Multiple Roles of Ret Signaling in Mechanosensory Neuron Development
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Somatosensory Systems
Somatosensory Systems Sue Keirstead, Ph.D. Assistant Professor Dept. of Integrative Biology and Physiology Stem Cell Institute E-mail: [email protected] Tel: 612 626 2290 Class 9: Somatosensory System (p. 292-306) 1. Describe the 3 main types of somatic sensations: 1. tactile: light touch, deep pressure, vibration, cold, hot, etc., 2. pain, 3. Proprioception. 2. List the types of sensory receptors that are found in the skin (Figure 9.11) and explain what determines the optimum type of stimulus that will activate each. 3. Describe the two different modality-specific ascending somatosensory pathways and note which modalities are carried in each (Figure 9.10 and 9.13). 4. Describe how it is possible for us to differentiate between stimuli of different modalities in the same body part (i.e. fingertip). Consider this at the level of 1) the sensory receptors and 2) the neurons onto which they synapse in the ascending sensory systems. 5. Explain how one might determine the location of a spinal cord injury based on the modality of sensation that is lost and the region of the body (both the side of the body and body part) where sensation is lost (Figure 9.18). 6. Describe how incoming sensory inputs from primary sensory axons can be modified at the level of the spinal cord and relate this to the mechanism of action of some common pain medications (Figure 9-18). 7. Describe the homunculus and explain the significance of the size of the region of the somatosensory cortex devoted to a particular body part. Cerebral cortex Interneuron Thalamus Interneuron 4 Integration of sensory Stimulus input in the CNS 1 Stimulation Sensory Axon of sensory of sensory receptor neuron receptor Graded potential Action potentials 2 Transduction 3 Generation of of the stimulus action potentials Copyright © 2016 by John Wiley & Sons, Inc. -
Signalling Between Microvascular Endothelium and Cardiomyocytes Through Neuregulin Downloaded From
Cardiovascular Research (2014) 102, 194–204 SPOTLIGHT REVIEW doi:10.1093/cvr/cvu021 Signalling between microvascular endothelium and cardiomyocytes through neuregulin Downloaded from Emily M. Parodi and Bernhard Kuhn* Harvard Medical School, Boston Children’s Hospital, 300 Longwood Avenue, Enders Building, Room 1212, Brookline, MA 02115, USA Received 21 October 2013; revised 23 December 2013; accepted 10 January 2014; online publish-ahead-of-print 29 January 2014 http://cardiovascres.oxfordjournals.org/ Heterocellular communication in the heart is an important mechanism for matching circulatory demands with cardiac structure and function, and neuregulins (Nrgs) play an important role in transducing this signal between the hearts’ vasculature and musculature. Here, we review the current knowledge regarding Nrgs, explaining their roles in transducing signals between the heart’s microvasculature and cardiomyocytes. We highlight intriguing areas being investigated for developing new, Nrg-mediated strategies to heal the heart in acquired and congenital heart diseases, and note avenues for future research. ----------------------------------------------------------------------------------------------------------------------------------------------------------- Keywords Neuregulin Heart Heterocellular communication ErbB -----------------------------------------------------------------------------------------------------------------------------------------------------------† † † This article is part of the Spotlight Issue on: Heterocellular signalling -
Pacinian Corpuscle Neuroma: a Rare Case Report with Review of Literature
vv ISSN: 2641-3116 DOI: https://dx.doi.org/10.17352/ojor CLINICAL GROUP Received: 03 June, 2020 Case Report Accepted: 26 June, 2020 Published: 27 June, 2020 *Corresponding author: Sujit Kumar Singh, Junior Pacinian corpuscle neuroma: A Resident, Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak, India, Tel: +91-9477943631; E-mail: rare case report with review of ORCID: https://orcid.org/0000-0002-2285-6905 Keywords: Pacinian corpuscle; Neuroma; Pacinian Literature corpuscle Sujit Kumar Singh1*, Umesh Yadav2, Ajay Sheoran2, RC https://www.peertechz.com Siwach3, Ashish Devgan3, Kshitish Chandra Behera4, Amandeep Verma1, Karunesh Ranjan1 and Surinder Jaiswal5 1Junior Resident, Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak, India 2Assistant Professor, Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak 3Senior Professor, Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak 4Senior Resident, Department of Orthopedics, Pt. BD Sharma PGIMS, Rohtak 5Junior Resident, Department of Orthopaedics, Pt. B.D. Sharma PGIMS, Rohtak Abstract The authors discuss an interesting case of a Pacinian corpuscle neuroma in the fi nger of a young woman who presented with severe digital pain. The clinical signs were very prominent. The patient had complete pain relief following excision of the tumor. Pacinian corpuscle neuromas are rare, with only about few cases reported in the literature. The histology, presenting features and associated conditions are discussed in detail. In addition to a neuroma or glomus tumor, Pacinian corpuscle hyperplasia should be considered in the differential diagnosis of digital or palmar pain of unknown etiology. Introduction Neural tumours composed exclusively of Pacinian corpuscles or showing focal Pacinian differentiation are extremely rare and have only occasionally been reported in the literature. -
