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Department of Biotechnology Ministry of Science & Technology Government of India Annual Report 2018-2019 “Attaining new heights in biotechnology research, shaping biotechnology into a premier precision tool of the future for creation of wealth and ensuring social justice – specially for the welfare of the poor” Composition of the Committee for compilation of Annual Report 2018-19 1. Dr. Alka Sharma, Scientist G – Chairperson 2. Dr. Sandhya Shenoy, Scientist E – Member 3. Dr. Sangita Kasure, Scientist E – Member 4. Dr. Manoj Singh Rohilla, Scientist E – Member 5. Dr. Onkar Nath Tiwari, Scientist E – Member 6. Dr. Padma Singh, Scientist D – Member 7. Shri Mahesh Kumar AD(OL) – Member 8. Shri. J. K. Dora, US(A) – Member 9. Dr. Nitin Kumar Jain, Scientist E – Member Secretary ANNUAL REPORT 2018 - 19 Department of Biotechnology Ministry of Science & Technology Government of India DEPARTMENT OF BIOTECHNOLOGY 1 ANNUAL REPORT 2018-19 2 DEPARTMENT OF BIOTECHNOLOGY Contents 111 OVERVIEW 555 222 BUILDING CAPAAACITIES : HUMAN RESOURCE DEVELOPMENT, TRAININGS AND WORKSHOPS 12 333 RESEARCH & DEVELOPMENT, DEMONSTRATION AND TRANSLATION ACTIVITIES 32 - AGRICULTURE AND ALLIED AREAS 33 - BIOENERGY, BIORESOURCES AND ENVIRONMENT 555111 - HEALTHCARE AND MEDICAL BIOTECHNOLOGY 67 - KNOWLEDGE GENERATION, DISCOVERY RESEARCH, NEW TOOLS AND TECHNOLOGIES 92 444 BUILDING A VIBRANT ECOSYYYSSSTEM : CONNECTING UNIVERSITY RESEARCH AND INDUSTRYYY 103 - RESEARCH RESOURCES, SERVICE FACILITIES AND PLATFORMS 104 - BIO-TECHNOLOGY SCIENCE CLUSTERS 111000777 555 PROMOTING ENTREPRENUERSHIP AND INDUSTRIAL GROWTH 110 - MAKE IN INDIA 111 - START-UP INDIA 112 - BIODESIGN PROGRAMME 113 - BIOTECHNOLOGY PARKS & INCUBATORS PARKS 116 666 BUILDING INTERNATIONAL COLLABORATIONS AND PARTNERSHIPS 120 777 SPECIAL PROGRAMMES 126 - PROMOTING WOMEN SCIENTISTS - SCIENCE FOR WOMEN - WOMEN FOR SCIENCE 12777 - PROGRAMMES OF SOCIETAL RELEVANCE - RURAL AND SC/ST POPULATION 128 888 PROMOTING BIOTECHNOLOGY IN NORTH EASTERN REGION 132 999 AAAUTONOMOUS INSTITUTIONS AND PUBLIC SECTOR UNDERTTTAKINGS 111444111 10 REGULATION, INTELLECTUAL PROPERTTTY AND LEGISLATIONS 11178 11 ADMINSTRATION AND FINANCE 111888111 ABBREVIATIONS 111888777 DEPARTMENT OF BIOTECHNOLOGY 3 ANNUAL REPORT 2018-19 4 DEPARTMENT OF BIOTECHNOLOGY 01 OVERVIEW DEPARTMENT OF BIOTECHNOLOGY 5 ANNUAL REPORT 2018-19 The Department of Biotechnology (DBT), Ministry of Science Building Capacities - Human Resource Development, and Technology has laid emphasis on promotion of Trainings, Workshops excellence and innovation for discovery, early and late stage Building a skilled workforce is the key for strong, sustainable translational research in the areas of agriculture, affordable and balanced growth of the biotechnology sector. This year, healthcare & medical technology, food & nutritional security, DBT has implemented 15 new skill development courses for animal biotechnology, environmental safety, clean energy & Post Graduate Certificate/Diploma with an objective to bio-fuel, bio-manufacturing, etc. Innovation driven research provide high quality hands on training in tools and techniques in biotechnology and modern biology is being facilitated and in Medical Biotechnology, Agricultural Biotechnology and supported by the Department through its various schemes Computational Biology. With an aim to create specialized across the country. Building capacity in cutting edge areas of training programs for professionals, "The Bharat Boston research, developing right kind of infrastructure, building new Bioscience Beginning (B4) - Phase II" was launched with a national and international partnerships, development of provision for 16 postdoctoral students to undergo training in products and their commercialization for a robust bio- Harvard University for two years. 100 young students will economy and establishment of India as a world-class bio- also be trained in emerging technologies under this program. manufacturing hub for developing and developed markets Ten years of Joint partnership of DBT-India Wellcome Trust are the major thrust of the Department. Alliance was also recently celebrated. To infuse momentum in the growth of biotechnology sector Apart from the new programmes, 15 Scientists were selected in the country, DBT has formulated the National Biotechnology this year for National Bioscience Award for Career Development Strategy in consultation with the stakeholders Development; 9 scientists were awarded Innovative Young including scientists, educators, policy makers, leaders of Biotechnologist Award; 2 scientists were supported for industry and civil society, voluntary and non-governmental National Women Bio-scientist (Senior, Junior) Award for organisations, regulators and international experts. The