RESEARCH REPORT 2007-2008 DIVISION OF HEALTH SCIENCES

(NZ) 0800 80 80 98 | www.otago.ac.nz | txt 866 | [email protected] research report 2OO7-2OO8 DIVISION OF HEALTH SCIENCES

Cover photo: Professor Mark Richards of the Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago, Christchurch. Professor Richards was the recipient of the 2008 University of Otago’s Distinguished Research Medal, and the Royal Society of New Zealand’s 2008 Sir Charles Hercus Medal for excellence in biomedical and health sciences.

Division of HEALTH SCIENCES 1 FROM THE PRO VICE-CHANCELLOR

It is a great pleasure to present this report of the research activities of the Division of Health Sciences for 2007-2008. The Division of Health Sciences at the University of Otago is a research intensive Division, and the past two years have been yet another exciting period of high activity and growth.

Researchers within the Division continue to be very successful in securing research funding in what is becoming an increasingly competitive environment. Our researchers attracted over $120 million of external funding in 2007 and 2008: the annual research income within the Division has doubled in the last 5 years. Major grants during 2007 and 2008 were awarded for projects aimed at preventing and treating conditions that affect the lives of many New Zealanders including heart disease, cancer, mental health disorders, diabetes, obesity, neurodegenerative disorders and other chronic conditions. Health inequalities research also attracted substantial funding.

Our researchers continue to publish extensively, with many articles appearing in the world’s most prestigious journals. The Division is also particularly encouraged by the increasing number of students attracted into its postgraduate programs. This trend not only reflects the high quality of the postgraduate programs we offer but also the excellent international reputations of our top researchers and teachers. A number of these were honoured with prestigious awards during 2007-2008 in recognition of their outstanding research contributions.

We are very pleased that we are able to continually attract so many high-calibre researchers to the University, and to further secure our reputation as an internationally recognised centre of excellence. As an example, during the past two years, the University of Otago’s Leading Thinkers initiative has established four more new high profile research positions within the Division.

The Division is proud to host a number of world-renowned research groups and centres. Examples are the Cancer Genetics Laboratory, the Centre for Neuroendocrinology, the Christchurch Cardioendocrine Research Group, the Virus Research Unit, the Injury Prevention Research Unit (IPRU), He Kainga Oranga – the Housing and Health Research Programme, and the Dunedin Multidisciplinary Health and Development Research Unit (DMHDRU).

Translation of research from the bench to clinical application is essential, and our researchers are highly regarded for their expertise as it applies to problems of high national relevance. Tangible benefits can be seen, for example, in the areas of health education, primary health care, healthy housing, mental health, inequality research, oral health, delivery of pharmaceutical agents, monitoring of medication use, rehabilitation, screening programmes for stomach cancer, preventive and/or treatment measures for obesity, diabetes, cardiovascular disease, asthma and childhood eczema. Ground-breaking scientific advances continue in the fields of cancer genetics, the neurosciences, infectious diseases, oral health, reproductive biology, and structural biology.

Researchers in the Division collaborate widely nationally and internationally, resulting in synergistic relationships between basic scientists and clinicians, and with partners in applied research and commercial settings.

The underfunding of health research in New Zealand is a major challenge facing the Division. One of the major roles of the Division is the training of New Zealand’s expanding health workforce. Research informs our teaching across all aspects of health professional training. For New Zealand to continue to be at the forefront of health research and training and to be internationally competitive in this environment, it is vital that there is significant further investment in health research funding within New Zealand.

The successes reported here reflect the Division’s commitment to research excellence. The report provides an overview of the research accomplishments of a large number of very able and dedicated people who strive to better the health of our community, and who work to address the needs of its most vulnerable and at risk members. I thank all in the Division of Health Sciences for their valuable contributions to what has been a period of significant growth and achievement.

Don Roberton Pro Vice-Chancellor Division of Health Sciences University of Otago

2 RESEARCH REPORT 2007/2008 CONTENTS

FROM THE PRO-VICE CHANCELLOR 2 EXECUTIVE SUMMARY 5 NOTES ON HOW THESE DATA ARE PRESENTED 6 THE DIVISION AT A GLANCE 7 RESEARCH HIGHLIGHTS 2007-2008 9 RESEARCH THEMES AND CENTRES 14 MÄORI HEALTH RESEARCH 30

FACULTY OF DENTISTRY 32 Department of Oral Diagnostic and Surgical Sciences 32 Department of Oral Rehabilitation 34 Department of Oral Sciences 35

FACULTY OF MEDICINE 38 OTAGO SCHOOL OF MEDICAL SCIENCES 38 Department of Anatomy and Structural Biology 38 Department of Biochemistry 42 Department of Microbiology and Immunology 46 Department of Pharmacology and Toxicology 49 Department of Physiology 51

DUNEDIN SCHOOL OF MEDICINE 54 Department of General Practice 54 Department of Medical and Surgical Sciences 55 Anaesthesia and Intensive Care 55 Bioethics 55 Medicine 57 Ophthalmology 59 Orthopaedic Surgery 60 Surgery 61 Department of Pathology 63 Department of Preventive and Social Medicine 65 Department of Psychological Medicine 69 Department of Women’s and Children’s Health 70

UNIVERSITY OF OTAGO, CHRISTCHURCH 73 Department of Anaesthesia 73 Department of Medicine 73 Department of Obstetrics and Gynaecology 77 Department of Orthopaedic Surgery and Musculoskeletal Medicine 78 Department of Paediatrics 80 Department of Pathology 81 Department of Psychological Medicine 84 Department of Public Health and General Practice 87 Department of Radiology 88 Department of Surgery 89 Centre for Postgraduate Nursing Studies 90

UNIVERSITY OF OTAGO, WELLINGTON 92 Department of Medicine 92 Department of Obstetrics and Gynaecology 94 Department of Paediatrics and Child Health 94 Department of Pathology and Molecular Medicine 96 Department of Primary Health Care and General Practice 97 Department of Psychological Medicine 99 Department of Public Health 100 Department of Radiation Therapy 104 Department of Surgery and Anaesthesia 104

Division of HEALTH SCIENCES 3 SCHOOL OF PHARMACY 106 SCHOOL OF PHYSIOTHERAPY 109 COMMERCIALISATION 111 COLLABORATIONS WITH EXTERNAL ORGANISATIONS 112 RESEARCH SUPPORT SERVICES 114 RESEARCH OFFICE 118 APPENDIX 1: PUBLICATIONS BY DEPARTMENT FOR 2007 119 APPENDIX 2: PUBLICATIONS BY DEPARTMENT FOR 2008 185 APPENDIX 3: DIVISIONAL ORGANISATIONAL CHART 239

From left: Dr Greg Jones, Associate Professor Tony Merriman and Dr Rebecca Roberts are researching the underlying genetics of common chronic conditions.

4 RESEARCH REPORT 2007/2008 EXECUTIVE SUMMARY

• The Division of Health Sciences is a research intensive Division with the highest overall annual research income within the University.

• The Division incorporates three campuses (Dunedin, Christchurch and Wellington) and comprises the following Schools and Faculties:

Faculty of Dentistry Faculty of Medicine Otago School of Medical Sciences Dunedin School of Medicine University of Otago, Christchurch University of Otago, Wellington School of Pharmacy School of Physiotherapy

A chart showing the organisational structure of the Division of Health Sciences is provided as Appendix 4.

• The University of Otago has established 13 Research Themes and 14 Research Centres for which the University is pre- eminent and to which it gives particular recognition and support. Researchers within the Division of Health Sciences are leaders of 9 of the Research Themes and 9 of the Research Centres.

• All Schools and Faculties have a strong research focus as evidenced by their successes in securing external income, their increasing numbers of postgraduate students, their high quality research outputs, and the many and varied honours and scholarships awarded to their staff and students. Details are provided for each School and Faculty in the following sections.

• The Division strongly encourages and supports the commercialisation of research results. Commercialisation activities include contract research, patents and licensing, and spin out companies.

• The Division has many diverse and valuable collaborations and affiliations with organisations external to the University of Otago. National and international connectivity and their associated benefits (e.g. co-funding opportunities, access to equipment, technologies and expertise) are viewed as crucial aspects of the Division’s research endeavours.

• The Division boasts extensive research support services including state-of-the-art research facilities and equipment, training opportunities, and staff expertise.

• The Division operates a Research Committee which is responsible for the dissemination of fellowships and funding as well as having a mentoring role for researchers. Research in the Division is further supported by the University’s Research and Enterprise Office which is the point of liaison between researchers and funding bodies.

Division of HEALTH SCIENCES 5 NOTES ON HOW THESE DATA ARE PRESENTED

This report contains information on the research activities of the Division of Health Sciences at the University of Otago, for the period 2007-2008.

The data contained within the report have been sourced from the University of Otago Research Master Database, from departmental websites, and from individual departments themselves. Every attempt has been made to ensure that this report is as complete and as accurate as possible, but given the diversity of activities and interests within the Division, there may be omissions or inaccuracies for which we apologise.

There are a number of important points that should be noted:

• Research grants and contracts have been attributed to the home department of each principal investigator. Where there were multiple principal investigators on a given grant or contract it is acknowledged that this will duplicate the listing of a small number of grants in this report.

• In a number of cases grants/contracts straddled departments and it is unfortunate that this report is unable to give credit to co-investigators who, while not listed here, did nevertheless contribute to securing research funding.

• This report lists details of external grants that were newly approved in 2007 and 2008. A significant number of grants approved prior to 2007 were also active throughout some, or all, of this period. Specific details of these grants are not included in this report. However, the total value of these grants is listed for each department. Further information about grants approved prior to 2007 is available in the Division of Health Sciences Research Report 2002-2006. http://healthsci.otago.ac.nz/research/reports.html

• Publications have been listed under the department of each author and co-author. This means that for these purposes specific publications may be listed more than once.

Other sources of information that may be of assistance to those interested in research within the Division of Health Sciences include:

The Division of Health Sciences website: http://healthsci.otago.ac.nz/research/index.html

Research and Enterprise Office, University of Otago: www.otago.ac.nz/research/index.html

Research Office, University of Otago, Christchurch: www.chmeds.ac.nz/research

Research Office, University of Otago, Wellington: www.wnmeds.ac.nz/Research/office.html

Research Office, Dunedin School of Medicine http://dnmeds.otago.ac.nz/research

6 RESEARCH REPORT 2007/2008 THE DIVISION AT A GLANCE

External Research Income in $ Million

Sources of External Research Grant Income for 2007/2008

Research Outputs

2004 2005 2006 2007 2008*

Journal Articles 967 1,021 957 844 1,122 All Publications 2,027 2,021 1,810 1,538 1,211

* Collation of 2008 publications is incomplete at this stage and the counts remain an estimate. It is expected that the total publication count for 2008 will increase significantly once conference proceedings are collected.

Division of HEALTH SCIENCES 7 University of Otago Scholarships Awarded

2005 2006 2007 2008

PhD Scholarship 23 27 51 66 Masters Award 12 10 16 10

Staff and Student Information

2007 2008

Equivalent Full-time Students Total 5,122 5,136 Undergraduate 4,047 4,042 Postgraduate 1,075 1,094 PhD 294 301 Masters (Research) 118 101

Full-time Equivalent Staff Academic and Research Only Staff 764 771 General Staff 651 672 Total Staff 1,415 1,443 Staff Headcount 1,917 1,757*

* There was a decrease in staff headcount from 2007 to 2008 but an increase in FTE staff. The likely explanation is that the Division employed more full time and fewer part time staff in 2008.

Headcount of PhD and Masters (by Research) Students*

* Headcounts as at 1 December each year. Masters by Research includes only Masters degrees where students undertake a significant research project and write a research thesis

8 RESEARCH REPORT 2007/2008 RESEARCH HIGHLIGHTS 2007-2008

Research Performance Indicators

~ External research income increased from approximately $53 million in 2007 to $63 million in 2008.

~ Our researchers published extensively with 1538 publications in 20071.

~ Marsden funding success: 16% of the total national Marsden pool was allocated to Divisional researchers in 2007 and 14% in 2008.

~ Health Research Council funding success: Divisional researchers received approximately 50% of the total funds allocated in the 2007 round and 33% in the 2008 round. Two new Programmes were funded in 2007 and two in 2008. All of these were awarded to Divisional researchers.

~ FRST success: In the 2007/2008 NERF round Otago had its best ever results. The Division attracted the University’s largest ever programme grant, $9.9 million for research to develop hand-held diagnostics and had three $1-1.7 million proposals approved around neuromuscular disorders, delivering drugs for Parkinson’s disease and developing human membrane- protein factories.

~ Performance Based Research Fund Evaluation In the 2006 research assessment, the University of Otago ranked number one in New Zealand for research quality. Division of Health Sciences staff contribute to our number one placing in the subject areas of Biomedical, Clinical Medicine, Public Health and Sociology2.

~ Leading Thinkers Since 2004, The Otago Leading Thinkers initiative has established a number of new high profile research positions in the Division of Health Sciences. Generally, the new positions have been funded by endowments that combine matched amounts contributed by a private donor and by the Government. Leading Thinkers initiatives during 2007 and 2008 leading to new positions now or in the near future within the Division are the: McAuley Chair in International Health; TD Scott Chair in Urology; Cure Kids Chair in Paediatric Research; and the Karitane Senior Research Fellowship in Early Childhood Obesity.

1 Collation of 2008 publications is incomplete at this stage. It is expected that the total publication count for 2008 will increase significantly once conference proceedings are collected. 2 Performance-Based Research Fund, Evaluating Research Excellence. The 2006 Assessment Tertiary Education Commission, Wellington, New Zealand, 2006. ISBN 978-0-478-087673.

Division of HEALTH SCIENCES 9 Research Outcomes

~ Lifecourse research Researchers from the two world leading longitudinal studies based in the Division, the Dunedin Multidisciplinary Health and Development Research Unit (DSM) and the Christchurch Health and Development Study (UOC) have guided policy development in various government departments. Examples include the development of both the New Zealand Suicide Prevention Strategy 2006-2016, and the Inter-Agency Plan for Conduct Disorder/Severe Antisocial Behaviour 2007-2012.

Members of the Dunedin Multidisciplinary Health and Development Research Unit. From left: Associate Professor Bob Hancox, Judith Sligo, Georgina Salter, Professor Richie Poulton, Diana Rothstein and Julie Buxton

~ Warmer homes make healthier people Research on the links between cold, damp housing and poor health outcomes carried out by UOW’s He Kainga Oranga, Housing and Health Research Programme, resulted in the inclusion of new targets in the 2007 New Zealand Energy Efficiency and Conservation Strategy. These targets include warm, dry homes, reducing energy costs, improving indoor air quality and reducing asthma by providing subsidies for the installation of insulation and heating for poorer households.

~ Smoking and cardiovascular disease A major international study involving researchers from the Dunedin School of Medicine’s Vascular Research Group has found that a common genetic variation that increases a person’s susceptibility to nicotine addiction, also increases their risk of lung cancer and arterial disease. Seven countries were involved in the study and the Vascular Research Group supplied information on close to 1000 case and control subjects from the Otago/Southland region. The findings have been published in the prestigious journal Nature3.

~ Childhood eczema Researchers from the Wellington Asthma Research Group (WARG) have shown that use of a probiotic supplement significantly reduces the rate of childhood eczema. A 50% reduction in eczema by the age of two was seen when the probiotic supplement Lactobacillus rhamnosus was given to women during pregnancy, for six months after birth while they were breast feeding, and then to their infants up until the age of two years. This is of significant clinical interest because eczema is unpreventable, it affects 30% of infants in New Zealand by the age of two and its prevalence is increasing.

3 Thorgeirsson T.E. et al (including Jones G.T., and van Rij A.M.). (2008). A Variant Associating with Nicotine Dependence, Lung Cancer and Peripheral Arterial Disease. Nature 452(3); 638-642.

10 RESEARCH REPORT 2007/2008 ~ Stomach cancer discovery Researchers from the Division’s Cancer Genetics Laboratory have discovered how a deadly form of stomach cancer develops and progresses. Hereditary diffuse gastric cancer runs in families including a large Mäori whänau in New Zealand. Tissue samples from stomachs removed from at risk whänau members, as part of a preventive surveillance programme, were studied in detail to reveal the mechanisms behind the cancer’s initiation and its invasive nature. Family members can now be tested and those affected can be carefully monitored and receive early treatment when tumours arise. It was also found that the mechanisms of cancer initiation and invasion are vulnerable to therapy with new types of drugs that are already in clinical safety trials for other forms of cancer.

Members of the Cancer Genetics Laboratory, Dr Bostjan Humar and Associate Professor Parry Guilford are studying stomach cancer.

~ Lack of sleep and obesity links Lack of sleep during childhood may be contributing to the increasing rates of adult obesity, according to new research from the Dunedin Multidisciplinary Health and Development Study. This longitudinal study has followed more than 1000 children born in Dunedin between 1972 and 1973. Findings show that children who spent less time in bed between ages 5 and 11 years had higher Body Mass Indexes as adults and were significantly more likely to be obese. This suggests that ensuring adequate sleep time in childhood may be an important strategy in the prevention of adult obesity in New Zealand.

~ Ngati and Healthy Diabetes Project The ‘Ngati and Healthy’ Project was a two-year community-based programme aimed at reducing diabetes risk factors in a Mäori community in the East Coast region of the North Island. The project was implemented by the Edgar National Centre for Diabetes Research based in the Dunedin School of Medicine. The programme involved health promotion, community education and tribal “buy-in” to the healthy lifestyles strategy. At the two-year endpoint, the number of people with diabetes in the region had stabilised and insulin resistance had decreased markedly in 25 to 49-year-olds.

~ Kisspeptin and ovulation Ground-breaking research by scientists in the Department of Physiology has revealed that kisspeptin, a small protein known to be vitally important for kick-starting puberty, also plays a critical role in the control of ovulation in the adult brain. It is possible that this finding may offer hope for some forms of infertility and also open up new avenues for contraception4.

4 Clarkson J, d’Anglemont de Tassigny X, Moreno AS, Colledge WH, Herbison AE. Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. Journal of Neuroscience 2008, 27;28(35):8691-7.

Division of HEALTH SCIENCES 11 ~ Internet depression treatment The Division’s Injury Prevention Research Unit launched a large-scale trial of a web-based self-help programme for treating depression. The trial is based on an Australian-developed online programme using cognitive behaviour therapy. The study is using a randomised controlled trial to evaluate two promising interventions. It will explore the acceptability of the two programmes for the population as a whole and for Mäori.

~ Gene screening technique pioneered Genetics researchers from the Department of Biochemistry, in collaboration with Myriad Genetics at Salt Lake City, have developed a new technique that makes large-scale gene screening (whole genome scanning) much cheaper. Researchers have focused on single nucleotide polymorphisms (SNPs), small changes in the DNA sequence between one person and the next. The new Affymetrix technology allows the pooling of DNA from many people suffering from a disease (rheumatoid arthritis in this case) which can then be compared to a pooled control genotype to reveal any differences.

~ Publications in Nature and Nature Genetics • Jenkins ZA, van Kogelenberg M, Morgan T, Jeffs A, Fukuzawa R, Pearl E, Thaller C, Hing AV, Porteous ME, Garcia- Miñaur S, Bohring A, Lacombe D, Stewart F, Fiskerstrand T, Bindoff L, Berland S, Adès LC, Tchan M, David A, Wilson LC, Hennekam RC, Donnai D, Mansour S, Cormier-Daire V, Robertson SP. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics Epub 2008 Dec 14. • Morison IM, Cramer Bordé EM, Cheesman EJ, Cheong PL, Holyoake AJ, Fichelson S, Weeks RJ, Lo A, Davies SM, Wilbanks SM, Fagerlund RD, Ludgate MW, da Silva Tatley FM, Coker MS, Bockett NA, Hughes G, Pippig DA, Smith MP, Capron C, Ledgerwood EC. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics 40: 387-389. • Thorgeirsson TE, et. al (including Jones GT, and van Rij AM). (2008). A variant associating with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452: 638-642. • Warren WC, et al. (including Gemmell NJ) (2008). Genome analysis of the platypus reveals unique signatures of evolution. Nature. 453:175-183.

Awards and Accolades

~ Professor Philippa Howden-Chapman from the Department of Public Health, University of Otago Wellington, received two national awards for her outstanding research contributions to housing and health: the Dame Joan Metge Medal from the RSNZ for capacity building in social science research and the Liley Medal from the HRC for the most influential research paper in the previous year.

Housing and health researcher Professor Philippa Howden-Chapman was the 2008 recipient of the Joan Metge Medal and the Liley Medal.

12 RESEARCH REPORT 2007/2008 ~ In 2008, Professor Christine Winterbourn from the Department of Pathology, UOC was awarded the Trevor Slater Award from the International Society for Free Radical Research.

~ Associate Professor Annette Beautrais from the Department of Psychological Medicine, UOC was honoured with the 2008 American Foundation for Suicide Research Award.

~ Professor Dave Grattan from the Department of Anatomy and Structural Biology is the new Editor-in-Chief for the Journal of Neuroendocrinology.

~ Carrying on a trend of first placings in recent years, students from the Division were awarded prizes in the MacDiarmid Young Scientist of the Year Awards in 2007. Natalie Harfoot (Physiology) won the Science and Society category, while postdoctoral researcher Shieak Tzeng (UOW) was first equal in the Advancing Human Health and Wellbeing category.

~ Two of the Division’s staff members were elected to Fellowships of the Royal Society of New Zealand in 2007 (Professors Allan Herbison and Clive Ronson), and one in 2008 (Professor Gregory Seymour).

~ In 2008, Professor Mark Richards from the Department of Medicine, University of Otago, Christchurch was awarded the Royal Society of New Zealand Sir Charles Hercus Medal for research in Biomedical and Clinical Sciences.

Equipment

~ Purchase of Sequencers In 2007, the Department of Anatomy and Structural Biology purchased a Roche GS FLX machine and in 2008 added an ABI SOLiD to establish a high-throughput sequencing facility. The facility is producing large quantities of data, changing the nature of research being carried out and opening up new collaborations.

~ New Zealand Genomics Consortium An Otago proposal to the Ministry of Research Science and Technology’s (MoRST) Research Infrastructure Advisory Group has resulted in the establishment of the New Zealand Genomics Consortium (NZGC). The NZGC will provide a collaborative national infrastructure for the provision of advanced genomics technologies, with the goal of making these vital research tools both accessible and affordable for New Zealand scientists. By providing access to a collection of highly sophisticated technologies, this infrastructure will bring together many scientists working on completely different life forms, enabling important experiments studying genetic variation and gene expression to be performed entirely within New Zealand.

~ Large Equipment The Division secured funding from the University’s Large Equipment Fund towards the following equipment in the 2007 and 2008 rounds: A LC_ESI QTRAP Hybrid Mass Spectrometer (Biochemistry) A Triple Quadropole Mass Spectrometer with Liquid Chromatography (UOC) An ABI3730XL Automated DNA Sequencer (Anatomy and Structural Biology) A Smart-EquiTest Balance System (Physiotherapy) An ABI3130 Genetic Analyser (UOC)

Collaborations

~ The Centre for Reproduction and Genomics was launched in December 2008 and represents a collaborative venture between AgResearch, New Zealand’s leading pastoral and livestock research institution, and the University of Otago.

~ The International Health Research Network, based in the Department of Preventive and Social Medicine, DSM, was officially recognised as a new Research Theme by the University.

Division of HEALTH SCIENCES 13 RESEARCH THEMES AND CENTRES

Research Themes and Centres are areas of research and/or collaborative groups of researchers in which the University of Otago is pre-eminent and to which it gives particular recognition and support. Researchers within the Division of Health Sciences are leaders of a significant number of the University’s Research Themes and Centres. Details are given below. Further information relating to the research grants and publications of specific researchers can be found in this report under a given researcher’s home department.

RESEARCH THEMES

Formulation and Delivery of Bioactives

Director: Professor Ian Tucker, School of Pharmacy

Website: http://pharmacy.otago.ac.nz/pages/research.html

Bioactive materials such as drugs, vaccine antigens, pesticides and nutrients cannot be administered in pure form but must be incorporated into biocompatible formulations which maintain the stability of the bioactive material and deliver it in a suitable way to achieve optimal beneficial effects while minimising unwanted side effects. Thus the science of formulation and drug delivery has human, veterinary and agricultural applications. It combines physical chemistry, biology and materials science to investigate physico-chemical properties of bioactives, excipients and formulations and behaviours of bioactives and formulations in the biological environment in order to develop an underpinning science. This science is the basis for design and manufacture of delivery systems with predictable behaviours.

Work includes: chemical stability of drugs in formulations; physical stability in formulations; colloidal systems for delivery of vaccine antigens; methods to characterise bioactives in the solid state; studies of the barriers to delivery of drugs (e.g. to the brain); delivery of poisons or vaccines to possums for control of Tb; oral delivery of peptide drugs; microencapsulation technologies; research and development of new therapies for mastitis in dairy cattle.

Major research goals: • To understand the barriers to delivery of bioactives. These include metabolic diffusion and transporter barriers. • To increase the bioavailability of drugs which are small organic molecules. These are classical drugs. • To develop novel approaches for the delivery of biopharmaceuticals (e.g. peptide and protein bioactives).

Research outcomes: • A subcutaneous implant for the delivery of Vitamin B12 to lambs and calves is now marketed in New Zealand. • Ground breaking research is being conducted in collaboration with the Cavendish laboratory, University of Cambridge and TerraView, on the use of terahertz spectroscopy to image pharmaceuticals.

Functional Genomics, Gene Expression and Proteomics

Director: Professor Warren Tate. Coordinators: Associate Professors Keith Farnden and John Cutfield: Department of Biochemistry, Otago School of Medical Sciences

Website: http://biochem.otago.ac.nz/FGGEPtheme/home.html

The era of high throughput automated DNA sequencing and genome databases (genomics) has become an important landscape for biologists and, with it, have come new methods for identifying particular genes and their protein products (proteomics).

It is the expression of a set of genes in a particular cell type that defines the function of that cell. The pattern of gene expression can change (e.g. during development or as a result of mutation or disease) so that analysis of altered expression profiles provides fundamental information on basic biological processes. However, understanding how such changes come about requires knowledge of factors that control gene expression as well as the functions of the individual protein products. Assigning function to a protein depends strongly on knowing its precise composition and three-dimensional structure. Functional proteomics leads, in turn, to a deeper understanding of physiological processes.

Such genome-to-proteome studies rely on sophisticated technology now in place on the Otago campus that can be applied to the study of any tissue or organism. The facilities include state-of-the-art mass spectrometry and X-ray analysis for proteins, as well as a gene microarray suite, all of which have received generous support from the University. Underpinning these operations is the use of advanced methods in computational biology (bioinformatics). A number of proven investigators are embracing these new technologies with the common goal of understanding or manipulating gene expression. In addition

14 RESEARCH REPORT 2007/2008 to using common methodologies, members of this theme share a similar intellectual approach to the analysis of genes and proteins, despite the great diversity among the organisms they are studying.

Major research goals: • To support the acquisition of cutting edge experimental skills and technologies in Genomics and Proteomics among theme members. • To develop research skills and awareness among developing students and emerging researchers. • To advance new knowledge in genomics and proteomics among theme members.

Research outcomes: • The theme provided support for 19 young scientists to participate in key Australasian and international meetings. • The theme co-sponsored a very successful Otago Genomics Facility Microarray Meeting in February 2008.

Annual report: The 2007 and 2008 Annual Reports can be accessed at:

Website: http://biochem.otago.ac.nz/FGGEPtheme/home.html

Immunological Basis of Disease and Protective Immunity (Immunet)

Director: Associate Professor Margaret Baird: Department of Microbiology and Immunology, Otago School of Medical Sciences

Website: http://immunet.otago.ac.nz/

An understanding of the immune response underpins our understanding of infectious and autoimmune diseases. Cures for these diseases, as well as cancer and asthma, require knowledge of the immune response and how it can be manipulated. Basic and applied research is essential for the health of both people and economically important livestock.

Research carried out by members of this theme focuses on the development of vaccines against cancer and infectious diseases such as Chlamydia, Johnes Disease and tuberculosis. It also seeks to understand the immunology of autoimmune inflammatory diseases and the role of the immune system in asthma and other allergies.

Nine research groups, comprising more than 40 senior researchers, are working on research projects that can be grouped under this theme, termed ‘Immunet’. These include immunologists in Crown Research Institutes and industry, some of whom have achieved international eminence.

It is with great sadness that the members of this Research Theme report the death of Associate Professor Glen Buchan in April Associate Professor Buchan was the instigator and inaugural Director of ‘Immunet’. His contribution to the establishment of this Research Theme was simply enormous. His legacy will be seen in the continuing success of immunologists in New Zealand.

Major research goals: • To promote the national and international reputation of the University of Otago as a centre for excellence in immunological research and education • To foster research collaborations between immunologists and allied disciplines • To improve public awareness of the importance of basic and clinical immunological awareness in the future of New Zealand.

Research outcomes: • In 2007/8 Immunet members published more than 50 papers in high/medium impact journals e.g. Journal of Immunology, European Journal of Immunology. Members of the theme have also secured substantial support from national funding bodies e.g. the Marsden Fund ($>500,000), the New Economy Research Fund ($7,000,000) and LactoPharma (>$400,000). Some of these projects involve cross-disciplinary research with participants both internal and external to the University. • The theme has also been integral to the formation of the Flow Cytometry Centre of Technology which will formally begin operation in 2009. • It is a pleasure to report that two of our members were elected as Fellows of the Royal Society of New Zealand this year: Professor Bryce Buddle, an AgResearch collaborator on several current immunological research projects with staff of this University, and Professor Greg Seymour, Dean of the Dental School.

Division of HEALTH SCIENCES 15 International Health Research Network

Director: Professor Philip Hill: Department of Preventive and Social Medicine, Dunedin School of Medicine

Website: http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/network/index.html

The Centre for International Health is the host of the newly established International Health Research Network. The new McAuley Chair of International Health is based in the Centre. The Chair is part of the Leading Thinker’s initiative of the University and has been established through a donation from the Mercy Hospital Dunedin, matched by the New Zealand Government. The Centre and Network will build on the University’s established strength in such fields as public health, human nutrition and infectious diseases, and will help fulfil the commitment to international progress, including the needs of people in the developing world.

The Network’s mission is to contribute to improving the health and well-being of people in developing countries through research and postgraduate training. There will be a particular focus on the needs of the Pacific region. The Centre will offer research-based postgraduate training and qualifications to people from developing countries in Asia, the Pacific and Africa, so they can become leaders at home.