RET Controls Sympathetic Innervation
Development 128, 3963-3974 (2001) 3963 Printed in Great Britain © The Company of Biologists Limited 2001 DEV8811 RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons Hideki Enomoto1, Peter A. Crawford1, Alexander Gorodinsky1, Robert O. Heuckeroth2,3, Eugene M. Johnson, Jr3 and Jeffrey Milbrandt1,* 1Departments of Pathology and Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA 2Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8116, St Louis, MO 63110, USA 3Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8113, St Louis, MO 63110, USA *Author for correspondence (e-mail: [email protected]) Accepted 26 July 2001 SUMMARY Sympathetic axons use blood vessels as an intermediate trunks and accelerated cell death of sympathetic neurons path to reach their final target tissues. The initial contact later in development. Artemin is expressed in blood vessels between differentiating sympathetic neurons and blood during periods of early sympathetic differentiation, and vessels occurs following the primary sympathetic chain can promote and attract axonal growth of the sympathetic formation, where precursors of sympathetic neurons ganglion in vitro. This analysis identifies RET and artemin migrate and project axons along or toward blood vessels. as central regulators of early sympathetic innervation. We demonstrate -
Pacinian Corpuscle Tumor
International Journal of Medical and Health Research International Journal of Medical and Health Research ISSN: 2454-9142 Received: 10-08-2019; Accepted: 12-09-2019 www.medicalsciencejournal.com Volume 5; Issue 11; November 2019; Page No. 48-51 Pacinian corpuscle tumor Dr. Pathik Shah1, Dr. Hiten Kareliya2, Dr. Salome3, Dr. Tushar Toprani4 1 Department of Internal Medicine, Indian Oil Corporation limited, Vadodara, Gujarat, India 2 Consultant Infectious diseases, Prime Hospital, Vadodara, Gujarat, India 3 Senior Histopathologist, Toprani Lab, Vadodara, Gujarat, India 4 Senior Pathologist, Toprani Lab, Vadodara, Gujarat, India Abstract The authors discuss an interesting case of a Pacinian corpuscle neuroma in the finger of a young woman who presented with severe digital pain. The pain was initially attributed to pus collection in the interphalangeal joint of the thumb. The clinical signs were very subtle. The patient had complete pain relief following excision of the tumor. Pacinian corpuscle neuromas are rare, with only about few cases reported in the literature. The histology, presenting features and associated conditions are discussed in detail. In addition to a neuroma or glomus tumor, Pacinian corpuscle hyperplasia should be considered in the differential diagnosis of digital or palmar pain of unknown etiology. Keywords: Pacinian cell neuroma, Pacinian corpuscle neuroma, Painful hand lesions 1. Introduction Schematic diagram of the microscopic structure of a Pacinian corpuscles are mechanoreceptors found in human Pacinian corpuscle showing a single unmyelinated nerve and other animals. They are distributed in the dermis from fiber surrounded by connective tissue lamellae. The part of the fingers and palm of the hand, the conjunctiva, near the nerve outside the capsule is myelinated joints, in the mesenteries, branching blood vessels, penis, urethra, clitoris, parietal peritoneum and loose connective tissue. -
Fine Structure of Eimer's Organ in the Coast Mole (Scapanus Orarius)
THE ANATOMICAL RECORD 290:437–448 (2007) Fine Structure of Eimer’s Organ in the Coast Mole (Scapanus orarius) PAUL D. MARASCO,1 PAMELA R. TSURUDA,2 DIANA M. BAUTISTA,2 3 AND KENNETH C. CATANIA * 1Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee 2Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 3Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee ABSTRACT Eimer’s organ is a small, densely innervated sensory structure found on the glabrous rhinarium of most talpid moles. This structure consists of an epidermal papilla containing a central circular column of cells as- sociated with intraepidermal free nerve endings, Merkel cell neurite complexes, and lamellated corpuscles. The free nerve endings within the central cell column form a ring invested in the margins of the column, surrounding 1–2 fibers that pass through the center of the column. A group of small-diameter nociceptive free nerve endings that are immuno- reactive for substance P surrounds this central ring of larger-diameter free nerve endings. Transmission electron microscopy revealed a high concentration of tonofibrils in the epidermal cells of the central column, suggesting they are more rigid than the surrounding keratinocytes and may play a mechanical role in transducing stimuli to the different recep- tor terminals. The intraepidermal free nerve endings within the central column begin to degrade 15 mm from the base of the stratum corneum and do not appear to be active within the keratinized outer layer. The pe- ripheral free nerve endings are structurally distinct from their counter- parts in the central column and immunocytochemical double labeling with myelin basic protein and substance P indicates these afferents are unmyelinated. -
Mechanisms of Mechanotransduction in the Pacinian Corpuscle
