Hypertrophic Olivary Degeneration Concomitant with Bilateral Middle
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The Cerebellum in Sagittal Plane-Anatomic-MR Correlation: 2
667 The Cerebellum in Sagittal Plane-Anatomic-MR Correlation: 2. The Cerebellar Hemispheres Gary A. Press 1 Thin (5-mm) sagittal high-field (1 .5-T) MR images of the cerebellar hemispheres James Murakami2 display (1) the superior, middle, and inferior cerebellar peduncles; (2) the primary white Eric Courchesne2 matter branches to the hemispheric lobules including the central, anterior, and posterior Dean P. Berthoty1 quadrangular, superior and inferior semilunar, gracile, biventer, tonsil, and flocculus; Marjorie Grafe3 and (3) several finer secondary white-matter branches to individual folia within the lobules. Surface features of the hemispheres including the deeper fissures (e.g., hori Clayton A. Wiley3 1 zontal, posterolateral, inferior posterior, and inferior anterior) and shallower sulci are John R. Hesselink best delineated on T1-weighted (short TRfshort TE) and T2-weighted (long TR/Iong TE) sequences, which provide greatest contrast between CSF and parenchyma. Correlation of MR studies of three brain specimens and 11 normal volunteers with microtome sections of the anatomic specimens provides criteria for identifying confidently these structures on routine clinical MR. MR should be useful in identifying, localizing, and quantifying cerebellar disease in patients with clinical deficits. The major anatomic structures of the cerebellar vermis are described in a companion article [1). This communication discusses the topographic relationships of the cerebellar hemispheres as seen in the sagittal plane and correlates microtome sections with MR images. Materials, Subjects, and Methods The preparation of the anatomic specimens, MR equipment, specimen and normal volunteer scanning protocols, methods of identifying specific anatomic structures, and system of This article appears in the JulyI August 1989 issue of AJNR and the October 1989 issue of anatomic nomenclature are described in our companion article [1]. -
Bilateral Cerebellar Dysfunctions in a Unilateral Meso-Diencephalic Lesion
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.44.4.361 on 1 April 1981. Downloaded from Journal of Neurology, Neurosurgery, and Psychiatry, 1981, 44, 361-363 Short report Bilateral cerebellar dysfunctions in a unilateral meso-diencephalic lesion D VON CRAMON From the Max-Planck-Institute for Psychiatry, Munich, Germany SUMMARY The clinical syndrome of a 65-year-old patient with a slit-shaped right-sided meso- diencephalic lesion was analysed. A cerebellar syndrome with limb-kinetic ataxia, intention tremor and hypotonicity in all extremities as well as ataxic dysarthria was found. The disruption of the two cerebello-(rubro)-thalamic pathways probably explained the signs of bilateral cere- bellar dysfunction. The uncrossed ascending limb of the right, and the crossed one of the left brachium conjunctivum may have been damaged by the unilateral lesion extending between caudal midbrain and dorsal thalamus. Protected by copyright. Most of the fibres which constitute the superior general hospital where neurological examination cerebellar peduncle leave the cerebellum and showed bilateral miosis, convergent strabism, vertical originate in cells of the dentate nucleus but also gaze paresis on upward gaze with gaze-paretic nystag- arise from neurons of the globose and emboli- mus, flaccid sensori-motor hemiparesis with increased stretch reflexes and Babinski sign on the left side, forme nuclei. The crossed ascending fibres of the and dysmetric movements of the right upper extremity. brachia conjunctiva constitute the major outflow The CT scan showed an acute haemorrhage in the from the cerebellum, they form the cerebello- right mesodiencephalic area. On 19 February 1979 (rubro)-thalamic and dentato-thalamic tracts.' the patient was admitted to our department. -
Anatomy of Cerebellum Rajasekhar Sajja Srinivasa Siva Naga