Major research goals: • To foster increased collaboration between researchers already doing research in developing countries in relation to health • To monitor international health funding opportunities • To facilitate the interaction between staff at the University of Otago and international health researchers from other countries by hosting pre-eminent international health researchers at the university for seminars and symposia • To identify and develop new ways to develop the international health collaborations across the university

Oral Microbiology and Dental Health

Director: Dr Geoffrey Tompkins: Department of Oral Sciences, School of Dentistry

Website: http://dentistry.otago.ac.nz/research/oralmicro/index.html

Oral microbes cause discomfort, distress, and disease in a large proportion of the population. For example, ‘tooth decay’, which is caused by the bacteria present in dental plaque, is one of the most common human diseases. It is painful and it is costly to treat. Other microorganisms, such as periodontal pathogens and the yeast Candida albicans, are also present in the mouth and can give rise to oral diseases.

The Oral Microbiology and Dental Health (OMDH) theme comprises a number of pre-eminent research groups investigating various aspects of oral microbiology and dental health. These groups come from a variety of backgrounds including: the Faculty of Dentistry; the Department of Microbiology and Immunology, (Otago School of Medical Sciences); the Department of Pathology and Molecular Medicine (University of Otago, Wellington) and the New Zealand Dental Association.

Research carried out by members of the OMDH research theme covers a broad and cross-disciplinary range of topics, including the study of the microorganisms responsible for a range of oral diseases, understanding how these diseases are caused, and devising strategies to prevent them. Specific areas of study include: oral biofilms; plaque mineralisation; microbial adhesion; drug resistance; designer antimicrobials; bacteriocins; dental epidemiology; forensic dentistry; mining microbial genomes; and iron acquisition.

Major research goals: • To understand the interactions between oral microorganisms and human populations • To understand how oral microorganisms cause oral disease • To devise new strategies to overcome oral microbial disease

Research outcomes: • Overcoming microbial drug resistance. A major problem in the treatment of patients with microbial infections is that the microorganisms can develop resistance to the prescribed drugs. Often this resistance is caused by microbial proteins that pump the drugs out of the cell. Researchers in the OMDH Research Theme have identified that the main cause of the resistance shown by the fungal pathogen Candida albicans to azole antifungal drugs is the pump protein CaCdr1p5. Furthermore, they have discovered a potential pump inhibitor that may overcome azole drug resistance. This has led the researchers to propose, in the prestigious journal Science, new approaches to outwitting fungal multidrug resistance6.

5 Holmes, A.R., Lin, Y-H., Niimi, K., Lamping, E., Keniya, M., Niimi, M., Tanabe, K., Monk, B.C. and Cannon, R.D. (2008) ABC transporter Cdr1p contributes more than Cdr2p to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrobial Agents and Chemotherapy 52:3851-3862. 6 Monk, B.C and Goffeau, A. (2008) Outwitting multidrug resistance to antifungals. Science 321:367-369.

16 RESEARCH REPORT 2007/2008 • In October 2008, BLIS Technologies Ltd announced a marketing and distribution agreement with Frutarom Ltd which will be responsible for the global promotion and sales of the company’s lead product, BLIS K12. The agreement with Frutarom is in addition to the existing commercial relationship that BLIS has with Nestle, Switzerland, which provides Nestle the global rights to use BLIS K12 in their infant formula. • Prevention of dental caries by a plaque mineralising toothpaste. Researchers in the OMDH Research Theme at UOW have developed an innovative new approach to counter dental caries that deposits a tooth-like mineral into dental plaque by using a toothpaste containing calcium, phosphate, and monofluorophosphate. This will help protect the enamel from acid dissolution, enhance remineralisation and modify plaque microbial composition. A pilot trial will be carried out early next year with students at UOW to determine the level of mineral deposited into dental plaque. This will lead to a definitive home-based clinical trial involving high risk schoolchildren in Christchurch7.

Annual report: The 2007 Annual Report can be accessed at: http://dentistry.otago.ac.nz/research/oralmicro/news.html

Oxidative Stress in Health and Disease

Director: Professor Christine Winterbourn: Department of Pathology, University of Otago Christchurch

Website: www.uoc.otago.ac.nz/research/freerad/

Oxidative stress occurs when the production of damaging free radicals and other oxidative molecules exceeds the capacity of the body’s antioxidant defences to detoxify them. Oxidants also play an important positive role in the immune system. Because we live in an oxygen rich environment, oxidant production and control are integral life processes. These can be disrupted, however, and oxidative stress contributes to many diseases including inflammation, autoimmune disease, cancer, neurodegenerative diseases, heart attack, stroke and ageing. Understanding how this occurs requires interdisciplinary research at several levels, from basic chemistry and biochemistry through physiology, nutrition and pathology to medicine, surgery, pharmacy and pharmacology. Members of the theme are drawn from different Divisions, spread across three campuses, and include biochemists, clinicians and nutritionists.

Current projects include: mechanisms of antioxidant defence, nutritional antioxidants, antimicrobial and anti-inflammatory activities of neutrophil oxidants, mitochondrial oxidants and apoptosis, synthesis of mitochondrially targeted antioxidants, redox regulation of cell signalling, regulation of hypoxia-inducible factor activity, iron-sulphur proteins, myeloperoxidase and cardiovascular disease, hypoxia/ischemia injury, and the involvement of oxidative stress in neonatal lung disease, kidney disease and cystic fibrosis.

Major research goals: • To hold annual meetings to foster scientific interaction between Theme members. • To facilitate the initiation of collaborative projects between Theme members. • To encourage exposure to the field by supporting invited seminar speakers and providing grants-in-aid to young investigators for conference attendance.

Research outcomes: • Senior authorship (Dr Liz Ledgerwood) on a publication in Nature Genetics describing how a mutation in the cytochrome c gene affects the apoptotic pathway with resultant thrombocytopenia8. • In 2008, Professor Christine Winterbourn was awarded the Trevor Slater Medal for lifetime achievement in the field by the International Society for Free Radical Research.

7 This research is a collaboration between the Dental Research Group (UOW), Dr Natalie Medlicott (School of Pharmacy), Dr Martin Lee (School and Community Dental Services, Canterbury DHB), Dr Rose Mary Jones (Dental and Oral Health Service, Capital and Coast DHB), Paul Mather (Wellington Institute of Technology), and has commercial involvement from Carl Alexander (PBL Technologies Ltd). The toothpaste development was a finalist for an Otago Innovation Proof of Concept Grant 2007. 8 Morison IM, Cramer Bordé EM, Cheesman EJ, Cheong PL, Holyoake AJ, Fichelson S, Weeks RJ, Lo A, Davies SM, Wilbanks SM, Fagerlund RD, Ludgate MW, da Silva Tatley FM, Coker MS, Bockett NA, Hughes G, Pippig DA, Smith MP, Capron C, Ledgerwood EC. (2008). A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nature Genetics 40: 387-389.

Division of HEALTH SCIENCES 17 Rehabilitation and Disability

Director: Professor David Baxter, School of Physiotherapy

Website: www.rehabotago.net/

The Rehabilitation and Disability Research Theme represents a collaborative effort by researchers from diverse backgrounds. These researchers conduct high quality research that will enhance the effectiveness of rehabilitative care and optimise quality of life for persons with injury and disabilities, including those musculoskeletal, neurological, and chronic health conditions that may lead to impairment and/or disability.

Research that will improve the quality, effectiveness, and cost-effectiveness of patient care and outcomes is undertaken. This includes investigations focusing on the prevention, reduction and resolution of disability, as well as quality of life for those affected by injury or disability, and the quality of life of their families and carers. Work in this area is based upon applied research that utilises modern technology to maximise human performance, and facilitate the process of adaptation to disability; research that improves understanding of the determinants of adaptive human performance and disability within the context of impairment and/or disability; as well as investigations into the accessibility and effectiveness of patient/family education and community outreach programs. The Rehabilitation and Disability Research Theme provides research training in a variety of specialties, including rehabilitation, neuroscience, neuropsychology, biomechanics, health care outcomes, rehabilitation engineering, and other related fields.

Due to the wide scope of our members’ specialties, from clinicians to academics, doctors, physiotherapists, health practitioners, and qualitative to quantitative researchers, we believe that a wealth of knowledge, understanding and ideas are being generated through current collaborations. This is evidenced through the range of new PhD candidates as supervised by the Theme (HRC Disability Placement Programme Scholarships support three of these students), new research groups centred around theme-specific foci and collaborative tender responses.

Major research goals: • The development of our annual colloquium into a conference-sized meeting, with the aim of it becoming self-sufficient by 2012. • To submit an application (preferably for a Programme grant) to an HRC grant round prior to 2012. • The development of focused areas for future collaboration, e.g. low back pain.

The Kidney in Health and Disease

Directors: Professor Rob Walker, Department of Medical and Surgical Sciences, Dunedin School of Medicine, Professor Zoltan Endre, Department of Medicine, University of Otago, Christchurch.

Website: http://kidney.otago.ac.nz/

This theme involves approximately 20 researchers from the University of Otago, Christchurch, the Dunedin School of Medicine, and other departments and schools in the Division including the Departments of Physiology, Pharmacology and Toxicology, and the School of Pharmacy. The School of Physical Education is also involved. Strong links have been established between the researchers and District Health Boards, and with other research institutions nationally and internationally.

The Group is dedicated to investigating innovative ways to prevent and treat kidney disease. The group’s expertise ranges from molecular and cellular-level investigations of kidney function, to applying therapies to prevent kidney injury or the progression of kidney disease. Research is aimed at better understanding the mechanisms of insult to the kidney, so as to allow earlier detection and better treatment. Efforts are underway to find new markers for early acute renal failure so it can be treated before irreversible damage or death occurs. Current research projects include: effects of lithium on renal function; molecular biology of polycystic kidney disease; dietary induced obesity and metabolic syndrome; clinical renal trials; renal function and high performance exercise; and progression of renal disease.

Major research goals: To determine: • The role of urinary biomarkers in identifying acute kidney injury. Researchers have just completed the first prospective double blind randomised clinical trial in the prevention of acute kidney injury in patients admitted to the ICU where acute kidney injury was identified by a rise in urinary biomarkers rather than a rise in plasma creatinine. Results will be published in early 2009. • Mechanisms of lithium-induced tubular injury. The Group has an ongoing clinical and experimental research programme investigating the aetiology of chronic kidney injury due to lithium therapy. • Mechanisms of fibrosis in models of polycystic kidney disease. We have a unique sheep model of autosomal recessive polycystic kidney disease which we are characterising the genetic and phenotypic characteristics. We are also investigating the alterations in primary cilia and cellular signalling processes in these models.

18 RESEARCH REPORT 2007/2008 Research outcomes: • The theme has had 70 publications to date since the theme waas established. • The theme has generated over $2 million in research funds. • A very successful satellite meeting on ‘molecular mechanisms in kidney disease’ was run in conjunction with the Queenstown Molecular Biology Meeting. Guest speakers included Professor Jeff Sands from Emory University, Atlanta, USA and Dr David Weiner from the University of Florida, Gainsville, USA.

Virology

Directors: Associate Professor Vernon Ward and Professor Andrew Mercer, Department of Microbiology and Immunology, Otago School of Medical Sciences

Website: http://mrna.otago.ac.nz/Virology/Virology.html

The Virology research team comprises several inter-connected groups located in the Divisions of Sciences and Health Sciences, and spread across the Dunedin and Christchurch campuses. Together, they have expertise in all areas of virology. Current research activities of the groups encompass multiple projects in the areas of: • viruses and their role in cancer • using viruses to deliver vaccines • structural virology • viruses as building blocks for nanomaterials • human and animal health virology • respiratory and gastrointestinal diseases • antiviral drugs • viral infections and their rapid diagnosis • vector-borne diseases: plagues past, present and future • invertebrate virology: biocontrol agents for insect pests • plant virology: threats to food security and conservation

The group has an exceptionally strong track record of publications, and collaborates internationally with research institutes in Canada, Germany, the Netherlands, Britain, the United States, Australia, Finland and Israel. Theme participants have won in excess of $11.5 million of funding for virology research from both national and international sources in the last five years.

Major research goals: • To decipher the interactions between viruses and their host • To generate beneficial products derived from the properties of viruses or viral products • To increase our fundamental knowledge of viruses, viral replication and the biology of viruses

Research outcomes: • A major achievement has been the reverse engineering of the norovirus for the first time9. This will facilitate the study of the virus which cannot be grown under normal culture conditions. • The pandemic preparedness work of Dr Lance Jennings at the Christchurch School of Medicine. This research has been funded by a $1.6m research grant from the Centre of Disease Control to investigate influenza in international travellers into Christchurch. • Sonnberg, S., Seet, B.T., Pawson, T., Fleming, S.B., and Mercer, A.A. (2008). Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. Proceeding of the National Academy of Sciences, USA 105:10955-10960.

Memory: Mechanisms, Processes and Applications

Directors: Associate Professor David Bilkey, Dr Anthony Robins, Department of Psychology, University of Otago

Website: http://psy.otago.ac.nz//memory/

Although this theme is not led by a member of the Health Sciences Division, Divisional staff have significant input into it. Please refer to the website above for further information.

9 Ward, V.K., McCormick, C.J., Clarke, I.N., Salim, O., Wobus, C.E., Thackray, L.B., Virgin, H.W., and Lambden, P.R. (2007). Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA. Proceeding of the National Academy of Sciences, USA 104:11050-11055.

Division of HEALTH SCIENCES 19 RESEARCH CENTRES

Cardioendocrine Research Centre

Director: Professors Mark Richards and Gary Nicholls, Department of Medicine, Otago University Christchurch

Website: www.chmeds.ac.nz/research/cardioen/

The Cardioendocrine Research Centre is expanding New Zealand’s capacity in cardiovascular research across the spectrum of basic and applied biomedical science to gain new knowledge of the processes determining the structure and function of the heart and blood vessels in health and disease. Common among all New Zealanders, heart disease is especially devastating to Mäori and Pacific Islands people, and affects many people in mid-life, imposing a special national burden through health-care costs, loss of productivity and reduction in life expectancy.

The Centre’s areas of interest include: • bio-molecules with pivotal roles in cardiovascular health and disease • gene variants associated with heart disease risk • pre-clinical assessment (isolated organ and intact animal studies) of the release and the actions of newly-discovered proteins and hormones in health and disease • disease-related changes in mechanical, chemical and electrical aspects of heart cells and tissue • prevalence of cardiovascular risk factors and established disease in Mäori and non- Mäori • clinical testing of new tests for diagnosis and prediction of clinical outcomes • trials of novel interventions in disorders such as heart failure

These studies are revealing the “signature” of heart disease in New Zealand and will facilitate effectively planned long-term responses, including new screening, diagnostic and therapeutic options to secure the cardiovascular health for the nation’s future. National contributions to economic transformation will accrue through the reduction of the financial and social burden of heart disease carried by New Zealanders, through the improved ability of New Zealand researchers to attract funds and through intellectual property brought to the market in diagnostic and therapeutic products.

Major research goals: • to advance basic and clinical research in circulating and tissue-based factors pertinent to the control of the circulation in both health and disease, with the aim of applying this new knowledge to the diagnosis, prognosis and therapy of human cardiovascular disease.

Research outcomes: • Clinical studies into the association between levels of circulating biomarkers, genetic variations and cardiac imaging features as indicators of clinical outcome, continue with expanding cohorts of patients, e.g. the Coronary Disease Cohort Study has recruited close to 2000 patients; the recently completed ‘BATTLESCARRED’ trial of hormone-guided treatment for heart failure has produced improvements in patient outcomes; and the Community Heart Study has gathered data on urban and rural Mäori and is now recruiting a non- Mäori cohort. • The ‘Homeostasis Study’ is an international collaboration with the bioengineering and device company, St Jude Medical (USA) and involves the testing of a fully implantable device for direct measurement of left atrial pressure. The first device has been implanted in a patient in Christchurch and the procedure has yielded much important information. • The Biochemistry Peptide Laboratory at the Centre has revealed a role for the BNP signal peptide as a clinically applicable biomarker for cardiac injury. This has led to the filing of national and international patents for intellectual property protection for the BNP signal peptide as well as for other candidate signal peptides. • Genotyping of patient cohorts with heart failure and coronary syndromes continues and will expand under the newly awarded HRC programme grant. At least 8 genetic polymorphisms associated with variations in clinical outcome in heart failure and coronary disease have already been discovered by the Group.

20 RESEARCH REPORT 2007/2008 Carney Centre for Pharmacogenetics

Director: Associate Professor Martin Kennedy, Department of Pathology, University of Otago Christchurch

Website: www.uoc.otago.ac.nz/research/carneycentre/

Pharmacogenomics is the study of how genes influence a patient’s responses to drugs. This research area is helping to clarify how genetic differences contribute to the risk of side effects or failure of drug treatment, and how we might better tailor treatment to each patient, leading to improved safety and effectiveness.

The Carney Centre for Pharmacogenomics was launched in May 2005, as a component of the University of Otago Leading Thinkers advancement campaign, and it received matching support from the government’s Partnerships for Excellence programme.

The Centre comprises a cluster of interacting research groups at the University of Otago and elsewhere, with a major focus in Christchurch. Together these groups span a wide range of clinical, pharmacological and genetic expertise. As a result, we have a strongly collaborative, multidisciplinary approach to pharmacogenomics with current research programmes in the following areas: mental disorders, particularly depression and bipolar disorder; inflammatory bowel disease; rheumatoid arthritis; asthma and airways disease; heart disease; and drugs in breast milk. We use a range of methods including pharmacokinetic and pharmacodynamic studies, analysis of genetic variation in relation to drug responses, and genomic or proteomic methods for examining molecular aspects of drug action.

Major research goals: • To carry out excellent research into pharmacogenomics, from molecule to bedside • To provide high quality postgraduate and medical training in pharmacogenomic areas • To disseminate pharmacogenomics information in ways that inform and improve clinical practice

Research outcomes: • Two DNA tests for drug response are being considered for licensing to a major USA diagnostics company • Numerous peer reviewed publications in the area of pharmacogenomics • A meeting that is becoming an established forum for New Zealand and Australian pharmacogenomics researchers has become an annual event

Annual report: The Centre’s Annual Reports can be viewed at: http://www.chmeds.ac.nz/research/carneycentre/reports.htm

Centre for Physiotherapy Research

Director: Dr Stephan Milosavljevic, School of Physiotherapy

Website: http://physio.otago.ac.nz/res/default.html

The Centre comprises an enthusiastic and skilled team of staff and research students involved in a variety of research programmes. Since 2007, the Centre has established a structure of recognised research groups to better support the development of research and to provide a more strategic focus for the Centre and for the profession. These groups comprise academic and clinical staff, and research students working in one of three themed areas: the AMOCK Research Group (Advancement of Musculoskeletal, Occupational Health and Clinical Knowledge); the REAL Neurological Research Group (Rehabilitative Exercise and Activity for Life); and the SPEX Research Group (Sport and Exercise Group).

The Centre has a well-developed network of research collaborators and maintains close links to other Health Science research groups at Otago, as well as maintaining relationships with other centres of research excellence within New Zealand and internationally. It is closely aligned with the University of Otago Rehabilitation and Disability Research Theme. In addition, the Centre boasts a new Clinical Research Suite and a range of facilities to support research, including a new Balance Laboratory equipped with a CRS Smart Equitest – the only one of its kind in the country.

Division of HEALTH SCIENCES 21 Centre for Reproduction and Genomics

Director: Professor Neil Gemmell, Department of Anatomy and Structural Biology and AgResearch

Website: www.crg.org.nz/

The Centre for Reproduction and Genomics (CRG) is a newly established collaborative venture between AgResearch, New Zealand’s leading pastoral and livestock research institution, and the University of Otago, New Zealand’s leading research university. It was officially launched in December 2008.

The CRG brings together world-class scientists from AgResearch and the University of Otago working across a broad spectrum of topics in reproductive biology, physiology, molecular biology, genetics and genomics. There is a particular focus on the following areas: livestock and human reproduction; livestock and human health and disease; and the control of animal reproduction. Currently, the Centre hosts three research teams from AgResearch and the University of Otago, each of which are led by senior scientists who are international leaders in their respective fields. These are the Reproductive Biology, Animal Genomics and Evolutionary Genetics Teams.

The Centre’s multi-disciplinary programmes involve integrated science capability teams, as well as collaboration with external science groups. An important part of the Centre’s remit is to establish and maintain strong links with national and international stakeholders, particularly those in the pastoral sector of New Zealand.

Major research goals: • To provide new knowledge to enhance or suppress reproduction in livestock, humans and other animal systems • To improve our ability to predict susceptibility to disease and illness in livestock, humans and other animal systems • To advance basic knowledge of reproductive and genomic biology • To develop technological advances in reproductive and genomic science

Centre for Translational Cancer Research

Director: Dr Parry Guilford: Department of Biochemistry, Otago School of Medical Sciences

It is known that drugs precisely delivered to molecular targets on the cancer cell can save lives, that early detection provides the simplest path to patient survival, that the body’s own immune system can be manipulated to eliminate disease, and that, with the right diagnostic tools, conventional cancer treatment can be individualised to radically improve the outcome for the patient. However, the incremental gains made in the research laboratory all too rarely reach the hospital oncology wards.

This Centre brings together scientists and clinicians from across New Zealand, enhanced by significant collaborations with elite international cancer groups with the aim of translating laboratory research to the clinic. The Centre provides unique training opportunities for young scientists and clinicians, and provides them with national and international networks to support them through a life of research and clinical practice. This highly coordinated, multidisciplinary team is developing an integrated strategic research and clinical programme to convert ground-breaking research into nationwide improvements in the diagnosis, management and treatment of New Zealand’s most pressing cancer problems, in particular, melanoma, colorectal and gastric cancer .

Edgar National Centre for Diabetes Research

Director: Professor Jim Mann, Department of Medicine, Dunedin School of Medicine

Website: www.otago.ac.nz/diabetes/index.html

The Edgar National Centre for Diabetes Research (ENCDR) was established as part of the University of Otago Advancement Campaign in November 2003. The ENCDR promotes collaborative research amongst those involved in diabetes-related research in departments in the University of Otago, and facilitates collaboration with researchers and health care providers throughout New Zealand and internationally. The research conducted at the centre involves a range of disciplines, including nutrition, epidemiology, health services research, Mäori health, biostatistics, public health, microbiology, genetics and biochemistry.

Our research aims to reduce the incidence of diabetes and its complications by finding new ways to prevent and manage diabetes. In addition to their research roles, members of the centre play a leading part in guideline and policy development at local, national and international levels. They are also involved in teaching at community and professional levels.

22 RESEARCH REPORT 2007/2008 Major research goals: • Our vision is to make significant contributions to reducing the global burden of diabetes through research and dissemination of knowledge.

Research outcomes: • APPLE (A Pilot Programme for Lifestyle and Exercise): This programme has demonstrated the feasibility of reducing excessive weight gain by a school and community lifestyle intervention programme. More information is available at: www.otago.ac.nz/diabetes/research/apple.html • Ngati and Healthy: Ngati Porou Hauora and the University of Otago collaborated to develop a programme for reducing the risk of diabetes amongst a high risk population on the East Coast of the North Island of New Zealand www.otago.ac.nz/diabetes/research/ngati.html • LOADD: This project aims to determine whether intensive lifestyle intervention improves glycaemic (blood glucose) control and cardiovascular risk factors in people with Type 2 diabetes who are on optimised drug treatment. www.otago.ac.nz/diabetes/research/loadd.html • Validation of a new clinical test for insulin sensitivity: Tests for the measurement of insulin sensitivity range from the extremely complex gold standard (the hyperinsulinaemic euglycaemic clamp) to simple static indices including HOMA and the McAuley index. We have developed, in collaboration with researchers at the University of Otago, Christchurch and the University of Canterbury a simple dynamic test which is undergoing further evaluation. It is hoped that this will be of value in identifying insulin resistant individuals as well as assessing measures aimed at reducing insulin resistance, a precursor state for Type 2 diabetes. www.otago.ac.nz/diabetes/research/insulintest.html • The Centre for Translational Research in Chronic Diseases (CTRCD): The CTRCD has developed as an arm of the ENDCR. The major project of the CTRCD at present is the evaluation of the implementation of the Healthy Eating Healthy Action: Oranga Kai Oranga Pumau Strategy (the HEHA Strategy). The CTRCD has formed a consortium with The Health Services Research Centre of Victoria University to carry out this evaluation for the Ministry of Health, over the next three years. This evaluation will provide a report on the effectiveness of the implementation of the HEHA Strategy as a national strategy in achieving the HEHA goals which are to improve nutrition, to increase physical activity and to reduce obesity for all New Zealanders. www.otago.ac.nz/ctrcd/index.html

Annual report: The 2007 annual report from the ENCDR can be accessed below: www.otago.ac.nz/diabetes/pdf/ENCDR%20Annual%20Report%202007.pdf

Mental Health and Addiction Research Centre

Director: Professor Peter Joyce: Department of Psychological Medicine, University of Otago Christchurch

The Mental Health and Addiction Research Centre (MHARC) brings together the research activities of the Mental Health Clinical Research Unit (Director, Professor Peter Joyce), the National Addiction Centre (Director, Professor Doug Sellman) and the Gene Structure and Function Laboratory (Director, Associate Professor Martin Kennedy). Linked with the centre are two University Leading Thinkers projects in Pharmacogenomics and Bipolar Disorder.

Mental disorders, such as depression, bipolar disorder, anxiety, eating disorders and alcohol and drug addictions are major contributors to the burden of disease for young New Zealanders and their families. The centre is actively involved in large- scale clinical trials in bipolar disorder, depression, bulimia, social anxiety disorder and alcohol dependence. In addition, the centre is actively involved in research on genetic markers of mood disorders, addictions and personality of subjects involved in clinical trials.

The centre is also involved in laboratory-based research on the molecular mechanisms of action of antidepressant drugs, the epigenetics of mental disorders and genetic polymorphism discovery in relationship to mental disorders.

Division of HEALTH SCIENCES 23 National Addiction Centre

Director: Professor Doug Sellman, Department of Psychological Medicine, University of Otago Christchurch

Website: www.uoc.otago.ac.nz/departments/psychmed/treatment/

The National Addiction Centre (formerly the National Addiction Centre (Alcohol, Drugs & Addiction) was established by the Alcohol Advisory Council of New Zealand (ALAC) in 1996 as a resource for the alcohol and drug treatment field of New Zealand. Its mission is a university-based national centre dedicated to developing and promoting effective interventions for people with alcohol, drug and addiction related problems in Aotearoa New Zealand. There are three main activities by which the National Addiction Centre aims to achieve its mission: research projects; teaching and training programmes; and consultation and liaison

Ongoing research projects include: Naturalistic Treatment Outcome Study – Five Year Follow-up; Youth Retention Study; Odyssey Youth Outcome Study; The Effectiveness of Naltrexone in Reducing the Craving of People with Pathological Gambling; Experiences and Needs of Mäori Methadone Maintenance Treatment Patients; Resilience in Indigenous Health Networks; Development of Mäori AOD Services and Workforce in Aotearoa New Zealand; Nicotine Maintenance Feasibility Trial; Pre-quit Nicotine Replacement Therapy Trial; The Alcohol and Drug Outcomes Project (ADOPT) – Part II.

Major research goals: • To improve the care and treatment available to people with alcohol and drug-related problems in New Zealand. • To develop and promote evidence-based practice in the alcohol and drug treatment area. • To contribute to a clinical culture in New Zealand alcohol drug treatment units that is responsive to research and treatment development.

National Centre for Lifecourse Research (NCLR)

Co-Directors: Professor Richie Poulton, Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive and Social Medicine, Dunedin School of Medicine and Professor David Fergusson, Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago, Christchurch

Website: www.lifecourse.ac.nz

The National Centre for Lifecourse Research (NCLR) was launched in November 2007. It is a partnership of researchers involved in longitudinal studies, social sciences, and demography. Headquartered at the Dunedin Multidisciplinary Health and Development Research Unit, its founding partners represent research groups from five universities and one crown research institute. All partner groups specialise in research about people throughout the lifecourse.

In addition to the Dunedin Study, other NCLR Founding Partners include the Christchurch Health and Development Study (Professor David Fergusson, University of Otago), Pacific Islands Families Study (Professor Janis Paterson, AUT University), Institute of Environmental Science and Research (ESR) (Dr John Hay), Otago Centre for Research on Children and Families (Prof. Gordon Harold), Roy McKenzie Centre for the Study of Families (Associate Professor Jan Pryor, VUW), and the Population Science Centre (Professor Richard Bedford, Waikato University). We anticipate that the new longitudinal study of New Zealand children and families, Growing Up in New Zealand (Dr Susan Morton), will also become a full NCLR partner. Affiliates include Associate Professor Elaine Reese (Department of Psychology) and the Centre for Science Communication (Professors Jean Fleming and Lloyd Davis).

Effective knowledge exchange is increasingly demanded by practitioners, policymakers, NGO’s and funding bodies. The NCLR adds value through a focus on the transfer and exchange of research findings to a range of such end-users outside of academia. Partner groups, meanwhile, continue with the research, publication, and academic dissemination of findings as their core business.

In practice it is difficult for individual research groups to dedicate the necessary financial, time and personnel resources to meaningfully engage their stakeholders. The NCLR focuses on that engagement using a three-pronged approach which is detailed below.

Major research goals: The NCLR will conduct and apply high-quality research that informs policy and practice to improve the lives of New Zealanders. This will be accomplished through three areas of focus: • Translational Research – producing a range of resources tailored to meet the information preferences and needs of external stakeholders;

24 RESEARCH REPORT 2007/2008 • New Research – enhancing New Zealand’s position as an international leader in lifecourse research by establishing and maintaining partnerships and collaboration, both national and international; • Capability Building – training the next generation of scientists in research and communication methods, the latter to engage the public and bring science to life in innovative ways.

Research outcomes: • The development of a website, a key avenue of dissemination to external stakeholders. • A study has begun which examines engagement with non-academic groups by health researchers, with the aim of establishing a quantitative research instrument that can be applied across New Zealand health research. • A third project focuses on identifying future niches for the NCLR from the viewpoint of potential stakeholders. This has been carried out in collaboration with the Integrative Research for Sustainability group within ESR. Participants have identified needs for knowledge brokering, a “clearinghouse” of information, and different avenues to build and maintain effective relationships between research and policy.