1 Mechanisms of Mechanotransduction in the Pacinian Corpuscle Submitted by Svetlana Pitts-Yushchenko to the University of Exeter as a thesis for the degree of Doctor of Philosophy in Physics, July 2013 The thesis is available for Library use on the understanding that it is copyright material and that no quotation from the thesis may be published without proper acknowledgment. I certify that all material in this thesis which is not my own work has been identified and that no material has previously been submitted and approved for the award of a degree by this or any other University. (Signature) ………………………………………………………………… 2 3 Abstract Touch perception is important in most living organisms and extremely sensitive detection systems have evolved to meet this need. Pacinian corpuscles (PCs) are primary mechanoreceptors. In the human, they are found in the skin (where they act as touch receptors), in the joints, in muscles and in many organs (where they act as motion sensors). The purpose of the work described in this thesis is to investigate how the performance of the PC is achieved, with reference to structure, mechanical properties and possible transduction mechanisms. PCs were obtained from the equine hoof and their distribution and clustering were investigated. Corpuscles were located in the frog area of the hoof (the digital cushion); they were found to be surrounded by adipose tissue and often closely associated with blood vessels. The physiological implications of these observations are discussed. The structure and composition of corpuscles was investigated using confocal microscopy with histological stains for collagen, proteoglycans and lipids. Nonlinear microscopy was also used to investigate the distribution of collagen (by second- harmonic generation), elastin (by intrinsic two-photon fluorescence) and membrane 4 lipids (by coherent Raman imaging). -
Sensory Receptors A17 (1)
SENSORY RECEPTORS A17 (1) Sensory Receptors Last updated: April 20, 2019 Sensory receptors - transducers that convert various forms of energy in environment into action potentials in neurons. sensory receptors may be: a) neurons (distal tip of peripheral axon of sensory neuron) – e.g. in skin receptors. b) specialized cells (that release neurotransmitter and generate action potentials in neurons) – e.g. in complex sense organs (vision, hearing, equilibrium, taste). sensory receptor is often associated with nonneural cells that surround it, forming SENSE ORGAN. to stimulate receptor, stimulus must first pass through intervening tissues (stimulus accession). each receptor is adapted to respond to one particular form of energy at much lower threshold than other receptors respond to this form of energy. adequate (s. appropriate) stimulus - form of energy to which receptor is most sensitive; receptors also can respond to other energy forms, but at much higher thresholds (e.g. adequate stimulus for eye is light; eyeball rubbing will stimulate rods and cones to produce light sensation, but threshold is much higher than in skin pressure receptors). when information about stimulus reaches CNS, it produces: a) reflex response b) conscious sensation c) behavior alteration SENSORY MODALITIES Sensory Modality Receptor Sense Organ CONSCIOUS SENSATIONS Vision Rods & cones Eye Hearing Hair cells Ear (organ of Corti) Smell Olfactory neurons Olfactory mucous membrane Taste Taste receptor cells Taste bud Rotational acceleration Hair cells Ear (semicircular -
Growth Factors Acting Via Endothelial Cell-Specific Receptor Tyrosine Kinases: Vegfs, Angiopoietins, and Ephrins in Vascular Development
Downloaded from genesdev.cshlp.org on September 25, 2021 - Published by Cold Spring Harbor Laboratory Press REVIEW Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development Nicholas W. Gale1 and George D. Yancopoulos Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591-6707 USA The term ‘vasculogenesis’ refers to the earliest stages of since been shown to be a critical regulator of endothelial vascular development, during which vascular endotheli- cell development. Not surprisingly, the specificity of al cell precursors undergo differentiation, expansion, and VEGF-A for the vascular endothelium results from the coalescence to form a network of primitive tubules restricted distribution of VEGF-A receptors to these (Risau 1997). This initial lattice, consisting purely of en- cells. The need to regulate the multitude of cellular in- dothelial cells that have formed rather homogenously teractions involved during vascular development sug- sized interconnected vessels, has been referred to as the gested that VEGF-A might not be alone as an endothelial primary capillary plexus. The primary plexus is then re- cell-specific growth factor. Indeed, there has been a re- modeled by a process referred to as angiogenesis (Risau cent explosion in the number of growth factors that spe- 1997), which involves the sprouting, branching, and dif- cifically act on the vascular endothelium. This explosion ferential growth of blood vessels to form the more ma- involves the VEGF family, which now totals at least five ture appearing vascular patterns seen in the adult organ- members. In addition, an entirely unrelated family of ism. This latter phase of vascular development also in- growth factors, known as the Angiopoietins, recently has volves the sprouting and penetration of vessels into been identified as acting via endothelial cell-specific re- previously avascular regions of the embryo, and also the ceptors known as the Ties. -
