We cannot guarantee course . . No refunds will be made thereafter. AMA PRA Category 1Credit(s) 4.5 Please note that space is limited, so register early! register so limited, is that space note Please materials on site to anyone registering later than September 6, 2013.

Office of Continuing Medical Education 5323 Harry Hines Blvd. / Dallas, Texas 75390-9059

Not printed or mailed at State expense Dallas, Texas Dallas, COURSE DIRECTOR James Willson, James Willson, M.D. Director, Harold C. Simmons Harold C. Director, Comprehensive Cancer Center UT Southwestern Medical Center

southwestern.edu/Reves

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4 e s l l A $50 handling fee will be deducted from cancellation refunds. Refund requests must be received by mail or fax prior to September 13, 2013 In 1990, a donation of $2 million was made to endow the Wendy and Emery Reves Reves and Emery made to endow the Wendy of $2 million was In 1990, a donation Cancer Symposium and to establish the Reves Breast International Breast Cancer University Hospitals and Clinics in honor Center at UT Southwestern Diagnostic and Treatment and Mrs. Emery Reves. of Mr. model before runway became a leading New York Reves, a native of Marshall, Texas, Wendy in 1945 while he was Hungarian author and publisher, meeting Emery Reves, a distinguished Press, Reves had established the -based Cooperation In 1930 Emery living in New York. in France, the news service. They lived in the Villa the first international syndicated it with items While restoring the home, they began furnishing former home of . $35 million. travels, including a collection of art valued at more than acquired on their extensive Reves’ death. the in 1985, five years after Mr. The collection was given to the National Arts Philanthropy, for received the Komen Award Mrs. Reves, who died in 2007, (Dallas), and was an Silver Cup Award and the TACA for Philanthropy (New York), Club Award Churchill Society. honorary trustee of the International professionals, research scientists and This course is designed for physicians and medical postdoctoral and clinical fellows, graduate students and other interested individuals. faculty, participants should be able to link the educational objectives Upon completion of this live activity, to Core Competencies and: • critical aspects of the latest research as it relates to understanding Describe • which focus on the unique aspects of breast the important research areas Recognize • cancer. emerging areas of translational research related to breast Identify Southwestern Medical Center is accredited by the Accreditation The University of Texas provide continuing medical education Council for Continuing Medical Education (ACCME) to for physicians. Southwestern Medical Center designates this live activity for a maximum The University of Texas of P a i r e t the extent of their participation in the activity. in CME activities should be made aware of policy that participants It is UT Southwestern’s presentation(s). Each speaker any affiliation or financial interest that may affect the speaker’s The faculty members’ relationships has completed and signed a conflict of interest statement. will be disclosed in the course syllabus. Because this course is meant to educate physicians with what is currently in use and what may be available in the future, there may be “off-label” use discussed in the presentations. Speakers have been requested to inform the audience when off-label use is being discussed. The registration fee entitles the participant admission to the conference, all course materials, continental breakfast, lunch and refreshment breaks during the meeting. a maximum capacity of the T. Boone Pickens Auditorium, all additional registrants thereafter will maximum capacity of the T. be provided a seat in the adjacent multi-purpose room where an audio and video feed will be set up. are unable to process any Enrollment is confirmed upon receipt of registration fee. We registration without payment. Please register early. m

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Office of Continuing Medical Education 5323 Harry Hines Blvd. / Dallas, Texas 75390-9059

Not printed or mailed at State expense Wendy and Emery Reves International Breast Cancer Symposium Register on-line at utsouthwestern.edu/Reves

Dallas Love Field Location UT Southwestern Medical Center T. Boone Pickens Biomedical Cedar Springs Maple Avenue Research Building (NG3.112) Registration and Breakfast 6001 Forest Park Road

Dallas, Texas 75390 .

Parking Visitor Parking is available in the parking garage entered from 6001 Forest Park, located adjacent to the T. Boone Pickens Biomedical Building. The garage entrance is to the Session 1: Microenvironment/Metabolism right of the front building entrance. The garage elevators will take you to the third floor. Signs will be posted to assist you.

