Professor Michael Neuberger: Biochemist Behind Life-Saving
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Sequencing As a Way of Work
Edinburgh Research Explorer A new insight into Sanger’s development of sequencing Citation for published version: Garcia-Sancho, M 2010, 'A new insight into Sanger’s development of sequencing: From proteins to DNA, 1943-77', Journal of the History of Biology, vol. 43, no. 2, pp. 265-323. https://doi.org/10.1007/s10739-009- 9184-1 Digital Object Identifier (DOI): 10.1007/s10739-009-9184-1 Link: Link to publication record in Edinburgh Research Explorer Document Version: Peer reviewed version Published In: Journal of the History of Biology Publisher Rights Statement: © Garcia-Sancho, M. (2010). A new insight into Sanger’s development of sequencing: From proteins to DNA, 1943-77. Journal of the History of Biology, 43(2), 265-323. 10.1007/s10739-009-9184-1 General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact [email protected] providing details, and we will remove access to the work immediately and investigate your claim. Download date: 28. Sep. 2021 THIS IS AN ADVANCED DRAFT OF A PUBLISHED PAPER. REFERENCES AND QUOTATIONS SHOULD ALWAYS BE MADE TO THE PUBLISHED VERION, WHICH CAN BE FOUND AT: García-Sancho M. -
King's College, Cambridge
King’s College, Cambridge Annual Report 2014 Annual Report 2014 Contents The Provost 2 The Fellowship 5 Major Promotions, Appointments or Awards 18 Undergraduates at King’s 21 Graduates at King’s 26 Tutorial 36 Research 47 Library and Archives 51 Chapel 54 Choir 57 Bursary 62 Staff 65 Development 67 Appointments & Honours 72 Obituaries 77 Information for Non Resident Members 251 While this incremental work can be accomplished within the College’s The Provost maintenance budget, more major but highly desirable projects, like the refurbishment of the Gibbs staircases and the roof and services in Bodley’s will have to rely on support apart from that provided by the endowment. 2 I write this at the end of my first year at The new Tutorial team under Perveez Mody and Rosanna Omitowoju has 3 THE PROVOST King’s. I have now done everything once begun its work. There are now five personal Tutors as well as specialist and am about to attend Alumni Weekend Tutors, essentially reviving a system that was in place until a few years ago. reunion dinners for the second time. It has It is hoped that the new system will reduce the pastoral pressure on the been a most exciting learning experience THE PROVOST Directors of Studies, and provide more effective support for students. getting to know the College. While I have not had much time for my own research I In the Chapel we have said farewell to our Dean, Jeremy Morris. Jeremy have had the opportunity to learn about came to the College from Trinity Hall in 2010, and after only too short a others’ interests, and have been impressed time returns to his former College as its Master. -
Michael Neuberger Obituary | Science | Theguardian.Com
Michael Neuberger obituary | Science | theguardian.com http://www.theguardian.com/science/2013/dec/01/michael-ne... Search Michael Neuberger obituary Biochemist who discovered how antibodies are greatly improved KJ Patel theguardian.com, Sunday 1 December 2013 13.03 GMT Michael Neuberger developed mice that carried humanised antibody genes, with the aim of tricking the animal to produce humanised antibodies when confronted with specific targets. Photograph: MRC Laboratory of Molecular Biology The molecular biologist Michael Neuberger's research into antibodies did much to increase our understanding of how the body defends itself against microbes – single-cell organisms including viruses and bacteria. His own death at the age of 59 came, by sad coincidence, from myeloma, a cancer of the immune system leading to uncontrolled antibody production. When Neuberger was a PhD student at Imperial College London, his supervisor, Brian Hartley, suggested Neuberger visit the South African biologist Sydney Brenner at the MRC Laboratory of Molecular Biology (LMB) in Cambridge to collect some bacterial strains. Brenner spent several hours talking to Neuberger and the scale and scope of the discussion left his head spinning. As a consequence, Neuberger was drawn back to the LMB in 1980 and remained there for the rest of his career, eventually becoming its deputy director. 1 of 4 06/12/2013 12:46 Michael Neuberger obituary | Science | theguardian.com http://www.theguardian.com/science/2013/dec/01/michael-ne... But before that, Neuberger gained his PhD and on Brenner's advice spent two years in Cologne with Klaus Rajewsky. At the time Rajewsky was pioneering molecular techniques to understand the immune system. -
