OVERVIEW OBJECTIVES ORGANIZATION OF EVALUATION CRITERIA VISION FOR 2018-2022 THE CINTESIS UNIT PARTICIPATING ACCOMPLISHMENTS FOR 2018-2022 INSTITUTIONS

APPLICATION SUMMARY

Center for Health Technology and Services Research

cintesis.eu OVERVIEW & VISION 2018-2022 title cintesis: Overview and Vision 2018-2022 editors Altamiro Costa Pereira António Soares co-editors Cláudia Azevedo Olga Estrela Magalhães Milaydis Sosa Napolskij graphic design Bárbara Mota Pedro Sacadura photography Alfredo Mendes de Castro/cintesis Bárbara Mota/cintesis Cláudia Azevedo/cintesis Egídio Santos/uporto Miguel Nunes/fmup Olga Estrela Magalhães/cintesis Pedro Granadeiro/cintesis ipo/cintesis uaveiro/cintesis 2 Overview 4 Vision 5 Objectives 9 Main Accomplishments 10 Organization 32 Evaluation Criteria 37 Institutions 40 Abbreviations & Acronyms 42 Researchers cintesis: overview & vision 2018-2022 2 overview

Overview

cintesis is a health research unit comprising 485 of inclusiveness and scientific capacitation. In researchers from 46 institutions from all Portuguese particular, cintesis aims to foster strong research regions (including Madeira and Azores) that teams in often neglected professional areas, collaborates with international researchers from over geographical regions, and scientific fields (e.g., Clinical 50 institutions around Europe, North America and Research, Public Health, Primary Care, and Nursing). Portuguese-speaking countries. This unit consists of Thus,cintesis is focused on creating opportunities a multidisciplinary health research cluster working for less appealing regions to be able to attract qualified to promote high-quality and high-impact scientific health researchers, thus leading to a better distribution outputs while addressing relevant societal issues and of human and capital resources within our National increasing technology transfer to the health industry. Scientific and Health Systems.

Unlike traditional research units, cintesis has a cintesis works closely with 4 main stakeholders, highly decentralized structure, in tandem with its namely the academic community, healthcare providers, national coverage. Moreover, cintesis researchers health industry, and patients and other members of are well integrated within 29 education institutions the general public. With this, we aim to (i) increase – including Universities and Polytechnic Institutes –, health prevention knowledge, (ii) develop and 12 healthcare providers, and 5 health smes. evaluate safer and more efficient health interventions, and (iii) increase the wider and better use of evidence Another principle that differentiatescintesis from and information technologies by healthy individuals, traditional research units lies in its founding precept patients and health professionals. cintesis: overview & vision 2018-2022 overview 3

ABOVE: MEDICAL RESEARCH CENTER FACULTY OF MEDICINE OF THE UNIVERSITY OF PORTO

ON THE RIGHT: ALTAMIRO DA COSTA PEREIRA SCIENTIFIC COORDINATOR cintesis: overview & vision 2018-2022 4 vision

Vision

In accordance with its These goals are not to have a positive impact CINTESIS MEETING, 2017 founding principles and limited to the production on society as a whole and research thematic lines of research outputs, to contribute to strengthen (tl), cintesis aims to despite their importance. the National Scientific consolidate its role as an Other elements are also System, to contribute international reference in involved such as students to the sustainability and Gastrointestinal Oncology, and researchers in safety of the National Inflammatory Bowel advanced education and Health System, and to Disease and Asthma, training, the provision of decrease health inequities. as well as to become an knowledge transfer and international reference in partnerships with industry, several other fields such and the engagement with as Health Data Science patients and other mem- and Digital Health. At a bers of the general public. national level, cintesis is set to maintain its With this vision, leading role in such fields cintesis aims to produce as Nursing, Primary Care high-quality and and Evidence-Based innovative research. In Medicine. addition, cintesis aims cintesis: overview & vision 2018-2022 objectives for 2018-2022 5

Objectives for 2018-2022

Research A Activities

The3 tls of cintesis (i.e. tl1 Preventive Health and and (iii) working towards its inclusion in eu-funded Societal Challenges, tl2 Clinical and Translational projects, particularly in the fields of Critical Care, Research, and tl3 Health Data and Decision Sciences Oncology, Cardiovascular and Ageing. & Information Technologies) are structured according to national and international health Additionally, cintesis is set to consolidate its role in research priorities, agendas and the 2030 Horizon. In being a national reference in several areas, including fact, the tl3 deals with the 4th and the 5th research some often neglected (but with large societal impact) subthemes of fct’s National Agenda for Health, research fields, such as Nursing, Primary Care, Clinical and Translational Research (Digital Health Geriatric Mental Health, Health Technology and Health Technology Assessment, respectively), Assessment, and Health Services Research. while the tl1 and the tl2 relate with the 1st and the Collaboration and communication with national 3rd subthemes (Active Ageing and Advanced health authorities will also be sought so that knowledge Therapies, respectively). can be successfully applied.

These alignments provide opportunities not only for These research activities will be supported by cintesis obtaining funding, but also for cintesis to expand its science managers, particularly in what concerns international prominence, particularly by (i) becoming with funding applications, diversification of national an international reference in fields like Health Data and international funding sources with involvement Science and Digital Health, (ii) fostering large of relevant entities such as the eu, the fct and the multinational and multicentric observational studies; Fundação La Caixa, networking with national and cintesis: overview & vision 2018-2022 6 objectives for 2018-2022

international research leaders, and provision of support in manuscript writing and statistical analysis. Particular care will be taken so that these services B will be provided to researchers from institutions or scientific fields with less developed research infra-structures.

In order to monitor the accomplishment of these goals, and in tandem with the aims of the Charter group of the tl1, we will develop benchmarks aiming Advanced Education to assess research impact, including (i) fct and Training investment per obtained citation, (ii) investment per research discussed in the mass media, (iii) proportion of publications with young researchers as first author, and (iv) number of prizes per projects developed. cintesis aims to consolidate its role as a leading provider of advanced education programs in emerging areas of knowledge (with particular emphasis on the core phd programs more directly related to cintesis members), mostly by (i) fostering a higher impact of research developed under the aegis of these programs, and (ii) by increasing the proportion of international students. This will contribute to im- prove the skills and knowledge of cintesis members, as well as to cement its role as leader in several areas of knowledge.

In order to accomplish these aims, the course of action of cintesis will rely on:

CENTRE OF BIOMEDICAL 1 Supporting the 2 Promotion and 3 Assure regional and SIMULATION, FACULTY OF MEDICINE OF THE training of young organization of professional equity UNIVERSITY OF PORTO researchers through educational activities in their access to advanced education to improve skills and the aforementioned programs (phd, msc and knowledge on practical educational activities Continuing Education) matters, such as funding under the responsibility applications, research of cintesis researchers methods and scientific publishing cintesis: overview & vision 2018-2022 objectives for 2018-2022 7

C

Dissemination of Scientific Knowledge and Social Impact

Knowledge needs to be applied in order to serve society. cintesis aims to assure that its scientific activity has a positive impact on the society as a whole. This is to be accomplished by:

1 Development of performed both via society-centered research traditional and more activities. cintesis aims innovative media, targeting to consolidate its leading different subgroups, from role in developing common laymen to decision technologies to be makers and keystake- used by everyone (such holders in public policy as healthcare apps) and design. A good scientific in researching implemen- communication is tation of scientific expected to have a knowledge in society positive impact in (i) promoting scientific 3 Provision of external ABOVE: HEALTH RESEARCH 2 Development of literacy, (ii) promoting consultancy services outreach activities aiming the adoption of evidence- in research methods, BELLOW: DATA PROCESSING to raise awareness and -based decisions by policy biostatistics, information educate the general public stakeholders, and (iii) systems, and development regarding the main subject raising awareness for and management of areas of each tl. This the importance of research and information communication will be funding research infrastructures cintesis: overview & vision 2018-2022 8 objectives for 2018-2022

D E

Knowledge Transfer Infrastructures

cintesis aims to be a relevant partner in national cintesis aims to strengthen its research support and international consortia with healthcare industry infrastructures (e.g. information systems, databases and smes. This will be accomplished by (i) acting and communication platforms), so that its research as an important service provider for the community, activity becomes more efficient.cintesis will also healthcare institutions and industry/smes (e.g. try to secure specifically allocated premises in the food industry); and (ii) promoting knowledge University of Porto, with at least 500 m2 and mainly transfer and collaboration with health authorities composed of office and dry lab spaces (ideal premises and policy makers. would be the old fmup/ibcas building). These premises would be used by cintesis management The development of clinical, commercial and industrial team, spin-offs and inter-institutional research groups applications of the knowledge and technologies (e.g. Polytechnic Institutes and Universities). produced is thus one of the main strategic goals of cintesis. This path will be pursued in accordance with cintesis tl, which are to guide the implemen- tation of such solutions and set the specific develop- ment areas to be addressed. Accordingly, cintesis aims to create, within the next 5 years, at least 2 new spin-offs and2 new patents. cintesis: overview & vision 2018-2022 objectives for 2018-2022 9

Main Accomplishments cintesis: overview & vision 2018-2022 10 cintesis organization 2018-2022

CINTESIS organization 2018-2022

Organizational Concept ABOVE: CINTESIS’ LIBRARY

BELLOW: CINTESIS MEETING, 2017 cintesis: overview & vision 2018-2022 cintesis organization 2018-2022 11