**Please note: Due to new UTSW parking regulations, all UTSW faculty and staff must park in their designated parking areas as indicated by their parking permit. Anyone not in compliance will be ticketed by UTSW security. Please utilize campus shuttle services or nearby city public parking areas as applicable. Indicate Credit Desired:

Additional For additional information, please call The Office of Continuing Medical Education, Registration Fees: $100 Non-UT Southwestern Physicians Information 214-648-3138, 1-800-688-8678, or email [email protected]. Complimentary – Nurses Complimentary – UT Southwestern Faculty, Fellows, Residents, and Staff The Office of Continuing Medical Education reserves the right to limit registration and cancel courses, no less than one week prior to the course, should circumstances make this necessary. Method of Payment: MASTERCARD VISA Program We accommodate people with disabilities. Please call 214-648-3138 for more Break Accessibility information, or mark the space indicated on the registration form. To ensure accommodation, please register as soon as possible. Session 2: Biomarkers/Precision Therapeutics The University of Texas Southwestern Medical Center is committed to providing programs and activities to all persons regardless of race, color, national origin, religion, sex, age, veteran status, or disability.

UT Southwestern Medical Center is an equal opportunity institution. AMERICAN EXPRESS Lunch – Roundtable Discussions with Speakers COURSE DIRECTOR James Willson, M.D. Director Harold C. Simmons Comprehensive Cancer Center UT Southwestern Medical Center Dallas, Texas GUEST FACULTY UT SOUTHWESTERN FACULTY Matt Ellis, B.Sc., M.B., B.Chir., Ph.D., FRCP Joyce O’Shaughnessy, M.D. Agnes Witkiewicz, M.D. Professor of Medicine Co-Chair, Breast Cancer Research Associate Professor Session 3: Early Clinical Translation Anheuser-Bush Endowed Chair of Medical Oncology Associate Medical Director, US Oncology Research Department of Pathology Director, Breast Cancer Program Baylor-Charles A. Sammons Cancer Center CHECK: Washington University School of Medicine Texas Oncology and The US Oncology Network Erik Knudsen, Ph.D. St. Louis, Missouri Celebrating Women Endowed Chair in Professor of Pathology Breast Cancer Research Charles T. Ashworth Chair of Pathology Suzanne Fuqua, Ph.D. Baylor University Medical Center Department of Pathology Professor Dallas, Texas Depts. of Medicine and Molecular Cell Biology Ralph J. DeBerardinis, M.D., Ph.D. Lester and Sue Smith Breast Center Jennifer Pietenpol, Ph.D. Associate Professor Baylor College of Medicine Director Children’s Medical Center Research Institute Houston, Texas Vanderbilt-Ingram Comprehensive Cancer Center B.F. Byrd Jr. Professor of Molecular Oncology David Euhus, M.D. Senthil Muthuswamy, Ph.D. Professor of Biochemestry, Cancer Biology and Professor Senior Scientist Otolaryngology Department of Surgery Refund Policy Lee K. and Margaret Lau Chair in Vanderbilt University Breast Cancer Research Nashville, Tennessee Gray Pearson, M.D. Adjourn . No refunds will be made thereafter. Ontario Cancer Institute Assistant Professor Princess Margaret Cancer Centre, UHN Thea Tlsty, Ph.D. Simmons Comprehensive Cancer Center Campbell Family Institute for Breast Cancer Research Professor ADA Statement Professor, Depts of Medical Biophysics and Cell and Department of Pathology System Biology University of California, San Francisco University of Toronto San Francisco, California Toronto, Ontario Wendy and Emery Reves International REGISTRATION FORM September 20, 2013 #RP1309D Breast Cancer Register on-line at utsouthwestern.edu/Reves Symposium

UT Southwestern Medical Center Name T. Boone Pickens Biomedical Address Research Building (NG3.112) Registration and Breakfast 6001 Forest Park Road City State Zip Code Dallas, Texas 75390 Last Four Digits of SS# ❏ UT Southwestern Alumni Business Phone Fax Degree Specialty Session 1: Microenvironment/Metabolism Email Address: Please indicate preferred method to receive registration confirmation: ❏ Email ❏ Fax ❏ Mail ❏ Check here to receive our free monthly email calendar of upcoming CME activities. **Please note: Due to new UTSW parking regulations, all UTSW faculty and staff must park in their designated parking areas as indicated by their parking permit. Anyone not in compliance will be ticketed by UTSW security. ™ Please utilize campus shuttle services or nearby city public parking areas as applicable. Indicate Credit Desired: ❏ AMA PRA Category 1 ❏ General

Registration Fees: ❏ $100 Non-UT Southwestern Physicians ❏ Complimentary – Nurses ❏ Complimentary – UT Southwestern Faculty, Fellows, Residents, and Staff