Annual report: The Centre’s 2008 Annual Report can be viewed at: www.lifecourse.ac.nz/outputs/Annual_Reports.php

National Poisons Centre

Director: Dr Wayne Temple, Department of Preventive and Social Medicine, Dunedin School of Medicine

Website: www.poisons.co.nz

The National Poison Centre is a service unit within the Department of Preventive and Social Medicine at the Dunedin School of Medicine. The Centre is co-located with the School of Pharmacy and the academic departments of Pharmacology and Toxicology, and Preventive and Social Medicine. Currently, the Centre is funded by contracts with the Ministry of Health and the ACC, with support from the University and other agencies.

The NPC answers enquiries both from health professionals and from the general public concerning acute poisoning and the toxic effects of chemicals, which may be encountered in emergencies of any sort. This service operates 24 hour per day 365 days per year. The Centre receives close to 35,000 enquiries per year.

The Centre maintains a computerised database (TOXINZ) currently listing more than 165,000 chemical and medicinal products, as well as hazardous plants and animals found in New Zealand. Medicines and pesticides information is furnished from Government agencies while manufacturers and distributors provide information for other commercial products on a voluntary basis. The TOXINZ database receives approximately 45,000 enquiries per year from registered users. The Centre has also developed a computerised record of all enquiries regarding actual or potential toxic exposures, utilising a poisoning incident report format.

In the area of injury prevention, the Centre provides poison prevention information to the general public by way of advice, resources and public displays/seminars. It also has a poisons prevention and education website which is aimed at parents/ caregivers and educators. The website (www.poisons.co.nz) was launched in October 2006.

The NPC participates with the International Programme on Chemical Safety (WHO/ILO/UNEP). Locally, the Centre is represented on the Dunedin Hazardous Substances Technical Liaison Committee and the Emergency Services Executive Co-ordinating Committee.

Major research goals: • A reduction in the number and severity of incidents of accidental poisoning through the provision of both prevention information and timely, accurate treatment advice.

Research outcomes: • Recent examples of toxicovigilance were: the notification by the Centre of the toxic Bindeez Beads in November 2007, which resulted in the beads being withdrawn from sale; and the recent toxic honey exposures. • The Centre’s website attracts around 10,000 visitors annually.

Annual report: The NPC’s 2008 Annual Report can be viewed at: www.poisons.co.nz/otherinfo.php?c=5

Division of HEALTH SCIENCES 25 Neuroendocrinology Research Centre

Directors: Professor Allan Herbison, Department of Physiology, Otago School of Medical Sciences, Associate Professor Dave Grattan, Department of Anatomy and Structural Biology, Otago School of Medical Sciences

Website: http://www.otago.ac.nz/neuroendocrinology/

The Centre for Neuroendocrinology (CNE) is comprised of eight laboratories investigating the neural control of reproduction, fluid volume homeostasis and catecholamine secretion. The CNE is the largest cluster of neuroscientists of its kind in the world. The Principal Investigators within the CNE come from the Departments of Physiology, and Anatomy and Structural Biology in Dunedin and Obstetrics and Gynaecology at the University of Otago, Christchurch.

Current research focuses on understanding the mechanisms through which the hypothalamus controls fertility, pregnancy, lactation, reproductive behaviour, body weight, stress responses and fluid volume homeostasis in the adult mammal. Studies are also undertaken to examine the development of these neural circuits and the ways in which circulating hormones act back on the brain. Investigations are focused upon understanding both the physiology and pathophysiology of these neuroendocrine circuits. The principal experimental model used is the rat and mouse with particular expertise within the group in the development and use of transgenic mouse models. A full listing of projects and details of the CNE is available at the website given above.

Major research goals: • To understand the neural and endocrine control of reproduction • To understand the neural control of body weight and fluid homeostasis • To understand the impact of cytokines and stress on neuroendocrine systems

Research outcomes: • The discovery that a new molecule named kisspeptin plays a critical role within the brain in the control of ovulation

New Zealand Centre for Sustainable Cities

Director: Professor Philippa Howden-Chapman, Department of Public Health, University of Otago, Wellington

Website: http://sustainablecities.org.nz/

The New Zealand Centre for Sustainable Cities (CSC) was launched in February 2008. The Centre has been set up to further develop collaborative research that contributes to the sustainable development of our cities. Over 87 per cent of our population live in urban environments, so we face a challenge to keep our cities sustainable and competitively attractive in international terms, and the people within them healthy and socially connected.

The CSC builds on a strong existing network of expertise. It is a partnership, led by the University of Otago, of six universities (Otago, Canterbury, Victoria, Massey, Waikato and Auckland) and three Crown Research Institutes (Landcare, NIWA and BRANZ). It is positioned to work with regional councils, territorial local authorities and national agencies, with national frameworks that can accelerate urban sustainability.

The research group is inter-disciplinary, and includes social scientists, public health specialists, physicists, geographers, engineers, economists, sociologists and Mäori researchers.

The Centre is planning to develop an innovative set of linked programmes that explore key factors for developing policies for sustainable cities. This will include a programme of knowledge exchange and synthesis about urban sustainability initiatives, and research to improve stakeholders’ access to relevant knowledge. The appraisal and measurement tools developed will enable sustainability choices and consequences to be made more explicit across sectors and jurisdictions. Fundamentally, this will be a programme of conceptual and empirical research on strategic urban sustainability questions that will provide a focus for future research and policy development.

Major research goals: • To work in partnerships to develop the tools to promote well-being and health in our cities through smarter economic development, safer and more sustainable housing, transport and energy systems, and enhanced urban design. • To seek ways to support workforce development and increase the skills of those working on urban sustainability.

26 RESEARCH REPORT 2007/2008 New Zealand Pharmacovigilance Centre

Director: Dr Michael Tatley, Department of Preventive and Social Medicine, Dunedin School of Medicine

Website: http://carm.otago.ac.nz/

The New Zealand Pharmacovigilance Centre (NZPhvC) (previously CARM – Centre for Adverse Reactions Monitoring) was established for the purpose of monitoring adverse reactions to medicines, vaccines and other products marketed and used as therapeutics in New Zealand. The NZPhvC operates under contract to the Ministry of Health and provides services in support of a national adverse events and drug safety monitoring programme to Medsafe (New Zealand’s national medicines regulatory authority) and the Medicines Adverse Reactions Committee (MARC, a national advisory committee to the Minister of Health). The Centre regularly publishes its observations and analyses in the local and international literature. In addition to its own database analyses and research projects, the NZPhvC frequently collaborates with other researchers and projects. The NZPhvC is a participant in the World Health Organisation’s Programme for International Drug Monitoring which pools adverse reaction data globally from over 84 National Centres providing a powerful means of signal identification. The Centre’s expertise has been recognised by the WHO through the appointment of two of the NZPhvC’s staff to serve as consultants to support the international signal review process.

The NZPhvC’s initiatives now extend across 4 major areas: • Adverse reaction reporting • Intensive Medicines Monitoring Programme • Vaccine Monitoring Programme • Medication Safety

Adverse reaction reporting involves collecting and evaluating spontaneous reports of adverse reactions to medicines, vaccines, herbal products and dietary supplements from health professionals in New Zealand. The Intensive Medicines Monitoring Programme (IMMP) undertakes prospective, observational, cohort studies on selected new medicines. These are aimed at measuring the incidence of adverse reactions, their characterisation, the early identification of previously unrecognised reactions and the construction of a risk profile for each medicine.

The Vaccine Monitoring Programme was established to monitor recipients of the MeNZB vaccine during the 2004-2006 immunisation campaign for possible significant safety issues. It has, through this programme, established a methodology for community level monitoring of vaccines used in campaign or clinical trial mode.

The NZPhvC has recently embarked on a programme to monitor Medication Safety through the identification of preventable adverse events including the occurrence of medication error. Current initiatives involve the development of a model to monitor the nature and extent of these events at primary care level, whilst also investigating systems that can collate secondary and tertiary care relevant data which together will serve to inform improvements in prescribing practice and the safe use of medicines.

Ngai Tahu M-aori Health Research Centre

Director: Associate Professor John Broughton, Department of Preventive and Social Medicine, Dunedin School of Medicine

See below under the Mäori Health Research section.

Division of HEALTH SCIENCES 27 Sir John Walsh Institute for Oral Health

Director: Professor Gregory Seymour, Faculty of Dentistry

The Sir John Walsh Research Institute was established in 2007 in the Faculty of Dentistry. The mission of the Institute is to achieve better health for New Zealanders through improved oral health. The Institute aims to make an appreciable difference to the quality of life of a large proportion of New Zealand’s population, with the greatest benefit to the most disadvantaged. Improvements to health will be achieved through the delivery of improved services and the application of novel technologies to oral health problems. It is also intended that such improvements and innovations will also generate economic benefits for New Zealand.

Oral health is essential for well-being and poor oral health may also directly affect general health through the promotion of systemic disease. The direct and indirect financial and societal costs of oral disease are huge, but are ignored to a large extent in New Zealand, where there are significant challenges to the improvement of oral health. The country’s ageing population is retaining natural teeth for longer, with concomitant increases in dental caries and periodontal disease, and in the demand for advanced oral care in areas such as rehabilitation of the dentition, regeneration of periodontal tissues, and in oral disease prevention in medically compromised patients. Social and ethnic inequalities in oral health are also a serious problem.

An innovative, future-focused set of inter-connected research programmes in the Institute will address these significant barriers to achieving improved oral and general health. The University of Otago conducts the only oral health research in New Zealand and is ideally positioned to form a niche area of national importance.

Major research goal: • To improve the general health and well-being of New Zealanders by improving their oral health • To serve as a focus and advocate for oral health research and instil a research ethos in oral health throughout New Zealand

Webster Centre for Infectious Diseases

Director: Professor Kurt Krause: Department of Biochemistry, Otago School of Medical Sciences

Website: webstercentre.otago.ac.nz/webstercentremeeting.html

The Webster Centre for Infectious Diseases has as its mission the development of diagnostics, antimicrobials, and vaccines to address important problems caused by infectious diseases in New Zealand today. A worldwide resurgence in infectious diseases has created an environment in which new and emerging pathogens such as bird flu, SARS, and HIV are assuming prominence and pose a threat to people and also to native and domestic animals. There is a significant void in New Zealand’s front line of defence against infectious disease due to a reliance on acquiring therapies offshore. To address this issue, the Centre is bringing together a community of scientists with the expertise to develop new therapies against infectious diseases and rapidly respond to the threat of new pathogens. Research in the Centre is interdisciplinary involving biochemists and chemists, in collaboration with pharmacologists, microbiologists, immunologists, epidemiologists and clinicians.

Major research goals: The Webster Centre aims to create a collaborative environment that fosters interdisciplinary work between members, which will eventually lead to the Webster Centre being a focal point to direct, support and coordinate these activities. More specifically the aims of the Webster Centre are: • To translate progress in the laboratory to products that may be used to promote health. This will be done by encouraging research on developing diagnostics, vaccines, and antimicrobials in New Zealand, in order to reduce New Zealand’s dependence on offshore therapies. • To help coordinate multidisciplinary research on infectious diseases in New Zealand. This will be accomplished through regular Webster Centre sponsored research meetings at the University of Otago featuring both domestic and international researchers, through a monthly newsletter, which will be circulated to our membership, and through the creation of a Webster Centre website. • To help train scientists to conduct research into infectious diseases. This will be accomplished in part by providing opportunities to bright young scientists. This year we announced an Undergraduate Summer Research Scholarship valued at $5000 to give a second or third year student the opportunity to work in a research laboratory for the summer. Additionally, we will soon announce a Travel Scholarship for a Postgraduate student to attend a major international meeting.

28 RESEARCH REPORT 2007/2008 Research outcomes: • In April 2007, the first New Zealand wide Webster Centre for Infectious Diseases research meeting was held in Dunedin at which over 40 New Zealand based researchers attended and discussed their laboratory research. • In December 2007, the Webster Centre sponsored a symposium on computational biology at the University of Otago. This symposium featured three outstanding international speakers including J. Andrew McCammon, University of California, San Diego, USA along with one local speaker, Dr. Joel Tyndall, Lecturer, Pharmacy. • In November 2008, the Webster Centre helped to sponsor the Virology Theme research meeting held in Dunedin. Approximately 40 speakers were in attendance, with representatives from New Zealand, Australia, the United States and Europe.

Women’s Health Research Centre

Director: Dr Beverley Lawton, Department of Primary Health Care and General Practice, University of Otago Wellington

Website: www.wnmeds.ac.nz/academic/gp/whrc/index.html

It is essential for New Zealand to have a dedicated women’s health research unit. It is no secret that women and men are different - especially when it comes to health. There are many health conditions that mainly affect women, and other conditions that affect women differently than men. Issues like menopause and maternal health affect only women. Others like contraception and fertility affect women differently than men, and some diseases like osteoporosis and Alzheimer’s affect more women than men. For many years, results gained from medical research involving men have been extrapolated to fit women, despite that fact that the two sexes are physiologically different. In the past decade, research has proven that such differences affect the prevalence and severity of a broad range of diseases, disorders, and conditions, as well as affecting their prevention, diagnosis and treatment.

The Women’s Health Research Centre (WHRC) emphasises research aimed at minimising disability and chronic diseases in women as they age. It also focuses on the health of children and families. Key areas of research focus include mid-life health, including hormone replacement therapy, menopause and uterine cancer; prevention of diabetes and heart disease; and sexual reproductive health including sexually transmitted infections and maternity. The WHRC is also interested in research relating to osteoporosis, contraception, fertility, unplanned pregnancy, and maternity and health of the newborn.

The vision of the centre is to be the centre of excellence for women’s health research in New Zealand. Its major research goals are listed below.

Major research goals: • To undertake research that impacts positively on the health and well-being of women • To be advocates for women’s health research both nationally and internationally • To promote research findings relevant to women and families e.g. evidence based knowledge about antenatal testing, HPV vaccine etc

Research outcomes: • The Centre was awarded an HRC grant of approximately $700,000 to investigate inequalities in uterine cancer diagnosis between Mäori and non-Mäori women. • The Women’s Lifestyle Study has had ongoing contact with 3500 women aged 49 and older since 1999, in studies including hormone replacement therapy, menopausal symptoms, bladder health, healthcare utilisation and general health and well- being. Findings have been published widely. • It has been found that the increasingly common sexually transmitted infection Chlamydia can be controlled by encouraging women to self-test for the infection.

Brain Health and Repair Research Centre

Director: Professor Cliff Abraham, Department of Psychology, University of Otago

Website: http://psy.otago.ac.nz/staff/abraham.html

Although this Centre is not led by a member of the Health Sciences Division, Divisional staff have significant input into the Centre. Please refer to the website above for further information.

Division of HEALTH SCIENCES 29 - - RANGAHAU HAUROA MAORI – MAORI HEALTH RESEARCH

Mäori health research is conducted across all the Schools of the Division. Research includes Mäori mental health, Mäori cardiovascular health, medical education in Hauora Mäori, inequalities in health and the reasons for it, indigenous health workforce issues, Mäori oral health, gout, diabetes, physical activity and Mäori medicines and use of medicines.

In 2008, the Faculty of Medicine appointed a Director Hauroa Mäori at each of its major campuses to provide overall leadership of Mäori academic development. The Directors are Dr Jo Baxter (Dunedin), Suzanne Pitama (OUC) and Bridget Robson (OUW). Each of the Division’s campuses houses a distinct Mäori research unit:

Te Rop- u- Rangahau Hauora Maori- o Ngai- Tahu - Ngai- Tahu Maori- Health Research Centre, DSM

The Ngai Tahu Mäori Health Research Unit was established in 1996 as a partnership between Te Runanga o Ngai Tahu and the Dunedin School of Medicine at the University of Otago. Over the ensuing years the Unit has engaged in a number of Mäori health research projects that have been aligned to the aspirations of not only Ngäi Tahu but iwi Mäori katoa (all Mäori). The overarching theme has been whänau ora or the health and well-being of the family.

The Unit has collaborative research projects with the Injury Prevention Research Unit and the Dunedin Multidisciplinary Health and Development Research Unit. The Unit also assists other research groups with aspects of Mäori health research that may be part of their respective projects.

Major research goals: • To undertake and disseminate research in areas of recognised high Mäori health need in order to contribute to improved Mäori health outcomes e.g. Mäori mental health, Mäori oral health, Mäori health and disability. • To undertake collaborative partnership research with a number of research groups (Injury Prevention research unit, Dunedin Multidisciplinary Health and Development Research Unit) and responsive research to meet the needs of Mäori communities. • To build up the Mäori Health Research Workforce in experience, skills and in number.

Research outcomes: • Dr Joanne Baxter has produced a Mäori mental health needs profile providing a review and analysis of Mäori mental health research and outcomes for use by the Ministry of Health and the New Zealand Mental Health sector. This document was used to inform the most recent Mäori mental health strategy document from the Ministry of Health. • Since 2000, Associate Professor John Broughton has undertaken a clinical attachment for final year dental students with the Tipu Ora Charitable Trust, a Mäori health provider based at the Tunohopu Marae, Ohinemutu, Rotorua. In July 2007, a Memorandum of Agreement was signed between Tipu Ora and the University of Otago to formalise and enhance this relationship. A research survey is being planned to investigate the value of community-based learning experiences of the dental students.

Maori- and Indigenous Health Institute (MIHI), OUC

MIHI has had extensive experience in researching within Mäori communities. The Institute conducts research that assists with an understanding of Mäori health and works to develop strategies that promote Mäori health gain. MIHI also has significant input into the medical curriculum. The Institute’s activities include: • Contributing to the development and implementation of the undergraduate medical curriculum • Supervision and mentoring of Mäori researchers and non-Mäori undertaking research alongside Mäori participants (this includes summer studentships, dissertations and theses). • Undertaking Mäori-focussed research, both university and community based • Collaborating with other groups and Departments within the School to develop and implement research • Working to support Iwi research development • Working with Mäori colleagues from other university-based health centres in research and teaching • Contributing to national Mäori health networks • Contributing to local and national health committees and working groups • International collaboration with indigenous health organisations from other countries

30 RESEARCH REPORT 2007/2008 The Institutes research interests include: the undergraduate medical curriculum; resilient indigenous health workforce networks; quality and health outcomes for Mäori; addiction and Mäori health; and cardiac disease in Mäori. An important ongoing study is the Mäori Community Heart Study. This is a collaborative study with the Christchurch Cardioendocrine Research Group and is investigating the full range of cardiac risk factors for Mäori within two community settings. There is a major disparity between Mäori and non-Mäori in cardiovascular mortality and yet there are few studies on the prevalence and incidence of cardiovascular disease in the Mäori community. The project will also identify objective markers (biochemical and cardiac imaging) for monitoring cardiovascular disease risk in Mäori, and will document the implementation of treatment programmes, interventions, barriers to care and outcomes for study participants. For further information see www.chmeds. ac.nz/research/chs/index.htm

Website: www.chmeds.ac.nz/departments/mihi/index.htm

Te Ropu Rangahau Hauroa a Eru Pomare – Eru Pomare Maori- Health Research Unit, OUW

Te Röpü Rangahau Hauora a Eru Pömare strives to create a Kaupapa Mäori space committed to improving Mäori health outcomes and eliminating inequalities through quality science and ongoing theoretical development. It takes a rights-based approach consistent with the Treaty of Waitangi, and is engaged with community through a spectrum of influence from community development, policy advocacy, research dissemination and Mäori health.

Website: www.wnmeds.ac.nz/academic/dph/research/erupomare.html

Mäori Community Heart Study researchers Associate Professor Vicky Cameron and Suzanne Pitama from the UOC

Division of HEALTH SCIENCES 31 FACULTY OF DENTISTRY

DEPARTMENT OF ORAL DIAGNOSTIC AND SURGICAL SCIENCES

Head of Department: Professor Robert Love. Email: [email protected]

The Department of Oral Diagnostic and Surgical Sciences is organised into the disciplines of Oral and Maxillofacial Surgery, Oral Medicine, Oral Radiography, Oral Pathology, Special Needs Dentistry, Clinical Pharmacology and Sedation, and General Dental Practice. The main areas of research in the department are: • oral diseases and healing with particular interest in human and experimental epithelial hyperplasia, preneoplasia DENTISTRY and neoplasia • endodontic microbiology and the molecular mechanisms involved in bacterial invasion of dentine • the development of endodontic medicaments for root canal disinfection and their effects on bacteria and tissues culture • clinical research in endodontics, dental implantology, oral and maxillofacial surgery, trauma, and prosthodontics.

Website: http://dentistry.otago.ac.nz/departments/odss.html

Major Areas of Research Strength

Endodontic microbiology The study and practice of endodontics is aimed at preventing and treating pulp and periapical disease. An understanding of the mechanisms of bacterial invasion of dentine and the root canal system is central to these aims. Bacterial infection of dentine has been recognised for over a century, but only recently has this research group identified the mechanisms involved in colonisation. An understanding of these mechanisms should lead to novel prophylactic and control treatments. Recent endodontic microbiological research has focused on the effect of nutritional stress on bacterial invasion of dentine, and identified that colonisation of dentinal tubules is dependent on an ideal nutritional environment, with nutritionally stressed bacterial cells losing their ability to invade.

Oral and maxillofacial surgery The discipline of Oral and Maxillofacial Surgery has a strong clinical research focus and is involved with collaborative research within the department, Faculty and outside of the School of Dentistry. Particular areas of research interest include epidemiological studies of maxillofacial injuries, oral and maxillofacial pathology and general practitioner experiences in dealing with maxillofacial trauma. Clinical trials involving patients are also part of a wider research focus and current studies continue to progress which include third molar surgery, post-operative analgesics and dental implantology. A series of evidence based systematic reviews of selected aspects of maxillofacial trauma management is being developed. Local expertise in ballistic and war injuries to the maxillofacial region also exists in the department.

Oral pathology Research interests in oral pathology involve immunohistochemical and PCR studies looking at the expression of various inflammatory processes in oral inflammatory lesions (e.g. periapical pathology, mucosal lichen planus) and oral malignancy (squamous cell carcinoma) in order to better understand the pathological processes involved. Investigation of expression of putative odontogenic-specific markers in odontogenic tumours and cysts is another research thread. We have recently begun a collaborative study with other groups within the University exploring the use of saliva as a diagnostic medium for the detection of human papilloma viruses. Epidemiological studies on pathology of the soft and hard tissues of the oral cavity and related structures show that the prevalence and distribution of oral pathological lesions in the New Zealand population is comparable to similar developed countries.

32 RESEARCH REPORT 2007/2008 External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P Alison Rich Does Performance in Selection Processes OU Research into $14,629 Predict Performance as a Dental Student? Teaching Grant

2008 Suraya Sinon Expression of toll-like receptor 2 (TLR-2) in NZDA Research $10,900 oral mucosal lichen planus using Foundation

immunohistochemistry and quantitative DENTISTRY real-time reverse transcriptase polymerase chain reaction (qRT2-PCR)

2008 Haizal Hussaini Expression of pro-inflammatory cytokines and NZDA Research $9,321 distribution of immune cell in oral squamous Foundation cell carcinoma

2008 Lara Friedlander Stem cells in the apical region of immature NZDA Research $7,500 permanent teeth from humans and deer Foundation

2007 Darryl Tong Oral and Maxillofacial Trauma and the general NZDA Research $9,900 practitioner Foundation

Total $52,250 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 2 3 Masters† 9 14

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Jessica Buchanan School of Dentistry Clinical Excellence Day – Best Student Presenter Award for Presentation “Temporomandibular Joint Replacement”

Division of HEALTH SCIENCES 33 DEPARTMENT OF ORAL REHABILITATION

Head of Department: Mr David Purton. Email: [email protected]

Research undertaken within the Department of Oral Rehabilitation covers a diverse range of topics related to clinical cariology, endodontics, biomaterials, prosthodontics and dental technology. More specifically, research is directed at the prevention and treatment of dental disease, the repair and replacement of teeth and their associate structures affected by disease, trauma or wear, the restoration of form, function and appearance, mechanical testing and computer modelling of the behaviour of dental tissues and biomaterials.

DENTISTRY Website: http://dentistry.otago.ac.nz/departments/oralrehabilitation.html

Major Areas of Research Strength

Biomaterials and biomechanics Investigations focus on a range of mechanically mediated responses of dental materials and biological tissues, ranging from the influence of mechanical forces on the stresses developed in the mandible to the stresses and failure mechanics of restorations. This research has significant bearing on the design longevity and anticipated failure of implant-supported structures. Major inroads have been made into the understanding of the stresses developed in craniofacial structures as a consequence of biting forces. The use of CT-based images and computer modelling has enabled researchers to predict the mechanics of failure of complex dental restorative systems. This will lead to a more rational design and selection of materials for tooth restorations. Research is in collaboration with the Department of Oral Sciences.

Oral implantology Clinical and laboratory-based research relating to implant dentures and single-tooth implants is conducted. The aim is to improve the oral health-related quality of life of the ageing population. The Department’s evidence-based treatment approach of reducing the delay between oral implant placement and loading with the prosthesis is internationally recognised. Current projects include a multicentre study on mandibular implant partial dentures, a randomised controlled clinical trial on conventional and immediate loading of single implant crowns, evaluation of different occlusal schemes of implant overdentures, photo-elastic studies on oral implants supporting partial dentures, and investigations into different ceramic systems for single-implant crowns.

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Mrs Lara Friedlander Stem cells in the apical region of immature NZ Dental 7,500 permanent teeth from human and deer Research Foundation Projec

2007 A/P Nicholas Chandler The infected resected root end: effect of NZ Dental 6,645 disinfectants and lasers on infected dentinal Research Foundation tubules, the smear layer and root-end seals

2007 Dr Richard Cook The effects of different embedding resins, tissue NZ Dental 3,113 storage methods and indentation protocols on Research Foundation the nanoindentation of Ovine bone tissue Project

2007 Miss Artika Patel The apicectomy operation Dentsply Research 2,235 Fund Project

Total $19,493

Total for all grants active in 2007-8 but awarded prior to 2007 $191,188

Grand total $210,681 * GST exclusive

34 RESEARCH REPORT 2007/2008 Postgraduate Students

Total Head Count* 2007 2008

PhD 7 8 Masters† 2 3

* as at 1 June each year † thesis or dissertation students only DENTISTRY DEPARTMENT OF ORAL SCIENCES

Head of Department: Professor Jules Kieser. Email: [email protected]

The major research interests of the Department of Oral Sciences are cell biology, community oral health, education in dentistry, molecular oral microbiology, orthodontics and periodontics, craniofacial biology, dental epidemiology and public health, oral implantology, and immunopathology. The Department has a Molecular Microbiology Laboratory and research staff and students contribute to the University of Otago Oral Microbiology and Dental Health Research Theme.

Website: http://dentistry.otago.ac.nz/departments/oralsciences.html

Major Areas of Research Strength

Dental epidemiology and public health The Dental Epidemiology and Public Health group investigates the oral health of populations, with particular attention given to the natural history of dental disease and health through childhood, adolescence and adulthood. Collaborations with two world-renowned projects are ongoing - the Dunedin Multidisciplinary Health and Development Study (a prospective observational study of a cohort of New Zealanders born in 1972-73) and the South Australian Dental Longitudinal Study (a prospective observational study of a cohort of older South Australians).

The Group also investigates the way in which dental health services work, how people use them, and what can be done to improve the delivery of oral health care. Our group has played an important role in the development and epidemiological validation of new measures for child oral health-related quality of life, working in collaboration with a number of overseas researchers.

Oral microbiology Microorganisms contribute to, or are responsible for, many oral diseases, including dental caries, gingivitis, periodontitis and oral candidosis. Research in the Molecular Microbiology Laboratory uses molecular genetic, microbiological, and biochemical techniques to investigate microbial physiology, adhesion, colonisation, pathogenicity and drug resistance, with the aim of discovering how oral microorganisms cause disease and become resistant to current drugs. Other research projects include examining the microbial diversity of the oral cavity (metagenomics) and sequencing of oral bacterial genomes using high- throughput DNA sequencing strategies in combination with bioinformatic software tools. This information allows researchers to devise new ways of preventing oral (and many other) microbial diseases. Researchers in the laboratory have developed novel genetic and biochemical systems to study drug resistance and to screen for new drugs. These systems have wide applications across the dental, medical, and biological sciences.

Forensic dentistry There is an active research programme in forensic science in the Department. Areas of research interest include: the biomechanics of wounding; marine decomposition; and bite marks and personal identification. A key recent project has involved the bacteriological fingerprinting of bite marks, where the unique streptococci bacteria transferred by a bite may be used to identify offenders in sex crimes or child abuse. Another project of note is the development of various models which reliably replicate blunt trauma impact events.

A new interdivisional research project has been launched which is aimed at the admissibility of expert forensic evidence. The team consists of dental researchers and others from the Faculty of Law, the School of Pharmacy, and the Dunedin School of Medicine.