The proposed network-like structure, organization While keeping activities monitored cintesis promote and governance model for cintesis aims to provide rg’s autonomy as well as individual self-accountability. a highly performing and efficient environment for Health Sciences and Health Care Research. Routine management activities are carried by an The unit relies on a highly flexible and decentralised operational management team (mt) supervised by the management structure, described below, supported by uc and the ssc. Themt comprises a variety of expertise administrative and technical staff from 46 institutions to support the full cycle of research and innovation: protocolled with the Unit, including 8 local management call participation (e.g. consortium building); project hubs at 5 universities (uporto, uaveiro, nova, ualgarve, management (e.g. financial and human/material umadeira) and 1 polytechnic (Nursing School of Porto - esep). resources management); research dissemination (e.g. publishing, media communication); and knowledge While most cintesis researchers are fully funded by transfer activities. their own institutions, they can use lab resources, equipment and office spaces from all these46 affiliated While the uc is elected by the Scientific Council of entities, which greatly minimizes the need to build cintesis, which comprises all integrated members and/or maintain large specific Unit facilities. of the Unit, the pis are elected only by the integrated members of each rg, and each Thematic Line Coordinator A flagship of this symbiotic and efficient use of existing is elected by the pis of the respective rg. resources is the Faculty of Medicine, University of Porto (fmup), which provides nearly 5.000 m2 of lab and In addition, a joint committee – which comprises office space, besides a significant amount of equipment representatives of all of the 8 Management Institutions and more than 100 faculty staff and technicians. (hubs) of cintesis (i.e. fmup, icbas, fcup, uaveiro, nova, Altogether, it is estimated that cintesis researchers ualgarve, umadeira and esep) - deals with issues can use nearly 20.000 m2 of laboratory, library and office related to projects and matters at an institutional level. space, besides a significant amount of equipment, involving a total of more than 300 staff and technicians The proposed governance and scientific management not directly paid by the Unit. model is likely to reinforce significantly the Portuguese scientific and technological system as it involves nearly 500 researchers (198 doctorate integrated members) Governance & Scientific Management covering the main Portuguese regions (e.g. North, Although strategic research activities are promoted Center, Lisbon, Algarve, Madeira and Azores). In this by a Scientific Steering Committee ssc( ) - comprising context, cintesis is likely to have a significant regional the Principal Investigators (pis) of the Research and national impact and also address, in a cost-effective Groups (rg), the Coordinators of the Thematic Lines manner, the highly complex research and current societal (tl) and the Unit’s Coordinator (uc) – integrated challenges, namely concentrating on important areas researchers (individually or through their group pi) that are often neglected in terms of research funding can provide their own scientific and management (e.g. Nursing, Primary Care or Preventive Research). inputs regarding the way the Unit activities are planned and implemented. Although there is a number of Therefore,cintesis will provide an efficient and highly agreed rules and procedures, the decision-making adaptable research unit, capable of scaling up and process is mostly delegated to the rg level, aiming leveraging expertise and research experience across to increase the active participation of all researchers. all regions of Portugal. cintesis: overview & vision 2018-2022 12 cintesis organization 2018-2022

CINTESIS’ SCIENTIFIC STRUCTURE 2018-2022

Scientific Structure The3 thematic lines (tl) for cintesis i.e. Preventive to support diagnosis and treatment of important diseases; Medicine & Societal Challenges (tl1), Clinical & and the 9 rg in tl3 focus on the development of Translational Research (tl2) and Health Data and methodologies, tools and technologies regarding data Decision Sciences & Information Technologies collection and analysis, decision making and evaluation (tl3) are strongly aligned with the major priorities of health interventions. defined by h2020 (and what is known of fp9 and pt2030) for Health Research in Europe and the The threetl have also been designed to maximize fct National Agenda for Health, Clinical and research interactions and complementarities of expertise Translational Research. among the proposed rg. In total, the 23 rg provide the needed research capacities and expertise to perform Thesetl comprise 23 research groups (rg) that address translational research and innovation within real healthcare key Health and Societal Challenges. The6 rg in tl1 environment. In Portugal, very few, if any, research focus on preventive research to relevant societal units have such wide health research scope, combining challenges; the 8 rg in tl2 address clinical and translational public health issues and methods with information research aiming to deliver new knowledge and products technologies and clinical and translational research. cintesis: overview & vision 2018-2022 research groups 13

TL1: Preventive Medicine & Societal Challenges

CONCEIÇÃO CALHAU BELLOW: PRINCIPAL INVESTIGATOR PROMOTION AND SYNTHESIS OF SCIENTIFIC EVIDENCE

AgeingC – AgeingCluster

AgeingC is a multidisciplinary group of cintesis constituted by sixty researchers who focus their study on two areas: a) Social & Behavioural Gerontology (i.e. ageing process, policy and services), and b) Clinical Gerontology & Geriatrics (for example, fragility, mental health and dementia, family care, use of new technology for an independent life and the well-being CINTESIS’ SCIENTIFIC STRUCTURE 2018-2022 of the elderly). The objective is to develop and implement actions that increase the individuals’ empowerment, closely engaging health and education institutions and Main achievements: In the last 5 years, AgeingC establishing the necessary link with the community’s members have been researching in mental health existing resources. Likewise, the group seeks to develop dementia caregiving and aal. Some of these projects and implement new care models (integrated care include Care Needs of People with Dementia; toy leading to efficiency gains) and novel approaches for - Together Old and Young; Sounds4Health; Cuidem - the elderly, in accordance with current knowledge on Cuidados para a Demência; mentha - Mental Health the ageing process and the best practices in Gerontology and Aging and Active Advice project. This group focus and Geriatrics. on research on the oldest-old, providing a unique contribution to the study of centenarians by conducting the only existing project on the subject in Portugal. This project integrates the most important international group dealing with Centenarians (International Centenarian Consortium). AgeingC team also develops ÓSCAR RIBEIRO PRINCIPAL INVESTIGATOR a pioneer work in training within the ageing field, implementing numerous workshops and training sessions via ongoing research projects. cintesis: overview & vision 2018-2022 14 research groups

Charter – Challenges and Strategies in Health Research

Created to develop projects that address the complexity of scientific, technological and ethical challenges resulting from investigation in the health field, the Main achievements: Charter is a new research group. Charter – Challenges and Strategies in Health Research, Nevertheless, within the past years, Charter members is a new group of cintesis that integrates 18 researchers. had individually developed several societal and scientific The main objectives of this group are to promote contributions. Their members had provided a continuous collaborative interdisciplinary investigation among direct involvement within a wide spectrum of health researchers from different backgrounds and contribute research (Data Science, Signal Processing, Health to widen the scientific debate within the scientific Policy and Ethics, Active Ageing, and Neurogenesis community and society as a whole. For that, the focus Translational Research). Charter researches were is placed on the main challenges that arise from the deeply involved in student training, including in laboratory bench to the patient’s bedside, as well as teaching and coordinating Master Degree and phd from health services, especially what concerns to programs. Charter researchers also played an resources allocation, education, professional development, important role in university, health services, and and ethical dilemmas. professional institutions and agencies decisions.

ABOVE: COLLABORATIVE JOÃO BERNARDES INVESTIGATION PRINCIPAL INVESTIGATOR

ManEthics – Healthcare Management & Ethics

The ManEthics research group atcintesis aims to Main achievements: ManEthics group have been research and develop education and international enrolled in different International projects namely cooperation. With a special focus on scientific research with the objective of strengthening the international and on quality education, ManEthics has attracted cooperation between different centres at a global level. national and foreign researchers with different This strategic goal has been achieved through integra- professional backgrounds. In the framework of its tion in the unesco Chair in Bioethics, in particular. strategy of gradual internationalization, the group has Researchers of the ManEthics group are also responsible established cooperation protocols and partnership for two doctoral programmes, concerning societal key agreements with a number of renowned institutions all issues (Bioethics and Palliative Care). Additionally, over the world, allowing them to assume an increasingly ManEthics group members have engaged in several significant role in the international scientific production. activities with the society, by participating in debates over ethical issues (including in discussions organized by the mass media) and by counseling of decision- -makers and politicians. GUILHERMINA RÊGO PRINCIPAL INVESTIGATOR cintesis: overview & vision 2018-2022 research groups 15

NursID – Innovation & Development in Nursing

Nursid is a research group focused on the needs of Main achievements: Nursid members published over individuals, families and the community in terms of 350 papers in research journals between 2015 and Nursing, aiming to contribute to a multidisciplinary 2017, focusing on different issues related to nursing and holistic approach to health. Currently, Nursid is practice, education and societal impact. During that constituted by near 130 researchers, including period, Nursid developed 14 projects, some of them integrated members, students and other collaborators. with strong societal impact. Intent-Care links nursing Most of them come from the Nursing School of Porto knowledge to informal caregivers of dependent people (esep), as a result of a strategic collaboration with and is based on the construction of an interactive cintesis aiming to reinforce research in Nursing. educational technology tool that provides information tailored to the needs of family caregivers of dependent people in self-care. Nucre-3ds project, a nursing clinical reasoning education project, aims to develop decision- CARLOS SEQUEIRA -making skills based on a problem-based learning tool. PRINCIPAL INVESTIGATOR At last, SafeCare project is a clinical supervision project for safety and quality of care that allowed to define a model for deepening knowledge and developing of skills in nursing. This project aims to promote the ABOVE: COLLABORATIVE quality and safety of nursing care provided to National INVESTIGATION Health System patients, assessing, for the first time ever, the relevance of clinical supervision for the quality of care provided in hospital settings. PrimeCare – Primary Health Care Research

The research group PrimeCare is constituted by researchers strongly involved in care provision to patients Main achievements: PrimeCare is a new research who are at different levels within the Portuguese group. Nevertheless, within the past years, PrimeCare healthcare system. This allows them to benefit from a members had individually developed several societal network of partnerships with many healthcare entities, and scientific contributions in the field of Primary Care, and to constantly encounter real-world problems that such as the characterization of clinical tests demands can be solved through research. Centred in five levels by doctors; promotion of health literacy and patient of prevention – primary, secondary, tertiary, quaternary enablement in chronic diseases. PrimeCare researchers and primordial prevention, PrimeCare aims to contribute developed Metis, an Internet encyclopaedia-style resource to the strengthening of Primary Care by implementing aiming to explain clinical conditions, diagnostic tests and a structured, rigorous and methodologically strong research. treatments in simple language accessible to everyone.

PrimeCare also showed that worse health literacy associates with poorer disease outcomes in Portuguese patients PAULO SANTOS with diabetes mellitus type 2 and assessed the best PRINCIPAL INVESTIGATOR strategies to follow, identifying the importance of delivering leaflet written information to improve medication adherence. cintesis: overview & vision 2018-2022 16 research groups

ProNutri – Clinical Nutrition & Disease Programming .

ProNutri is a multidisciplinary research group constituted by integrated researchers and collaborators of cintesis coming from different national institutions, namely from the nova Medical School – Faculty of Medical Main achievements: In the past years, ProNutri Sciences of Lisbon, the Faculty of Nutrition and Food identified the beneficial and harmful factors from diet, Science and the Faculty of Medicine of the University including bioactive compounds and endocrine of Porto, besides several public and private hospitals disrupting chemicals (edcs). ProNutri data showed of reference. The objective of ProNutri is to identify the that paediatric exposure to edc - bpa - is higher than causal effects and progression mechanisms of chronic in adults. This biomonitoring data may help formulating diseases for which food plays an important role, chemical policies by providing novel scientific evidence namely, Diabetes type 2, cardiovascular diseases, of pervasive exposures. This research group also neurodegenerative diseases and cancer; thereby demonstrated that peri-gestational exposure to high contributing to the development of prevention folic acid induces metabolic dysfunction in the strategies and new therapeutic targets. offspring. Additionally, the IoGeneration study, funded by eea-Grants, concluding that 32% of children had iodine deficiency while no school canteen had implemented the iodized salt policy. This prompted the drafting of an Inter-Institutional Agreement on ELISA KEATING iodized salt and other policy actions. This team is PRINCIPAL INVESTIGATOR involved in a case report in São Tomé e Príncipe in the maternal and child healthcare areas studying, since 2009, a representative sample of 1285 children from 7 districts. ProNutri is also contributing to the promotion of international consensus treatment guidelines and performed a new and successful dietary management of maternal pku with glycomacropeptide and amino acids supplements.