Pg62-64 Muir Obituary Junbio06
Obituary Obituaries Helen graduated in 1944 and labelled glycine (chemically synthe- stayed on at Oxford to do research sized by Helen), which was injected and a doctorate in the Department of into rabbits; this strategy led to Helen Chemistry. Her first work was on the investigating the labelling of collagen synthesis of antimalarial compounds from glycine, which helped establish Downloaded from http://portlandpress.com/biochemist/article-pdf/28/3/62/6153/bio028030062.pdf by guest on 08 February 2021 under the supervision of Dr F.E. the concept of metabolic pools and King and then with Professor Robert precursors of what were then, these Robinson on the chemical synthesis intractable components of connective of penicillin — it was during World tissues. She also formed friendships War II, and the supply of penicillin to here with others interested in colla- stop wound infection was a high pri- gen, including David Jackson, Robert ority. Unfortunately, the structure of Harkness and Dennis Lowther. penicillin was a source of contro- This began Helen’s interest in versy and the structure favoured by human connective tissues and she Professor Robinson’s team, on which was awarded an Empire Rheumatism Helen was asked to work, later Fellowship with research space at St turned out to be incorrect. However, Mary’s Medical School, London. She she received a sound grounding in found St Mary’s a shock environment organic synthesis in the Dyson after the well-equipped labs at Mill Helen Muir (1920–2005) Perrins Laboratory and she learnt Hill; however, she received strong much from others there at the time, support from the Professor of by Helen Muir had a remarkable life and including John Cornforth, Norman Medicine, Stanley Peart, and she used Tim Hardingham career. -
“Without Such Freedom There Would Have Been No Shakespeare
1 DEFENDING ACADEMIC FREEDOM SINCE 1933 “Without such freedom there would have been no Shakespeare no Goethe no Newton no Faraday no Pasteur and no Lister.” Albert Einstein Royal Albert Hall fundraiser 5th October 1933 80th Anniversary CARA Scholars at Risk UK Universities Network Contents 1933–2013 AIM To facilitate cooperation and collaboration between UK higher education institutions in support of refugee and threatened academics and in defence and HISTORY promotion of academic and university freedoms worldwide. AAC (1933-1936) Why CARA Origins Professor Shula Marks OBE FBA 4 A Close-knit Community Joseph Buckley 4 NEtwork UNIVERSITIES University of Aberdeen, Abertay University, Aston Academic Assistance Council University, University of Bath, Bath Spa University, University of Bedfordshire, Memories of Tess Simpson Professor Paul Broda 5 Birkbeck College, University of Birmingham, University of Bournemouth, SPSL (1936-1999) University of Brighton, University of Bristol, Brunel University, University of LEGACY: MUSIC, ART HISTORY, MEDICINE Buckingham, University of Cambridge, Canterbury Christ Church University, SPSL Rescue of Musicians from Nazi Europe 6 Incorporated as the Matters Cardiff University/Prifysgol Caerdydd, University of Central Lancashire, Central Professor David Josephson School of Speech and Drama, University of Chester, University of Chichester, City Annabel Stafford in conversation with: Sir Ralph Kohn FRS, 6 Society for the Protection of SINCE MAY 1933, when Hitler closed the universities same daily tasks of teaching and research. They can University, University College London, Courtauld Institute of Art, University of Professor Gustav Born FRS and Eva Loeffler OBE Science and Learning of Germany to Jews, the demands on CARA have never understand the internal debate when a Lecturer realises Cumbria, University of Dundee, University of Durham, University of East London, stopped. -
Fellowship, to the Crown
