Arnorsson Sass Tese especialmente elaborada para obtenção do grau de Doutor em Medicina Especialidade em Psiquiatria e Saúde Mental 2017 A impressão desta dissertação foi aprovada pelo Conselho Científico da Faculdade de Medicina da Universidade de Lisboa em reunião de 23/11/2016 UNIVERSIDADE DE LISBOA FACULDADE DE MEDICINA BASIC-SELF DISORDERS BEYOND SCHIZOPHRENIA: ULTRA-HIGH-RISK STATES AND PANIC DISORDER Luis António Proença Duarte Madeira Orientadores: Prof. Doutora Maria Luísa Caruana Canessa Figueira da Cruz Filipe Prof. Doutor Louis Arnorsson Sass Tese especialmente elaborada para obtenção do grau de Doutor em Medicina Especialidade em Psiquiatria e Saúde Mental Juri: Presidente: Prof. Doutor José Luis Bliebernicht Ducla Soares, Prof. Catedrático em regime de tenure e Vice-Presidente do Conselho Científico da Faculdade de Medicina da Universidade de Lisboa Vogais: Prof. Doutor Carlos Manuel Moreira Mota Cardoso, Professor Catedrático da Faculdade de Psicologia e Ciências da Educação da Universidade do Porto Prof. Doutor João Eduardo Marques Teixeira, Professor Associado da Faculdade de Psicologia e Ciências da Educação da Universidade do Porto Prof. Doutor Manuel Gonçalves Pereira, Professor Auxiliar da Faculdade de Ciências Médicas da Universidade Nova de Lisboa Prof. Doutor Daniel José Branco de Sampaio, Professor Catedrático Jubilado da Faculdade de Medicina da Universidade de Lisboa Prof. Doutora Maria Luísa Caruana Canessa Figueira da Cruz Filipe, Professora Catedrática Jubilada da Faculdade de Medicina da Universidade de Lisboa (orientador) Prof. -
Differentiating Schizoaffective and Bipolar Disorder: a Dimensional Approach
ECNP Berlin 2014 Differentiating schizoaffective and bipolar disorder: a dimensional approach Heinz Grunze Newcastle University, Institute of Neuroscience, Academic Psychiatry, Newcastle upon Tyne, UK http://www.ncl.ac.uk/ion/staff/profile/heinz.grunze http://www.ntw.nhs.uk/sd.php?l=2&d=9&sm=15&id=237 Disclosures o I have received grants/research support, consulting fees and honoraria within the last three years from BMS, Desitin, Eli Lilly, Gedeon Richter, Hoffmann-La Roche,Lundbeck, Otsuka, and Servier o Research grants: NHS National Institute for Health Research/Medical Research Council UK o Neither I nor any member of my family have shares in any pharmaceutical company or could benefit financially from increases or decreases in the sales of any psychotropic medication. During this presentation, some medication may be mentioned which are off-label and not or not yet licensed for the specified indication!! The content of the talk represents solely the opinion of the speaker, not of the sponsor. SCZ and BD means impairment at multiple levels- and we assume SAD, too Machado-Vieira et al, 2013 The polymorphic course of Schizoaffective Disorder Schizophrenic Depressive Manic syndrome syndrome syndrome Marneros et al. 1995. Dimensional view of Schizoaffective Disorder (SAD) vs Bipolar Disorder (BD) Genes Brain morphology and Function Symptomatology Outcome Dimension SAD AND GENES Bipolar and schizophrenia are not so different….. 100% Non-shared environmental 90% effects 80% 70% Shared environmental 60% effects 50% 40% 30% Unique genetic effects 20% 10% 0% Shared genetic effects Schizophrenia Bipolar Disorder Variance accounted for by genetic, shared environmental, and non-shared environmental effects for schizophrenia and bipolar disorder. -
Did the Author of Psalm 30 Have Cyclothymia Or Bipolar Disorder
Kisely et al 25 Antiplatelet Trialists’ Collaboration. Collaborative overview of randomised 35 Lawrence D, Jablensky AV, Holman CD, Threlfall TJ, Fuller SA. Excess cancer trials of antiplatelet therapy. Prevention of death, myocardial infarction, and mortality in Western Australian psychiatric patients due to higher case stroke by prolonged antiplatelet therapy in various categories of patients. fatality rates. Acta Psychiatrica Scand 2000; 101: 382–8. BMJ 1994; 308: 81–106. 36 Kisely S, Sadek J, MacKenzie A, Lawrence D, Campbell LA. Excess cancer 26 Lip GY, Edwards SJ. Stroke prevention with aspirin, warfarin and mortality in psychiatric patients. Can J Psychiatry 2008; 53: 753–61 ximelagatran in patients with non-valvular atrial fibrillation: a systematic 37 Rieckmann N, Kronish IM, Haas D, Gerin W, Chaplin WF, Burg MM, et al. review and meta-analysis. Thromb Res 2006; 118: 321–33. Persistent depressive symptoms lower aspirin adherence after acute 27 Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use coronary syndromes. Am Heart J 2006; 152: 922–7. with ICD-9-CM administrative databases. J Clin Epidemiol 1992; 45: 613–9 38 Shander D. Cardiovascular procedures in patients with mental disorders. 28 Bradford DW, Kim MM, Braxton LE, Marx CE, Butterfield M, Elbogen EB. JAMA 2000; 283: 3198–9. Access to medical care among persons with psychotic and major affective 39 Daumit GL, Pronovost PJ, Anthony CB, Guallar E, Steinwachs DM, Ford DE. disorders. Psychiatr Serv 2008; 59: 847–52. Adverse events during medical and surgical hospitalizations for persons with 29 Kilbourne AM, Welsh D, McCarthy JF, Post EP, Blow FC. -
The ICD-10 Classification of Mental and Behavioural Disorders Diagnostic Criteria for Research
The ICD-10 Classification of Mental and Behavioural Disorders Diagnostic criteria for research World Health Organization Geneva The World Health Organization is a specialized agency of the United Nations with primary responsibility for international health matters and public health. Through this organization, which was created in 1948, the health professions of some 180 countries exchange their knowledge and experience with the aim of making possible the attainment by all citizens of the world by the year 2000 of a level of health that will permit them to lead a socially and economically productive life. By means of direct technical cooperation with its Member States, and by stimulating such cooperation among them, WHO promotes the development of comprehensive health services, the prevention and control of diseases, the improvement of environmental conditions, the development of human resources for health, the coordination and development of biomedical and health services research, and the planning and implementation of health programmes. These broad fields of endeavour encompass a wide variety of activities, such as developing systems of primary health care that reach the whole population of Member countries; promoting the health of mothers and children; combating malnutrition; controlling malaria and other communicable diseases including tuberculosis and leprosy; coordinating the global strategy for the prevention and control of AIDS; having achieved the eradication of smallpox, promoting mass immunization against a number of other