BLOOD SAMPLING ESEP - NURSING SCHOOL OF PORTO cintesis: overview & vision 2018-2022 research groups 17

TL2: Clinical & Translational Research

MÁRIO DINIS RIBEIRO PRINCIPAL INVESTIGATOR

BioOncoSim – Biomolecular Oncology Therapy

BioOncoSim – Biomolecular Medicine & Computational Simulation is a research group committed to the development of clinical and epidemiological research in the area of Biomolecular Medicine, and of computational simulation models in the field of oncology therapy. In the field of oncology therapy, there is a growing Main achievements: This group has been delivering demand for bioinformatics models to develop safer several outputs putting together diverse competences pharmacological interventions. Molecular Medicine in molecular epidemiology and computational simulation integrates the contributions of several scientific areas in collaboration with international institutions, such with the latest medical advancements to describe as the Research Group Genomic Epidemiology in molecular structures and mechanisms, identify key Heidelberg, the Laboratory of Immunogenetics at the molecular and genetic errors of a disease and develop Brigham Hospital in Boston and the Hospital John corrective molecular interventions. In that context, Radcliffe. Members of this research group are principal this group aims to test the effectiveness, precision, investigators (pi) of 3 projects, 1 focused on the chemistry safety and cost-benefit of innovative oncological of the plp enzymes, and 2 focused on the development treatment, through de development of simulation of computational drug design methods. They were also models, in silico trials and epidemiological and pis of 4 Clinical trials on Multiple Myeloma, Lymphomas prospective multicentre projects with patients. and Myelodisplastic Syndrome in Academic Clinical Center of Braga Hospital, including the new monoclonal antibody to immune check point inhibitors. BioOncoSim researchers were awarded with 2 fct grants for career projects focused on the computational studies addressed HERLANDER MARQUES to enzymatic catalysis and on the development and PRINCIPAL INVESTIGATOR application of computational tools for drug design and discovery, in the interface between theory and experiment. cintesis: overview & vision 2018-2022 18 research groups

CardioCare – Cardiovascular Sciences

The CardioCare research group aims to contribute to Main achievements: CardioCare participates in the the continuous progress of knowledge and practice in Portuguese Coordination and in the National the field of Clinical Cardiology, focusing on the Coordinators Committee of paradigm-hf, a landmark prevention, diagnosis, and approach to cardiovascular study that instituted a new strategy for the treatment diseases. The main research areas of the CardioCare of Heart Failure with reduced ejection fraction that group include prevention, epidemiology, genetics, reduces significantly mortality as compared with imaging, pharmacological therapy, health devices, and standard therapy. This research group developed the health policies regarding cardiovascular diseases in SmartBeat project to produce and commercialize a general and some diseases and conditions in particular, device for heart failure telemonitoring aimed at reducing namely, arrhythmias, cardiomyopathies, heart failure heart failure hospitalizations. This line of investigation or cardiac involvement in aids. was awarded with a 3.2 million euros grant by the aal 2014 call. Lately, CardioCare members are working on DeusExMachina project to improve SmartBeat telemonitoring device by solving the issue of technology JOSÉ SILVA CARDOSO PRINCIPAL INVESTIGATOR adherence, a major problem amongst Heart Failure population. This line of investigation was awarded with a 2.6 million euros grant by the n2020 2015 Call.

CriticalMed – Critical Care & Emergency Medicine

The research group CriticalMed aims at promoting innovative interdisciplinary research and at increasing knowledge in this area, to ensure improvement of prevention, diagnosis, approach, and treatment of critically ill patients. The group benefits from the vast experience of its members (integrated researchers and Main achievements: In the last years, CriticalMed collaborators). In Portugal and abroad, it occupies team is engaged with ethical issues and end of life a relevant position as an important partner in the decisions in critically ill patients. This research group research of pressing topics of Emergency Medicine have developed new fields of research on cost/ and of Critical Care. Some of this topics are patients’ satisfaction studies for ophthalmic surgery; cognitive quality of life after a critical illness, sepsis approach, dysfunction after critical illness and hemodynamic the prevention of cardiac events, epidemiology and monitoring - bedside echocardiography to predict recording of trauma or renal replacement therapy. sepsis mortality. Finally, CriticalMed had worked on the identification of risk factors for disability, cognitive dysfunction and hrqol after severe trauma

CRISTINA GRANJA and implementation of a survey on analgesia, sedation PRINCIPAL INVESTIGATOR and delirium in critically ill patients in order to understand the adherence to international guidelines. cintesis: overview & vision 2018-2022 research groups 19

GeriMHealth – Geriatrics & Mental Health

GeriMHeatlh – Geriatrics & Mental Health is a research Main achievements: Between 2013 and 2017, group of cintesis that includes researchers from researchers participated in 26 projects, 7 international different areas, namely, psychiatrists, rheumatologists, on Ageing, Dementia, bpsd, Delirium, Frailty, Needs oncologists, internal medicine doctors, nurses, social Assessment and Mental Health, Heart Failure, Stroke, assistants, gerontologists and occupational therapists Family Caring and Clinical Trials. A total of 41 articles who develop their work in universities, hospitals, indexed to isi and/or Scopus were published (201 national network of long-term healthcare units and citations; mean 2.31 if). In the last years, this group primary healthcare units. These connections allow has 54 peer-reviewed papers published; 4 international for the implementation of translational research, the and 12 national books/chapters; 3 prizes and 8 projects participation in international research projects and awarded. The pi integrates national/international scientific networks. The objective of the group is to societies in Ageing and Geriatrics, Family Therapy and develop clinical research and solutions addressed rehabilitation. Members also integrate several medical towards physical and mental problems associated societies and International networks and promote to ageing. In this respect, the group advocates for a research line focused on hospitalized older adults’ a multidisciplinary approach oriented towards the delirium and impact on patients/families/staff, in needs of the elderly, their family/caregivers and connection with Intensive Care Medicine Department formal caregivers to improve geriatric care. of a main Portuguese Hospital. This team published papers with validation of delirium screening tools, and associated psychological morbidity.

LIA FERNANDES PRINCIPAL INVESTIGATOR

DEPARTMENT OF PSYCHOLOGY AND EDUCATION U. AVEIRO cintesis: overview & vision 2018-2022 20 research groups

iGO – Health Technology Assessment in Gastrointestinal Oncology

The research group goi is a unique network in the area of translational research and Gastrointestinal BASIC MEDICINE Oncology that gathers together researchers (integrated and collaborators) with different competences, from different medical schools, universities and renowned Main achievements: : igo have won Pfizer prize in institutions working on cancer, such as the Portuguese 2017 with a multicenter study on the real use of nbi Institute of Oncology (ipo) of Porto and the São João (an endoscopic technology) which allows early diagnosis Hospital Centre. Along the last decade, igo has worked of gastric cancer. With this study, involving patients in national and international projects, seeking to from 5 different western countries, it was shown that position itself as an important partner with the capacity the only validated classification available for gastric of recruiting a large number of patients for scientific mucosa can be used on current practice with marked multicentre studies designed to evaluate the different impact on patients’ care. igo team evaluated the outcomes of new and disruptive technologies in the cost-benefit of surveillance of patients at high risk for fields of screening , diagnosis, and the approach to gastric cancer and promoted a screening of gastric gastrointestinal cancer. cancer. All together, these results bring Western attention to gastric cancer as still a relevant disease with significant current and future burden.

MÁRIO DINIS RIBEIRO PRINCIPAL INVESTIGATOR

MicroMed – Medical Microbiology Main achievements: : MicroMed provided additional insights regarding the development of resistance to MicroMed is a research group of cintesis with a great azole and non-azole antifungals, namely propiconazole, national and international economic impact potential, commonly used in agricultural practice. Ultimately, acting in areas like sustainability and food safety or the data will add to a scientific solid background supporting infection control in the hospital context. Their objectives the redefinition of agricultural antifungal control policies. are to develop new diagnosis resources and tools This reasearch team invested on the development, based on new disruptive technology, thus seeking to translation and uptake of existing and evolving complex respond to the emerging problems that threaten our technologies, together with fastinov, a spin-off company. health and quality of life. The innovative approach allows the determination of the susceptibility phenotype in just two hours, versus the 48 h needed at present, filling the huge gap ofast methods available in the market (usa and eu patent ACÁCIO RODRIGUES PRINCIPAL INVESTIGATOR granted). Finally, MicroMed is working on a novel device - DopCer, a central venous catheter doped with Ce(iii). Presently, a patent is being written for submission. cintesis: overview & vision 2018-2022 research groups 21

NeuroGen – Neuronal Degeneration & Regeneration

NeuroGen – Neuronal Degeneration & Regeneration Main achievements: NeuroGen has identified a BASIC MEDICINE is a research group of cintesis aiming to identify and cell group that pays a critical role in olfaction and in understand the mechanisms involved in ageing and in the regulation of olfactory-guided behaviors. It was the development of diseases of the nervous system, namely, demonstrated that lesions of the nucleus of the lateral their determinants and main risk factors. The group is olfactory tract (nlot) leads to dramatic changes in constituted by a multidisciplinary team from the health olfactory functions, including total loss of the sense of field that has studied the way the brain responds to smell, and inability to detect and discriminate odors certain conditions or in front of specific stimuli, with affecting behaviors that are critical to survival and a particular interest in neuronal neuroplasticity and in reproduction. This research group also identified the capacity of regeneration, as well as in the influence estrogen and progesterone receptors involved in the of some substances in the prevention of a number of regulation of motivated behaviors. Studies undertaken age-related neurodegenerative diseases. in the ventrolateral division of the ventromedial nu- cleus, medial preoptic nucleus and bed nucleus of the stria terminalis, using sex hormones and agonists/ antagonists of estrogen receptors, allowed the identification ARMANDO CARDOSO of the receptors, and respective sub-types, involved in PRINCIPAL INVESTIGATOR the hormonal modulation of the neural circuits that mediate social behaviors.