2013 TRINITY COLLEGE cambridge trinity college cambridge annual record annual record 2013 Trinity College Cambridge Annual Record 2012–2013 Trinity College Cambridge CB2 1TQ Telephone: 01223 338400 e-mail: [email protected] website: www.trin.cam.ac.uk Cover photo: Aldous Bertram Contents 5 Editorial 9 The Master’s Installation Dinner 10 Speech of Welcome by Professor David McKitterick 13 Reply by Sir Gregory Winter 17 Commemoration 18 Chapel Address 22 The Health of the College 24 The Master’s Response on behalf of the College 29 Alumni Relations and Development 30 The Office and the Annual Fund 32 Alumni Associations 42 Annual Gatherings C 43 Alumni Achievements ontent 47 Benefactions 65 College Activities S 67 First & Third Trinity Boat Club 71 Field Club 88 Students’ Union and Societies 107 College Choir 109 Features 110 Heading South: Michael Proctor 112 Magnificent Seven: Trinity Men and Mrs Thatcher 118 Building the Bouncing Bomb: the Dambusters Raid seventy years on TRINITY ANNUAL RECORD 2013 3 131 Fellows, Staff and Students 132 The Master and Fellows 144 Appointments and Distinctions 149 In Memoriam 158 College Notes 167 The Register 168 In Memoriam 172 Addresses Wanted 191 An Invitation to Donate S content TRINITY ANNUAL RECORD 2013 | 4 Editorial The first highlight of the year occurred as early as 2 October when Sir Gregory Winter was installed as Master, just in time for a photograph of the ceremony to appear in our last edition. There were no speeches on that occasion, but on 30 November a special dinner was held, in lieu of the Audit Feast, to celebrate the Master’s installation. -
Outputs, Outcomes and Impact of MRC Research: 2012 Report 10: Impacts on the Private Sector 10: Impacts on the Private Sector
Outputs, outcomes and impact of MRC research: 2012 report 10: Impacts on the private sector 10: Impacts on the private sector Impacts on the private sector Summary The MRC is interested in the contribution that its research has made to the formation and growth of spin out companies. It is hoped that MRC research will lead to discoveries that can be commercially exploited and result in positive economic impacts such as employment, provision of new goods and services, and direct investment into the UK. The formation of spin out companies is one route to this. It is important that the MRC can both describe its contribution in this area and understand better the processes leading to the successful formation of spin out companies. The MRC is not suggesting that the setting up of spin out companies per se is a measure of success. We are interested in the downstream impact realised, as a result of pursuing this route to commercialisation. The MRC has had a spectacular track record in this area. Cambridge Antibody Technology (CAT), formed in 1989, is still noted as the only academic spin out which has resulted in the discovery of a blockbuster treatment (Humira). CAT was acquired by AstraZeneca in 2006 for £702 million, at which time CAT employed more than 300 staff. An earlier route to commercialising MRC research was the formation of Celltech by the National Enterprise Board in 1980, which floated on the stock exchange in 1993 and was bought by the Belgian Pharmaceutical company UCB in 2004 for £1.53 billion. At that time, Celltech employed around 1,900 people, 450 of which worked in research and development. -
Pg62-64 Muir Obituary Junbio06
Obituary Obituaries Helen graduated in 1944 and labelled glycine (chemically synthe- stayed on at Oxford to do research sized by Helen), which was injected and a doctorate in the Department of into rabbits; this strategy led to Helen Chemistry. Her first work was on the investigating the labelling of collagen synthesis of antimalarial compounds from glycine, which helped establish Downloaded from http://portlandpress.com/biochemist/article-pdf/28/3/62/6153/bio028030062.pdf by guest on 02 October 2021 under the supervision of Dr F.E. the concept of metabolic pools and King and then with Professor Robert precursors of what were then, these Robinson on the chemical synthesis intractable components of connective of penicillin — it was during World tissues. She also formed friendships War II, and the supply of penicillin to here with others interested in colla- stop