Chapter Anatomy of Cerebellum Rajasekhar Sajja Srinivasa Siva Naga Abstract The cerebellum receives inputs from spinal cord, cerebrum, brainstem, and sensory systems of the body and controls the motor system of the body. The Cerebellum harmonizes the voluntary motor activities such as maintenance of posture and equilibrium, and coordination of voluntary muscular activity including learning of the motor behaviours. Cerebellum occupies posterior cranial fossa, and it is relatively a small part of the brain. It weighs about one tenth of the total brain. Cerebellar lesions do not cause motor or cognitive impairment. However, they cause slowing of movements, tremors, lack of equilibrium/balance. Complex motor action becomes shaky and faltering. Keywords: Cerebellum, Spinocerebellar ataxia, Cortex, Medulla, Peduncles, Nuclei 1. Introduction The Cerebellum is the largest part of the hindbrain and develops from the alar plates (rhombic lips) of the metencephalon. It lies between the temporal and occipital lobes of cerebrum and the brainstem in the posterior cranial fossa. It is attached to the posterior surface of the brainstem by three large white fibre bundles. It is attached to the midbrain by superior cerebel- lar peduncle, pons by middle cerebellar peduncle, and medulla by inferior cerebellar peduncle. Cerebellum is concerned with three primary functions: a) coordination of voluntary motor functions of the body initiated by the cerebral cortex at an uncon- scious level, b) maintenance of balance, and posture, c) Maintenance of muscle tone. It receives and integrates the sensory inputs from the cerebrum and the spinal cord necessary for a planning and smooth coordination of the movements [1]. Cerebellar lesions result in irregular and uncoordinated, awkward intentional muscle movements. -
Cerebellum and Inferior Olive
Cerebellum and Inferior Olivary Nucleus Spinocerebellum • Somatotopically organised (vermis controls axial musculature; intermediate hemisphere controls limb musculature) • Control of body musculature • Inputs… Vermis receives somatosensory information (mainly from the trunk) via the spinocerebellar tracts and from the spinal nucleus of V. It receives a direct projection from the primary sensory neurons of the vestibular labyrinth, and also visual and auditory input from brain stem nuclei. • Intermediate hemisphere receives somatosensory information (mainly from the limbs) via the spinocerebellar tracts (the dorsal spinocerebellar tract, from Clarke’s nucleus of the lower limb, and the cuneocerebellar tract, from the accessory cu- neate nucleus of the upper limb, carry information from muscle spindle afferents; both enter via the ipsilateral inferior cerebellar peduncle). • An internal feedback signal arrives via the ventral spinocerebellar tract (lower limb) and rostral spinocerebellar tract (upper limb). (Ventral s.t. decussates in the spinal cord and enters via the superior cerebellar peduncle, but some fibres re-cross in the cerebellum; rostral s.t. is an ipsilateral pathway and enters via sup. & inf. cerebellar peduncles.) • Outputs to fastigial nucleus, which projects to the medial descending systems: (1) reticulospinal tract [? n. reticularis teg- menti pontis and prepositus hypoglossi?]; (2) vestibulospinal tract [lateral and descending vestibular nn.]; and (3) an as- cending projection to VL thalamus [Å cells of origin of the ventral corticospinal tract]; (4) reticular grey of the midbrain [=periaqueductal?]; (5) inferior olive [medial accessory, MAO]. • … and interposed nuclei, which project to the lateral descending systems: (1) magnocellular portion of red nucleus [Å ru- brospinal tract]; (2) VL thalamus [Å motor cx which gives rise to lateral corticospinal tract]; (3) reticular nucleus of the pontine tegmentum; (4) inferior olive [dorsal accessory, DAO]; (5) spinal cord intermediate grey. -
Calcification of the Corpus Striatum and Dentate Nuclei Occurring in a Family by J
J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.14.4.253 on 1 November 1951. Downloaded from J. Neurol. Neurosurg. Pgchiat., 1951, 14, 253. CALCIFICATION OF THE CORPUS STRIATUM AND DENTATE NUCLEI OCCURRING IN A FAMILY BY J. FOLEY Fronm the Neurological Department, St. George's Hospital, London Dense symmetrical calcification of the corpus no previous illnesses of note, and on direct questioning striatum is rare, but of some general interest for there was no history of tetany or thyroid disorder. two reasons. First, in a significant number of the There was no family history of mental disturbance, reported cases this apparently degenerative condi- epilepsy, or endocrine abnormality. The patient had had seven children. The first died in convulsion at three tion is closely linked with a metabolic disorder, months, but the remaining six are well. Four years hypoparathyroidism, which may be idiopathic, before admission it was noticed that the patient was parathyroprivic, or of the variety in which the becoming slower in her