PharmaHTA – Therapeutics, Pharmacovigilance & Hypertension Diagnosis

As part of cintesis, the research group Pharmahta is committed to therapeutics, pharmacovigilance and Main achievements: Pharmahta was involved in hypertension diagnosis. The team of researchers studies more than 100 national and international scientific the epidemiology, detection, collection and assessment events, publishing around 50 papers in the field ofht , of the adverse reactions caused by drugs in the population pharmacovigilance and pharmacoepidemiology and in general, and in the elderly in particular. The objective in the regular organization of National and International is to understand better the safety profile of drugs Meetings and specific training courses onht and currently available in the market, and in the same line, Pharmacovigilance for health professionals and contribute to the implementation of clinical trials, consumers. This group developed strategies promoting namely in the field of cardiovascular diseases. adr reporting using information systems to facilitate the process. In the field of Hypertension, Pharmahta studied the relationship between 24-h blood pressure circadian profiles of Portuguese and Mozambican JORGE POLÓNIA peoples and their relationship with different target organ PRINCIPAL INVESTIGATOR damages. This group also evaluated salt consumption in Portugal, the methodology of its determination and its relationship with kidney failure and stroke. cintesis: overview & vision 2018-2022 22 research groups

TL3: Health Data, Decision Sciences & Information Technologies

PEDRO PEREIRA RODRIGUES PRINCIPAL INVESTIGATOR

2D4H – Secondary Data for Healthcare Research

Secondary Data for Healthcare Research is a research group of cintesis constituted by a multidisciplinary team of specialists in Computer Sciences, Engineering, Main achievements: In 2013-2017, 2d4h new research Mathematics, Economy and Medicine, with the group addressed the problem of burns in Portugal and competences and the experience in the reutilization Brazil, using national hospital administrative data. of secondary data for services and health research Data suggests the optimal number of beds needed for and completely committed to addressing the societal the creation of the first pediatric burn unit in Portugal, challenges related to demography, health and well-being. and its geographic location. Both media impact and The main objective of the group is to develop research new national and international research collaborations that promotes data reutilization for research; health arose from these studies. In another international services performance assessment (including the collaborative effort with Harvard Medical School, a dimensions of effectiveness, efficiency and equality, study on acute myocardial infarction data revealed and the different purposes, such as benchmarking); large disparities regarding the risk of mortality across data quality analysis and the development of tools for hospitals within pt. By analyzing secondary data detecting problems and improving quality of data; the regarding low prevalence diseases, researchers in this spatio-temporal characterization of the weight of a group obtained new and important findings about disease; and research on clinical codification. these conditions, through the characterization of patients’ hospitalizations regarding a broad set of. In addition, translational research regarding abortion related hospitalizations confirmed the expected trend ALBERTO FREITAS since the implementation of the liberalization law PRINCIPAL INVESTIGATOR in 2007, with the ratio hospitalization per abortion decreasing from 1.07 in the year 2000 to 0.11 in the year 2014. cintesis: overview & vision 2018-2022 research groups 23

AI4Health – Artificial Intelligence for Health Care

Artificial Intelligence for Health Care ai4h( ealth) is a Main achievements: ai4health researchers have been research group focused on: a) the advancements in the involved in developing Explainable Artificial Intelligence methods used in Artificial Intelligence (ai) to approach (xai) applications for health care and research. From the increasing prevalence of chronic diseases and its an algorithmic point-of-view, ai4health models have multimorbidities worldwide, b) the application of mostly been based on first-order logic rules and explainable ai methods in health, following the latest Bayesian network models, for diagnosis and prognosis, European directives; and c) interaction of cognitive science which allow both a language and a reasoning to represent and clinical reasoning. The group highlights the great knowledge and explain recommendations in an easily importance of complementing Artificial Intelligence understandable way for healthcare professionals. This research with the attention to the way it will fit in the team developed models in several health domains. complex health ecosystems, namely, through philosophical In order to improve the real-world application of our reflections regarding the nature of the causal medical models, this group developed several web tools: the explanations. The objective of theai4h ealth group is MammoClass, which can predict the probability of a to produce evidence and tools to obtain maximum tumour being malignant, given a small set of demographic profit from artificial intelligence, setting the paths for and findings from mammograms; ExpertBayes, a its integration in health care and research. tool that can take as input expert knowledge in the form of a Bayesian network and refine this network according to a given metric; CrohnBayes, a prognostic tool for Crohn’s disabling disease and reoperation; esdBayes, a prognostic tool for cure and haemorrhage INÊS DUTRA PRINCIPAL INVESTIGATOR after endoscopic submucosal dissection, and skill, a machine learning system that can learn interpretable probabilistic multi-relational models.

ABOVE: ON THE RIGHT: DATA PROCESSING FOCUS ON ARTIFICIAL INTELLIGENCE cintesis: overview & vision 2018-2022 24 research groups

BioData – Biostatistics & Intelligent Data Analysis

The research group BioData ofcintesis aims to increase scientific research related to data analysis and processing and to Biostatistics. The group’s objective is also to assess the application of more modern methods Main achievements: BioData developed, in 2010, in areas such as clinical research and support to decision a new statistical measure, the Information-based making in the field health care delivery. Other purposes measure of disagreement. This statistical measure was include the development of advance training considered useful since it was inserted in the PAIRSetc, programmes,especially with regards to health data a program that compares matched observations and analysis. Therefore, the purpose is to fill the gap that is part of the freeware Winpepi suite of programs for currently exists at the level of graduate professionals epidemiologists. BioData researchers also extrapolate of the field. from biostatistics into modern methods of statistical analysis as, for example, pattern recognition. This knowledge is being used for studying how fetal heart rate features are captured by two different measures

CRISTINA COSTA SANTOS of complexity: entropy and complexity. A team composed PRINCIPAL INVESTIGATOR by members of this group achieved, in 2017, the best results of the Cardiotocogram (ctg) challenge, part of the 2nd Signal Processing and Monitoring (spam) in Labour Workshop, Oxford, United Kingdom. This team succeeded in the identification of fetus at risk, without any medical knowledge.

HEALTH DATA ANALYSIS cintesis: overview & vision 2018-2022 research groups 25

EvidenS&HTA – Evidence-Based Decision Making, Research Synthesis and Health Technology Assessment

EvidenS is a research group of cintesis dedicated to the production and synthesis of quality scientific evidence that can be applied to health care delivery, in Main achievements: During 2013-2017, Evidens&hta combination with national authorities to increase the researchers were founding partners of the Cochrane effectiveness, accessibility, equality, cost-effectiveness Portugal. We are also establishing a similar partnership and sustainability of the Portuguese health system. with the Campbell Collaboration, a sibling initiative Some of the main areas of activity are the development of Cochrane in the social and educational sciences. of patient-centred studies, systematic reviews and Several members of the group are part of the National meta-analysis; the dissemination of the best evidence Commission on Health Technology Assessment, the on relevant health and public health topics; the centrepiece of our national system for hta. Evidens&hta communication of such evidence and counselling of are also part of the methodologist panel of the European decision-makers, authorities and health professionals; Clinical Research Infrastructure Network. Additionally, and finally, the promotion of quality education and this team also collaborated with other partners (e.g. training in this area. Harvard Medical School Portugal Program in Translational Research and Information; uk National Institute for Health and Clinical Excellence). The group

LUIS AZEVEDO provided training, information and advice for several PRINCIPAL INVESTIGATOR stakeholders in ebdm, evidence synthesis and hta and was deeply involved in medical graduate and post-graduate programs. Evidens&hta was also in- volved in initiatives to provide information, advice and knowledge transfer for policy makers, patients and the public, including regular presence in the mass media.

ABOVE: ON THE RIGHT: HEALTH DATA ANALYSIS CLINICAL EVIDENCE cintesis: overview & vision 2018-2022 26 research groups

HIS-EHR – Health Information Systems & Electronic Health Records

Having its origin in the remodelling of the previous In4Health group, the his-ehr group – Health Information Systems & Electronic Health Records aims to develop research in the area of ict processes and technologies, with the objective of delivering quality data that are relevant in the context of medical consultation in healthcare services. The main challenge Main achievements: Over the last years, his-ehr ini- of the group is to develop methods that ensures the tiated collaborations with 6 international institutions, safe storage of patients’ data in terms of semantics, in Europe and South-America, and obtained a total integrity, confidentiality and data availability. The funding over 8.000.000€. his-ehr research group main research topics are the health information systems, contributed to the evolutionary movements of biomedical electronic health records (ehrs), interoperability among simulation and demonstrated several pitfalls in the health information systems, terminologies, cybernetic understanding and use of ultrasound for fetal growth safety, process management and data mining, ehrs assessment by obstetricians, having the potential to information models, telemedicine and eHealth. shape obstetrics care regarding growth restriction or macrosomia diagnoses in Portuguese fetuses and newborns for years. This group contributed to the enhancement of current state of the art access control models that focus only on parts of the much needed RICARDO CORREIA integration of the security and privacy requirements PRINCIPAL INVESTIGATOR of contextual, personal, technical and interactional characteristics that surround the users request within a system or application. In the field of Technologic innovation, his-ehr promoted the creation of 3 spin-off companies: VirtualCare, Healthysystems and is4h.

