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AMERICAN ACADEMY OF PEDIATRICS Section on Ophthalmology AMERICAN ASSOCIATION FOR PEDIATRIC OPHTHALMOLOGY AND STRABISMUS AMERICAN ACADEMY OF OPHTHALMOLOGY Screening Examination of Premature Infants for Retinopathy of Prematurity ABSTRACT. This statement revises a previous state- tion published thus far, the sponsoring organizations ment on screening of premature infants for retinopathy of this statement suggest the following guidelines for of prematurity originally published in 1997. the United States: 1. Infants with a birth weight of less than 1500 g or ABBREVIATION. ROP, retinopathy of prematurity. with a gestational age of 28 weeks or less, as well as selected infants between 1500 and 2000 g with INTRODUCTION an unstable clinical course who are believed to be etinopathy of prematurity (ROP) is a retinal at high risk by their attending pediatrician or neo- disorder of low birth weight premature in- natologist, should have at least 2 fundus exami- Rfants potentially leading to blindness in a nations performed after pupillary dilation using small but significant percentage of those infants. The binocular indirect ophthalmoscopy to detect ROP. results of the Multicenter Trial of Cryotherapy for One examination is sufficient only if it unequivo- Retinopathy of Prematurity Cooperative Group indi- cally shows the retina to be fully vascularized cated that treatment is associated with a 41% de- bilaterally. crease in the occurrence of posterior retinal traction 2. Examination for ROP should be performed by an folds or detachments and a 19% to 24% decrease in ophthalmologist with sufficient regular experi- the incidence of blindness when evaluated 5 years 1–3 ence and knowledge in the examination of pre- later. Because of the sequential nature of the pro- term infants for ROP to identify the location and gression of ROP, the proven benefits of cryotherapy sequential retinal changes in this disorder using and, more recently, the acceptance of at least equiv- binocular indirect ophthalmoscopy. The location alent therapeutic benefit of laser therapy for the same 4–7 and sequential retinal changes, if any, should be indications, standards of practice now demand recorded using the International Classification of carefully timed retinal examinations of at-risk infants Retinopathy of Prematurity.8 by an ophthalmologist experienced in the examina- 3. The first examination should normally be per- tion of preterm infants for ROP to minimize the risk formed between 4 and 6 weeks of chronologic of visual loss by those infants. (postnatal) age or, alternatively, within the 31st to This statement outlines the principles on which a 33rd week of postconceptional or postmenstrual screening program to detect ROP in infants at risk age (gestational age at birth plus chronologic age), might be based. The goal of an effective screening whichever is later, as determined by the infant’s program must be to identify the relatively few pre- attending pediatrician or neonatologist. If using term infants who require treatment for ROP from the postconceptional age guideline, examinations among the much larger number born each year while are generally not needed in the first 4 weeks after minimizing the number of stressful examinations re- birth. The timing of the initial screening examina- quired for these sick infants. Any screening program tion may be adjusted appropriately on the basis of designed to implement an evolving standard of care other reliable data, such as local incidence and has inherent defects, such as overreferral or under- onset of ROP or the presence of other recognized referral, and cannot, by its very nature, duplicate the risk factors.8,9 The initial screening examination precision and rigor of a scientifically based clinical and subsequent examinations should be timed to trial. With that in mind and on the basis of informa- permit sufficient time for treatment, including, any extra time required for transfer to another facility for treatment, if necessary. Treatment The recommendations in this statement do not indicate an exclusive course should generally be accomplished within 72 hours of treatment or serve as a standard of medical care. Variations, taking into account individual circumstances, may be appropriate. of determination of the presence of threshold 1 PEDIATRICS (ISSN 0031 4005). Copyright © 2001 by the American Acad- ROP to minimize the risk of retinal detachment emy of Pediatrics. before treatment. Downloaded from www.aappublications.org/news by guestPEDIATRICS on September Vol. 26, 1082021 No. 3 September 2001 809 4. Scheduling of follow-up examinations at the rec- this difficulty in distinguishing between stages 2 ommendation of the examining ophthalmologist and 3 in posterior regions, infants with suspected is best determined by the findings at the first stage 3 ROP in zone I or border zone I to II with examination using the International Classification of plus disease should be examined especially care- Retinopathy of Prematurity. For example, if the ret- fully to determine if they meet the threshold cri- inal vasculature is immature and extends into teria noted above. zone II but no retinopathy is present, follow-up 7. Parents of infants with ROP should be informed examination should be planned at approximately of the nature and possible consequences of this 2- to 3-week intervals until normal vascularization disorder throughout the infant’s hospital stay, be- proceeds to zone III (ie, in the nasal periphery, ginning at the time of first diagnosis and continu- there is no retinopathy and normal vessels are ing on an ongoing basis with updates on its pro- present within 1 disk diameter of the ora serrata). gression during hospitalization. 