Biotech Product, Process Development and strategy emphasizes the need for building a skilled workforce Commercialization; 2 outstanding scientists were awarded and leadership through specialized training programs for Distinguished Biotechnology Research Professorship Award professionals to facilitate technology competence, creating and 75 scientists were selected for the Ramalingaswami re- new career options for students aimed at motivating young entry fellowship. Under finishing school program for skill minds towards biotechnology, arranging faculty improvement enhancement of biotechnology students, 89 students were program for continuous improvement and attracting skills supported. for imbibing scientists and post docs. Establishing core facilities and instrumentation, creating specialized centres Human Resource Development in and around existing institutes, strengthening core capacities in the existing institutes and also establish new 72 PG Programmes Supported theme based institutes, data centres and repositories are 116 Star Colleges supported also the key components of this strategy. This also includes 2006 Scientists supported enhancement of research opportunities to provide sustained 695 Institutions supported support to basic sciences, promote multi-disciplinary research 15 Skill Certificate Diploma Courses supported in biology, attract non-biologists to address biological questions; encourage emerging technologies and foster global Fellowships and Trainings Supported (National) & national alliances. The focus is also on nurturing innovation & entrepreneurship to embed translational capacity in all major 942 JRF research centres and institutes, provide support for business 160 RA 1200 Teachers trained incubation, technology validation and scale-up infrastructure; 20 Bioinformatics National Certificate promote public-private partnership and setting up of 521 BITP Trainees bioclusters. 9 IYBA 6 DEPARTMENT OF BIOTECHNOLOGY OVERVIEW Research and Development, Demonstration and immunization programme & major strides towards vaccine Translational activities for diseases like malaria & dengue. Vaccine for falciparum malaria is under toxicology assessment (JAIVAC 2) and Agriculture and Allied Areas: Application of vaccine for vivax malaria has completed phase I trial biotechnological tools and techniques in agriculture and allied (JAIVAC1). areas including livestock and fisheries has led to various new developments this year. New Wheat variety Unnat A comprehensive program for prevention and control of sickle PBW343, resistant to leaf rust and stripe rust was developed cell anemia and thalassemia has also been initiated in by the scientists at PAU, Ludhiana through marker assisted phased manner starting with four districts of Odisha, namely backcross breeding approach. This variety is an improved Khorda, Sambalpur, Balasore and Koraput (Aspirational version of mega variety PBW343. Two bacterial blight district). A comprehensive study in India titled "Dementia resistant Basmati rice varieties Pusa Basmati 1728 and Science Programme: Incidence/ Prevalence/ Risk/ Pusa Basmati 1718 were developed and subsequently Intervention analysis of dementia and basic research thereof" released by Central Variety Release Committee after testing. was launched with an aim to provide reliable data regarding Of these, Pusa Basmati 1728 is a replacement of Pusa incidence, prevalence, biomarkers and risk and protective Basmati 1401 and Pusa Basmati 1718 is replacement of factors associated with the pathology of dementia. Pusa Basmati 1121, which are together grown on almost Devices, Implants, Make-in-India, Start-up India, 1.40 million ha. area currently. This year also saw the Bioincubators (in collaboration with BIRAC): In order establishment of DBT-PGGF "Plant Genotyping and Genomics to promote Startup India initiative, the Department alongwith Facility" (PGGF) anchored at NIPGR, New Delhi in PPP mode. BIRAC has launched various schemes and programmes. This national facility is a "single-window service system" for BIRAC has supported additional 4 new Bio-incubators during advanced genomics technology services that could positively 2018 through BioNEST scheme. As per one of the influence the Indian Seed industry. recommendations of the inter-ministerial meetings at NITI Bioenergy, Bioresource & Environment: The DBT-ICT Aayog, DBT has set up a facilitation cell (FIRST HUB) with the Centre for Energy Biosciences at Mumbai has announced a Secretariat at BIRAC to address the queries of the start-ups new project on Next Generation Waste Treatment Technology and innovators by the representatives of CDCSO, NIB, DBT, Platform, comprising three novel technologies. A 1MLD BIRAC, etc. With an aim to promote Make in India, BIRAC & capacity sewage water processing plant