DELIVERING QUALITY DATA cintesis: overview & vision 2018-2022 research groups 27

NeuroImag – Neuroimaging in Psychiatry and Dementia

The research group NeuroImag, integrated in cintesis, focuses on the areas of signal processing and medical imaging. Its main objective is to develop new and more efficient methods or tools for diagnosis and prognosis, in the context of health services delivery to the population. The ultimate mission of NeuroImag is to contribute, through multidisciplinary research, to a Main achievements: NeuroImag have published better understanding and approach of pathologies the first study using stochastic models of neuronal that affect the human being in the course of life. coupling within the default mode network (dmn) in schizophrenia. Thedmn has been proposed as a major system underlying introspective brain function and consciousness. The study showed that the excitatory influence of the posterior cingulate node on the anterior ANTÓNIO BASTOS-LEITE frontal (af) node of the dmn is, on average, more than PRINCIPAL INVESTIGATOR six times weaker in patients with first episode schizo- phrenia than in healthy control subjects, and that recurrent inhibitory influences of the AF node are likewise reduced to approximately 50% in patients. Another study indicates that registration-based methods applied to serial high-resolution t1-weighted mri can be used to assess brain volume changes in patients with an. These methods are new in the field ofan research and enabled to confirm that assessments of brain volume change may become an additional measure of an severity in the near future. The principal investigator of this research group is co-author of the book Neuroimaging BELLOW, LEFT: BELLOW, RIGHT: MEDICAL IMAGING SIGNAL PROCESSING in dementia (Springer, 2011), a reference textbook in AND MEDICAL IMAGING the field. cintesis: overview & vision 2018-2022 28 research groups

PaCeIT – Patient Centered Innovation and Technologies

paceit – Patient Centered Innovation and Technologies is a research group interested in the design, validation, assessment and implementation of easy-to-use technologies and personalized services, addressed to patients, for diagnosis, classification and management Main achievements: Recently researchers of paceit, of chronic diseases and its risk factors. The main in collaboration with medida and Bloomidea (a digital motivation of the group is to train the patients and media and marketing company), developed the their family in an active participation and InspirerMundi App which aims to achieve good decision-making shared with a team of interdisciplinary clinical results in asthma by transforming adherence caregivers, contributing to the improvement of the to treatment into a positive experience, through quality of life and health efficiency. The diversified gamification, social interaction and image processing. profile of researchers’ experience (health professionals, Team members have led and participated in the engineers, computer programmers and scientist, and Control and Burden of Asthma and Rhinitis study, data scientists) is an important element of this group a nationwide population-based observational and it has played a key role in the success of the latest cross-sectional study that included 858 participants projects, such as the applications mHealth, InspirerMundi, living in over 80 Portuguese cities. paceit team also Allergy Diary and Allergy Monitor. participated on @it2020 - an observational longitudinal multicenter study on the impact of e-Diaries (Allergy monitor App), with a total of 900 patients from Portugal, Spain, France, Italy, Albania, Greece and Turkey. The internationalization of the Control of Allergic Rhinitis and Asthma Test (carat) in more than 15 countries allowed the worldwide dissemination of this patient- JOÃO FONSECA -reported outcome measure, specifically it was included PRINCIPAL INVESTIGATOR in an App in the Netherlands and in clinical studies and awareness activities in Belgium, Germany, Netherlands, South Africa and India. The electronic version ofcarat was included in the Allergy Diary App (available in 22 countries) in the framework of the Twinning project macvia-aria of the European Innovation Partnership on Active and Healthy Ageing. The pediatric version (caratkids) has been used in clinical studies in Netherlands, Brazil, Greece and Thailand.

EASY-TO-USE TECHNOLOGIES cintesis: overview & vision 2018-2022 research groups 29

SPA – Signal Processing Applications

The research groupspa – Signal Processing Applications Main achievements: The main focus ofspa researchers studies the biomedical signal processing. Specifically, has been on cardiotocogram (ctg) - simultaneous the group addresses the development of methodologies recording of fetal heart rate (fhr) and uterine for heart rate and other physiological signals monitoring. contractions - analysis and interpretation, under the The group is also committed to spatio-temporal analysis, scope of the SisPorto project, started in 1987, which using different data sources (for example, time series has the Omniview SisPorto system as one of its main of health events, remote-sensing observations) and outputs. Based on a large retrospective cross-sectional methodologies (for example, spatial statistics, geographic study gender-specific reference charts forctg information systems). The main objectives of this parameters were proposed. Additionally, a prospective group are to develop methodologies for signal longitudinal evaluation of computerized ctg parameters processing / analysis based on the use of traditional throughout pregnancy was performed, including and emerging technologies; contribute to the normal fetuses, small for gestational age and preterm understanding and knowledge of health-related birth fetuses, with a detailed maternal and fetal individual and environmental factors; produce knowledge characterization. This group have recorded simultaneous for preventive health and contribute to the improvement mhr and fhr in the intrapartum, based on which an of personalized diagnosis and treatment. algorithm for mhr computer analysis during labour was developed/evaluated. spa have been developing several studies employing linear and nonlinear/entropy methods aiming to provide complementary indices for

HERNÂNI GONÇALVES the analysis of fhr and mhr variability. PRINCIPAL INVESTIGATOR

EVALUATION OF COMPUTERIZED PARAMETERS cintesis: overview & vision 2018-2022 30 research groups

Tech4edusim – Technologies for Education and Simulation in Healthcare

Constituted by researchers with clinical and technology backgrounds, Tech4edusim – Technologies for Education and Simulation in Healthcare is a new group of cintesis focus on technology research and development applied to education and quality of health care. The main objectives of the group are to develop innovative Main achievements: Members of this group integrated methods and tools, namely, in the field of simulation, a financed consortium project with a total budget over and through qualitative and quantitative measurement 1 m€, aiming the development of a new technological and assessment of their impact in education, and in architecture that supports the operation of simulation knowledge and competence transfer to clinical practice, centres and team training of health-care professionals. taking into consideration the specificities of the Tech4edusim team members have been developing professionals’ various levels of training. Therefore, clinical scenarios and implementing simulation in the group aims to encourage partnerships with the nursing education with resource to low and high tech industry through contacts that promote technology physical simulators and virtual patients, contributing transfer, and develop synergic collaboration with other to the development of clinical virtual simulation. This groups of cintesis. research group promoted the development and introduction of clinical virtual simulation in nursing education and was called to collaborate in sesam - Society in Europe for Simulation Applied to Medicine each - International Association of Communication MIGUEL PADILHA in Healthcare. PRINCIPAL INVESTIGATOR

HEALTHCARE EDUCATION cintesis: overview & vision 2018-2022 research groups 31

RESEARCH FIELDS cintesis: overview & vision 2018-2022 32 evaluation criteria - quality, merit, relevance and extent of internationalization

Evaluation Quality, merit, relevance and extent of Criteria internationalization

Research Activities Funding Advanced Education & Training 1,143 Web of Science- 13 funded projects -indexed articles (almost (over €4M of total cintesis researchers cintesis researchers doubling the expected funding) have created and are also participate in another number of publications 5 were eu-funded coordinating 5 phd 6 phd Programs foreseen in our 2013 5 were in collaboration Programs: cintesis researchers evaluation application) with Industrial-Health, Bioethics coordinate 9 msc Programs Over 40% of articles ict and Food-partners. Clinical and Health cintesis researchers published in q1 journals, Services Research supervised 30% with international None of these projects (pdicss) 120 msc theses co-authors were funded by the fct. Gerontology and 57 phd theses More than 1,600 In fact, during the 2015- Geriatrics Between 2015 to 2017, citations (average impact -2017 period, the unit Nursing Science pdicss students were factor of 3.5) received under 200.000€/ Palliative Care first authors in a total Over 130 books or year from the fct, which A new Doctoral of 270 articles, nearly book chapters was mainly used to Program on Health Data half in q1 journals, and support the scientific Science is set soon to be 25% with international management team. launched supervisors cintesis: overview & vision 2018-2022 evaluation criteria - quality, merit, relevance and extent of internationalization 33

4 Trademarks Dissemination of cintesis nursing Scientific knowledge 2 Copyright registrations researchers developed a and Social Impact 7 Spin-offs, in fields as project to identify health diverse as medical Health & Science literacy levels among education, electronic Communication specific populations. health records, and 881 news published in antibiotic resistance the media Science Literacy Automatic advertising cintesis participated cintesis and its spin-offs value - aav - over €5.9M in the Science and have participated in Consistent presence in Technology Exhibition several national/ 5 social networks of the University of Porto; international consortia cintesis co-promoted – for example, fastinov Health Literacy (together with the Ciência is the first national sme metis and mgFamiliar Partners Viva Agency) the Meeting leading a consortium (www.metis.med.up.pt; “Science, Health, cintesis collaborates funded by the eu to www.mgfamiliar.net) are Communication”; with external private launch on the market cintesis’ online peer-re- cintesis researchers and public national and a kit that, within 60 viewed resources focus- are conducting the first international entities, minutes, determines ing on explaining health study on media coverage including: susceptibility of bacteria issues to laymen. of medical research Health Cluster Portugal to antibiotics. in Portugal. novartis Sanofi Pasteur Astrazeneca Glintt Promptly Marand Veratech Euroscom AgentScape

TT & Innovation

Within the last years, cintesis has created/ registered: 2 Patents 1 Licensing agreement

INTERNATIONALIZATION cintesis: overview & vision 2018-2022 34 evaluation criteria - team’s scientific merit

By participating in several international Team’s projects and collaborating Scientific with different international Merit scientific and societal networks. Some examples are: Impact The integration of cintesis’ scientific cintesis in the Porto results had a substantial Unit of the Portuguese national impact; for Branch of the Iberoame- example: rican Cochrane Centre; Conceiving new The participation percentile reference with a key role of several values for Portuguese cintesis researchers in neonates; International Medical Developing and testing Societies, such as the cintesis contributed a strategy for correcting European Association Inclusiveness to decrease regional and children iodine levels of Allergy and Clinical cintesis contributed institutional inequities on (which was presented Immunology, the European to the research development research, by developing to the Portuguese Society of Gastrointestinal of scientific fields less a strong presence in Parliamentary Health Endoscopy, or the European prone to catch attention all Portuguese regions Commission). Society of Hypertension; (but with large societal (including less urban The creation by impact), such as Primary centers and the islands On the international cintesis researchers of Care, Nursing, Clinical and of Azores and Madeira) field, cintesis has also the Research Department Health Services Research, and by integrating played an important role: and the Portuguese and Public Health; Polytechnic Institutes. By creating asthma Language Countries cintesis has managed questionnaires that have Division of the unesco to foster research, not With this “spreading” to been translated into over Chair in Bioethics; only among physicians, other scientific fields, 20 languages; The regular but also among often- professional areas and By participating in invitations sent to cintesis -neglected professional geographical regions, guidelines definition and researchers to evaluate health fields, such as cintesis has thus multicenter trials (e.g. in the scientific proposals Nurses, Nutritionists, contributed to strengthen fields of Gastroenterology, submitted to the eu, Psychologists, and other the National Scientific Critical Care, and Maternal as well as clinical trials allied health professionals; System. Health). proposed to e-crin.

cintesis: overview & vision 2018-2022 evaluation criteria - adequacy and organization 35

Adequacy and Organization

cintesis works closely NUMBER OF RESEARCHERS PER DISTRICT IN 2017 with 4 main stakeholders: Academic community Healthcare providers Health industry Patients and other Alignment with the members of the national research and general public economic agendas cintesis’ objectives Aiming to: address the ‘Horizontal’ Increase health and ‘Territorial’ Objectives’ prevention knowledge of Portugal 2030. Taking Develop and evaluate advantage of the safer and more efficient overlapping aims of the health interventions National and the European Increase the wider and agendas, cintesis will better use of evidence seek synergies between and information technology regional funding and by healthy individuals, horizon 2020 and 2030. patients and health cintesis aims to professionals consolidate its role as an

cintesis: overview & vision 2018-2022 36 evaluation criteria - adequacy and organization