movements, and that her memory parathyroid glands are histologically normal but was failing. At about the same time she began to have guest. Protected by copyright. the body is unable to respond to parathormone brief attacks of vertigo, in one of which she fell forwards, (Albright's pseudohypoparathyroidism). Secondly, cutting her head and leg; none of these attacks was in no other degenerative disease limited to a neuro- associated with loss of consciousness. One year before physiological system can the process be visualized admission her gait became unsteady, and after a further radiologically. In contrast with the rare gross eight months her legs were so weak and unsteady that under she was unable to climb stairs without assistance. -
Anatomy of Cerebellum & Relevant Connections
Anatomy of Cerebellum & Relevant Connections Neuroanatomy block-Anatomy-Lecture 14 Editing file Objectives At the end of the lecture, students should be able to: ● Describe the external features of the cerebellum (lobes, fissures). ● Describe briefly the internal structure of the cerebellum. ● List the name of cerebellar nuclei. ● Relate the anatomical to the functional subdivisions of the cerebellum. ● Describe the important connections of each subdivision. ● Describe briefly the main effects in case of lesion of the cerebellum. Color guide ● Only in boys slides in Green ● Only in girls slides in Purple ● important in Red ● Notes in Grey The Cerebellum Origin : from hindbrain,lies behind Pons & Medulla Separated from them by Fourth ventricle. Connection To Brain Stem : by inferior, middle & superior cerebellar peduncles. External Features: It consists of two cerebellar hemispheres joined in midline by the vermis Its surface is highly convoluted forming folia separated by fissures. Anatomical Subdivision Posterior (middle) lobe: Flocculonodular lobe : Anterior lobe: in front behind primary fissure in front of secondary of primary fissure on (Between Primary & (Posterolateral) the superior surface. Secondary fissures fissure on the inferior = posterolateral) surface . 3 Constituents Internal Structure and Nuclei of Cerebellum Inner white matter: cerebellar medulla. Afferent Fibres: (4 afferent fibers) Deeply seated nuclei in ● Outer grey matter: Climbing fibres: (direct to purkinje cells). from inferior olivary nucleus, relay to purkinje cells white matter: ● cerebellar cortex Mossy fibres: (indirect to purkinje cells) rest of fibres: from medial to lateral: Divided into 3 layers: 1. From vestibular nuclei 2. From spinal cord 3. From pons 1. Fastigial: smallest one 1. Outer molecular layer They relay to granule cells which in turn relay to purkinje cells and most medial Finally all afferent fibres passing through the medulla relay to purkinje cells in the cortex. -
Zonal Organization of the Flocculovestibular Nucleus Projection in the Rabbit: a Combined Axonal Tracing and Acetylcholinesterase Histochemicalstudy
THE JOURNAL OF COMPARATIVE NEUROLOGY 354k51-71 (1995) Zonal Organization of the Flocculovestibular Nucleus Projection in the Rabbit: A Combined Axonal Tracing and Acetylcholinesterase HistochemicalStudy J. TAN, A.H. EPEMA, AND J. VOOGD Department of Anatomy, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands (J.T., J.V.) and Department of Anesthesiology, Academic Hospital, University of Groningen, Groningen, The Netherlands (A.H.E.) ABSTRACT With the use of retrograde transport of horseradish peroxidase we confirmed the observation of Yamamoto and Shimoyama ([ 19771 Neurosci Lett. 5279-283) that Purkinje cells of the rabbit flocculus projecting to the medial vestibular nucleus are located in two discrete zones, FZIl and FZlv, that alternate with two other Purkinje cell zones, FZI and FZIII, projecting to the superior vestibular nucleus. The retrogradely labeled axons of these Purkinje cells collect in four bundles that occupy the corresponding floccular white matter compart- ments, FC1-4,that can be delineated with acetylcholinesterase histochemistry (Tan et al. [ 1995al J. Comp. Neurol., this issue). Anterograde tracing from small injections of wheat germ agglutin-hoseradish peroxidase in single Purkinje cell zones of the flocculus showed that Purkinje cell axons of FZrr travel in FC2to terminate in the medial vestibular nucleus. Purkinje cell axons from FZI and FZIII occupy the FCI and FC3 compartments, respectively, and terminate in the superior vestibular nucleus. Purkinje cell axons from all three compartments pass through the floccular peduncle and dorsal group y. In addition, some fibers from FZI and FZIJ,but not from FZIII, arch through the cerebellar nuclei to join the floccular peduncle more medially. -