Division of HEALTH SCIENCES 35 Immunopathology The Immunopathology Research Group is a multidisciplinary group involving staff and students from all three departments within the School of Dentistry. The major focus of the group centres around the immunopathology and immunoregulation of oral diseases including periodontal disease, oral mucosal disease, oral cancer and diseases of endodontic origin. In addition, the expertise of the group is being used to study wound healing in a sheep model and the biology of periapical stem cells. The second major focus of the group is in identifying gene expression profiles using quantitative RT-PCR focused gene arrays. This technology is being used to determine both the peripheral blood and salivary transcriptomes in periodontal disease, to determine gene expression by Porphyromonas gingivalis-stimulated lymphocytes in cardiovascular patients and to study the influence of smoking and bisphosphonates using an in vitro wound healing model. Finally, the group is interested in developing salivary diagnostics for human papilloma virus oral disease and the use of metagenomics to determine the oral

DENTISTRY microbiota associated with periodontal disease and early childhood caries.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Richard Cannon Fungal transporters: from resistance to new National Institutes 343,446 antifungals of Health

2008 Ms Kate Morgaine Pilot intervention study to improve the oral HRC Project Grant 100,000 health of rangatahi in Taranaki

2008 Dr Geoffrey Tompkins Immune milk to prevent tooth decay AgResearch University 60,000 of Otago Collaborative Research Fund

2007 Prof Richard Cannon Human membrane protein expression system. FRST International 1,560,001 A novel protein expression system for human Investment membrane protein analysis and drug discovery Opportunities Fund

2007 Prof Murray Thomson Administrative supplement to Oral health National Institute for 175,000 disparities in the first 4 decades of life. Dental and Craniofacial Research, NIH

2007 Prof Richard Cannon Ultraspeed centrifugation for Dental and Lottery Health Research 79,000 Medical Research

2007 Prof Richard Cannon Aspergillosis: overcoming drug resistance of an Japan Health Sciences 55,556 important human fungal pathogen Foundation

Total $2,373,003

Total for all grants ≤ $50,000 awarded in 2007-8 $157,943

Total for all grants active in 2007-8 but awarded prior to 2007 $3,225,865

Grand total $5,756,811 * GST exclusive

36 RESEARCH REPORT 2007/2008 Postgraduate Students

Total Head Count* 2007 2008

PhD 12 14 Masters† 5 6

* as at 1 June each year † thesis or dissertation students only DENTISTRY Awards and Scholarships

Year Researcher Award/Scholarship

2008 Prof Jules Kieser Alan Docking Award from the International Association for Dental Research

Professor Murray Thomson a member of the Dental Epidemiology and Public Health Group

Division of HEALTH SCIENCES 37 FACULTY OF MEDICINE

OTAGO SCHOOL OF MEDICAL SCIENCES

DEPARTMENT OF ANATOMY AND STRUCTURAL BIOLOGY

Head of Department: Associate Professor Dorothy Oorschot. Email: [email protected]

Research activity within the Department of Anatomy and Structural Biology covers a wide range of topics including: neuroscience, reproductive biology, developmental biology, functional anatomy, biological anthropology, and cell biology. OSMS

The Department boasts a number of first-rate research facilities including two gene sequencers, light microscopy facilities (including a laser capture micro-dissection system and a Zeiss inverted microscope), X-ray and ultrasound, dedicated image analysis suites, a plastination laboratory, and an extensive human skeletal remains collection. The Department also houses the Otago Centres for Electron Microscopy and Confocal Microscopy.

Website: http://anatomy.otago.ac.nz/

Major Areas of Research Strength

Preimplantation embryo research Research is focused on developing diagnostic tools for evaluating the quality of human pre-implantation embryos. To this end, the work has two principal objectives: (i) obtaining a molecular understanding of pre-implantation development and the molecular phenotypes of eggs, pre-implantation embryos, and follicles, and (ii) extending gene expression profiling to single cells, for application to evaluation of pre-implantation embryos.

Basal ganglia research Research covers a variety of areas including reward-related learning and memory mechanisms, neurodegenerative disorders, and structure and function of the normal or hypoxic basal ganglia. Researchers have demonstrated that activation of dopamine cells by rewards not only promotes the learning of behaviour but also strengthens synaptic connections in the striatum involved in bringing about the behaviour. This study was the first to link the dopamine system and learning directly with synaptic strengthening, and was published in Nature10.

The function of cholinergic brain cells has also been successfully documented, providing valuable information on how these cells are controlled during normal learning and in disease states. A key new project is developing technology that delivers bioactive chemicals to the brain in a manner that mimics natural patterns of release. The approach aims to provide optimised treatment for neurodegenerative disorders such as Parkinson’s Disease. In addition, various treatment strategies are being investigated to determine whether striatal neurons and motor skills can be rescued following hypoxic insults. An immature rat model of ADHD-like hyperactivity due to repeated hypoxia during the equivalent of extreme prematurity has also been developed and extensively characterised, in the hope of developing new treatments.

Sexual differentiation of the brain Men and women are differentially affected by most neurological diseases. Males are more likely to develop ADHD and motor neuron disease whereas anorexia nervosa is associated more with females. This group has found that a hormone active in the development of the sex organs in the male embryo, Mullerian inhibiting substance (MIS), is also present in the brain, creating a sex difference there too. MIS produces subtle differences in both the size and number of motor neurons between the two sexes, potentially explaining why men are more susceptible to motor neuron disease than females. Ongoing research will investigate how MIS also regulates other parts of the brain. It is hoped that this research could, in time, contribute to more effective treatments for some neurological disorders.

Neuroendocrine control of reproduction Research focuses on the neuroendocrine functions of the hormone prolactin, and in particular, the role of prolactin in the neuroendocrine and neurobiological adaptations of the maternal brain. Specific interests include the control of appetite and body weight during pregnancy and obesity, plasticity in oxytocin neurons during late pregnancy and lactation, and the role of prolactin in changes in mood and behaviour in the post partum period. The link between nutrition and fertility is also being investigated. The neural pathways by which the hormones leptin, insulin and ghrelin modulate GnRH neurons (the central drivers of fertility) in order to respond to the animal’s nutritional status are being studied.

10 Reynolds JN, Hyland BI, Wickens JR. (2001). A cellular mechanism of reward-related learning. Nature. 413(6851):67-70.

38 RESEARCH REPORT 2007/2008 Clinical anatomy There is an active research programme in clinical anatomy in the department. Particular emphasis is placed on issues relevant to surgical and physiotherapy practice. Current areas of research include: the clinical anatomy of vascular structures, deep fasciae, the musculoskeletal system, and the head and neck region. Investigations into the morphological factors that contribute to dysphagia (difficulty swallowing) are also ongoing. Three-dimensional reconstruction in clinical anatomy is another strength, with studies focusing on the junction between the pancreatic duct and bile duct. A variety of techniques are utilised including: gross dissection, microdissection, E12 sheet plastination, SEM, TEM, confocal microscopy, corrosion casting; and MRV and Digital Subtracted Angiography.

Other research

The Department of Anatomy and Structural Biology is a very research-intensive department and has a number of other DENTISTRY areas of research strength including: alcohol and brain development; bioethics; biological anthropology; schizophrenia; development of bone graft substitutes and composite surgical appliances; reproduction and genomics; functional anatomy; developmental biology of skeletal muscle; and molecular mechanisms of learning and memory in the hippocampus.

Professor Helen Nicholson whose research interests include reproductive processes in the male and clinical anatomy

Division of HEALTH SCIENCES 39 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof David Green Tricorders – Handheld diagnostic devices Research project – 8,826,668 FRST

2008 A/P David Grattan Hypothalamic role of inter-leukin-18 in energy Auckland University 830,007 and glucose homeostasis Subcontract OSMS 2008 A/P David Grattan Regulation of maternal body weight and glucose Auckland University 823,970 homeostasis during pregnancy Subcontract

2008 A/P Neil Gemmell Simple sequences don’t evolve simply: what is the Marsden Fund Project 683,556 role of recombination in microsatellite evolution?

2008 A/P Ian McLennan Is boyhood shaped by MIS? Marsden Fund Project 647,111

2008 Dr George Dias Novel implants for spinal fusion University of Canterbury, 396,200 FRST

2008 Dr Koreen Clements Is synaptic plasticity in the striatum dependent Natural Sciences & 98,068 upon dopamine receptor expression Engineering Research Council Canada Fellowship

2008 Dr Beulah Leitch Determining the location of CaV1.3 L-type Okinawa Institute of 67,790 calcium channels on striatal membranes Science and Technology

2008 A/P David Grattan, Hormonal mechanisms causing post HS & JC Anderson 50,544 Dr C Larsen partum anxiety

2007 Prof Jeffery Wickens Cellular mechanisms of behavioural hyperactivity HRC – Project 1,158,739 in the brain (extension)

2007 A/P Ian McLennan Therapies for age-related deterioration – Research project – 855,565 Drugs for aging FRST

2007 Prof David Green ART and Stem Cell Markers New Economy 316,417 Research Fund

2007 Dr Manfred Oswald Controlling acetylcholine in the brain – a NZ Neurological 171,789 therapeutic target for Parkinson’s disease? Foundation Project

2007 Dr George Dias Development and characterisation of novel AgResearch/OU 80,000 hybrid absorbable sutures Collaborative Research Fund 2007 Dr Caroline Larsen Mechanisms of postpartum anxiety Lottery General Project 70,569

Total $15,076,993

Total for all grants ≤ $50,000 awarded in 2007-8 $226,356

Total for all grants active in 2007-8 but awarded prior to 2007 $13,001,108

Grand Total $28,304,457 * GST exclusive

40 RESEARCH REPORT 2007/2008 Research Contracts

Year Approved Organisation

2007-2008 Landcare Paua Industry Council Limited (PICL) Lanzatech NIWA AgResearch Fonterra Research Centre Ltd

New Zealand Forest Research Institute Ltd OSMS Otago Innovation Limited Keratec Ltd Massey University University of Queensland Monash University NZ Institutue of Crop & Food Research University of Auckland University of Canterbury

Total $2,196,694

Postgraduate Students

Total Head Count* 2007 2008

PhD 29 30 Masters† 23 19

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr John Reynolds National Tertiary Teaching Excellence Award

2008 A/P Dave Grattan Invited to be Editor-in-Chief for the Journal of Neuroendocrinology

2008 Chris Smith QEII Technician’s study award

2008 Ana Claasen TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

2007 Dr Robert Miller Officer of the New Zealand Order of Merit

2007 Rosemary Geddes TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

Division of HEALTH SCIENCES 41 DEPARTMENT OF BIOCHEMISTRY

Head of Department: Associate Professor John Cutfield. Email: [email protected]

Research in the Department is largely concerned with fundamental processes associated with a number of significant biomedical and biological problems: heart disease; cancer; diabetes, rheumatoid arthritis and gout; memory and neurological disease; pathogenic viruses, micro-organisms and fungi; flowering, senescence, photosynthesis, nitrogen utilization in plants, symbiosis; mammalian preimplantation, embryo development; cold adaptation; eukaryotic retroelements; body weight and cell signalling; molecular evolution; apoptosis; biodiversity. Extensive use is made of bioinformatics, microarray technology and proteomics tools. The Otago Genomics Facility, the Centre for Protein Research and the X-ray facility for protein

OSMS structure determination are all located within the Department.

Website: http://biochem.otago.ac.nz/

Major Areas of Research Strength

Cancer genetics The Cancer Genetics Laboratory is the hub for cancer genetics research within the department. Research interests are fourfold: Wilm’s tumour and genomic imprinting; stomach cancer; colorectal cancer; and leukaemia. The overall aim of the research is to elucidate the genetic events leading to cancer, in order to improve diagnostic methods and assist in the design of better therapies. The CGL has identified genetic and epigenetic mechanisms involved in the onset of Wilm’s tumour, which develops in the kidneys of young children. Research is underway investigating the nature of the environmental and genomic factors involved in childhood acute lymphoblastic leukaemia, with a particular emphasis on epigenetic mechanisms. Several projects have led to the discovery of genomic profiles which may aid in prognostic assessment of patients with colorectal cancer. Another project is concentrating on identifying the causes of stomach cancer, with an emphasis on the inherited form of the disease. A defective gene leading to familial stomach cancer was identified which enabled the screening of high risk families to identify carriers who then undergo surveillance for early cancer detection. Major funding for the Cancer Genetics Laboratory is from an HRC programme grant entitled ‘Epigenetics and Genetics of Cancer’.

Website: http://cancer.otago.ac.nz/

Memory and Alzheimer’s disease A long-standing interest in the department has been the molecular mechanisms of mammalian memory and how they are impaired in human neurological diseases. Investigations have focused on the molecular changes in neurons of the hippocampus when they receive a processed brain protein (secreted amyloid precursor protein) that we have produced in the laboratory as a recombinant molecule. Simple production and purification strategies have been developed for this protein, and for the peptide β amyloid, the major component of plaques found in the brains of sufferers of Alzheimer’s disease. Remarkably, the recombinant secreted amyloid precursor protein can alone restore memory mechanisms in rats where the endogenous pathway for its production has been blocked by drug intervention, and as well as restoring memory of spatial learning tasks to these animals.

Structural biology of infectious diseases There is a worldwide resurgence in infectious diseases which pose a threat to our population and to our native and domestic animals. Researchers are seeking to develop diagnostics, antimicrobials and vaccines to address important problems caused by such diseases. The molecular structures of proteins inside infectious viruses and microbes are being probed to seek out weaknesses that can be exploited. New drugs to combat these diseases can then be designed. Specific disease targets are tuberculosis, HIV/AIDS, streptococcal disease, poxviruses, Candida and MRSA. Research efforts have been bolstered by the recent creation of the Webster Centre for Infectious Diseases and by the establishment of a high-flux protein crystallography laboratory in the Department.

Autoimmune diseases Research focuses on the underlying genetics of gout and rheumatoid arthritis, two common forms of arthritis. Large databases of DNA obtained from sufferers of autoimmune diseases are being used to identify causative genes. Researchers have confirmed that the gene PTPN22 is one of the factors that causes rheumatoid arthritis, only the second gene in the past 25 years to be universally accepted as a causative factor. The group has also developed a new microarray technology which has allowed a genome-wide scan to simultaneously test all genes for association with rheumatoid arthritis. This technology is being applied to other chronic conditions in order to uncover their pathogenesis, including abdominal aortic aneurysm, schizophrenia, gout and inflammatory bowel disease.

42 RESEARCH REPORT 2007/2008 Other research The Department of Biochemistry is a very research-intensive department and has a number of other areas of research strength including: bioinformatics, bacterial molecular biology; evolution and development; plant biochemistry; proteomics; and heart disease. Many of these project areas are funded by the HRC, FRST or Marsden grants.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Organisation Total $ Approved Investigator Approved* OSMS 2008 Dr Tony Merriman Genetics of gout in Aotearoa HRC Project 1,361,458

2008 Prof Warren Tate How does secreted amyloid precursor protein Marsden Fund Project 868,000 enhance memory mechanisms

2008 Dr Liz Ledgerwood Defining tissue specific thresholds for apoptosis; Marsden Fund Project 818,000 new insights from the first mutation in cytochrome c

2008 Dr Catherine Day Bridging the 50 A ubiquitin gap Marsden Fund Project 815,000

2008 A/P Julian Eaton-Rye Shedding light on membrane protein biogenesis Marsden Fund Project 810,000 and repair in oxygenic photosynthesis

2008 Dr Richard Macknight Merinet research programme -customised AgResearch, FRST 403,029 flowering

2008 Dr Tony Merriman The GRIK2 gene: a link between rheumatoid HRC – Project 371,234 arthritis and schizophrenia?

2008 Dr Jade Hollis-Moffatt Understanding the genetic basis of hyperuricemia HRC Emerging in Te Tairawhiti, NZ Researcher First Grant 334,469

2008 Ms Tina Summerfield Harnessing the potential of New Zealand NZ Science & Technology 251,332 cyanobacteria as a renewable energy source Postdoctoral Fellowship

2008 A/P Iain Lamont Unravelling P aeruginosa iron acquisition University of Tasmania 155,679 mechanisms in vivo: Novel insights and potential therapies

2008 A/P Sally McCormick Using an old antibiotic to lower lipoprotein (a) National Heart 130,001 Foundation Project

2008 Dr Stephanie Hughes Capturing Time – a cell culture based time-lapse Lottery Health Research 125,848 imaging system

2008 Dr Stephanie Hughes Directing neurogenesis Marsden Fund Project 90,392

2008 A/P Julian Eaton-Rye Hypoxia adaptation and signalling in the Dos Lottery General Project 83,844 systems of Mycobacterium tuberculosis and Escherichia coli

2008 Prof Ian Morison National Research Centre for Growth and National Research 72,139 Development – Environment and Epigenetics Centre for Growth and Development

2008 Dr Bostjan Humar Genetic mechanisms underlying the progression HS & JC Anderson 51,219 of diffuse gastric cancer beyond the gastric mucosa

2007 Prof Warren Tate Mechanisms of secreted amyloid precursor HRC – Project 1,024,344 protein regulation of synaptic plasticity

Division of HEALTH SCIENCES 43 2007 Dr Tony Merriman The GRIK2 gene: a link between rheumatoid HRC – Project 902,896 arthritis and schizophrenia?

2007 Prof Kurt Krause Enhancing innate immunity to HIV HRC – Project 735,962

2007 Dr Peter Dearden The Molecular Basis of Royalty Marsden Fund Project 695,113

2007 Dr Richard Macknight Identification and characterisation of imprinted Marsden Fund Project 639,998 genes in plants

OSMS 2007 Prof Warren Tate A structural basis for decoding mRNA stop Marsden Fund Project 625,781 signals and mediating polypeptide release in protein synthesis

2007 Prof Ian Morison MTHFR Gene Polymorphisms and Epigenetic National Research 529,007 regulation Centre for Growth and Development

2007 Dr Elizabeth Poole A human gene using an expression strategy of Marsden Fund Project 565,334 HIV-1: function and implications for antiviral therapy

2007 Dr Chris Brown Integrated genomics resources for health and KAREN Working Group 416,210 disease & Development Fund

2007 Dr Jade Hollis-Moffatt Understanding the genetic bases of National Heart 180,000 hyperuricaemia, a pathophysiology involved in Foundation Training cardiovascular disease Fellowship

2007 Dr Megan Wilson The maternal blueprint: discovering novel Marsden Fund Project 151,114 patterning mechanisms in the Honeybee oocyte

2007 A/P Russell Poulter Mobile elements, strain recognition and sex in Lottery General Project 101,201 pathogenic Aspergillus fumigatus

2007 Dr Elizabeth Controlling inflammation by blocking free radical Lottery General Project 97,871 Ledgerwood production

2007 A/P Russell Poulter Curing frogs of fungal chytrid disease Lottery Environment 95,526 and Heritage

2007 Dr Susan Cutfield Recombinant production of ovine growth factors AgResearch Uni of 93,793 associated with reproduction Otago Collaborative Research Fund

2007 Dr Richard Macknight Comparative genetics of flowering in legumes AGMARDT Postdoctoral 78,223 Fellowship

2007 Dr Marion Maw Does a calcium channel gene on the NZ Neurological 66,084 X-chromosome confer susceptibility to autism? Foundation Project

Total $13,740,101

Total for all grants ≤ $50,000 awarded in 2007-8 $354,147

Total for all grants active in 2007-8 but awarded prior to 2007 $15,990,814

Grand total $30,085062 * GST exclusive

44 RESEARCH REPORT 2007/2008 Research Contracts

Year Approved Organisation

2007-2008 University of Auckland AgResearch Replicor Inc Lincoln University NIWA Department of Conservation OSMS Total $274,660

Postgraduate Students

Total Head Count* 2007 2008

PhD 43 38 Masters† 16 20

* as at 1 June each year † thesis or dissertation students only and includes MSc (BIOC), MSc (GENE) and MSc (PLBI) students

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr Mik Black Otago University Early Career Award for Distinction in Research

2008 Dr Tina Summerfield FRST Postdoctoral Fellowship

2008 Dr Tina Summerfield New Zealand Society of Plant Biologist’s ‘Roger Slack Award’ for Excellence in Research over the past 5 years

2008 Anna Konings TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

2008 Dr Tony Zaharic Voted one of Otago University Students Association’s top 10 lecturers

2008 Gemma Dickson TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

2007 Dr Peter Dearden University of Otago’s Rowheath Trust Award and Carl Smith Medal

2007 Dr Peter Dearden Invitrogen Life Science Award

2007 Dr Tony Zaharic Voted Otago University Students Association top lecturer

Division of HEALTH SCIENCES 45 DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Head of Department: Professor Frank Griffin. Email: [email protected]

The main research interests of staff in the Department of Microbiology and Immunology lie in the areas of agricultural microbiology, biotechnology, clinical microbiology and infectious diseases, microbial genetics, immunology, bacteriophage molecular biology, innate immunity and vaccine technology. Research is carried out in the following key areas: antibiotic resistance in bacteria, clostridial genetics, dendritic cells and their function, environmental microbiology and bioremediation, insect viruses and the biological control of insect pests, intestinal microflora, milk products, mycobacterial diseases of animals, microbial genomics, nitrogen fixing bacteria and improving plant growth, streptococci and the biological control of

OSMS streptococcal diseases, vaccine development and delivery systems, viruses and viral vaccines.

Website: http://microbiology.otago.ac.nz/dept/

Major Areas of Research Strength

Viral technologies A principal goal of virus research is to characterise virus to host interactions. Many viruses are a threat because they express a plethora of factors that subvert, suppress and generally manipulate human defences against infection. Viral factors that have been discovered and characterized include a set of chemokine binding proteins, a cytokine, a new class of vascular endothelial growth factor, a potent apoptosis inhibitor, a cell cycle regulator and a family of proteins that exploit the cell’s ubiquitination machinery. These viral factors target critical elements of our defences, and their analysis gives important new insights into both viral pathogenesis and our own physiological processes. There is also the opportunity to exploit these novel viral factors as new therapeutics in the treatment of pathologies quite removed from virus infection, for example, non-healing wounds and inflammatory disorders.

Website: http://microbiology.otago.ac.nz/dept/staff/mercer_andy/vru.html

Immunology An understanding of the immune response underpins studies of infectious and autoimmune diseases. Cures for these diseases, as well as cancer and asthma, require knowledge of the immune response and how it can be manipulated. Research focuses on the development of vaccines against cancer and infectious diseases such as Chlamydia, Johne’s Disease and tuberculosis. Studies are undertaken on the heritability of disease resistance mediated by immune response genes and how these interact with environmental stressors to compromise immunity. It also seeks to understand the immunology of autoimmune inflammatory diseases and the role of the immune system in asthma and other allergies.

Gastrointestinal microbiology Complex communities of bacteria inhabit the bowels of animals and have important influences on health and disease. These communities are referred to as the gut microbiota. Research interests include the molecular foundations of evolution; the gut microbiota and inflammatory bowel diseases; and the gut microbiota and atopic diseases of childhood.

Bacterial Physiology Research in this area is aimed at gaining an mechanistic insight into how bacteria sense and respond to their environment at the level of the cytoplasmic membrane. A major focus of this research is in determining the bacterial membrane proteins and signalling pathways involved and how they control the physiological response to environmental signals. Suudies are also carried out on nitrogen fixing bacteria in an attempt to develop superior strains to enhance nodulation of legumes.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P Greg Cook Shedding light on membrane protein biogenesis Marsden Fund Project 835,000 and repair in oxygenic photosynthesis

2008 Dr Alex McLellan How do we generate potent immune responses Marsden Fund Project 571,000 when infection strikes? A new role for T cell help in the immune response

46 RESEARCH REPORT 2007/2008 2008 Dr Sarah Young The use of virus-like particles as vaccines and HRC Sir Charles Hercus 499,996 therapies against cancer Research Fellowship

2008 Prof Andrew Mercer Viral Vaccines FRST Transition Funding 493,998

2008 Dr Peter Fineran Characterisation of a putative novel bacterial Marsden Fund Project 300,000 ‘two-component’ regulatory system conserved in a wide range of enteric bacteria

2008 Dr Sangsun Yoon Breaking up the Anaerobic Pseudomonas HRC Emerging 149,823

aeruginosa Biofilm Researcher First Grant OSMS

2008 Prof John Griffin Immunocompetence in cloned ruminants AgResearch, University 84,311 of Otago Collaborative Research Fund

2008 Prof Gerald Tannock Mechanisms of colitis induced by defined University of North 69,768 bacterial flora Carolina

2008 Prof Gerald Tannock Mechanisms of colitis induced by defined University of North 68,260 bacterial flora Carolina

2007 Prof Andrew Mercer Human pathogenic viruses HRC – Project 1,004,231

2007 Prof Gerald Tannock Food microbe host interactions NZ Institute of Crop 953,907 & Food Research, FRST

2007 Dr Sarah Young The use of virus-like particles as vaccines and HRC – Project 867,375 immunotherapies against cancer

2007 Dr Merilyn Hibma Regulation of host defences in the skin by a HRC – Project Extension 281,902 tumour-causing virus

2007 Prof Clive Ronson Carbohydrate Recognition and Signalling University of Aarhus Project 210,000

2007 A/P Gregory Cook The role of the toxin-antitoxin repertoire in University of Waikato 198,113 pathogen survival and persistence

2007 Prof Andrew Mercer New generation viral vaccines New Economy 117,212 Research Fund

2007 A/P Gregory Cook Methanogen ATP synthases as targets to AgResearch, UoO 100,930 control methane production in the rumen Collaborative Research Fund

2007 Cheng Mee Leong Manipulation of antigen presenting cells in Lottery General Project 94,823 the skin

Total $6,900,649

Total for all grants ≤ $50,000 awarded in 2007-8 $133,069

Total for all grants active in 2007-8 but awarded prior to 2007 $8,243,304

Grand total $15,277,022 * GST exclusive

Division of HEALTH SCIENCES 47 Research Contracts

Year Approved Organisation

2007-2008 Massey University LactoPharma New Zealand Animal Health Board Fonterra Research Centre Ltd New Zealand Institute of Crop & Food Research Zespri International Limited

OSMS Seperex Limited Johnes Research Group Cleveland Clinic, Lerner College of Medicine, Case Western Reserve University

Total $3,432,296

Postgraduate Students

Total Head Count* 2007 2008

PhD 36 32 Masters† 9 11

* as at 1 June each year † thesis or dissertation students only and includes MSc (BITE) and MSc (GENE) students

From left: Nicky Real, Dy Joel Tyndall, Professor Andy Mercer and Dr Lyn Wise

48 RESEARCH REPORT 2007/2008 Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr Sarah Young Sir Charles Hercus Health Research Fellowship, HRC

2008 Dr Alex McLellan University of Otago Early Career Award for Distinction in Research

2008 Stephanie Win TEC Bright Futures Top Achiever Doctoral Scholarship (PhD student) OSMS 2008 Sarah Saunderson Renshaw Prize (Best Summer Student Report to the OMRF) (PhD student)

2007 Prof Clive Ronson Fellowship to the Royal Society of New Zealand

2007 Mark Robinson Agricultural and Marketing Research and Development Trust Scholarship (PhD student)

2007 Dr Sarah Young OSMS Young Researcher of the Year

2007 Josh Ramsey Cambridge Fellowship (PhD student)

2007 Wayne Young Enterprise Scholarship (PhD student)

DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY

Head of Department: Associate Professor Cynthia Darlington. Email: [email protected]

The Department of Pharmacology and Toxicology engages in high quality, internationally-recognised research focused on the following themes of cellular and molecular neuropharmacology and neurotoxicology: cardiovascular signalling and cardioprotection; drug resistant cancer and drug metabolism; free radical biology; inflammation and wound healing; pharmacovigilance/pharmacogenetics; toxicology and neuroprotection, and vestibular pharmacology. State-of-the-art technologies, including in vivo disease models, are used to undertake integrative, cellular and molecular investigations aimed at understanding animal and human pathophysiology, and to delineate targets for novel drugs.

Website: http://phal.otago.ac.nz/

Major Areas of Research Strength

Disorders of the vestibular system Major research interests lie primarily in the function of the vestibular system, mechanisms of recovery from vestibular damage and the development of treatments for vestibular disorders. A particular research focus is tinnitus, a debilitating condition in which a person hears ringing or crackling in the ear. Approximately 1% of the population suffer from tinnitus, with the frequency increasing to 40% in people over 60. By identifying the specific molecular changes that occur in the brain in tinnitus, researchers hope to be able to design drugs that will selectively target the brain cells responsible and provide relief for sufferers.

Ion channels and neurological disorders Ion channels are small pores which can be activated by neurochemicals or by tiny voltage changes. Research is probing the physiology, pharmacology and toxicology of ion channels and receptors in the central nervous system. Primary interest lies in the structure and function of ion channels and their role in the pathogenesis of disease. These investigations have relevance to numerous important therapeutic areas, notably epilepsy, multiple sclerosis, stroke and neuroprotection, migraine, anxiety, Alzheimer’s disease, pain, sleep, anaesthesia and movement disorders.

Division of HEALTH SCIENCES 49 Neurotoxicology Toxic algal blooms occur with regularity throughout the world and pose a serious hazard to both human and animal health. A major area of research has been the mechanisms by which domoic acid (the active toxin in Amnesic Shellfish Poisoning) causes excitotoxic injury resulting in seizures, amnesia, and nerve cell loss. Studies are currently aimed at mechanisms of CNS neuroprotection and the super sensitivity of the aged brain to such excitotoxic insults. Results to date indicate that a novel CNS neuroprotective mechanism involves G protein-linked KA receptors which impart ‘tolerance’ to domoic acid and related excitotoxins. Age-related changes in hippocampal AMPA and KA receptors have been found to contribute to the aged brain’s increased susceptibility to excitotoxic damage.

OSMS External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Rhonda Rosengren New chemical entities for the treatment of The Breast Cancer 312,253 estrogen receptor negative breast cancer Research Trust

2008 Prof George Lees Probing roles for the novel histamine H4 NZ Neurological 102,720 receptor in the brain Foundation Project

2007 Dr John Ashton, Do cannabinoids heal the inflamed brain? Marsden Fund Project 222,224 Dr Michelle Glass The role of cannabinoid CB2 receptors in neurodegeneration and repair

2007 Professor Paul Smith Central nervous system mechanisms of tinnitus: Guardian Trust 148,536 The contribution of GABA

2007 Dr Gregory Giles Pharmacogenomic analysis of glutathione Lottery General Project 101,078 peroxidase mimetic anti-cancer activity

2007 Prof George Lees Closing the Gap on epilepsy – nerve cell Lottery General Project 84,864 channels and receptors as drug targets

Total $971,675

Total for all grants ≤ $50,000 awarded in 2007-8 $153,675

Total for all grants active in 2007-8 but awarded prior to 2007 $1,494,481

Grand total $2,619,831 *GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Industrial Research Ltd Seperex Limited

Total $243,420

Postgraduate Students

Total Head Count* 2007 2008

PhD 12 11 Masters† 7 7

* as at 1 June each year † thesis or dissertation students only

50 RESEARCH REPORT 2007/2008 DEPARTMENT OF PHYSIOLOGY

Head of Department: Dr Pat Cragg. Email: [email protected]

The Department of Physiology is engaged in high quality, internationally-recognised physiological research focused on the three themes of membrane and ion transport; cellular and molecular neuroscience; and circulation, integrative physiology and inflammation. State-of-the-art technologies, such as transgenic mouse models, are used to undertake integrative, cellular and molecular investigations aimed at understanding animal and human physiology.

Website: http://phsl.otago.ac.nz/ OSMS

Major Areas of Research Strength

Neural control of fertility Infertility is rapidly becoming more prevalent in western societies, including New Zealand. Major research being undertaken in the Department (in conjunction with the Centre for Neuroendocrinology) is focused on understanding the ways in which the brain controls fertility, including the onset of puberty and ovulation. A key study has found that kisspeptin, a small protein known to be vitally important for kick-starting puberty, also plays a critical role in the control of ovulation in the adult brain – a finding that may also offer hope for the infertile.