Method of Payment: Break ❏ MASTERCARD ❏ VISA Security Code CARD # Session 2: Biomarkers/Precision Therapeutics Exp. Date Signature of Cardholder Print Cardholder’s Name

Billing Address of Cardholder:

City State Zip Code

❏ AMERICAN EXPRESS Security Code Lunch – Roundtable Discussions with Speakers CARD #

Exp. Date Signature of Cardholder

Print Cardholder’s Name

Billing Address of Cardholder: Session 3: Early Clinical Translation City State Zip Code

❏ CHECK: UT Southwestern/CME If paying by check make checks payable to: Fax completed registration form to 214/648-4804. Mail completed registration form to: UT Southwestern Medical Center 5323 Harry Hines Blvd. / Dallas, Texas 75390-9059

❏ Dietary Restrictions:

Refund Policy A $25 handling fee will be deducted from cancellation refunds. Refund requests must be received by mail or fax prior to Adjourn September 13, 2013. No refunds will be made thereafter. ADA Statement ❏ Please check this box if you require assistance because of a disability to make this program accessible to you. Someone from our office will be in touch with you. Wendy and Emery Reves International Breast Cancer Symposium Register on-line at utsouthwestern.edu/Reves SYMPOSIUM AGENDA - Friday, September 20, 2013 UT Southwestern Medical Center T. Boone Pickens Biomedical AM Research Building (NG3.112) 7:30 Registration and Breakfast 6001 Forest Park Road AM Dallas, Texas 75390 8:30 Welcome James Willson, M.D. 8:35 AM Breast Cancer in Translation: Using Knowledge of Disease to Direct Patient Care Erik Knudsen, Ph.D.

Session 1: Microenvironment/Metabolism 9:05 AM New Culprits Behind Breast Cancer Progression Agnes Witkiewicz, M.D. **Please note: Due to new UTSW parking regulations, all UTSW faculty and staff must park in their designated parking areas as indicated by their parking permit. Anyone not in compliance will be ticketed by UTSW security. 9:15 AM Cell Polarity Proteins and Tumor Initiation and Progression Indicate Credit Desired: Please utilize campus shuttle services or nearby city public parking areas as applicable. Senthil Muthuswamy, Ph.D. 9:45 AM Phenotypic Plasticity and Implications for Tumor Heterogeneity and Therapy Registration Fees: $100 Non-UT Southwestern Physicians Thea Tlsty, Ph.D. Complimentary – Nurses Complimentary – UT Southwestern Faculty, Fellows, Residents, and Staff 10:15 AM Cancer Metabolism: Basic Biology and Translational Opportunities Ralph DeBerardinis, M.D., Ph.D. Method of Payment: MASTERCARD VISA 10:45 AM Break

Session 2: Biomarkers/Precision Therapeutics 11:00 AM Molecular Regulation of Breast Cancer Invasion Gray Pearson, Ph.D. 11:10 AM Novel Mechanisms of Hormone Resistance in Breast Cancer Suzanne Fuqua, Ph.D. AMERICAN EXPRESS 11:30 AM Lunch – Roundtable Discussions with Speakers 1:00 PM Deciphering the Heterogeneity of Triple Negative Breast Cancer: Subtypes, Targets and Therapeutic Approaches Jennifer Pietenpol, Ph.D.

Session 3: Early Clinical Translation 1:30 PM From Bench to Bedside: Targeting the Unique Biology of CHECK: Hyperglycemia-Associated Breast Cancer David Euhus, M.D. 1:40 PM Breast Cancer Genomics – Insights from DNA and RNA Sequencing Matt Ellis, B.Sc., M.B., B.Chir., Ph.D., F.R.C.P. 2:10 PM Breast Cancer Subtypes: Phenotype to Genotype Joyce O’Shaughnessy, M.D. Refund Policy 2:40 PM Adjourn . No refunds will be made thereafter. ADA Statement We cannot guarantee course . No refundsNomade will thereafter. be . AMA PRA Category 1Credit(s) 4.5 Please note that space is limited, so register early! register so limited, is that space note Please materials on site to anyone registering later than September 6, 2013.

Wendy and Emery Reves InternationalBreast Cancer Symposium

Office of Continuing Medical Education 5323 Harry Hines Blvd. / Dallas, Texas 75390-9059

Not pr inted o r mail ed at S tate ex pense

SEPTEMBER 2013

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Register on-line at utsouthwestern.edu/Reves