Widespread Inhibitory Projections from the Interposed Cerebellar Nucleus 2 3 Elena N
bioRxiv preprint doi: https://doi.org/10.1101/2020.12.31.425011; this version posted January 1, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. 1 Widespread inhibitory projections from the interposed cerebellar nucleus 2 3 Elena N. Judd1, Samantha M. Lewis1, Daniel G. Heck1, Abigail L. Person1 4 5 1. Department of Physiology and Biophysics, University of Colorado School of 6 Medicine, Anschutz Medical Campus 7 8 Contact: <[email protected]> 9 10 Abstract 11 12 The cerebellum consists of parallel parasagittal modules that contribute to diverse behaviors, 13 spanning motor to cognitive. Recent work illustrating a role for the anterior interposed nucleus 14 (IntA) in reach control in mice raised questions of its anatomical organization that could confer 15 functional specificity. We employed intersectional cell- and projection- specific labeling 16 methods to map IntA inputs and outputs. In contrast to long-standing dogma 17 of primarily excitatory outputs and restricted inferior olive targeting inhibitory output, we found 18 that inhibitory IntA neurons ramified widely within the brainstem, targeting both motor- and 19 sensory-related nuclei, suggesting potential functional roles in disinhibitory control or predictive 20 sensory cancellation. Using monosynaptic rabies tracing, we then found that excitatory output 21 neurons receive fewer and more precisely organized inputs than inhibitory neurons, which may 22 set them up for distinct computations. Together these data suggest IntA contains at least two 23 distinct output circuits and promise advances in identifying parallel computations of the 24 cerebellum. -
Cerebellum(Small Brain)
Cerebellum (Small brain) • Posterior part of hind brain • In adult it weighs around150 gm • Situated in posterior cranial fossa behind the pons &medulla separated from them by fourth ventricle • From the cerebrum it is separated by tentorium cerebelli Subdivisions Cerebellum consist of a part lying near the midline called the vermis & two lateral hemisphere •Two surfaces superior inferior •On superior surface there is no distinction between vermis & hemisphere •On inferior surface vermis lies in depth of vallecula •Vermis is separated from corresponding hemisphere by paramedian surface • Surface of cerebellum is marked by parallel running fissures • They divide the surface into narrow Folia • Section of the cerebellum cut at right angle to the folia axis has the appearance of tree so given the name of Arbor vitae • Some of the fissures are deep. They divide the cerebellum into lobes which is constituted by smaller lobules • Like cerbrum it also has a superficial layer of grey matter the cerebellar cortex • Because numerous fissures are present the actual cerebellar cortex is much more then what is seen on surface • Cerebellar notches Anterior Posterior Fissures- primary fissure Horizontal fissure posterolateral fissure Lobes- anterior lobe Middle lobe Posterior lobe • Functional areas of cerebellar cortex Vermis- Movement of the long axis of the body namely neck, shoulders, thorax, abdomen & hips • Paravermal areas- control the muscles of distal pert of the limbs especially the hands & feet • Lateral zone is concerned with the planning of sequential movements of the entire body & is involved with the conscious assessment of movement errors Morphological & functional divisions – Archicerebellum- flocculonodular lobe & lingula Oldest part. -
Anatomical Evidence for the Involvement of Medial Cerebellar Output from the Interpositus Nuclei in Cognitive Functions
Anatomical evidence for the involvement of medial cerebellar output from the interpositus nuclei in cognitive functions Xiaofeng Lua,b,c,d,1, Shigehiro Miyachia,e, and Masahiko Takadaa,f aDepartment of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183-8526, Japan; bBrain Sciences Center, Veterans Administration Medical Center, Minneapolis, MN 55417; cDepartment of Neurology, School of Medicine, University of Minnesota, Minneapolis, MN 55414; dDepartment of Neurophysiology, School of Medicine, Juntendo University, Tokyo 113-8421, Japan; and eCognitive Neuroscience Section and fSystems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Aichi 484-8506, Japan Edited* by Richard F. Thompson, University of Southern California, Los