Neurophysiology of reward and Parkinson’s disease Research involves the use of a variety of neurophysiological techniques to investigate the function of selected areas of the brain. Two main strands of research concern (a) brain systems involved in the processing of information related to rewards (b) and circuits that underpin the normal generation of movement, their dysfunction in movement disorders such as Parkinson’s disease and the mechanisms by which treatments can restore normal functioning. Specific studies are investigating the neurophysiology of midbrain dopamine systems, and the reward-modulated activity of structures which modulate dopamine neuron activity. Understanding the neural mechanisms underlying movement disorders is important to guide development of new or enhanced treatments.

Cellular mechanisms and regulation of ion transport Research involves investigations into the mechanisms and regulation of solute and water movement across cell membranes and resultant pathologies. Current areas of interest include the regulation of epithelial ion channels by binding proteins and pharmacological agents, epithelial fluid and electrolyte transport in the intestine, and the control of sodium and water handling in obesity. Specific projects examine ion transport in the intestine of the Australian brush tail possum and the inhibition of Na+ channels by the Nedd4- and COMMD-families of proteins, modulation and trafficking of potassium channels in epithelia.

Cerebral blood flow and cerebral autoregulation in health and disease Research examines various physiological and pathophysiological aspects of the human cardiovascular and related systems. Current areas of interest include the regulation of cerebral blood flow and cerebral autoregulation in health and disease (for example sleep apnoea, stroke and heart failure); mechanisms of hypoxia-induced cerebral dysfunction; cerebral perfusion during exercise, thermal stress and syncope; and integration of the cardiorespiratory and cerebrovascular systems. Members of the laboratory travelled to Nepal last year to test first-hand the effects of high altitude on the human body.

Division of HEALTH SCIENCES 51 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P Brian Hyland, Nanosphere-based intelligent neurochemical Research project – 933,333 Dr John Reynolds delivery system: Intelligent delivery system for FRST brain chemicals

2008 Dr Istvan Abraham, Defining a new estrogen pathway to GnRH Marsden Fund Project 695,000

OSMS Prof Allan Herbison neurons

2008 Dr Istvan Abraham A novel approach in Alzheimer’s therapy: Neurological 179,737 investigating the ameliorative action of the Foundation Project synthetic estrogen

2008 Dr Colin Brown Neural hormonal communication in the brain Lottery Health 83,024

2008 Dr Paul Hessian Interplay between interleukin-17 and lymphoid Arthritis Foundation 52,354 neogenesis in Rheumatoid Arthroiditis

2007 Prof Allan Herbison Calcium oscillations in GnRH neurons HRC – Project 1,080,580

2007 Prof Allan Herbison Understanding calcium oscillations in GnRH Marsden Fund Project 650,668 neurons

2007 Dr Bernhard Schmitt Electrophysiology with electroneutral Marsden Fund Project 568,890 membrane transporters

2007 A/P Brian Hyland Neurophysiological basis of a novel treatment HRC – Project 389,243 for Parkinson’s disease

2007 Dr Ruth Empson Metabotropic Glutamate Receptor Signalling in NZ Neurological 180,284 Cerebellar Ataxia Foundation Project

2007 Prof Anthony Aqueous humor outflow control and intraocular University of 155,608 MacKnight pressure Pennsylvania

2007 A/P Brian Hyland Are dorsal raphe neurons activated by reward NZ Neurological 139,903 prediction? Foundation Project

2007 Dr Philip Ainslie Circadian rhythm, cerebral blood flow and Marsden Fund Project 124,443 nitric oxide

2007 Dr Shoichi Suzuki Role of TLR4 signalling in hepatic stellate cells in HRC Japan Society for 119,999 the early phase of liver regeneration the Promotion of Science

2007 Dr Philip Ainslie Research equipment and postdoctoral fellow – Lottery General Project 117,297 health, disease and aging.

2007 Dr Kirk Hamilton The regulation of the potassium channel, IK1, Lottery General Project 88,824 during the cell cycle

2007 Dr Christine Jasoni The long & winding road: Understanding Lottery General Project 88,057 guidance cues in GnRH neuron axon extension

Total $5,620,244

Total for all grants ≤ $50,000 awarded in 2007-8 $244,777

Total for all grants active in 2007-8 but awarded prior to 2007 $8,238,819

Grand total $14,103,840 *GST exclusive

52 RESEARCH REPORT 2007/2008 Research Contracts

Year Approved Organisation

2007-2008 AgResearch Animal Health Board

Total $890,652

Postgraduate Students OSMS

Total Head Count* 2007 2008

PhD 27 26 Masters† 4 5

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr Rebecca Campbell OSMS Emerging Researcher Award

2008 Anna Lindstrom Best Science Student Presentation – Gastroenterology Society (PhD student)

2008 Karen Peebles Hubbard Prize – Physiological Society of New Zealand (PhD Student)

2008 Rachel Cheong Bullivant Prize – Physiological Society of New Zealand (BBiomedSc Student)

2008 A/P Grant Butt DSM Investment Award

2008 A/P Grant Butt DSM Dean’s Research Advisory Committee Award

2008 Anna Lindstrom Sandy Smith Scholarship (PhD Student)

2008 Jenny Clarkson Exceptional PhD Thesis Award, University of Otago (PhD Student)

2007 Dr Phil Ainslie Early Career Award for Distinction in Research

2007 Jenny Clarkson Hubbard Prize – Physiological Society of New Zealand (PhD Student)

2007 Dr Emma Coddington Best Student Paper – Endocrine Society

2007 Rosie Geddes Bright Future Top Achiever Scholarship (PhD Student)

2007 Natalie Harfoot MacDiarmid Young Scientist of the Year Award, Science and our Society Category (PhD Student)

2007 Prof Allan Herbison Elected as Fellow of the Royal Society of New Zealand

2007 Prof Allan Herbison OSMS Distinguished Researcher of the Year Award

2007 Kelly McKelvey Tertiary Education Commission Top Achiever Doctoral Scholarship (PhD Student)

Division of HEALTH SCIENCES 53 DUNEDIN SCHOOL OF MEDICINE

DEPARTMENT OF GENERAL PRACTICE

Head of Department: Associate Professor Jim Reid. Email: [email protected]

The Department houses the Royal New Zealand College of General Practitioners Otago Research Unit, a group of international standing and one that is renowned for its general practice research in health services, health policy, and a wide range of clinical areas. The Department also runs an extensive programme of clinical research in rural medicine, medical education and teaching about primary care research design and methods. DSM Website: http://dnmeds.otago.ac.nz/departments/gp/index.html

Major Areas of Research Strength

Rural medicine Research incorporates issues of rural practice and service provision and includes: the role of the rural hospital generalist and in particular the interface with base hospital specialists; student attitudes to rural practice; rural hospital services; rural hospital cardiology including pre hospital fibrinolysis and management of acute coronary syndromes in the rural setting; and GIS role in supporting rural health service planning.

Medical education This is a major theme with teaching staff actively conducting research into teaching and learning at undergraduate and postgraduate level. The Department makes a significant contribution to research into teaching and learning within the Health Sciences Division. Areas of research interest include: socialisation in medical training; distance learning; professionalism in medicine; the hidden curriculum in medical education; evaluation of medical courses and curricula; education and vocational training for rural hospital generalists; and reflective practice.

Primary healthcare Research encompasses broader issues around the provision of primary care and policy development and implementation. Research interests focus mainly on patient safety; primary care structure and infrastructure; workforce; and quality measures. Research is underway to investigate the levels of patient safety in primary healthcare in New Zealand. A great deal of attention has been paid to patient safety in hospitals but safety in community-based care by GPs has received little consideration. One project involves the use of a nationally representative database of anonymised patient records to pinpoint any errors that may have occurred in patient care. Understanding what errors are occurring and how they are occurring are the first steps towards taking a proactive approach to advancing patient safety.

External Grants Awarded in 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Chrystal Jaye Investigation of undergraduate Medical students’ RNZCGP 4,444 discourses of General Practice and Surgery

Total $4,444

Total for all grants active in 2007-8 but awarded prior to 2007 $140,406

Grant total $144,850 *GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 5 6 Masters† 6 4

* as at 1 June each year † thesis or dissertation students only

54 RESEARCH REPORT 2007/2008 Awards and Scholarships

Year Researcher Award/Scholarship

2007 A/P Sue Dovey Distinguished Researcher Award, DSM

2007 Kelby Smith Research and Education Charitable Trust Grant RNZCGP

DEPARTMENT OF MEDICAL AND SURGICAL SCIENCES DSM

Head of Department: Professor Rob Walker. Email: [email protected]

The Department of Medical and Surgical Sciences was established in 1999 to facilitate multidisciplinary interactions between the six speciality sections in order to enhance teaching and research output. The six sections within the Department are: • Anaesthesia and Intensive Care • Bioethics Centre • Medicine • Ophthalmology • Orthopaedic Surgery • Surgery

Details of the research activities of each section follow.

ANAESTHESIA AND INTENSIVE CARE

Head of Section: Dr Geoff Laney. Email: [email protected]

Research activity in the Anaesthesia and Intensive Care Section relates mainly to the following topics: clinical pharmacology, clinical outcomes in the ICU, physiology of the critically ill and evidence-based practice.

Website: http://dnmeds.otago.ac.nz/departments/mss/anaesthesia/index.html

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2007 Dr Mathew Zacharias The pharmacokinetic, metabolic and safety profile Healthcare Otago 23,566 of intravenous paracetamol in adult patients undergoing major abdominal surgery

Total $23,566 * GST exclusive

BIOETHICS CENTRE

Director of Centre: Professor Donald Evans. Email: [email protected]

The Bioethics Centre was established in response to a growing awareness of new ethical issues relating to law, medicine and technology. The Centre, which has an international reputation, aims to encourage and co-ordinate teaching and research, to stimulate informed public debate, and to provide a consultation and resource service for health professionals and others in the community. Research interests in the Centre are diverse and include: medical ethics; ethics of emerging biotechnologies such as stem cell research, genetics and the new reproductive techniques; the ethical dimensions of resource allocation; cross-cultural and international ethics; philosophy of medicine, neuroscience and psychiatry; alternative medicine; animal ethics; clinical practice ethics; and research ethics. The Centre also plays a prominent role in national and international affairs in Bioethics.

Website: http://dnmeds.otago.ac.nz/departments/mss/bioethics/index.html

Division of HEALTH SCIENCES 55 Major Areas of Research Strength

Ethics of new and emerging biotechnologies Recent advances in biology and medicine leading to the emergence of new biotechnologies involving human genes, cells and tissues have introduced a plethora of ethical controversies. Many of these are being studied by researchers in the Centre including: assisted reproductive technologies; stem cell research; preimplantation genetic diagnosis; genetics; the Human Genome Project; human enhancement; genetic testing and screening; and social and genetic factors involved in mental health. An ongoing project is concerned with evaluating the commensurability and compatibility of Mäori perceptions of the emerging technologies with Pakeha views. The Centre is also a partner in the Law Foundation research project on the Ethics and Law concerning the clinical applications of the Human Genome Project. DSM International bioethics Cross-cultural and international bioethics is a major area of research. Much of the international bioethics research in the Centre focuses on China. Research themes to date have included ethical and socio-cultural dimensions of Japanese experimentation in wartime China; medical ethics in China; and population control and eugenics in China.

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Jing-Bao Nie Professional editing and indexing of a book Faculty of Medicine 6,200 manuscript Trust

Total $6,200

Total for all grants active in 2007-8 but awarded prior to 2007 $477,624

Grand total $483,824 *GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Ministry of Health New Zealand Society of Physiotherapists Inc

Total $37,942

Postgraduate Students

Total Head Count* 2007 2008

PhD 8 9 Masters† 13 10

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Nick Fancourt Fullbright Scholarship (MBHL student)

2008 Sarah Jones Max Charlesworth Essay Prize, Australasian Bioethics Association (MBHL student)

56 RESEARCH REPORT 2007/2008 MEDICINE

Head of Section: Professor John Highton. Email: [email protected]

Collaborative research projects link the Section of Medicine with other departments in the Division, as well as other universities in New Zealand and around the world. Areas of particular research strength include: rheumatic diseases, gastroenterological diseases, endocrinology, kidney disease, diabetes research, bone fractures in children and obesity, cardiac disease, falls in the elderly, cancer and respiratory illnesses.

Website: http://dnmeds.otago.ac.nz/departments/mss/medicine/index.html DSM

Major Areas of Research Strength

Diabetes research Approximately 157,000 New Zealanders have Type 1 or Type 2 diabetes. The Edgar National Centre for Diabetes Research (ENCDR) houses New Zealand’s foremost diabetes research team, involving a range of disciplines, including nutrition, epidemiology, health services research, Mäori health, biostatistics, public health and social marketing. Research aims to reduce the incidence of diabetes and its complications by finding new ways to prevent and manage the disease. Studies attempt to address the problem of diabetes and obesity by education, support and the promotion of healthy lifestyles in both children and adults. One key study has been the ‘Ngati and Healthy’ Prevent Diabetes Project, a two-year community-based programme to reduce diabetes risk factors in a Mäori community in the Tairawhiti East Coast region. The Centre for Translational Research in Chronic Diseases (CTRCD), which is affiliated to the ENCDR, is charged with the responsibility of evaluating the government’s public health approach to improving nutrition and physical activity and reducing obesity and its comorbidities.

Respiratory disease – asthma The causes, treatment and prevention of asthma are the central foci of The Otago Respiratory Research Unit. Key studies have revealed that not all asthmatics suffer from the same type of inflammation and not all will respond to commonly used inhaled steroid treatment. Studies are now being undertaken to identify alternative forms of treatment for this group. The group had previously revealed that long-term cannabis smoking is likely to produce similar adverse effects to tobacco smoking (chronic bronchitis, emphysema and lung cancer), and that the effects are noticeable even after smoking for a short time. In more recent times, a study of thirty asthmatics has revealed that obesity can worsen the impact of asthma and may also increase its severity. A larger study is now required to confirm results.

Bone health Research under this theme is multidisciplinary and focuses on changes in body composition during growth, bone density in osteoporosis, and the role of obesity, fat distribution, and nutrition in health and disease. Researchers in the department were the first to establish that children and adolescents with repeated forearm fractures suffer from low bone density throughout the skeleton. Research then revealed that obese children do not have adequate bone structure to support their increased weight and that they are at increased risk of fractures. The deleterious effect of avoidance of milk during childhood (i.e. poor skeletal development and obesity) was also demonstrated. Another dietary factor shown to be important in bone loss is high salt intake which leads to urinary loss of calcium.

Kidney disease It is estimated that one in eleven New Zealanders suffer from kidney disease, to which diabetes, obesity and other lifestyle factors are significant contributing factors. Early diagnosis and intervention can substantially reduce the numbers affected by kidney disease. Members of this group are dedicated to investigating innovative ways to prevent and treat kidney disease. The group’s expertise ranges from molecular and cellular-level investigations of kidney function, to applying therapies to prevent kidney injury or the progression of kidney disease. Research is aimed at better understanding the mechanisms of insult to the kidney, so as to allow earlier detection and better treatment. Efforts are underway to find new markers for early acute renal failure so it can be treated before irreversible damage or death occurs. Current research projects include: effects of lithium on renal function, molecular biology of polycystic kidney disease, dietary induced obesity and metabolic syndrome, clinical renal trials, renal function and high performance exercise, and progression of renal disease.

Rheumatology Research under this theme is varied. Major interest centres on the pathogenic pathways of rheumatoid arthritis. This research is attempting to determine the relationships of this classification to clinical outcomes, pathophysiologic pathways and treatment responses. The genetics of rheumatoid arthritis and gout is another area of strong research focus. A key project is “Genetics of Gout in Aotearoa” which is part of the new $3.4 million HRC programme grant lead by Dr Tony Merriman (Biochemistry, OSMS). Other areas of interest include ankylosing spondylitis, correlates of fatigue in chronic arthritis and scleroderma. With regard to the latter, researchers in the department contribute to EUSTAR - an international collaborative project to study the natural history of scleroderma.

Division of HEALTH SCIENCES 57 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P Gerard Wilkins W & GS Dick Fellowship Southland Medical 121,003 Foundation

2007 Prof Jim Mann Lifestyle and nutritional approaches to reducing HRC – Programme 2,116,152 obesity and type 2 diabetes and its complications extension DSM 2007 Dr Kirsten McAuley Study to develop a New Clinical Test to measure HRC – Project 454,494 insulin sensitivity

2007 A/P Gerard Wilkins W & GS Dick Fellowship Southland Medical 99,187 Foundation

Total $2,790,836

Total for all grants ≤ $50,000 awarded in 2007-8 $216,357

Total for all grants active in 2007-8 but awarded prior to 2007 $1,907,919

Grand total $4,915,112 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Ministry of Health, Auckland University of Technology, Massey University, Victoria University, Wellington, Native Consultancy Ltd Ministry of Health

Total $625,000

Postgraduate Students

Total Head Count* 2007 2008

PhD 8 11 Masters† 3 4

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Kelly Dale Young Investigator Award at the 25th Diabetes and Nutrition Study Group Symposium of (PhD student) the European Association for the Study of Diabetes, Finland

2007 A/P David Gerrard Companion of the New Zealand Order of Merit

2007 Prof Ailsa Goulding Slemenda Award for lifetime contribution to child bone health, 4th International Conference on Children’s Bone Health, Montreal, Canada

58 RESEARCH REPORT 2007/2008 2007 Prof Ailsa Goulding Marsden Medal, New Zealand Association of Scientists

2007 Prof Robin Taylor Distinguished Researcher Award, DSM

2007 Prof John Highton DSM Strategic Research Award

2007 Alwyn Todd First recipient of the New Zealand Dietetic Association Unilever Scholarship (PhD student) DSM OPHTHALMOLOGY

Head of Section: Professor Anthony Molteno. Email: [email protected]

The Ophthalmology Section has an active research focus. Major research areas include: The Otago Glaucoma Surgery Outcome Study, Internet based medical education, UV photography of the cornea, and long-term follow-up of orbital implants.

Website: http://dnmeds.otago.ac.nz/departments/mss/ophthalmology/index.html

Major Areas of Research Strength

Glaucoma Glaucoma is the number one cause of preventable blindness in New Zealand. The Otago Glaucoma Surgery Outcome Study is based in the department and it is the world’s longest ongoing follow-up study into surgery for glaucoma. Approximately 1400 patients have been followed to determine outcomes following implant surgery or trabeculectomies at Dunedin Hospital since 1976. Aspects of the study have included: the development of an effective draining implant for previously severe or untreatable glaucoma; investigations into interactions between the glaucoma aqueous from the eye, the implant itself and the patient’s tissues; and the development of drug regimes for use with implants in conventional glaucoma surgery to improve results. The electronic database of operations in the Otago Glaucoma Surgery Outcome Study now provides data for studies aimed at defining the long-term results of glaucoma drainage surgery.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2007 Prof Anthony Molteno Otago Glaucoma Surgery Outcome Survey Healthcare Otago 107,733

Total $107,733 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD - - Masters† 2 2

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 59 ORTHOPAEDIC SURGERY

Head of Section: Associate Professor Jean-Claude Theis. Email: [email protected]

Research interests in the Orthopaedic Surgery Section include: orthopaedic surgery and joint replacement, spinal and scoliosis surgery, paediatric surgery, joint arthroplasty, hand and upper limb surgery, cartilage repair, and the development of bioabsorbable orthopaedic implants. There are also two commercially funded units within the Department, both of which have as their prime interests, the reactions of tissues to surgical implants.

Website: http://dnmeds.otago.ac.nz/departments/mss/orthopaedic/index.html DSM

Major Areas of Research Strength

Paediatric surgery and screening The major research interests are ultrasound imaging of the neonatal hip and epidemiology and screening of developmental dysplasia of the hip (DDH or clicky hip). All babies born in New Zealand hospitals will undergo a physical examination to check for DDH, a disorder where the thigh bone can easily dislocate from the hip socket. However, DDH is a difficult diagnosis. An innovative screening programme involves scanning at risk babies with ultrasound imaging. This programme has dramatically reduced the number of children with DDH, and has also reduced the number of babies who are misdiagnosed with the disorder and treated unnecessarily.

Joint repair and orthopaedic implants Researchers are studying the cellular mechanisms of joint injury and repair, with particular emphasis placed on the biology and function of articular cartilage in a joint. The ultimate goal is the engineering of new cartilage that could be inserted into a damaged joint to restore it to normal pain-free functioning. The development of bioabsorbable orthopaedic implants is an additional research theme. Types of implants under development include: an absorbable suture anchor for the attachment of soft tissue to bone; and absorbable interference screws for the fixation of bone-tendon-bone grafts in anterior cruciate ligament reconstruction.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P Anthony Poole A key role for the chondrocyte primary cilium Arthritis NZ 121,277 in cartilage tissue engineering Project Grant

2008 A/P Jean-Claude Theis Dunedin Acute Back Pain Study Realhealth International 60,644

2007 A/P Tony Poole The primary cilium and mechanosensation: A Marsden Fund Project 764,447 novel approach to understanding kidney fibrosis

Total $946,368

Total for all grants ≤ $50,000 awarded in 2007-8 $72,461

Total for all grants active in 2007-8 but awarded prior to 2007 $32,666

Grand total $1,051,495 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 3 3 Masters† - -

* as at 1 June each year † thesis or dissertation students only

60 RESEARCH REPORT 2007/2008 Awards and Scholarships

Year Researcher Award/Scholarship

2008 Markus Melloh Best Poster Award, Spine Society of Australia (PhD student)

SURGERY DSM Head of Section: Professor Andre van Rij. Email: [email protected]

The department of Surgery aims to excel in clinical teaching and training, the linking of basic science with clinical research and the development of the discipline in New Zealand and internationally. The Section of Surgery has two major research units: The Otago Clinical Audit and Outcomes Research Group, and the Vascular Research Group.

Website: http://dnmeds.otago.ac.nz/departments/mss/surgery/research.html#audit

Major Areas of Research Strength

Vascular research The Vascular Research Group in the Department has a broad range of interests in the field of vascular biology, including vascular connective tissue biology and the genetic basis of human vascular disease. One recent key study has shown that a seldom-measured lipoprotein in the blood, already identified as a risk factor for coronary artery disease, is also a risk factor for stroke, peripheral vascular disease and abdominal aortic aneurysm within the same population. In another study, one of the largest of its kind in the world, the group is studying aneurysms. Over the last 10 years they have looked at 600 cases of large aneurysms and through the recruitment of volunteers, 600 control cases.

Work with overseas collaborators has identified a common genetic variation that increases a person’s susceptibility to nicotine addiction, as well as increasing their risk of lung cancer and arterial disease. This study has been published in the prestigious journal Nature11.

Website: http://dnmeds.otago.ac.nz/departments/mss/surgery/vascular.html

Clinical audit and outcomes research The Otago Clinical Audit and Outcomes Research Group promotes the development of clinical audit within the surgical profession and develops systems for evaluating longer term outcomes in clinical practice. Developing and enhancing software to support these processes has also been a dominant role of the Unit. The Unit has produced significant research focusing on the process of surgical audit including risk stratification in outcome assessment.

A key example of the Unit’s activities is the development of a very successful national system for audit for vascular surgery. Data on 55,000+ patients is available in the audit database to assist peer-review, to answer enquiries from clinical management, to determine surgical workloads, to monitor training of registrars and to evaluate overall surgical performance.

Website: http://www.otago.ac.nz/ouaudit/

11 Thorgeirsson TE, et. al (including Jones GT, and van Rij AM). (2008). A variant associating with nicotine dependence, lung cancer and peripheral arterial disease. Nature 452: 638-642.

Division of HEALTH SCIENCES 61 External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Greg Jones Whole genome analysis for risk markers of HRC – Project 1,385,683 abdominal aortic aneurysm

2008 Dr Greg Jones Validation of putative genetic markers associated Faculty of Medicine 15,000 with abdominal aortic aneurysm Trust DSM 2007 Mr Patrick Dawes New approaches to reduce mucosal Candida Healthcare Otago 24,163 infections and voice prosthesis failure

Total $1,424,846

Total for all grants active in 2007-8 but awarded prior to 2007 $195,925

Grand total $1,620,771 *GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Auckland District Health Board Institut de Recherches Internationales Servier (IRIS)

Total $95,958

Postgraduate Students

Total Head Count* 2007 2008

PhD 4 5 Masters† 1 1

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Tina Chen DSM Clinical Research Scholarship (PhD student)

62 RESEARCH REPORT 2007/2008 DEPARTMENT OF PATHOLOGY

Head of Department: Professor Ian Morison. Email: [email protected]

Areas of current research activity in the Department include: cancer biology, mitotic spindle checkpoint control and the role of mismatch repair genes, developmental biology with emphasis on the development of the kidney and renal diseases, epigenetics, the genetics of bipolar disorder and the effects of mood stabilising drugs. Much of the research is multidisciplinary in approach, is clinically relevant, and involves collaboration with clinical and scientific colleagues in other Departments within the School, University or elsewhere in New Zealand, as well as international links.

The Department houses a number of research groups: the Molecular Genetics Laboratory, the Molecular Pathology Group, the DSM Cancer Research Laboratory, the Cell Transformation Group, the Developmental Genetics Group, the Chromosome Structure and Development Group and the Clinical Genetics Group.

Website: http://dnmeds.otago.ac.nz/departments/pathology/research.html

Major Areas of Research Strength

Cancer research A major research theme in the Pathology Department is cancer research. This is the major research activity of the Molecular Genetics Group, the Cancer Research Laboratory, the Cell Transformation Group, and the Developmental Genetics Group. The over-arching interest of the above groups is the identification, characterisation and functional analysis of genes that contribute to the development of cancer. This includes genes responsible for rare inherited predispositions to cancer, as well as genes that are defective in the more common sporadic forms of cancer. There is a strong focus on identifying suitable ‘markers’ which are specific to cancer diagnosis. These markers are useful in screening large populations, in detecting patients with cancer at an early stage, and in monitoring patients after treatment for recurrence. Cancers that are being studied include colorectal, breast, cervical and skin cancers. A particular emphasis is also placed on the molecular genetics of embryonic renal tumours, tumour suppressor gene function, in particular p53, and cancer vaccine development.

Developmental genetics The Developmental Genetics Group is the focus of departmental research in this area. Research revolves around three broad themes: 1. understanding growth and patterning of tissues in relation to function, 2. investigating altered genetic control mechanisms, and identifying opportunities for therapeutic intervention in developmentally abnormal and malignant tissues and 3. understanding how proteins responsible for normal chromosome architecture during the cell cycle can also contribute to gene expression, animal development and cancer.

Present research themes include: • Developmental biology of the kidney and urinary tract, and associated diseases • Modelling of genetic disease and analysis of the underlying molecular defects • Cell survival during development • Cell survival and developmental mechanisms in cancer and identification of therapeutic targets for cancer treatment

Website: http://dnmeds.otago.ac.nz/departments/pathology/devgen/index.html

Chromosome structure and development The Chromosome Structure and Development Group is interested in how proteins necessary for normal chromosome architecture during the cell cycle can also contribute to gene expression, animal development and cancer. The main focus of research is exploring alternative roles for proteins needed for sister chromatid cohesion during mitosis. The majority of research makes use of the genetically amenable vertebrate animal model, the zebrafish. Since there is high conservation of developmental genes throughout evolution, information gained from the zebrafish model will be used to interpret the developmental roles of cohesin in mammals including humans.

Website: http://dnmeds.otago.ac.nz/departments/pathology/csdg/index.html

Childhood acute lymphoblastic leukaemia There is strong evidence to suggest that environmental factors contribute to the incidence of childhood acute lymphoblastic leukaemia (ALL). It is hypothesised that epigenetic events (DNA-methylation) contribute to the onset of ALL. Medium- throughput techniques have been used to identify genes that are highly methylated leading to gene silencing in ALL. Functional studies are being performed to characterise candidate genes. Professor Ian Morison joined the Department in February 2009 and he leads this research group.

Division of HEALTH SCIENCES 63 Clinical genetics The Department of Pathology houses the Clinical Genetics Research Group but staff of this group are employed by the Department of Women’s and Children’s Health. Please see this Department for details.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

DSM 2008 Dr Julia Horsfield How does Rad21 regulate the Myc Oncogene? The Breast Cancer 97,607 Research Trust

2008 Dr Alison Fitches Pathways to panic: genetics in the pathogenesis HRC Fellowships and treatment of panic and Scholarships 85,000

2007 Profs Antony Therapeutic and diagnostic markers of cancer: HRC Programme Braithwaite, Mike Eccles From bench to clinic Extension 2,640,067

2007 Dr Julia Horsfield Investigating chromosome cohesion syndromes in Marsden Fund 750,224 zebrafish: how does development come unstuck? Project

2007 Prof Michael Eccles Chair in Cancer Pathology (Advancement Trustees of the 499,999 Campaign) University of Otago Foundation Trust

2007 Dr Janice Royds Pax - the Achilles heel for gliomas? Cancer Society Project 216,078

2007 Dr Julia Horsfield A Zeb Tec 6-rack Multi-linking zebrafish system Lottery Health Research 120,000

2007 Prof Michael Eccles PAX2 and mTOR - is there a connection? Lottery General Project 66,740

Total $4,475,715

Total for all grants ≤ $50,000 awarded in 2007-8 $265,233

Total for all grants active in 2007-8 but awarded prior to 2007 $6,024,046

Grand total $10,764,994 *GST exclusive

Research Contracts

Year Approved Organisation

2007 Otago Innovation Limited

Total $46,655

Postgraduate Students

Total Head Count* 2007 2008

PhD 8 6 Masters† 4 3

* as at 1 June each year † thesis or dissertation students only

64 RESEARCH REPORT 2007/2008 Awards and Scholarships

Year Researcher Award/Scholarship

2007 A/P Peter Schwartz Member of the New Zealand Order of Merit

DEPARTMENT OF PREVENTIVE AND SOCIAL MEDICINE

Head of Department: Associate Professor Rob McGee. Email: [email protected] DSM

The Department of Preventive and Social Medicine constitutes one of the leading centres for public health research in Australasia. There are a number of major research groups within the Department including: the Injury Prevention Research Unit, the Dunedin Multidisciplinary Health and Development Research Unit, the Hugh Adam Cancer Epidemiology Unit, the Ngäi Tahu Mäori Health Research Unit, the AIDS Epidemiology Group, the Cancer Society Social and Behavioural Research Unit, and the Centre for International Health. The New Zealand Pharmacovigilance Centre, and the National Poisons Centre are also hosted in the Department. Details of a number of these Units and Centres can be found in the section on Research Centres.