CINTESIS’ Health Technology Objectives Assessment, and Health Services Research. Research activities cintesis will develop cintesis 3 tl are benchmarks aiming to structured according to assess research impact, national and international including: health research priorities, fct investment per agendas and 2030 Horizon. obtained citation; These alignments provide Investment per opportunities not only research discussed in for obtaining funding, the mass media; but also for cintesis to Proportion of expand its international publications with young prominence, particularly by: researchers as first author; international reference in and engagement with Becoming an Number of prizes per Gastrointestinal Oncology, patients and other members international reference in projects developed. Inflammatory Bowel of the general public. such fields as Health Data Advanced education Disease and Asthma, and partnerships with industry, Science and Digital Health, and training become an international and engagement with Fostering large cintesis aims to reference in several other patients and other members multinational and consolidate its role as fields such as Health Data of the general public. multicenter observational a leading provider of Science and Digital Health. cintesis aims to studies; advanced education cintesis is set to produce high-quality Working towards its programs in emerging areas maintain its leading role and innovative research, inclusion in eu-funded of knowledge, mostly by: in fields as Nursing, besides having a positive projects, particularly in Fostering a higher Primary Care and impact on society as a the fields of Critical Care, impact of research Evidence-Based Medicine. whole and: Oncology, Cardiovascular developed under the These goals are not limited Contributing to and Ageing. aegis of these programs; to the production of strengthen the National cintesis is set to Increasing the proportion research outputs, but Scientific System; consolidate its role as of international students. also involve students and Contributing to the national reference in This will contribute to researchers in advanced sustainability and safety several areas, including improve the skills and education and training, of the National Health some often-neglected knowledge of cintesis provision of knowledge System; research fields, such as members, as well as to transfer services and Decreasing health Nursing, Primary Care, cement its role as leader partnerships with industry, inequities. Geriatric Mental Health, in several areas of knowledge. cintesis: overview & vision 2018-2022 evaluation criteria - adequacy and organization 37

In order to accomplish and professional equity implementation of Raising awareness these aims, the cintesis in access to the scientific knowledge for the importance of course of action will rely on: aforementioned in society; funding research. Supporting the training educational activities. Developing outreach of young researchers activities aiming to raise Knowledge transfer through advanced Dissemination of awareness and educate cintesis aims to be education programs scientific knowledge the general public about a relevant partner in under the responsibility and societal impact the main subject areas of national and international of cintesis; cintesis aims to each tl. page 7 consortia with healthcare Promoting and assure that its scientific A good scientific industry and smes. organizing educational activity has a positive communication is page 8 activities to improve impact on society as a expected to have a skills and knowledge on whole, by: positive impact in: Infrastructures practical matters, such Developing society- Promoting scientific cintesis aims to as funding applications, -centered research activities; literacy; strengthen its research research methods and Developing technology Promoting the adoption support infrastructures. scientific publishing; to be used by everyone of evidence-based decisions page 8 Assuring regional and in research by policy stakeholders;

ON THE LEFT: BELLOW, LEFT: BELLOW, RIGHT: PORTUGAL EHEALTH SUMMIT SCIENCE AND TECHNOLOGY BLENDED LEARNING LISBON, 2018 EXHIBITION OF THE UNIVERSITY INTRODUCTION TO CLINICAL OF PORTO (MOSTRA UP), 2018 STUDIES CLASS, 2017 cintesis: overview & vision 2018-2022 38 research groups

MEETING “SCIENCE, HEALTH, COMMUNICATION”, 2017 cintesis: overview & vision 2018-2022 institutions 39

MEETING “SCIENCE, HEALTH, COMMUNICATION”, 2017

INSTITUIÇÃHOST INSTITUTIONO DE ACOLHIMENTO - Faculdade de Medicina da Universidade do Porto

INSTITUIPARTICIPATINGÇÕES PA INSTITUTIONSRTICIPANTES

REGINORTHÃO REGIONNORTE REGICENTRALÃO CENTR REGIONO - Agrupamento de Escolas Dona Maria II - Centro de Investigação e Desenvolvimento Vila Nova de Famalicão da Beira - Centro de Atendimento e Serviços 50+ - Instituto Politécnico de Coimbra

- Centro de Dermatologia Epidermis, Lda. - Instituto Politécnico da Guarda - Centro Hospitalar do Alto Ave, EPE/ - Instituto Politécnico de Leiria - Hospital Senhora de Oliveira , Guimarães Instituto Politécnico de Viseu - Centro Hospitalar do Porto, EPE - Instituto Português de Oncologia de Francisco - Centro Hospitalar do São João, EPE - Gentil, Centro Regional de Oncologia de Coimbra - Educação e Ensino Superior do Alto Ave - Universidade de Aveiro - Escola Superior de Enfermagem da - Universidade de Coimbra Cruz Vermelha Portuguesa de Oliveira de Azeméis - Universidade da Beira Interior - Escola Superior de Enfermagem do Porto - Escola Superior de Enfermagem de Vila Real/UTAD - Escola Superior de Enfermagem Dr. José Timóteo Montalvão Machado REGISOUTHÃO REGIONSUL - Escola Superior de Saúde de Santa Maria - Administração Regional de Saúde de Lisboa e Vale - Faculdade de Ciências da Nutrição e Alimentação do Tejo, I.P. da Universidade do Porto - Instituto Politécnico de Santarém - Faculdade de Ciências da Universidade do Porto - Faculdade de Ciências Médicas/ - Faculdade de Psicologia e Ciências da Educação Nova Medical School - Universidade Nova de Lisboa da Universidade do Porto - Universidade Atlântica - FASTINOV, S.A. - Universidade do Algarve - Hospital CUF Porto, S.A. - Hospital de Braga - Hospital de Santa Maria Maior, EPE ILHASISLANDS - Hospital Magalhães Lemos, EPE - Universidade da Madeira - Hospital Pedro Hispano (Unidade Local de Saúde - Universidade dos Açores de Matosinhos, EPE) - Instituto de Ciências Biomédicas Abel Salazar - Instituto Politécnico de Bragança - Instituto Politécnico do Porto

- Instituto Politécnico de Viana do Castelo - MEDIDA - Serviços em Medicina, Educação,

- Investigação, Desenvolvimento e Avaliação, Lda - Ordem Terceira de São Francisco - Unidade de Saúde Local do Alto Minho - Universidade Fernando Pessoa cintesis: overview & vision 2018-2022 40 abbreviations & acronyms

2d4h: Secondary Data for Healthcare Research eHealth: Study and research field in the intersection of medical informatics, public health and business, A referring to health services and information delivered aav: Automatic Advertising Value (measurement or enhanced through the Internet and related regarding the costs for equivalent editorial/ technologies1 advertisement space in different Media) esep: Escola Superior de Enfermagem do Porto af: Anterior Frontal (like in Anterior Frontal Node) (Nursing School of Porto) Ageingc: AgeingCluster eu: European Union ai: Artificial Intelligence Evidens&hta: Evidence-Based Decision Making, ai4health: Artificial Intelligence for Health Care Research Synthesis and Health Technology Assessment aids: Acquired Immune Deficiency Syndrome an: Anorexia Nervosa F fct: Fundação para a Ciência e a Technology B (Portuguese Government Science & Technology BioData: Biostatistics & Intelligent Data Analysis Funding Body) bpa: Bisphenol A fcup: Faculdade de Ciências da Universidade do Porto (Faculty of Sciences of the University of Porto) C fhr: Fetal Heart Rate carat: Control of Allergic Rhinitis and Asthma Test fmup: Faculdade de Medicina da Universidade do CardioCare: Cardiovascular Sciences Porto (Faculty of Medicine of the University of Porto) Charter: Challenges and Strategies in Health Research CriticalMed: Critical Care & Emergency Medicine G csb: Centro de Simulação Biomédica (Biomedical GeriMHealth: Geriatrics & Mental Health Simulation Center at the Faculty of Medicine of the University of Porto) H ctg: Cardiotocogram his-ehr: Health Information Systems & Electronic Health Records D horizon (2020/2030): European Research and dmn: Default Mode Network Innovation programme covering a number of years the referred years E hrq ol: Health Related Quality of Life each: International Association for Communication hta: Health Technology Assessment in Healthcare ebdm: Evidence-Based Decision Making I e-crin: European Clinical Research Infrastructure icbas: Instituto de Ciências Biomédica Abel Salazar Network da Universidade do Porto (Abel Salazar Institute of edc: Endocrine Disrupting Chemicals Biomedical Sciences of the University of Porto) eea: European Economic Area ict: Information and Communication Technology if: Impact Factor

1 Eysenbach G. What is e-health? J Med Internet Res. 2001 Jun;3(2):e20. doi: 10.2196/jmir.3.2.e20. cintesis: overview & vision 2018-2022 abbreviations & acronyms 41

igo: Health Technology Assessment in Q Gastrointestinal Oncology q1: First Quartile (regarding top 25% of the Impact Factor distribution of scientific publications) M ManEthics: Healthcare Management & Ethics R metis: Online platform containing health rg: Research Group information written in plain Portuguese aiming rl: Research Line to increase health literacy in general public mhr: Maximum Heart Rate S MicroMed: Medical Microbiology Scopus: Abstract and citation database of peer- mri: Magnetic Resonance Imaging -reviewed literature of the publishing company msc: Master of Science Elsevier mt: Management Team sesam: Society in Europe for Simulation Applied to Medicine N sme: Small and Medium Enterprise mbi: Narrow Band Imaging spa: Signal Processing Applications NeuroGen: Neuronal Degeneration & Regeneration spam: Signal Processing and Monitoring NeuroImag: Neuroimaging in psychiatry and dementia ssc: Scientific Steering Committee nlot: Nucleus of the Lateral Olfactory Track nucre-3ds: Nursing Clinical Reasoning Education T – 3d Simulation Tech4edusim: Technologies for Education NursID: Innovation & Development in Nursing and Simulation in Healthcare tl: Thematic Line P PaCeIT: Patient Centered Innovation and Technologies U pairsetc: Computer Program used in Epidemiology for UAlgarve: Universidade do Algarve (University comparisons of paired and other matched observations of Algarve) pdicss: Programa Doctoral em Investigação Clínica UAveiro: Universidade de Aveiro (University e em Serviços de Saúde (phd program in clinical and of Aveiro) health services research) uc: Unit Coordinator Pharmahta: Therapeutics, Pharmacovigilance & UMadeira: Universidade da Madeira (University Hypertension Diagnosis of Madeira) phd: Doctor of Philosophy unesco: United Nations Educational, Scientific pi: Principal Investigator and Cultural Organization pku: Phenylketonuria PrimeCare: Primary Health Care Research W ProNutri: Clinical Nutrition & Disease Programming wos: Web of Science pt: Portugal pt2030: Portuguese Government Program of Investment X xai: Explainable Artificial Intelligence cintesis: overview & vision 2018-2022 42 researchers