Differential Expression of Neuregulin-1 Isoforms and Downregulation of Erbin Are Associated with Erb B2 Receptor Activation in Diabetic Peripheral Neuropathy
Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy By Pan Pan Submitted to the graduate degree program in Pharmacology and Toxicology and the Graduate Faculty of the University of Kansas in partial fulfillment of the requirements for the degree of Doctor of Philosophy. ______________________________ Rick T. Dobrowsky, Ph.D., Chairperson _______________________________ Jeff Staudinger, Ph.D. _______________________________ Alexander Moise, Ph.D. _______________________________ Honglian Shi. Ph.D. ________________________________ Brian Ackley, Ph.D. Date Defended: April 18th The Dissertation Committee for Pan Pan certifies that this is the approved version of the following dissertation: Differential expression of neuregulin-1 isoforms and downregulation of erbin are associated with Erb B2 receptor activation in diabetic peripheral neuropathy By Pan Pan _______________________________ Rick T. Dobrowsky, Ph.D., Chairperson th Date approved: April 18 ii Table of Contents Table of Contents ......................................................................................................................... iii Abstract ......................................................................................................................................... vi Acknowledgements ..................................................................................................................... vii List of Tables and Figures .......................................................................................................... -
A Theoretical and Experimental Investigation Into the Distribution, Morphology and Function of Pacinian Corpuscles
A theoretical and experimental investigation into the distribution, morphology and function of pacinian corpuscles. Submitted by Joanne Danielle Dale to the University of Exeter as a dissertation for Master of Philosophy in Physics, October 2014. This dissertation is available for Library use on the understanding that it is copyright material and that no quotation from the dissertation may be published without proper acknowledgement. I certify that all material in this dissertation which is not my own work has been identified and that no material has previously been submitted and approved for the award of a degree by this or any other University. (Signature) ……………………………………………………………………………… 1 Abstract The distribution, morphology and function of the pacinian corpuscle was examined. The distribution in rat feet was recorded using both Magnetic Resonance Imaging (MRI) and dissection. The mechanical properties of the corpuscle were investigated using a theoretical model based upon previous work by (Loewenstein & Skalak, 1966). The model was used to examine how the corpuscle’s structure affects its function in healthy and diseased states. Distribution data gathered by dissection revealed the majority of corpuscles were restricted to the adipose tissue of each foot pad. Densest concentrations were in the rear foot pads. The remainder were located in the digits and in close proximity of bone via the interosseous membrane and wrist ligaments. Localisation near capillaries was common. MRI was not invasive and detected a greater number of corpuscles but held limitations in its ability to separate corpuscles in close proximity. Dissection was invasive and showed a lower number of corpuscles but greater confidence could be contributed to the correct identification of each corpuscle. -
NT-3 and CNTF Exert Dose-Dependent, Pleiotropic Effects
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector Developmental Biology 297 (2006) 182–197 www.elsevier.com/locate/ydbio NT-3 and CNTF exert dose-dependent, pleiotropic effects on cells in the immature dorsal root ganglion: Neuregulin-mediated proliferation of progenitor cells and neuronal differentiation Sharon J. Hapner a, Katherine M. Nielsen a,b, Marta Chaverra a, Raymond M. Esper d, ⁎ Jeffrey A. Loeb c,d, Frances Lefcort a, a Department of Cell Biology and Neuroscience, Montana State University, Bozeman, MT 59717, USA b Science and Education Partnership, University of California, San Francisco, CA 94143, USA c Department of Neurology and Center for Molecular Medicine, Wayne State University, Detroit, MI 48201, USA d Genetics, Wayne State University, Detroit, MI 48201, USA Received for publication 3 May 2005; revised 1 May 2006; accepted 10 May 2006 Available online 19 May 2006 Abstract Neurons in the nascent dorsal root ganglia are born and differentiate in a complex cellular milieu composed of postmitotic neurons, and mitotically active glial and neural progenitor cells. Neurotrophic factors such as NT-3 are critically important for promoting the survival of postmitotic neurons in the DRG. However, the factors that regulate earlier events in the development of the DRG such as the mitogenesis of DRG progenitor cells and the differentiation of neurons are less defined. Here we demonstrate that both NT-3 and CNTF induce distinct dose-dependent responses on cells in the immature DRG: at low concentrations, they induce the proliferation of progenitor cells while at higher concentrations they promote neuronal differentiation.