toxins Article Coagulotoxicity of Bothrops (Lancehead Pit-Vipers) Venoms from Brazil: Differential Biochemistry and Antivenom Efficacy Resulting from Prey-Driven Venom Variation Leijiane F. Sousa 1,2, Christina N. Zdenek 2 , James S. Dobson 2, Bianca op den Brouw 2 , Francisco Coimbra 2, Amber Gillett 3, Tiago H. M. Del-Rei 1, Hipócrates de M. Chalkidis 4, Sávio Sant’Anna 5, Marisa M. Teixeira-da-Rocha 5, Kathleen Grego 5, Silvia R. Travaglia Cardoso 6 , Ana M. Moura da Silva 1 and Bryan G. Fry 2,* 1 Laboratório de Imunopatologia, Instituto Butantan, São Paulo 05503-900, Brazil;
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[email protected] (A.M.M.d.S.) 2 Venom Evolution Lab, School of Biological Sciences, University of Queensland, St. Lucia, QLD 4072, Australia;
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[email protected] (F.C.) 3 Fauna Vet Wildlife Consultancy, Glass House Mountains, QLD 4518, Australia;
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[email protected] (K.G.) 6 Museu Biológico, Insituto Butantan, São Paulo 05503-900, Brazil;
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[email protected] Received: 18 September 2018; Accepted: 8 October 2018; Published: 11 October 2018 Abstract: Lancehead pit-vipers (Bothrops genus) are an extremely diverse and medically important group responsible for the greatest number of snakebite envenomations and deaths in South America.