Nuclear cv Carlos Alberto da Cruz Sequeira Altamiro Manuel Rodrigues da Costa Pereira Carlos Jorge Cabral Vaz Cidália Irene Azevedo Pina Vaz Carlos Manuel da Silva Martins João Almeida Lopes Fonseca Carmen Maria da Silva Maciel Andrade João Francisco Montenegro Andrade Lima Bernardes Carmen Maria Lisboa Silva Jorge Manuel Silva Junqueira Polónia Catarina Maria Rodrigues Afonso da Cruz José Carlos Magalhães Silva Cardoso Catarina Pires da Rosa José Luís Dias Delgado Catarina Vieira Moniz Alves Neves Luís Filipe Ribeiro de Azevedo Célia Maria Amorim Costa Maria Conceicão Costa Pinho Calhau Célia Samarina Vilaça de Brito Santos Maria Constança Leite de Freitas Paúl dos Reis Torgal Cláudia Camila Rodrigues Pereira Dias Maria Cristina Granja Teixeira Santos Cláudia Sofia Fonseca Marques Maria Dulce Cordeiro Madeira Clemente Neves de Sousa Mário Jorge Dinis Ribeiro Corália Maria Fortuna de Brito Vicente Osvaldo José Coutinho Correia Cristiane Pavanello Rodrigues Silva Pedro Pereira Rodrigues Cristina Isabel Oliveira Jácome Cristina Maria Correia Barroso Pinto Cristina Maria Medeiros Guedes Ferreira Moura Integrated Researchers holding a phd Cristina Maria Nogueira da Costa Santos Acácio Agostinho Gonçalves Rodrigues Daniela Maria Pias de Figueiredo Agostinha Esteves de Melo Corte Diana Maria Veloso e Silva Alberto Augusto Oliveira Pinto Hespanhol Diogo Francisco Santos Silva Pestana Alcinda Maria Sarmento do S. Costa dos Reis Elisa Oliveira Braga Keating Alexandrina Maria Ramos Cardoso Elisabete Maria das Neves Borges Alzira Teresa Vieira Martins Ferreira dos Santos Elisabete Travassos Araújo Ricardo Amadeu Matos Gonçalves Elizabete Maria Ferraz Loureiro Ana Carina Martins Pereira Emanuel Castro Cassoco Caumbela Ana Carla Seabra Torres Pires Emília da Conceição Torres Dias Moreira Ana Cristina de Spínola Costa Maymone Madeira Ermelinda Maria Bernardo Gonçalves Marques Ana Isabel Silva Dias Fernanda Inês de Carvalho Pereira Ribeiro Vaz Ana Leonor Alves Ribeiro Filipa Daniela Correia Marques Ana Luísa Fernandes Neves Soares Francisco António Portilha Antunes da Cunha Ana Manuela Onofre Meireles Gil Filipe Ramada Faria Ana Margarida Leite de Almeida Ferreira Goreti Filipa Dos Santos Marques Ana Paula Prata Amaro de Sousa Guilhermina Maria da Silva Rêgo Ana Reynolds Magalhães A. C. Castro Saraiva Hélia Maria da Silva Dias Ana Sofia Quinta e Costa Neves Oliveira Morais Henriqueta Ilda Verganista Martins Fernandes Ana Teresa Pinto e Silva Herlander José Resende Marques Anabela Gonçalves Silva Hernâni Manuel da Silva Lobo Maia Gonçalves André Filipe Morais Pinto Novo Hortense Maria Tavares Simões Cotrim André Rosa Biscaia Inês de Castro Dutra Andreia Sofia da Costa Teixeira Inês Rosendo Carvalho e Silva Caetano António José de Almeida Soares Irene Maria Palmares Dias Carvalho António José de Bastos Leite Isabel Maria Abreu Rodrigues Fragoeiro António José Mónica da Silva Guerra Isabel Maria Teixeira de Carvalho Pedroto António Luís Rodrigues Faria de Carvalho Isilda Maria Oliveira Carvalho Ribeiro Armando Cardoso Ivone Maria Resende Figueiredo Duarte Carla Dolores Rodrigues Carvalho de Sá Couto Jorge Manuel Tavares Canena Carla Maria Barreto da Silva de Sousa Rego José Alberto da Silva Freitas Carla Maria Gomes Marques de Faria José Anibal Ribeiro da Fonte Carla Sílvia Neves da Nova Fernandes José Augusto Rodrigues Simões cintesis: overview & vision 2018-2022 researchers 43

José Carlos Marques de Carvalho Maria Margarida da Silva Reis dos Santos Ferreira José Gerardo Gonçalves de Oliveira Maria Margarida da Silva Vieira Ferreira José Ignacio Guinaldo Martin Maria Rui Miranda Grilo Correia de Sousa José Manuel Carraça da Silva Mariana Ferreira Couto José Miguel dos Santos Castro Padilha Marisa Lobo Lousada José Paulo Alves Vieira de Andrade Marta Sofia de Sousa Pinto José Pedro Castro Leão Neves Matilde Filipa Monteiro Soares José Pedro Lopes Nunes Miguel Bernardo Ricou da Costa Macedo Júlio César Leite da Fonseca Rocha Miguel Laranjeira Rodrigues de Areia Kristof Rene Gerarda Raemdonck Nuno Pedro Garcia Fernandes Bento Borges Laetitia da Costa Teixeira Olga Maria Freitas Simões de Oliveira Fernandes Lia João de Pinho Araújo Olga Maria Pimenta Lopes Ribeiro Lia Paula Nogueira Sousa Fernandes Óscar Manuel Soares Ribeiro Lígia Maria Monteiro Lima Otília Maria da Silva Freitas Liliana Xavier Marques de Sousa Ovídio Antonio Pereira da Costa Luís Filipe Duarte Reino Cobrado Paula Cristina Santos Pinto Luísa Maria Barbosa de Sá Paulino Artur Ferreira de Sousa Luísa Maria da Costa Andrade Paulo Alexandre Azevedo Pereira Santos Mª Nilza Guimarães Nogueira de Caldevilla Paulo Alexandre Oliveira Marques Manuel Alberto Morais Brás Paulo Alexandre Puga Machado Manuel Belchior Campelo Pedro Alberto da Graça Pereira Manuel Guilherme Gonçalves Macedo Pedro Filipe Vieira Pimentel Nunes Manuel Joaquim de Brito Passos Pedro Manuel Carvalho Machado dos Santos Manuel Jorge Fontoura Pinheiro de Magalhães Pedro Manuel Vieira Marques Manuel José Ferreira de Magalhães Priscila Alves Maranhão Margarida da Silva Neves de Abreu Ramiro Filipe Barbosa Veríssimo Margarida de Melo Cerqueira Ricardo Filipe Gonçalves Martinho Margarida Isabel Rolland de Lima Sobral Ricardo Filipe Sousa Santos Maria Alice Correia de Brito Ricardo João Cruz Correia Maria Celeste Bastos Martins de Almeida Ricardo Jorge Marcos Pinto Maria Celeste de Sousa Silveira Ricardo Manuel de Pinto Vaz Maria Cristina Thierstein R. Duarte Teixeira Santos Rita Daniela Teixeira dos Santos Maria da Piedade Moreira Brandão Rosa Maria Vilares Araújo dos Santos Maria de Fátima Araújo Lopes Elias Rosa Marina Lopes Brás Martins Afonso Maria do Céu Aguiar Barbieri de Figueiredo Rui Manuel Lopes Nunes Maria Helena de Oliveira Penaforte Rute Alexandra Borges de Almeida Maria Henriqueta de Jesus Silva Figueiredo Sandra Maria Caldas da Silva Mouta Maria Irene Mendes Pedro Santos Sara Maria Oliveira Pinto Maria Isabel Bica Carvalho Costa Sara Otília Marques Monteiro Maria João Filomena dos Santos Pinto Monteiro Sara Raquel Costa Guerra Maria João Tinoco da Costa Azevedo Sergio Manuel Moreira Sampaio Maria José Carvalho Nogueira Sónia Patrícia Vilar Martins Maria José da Silva Peixoto de Oliveira Cardoso Susana Isabel Ferreira da Silva de Sá Maria José Espinar Gili Susana Maria Sousa Silva Ferreira Maria José Silva Lumini Landeiro Tiago António Queirós Jacinto Maria Júlia Costa Marques Martinho Vera Mafalda Gomes Duarte Maria Luciana Gomes Domingues Couto Carvalho Victor Filipe Gomes Certal Maria Luísa de Morais e Sousa de Castro Victor Manuel Conceição Viana Maria Manuel da Silva Azevedo Wilson Jorge Correia Pinto de Abreu Maria Manuela Ferreira Pereira da Silva Martins Maria Manuela Henriques Pereira Ferreira cintesis: overview & vision 2018-2022 44 researchers