Website: http://dnmeds.otago.ac.nz/departments/psm/index.html

Major Areas of Research Strength

Lifecourse research The Dunedin Multidisciplinary Health and Development Research Unit (DMHDRU) conducts the Dunedin longitudinal study, one of the most detailed studies of human health and development ever undertaken. A multidisciplinary, longitudinal study of 1,037 babies born in Dunedin during 1972/73, the Study members have been followed up since birth, at age three, then every two years to age 15, and at ages 18, 21, 26, and 32. Planning is underway to next see the Study members at age 38. For each follow-up phase, the Study members are brought to the Dunedin Unit where they undergo numerous assessments and measures of their health and development. The main research focus is human development over the lifecourse. Other studies run by DMHDRU include those of the parents of the original Study Members (Family Health History Study), parenting behaviours of Study Members (Parenting Study), and the 15-year-old children of Study Members (Dunedin Next Generation Study). The research will provide ground-breaking information across three generations of New Zealand families. Knowledge gleaned from the Study has influenced family, child and public health policies and practice nationally and internationally.

The Dunedin Multidisciplinary Health and Development Research Unit is also a founding partner in the National Centre for Lifecourse Research.

Website: http://dunedinstudy.otago.ac.nz/

Injury Prevention The goal of IPRU is to undertake research that will contribute to reducing the incidence, severity, and consequences of injury in New Zealand. IPRU addresses multiple dimensions of the injury problem. The current programme of work is categorized into the following, non-mutually exclusive, areas: Road safety, Sport and recreation, Injury to Children, Surveillance, Occupational injury, Intentional injury, Alcohol-related harm, Biomechanics of injury, Rehabilitation and disability. IPRU’s research is highly relevant to injury prevention policy and programmes. Recent examples include: the alcohol purchase age, and driver licensing age, indicators for measuring progress on reducing injury.

Website: http://www.otago.ac.nz/ipru/

Cancer The Department has significant expertise in cancer research, with two research Centres dedicated to this field: the Hugh Adam Cancer Epidemiology Unit (HACEU) and the Cancer Society Social and Behavioural Research Unit (SBRU).

The focus of cancer epidemiology research of the department is the HACEU. The HACEU is involved in several national and international studies of the prevention, causes, impact, burden and consequences of cancer as well as assessments of cancer incidence, mortality and survival in New Zealand. Research also includes the evaluation of the conduct of cancer prevention programmes and cancer screening, particularly their impact on cancer of the bowel, breast, prostate, cervix, lung, and melanoma. Many projects involve other members of staff of the department.

Division of HEALTH SCIENCES 65 The SBRU is the focus of research into social and behavioural aspects of cancer. To date, it has worked mainly in the priority areas identified for the primary prevention of cancer in New Zealand, that is tobacco control, healthy physical activity and nutrition, and ultraviolet radiation exposure.

Website: http://www.otago.ac.nz/sbrcg

International health The Centre for International Health is based in the Department. The Centre aims to make a significant contribution to the understanding, development and well-being of individuals and populations in developing countries. Research projects and collaborations are underway with other institutes in the Gambia, Indonesia, Samoa and Cambodia. DSM Website : http://dnmeds.otago.ac.nz/departments/psm/research/international_hlth/index.html

Hauora Mäori Rangahau hauora Mäori (Mäori health research) is an important part of the research portfolio of the Department. The goal of the Ngäi Tahu Mäori Health Research Unit is to contribute to the body of knowledge on Mäori health that will lead to positive health outcomes for Mäori and their whänau. The Unit collects, collates, interprets and publishes information, data and statistics on Mäori health issues. The research focuses for the Unit are: hauora rangatahi (young people’s health); hauora wahine (Mäori women’s health) and oranga niho (dental health).

AIDS epidemiology The AIDS Epidemiology Group has been responsible for national surveillance of AIDS and HIV infection in New Zealand since 1989. The aims of the Group are to monitor the epidemic of HIV/AIDS in New Zealand through ongoing surveillance; to develop, and when appropriate to apply, new methods of monitoring and evaluation; and to contribute to the wider knowledge of HIV infection and AIDS.

Other research The Department of Preventive and Social Medicine is a very research-intensive department and has a number of other areas of research strength including: poisons research; pharmacovigilance; renal disease; human development; environmental health; epidemiology of infectious diseases; health policy and economics and occupational health and alcohol-related harm.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Robert Hancox The Dunedin Next Generation Studies HRC – Project 1,850,398

2008 Dr Anthony Reeder CSNZ Social and Behavioural Research Unit – Cancer Society 900,001 core funding

2008 Dr Patricia Priest Hand sanitiser to reduce illness absences in HRC – Project 797,205 primary school children

2008 Dr Sarah Derrett Prospective outcomes of injury study (POIS) ACC 400,001

2008 Dr Sarah Derrett A longitudinal study of the life histories of Massey University 268,414 people with spinal cord injury

2008 Dr Jennie Connor Evaluation of Community based initiative to National Drug Policy 107,186 (with K Kypri) reduce alcohol-related harm and disorder Discretionary Fund and Alcohol Advisory Council

2008 Ms Kate Morgaine Improve oral health of rangatahi in Taranaki by HRC – Project 100,000 increasing service utilisation

2008 Dr Mira Harrison- Developing electronic capture of medicines HRC Partnership Woolrych exposure data for improved product vigilance Programme 100,000 in NZ

66 RESEARCH REPORT 2007/2008 2008 Prof Richie Poulton Data collection, cleaning and reduction: Dunedin Duke University 99,000 study phase 32 mental health interviews

2008 Dr Lianne Parkin Feasibility of monitoring drug safety through HRC Partnership 88,700 linkage of existing prescription and outcome data Programme held in NZ Health Information Services databases

2008 Dr Shyamala An internet based CBT self-help for depression: Ministry of Health 75,003 Nada-Raja A randomised controlled trial

2008 Ms Helen Harcombe Longitudinal survey of musculoskeletal disorders Strategy to Advance 75,000 DSM and related disability in NZ Research under TEC BRCSRA

2007 Dr Dorothy Jean Begg New Zealand Drivers Study: A follow-up study ACC Road Safety Trust 1,971,367 of newly licensed drivers

2007 A/P Brian Cox Colorectal cancer control in New Zealand HRC 1,397,629 (with others)

2007 Dr Sarah Derrett Prospective outcomes of injury study: POIS HRC – Project 1,343,900

2007 A/P Brian Cox Support for Hugh Adam Unit AMP Perpetual Trustee 681,387

2007 Dr Shyamala An internet based CBT self-help for depression: ACC 427,053 Nada-Raja A randomised controlled trial

2007 Dr Shyamala Nada-Raja An internet based CBT self-help for depression: HRC – Project 355,383 A randomised controlled trial

2007 Dr Anthony Reeder Quantifying the association between sun exposure Auckland University 330,000 and vitamin D status in New Zealanders

2007 Dr Anthony Reeder Health Research Council of NZ Partnership HRC 599,476 (with UOW) Programme: Developing strategies to reduce smoking uptake and SHS exposure of NZ children

2007 Dr Pamela Smart Water Safety Research: Comparative studies and ACC 264,483 database development

2007 Ms Kimberly Cousins Evaluation of a community-based initiative to HRC/ACC 103,607 reduce alcohol-related harm and disorder – PhD Scholarship

Total $12,335,933

Total for all grants ≤ $50,000 awarded in 2007-8 $347,988

Total for all grants active in 2007-8 but awarded prior to 2007 $11,215,583

Grand total $23,899,504 * GST exclusive

Division of HEALTH SCIENCES 67 Research Contracts

Year Approved Organisation

2007-2008 ACC Dow Chemical Company Ministry of Health Auckland Uniservices Otago DHB Healthcare Otago Charitable Trust

DSM Water Safety New Zealand New Zealand Blood Services SPARC Cancer Society of New Zealand

Total $6,722,238

Postgraduate Students

Total Head Count* 2007 2008

PhD 29 37 Masters† 12 14

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 A/P Robin Gauld Commonwealth Fund Harkness Fellowship in Health Policy

2008 Prof Richie Poulton Dunedin School of Medicine Publication Award

2008 Dr Mary Butler Accident Compensation Corporation Post-doctoral Early Career Development Award

2008 Dr Rose Richards Health Sciences Career Development Post-doctoral Fellowship

2008 Sandhya Ramrakha University of Otago Postgraduate Publishing Award

2008 Helen Harcombe STAR Foundation PhD Fellowship (PhD student)

2008 Robin Quigg Dunedin School of Medicine PhD Start-up scholarship (PhD student)

2007 Robin Quigg University of Otago Mäori scholarship (PhD student)

2007 Dr Emma Wyeth Health Research Council Eru Pomare Post-doctoral Research Fellowship

2007 Dr Rebecca Lilley Accident Compensation Corporation Post-doctoral Early Career Development Award

2007 Kimberley Cousins Accident Compensation Corporation PhD Career Development Award (PhD Student)

2007 Dr Rose Richards University of Otago Postgraduate Publishing Award

2007 Dr Rose Richards Exceptional PhD Thesis in the Division of Health Sciences

68 RESEARCH REPORT 2007/2008 DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Paul Glue. Email: [email protected]

The Department of Psychological Medicine consists of the two main units of Clinical Psychiatry and Behavioural Science. Both units are involved in a variety of clinically relevant research areas, including self-harm and suicide, delusions, schizophrenia, community mental health epidemiology, anxiety and depression, substance misuse and addictions, sexual health and HIV, primary care interventions, communication and consultation skills, gender, religion and mental health, cognitive processes, behavioural aspects of physical health, child abuse, exploration of developmentally appropriate techniques for gathering information from children, child therapies, and psychopharmacology. The Department has close ties with the

Dunedin Multidisciplinary Health and Development Research Unit. DSM

Website: http://dnmeds.otago.ac.nz/departments/psychological/index.html

Major Areas of Research Strength

Sexual health and HIV Research looks at the mental health and quality of life of different population groups of HIV positive people.

New directions In late 2008, a leading researcher, Professor Paul Glue was appointed to the Hazel Buckland Chair in Psychological Medicine and is chair of the Department. Professor Glue’s research spans clinical and basic science. His areas of interest include the pharmacology of drug treatments in psychiatry and the investigation of disease mechanisms in neurological and psychiatric disorders. He is also interested in technical aspects of clinical trial design, including trialling simulation and modelling.

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2007 Dr Richard Mullen Schizophrenia: outcome psychosis, experience James Hume (ScOPE) Bequest Fund 58,382

Total $58,382

Total for all grants active in 2007-8 but awarded prior to 2007 $9,777

Grand total $68,159 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 2 3 Masters† 1 2

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 69 DEPARTMENT OF WOMEN’S AND CHILDREN’S HEALTH

Head of Department: Professor Barry Taylor. Email: [email protected]

The Department of Women’s and Children’s Health comprises the Section of Obstetrics and Gynaecology and the Section of Paediatrics. The Section of Obstetrics and Gynaecology has a strong research focus, specifically, infertility, urogynaecology, diabetes in pregnancy, gynaecological oncology, laparoscopy and microsurgery audit, decision analysis, quality assurance, ovarian ultrastructure and biology, and management of high-risk pregnancy and prenatal diagnosis. Staff members are involved with secondary research in urogynaecology, and with the Cochrane Incontinence Review Group.

DSM Website: http://dnmeds.otago.ac.nz/departments/womens/obstetrics/index.html

The Section of Paediatrics also has a strong research focus, with areas of particular strength including sudden infant death syndrome, asthma, sleep related breathing disorders, the National Mortality Review for Children, genetics of congenital malformations, neonatal and paediatric endocrinology, and ethics and clinical genetics.

Website: http://dnmeds.otago.ac.nz/departments/womens/paediatrics/index.html

Major Areas of Research Strength

Clinical genetics Congenital birth defects affect one in every 30 children born in New Zealand and many aspects of their genesis remain a mystery. The prime thrust of clinical genetics research is the identification of the genetic determinants of congenital birth defects in children. This research is carried out in conjunction with the Department of Pathology, Dunedin School of Medicine. Disorders under investigation include: the otopalatodigital syndrome spectrum disorders; the Larsen syndrome-atelosteogenesis spectrum; periventricular nodular heterotopia; other X linked multiple malformation conditions; and De Barsy syndrome. The ethical consequences of the application of genetic information in the clinical arena are also being studied.

Website: http://dnmeds.otago.ac.nz/departments/womens/paediatrics/research/cgg/index.html

Sleep related breathing disorders Otago’s Paediatric Sleep Research Group is researching the connection between child and adolescent sleep related breathing disorders (SRBD) and two other common childhood conditions: obesity and attention deficit hyperactivity disorder (ADHD). Many children who are overweight suffer from sleep apnoea and researchers are investigating these links. It is hoped that the findings will be used ultimately as part of an obesity treatment and prevention campaign for adolescents. There is also evidence to suggest that SRBD may be associated, in some cases, with attention deficit hyperactivity disorder (ADHD). Studies are investigating this association and whether treatment of SRBD results in improvement in symptoms of ADHD.

Paediatric surveillance The New Zealand Paediatric Surveillance Unit was established with funding from the Ministry of Health in order to undertake surveillance of acute flaccid paralysis. Such surveillance is required by the World Health Organisation to ensure that New Zealand is free of poliomyelitis as part of its global eradication process. Since then the national surveillance of other uncommon but high impact childhood conditions has been undertaken with the aim of improving the knowledge of these conditions in New Zealand. Examples of conditions of interest include: congenital rubella; perinatal HIV exposure; haemolytic uraemic syndrome; haemorrhagic disease of the newborn; pneumococcal meningitis; and bronchiectasis.

Childhood obesity This is a new focus of research led by Professor Barry Taylor, which has gathered a network of researchers across the University and nationally, bringing together a very multidisciplinary group. A number of research and strategy workshops have been held. In 2008, this group attracted major funding from the HRC for a project addressing primary prevention of rapid weight gain in early childhood.

Incontinence The Cochrane Incontinence Group provides the focus for this research theme within the Department. The goal of the group is to introduce interventions designed to prevent or treat incontinence, or aid rehabilitation. The problems covered include urinary or faecal incontinence; enterocutaneous or enterovesical fistulae; enuresis; day-time wetting in children; encopresis; post prostatectomy stress incontinence; use of urinary catheters including catheter-related urinary tract infections; neurogenic incontinence and retention; post operative urinary retention; and rectal or vaginal prolapse.

70 RESEARCH REPORT 2007/2008 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Barry Taylor Primary prevention of rapid weight gain in early HRC – Project 2,221,742 childhood

2008 Dr Barbara Galland Early childhood sleep and breathing disorders: HS & JC Anderson 57,756 when should we treat? DSM 2007 Prof Stephen Finding genes underlying a neuronal migration Child Health 100,660 Robertson disorder in children Research Foundation

2007 Ms Amelia Gill Does snoring in early childhood impair cognitive Freemason’s Postgraduate 72,128 development and learning? Fellowship

2007 Ms Catherine Sherwin Masonic Postgraduate Fellowship – Freemason’s Postgraduate 70,892 Catherine Sherwin Fellowship

2007 Prof Stephen Genes for healthy skeletal development Lottery General Project 62,949 Robertson

Total $2,586,127

Total for all grants ≤ $50,000 awarded in 2007-8 $73,607

Total for all grants active in 2007-8 but awarded prior to 2007 $1,424,059

Grand total $4,083,793 * GST exclusive

Research Contracts

Year Approved Organisation

2007 Ministry of Health

Total $821,944

Postgraduate Students

Total Head Count* 2007 2008

PhD 7 5 Masters† 1 -

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 71 Awards and Scholarships

Year Researcher Award/Scholarship

2008 Prof Barry Taylor DSM Distinguished Researcher Award

2008 Prof Stephen DSM Distinguished Researcher Award Robertson

2007 Evan Tan Dunbar Scholarship

DSM (PhD student)

2007 Catherine Sherwin Masonic Fellowship (PhD student)

2007 Amelia Gill Masonic Fellowship (PhD student)

2007 Anna Hamlin Masonic Fellowship (PhD student)

2007 Nikki Kerruish Lady King Scholarship (PhD student)

From left: Dr Zandra Jenkins, Margriet van Kogelenberg and Professor Stephen Robertson of the Clinical Genetics Research Group

72 RESEARCH REPORT 2007/2008 UNIVERSITY OF OTAGO, CHRISTCHURCH

DEPARTMENT OF ANAESTHESIA

Head of Department: Professor Ted Shipton. Email: [email protected]

The Department of Anaesthesia has a small but active research programme. Recent areas of interest include volatile anaesthetic uptake and distribution; perioperative pain relief; predictors and risk factors for persistent acute postoperative pain; and psychosocial adjustment and physical health of children living with mothers with chronic pain.

Website: http://www.chmeds.ac.nz/departments/anaesthesia/index.htm UOC

Major Areas of Research Strength

Anaesthetic uptake and distribution Research has been undertaken on anaesthetic monitoring particularly. A computer programme has been developed to predicatively model anaesthetic uptake and distribution. Collaborating with an Australian team, the pharmacokinetics of sevoflurane uptake into the brain have been modelled, and the relationship between calculated effect-site sevoflurane levels and awakening from anaesthesia has been studied. The safe delivery of anaesthesia has also been examined in patients with mitochondrial myopathies and prolonged QT syndromes.

Postgraduate Students

Total Head Count* 2007 2008

PhD 1 1 Masters† 1 1

* as at 1 June each year † thesis or dissertation students only

DEPARTMENT OF MEDICINE

Head of Department: Professor Zoltan Endre. Email: [email protected]

The Department of Medicine has diverse research interests and hosts a number of very productive research groups. Areas of research include cardioendocrinology, respiratory research, renal disease, clinical pharmacology, neurology, rheumatology; and healthcare of the elderly.

Website: http://www.chmeds.ac.nz/departments/medicine/index.htm

Major Areas of Research Strength

Cardioendocrine research Cardioendocrine research is undertaken by members of the Christchurch Cardioendocrine Research Group (CCERG). Research is aimed at defining those plasma neurohormonal measurements, cardiac imaging features, and genotypes which provide the best diagnostic, prognostic and therapeutic potential for detection and management of heart failure. The Group is also involved in a community heart study to assess the proportion of Mäori living with undiagnosed heart disease, diabetes, hypertension, high cholesterol or other significant cardiovascular disease risk factors. The work of the CCERG has provided a large bank of practical knowledge that is used by cardiologists to monitor the prognosis and treatment of patients who have suffered heart attacks. The Group’s world leading research on natriuretic peptides has contributed to several clinical trials on their use.

Website: http://www.chmeds.ac.nz/research/cardioen/index.htm

Division of HEALTH SCIENCES 73 Kidney disease Research is directed towards investigating innovative ways to prevent and treat kidney disease. Expertise ranges from molecular and cellular-level investigations of kidney function, to applying therapies to prevent kidney injury or the progression of kidney disease. The aim is to better understand the mechanisms of insult to the kidney, so as to allow earlier detection and better treatment. Efforts are underway to find new markers for early acute renal failure so it can be treated before irreversible damage or death occurs. Current research projects include: pathophysiology and early detection of acute renal failure; roles of apoptosis, growth factors, cell survival genes, nitric oxide and free radicals in acute renal failure; clinical renal trials, and progression of renal disease.

Clinical pharmacology

UOC The clinical application of pharmacology knowledge is the focus of the Clinical Pharmacology Research Group. This Group includes staff from the Clinical Pharmacology Department at Christchurch Hospital, the Drug Information Service and the Drug Utilisation Review Service. Current research interests include: pharmacogenetics; drug metabolism in the elderly; drug use in pregnancy and lactation; antibiotic dosing regimens - especially for the aminoglycosides; phase III drug trials of gastroenterology drugs; provision of drug information; adverse drug reactions; and thiopurine drugs.

Website: http://www.chmeds.ac.nz/research/pharmacology/index.htm

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Mark Richards Prediction of onset and outcomes in coronary HRC – Project 1,758,769 heart disease.

2008 Prof Mark Richards Chair in Cardiovascular Studies National Heart 700,002 Foundation Project

2008 Prof Mark Richards Urocortin 2 in decompensated heart failure HRC – Project 435,084

2008 Prof Evan Begg Free drug metabolic clearance in older adults HRC – Project 326,365

2008 Prof Mark Richards Cardioendocrine Research group funding Cardioendocrine 240,000 Research Trust

2008 Prof Timothy Anderson Research Fellowship for Dr Michael MacAskill Van der Veer Institute 176,774

2008 Dr Christopher BNP signal peptide: a novel specific marker of HRC – Project 159,224 Pemberton acute cardiac injury

2008 Dr Miriam Rademaker The role of prorenin and its receptor in National Heart cardiovascular disease Foundation Project 155,000

2008 Dr Richard Gearry A novel cellular assay system to assess the Broad Medical 152,747 potential role of Mycobacterium avium subsp. Research Program paratuberculosis in the development and progression of Crohn’s disease

2008 Prof Mark Richards Echocardiography machine (Ultrasonography Canterbury Medical 100,000 equipment) Research Foundation

2008 Dr Timothy Prickett Plasma NtproCNP as a marker of skeletal growth Canterbury Medical 65,869 Research Foundation

2008 Dr Michael Epton Relationship between nutrition and childhood Canterbury Medical 61,777 asthma (Infant Cohort Study) Research Foundation

2008 A/P Bridget Robinson Coagulation and Cancer – Research Fellowship Lloyd Morgan Lions 59,980 Clubs Charitable Trust

74 RESEARCH REPORT 2007/2008 2007 Dr Christopher BNP signal peptide: a novel, specific marker of HRC – Project 666,467 Pemberton acute cardiac injury

2007 A/P Murray Barclay Interactive Medicine Project TEC Innovation & 346,554 Development Fund

2007 Jessica Lin Real-Time Model-based Diagnosis of Sepsis NZ Science & Technology 252,200 Clinical Development of Metabolic Markers Postdoctoral Fellowship

2007 Dr Nicola Scott A mouse model of the human metabolic National Heart 180,000

syndrome Foundation UOC

2007 A/P Christopher Inhibition of cardiac sympathetic nerve activity: National Heart 176,179 Charles novel therapies post-myocardial infarction Foundation Project

2007 Prof Mark Richards Regional secretion and clearance of novel National Heart 155,340 peptides in health and heart disease Foundation Project

2007 Dr Timothy Prickett C-type natriuretic peptide: a key mediator of Lottery Health Research 121,173 bone formation?

2007 A/P Timothy Yandle Bio-plex immunoassay system for multiple Lottery Health Research 114,162 simultaneous immunoassays

2007 Prof Zoltan Endre Reversing the effects of diabetes on the kidney Lottery Health Research 105,054

2007 Prof Evan Begg Free drug metabolic clearance in the elderly Lottery Health Research 94,464

2007 Dr Leigh Ellmers Effect of chronic Urocortin 2 treatment following National Heart 92,595 experimental myocardial infarction Foundation Project

2007 A/P Bridget Robinson Breast cancer stem cells: hypoxia and angiogenesis Genesis Oncology Trust 77,485

2007 Prof Gary Nicholls, Natriuretic peptides in end-stage renal failure Canterbury Medical 74,562 Dr Tim Prickett Research Foundation

2007 Dr Leigh Ellmers Effect of chronic Urocortin 2 treatment following Canterbury Medical 74,478 experimental myocardial infarction Research Foundation

2007 Prof Timothy Saccadic biomarkers in Parkinson’s disease Canterbury Medical 74,394 Anderson Research Foundation

2007 Prof Timothy Saccadic function in Alzheimer’s disease: NZ Neurological 68,166 Anderson an fMRI study Foundation

2007 Dr Barry Palmer Polymorphic variants of x-linked genes in heart Canterbury Medical 66,983 disease Research Foundation

2007 Dr Anna Pilbrow Genotype and gene expression in heart failure National Heart 63,199 using Affymetrix technology Foundation Project

Total $7,195,046

Total for all grants ≤ $50,000 awarded in 2007-8 $487,900

Total for all grants active in 2007-8 but awarded prior to 2007 $13,447,734

Grand total $21,130,680 * GST exclusive

Division of HEALTH SCIENCES 75 Research Contracts

Year Approved Organisation

2007-2008 Quintiles Pty Limited Syft Limited Clinical Network Services (CNS) Pty Ltd Quintiles Pty Limited Health New Zealand Ltd

UOC Total $768,273

Postgraduate Students

Total Head Count* 2007 2008

PhD 19 19 Masters† 2 0

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Prof Mark Richards University of Otago Distinguished Research Medal

2008 Prof Mark Richards Royal Society of New Zealand Sir Charles Hercus Medal

2008 Prof Mark Richards Nominated to Fellowship of the Royal College of Physicians, UK

2008 A/Prof Chris Frampton Gold Medal for Research Excellence, UOC

2008 Dr Jessica Lin FRST New Zealand Science and Technology Post-doctoral Fellowship

2008 Dr Richard Gearry Don Beaven Travelling Fellow

2007 Prof Evan Begg ASCEPT Teaching Excellence Award

2007 Prof Eric Espiner Gold Medal for Research Excellence, UOC

2007 Prof Gary Nicholls Gold Medal for Research Excellence, UOC

2007 Dr Chris Pemberton HRC Sir Charles Hercus Research Fellowship

2007 Sasksia van Stockum TEC Bright Future Top Achiever Doctoral Scholarship

2007 Dr Richard Gearry Olympus New Zealand Society of Gastroenterology Travelling Fellow

2007 Dr Sharon Gardiner Exceptional PhD thesis, University of Otago

2007 Dr Sharon Gardiner Denis Wade Johnson & Johnson New Investigator Award

76 RESEARCH REPORT 2007/2008 DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Acting Head of Department: Dr Peter Sykes. Email: [email protected]

The Department of Obstetrics and Gynaecology has a number of established research projects in progress which are funded from a variety of sources. The main themes are maternal and fetal medicine, gynaecological cancer; reproductive steroids in cardiovascular disease; and endocrine regulation of reproduction.

Website: http://www.chmeds.ac.nz/departments/obstetrics/index.htm UOC Major Areas of Research Strength

Maternal and fetal medicine Research covers both maternal and fetal health and outcomes. One area of research interest is database development. Ongoing data is collected for the (i) Fetal Medicine Clinical Unit which reviews women with complicated fetal problems or those at risk for them, and the (ii) Maternal Medical Clinic where women with underlying medical problems attend. This enables both audit and follow up of specific cases. Investigations into preeclampsia are underway. These focus on prediction of outcome (mother and neonate), and assessment of proteinuria as a screening/diagnostic test. Researchers also participate in a variety of multicentre clinical trials.

Cell and protein regulation The theme of the Laboratory for Cell and Protein Regulation’s research is the characterisation of the communities of chemical factors that make up physiological systems and to describe the dynamic interactions that occur. The laboratory studies endometrial cancer; reproductive endocrinology; and vasoactive peptides of the vascular endothelium.

Website: http://www.chmeds.ac.nz/departments/obstetrics/research.htm

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Peter Sykes Pilot study to assess feasibility and cost benefit RANZC of 6,000 of HPV testing eight women with HGSIL Obstetricians & Gynaecologists- Mercia Barnes Trust

2007 Dr Peter Sykes Gynaecological Cancer Research Genesis Oncology Trust 22,822

2007 Prof John Evans Travel grant from MacDiarmid Institute MacDiarmid Institute 5,128

Total $33,950

Total for all grants ≤ $5,000 awarded in 2007-8 $6,200

Total for all grants active in 2007-8 but awarded prior to 2007 $142,971

Grand total $183,121 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 University of British Columbia New Zealand Centre for Reproductive Medicine Ltd

Total $157,320

Division of HEALTH SCIENCES 77 Postgraduate Students

Total Head Count* 2007 2008

PhD 3 3 Masters† 1 1

* as at 1 June each year † thesis or dissertation students only UOC Awards and Scholarships

Year Researcher Award/Scholarship

2007 Gloria Evelyn Evans TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

DEPARTMENT OF ORTHOPAEDIC SURGERY AND MUSCULOSKELETAL MEDICINE

Head of Department: Associate Professor Gary Hooper. Email: [email protected]

The Department of Orthopaedic Surgery and Musculoskeletal Medicine is unique in New Zealand in that both the Academic and Service Departments are combined so that the surgical and medical components of musculoskeletal diseases and injuries come under the roof of one department.

Website: http://www.chmeds.ac.nz/departments/orthopaedics/research.htm

Major Areas of Research Strength

Tissue engineering Tissue engineering strategies which aim to combine a patient’s own cells, biodegradable scaffolds and growth factors may offer considerable advantages over current surgical interventions used to repair or regenerate damaged tissues following trauma or disease. This is the focus of the Christchurch Orthopaedic Tissue Engineering and Regenerative Medicine Research Group (CO-TERM). Areas of particular research interest include: orthopaedic biomechanics – total joint replacement and medical device design; tissue engineering and regeneration of cartilage, bone and neural/spinal cord; advanced scaffold design and bio- manufacturing; biomaterials engineering; dynamic mechanical analysis of porous materials; and novel metal alloys for bone interfacing implants.

Prospective clinical outcome studies Studies underway are mainly long term prospective outcome studies on various types of total joint replacements. In addition, the Department is responsible for the National Joint Replacement Register. This Register was established in 1998 by the New Zealand Orthopaedic Association to record technical information about total hip and knee surgery performed in New Zealand. The register has since been expanded to include all total shoulder, elbow and ankle procedures, as well as unicompartmental knees and all primary and revision hips.

Reconstructive upper limb surgery for tetraplegia Reconstructive surgery for tetraplegia has been carried out at the Spinal Injuries Unit at Burwood Hospital since 1982. The Unit is now one of the leaders in the world, not only for the surgery itself but also for outcome studies including the development of new surgical procedures. An active research programme includes studies into: changes in tendon length during postsurgical rehabilitation; development of a device for accurate measurement of joint torque; patterns of shoulder motion; and wheelchair kinematics.