5. Once an infant has been determined on first ex- 8. Responsibility for examination and follow-up of amination to be at risk for ROP, the following infants at risk for ROP must be carefully defined schedule is suggested: by each neonatal intensive care unit. Unit-specific A. Infants with ROP that may soon progress to criteria for examination for ROP should be estab- threshold ROP should be examined at least lished for each neonatal intensive care unit by weekly. These include: consultation and agreement between neonatology 1. Any infant with ROP less than threshold in and ophthalmology services. These criteria should zone I be recorded and should automatically trigger 2. Infants with ROP in zone II, including: scheduled ophthalmology examinations. If hospi- a) those with stage 3 ROP without plus tal discharge or transfer to another neonatal unit disease (defined as posterior pole dila- or hospital is contemplated before retinal matura- tion and tortuosity of the retinal vessels); tion into zone III has taken place, the availability b) those with stage 2 ROP with plus dis- of appropriate follow-up ophthalmologic exami- ease; and nation must be ensured, and specific arrangement c) those with stage 3 ROP with plus disease for that examination must be made before such not yet extensive enough to justify abla- discharge or transfer occurs. The transferring pri- tive surgery. mary physician should have the responsibility of B. Infants with less severe ROP in zone II should communicating orally and in writing what eye be examined at 2-week intervals. Those with- examinations are needed and their required tim- out ROP but with incomplete vascularization ing to the infant’s new primary physician. The in zone I should be seen at 1- to 2-week inter- new primary physician should ascertain the cur- vals until retinal vascularization has reached rent ocular examination status of the infant from zone III or until threshold conditions are the record and through communication with the reached. transferring physician so that any necessary ex- C. If the retinal vascularization is incomplete in aminations by an ophthalmologist with regular zone II but no ROP is detected, follow-up ex- experience and knowledge of the examination amination should be planned at approxi- of preterm infants for ROP can be arranged mately 2- to 3-week intervals until vasculariza- promptly at the receiving facility. If responsibility tion proceeds into zone III. for arranging follow-up after discharge is dele- D. Retinas with incomplete vascularization only gated to the parents, it must be clearly understood in zone III usually mature completely; ROP in by the parents that blindness is a possible out- zone III normally regresses (involutes) without come, that there is a critical time window to adverse consequences. However, the finding be met if treatment is to be successful, and that of normal vascularization in zone III is un- timely follow-up examination is essential to suc- usual in the initial examination of very low cessful treatment; this information should be gestational age infants. In cases in which zone transmitted to the parents orally and in writing. If III vascular maturation seems to be present on such arrangements for follow-up after transfer or initial examination of very low birth weight discharge cannot be made, the infant should not infants, this finding should be verified by at be transferred or discharged. least 1 repeat examination within 2 to 3 weeks. 6. Infants reaching threshold 1 disease (stage 3 ROP These recommendations replace the previous in zone I or II in 5 or more continuous clock hours American Academy of Pediatrics statement on or 8 cumulative clock hours [30° sectors] with plus ROP,10 are evolving, and may be modified as addi- disease [posterior retinal vessel dilation and tor- tional ROP risk factors, treatment, and long-term tuosity]) should receive ablative therapy for at outcomes are known. least 1 eye within 72 hours of diagnosis, generally before the onset of retinal detachment. Stage 3 Retinopathy of Prematurity Subcommittee, 1997–2001 ROP with vascularization in zone I or borderline Walter M. Fierson, MD, Chairperson zone I to II may appear different from purely zone Earl A. Palmer, MD II stage 3 disease in that proliferation may appear Robert A. Petersen, MD flat, only appearing to be significantly elevated Dale L.