Integrated Researchers not holding a phd Sónia Cristina Antunes dos Santos phd Student Susana Manuela Rocha Barbosa Tiago Rafael Ganhão Pereira Vieira Pinto Amélia Susana dos Santos Brandão Tavares Ana Catarina Trindade Certo Ana Cláudia Pereira Bártolo Integrated Researchers not holding a phd Ana Isabel Alves de Sá e Sousa Other Integrated Member Ana Margarida Barbosa Ribeiro Pereira Alda Rosa Barbosa Mendes Ana Marta Matos Silva Ana Isabel Carvalho Teixeira Ana Rita Leal Ferreira Ana Jorge Santos Marques André Luís Charro Ramalho Ana Lídia Rouxinol Sampaio Dias António da Luz Pereira Ana Margarida Mostardinha Alves Murteiro Bárbara Costa Pereira Antunes Ana Maria Oliveira Ferreira Gomes Bernardo Manuel de Sousa Pinto Ana Sofia Oliveira Santos Bruno Tiago dos Santos Guimarães André Emanuel Moreira do Rosário Carla Sofia Roma de Oliveira António Alberto Cerqueira da Silva Dias Caroline Sobral Dahlem António Joaquim Rocha Festa Cláudia Maria Sobral Azevedo Bárbara Torres Mota Daniel José Nunes Madureira da Cunha Bernardo Rocha Pinho Daniel Párraga Núñez Berta Sousa Daniela Filipa Ferreira dos Santos Bruno Melica Daniela Filipa Soares Brandão Bruno Miguel Ferreira de Oliveira Diana Sofia Antunes Bordalo Carlos Alberto Ferreira Pinto Diogo Miguel Pereira Libânio Monteiro Carlos Miguel Magalhães Vítor Fernando Maria Pacheco Cunha Osório Araújo Cátia da Luz Pires Gustavo Marísio Bacelar da Silva Cristina Maria Inocência Imaginário Hugo Manuel Ribeiro Teixeira Daniel Martinho Ferreira Dias Isabel Alexandra da Costa Pereira de Castro Silva Duarte Nuno Gonçalves Ferreira Isabel Cristina Santos Silva de Faria Ramos Egídio Samuel Luizinho Frade Joana Alexandra Vilarinho Branco Eliana Luísa Martins Gonçalves Joana Isabel Oliveira Mendes Marques Eliana Sofia Maia Amorim de Sousa João Augusto Pinho da Costa das Neves Viana Fernanda Maria Ferreira de Carvalho João Manuel Monteiro dos Santos Fernando José Oliveira Lopes João Vasco Nunes dos Santos Filipe Ferreira Moreira José Daniel Machado Rodrigues Francisco Bischoff Luís Miguel Ribeiro Nogueira Soares da Silva Francisco José Correia Graça Almeida Mafalda Santiago Alves Pereira Francisco Miguel Correia Sampaio Maria Isabel Pires Jesus Pereira Gilberta Maria França Sousa Maria João Bacelar Pinto Coelho de Aguiar Giovana Jaskulski Gelatti Mariana Fernandes Lobo Isilda Maria Ferreira Couto Marisa Isabel Garcia Rodrigues Ivânia Martins Gonçalves Milaydis Sosa Napolskij Joana Cláudia Parente Ferreira Natália Sofia Correia Duarte Joana Filipa Borges da Cunha Ferreira Olga Estrela Teixeira da Silva Magalhães Joana Muchagata Madeira Duarte Patrícia Rosa Sousa Alves João Manuel Fernandes Rodrigues Paula Cristina Amaro Abrantes e Sousa Jorge Abel Jácome Gomes Rita da Silva Amaral Jorge Manuel Félix Cardoso Rosa Maria de Sousa Andias José Afonso Gago Martins da Rocha Rui Nuno Machado Guimarães José Carlos Ferreira Valente Sara Sofia Abreu Ferreira Alves Júlio César Botelho de Souza Sílvia Inês de Castro Moreira Liliana Isabel Tavares Rosário cintesis: overview & vision 2018-2022 researchers 45

Liliane Vélia Ferreira Mendonça Ana Luísa Balonas Barbosa Luís Filipe Correia Soares dos Reis Ana Maria Barros Pires Luís Miguel Correira Ferreira Ana Maria Costa Jardim de Azevedo Luís Miguel Vieira de Araújo Ana Maria Vieira Soares de Resende Manuel António Gonçalves de Pinho Ana Paula Calado Baptista Enes de Oliveira Marcos Luiz de Paula Bueno Ana Paula dos Santos Jesus Marques França Maria Beatriz da Silva Pereira Ferro Ana Paula Jesus Domingues Guilherme Maria Conceição Marinho S. Ribeiro Oliveira Reisinho Anabela Maria Sousa Pereira Maria da Conceição Fernandes Santiago André Rodrigues Pinho Maria Isabel de Sousa Garcia Lema Anita Oliveira Marques Maria Isabel Ventura Araújo Moreira António de Almeida e Sousa Cardoso Fernandes Maria Jacinta Pereira Dantas Aurora Maria Vivas de Andrade Santos Abreu Mariana dos Ramos Oliveira Beatriz Simão Parreira Mariana João Tiago Meireles Pereira Brenda Eugénia Carvalho de Moura Cardoso Marisa Juliana Leite Guimarães Bruno Miguel Raposo Távora de Barros Peixoto Marlene Lebreiro da Silva Bruno Miguel Silva Moreira Nuno Miguel Teixeira de Sousa Carlos Alberto Correia Carreto Olívia Lourenço de Matos Carlos Fernandes da Silva Palmira da Conceição Martins de Oliveira Carlos Manuel Milheiro de Oliveira Pinto Soares Patrícia Daniela Barata Gonçalves Catarina Cardoso Tomás Pedro Ferreira Farinha Silva Célia Maria Abreu de Freitas Pires Pedro Luís Gonçalves Cavaleiro Clarinda Maria de Castro Neves Pedro Paulo dos Santos Sacadura Cláudia Alexandra Teixeira Azevedo Ricardo Lourenço dos Santos Claudia da Matta Coelho Rui António da Cruz Vasconcellos Guimarães Cristiano Inácio Lemes Rui Filipe Alves Pinto Cristina Freitas Carvalho Sousa Pinto Rui Manuel da Silva Pereira Neiva Dalila Maria Rodrigues Gonçalves Veiga Mora Rui Miguel Sá Maia Guedes Daniel Cláudio Pereira Rui Valdiviesso de Miranda Santa Denise Rocha Araújo Sónia Manuela Almeida Teixeira Diana Carolina de Jesus Santos Luzio Soraia Teles de Sousa Diana Filipa Garrido Azevedo Maia Tiago Miguel Gonçalves Marques Diana Marina da Silva Teixeira Tiago Nuno Silva e Costa Diogo de Matos Graca Ayres de Campos Vera Lúcia Alonso Pires Duarte Manuel Veiga Dias Ferreira Virgínia Maria Sousa Guedes Eva Lau Gouveia Ezequiel Martins Carrondo Collaborator Fernanda Maria Mendes de Andrade Abel Filipe Santiago Nicolau Fernanda Sofia Quintela da Silva Brandão Abílio António Cardoso Teixeira Fernando Ricardo Ferreira Santos Alexandra Isabel Coelho de Sousa Francisco Nuno Rocha Gonçalves Alexandra Mónica Almeida Miquelino Miranda Gorete Maria Pereira dos Santos Alexandra Paula Costa Freitas Gregório Magno de Vasconcelos de Freitas Alfredo Mendes de Castro Helder Manuel Casal Cardoso Álvaro Manuel Reis da Rocha Helena Maria de Sousa Lopes Reis do Arco Ana Cardoso Allen Gomes Helena Sofia Garcia Fonseca Ana Cristina Fernandes Lopes Inês Maria Moreira Guedes Maia Nunes Ana Filipa Bastos Pedrosa Inês Martins Esteves Ana Filomena de Matos Natividade Carvalho Isabel Alexandra Marcos Miranda Ana Isabel Fernandes Querido Isabel Maria Barbas dos Santos Ana Isabel Gonçalves Faria Isabel Maria dos Santos Carvalho Gomes da Silva Isaura do Carmo Dias Moreira Carvalho cintesis: overview & vision 2018-2022 46 researchers

Joana Filipa Paula Lourenço Oriana Horta Rendeiro Correia Pinto Joana Madalena Tavares Martins Guedes Patrícia Meireles Henriques de Castro Joana Margarida Moutinho Barbosa Patrick Alexandre Barbosa Alves Joana Maria Barros Barbosa Paula Cecília Costa Egipto da Fonseca João Carlos Winck Fernandes Cruz Pedro Daniel Costa Dias João Filipe Fernandes Lindo Simões Pedro Manuel Henriques da Cunha Abreu João Luis Alves Apóstolo Pedro Miguel Alves Brandão João Manuel Portela Gama Pedro Miguel de Almeida Melo João Nuno Marques Parracho Guerra da Costa Pedro Nuno Silva Coutinho Marques Neves João Nuno Páris Couto da Costa Leite Pedro Nuno Valente Reis Pereira João Pedro Pinto de Almeida Freitas Raquel Cristina Barroso Marques da Costa Jose Adelino Mesquita Bastos Raul Alberto Carrilho Cordeiro José António Saraiva Ferraz Gonçalves Renata Vila Nova da Silva José Carlos da Silva Caldas Rita Manuela de Almeida Barros José Edmundo Xavier Furtado de Sousa Rosa Celeste dos Santos Oliveira Jose Manuel Coelho Ribeiro Rosa Maria Mendes Ferreira José Maria Tourais Matos Sousa Rúben Sá Balão Alves Rocha Josefa das Neves Simões Pandeirada Rui Carlos Camacho Sousa Ferreira Silva Lia Raquel Teixeira de Sousa Rui Jorge Dias Costa Lídia Sousa Rui Pedro Charters Lopes Rijo Lígia Leão Pimentel Rui Pedro Gomes Pereira Liliana Margarida Mendes de Jesus Sandra Carla Ferreira Leal Luciana Patrícia Martins Nunes Pereira Albuquerque Sandra Cristina de Oliveira Soares Luís Filipe Coelho Antunes Sandra Maria Resende Amorim Luís Manuel Coelho Monteiro Sérgio Filipe Maia de Sousa Luís Miguel Coelho de Sousa Sérgio Lopes Mariano Machado Leite Luís Pedro de Sousa Ramos Monteiro Sílvia Ferreira Dias Magda Mónica Martins Rocha Sofia Ribeirinho Soares Ferreira Leite Manuel José Viana Gonçalves da Costa Susana Elisabete Pereira Bertoquini Maria Antónia Moreira Nunes da Costa Susana Filipa Ganhão Arranhado Maria Clementina de Freitas Nóbrega Morna Susana Paula Gomes Amorim Barbosa de Sousa Maria Cristina Freire Araújo da Cruz Tânia Manuel Moço Morgado Maria da Graca Pereira Alves Teresa Maria da Costa Cardoso Maria do Céu Ribeiro Lamas Teresa Sarmento Henriques Maria do Rosário Lima Curral Teresa Silveira Lopes Maria Gorete Mendonça dos Reis Tiago de Oliveira Paiva Maria Helena de Agrela Gonçalves Jardim Tiago Fernando da Silva Martins Maria João Soares Rodrigues de Sousa Fernandes Tiago Filipe Mota Coelho Maria Manuela Pereira Fonseca Tiago Salgado de Magalhães Taveira Gomes Maria Margarida Santana Fialho Sim-Sim Verónica Alexandra Poveda Padilla Maria Salomé Reis Silva Virgínia Maria Monteiro da Cruz Fernandes Mariana Isabel Cruz Rei Zaida Borges Charepe Mário Joaquim Carmo Pereira Pinto Marlene Cristina Neves Rosa Marta Maria de Pinho Dias Oliveira Carvalho Monteiro Mavilde Rodrigues Arantes da Silva Longarito Michael André Pinto Domingues Mônica Braúna Alencar Leão da Costa Nuno Manuel Ferreira de Sousa de Azevedo Cerqueira Nuno Teodoro da Veiga Reis Bettencourt de Sousa Odete Sofia da Silva Lomba de Araújo cintesis: overview & vision 2018-2022 notes 47

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