78 RESEARCH REPORT 2007/2008 External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Tim Woodfield Alternative cartilage tissue engineering strategies Canterbury Medical 74,579 adopting smart scaffold design and perfusion Research Foundation bioreactors

2008 Dr Tim Woodfield Alternative cartilage tissue engineering strategies Canterbury Orthopaedic 62,199

Services Trust UOC

2008 Dr Tim Woodfield Funding for orthopaedic research Canterbury Orthopaedic 18,018 Services Trust

2008 Dr Tim Woodfield Funding for orthopaedic research Canterbury Orthopaedic 12,888 Services Trust

2007 Prof Alastair Rothwell Funding for musculoskeletal research Canterbury Orthopaedic 33,937 Services Trust

2007 Prof Alastair Rothwell Funding for musculoskeletal research NZ Spinal Trust 25,996

2007 Dr Tim Woodfield Cartilage tissue engineering using smart scaffold Wishbone Trust 19,500 design and advanced bio-manufacturing

Total $247,117

Total for all grants active in 2007-8 but awarded prior to 2007 $82,626

Grand total $329,743 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD - - Masters† 1 1

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 79 DEPARTMENT OF PAEDIATRICS

Head of Department: Professor Brain Darlow. Email: [email protected]

The Department of Paediatrics has an active research programme. Long-established research interests include paediatric urology especially reflux, community child health, sudden infant death syndrome, and neonatal research. More recently the Department has developed research interests in free radicals, respiratory medicine and cancer genetics.

Website: http://www.chmeds.ac.nz/research/dgrg/index.htm UOC Major Areas of Research Strength

Neonatology The Cure Kids Chair in Paediatric Research is held in the Department. Research interests concern the care of newborn, sick and premature babies, including trying to identify the causes of health problems associated with premature birth and ways to prevent them. Follow-up studies of the health outcomes of extremely premature infants are also carried out. A specific interest is free radical disease in the newborn.

Childhood cancer The Children’s Cancer Research Group is working on a variety of projects, from the basic biology of cancer in children, to the complex long-term effects of its treatment. Researchers are interested in the biology and genetics of childhood solid tumours. Current projects involve investigating the molecular genetics of neuroblastomas and hepatoblastomas using microarray gene expression technology, tissue arrays and protein analysis. More specifically, projects are underway to investigate the role of histone methylation and DNA methylation in both neuroblastoma and hepatoblastoma, and the role of the sonic hedgehog developmental pathway in paediatric solid tumours.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Brian Darlow Follow-up of a New Zealand national cohort of Child Health Research 100,000 very low birthweight infants at 22 years of age Foundation

2008 Prof Brian Darlow Does high or low oxygen saturation targeting in Child Health Research 99,560 infants of less than 28 weeks gestation influence Foundation grey and white matter damage as seen on cranial MRI scans at term equivalent?

2007 Dr Michael Sullivan Epigenetic mechanisms in the pathogenesis of Child Cancer Foundation 240,000 cancer: neuroblastoma as a model

Total $439,560

Total for all grants ≤ $50,000 awarded in 2007-8 $79,768

Total for all grants active in 2007-8 but awarded prior to 2007 $1,359,982

Grand total $1,879,310 * GST exclusive

80 RESEARCH REPORT 2007/2008 DEPARTMENT OF PATHOLOGY

Head of Department: Professor David Murdoch. Email: [email protected]

The Department of Pathology is one of the largest and most research intensive departments at the University of Otago, Christchurch. Research groups within the Department include: the Free Radical Research Group (FRRG); the Cancer Genetics Research Group; the Gene Structure and Function Laboratory; the Angiogenesis Research Group (ARG); the Christchurch Haematology Research Group; the Liver Sieve Research Group; the Christchurch Microbial Research Group; and the Breath Research Group. The Department also hosts the Carney Centre for Pharmacogenetics.

Website: http://www.chmeds.ac.nz/departments/pathology/index.htm UOC

Major Areas of Research Strength

Free radical research Free radical research, carried out in the Free Radical Research Group (FRRG) is one of the Pathology Department’s major research interests. The FRRG consists of biochemists and cell biologists undertaking a range of interrelated research projects on aspects of oxidative stress and antioxidant action. Current areas of research include oxidant production by neutrophils; mechanisms and consequences of thiol protein oxidation; redox regulation of cell signalling; oxidative stress and apoptosis; radical scavenging mechanisms and reactions of superoxide radicals. The group has an active programme of developing biomarker assays for specific oxidants and applying them to investigating oxidative injury in disease. Collaborative clinical projects include investigations of the role of oxidants in lung disease and brain injury in premature infants, cystic fibrosis, asthma and neurodegenerative diseases.

Website: http://www.chmeds.ac.nz/research/freerad/aboutus.htm

Cancer research Cancer research in the Department is undertaken by two groups.

The Cancer Genetics Research Group: the focus of research is the cytogenetic and molecular genetic basis of human cancer. The aims of the Group are to: identify new gene alterations which are relevant to the cause and/or progression of cancer; to develop a better understanding of the molecular mechanisms that determine gene rearrangements in cancer cells; and to actively translate current research knowledge in these fields to clinical diagnosis.

Website: http://www.chmeds.ac.nz/research/cancergenetics/index.htm

The Angiogenesis Research Group: this Group is investigating the biology of human tumours with a focus on the molecular regulation of blood (angiogenesis) and lymphatic vessel formation (lymphangiogenesis) and function during human tumour growth and metastasis. Specific research interests include: expression and regulation of angiogenic factors in human cancers; effects of the tumour microenvironment on tumour angiogenesis; targeting tumour endothelium; links between cancer, inflammation, and thrombosis; ethnicity and cancer biology; metabolism, insulin resistance and chronic low-grade inflammation in cancer biology; and skin cancers in immune-suppressed renal transplant recipients.

Website: http://www.chmeds.ac.nz/research/angiogenesis/index.htm

Gene structure and function Much of the current research centres on the areas of psychiatric genetics and pharmacogenetics (the impact of genetic variation on responses to drugs) and is carried out within the Gene Structure and Function Laboratory. The laboratory’s psychiatric genetics research is a collaboration with Professor Peter Joyce in the Department of Psychological Medicine. Expertise includes gene structure and expression analysis, polymorphism detection (via DHPLC), development and application of genotyping assays, tissue culture including the manipulation of mouse embryonic stem cells, proteomics, microarray analysis, and rodent genetics.

Website: http://www.chmeds.ac.nz/research/gsfl/index.htm

Molecular Pathology and Infectious Diseases Research An active research program complements the clinical diagnostic side of Molecular Pathology. The focus of the group’s research falls on the identification and characterisation of abnormalities of human proteins that are associated with disease. Topics include: structure and function relationships of fibrinogen; methods to stabilise proteins; and development of methods to detect variants at the DNA and protein levels. Infectious Disease research is a growing strength of the Department. Areas of specific interest include Tb, endocarditis and hospital-acquired infections.

Division of HEALTH SCIENCES 81 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Christine Neutrophil Oxidants in Infection and HRC – Project 1,588,081 Winterbourn Inflammation

2008 Dr Mark Hampton Peroxiredoxins in antioxidant defence and HRC – Project 1,520,053 cell signalling UOC 2008 Dr Mark Hampton, Deciphering the role of peroxiredoxins in the Marsden Fund Project 855,000 Prof Christine cellular response to oxidative stress Winterbourn

2008 Dr Martin Kennedy Copy number variants of the human dopamine Marsden Fund Project 816,000 D4 receptor gene: new light on an old question

2008 Dr Rebecca Roberts Genetics of susceptibility and management in HRC Sir Charles 499,999 inflammatory bowel disease Hercus Research Fellowship

2008 Dr Rebecca Roberts Novel genetic risk factors for inflammatory HRC – Project 317,745 bowel disease

2008 Dr Ursula Jewell Identification of new genetic changes in acute Cancer Society Project 194,320 lymphocytic leukaemia

2008 Dr Ursula Jewell GenePix autoloader 4200AL microarray scanner Lottery Health Research 165,000

2008 Dr Ursula Jewell Spotting hidden genetic changes in leukaemia by Lottery Health Research 120,000 high-resolution microarray profiling

2008 Dr Mark Hampton Probing the molecular targets of isothiocynates Cancer Society Project 115,550

2008 Prof Christine National Research Centre for Growth and National Research 92,107 Winterbourn Development Centre for Growth and Development

2008 Dr Rebecca Roberts Copy number polymorphisms as risk factors for Lottery Health Research 91,463 inflammatory bowel disease

2008 A/P Martin Kennedy Carney Centre for Pharmacogenomics Trustees of the UoO 64,784 Foundation Trust

2007 Prof Christine Radical targets of superoxide toxicity Marsden Fund Project 733,331 Winterbourn, A/P Tony Kettle

2007 A/P Martin Kennedy Carney Centre for Pharmacogenetics Trustees of the UoO 165,179 Foundation Trust

2007 Dr Margreet Vissers Myeloperoxidase-derived oxidants and apoptosis: HRC 122,029 HRC Fellowship Bridging Support Grant

2007 Prof Stephen Diagnosis of pseudomonas aeruginosa by Lottery Health Research 78,889 Chambers breath testing

2007 Dr Margreet Vissers A new role for Vitamin C: control of the hypoxic Canterbury Medical 69,851 response in cancer cells Research Foundation

82 RESEARCH REPORT 2007/2008 2007 A/P Christine Morris Molecular pathology of breast cancer translational Cancer Society Project 60,000 to diagnosis

Total $7,669,381

Total for all grants ≤ $50,000 awarded in 2007-8 $325,592

Total for all grants active in 2007-8 but awarded prior to 2007 $4,012,935

Grand total $12,007,908 UOC * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 AstraZeneca Ltd Zespri International Limited University of Auckland Otago Innovation Limited New Zealand Institute of Food & Crop Research Atkins Ltd

Total $1,279,799

Postgraduate Students

Total Head Count* 2007 2008

PhD 24 21 Masters† 3 5

* as at 1 June each year † thesis or dissertation students only and includes MMLabSc students

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Prof Christine Trevor Slater Award, International Society for Free Radical Research Winterbourn

2008 Dr Mark Hampton Invitrogen Life Sciences Award for Emerging Excellence in Molecular Biology Research in New Zealand

2008 Caroline Kuiper TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

2008 Michele Hunt New Zealand Society for Oncology Eli Lilly Award (PhD student)

2008 Michele Hunt Postgraduate Tassell Scholarship in Cancer Research (PhD student)

2008 Dr Mona Syhre, Prof Otago Innovation Proof of Concept Award Steve Chambers

2008 Katarzyna MacKenzie Canterbury Medical Research Foundation Fellowship

Division of HEALTH SCIENCES 83 2007 Dr Rebecca Roberts University of Otago Early Career Award for Distinction in Research

2007 Dr Rebecca Roberts Sir Charles Hercus Research Fellowship, Health Research Council

2007 Ekaterina Volkova TEC Bright Future Top Achiever Doctoral Scholarship (PhD Student)

2007 Ekaterina Volkova New Zealand Society for Oncology Pfizer Award (PhD Student)

UOC 2007 Sarah Deng TEC Bright Future Top Achiever Doctoral Scholarship (PhD Student)

2007 Dr Margaret Currie University of Otago, Top Achiever Doctoral Scholarship Supervisor Award

2007 Campbell Sheen Millennium Science Award, Queenstown Molecular Biology Meeting (PhD Student)

2007 Campbell Sheen Biochemical Journal Young Investigator Award (PhD Student)

2007 Sarah Gunningham Division of Health Sciences Career Development Post-doctoral Fellowship (PhD Student)

DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Roger Mulder. Email: [email protected]

The Department of Psychological Medicine is one of the largest Departments at the University of Otago, Christchurch and has a very active research programme. The Department hosts a number of research groups including: the Christchurch Health and Development Study (CHDS); The Canterbury Suicide Project; The Mental Health Clinical Research Unit (MHCRU); and The National Addiction Centre (NAC).

Website: http://www.uoc.otago.ac.nz/departments/psychmed/index.htm

Major Areas of Research Strength

Lifecourse research The Christchurch Health and Development Study (CHDS) has been in existence for more thirty years. During this time it has followed the health, education and life progress of a group of 1,265 children born in the Christchurch urban region during mid 1977. This cohort has now been studied from infancy into childhood, adolescence and adulthood. Research projects in this study span a wide range of disciplines including psychology, psychiatry, epidemiology, paediatrics, health economics and sociology.

Website: http://www.chmeds.ac.nz/research/chds/index.htm

Mental health research The Mental Health Clinical Research Unit (MHCRU) is involved in studies on depression, bipolar affective disorder, bulimia nervosa and anorexia nervosa. Future studies are also likely on social anxiety disorders. Current studies include a psychotherapy treatment trial in depression, a psychotherapy trial in people with bipolar disorder, a comparison of three psychotherapies for binge eating, and a study on the genetics of depression and personality.

Website: http://www.chmeds.ac.nz/departments/psychmed/clinical.htm

Suicide The Canterbury Suicide Project is a research project into suicidal behaviour in people of all ages. The project was initiated in 1991 and major research interests include: youth, adult and older adult suicide, risk and protective factors in suicidal behaviour, suicide prevention, the impact of suicide on close family members, national suicide prevention strategies, and restriction of access to methods of suicide.

Website: http://www.chmeds.ac.nz/research/suicide/index.htm

84 RESEARCH REPORT 2007/2008 Addiction research The National Addiction Centre (NAC) is dedicated to developing and promoting effective interventions for people with alcohol, drug and addiction related problems in Aotearoa New Zealand. Ongoing research projects include: Naturalistic Treatment Outcome Study - Five Year Follow-up; Youth Retention Study; Odyssey Youth Outcome Study; The Effectiveness of Naltrexone in Reducing the Craving of People with Pathological Gambling; Experiences and Needs of Mäori Methadone Maintenance Treatment Patients; Resilience in Indigenous Health Networks; Development of Mäori AOD Services and Workforce in Aotearoa New Zealand; Nicotine Maintenance Feasibility Trial; Pre-quit Nicotine Replacement Therapy Trial; and The Alcohol and Drug Outcomes Project (ADOPT) – Part II.

Website: http://www.chmeds.ac.nz/departments/psychmed/treatment/index.html UOC

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Simon Adamson An evaluation of the Moana House therapeutic Alcohol Advisory 219,827 community programme Council of NZ

2008 A/P Marie Crowe The Clinical Effectiveness of Specialist Supportive Strategy to Advance 92,586 Care for Patients with Bipolar Disorder Research under TEC

2008 Prof Peter Joyce A pilot study to determine the feasibility of a Canterbury Community 50,000 longitudinal study on healthy ageing in Canterbury Trust

2007 Prof David Fergusson Longitudinal Studies of Mental Health and HRC Programme 3,806,011 Psychosocial Wellbeing Extension

2007 Prof Peter Joyce Mental Health Clinical Research HRC Programme 3,345,053 Extension

2007 Prof Douglas Sellman Treatment evaluation of alcohol and mood HRC – Project 850,859 (TEAM) Study

Total $8,364,336

Total for all grants ≤ $50,000 awarded in 2007-8 $32,093

Total for all grants active in 2007-8 but awarded prior to 2007 $5,155,348

Grand total $13,551,777 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Te Rau Matatini (Trust) Ministry of Health Clinical Advisory Services Aotearoa

Total $1,480,417

Division of HEALTH SCIENCES 85 Postgraduate Students

Total Head Count* 2007 2008

PhD 17 10 Masters† 1 2

* as at 1 June each year † thesis or dissertation students only UOC Awards and Scholarships

Year Researcher Award/Scholarship

2008 A/P Annette Beautrais American Foundation for Suicide Research Award

2007 Katie Douglas TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

2007 Prof Roger Mulder Royal Australian and New Zealand College of Psychiatrists, Organon Senior Research Award

2007 Prof David Fergusson Honorary Fellowship of the Royal Australasian College of Physicians

Professor David Fergusson, Director of the Christchurch Health and Development Study

86 RESEARCH REPORT 2007/2008 DEPARTMENT OF PUBLIC HEALTH AND GENERAL PRACTICE

Head of Department: Professor Les Toop. Email: [email protected]

The joint department is unique in New Zealand in that it brings together Public Health and General Practice/Primary Care teaching and research groups.

Website: http://www.uoc.otago.ac.nz/departments/pubhealth/dphgpsplit.htm

Major Areas of Research Strength UOC

General practice research The Christchurch General Practice Research Group focuses on clinical research, where the results can be directly translated into clinical practice. The two central research themes underpinning this are rational use of medicines and innovative models of primary care. Current research projects include: the Infant Iron Study; the Antibiotic Resistance Monitoring Study; the Chlamydia Study; and the Selective Serotonin Reuptake Inhibitor (SSRI) Study. The latter study investigates the maintenance versus gradual withdrawal of fluoxetine in stable primary care depression and is funded by the Health Research Council.

Website: http://www.uoc.otago.ac.nz/departments/genprac/research.htm

Public health research Public health is the study and practice of preventing disease, prolonging life and promoting the health of the population through the organised efforts of society. Research by the Public Health Research Group is carried out in the following areas: epidemiology, including colorectal cancer and mental health in New Zealand; health services; health policy; health determinants; Mäori health; and methodological advances.

Website: http://www.uoc.otago.ac.nz/departments/pubhealth/research.htm

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Patrick Graham Improving the analysis of product vigilance HRC Partnership 99,823 databases Programme

2007 Dr Patrick Graham, Colorectal cancer control in New Zealand HRC – Project 1,443,518 Prof Ann Richardson

2007 Suzanne Pitama The Mäori Community Heart Study – National Heart 129,528 non-Mäori cohort Foundation Project

Total $1,672,869

Total for all grants ≤ $50,000 awarded in 2007-8 $1,500

Total for all grants active in 2007-8 but awarded prior to 2007 $8,778,589

Grand total $10,452,958 * GST exclusive

Division of HEALTH SCIENCES 87 Research Contracts

Year Approved Organisation

2007-2008 Ministry of Health New Zealand Guidelines Group Inc ACC Counties Manakau District Health Board Auckland District Health Board

UOC Total $229,032

Postgraduate Students

Total Head Count* 2007 2008

PhD 3 9 Masters† 12 15

* as at 1 June each year † thesis or dissertation students only

DEPARTMENT OF RADIOLOGY

Head of Department: Professor Tim Buckenham. Email: [email protected]

The Department of Radiology has a small but active research programme. Recent research projects include: the development of a national thoracic stent database to collect and assess data from all implants performed in New Zealand; the development of new detectors that have applications in medical imaging; and investigations of clinical outcomes in infants with renal pelvis dilatation.

Website; http://www.chmeds.ac.nz/departments/radiology/index.htm

Major Areas of Research Strength

Aneurysm repair Research seeks to evaluate the safety and efficacy of new devices and techniques in interventional radiology.

Research Contracts

Year Approved Organisation

2008 University of Canterbury

Total $80,000

Awards and Scholarships

Year Researcher Award/Scholarship

2007 Dr Anthony Butler Bill Hare Fellowship

2007 Dr Anthony Butler GE Medical Systems Prize and Siemens Medical Systems Prize

88 RESEARCH REPORT 2007/2008 DEPARTMENT OF SURGERY

Head of Department: Professor Frank Frizelle. Email: [email protected]

Major research interests in the Department of Surgery are Helicobacter, SYFT technology, colorectal, laparoscopic surgery, dendritic cell research, and vascular research. Another focus is in the Developmental Genetics Research Group, working in collaboration with Paediatrics.

Website: http://www.chmeds.ac.nz/research/helicobacter/index.htm UOC Major Areas of Research Strength

Helicobacter pylori A range of projects relating to Helicobacter infection in humans are being carried out by the Helicobacter Research Group. Current research centres on the gastric pathogen, Helicobacter pylori and the role that small outer membrane vesicles shed from the bacterial surface play in the development of Helicobacter pylori-associated disease, including gastric cancer. Investigations into the use of common foods to ameliorate Helicobacter pylori-associated gastric inflammation are ongoing. The link between the presence of Helicobacter pylori and inflammatory bowel disease, a precursor for colon cancer is also being studied. Investigations of Mycobacterium avium subsp. paratuberculosis in the aetiology and pathogenesis of Crohn’s disease are also underway.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Francis Frizelle Funding for Senior Lecturer Merck & Co 225,527

2008 Dr Katarzyna Why are skin cancers more aggressive in renal Canterbury Medical 127,000 MacKenzie transplant patients? Research Foundation

2008 Dr Jacqui Keenan Bacterial vesicles as initiators of colorectal cancer Lottery Health 79,668

2007 Prof Justin Roake The convergence study Research Trust of 202,647 Victoria University

2007 Dr Jacqui Keenan Do Helicobacter pylori outer membrane vesicles Robert McClelland 61,227 compromise the integrity of gastric epithelial cells? Trust

Total $696,069

Total for all grants ≤ $50,000 awarded in 2007-8 $85,592

Total for all grants active in 2007-8 but awarded prior to 2007 $620,540

Grand total $1,402,201 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 New Zealand Institute of Crop & Food Research

Total $90,411

Division of HEALTH SCIENCES 89 Postgraduate Students

Total Head Count* 2007 2008

PhD 2 2 Masters† 2 2

* as at 1 June each year † thesis or dissertation students only

UOC Awards and Scholarships

Year Researcher Award/Scholarship

2008 Mr Timothy Eglington Association of Coloproctology of Great Britain and Ireland Travelling Fellowship Award

2007 A/P Philip Bagshaw The North & South Magazine’s New Zealander of the Year (see North & South, January 2008, Issue 262).

CENTRE FOR POSTGRADUATE NURSING STUDIES

Director of Centre: Ms Beverley Burrell. Email: [email protected]

Website: http://www.chmeds.ac.nz/departments/pgradnursing/index.htm

Major Areas of Research Strength

Management of long-term conditions The focus of this research theme is the development of evidence-based healthcare to minimise the impact of chronic health needs on people’s lives. Research explores symptom experience, risk assessment, preventative care and symptom control issues, with particular emphasis on the enhancement of patient self-management strategies. The study of chronic health needs encompasses a broad spectrum of disease and age groups to include children, families and older people. Ongoing projects include the assessment and management of chronic fatigue syndrome, families of patients with heart conditions and cancer survivors.

Health status and outcomes over the lifecourse Research efforts focus on the distribution and cause of a disease, illness or risk factor. Studies examine how many people have a disease, illness or risk factor, the outcome of these (recovery, death, disability etc), and the factors that influence the distribution and outcome of the disease, illness or risk factor. Research activities address: prevalence and incidence of symptoms; epidemiology; aetiology and innovative management of chronic disease; lay efforts to reduce health inequalities; evaluation of prevention programmes e.g. those tackling obesity, diabetes etc; health of vulnerable groups in urban and rural areas; and impact assessments by health professionals.

Service delivery and health Research centres around the comparative safety, effectiveness, cost-effectiveness and acceptability of methods of providing health and social care intended to improve outcomes or experience for patients or clients. This group seeks to inform and evaluate the impact of health policy through empirical research and the synthesis of research evidence. Researchers assess innovative approaches to learning and education both to support practitioners and to develop practice in health and social care.

90 RESEARCH REPORT 2007/2008 External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Lisa Whitehead Factors impacting on family centred care for TEC BRCSRA Fund 75,000 children

Total $75,000

Total for all grants active in 2007-8 but awarded prior to 2007 $26,778 UOC

Grand total $101,778 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD - - Masters† 12 20

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr Lisa Whitehead University of Otago Early Career Award for Distinction in Research

2008 Virginia Jones Strategy to Advance Research in Nursing (STAR Award) (Masters student)

2007 Tenisia Hager Pacific Health Research Masters Award (Masters student)

Division of HEALTH SCIENCES 91 UNIVERSITY OF OTAGO, WELLINGTON

DEPARTMENT OF MEDICINE

Head of Department: Professor Carl Burgess. Email: [email protected]

The Department of Medicine is active in many areas of medical research including disease mechanisms, new treatments and clinical trials of treatments. The Department comprises three major research groups which are reflected in the major areas of research strength detailed below.

UOW Website: http://www.wnmeds.ac.nz/academic/Med/index.html

Major Areas of Research Strength

Rehabilitation Research into the process and outcomes of rehabilitation is conducted at the Rehabilitation, Teaching and Research Unit (RTRU). Research is aimed at improving the quality of life of people with disabilities in New Zealand. Specific interests include Parkinson’s disease, gout, rheumatoid arthritis, stroke, brain injuries, lower back pain, schizophrenia, spinal cord injury, diabetes and incontinence. A recent key systematic review of over 6000 women has revealed that women who receive one-on-one instruction on pelvic floor muscle exercises from a health professional are less likely to suffer incontinence during or after pregnancy.

Website: http://www.wnmeds.ac.nz/academic/Med/Rehab/index.html

Asthma The Wellington Asthma Research Group’s (WARG’s) research programme covers clinical, biomedical and public health aspects of asthma research, including studies to understand the causes of asthma and also the study of novel treatments. The objectives of the Group centre on identifying the causes of asthma, the factors that determine severity, and the development of strategies for prevention and improved management. In recent times, key studies by the Group have shown that endotoxins in the home are associated with wheezing and skin rashes in a large sample of infants under 15 months of age. An additional two year study has shown that use of a probiotic supplement significantly reduces the rate of childhood eczema in infants under two. A new HRC project is looking at the health effects of long-term exposure to hydrogen sulphide gas.

Website: http://www.wnmeds.ac.nz/academic/Med/warg/index.html

Sleep disorders Sleep research is the focus of WellSleep, a sleep investigation centre which provides diagnostic and treatment for a variety of different sleep disorders including sleep apnoea, nocturnal hypoventilation, periodic limb movements during sleep, narcolepsy, and parasomnias. The centre also conducts research into a variety of sleep disorders. Recent research topics include: the effects of warm air humidification on nasal CPAP compliance in obstructive sleep apnoea; a pilot study of the impact of sleep disorders in road traffic accidents; the effectiveness of a mandibular advancement splint in treating mild obstructive sleep apnoea and snoring; polysomnographic studies of sleep and respiration; and effects of position in pre-term infants.

92 RESEARCH REPORT 2007/2008 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr William Taylor A feasibility study of structural means of eliciting HRC 149,734 goals in rehabilitation

2008 Prof Carl Burgess Electronic pharmacovigilance using a centralised HRC Partnership 100,026 database linking general practice data Programme UOW 2007 Ms Bernadette Jones Pukapuka Hauora: Mäori Parents’ Experiences HRC – Project 624,418 Managing a Child with Asthma

2007 Prof Julian Crane Effects of long-term low level hydrogen sulfide NIH 393,108 exposure. H2S absorption in Rotorua

2007 Dr Tristram Ingham The Role of Vitamin D in the Severity of Lottery Health Research 170,107 Bronchiolitis

Total $1,437,393

Total for all grants ≤ $50,000 awarded in 2007-8 $76,911

Total for all grants active in 2007-8 but awarded prior to 2007 $1,801,092

Grand total $3,315,396 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Zespri International Limited Fonterra Research Centre Ltd Covance Pty Ltd (Roche) Industrial Research Ltd Rex Medical Limited LactoPharma Meracol Corporation Ltd Vital foods Green Edge Limited Nga Uri o Te Ngahere Trust Alchemia Ltd Otago Innovation Ltd Seperex Ltd Xoma (US) LLC Waitakere Holdings Ltd Aroma New Zealand Ltd Open Polytechnic of New Zealand

Total $1,981,291

Division of HEALTH SCIENCES 93 Postgraduate Students

Total Head Count* 2007 2008

PhD 15 16 Masters† 11 11

* as at 1 June each year † thesis or dissertation students only UOW Awards and Scholarships

Year Researcher Award/Scholarship

2007 Rob Siebers Fellow of the Institute of Biology London (FIBiol)

DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Head of Department: Professor Kevin Pringle. Email: [email protected]

Research interests in the Department of Obstetrics and Gynaecology are varied and include renal dysphagia, hydronephrosis, prenatal diagnosis and therapy, endometriosis, incontinence following delivery, perinatal outcomes following caesarean section, fertility, assisted reproductive techniques, perinatal pathology, and sudden infant death syndrome.

Website: http://www.wnmeds.ac.nz/academic/OandG/index.html

External Grants

Total for all grants active in 2007-8 but awarded prior to 2007 $69,276

DEPARTMENT OF PAEDIATRICS AND CHILD HEALTH

Head of Department: Dr Thorsten Stanley. Email: [email protected]

The members of the Department of Paediatrics and Child Health are committed to conducting high quality research into common and important childhood diseases and to ensure the knowledge gained is translated into improved adolescent and child health outcomes. Current research focuses on paediatric infectious disease, cystic fibrosis, bronchiectasis, vascular complications of diabetes, hypoglycaemia, sleep deprived EEGs and childhood epilepsy, respiratory control in newborn babies and preterm infants, sexual assault, childhood asthma and the influence of probiotics upon gut permeability, and the development of eczema.

Website: http://www.wnmeds.ac.nz/academic/paediatrics/index.html

Major Areas of Research Strength

Epilepsy The epilepsies are a common group of disorders. A significant proportion of them are inherited and due to genetic factors. The Wellington Epilepsy Research Group, under the direction of Dr Sadleir, is undertaking research aimed at further delineation of the clinical features and genetics of epilepsies found in families, and identifying genes for these epilepsies. Finding new epilepsy syndromes and the genes responsible for these will allow more accurate diagnosis and prognosis, and lead to novel improved therapies. Dr Sadleir and Dr Wiltshire are also involved in a project assessing vascular function in children on anticonvulsant medications. Adults with epilepsy have been shown to have a three-fold increase in cardiovascular death. Anticonvulsant medications in children are associated with hyperhomocysteinaemia, a known risk factor for endothelial dysfunction and subsequent atherosclerosis. The present research aims to identify early vascular disease in children with epilepsy receiving anticonvulsants.

94 RESEARCH REPORT 2007/2008 Sleep and breathing The department is collaborating with colleagues in the Department of Surgery and Anaesthesia on research into measures of respiratory variability and cardiorespiratory interactions in infants and children. There are also collaborations with Massey University on research into actigraphy measures of sleep in children at various ages.

Diabetes Research in this area examines the origins of vascular disease in children with diabetes, with the aim of developing new strategies to prevent development or progression of vascular complications of diabetes from an early stage. It also involves risk factors and treatment of hypoglycaemia in diabetes.

Allergy and Asthma UOW Studies recently completed or ongoing include the long term benefits of perinatal and early childhood supplementation with probiotics on the subsequent development of asthma and rhinitis; the role of indoor mould and damp on asthma; the value of exhaled nitric oxide in the management of asthma and the degree to which this is driven by atopy; the importance of endotoxin on atopic sensitisation; gut permeability in early childhood eczema; the mechanisms by which probiotics and prebiotics alter atopic sensitisation; the benefits of different materials on infantile eczema. There are strong research links with the Wellington Asthma Research Group and the Wellington Housing Study group and links are being developed with Xiamen, China.