wound infection was a high pri- gen, including David Jackson, Robert ority. Unfortunately, the structure of Harkness and Dennis Lowther. penicillin was a source of contro- This began Helen’s interest in versy and the structure favoured by human connective tissues and she Professor Robinson’s team, on which was awarded an Empire Rheumatism Helen was asked to work, later Fellowship with research space at St turned out to be incorrect. However, Mary’s Medical School, London. She she received a sound grounding in found St Mary’s a shock environment organic synthesis in the Dyson after the well-equipped labs at Mill Helen Muir (1920–2005) Perrins Laboratory and she learnt Hill; however, she received strong much from others there at the time, support from the Professor of by Helen Muir had a remarkable life and including John Cornforth, Norman Medicine, Stanley Peart, and she used Tim Hardingham career. -
The History of Biochemistry
ISSN 2409-4943. Ukr. Biochem. J., 2021, Vol. 93, N 2 THES HHISI TORY OF BBIOCHEMISIOCHEMISTRY UDC 577.213.3 doi: https://doi.org/10.15407/ubj93.02.116 DOUBLE NOBEL PRIZE WINNER: FREDERICK SANGER – THE FATHER OF GENOMICS T. V. DANYLOVA1, S. V. KOMISARENKO2 1National University of Life and Environmental Sciences of Ukraine, Kyiv; e-mail: [email protected], 2Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv; e-mail:[email protected] Received: 02 February 2021; Accepted: 23 April 2021 This paper aims to outline briefly the main stages of Frederick Sanger’s scientific activity – the only person to have won two Nobel Prizes in Chemistry (1958, 1980). His work on the structure of proteins, es- pecially that of insulin, and the determination of base sequences in nucleic acids made an immense impact on the development of biochemistry and especially on the development of a new scientific field – molecular biology. His methods for determining the primary structure of proteins and nucleic acids helped biochemists and molecular biologists to determine the structure of many proteins and nucleic acids and laid the basis for genetic engineering. K e y w o r d s: Frederick Sanger, Nobel Prize, insulin, proteins, nucleic acids, Sanger’s method of DNA se- quencing. he Nobel Prize is considered the highest England).Hewasthemiddlechildinthefamilyof honorinthescientificcommunity.Reflecting Frederick Sanger, a country medical doctor, and his T the highest achievements one can attain in wifeCicelySanger(néeCrewdson),thedaughterof socie ty, it has become more than just a prize – it a wealthy cotton manufacturer. -
A Tribute to Michael S. Neuberger
A tribute to Michael S. Neuberger Patricia J. Gearhart, Garnett Kelsoe J Clin Invest. 2014;124(1):3-5. https://doi.org/10.1172/JCI74366. Obituary Michael S. Neuberger, whose contributions to the field of molecular biology of B lymphocytes paved the way for humanizing therapeutic antibodies and understanding the genetic mechanisms of antibody expression, affinity maturation, and class switching, died October 26th, 2013, of multiple myeloma, at the age of 59 (Figure 1). Michael Neuberger was the youngest of four sons of the distinguished biochemist, Albert Neuberger, and his artist wife, Lilian. Albert Neuberger left Germany in 1933, as the Nazis came to power, and settled in London where he became a professor of chemical pathology. Remarkably, Fred Sanger, Albert Neuberger’s distinguished student, was the mentor of Cesar Milstein, who in turn, started Michael Neuberger along his own career. Neuberger studied biochemistry at the University of Cambridge and began his scientific career with Brian Hartley at Imperial College London, working on the evolution of enzymes in bacteria. His doctoral work earned him a research fellowship from Trinity College, Cambridge, where he sought out Milstein’s help to enter the new field of molecular immunology. Milstein offered him a position in the Medical Research Council Laboratory of Molecular Biology (LMB) but sent him first to the laboratory of Klaus Rajewsky in Cologne to “learn immunology.” After working in Germany for two years on immunoglobulin class-switched antibody pairs, Neuberger returned to the LMB where he began to study […] Find the latest version: https://jci.me/74366/pdf Obituary A tribute to Michael S.