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Atlas Journal Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Atlas Journal Atlas Journal versus Atlas Database: the accumulation of the issues of the Journal constitutes the body of the Database/Text-Book. TABLE OF CONTENTS Volume 11, Number 2, Apr-Jun 2007 Previous Issue / Next Issue Genes BOK (BCL2-related ovarian killer) (2q37.3). Alexander G Yakovlev. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 119-123. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/BOKID824ch2q37.html BIRC6 (Baculoviral IAP repeat-containing 6) (2p22). Christian Pohl, Stefan Jentsch. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 124-129. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/BIRC6ID798ch2p22.html AKAP12 (A kinase (PRKA) anchor protein 1) (6q25). Irwin H Gelman. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 130-136. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/AKAP12ID607ch6q25.html TRIM 24 (tripartite motif-containing 24) (7q34). Jean Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 137-141. [Full Text] [PDF] Atlas Genet Cytogenet Oncol Haematol 2007; 2 - I - URL : http://AtlasGeneticsOncology.org/Genes/TRIM24ID504ch7q34.html RUNX 2 (Runt-related transcription factor 2) (6p21). Athanasios G Papavassiliou, Panos Ziros. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 142-147. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/RUNX2ID42183ch6p21.html PTPRG (protein tyrosine phosphatase, receptor type, G) (3p14.2). Cornelis P Tensen, Remco van Doorn. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 148-152. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PTPRGID41930ch3p21.html PPP1R13L (protein phosphatase 1, regulatory (inhibitor) subunit 13 like) (19q13.32). Ulla Vogel. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 153-157. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/PPP1R13LID42997ch19q13.html MDM2 (transformed mouse 3T3 cell double minute 2, p53 binding protein) (12q15). Wenrui Duan, Miguel A Villalona-Calero. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 158-164. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/MDM2ID115ch12q15.html LYL1 (lymphoblastic leukemia derived sequence 1) (19p13.2). Yuesheng Meng, Mark D Minden. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 165-170. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/LYL1ID51ch19p13.html FHIT (Fragile Histidine Triad) (3p14.2). Teresa Druck, Kay Huebner. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 171-178. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/FHITID192ch3p14.html ERCC1 (excision repair complementing defective repair in Chinese hamster.) (19q13.32). Ulla Vogel. Atlas Genet Cytogenet Oncol Haematol 2007; 2 - II - Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 179-186. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/ERCC1ID40481ch19q13.html CASP-9 (caspase 9, apoptosis-related cysteine peptidase) (1p36.2). Sabrina Di Bartolomeo, Francesco Cecconi. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 187-193. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/CASP9ID423ch1p36.html AATF (Apoptosis Antagonizing Transcription Factor) (17q12). Deepak Kaul, Amit Khanna. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 194-198. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/AATFID534ch17q11.html STK11 (serine/threonine kinase 11) (19p13.3). Bharati Bapat, Sheron Perera. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 199-205. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/STK11ID292.html RTN4 (reticulon 4) (2p16.3). Masuo Yutsudo. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 206-213. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/RTN4ID42182ch2p16.html RHOA (ras homolog gene family, member A) (3p21.31). Teresa Gomez del Pulgar, Juan Carlos Lacal. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 214-222. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/RHOAID42107ch3p21.html RARRES1 (retinoic acid receptor responder (tazarotene induced) 1) (3q25.32). Kwok-Wai Lo, Grace TY Chung. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 223-229. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/RARRES1ID42050ch3q25.html DDX43 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 43) (6q13). Atlas Genet Cytogenet Oncol Haematol 2007; 2 - III - Etienne De Plaen. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 230-233. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/DDX43ID40288ch6q13.html CDK4 (cyclin-dependent kinase 4) (12q14). Anders Molven. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 234-238. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/CDK4ID238ch12q14.html AXIN2 (axin 2) (17q24.1). Thomas A Hughes. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 239-247. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Genes/AXIN2ID456ch17q24.html Leukaemias t(2;12)(q31;p13). Jean-Loup Huret. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 248. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t0212q31p13ID1459.html t(12;17)(p11;q11) in acute myeloid leukemia. David Betts. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 249-250. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/t1217p11q11ID1437.html Solid Tumours Cancer Prone Diseases Stiff-person syndrome. Franco Folli, Claudia Sommer. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 251-256. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/StiffpersonID10103.html Perlman syndrome (renal hamartomas, nephroblastomatosis and fetal gigantism). Atlas Genet Cytogenet Oncol Haematol 2007; 2 - IV - Maria Piccione, Giovanni Corsello. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 257-263. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/PerlmanID10117.html Pallister Hall Syndrome (PHS). Jennifer J Johnston, Leslie G Biesecker. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 264-267. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Kprones/PallisterHallID10126.html Deep Insights Genetic Instability in Cancer. Sheron Perera, Bharati Bapat. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 268-278. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Deep/GenetInstabilityCancerID20056.html Case Reports Reciprocal translocation t(2;12)(q31;p13) in a case of CMML. Despina Iakovaki, Markos Fisfis, Katy Stefanoudaki, Georgia Bardi. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 279-280. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/0212IakovakiID100017.html t(8;13)(p12;q12) in an atypical chronic myeloid leukaemia case. Valeria AS De Melo, Alistair G Reid. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 281-282. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/0813ReidID100018.html A case of myeloproliferative disorder with t(5;10)(q33;q21.2). Valeria AS De Melo, Alistair G Reid. Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 283-284. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/0510ReidID100019.html A novel chromosomal translocation (6;14)(p22;q32) in a case of precursor B-cell Acute Lymphoblastic Leukemia. Siddharth G Adhvaryu, Alka Dwivedi, Peggy Stoll. Atlas Genet Cytogenet Oncol Haematol 2007; 2 - V - Atlas Genet Cytogenet Oncol Haematol 2007; 11 (2): 285-288. [Full Text] [PDF] URL : http://AtlasGeneticsOncology.org/Anomalies/0614AdhvaryuID100020.html Educational Items © Atlas of Genetics and Cytogenetics in Oncology and Haematology X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA Home Genes Leukemias Solid Tumours Cancer-Prone Deep Insight Portal Teaching For comments and suggestions or contributions, please contact us [email protected]. Atlas Genet Cytogenet Oncol Haematol 2007; 2 - VI - Atlas of Genetics and Cytogenetics in Oncology and Haematology BOK (BCL2-related ovarian killer) Identity Other names Mtd (Matador) BOKL BCL2-like 9 BCL2L9 MGC4631 Hugo BOK Location 2q37.3 Local_order LOC728248 STK25 BOK THAP4 ATG4B DNA/RNA Description The gene encompasses 15,361 bp of DNA with 5 exons. Transcription Alternative splicing results in expression of two mRNA variants. The full-length (Bok-L) mRNA comprises 2.6 kb with the 639 bp open reading frame. The truncated form (Bok-S) results from skipping of exon three and a deletion of 43 bp in the Bok-L coding region. It has been shown that transcription activity of the Bok gene depends on expression of p53 and can be directly regulated at the gene promoter level by E2F transcription factors during cell cycle progression. Protein Description A Bok transcript was initially isolated from a rat ovarian fusion cDNA library. Sequencing of this transcript has revealed that full-length BOK protein consists of 213 amino acids and contains three conserved BCL2 homology regions BH1, BH2, and BH3 in addition to a C-terminal transmembrane domain. BOK-S that results from the alternative splicing has its N-terminal BH3 domain part fused to the C-terminal part of the BH1 region. Using the yeast two-hybrid system, it has been demonstrated that, although the BH domains composition of BOK-L protein was similar to that of BAX and BAK, it interacted only with MCL-1, BHRF1, and BCL2A1/BFL-1 but not other anti- apoptotic multidomain BCL-2 family members. Expression
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