Angeles, CA, and approved October 4, 2012 (received for review June 29, 2012) Although the cerebellar interpositus nuclei are known to be involved 3 mm rostral to the caudal end of the sulcus (Fig. 1 A and B). The in cognitive functions, such as associative motor learning, no ana- forelimb region of the M1 was identified by means of intracortical tomical evidence has been available for this issue. Here we used microstimulation (Fig. 1 A and C). With the 3-d postinjection pe- retrograde transneuronal transport of rabies virus to identify neurons riod, these cortical injections retrogradely labeled many neurons in in the cerebellar nuclei that project via the thalamus to area 46 of the the cerebellar nuclei as the second-order neuron labeling via the prefrontal cortex of macaques in comparison with the projections to thalamus (Fig. 2). Most of the labeled neurons were found on the the primary motor cortex (M1). -
The Rationale for the Dentate Nucleus As a Target for Deep Brain Stimulation in Dystono-Dyskinetic Syndromes
Review Article Annals of Neurological Surgery Published: 08 Nov, 2019 The Rationale for the Dentate Nucleus as a Target for Deep Brain Stimulation in Dystono-Dyskinetic Syndromes Claire L Nicholson1,6, Philippe Coubes1,2,3,4,5* and Gaetan Poulen1,2,3,4,5 1Department of Neurosurgery, University Hospital of Montpellier, France 2Department of Neurosurgery, Institute of Functional Genomics, France 3Department of Neurosurgery, French National Center for Scientific Research, France 4Department of Neurosurgery, National Institute for Health and Medical Research, France 5Department of Neurosurgery, University Montpellier I, France 6Department of Neurosurgery, Newcastle General Hospital, UK Abstract Purpose: To discuss the potential of Deep Brain Stimulation (DBS) of the dentate nucleus as a treatment for dystono-dyskinetic syndromes. Methods: An extensive literature review has been carried out, covering the anatomy and physiology of the dentate nucleus and the experimental evidence for its involvement in the pathophysiology of dystonia and dyskinesia. Results: Evidence from animal models and from functional imaging in humans is strongly in favor of involvement of the dentate nucleus in dystono-dyskinetic syndromes. Results of previous surgical series of dentate nucleus stimulation have been promising but precise descriptions of the movement disorders being treated are lacking and outcome measures have generally not been well defined. Conclusion: In the light of new evidence regarding the involvement of the dentate nucleus in OPEN ACCESS dystono-dyskinetic -
The Cerebellum
Institute of Anatomy, 2nd and 1st Medical Faculty R. Druga MOZEČEK Anatomický ústav 2.a 1. LF R. Druga „Little brain „ Cerebellar gyri = folia Cortex, subcortical white matter, nuclei, Kůra, bílá hmota, jádra Excessive folding of the cerebellar surface (cortex) Mimořádně bohatá gyrifikace kůry Little brain Located in the posterior crerebral fossa Connected with the brain stem- by peduncles (inferior, middle, superior) Is covered by the cerebellar cortex (3 layers). Cortex is extensively folded (folia-oriented mediolaterally) White matter fibers going to and coming from the cortex In the white matter are the cerebellar nuclei MR examination Fossa cranii posterior Posterior cranial fossa Arterial supply SCA AICA PICA Weigert Staining Myelinizovaná vlákna White matter has a treelike appearance = arbor vitae ( „tree of life „) Klüver - Barrera staining Folia are not interupted Cerebellar hemispheres Folia jsou nepřerušena and vermis Unfolded surface of the cerebellum Rozvinutá kůra do plochy (dvourozměrná rekonstrukce) Breadth = 10 – 15 cm Šířka = 10 – 15 cm Délka = 1 mm Anterior lobe (I – V lobules) Posterior lobe (VI – IX lobules) Flocculo-nodular lobe (lobule X) Deep Fissures Fissury VII B – boundary between superior and inferior surface Cerebellar Longitudinal zones – lobes and a) Vermis (worm) b) Paravermal zone Lobuli c) Lateral portion I – X Lobi a Lobuli I - X CEREBELLAR NUCLEI, neurons glutamatergic, excitatory, high spontaneous activity Mozečková jádra, glutamátergní neurony, vysoká spontánní aktivita J.E. Purkyně 1837 Purkyně observed for the first time large cells of the Wroclaw, Poland cerebellar cortex Breslau, Silesia Purkyně ´s original lithography (engraving) R. y Cajal : Histologie du systeme nerveux, 1911. Santiago Ramon y Cajal 1911 (Cajal confirmed Purkyně´s findings) Basket cells, inhibitory interneurons, GABAergic Kompletní dendritická arborizace Purkyňovy b.