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Lynette Sadleir Early vascular disease in children with epilepsy Wellington Medical 9,818 receiving anticonvulsants Research Foundation

2007 Dr Lynette Sadleir Genetics of Epilepsy HRC – Project 149,916

2007 Dr Lynette Sadleir Early vascular disease in children with epilepsy Wellington Medical 11,000 receiving anticonvulsants Research Foundation

Total $170,734

Total for all grants active in 2007-8 but awarded prior to 2007 $165,951

Grand total $336,685 * GST exclusive

Research Contracts

Year Approved Organisation

2008 The New Zealand Merino Company Ltd

Total $30,000

Postgraduate Students

Total Head Count* 2007 2008

PhD 1 1 Masters† - -

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 95 DEPARTMENT OF PATHOLOGY AND MOLECULAR MEDICINE

Acting Head of Department: Dr Michael Humble. Email: [email protected]

The Department of Pathology and Molecular Medicine is a multidisciplinary unit in which the subdisciplines of haematology, microbiology, chemical pathology, anatomical pathology and molecular pathology are represented. Current research activities within the Department are focused on the causes and behaviour of various cancers with a specific emphasis on breast, cervix, kidney, prostrate and bladder malignancy. Dental research and urogenital pathology are also areas of research focus.

Website: http://www.wnmeds.ac.nz/academic/pathology/index.html UOW

Major Areas of Research Strength

Dental research The Dental Research Unit has an extensive research programme investigating dental mineralisation, causes of tooth decay and oral microbiology. Studies to date include plaque growth and development, regulation of plaque pH, urea metabolism, plaque mineralisation by calcium phosphates, enamel demineralisation and fluoride effects, antiplaque agents, and the biodiversity and ecology of dental plaque bacterial communities. The Unit houses a novel computer-controlled ‘multiplaque artificial mouth’. This allows the development of realistic plaque microcosm biofilm model systems.

Urogenital pathology Research activities are focused on the classification, diagnosis, molecular biology, growth kinetics and outcome prediction for adult and childhood renal tumours. Other areas of research are: the pathogenesis and spread of bladder cancer; the pathenogenesis, diagnosis and behaviour of testicular tumours and prostate cancer; and progeria kidney.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 A/P David Lamb Markers of biological behaviour (MOBB) Prostate Cancer 152,991 Foundation of NZ Project

2008 Dr Sara Filoche Visualizing pathogens in dental plaque of Maurice and Phyllis 1,500 different individuals Paykel Trust

2007 A/P David Lamb RADAR Prostate Cancer Trial – renewal grant Cancer Society Project 486,492

2007 A/P Christopher Bridging support for 04/259 Dental caries and HRC – Project 313,311 Sissons cariogenic plaques: the sucrose, fluoride and oral environment nexus

2007 Dr Erin Mahoney The prevalence and carious potential of hyper- HRC – Project 121,794 mineralised molars

2007 Dr Lisa Wong Real-time Quantitative PCR System Lottery Health Research 60,000

Total $1,136,088

Total for all grants active in 2007-8 but awarded prior to 2007 $2,046,521

Grand total $3,182,609 * GST exclusive

96 RESEARCH REPORT 2007/2008 Research Contracts

Year Approved Organisation

2008 Dana-Faber Cancer Institute Inc

Total $171,418

Postgraduate Students UOW Total Head Count* 2007 2008

PhD 8 8 Masters† - 2

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Hong Jun Shi TEC Bright Future Top Achiever Doctoral Scholarship (PhD student)

DEPARTMENT OF PRIMARY HEALTH CARE AND GENERAL PRACTICE

Head of Department: Professor Tony Dowell. Email: [email protected]

The Department of Primary Health Care and General Practice undertakes research into aspects of health, illness and disease relevant to general practice and primary care. Research interests include: bioethics; general practice/primary care processes and management; guidelines in primary health care; health promotion; health services research; management of illness; men’s health; undergraduate medical education; and women’s health.

Website: http://www.wnmeds.ac.nz/academic/gp/index.html

Major Areas of Research Strength

Women’s health Many diseases including osteoporosis, depression, breast cancer, menopause and Alzheimer’s disease differentially affect women. The Women’s Health Research Centre (WHRC) works collaboratively, both internationally and locally, to explore important health challenges for New Zealand women. Key areas of research focus include: mid-life health; hormone replacement therapy; menopause; cancer; bladder health; diabetes and heart disease among women; and sexual reproductive health. Other areas of interest include: osteoporosis; contraception; fertility; unplanned pregnancy; maternity; and health of the newborn.

Website: http://www.wnmeds.ac.nz/academic/gp/whrc/index.html

Health communication Health communication research is the domain of the Applied Research on Communication on Health (ARCH) Group. Research focuses on effective doctor-patient communication. The group has been collecting video recordings of interactions between medical practitioners and patients since 2003. A searchable digitised collection of medical consultations and related data for use in interaction analysis is currently under development. This is the first data set of its kind in New Zealand. The recorded consultations are being analysed using qualitative techniques. Researchers have identified patterns in the data, and are looking critically at how these relate to current models of consultation and to effective doctor-patient communication. The data will be used to explore reported disparities in access to health services, particularly differences relating to ethnicity and socio-economic status.

Division of HEALTH SCIENCES 97 Health services research A variety of projects and studies in health services research are underway and include: the Palliative Care Partnership Evaluation; the Cancer Patient Journey Project; evaluation of the secondary care prioritisation system for elective surgery; utilisation of primary health care: analysis of routinely collected data (HURA); clinical practice variation; Direct to Consumer Advertising (DTCA); the Falls Prevention Research Study; and evaluation of the Mobile Community Nursing Service.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $

UOW Approved Investigator Approved*

2008 Prof Anthony Dowell Understanding diabetes management: tracking HRC – Project 1,125,166 communication in primary care

2008 Dr Beverley Lawton Wahine Hauora – Inequalities in uterine cancer: HRC – Project 707,473 exploring the pre-diagnosis gap

2008 Dr Beverley Lawton Parental attitudes to HPV vaccination: a survey HRC Partnership 249,538 of Mäori and non-Mäori Programme

2008 Dr Beverley Lawton Are some severe maternity complications Ministry of Health 61,499 preventable? An outcome audit of admissions to ICU – SAMM Audit

2007 Dr Sally Rose Increasing use of long-acting contraceptive Lottery Health Research 137,630 methods by women post-abortion

2007 Dr Beverley Lawton HPV vaccination: a survey of teachers and parents Lottery Health Research 50,148

Total $2,331,454

Total for all grants ≤ $50,000 awarded in 2007-8 $117,320

Total for all grants active in 2007-8 but awarded prior to 2007 $938,444

Grand total $3,387,218 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 New Zealand Guidelines Group Inc Ministry of Health Manawatu Primary Health Organisation

Total $463,950

Postgraduate Students

Total Head Count* 2007 2008

PhD 3 3 Masters† 7 9

* as at 1 June each year † thesis or dissertation students only and includes MhealSc, MPHC and MtravMed students

98 RESEARCH REPORT 2007/2008 DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Head of Department: Professor Pete Ellis. Email: [email protected]

The Department of Psychological Medicine’s research is configured around several themes relevant to mental health practice in the New Zealand setting, including mental health service delivery and evaluation, the interface between psychological and physical health, social psychiatry, psychiatric epidemiology, suicide, and education in the clinical professions. Current major research projects include: • Treatment of Cognitive Impairment in Early Phase Schizophrenia (the ORCA study) • The New Zealand Mental Health Survey (NZMHS)

• Treatment Outcome Measures for New Zealand General Adult Mental Health Services UOW

Website: http://www.wnmeds.ac.nz/academic/psych/index.html

Major Areas of Research Strength

Mental health survey The New Zealand Mental Health Survey was a face-to-face nationwide survey of 12,992 residents aged 16 years and over which was carried out between October 2003 and December 2004. The survey was designed to produce information on the prevalence and severity of anxiety, mood, substance and eating disorders in New Zealand, and their associated disability and treatment. The initial results of the survey have been published by the Ministry of Health in: Oakley Brown, M.A., Wells, J.E., Scott, K.M. (Eds). 2006. Te Rau Hinengaro: The New Zealand Mental Health Survey and in multiple journal articles. The New Zealand Mental Health Survey is part of the World Mental Health Survey consortium, which conducted similar surveys in 20 plus countries. Staff are currently working with overseas researchers to investigate the cross-national data on topics related to the co-morbidity of mental disorders and physical conditions, on gender differences in mental disorders, and on intimate partner violence.

Schizophrenia Research is conducted into schizophrenia, its impact and its treatment. Recent and ongoing projects include: neuropsychological aspects of Mäori diagnosed as suffering from schizophrenia and related diagnostic issues; neuropsychological aspects of schizophrenia; and Theory of Mind in relation to schizophrenia. A key project has been the Towards Well-being Programme – a programme to monitor young people accessing Child Youth and Family Services who are at risk of suicide. After running this major suicide prevention programme during its initial years and demonstrating its effectiveness, researchers are now analysing data stemming from the programme.

External Grants Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Mr Tai Kake Mental Health and Substance Abuse Disorders HRC Seeding Grant 5,000 amongst Rangatahi Mäori Offenders

2007 Dr Sunny Collings Like minds, like mine: setting up and co-ordination Ministry of Health 55,333 of consortium for publishing journal articles

2007 Dr Sunny Collings Who cares? Family care-givers of people Blue skies Fund 7,119 with schizophrenia in NZ

Total $67,452

Total for all grants active in 2007-8 but awarded prior to 2007 $766,610

Grant total $834,062 * GST exclusive

Division of HEALTH SCIENCES 99 Research Contracts

Year Approved Organisation

2007-2008 Case Consulting, Ministry of Health Department of Child, Youth and Family Services

Total $49,332 UOW Postgraduate Students

Total Head Count* 2007 2008

PhD 7 4 Masters† - -

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2007 Prof Pete Ellis College Medal of Honour, RANZCP

DEPARTMENT OF PUBLIC HEALTH

Head of Department: Professor Philippa Howden-Chapman. Email: [email protected]

For about 15 years the main focus of the Department’s work has been monitoring, understanding and mitigating inequalities in health. The Department also has strengths in the areas of understanding professional interactions linked to resource and clinical decisions and social processes, smoking and the tobacco industry, health promotion and policy, obesity and the food industry, ecology and health, infectious diseases, and population mental health.

During the report period, there were two HRC Programme grants housed in the Department: He Kainga Oranga/The Housing and Health Research Programme (HHRP), and The Health Inequalities Research Programme (HIRP).

The Department is also the base for the New Zealand Centre for Sustainable Cities, an inter-disciplinary research centre dedicated to providing the research base for innovative solutions to the economic, social, environmental and cultural development of our urban centres.

Website: http://www.wnmeds.ac.nz/academic/dph/index.html

Major Areas of Research Strength

Housing and health He Kainga Oranga, the Housing and Health Research Programme (HHRP), seeks to examine and elucidate the links between housing and health. The aim is to identify and then evaluate housing-related interventions to improve individual, family and community health. Major studies include the Housing, Heating and Health Study; the Housing, Crowding and Health Study; the Tokelau Extended Family Housing Study; and the Housing, Insulation and Health Study.

Research on the links between cold, damp housing and poor health outcomes has resulted in the inclusion of new targets in the 2007 New Zealand Energy Efficiency and Conservation Strategy. These targets include warm, dry homes, reduced energy costs, improving indoor air quality and reducing asthma by providing subsidies for the installation of insulation and heating for poorer households.

Website: http://www.wnmeds.ac.nz/academic/dph/research/housing/index.html

100 RESEARCH REPORT 2007/2008 In 2008 the Centre for Sustainable Cities was established by members of this programme with funding from the TEC’s Encouraging and Supporting Innovation fund. This initiative is described in the Research Themes and Centres section at the beginning of this report.

Health inequalities research The Health Inequalities Research Programme (HIRP) is an HRC funded programme established in July 2005 to explore, explain and provide solutions for systematic health inequalities in New Zealand. There are eight projects within the HIRP programme: SoFIE-Health; SoFIE-Primary Care; Unequal Treatment – the role of health services; differential colon cancer survival by ethnicity in New Zealand; Neighbourhoods and Health; the New Zealand Census-Mortality Study; CancerTrends; and Social Indicators.

UOW Health promotion and public policy The Health Promotion and Policy Research Unit (HePPRU) aims to foster excellence in research in health promotion and public health policy. The unit places particular emphasis on nutrition and physical activity, tobacco and equity-focused research. Current research projects include: perceptions of policymakers and stakeholders to key tobacco control policies; influences on smoking uptake and second-hand smoke exposure among young people; best practice in advocating innovative and radical tobacco control policies; barriers, supports, and effective policy options to promoting healthy childhood nutrition in primary schools; the feasibility of front-of-pack nutrition information; and enhancing food security and physical activity for Mäori, Pacific and low income families.

Environmental health The Ecology and Health Research Centre is the focus of environmental health research. This research area is an innovation, especially for health sciences in New Zealand. This reflects a growing awareness internationally of impacts on health and well- being of human-induced environmental, and especially ecological change. Research includes health effects of climate change, flooding, and biosecurity issues relevant to human health.

Health services research and policy The Department aims to address policy-relevant health services problems using public health frameworks that emphasise health gains for population groups and the reduction of health inequalities. The health services research activities of the Department are focused on the following main areas: primary care and mental health; ownership, access and organisational characteristics; and access to secondary care.

Mäori health research The Te Röpü Rangahau Hauora a Eru Pömare was established in 1992. The goals of the Centre are to promote and foster health research by, and for, Mäori and to provide an environment in which Mäori can be trained in a variety of research techniques. Research themes include the health effects of unemployment and knowledge, and attitudes and behaviour of Mäori towards tobacco and its use. Health disparities between Mäori and non-Mäori continue to be the foundation of the Centre’s research.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Prof Antony Blakely Health Inequalities Research Programme HRC Programme 4,310,408 Extension

2008 Prof Philippa Warm Homes for Elder New Zealanders: a HRC – Project 1,090,714 Howden-Chapman community trial of people with COPD (WHEZ)

2008 A/P Michael Baker Research on the Health Impacts of Social Housing New Zealand 293,334 Housing Corporation Project

2008 A/P Michael Baker Pandemic influenza control at the borders of National Institutes 258,270 islands and within households of Health

2008 Ms Bridget Robson MoH Fellowship Ministry of Health 220,001

2008 Dr Catherine Collings Media influences on suicidal behaviour: an Te Pou project 200,123 interview study of young people and an investigation of New Zealand suicide-related internet sites

Division of HEALTH SCIENCES 101 2008 Dr Catherine Collings Ultra-brief intervention for common mental HRC Feasibility Study 148,766 health syndromes in primary care

2008 Dr Louise Signal Delivery of 10 Whanau Ora HIA training Ministry of Health 111,710 workshops

2008 Prof Philippa Healthy Housing Evaluation Baseline Housing New Zealand 93,321 Howden-Chapman Corporation Project

2008 Esther Woodbury Automobile: the impact of public and private HRC Disability Research 85,000

UOW transport on health Placement Programme

2008 Ms Bridget Robson Second Cancer Chartbook Mäori and Non- Ministry of Health 58,307 Mäori Cancer Chartbook (Unequal Impact II)

2007 George Thomson Policymaking to reduce smoking around children HRC – Project 700,445

2007 A/P Richard Edwards Developing strategies to reduce smoking uptake HRC Partnership 596,789 and SHS exposure of NZ children Programme

2007 A/P Richard Edwards Pursuing the endgame for the tobacco industry: Marsden Fund Project 344,649 daring to dream

2007 Dr Louise Signal Enhancing food security and physical activity for Auckland Uniservices Ltd 203,756 Mäori, Pacific and low income whanau/families

2007 Dr Louise Signal Promoting Healthy Childhood Nutrition through National Heart 150,000 Primary Schools: A study of barriers, supports Foundation Project and effective policy options

2007 Diana Sarfati Colon cancer treatment in New Zealand Ministry of Health 100,162

2007 Dr Louise Signal Feasibility of traffic light labels to signpost food Auckland Uniservices Ltd 72,367 choices in supermarkets SIGNS

2007 George Thomson Tobacco retailing impacts and context ASH NZ project 59,999

2007 George Thomson Tobacco retailing impacts and context Cancer Society Project 59,999

Total $9,158,120

Total for all grants ≤ $50,000 awarded in 2007-8 $510,148

Total for all grants active in 2007-8 but awarded prior to 2007 $11,139,945

Grand total $20,808,213 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Tertiary Education Commission Ministry of Health World Health Organisation Accident Compensation Corporation Auckland City Council

Total $3,234,600

102 RESEARCH REPORT 2007/2008 Postgraduate Students

Total Head Count* 2007 2008

PhD 23 26 Masters† 12 12

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships UOW

Year Researcher Award/Scholarship

2008 Prof Philippa Howden-Chapman Companion of the Queen’s Service Order (QSO)

2008 Prof Philippa Howden-Chapman The Liley Medal

2008 Prof Philippa Howden-Chapman Dame Joan Metge Medal

2008 Bridget Robson Officer of the New Zealand Order of Merit (ONZM)

2007 Prof Philippa-Howden-Chapman The Energy Efficiency and Conservation Authority’s EnergySmart Outstanding Contribution to Sustainable Energy Award

From left: Dr Nick Wilson, Dr George Thomson and Associate Professor Richard Edwards of the Health Promotion and Policy Research Unit

Division of HEALTH SCIENCES 103 DEPARTMENT OF RADIATION THERAPY

Head of Department: Ms Karen Coleman. Email: [email protected]

Major Areas of Research Strength

Cancer biology Cancer research is being undertaken in conjunction with the Malaghan Institute of Medical Research in Wellington and the Peter MacCallum Cancer Centre in Melbourne, Australia. A major research interest is the plasma membrane as a target for

UOW cancer drug development. A transport system in the cell membrane that is used very extensively by cancer cells has recently been characterised. Drugs that interfere with this transport system cause cell death by apoptosis in cell cultures and mouse models. Designing drugs that specifically target the plasma membrane and do not enter the cell should be effective in cancer control without the severe side effects experienced by most conventional chemotherapeutic drugs. Drug testing and development is the current focus of research in the group.

Clinical trials Two stage II clinical trials were open for recruitment or in preparation: • Mepilex skin trial which investigates the effects of Mepilex Lite dressings on the extent of radiation-induced skin reactions in 40 women treated for breast cancer. This trial opened for recruitment in Dunedin on May 24, 2008, with 20 women recruited by the end of January 2009. This trial will run until August 31, 2009. • Honey trial which investigates the effects of Manuka Honey on the extent of radiation-induced oral mucositis in 120 patients treated for head and neck cancer. This trial opened on March 1, 2009 in Dunedin, Wellington and Palmerston North and will run until March 2011.

Role extension for radiation therapists Role extension requires radiation therapists to perform duties outside their current scope of practice with the aim of increased job satisfaction and job retention. A survey was carried out in 2008, canvassing the opinion of all radiation oncologists and radiation therapists in New Zealand on the advantages and disadvantages of role extension for radiation therapists. Responses were generally positive and in favour of role extension in some areas, including radiation therapist led treatment review, educating patients about procedures, radiation-induced side effects and general patient care and performing breast mark ups. Pilot studies will be carried out in these areas to establish whether radiation therapists are competent to perform these additional roles. As role extension is only possible with adequate education and training, the Department will be running a Postgraduate Course in Advanced Practice in conjunction with Monash University (Melbourne, Australia) in 2009.

Psycho-oncology Psycho-oncology is the investigation into the psychosocial impact of cancer and its treatments, and is undertaken in areas with particular relevance to the radiation therapy profession. One study is examining the late-effects of pelvic radiation therapy on women’s well-being in their intimate relationships. Another project is investigating the effect that treating cancer patients has on radiation therapy students. An initial pilot study revealed that treating cancer patients affects the identity development of the students and that a significant number of students had experienced a death-related event prior to entering the undergraduate radiation therapy programme. Further studies are planned to investigate whether these findings were specific to this particular cohort of students or are pertinent to radiation therapy students in general.

DEPARTMENT OF SURGERY AND ANAESTHESIA

Head of Department: Associate Professor Duncan Galletly. Email: [email protected]

The Department of Surgery and Anaesthesia is involved in a range of research fields: surgery, anaesthesia, resuscitation, emergency medicine and cardio-respiratory physiology.

Website: http://www.wnmeds.ac.nz/academic/dos/index.html

Major Areas of Research Strength

Cardio-respiratory interactions Research interests lie in exploring cardiovascular and respiratory interactions using a range of time series analysis tools. Current themes include: • Heart rate variability – in particular the physiological significance of heart rate and blood pressure variability, and time series analysis of heart rate variability under different clinical, pharmacological and physiological conditions.

104 RESEARCH REPORT 2007/2008 • Cardioventilatory coupling – the entrainment of respiratory rhythm by cardiovascular afferent inputs, including the mechanisms of entrainment and the physiological consequences of entrainment of inspiratory timing to non-respiratory afferent inputs. • Ventricular fibrillation – time series analysis of this lethal arrhythmia, and the information content of signals derived from implanted cardioverter defibrillators. • Breath to breath respiratory variability – the control of respiratory timing, particularly during sleep in the adult, newborn and infant, the occurrence of central apnoeas, and patterns of breathing during anaesthesia.

External Grants Awarded 2007-2008 UOW Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Shieak Tzeng Differential effect of anaesthetic agents on Wellington Medical 4,950 respiratory sinus arrhythmia in the rat Research Foundation

2008 Mr Peter Sin Autonomic regulation of cardiovascular variability Wellington Medical 4,800 in the anaesthetized rat Research Foundation

2007 Dr Shieak Tzeng Respiratory sinus arrhythmia National Heart 240,000 Foundation Training Fellowship

2007 Dr Peter Larsen Isolated Perfused Heart Apparatus Lottery Health Research 39,080

Total $288,830

Total for all grants ≤ $4,000 awarded in 2007-8 $13,989

Grand total $302,819 * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 5 4 Masters† 1 1

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2007 Shieak Tzeng MacDiarmid Young Scientist of the Year Award, Advancing Human Health category

2007 Shieak Tzeng National Heart Foundation Research Fellowship

Division of HEALTH SCIENCES 105 SCHOOL OF PHARMACY

Dean: Professor Ian Tucker. Email: [email protected]

The School has four focussed research areas which underpin the Quality of Medicines, the Quality and Safe Use of Medicines and Access to Medicines. Three of these focussed areas are: Drug Formulation and Delivery (Quality of Medicines), Clinical Pharmacy (Quality and Safe Use of Medicines), Social Pharmacy (Access to Medicines). In addition, the fourth area of biopharmaceutical sciences underpins both Quality of Medicines and the Quality and Safe Use of Medicines (see below).

Website: http://pharmacy.otago.ac.nz/pages/research.html PHARMACY

Major Areas of Research Strength

Drug formulation and delivery Bioactive materials such as drugs, vaccine antigens, pesticides and nutrients cannot be administered in their pure form, but must be incorporated into biocompatible formulations which maintain their stability and deliver them in a way that achieves optimal beneficial effects while minimising unwanted side effects. This field has important human, veterinary and agricultural applications. Ongoing work includes: chemical and physical stability of drugs in formulations; controlled release devices to deliver bioactives to specific regions of the body; single-shot vaccines for veterinary and human use; delivery of poisons or vaccines to possums for control of Tb; oral delivery of peptide and protein drugs; and micro- and nanoencapsulation technologies. A range of current projects investigates manipulation of solid state properties to improve dissolution, solubility and bioavailability of problem drugs. The development of novel vaccine carrier systems is also an important theme in the group’s work.

Biopharmaceutical sciences Research in this area includes drug discovery, drug metabolism and drug action to extend the range of drugs available and to provide a scientific basis for the quality use of medicines and bioactive substances. Specific areas of research include: computational methods encompassing rational, structure and analogue based drug design techniques, drug target identification and lead optimisation; studies on drug absorption and the role of transporters; preclinical assessment of new chemical entities including small molecular weight and polypeptide bioactives; studies on drugs of abuse aimed at harm minimisation and for application in forensic toxicology; and pharmacokinetic and toxicity studies on synthetic bioactives and those extracted from natural sources. This research is underpinned by the development of analytical methods for drugs in formulations and body fluids;

Clinical pharmacy Clinical pharmacy is the area of pharmacy concerned with patient care and the optimisation of medication use in order to promote health and wellness, and prevent disease. Research in this area includes biopharmaceutical, pharmacokinetic and pharmacodynamic strategies to optimise drug therapy in patients; consideration of adverse or toxic events to minimise harm; the study of drug and food metabolic interactions in special populations; toxicovigilance and optimal use of medicines; and pharmacoeconomics to minimise wastage and optimise use of medicines.

Social pharmacy The underlying theme of social pharmacy research within the School of Pharmacy is to improve access to, and the use of, medicines. Several projects explore medicines use in the community, a number of which involve using large datasets to examine medicines use by gender, age, ethnicity and socio-economic status. Other projects look at the extent of medicines wastage in the community and lay people’s understanding and use of medicines. Staff members have an interest in pharmacy practice in developing countries. A current project investigates the quality of medicines in South Africa, and other staff members have carried out research in Nepal and Samoa. The evaluation of pharmaceutical policy is also an important theme in the group’s work.

106 RESEARCH REPORT 2007/2008 External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Pauline Norris Medications in everyday life: Understandings and Massey University 67,841 social practices

2007 Dr Pauline Norris Equity in prescription medicines use HRC – Project 911,505

Total $979,346 PHARMACY

Total for all grants ≤ $50,000 awarded in 2007-8 $98,257

Total for all grants active in 2007-8 but awarded prior to 2007 $307,751

Grand total $1,385,354 * GST exclusive

Research Contracts

Year Approved Organisation

2007-2008 Bomac Research Ltd, Mastitis Research Centre Ltd LactoPharma Industrial Research Ltd Heidelberg Pharma Roche Products (NZ) Ltd Seperex Limited AgResearch Roche (Switzerland) Phosphagenics Limited Bayer AG Healthcare Germany Comvita New Zealand Ltd Australian Nuclear Science Cawthron Institute Boehringer Ingelheim (Germany)

Total $1,964,302

Postgraduate Students

Total Head Count* 2007 2008

PhD 40 37

Masters† - 1

* as at 1 June each year † thesis or dissertation students only

Division of HEALTH SCIENCES 107 Awards and Scholarships

Year Researcher Award/Scholarship

2008 Prof Ian Tucker Australasian Pharmaceutical Science Association Medal

2008 Dr Rhiaanon Braund Otago University Students Association Teaching Award

2007 Dr Rosemary Beresford Officer of the New Zealand Order of Merit

PHARMACY 2007 Prof Thomas Rades Honorary Professor, School of Life and Health Sciences, Aston University, Birmingham, UK

Professor of Social Pharmacy Pauline Norris

108 RESEARCH REPORT 2007/2008 SCHOOL OF PHYSIOTHERAPY

Dean: Professor David Baxter. Email: [email protected]

Research and knowledge transfer are integral parts of the School’s activities, and these areas continue to develop rapidly. The School’s external research funding has more than trebled in the last three years, and it has active research programmes in a variety of rehabilitation related areas, which are managed through the new New Zealand Centre for Physiotherapy Research. Current research interests are varied and include lower back pain, neurorehabilitation, rehabilitation in multiple sclerosis, physiological and clinical effects of electrophysical agents.

Website: http://physio.otago.ac.nz//res/projects.asp PHYSIOTHERAPY

Major Areas of Research Strength

REAL (Rehabilitative Exercise and Activity for Life Neurological Research Group) Research focuses on physiotherapy interventions and rehabilitation in the elderly and in populations with neurological dysfunction. The aim is to enhance participation in daily life for these populations. A key area is falls intervention programmes for older adults. Falls are the most common form of injury among the elderly and the consequences can be devastating for the individual as well as costly to health providers. The ACC funds Tai Chi classes for more than 6,500 elderly people each year and researchers are evaluating the programme’s benefit in reducing the risk of falls in this group. Research is also being carried out into preventing falls in adults with intellectual disability, an area that has traditionally received little physiotherapy input. The benefits of exercise interventions for those with multiple sclerosis and Parkinson’s disease are also being explored.

AMOCK (Advancement of Musculoskeletal, Occupational Health and Clinical Knowledge Research Group This theme involves a diverse range of research projects in the areas of rural ergonomics, biomechanical studies, activity monitoring, low level laser therapy, and osteoarthritis intervention and treatment. Examples of current major studies in this area follow.

Two major projects are underway in the area of rural ergonomics. This is an important research area in New Zealand where large numbers of workers are employed in the rural sector. The first relates to spinal injuries in farmers caused by exposure to vibrations from extended use of quad bikes. The second project is examining the forces exerted on the spines of shearers, as well as the beneficial effects of using back harnesses. A study examining the effectiveness of a number of physiotherapy approaches for hip and knee osteoarthritis is also underway. It is hoped that such interventions could delay or even prevent the need for joint replacements, a finding that could have huge economic benefits for New Zealand.

SPEX (Sport and Exercise) Research Group Research focuses on injury mechanisms, injury screening and prevention, and rehabilitation strategies for sport and exercise injuries. An additional area of interest is the use of exercise to promote health and a healthy lifestyle across the entire lifespan. Currently, researchers are developing a pre-hospital sideline assessment tool for use by sports physiotherapists to screen for concussion. Also ongoing is a study into whether musculoskeletal screening can predict injury in elite athletes. Investigators are also exploring the interaction between the pelvic segment and gluteal and thigh muscles. Findings may contribute towards the more effective prevention of common hamstring and groin injuries.

External Grants > $50,000 Awarded 2007-2008

Year Principal Project Title Funder Total $ Approved Investigator Approved*

2008 Dr Leigh Hale Aqua Aerobics to improve falls risk in adults with Lottery Health 70,414 osteoarthritis

2008 School of The New Zealand Centre for Physiotherapy HRC Disability 56,667 Physiotherapy Research Research Placement Programme

2007 Dr Haxby Abbott Decreasing pain, disability, waiting lists and costs HRC – Project 471,764 of osteoarthritis

2007 Prof John Sullivan Clinical Research System for Balance Assessment Lottery Health Research 155,000 and Treatment

2007 Dr Haxby Abbott Economic analysis of physiotherapy care to HRC Feasibility Study 109,565 reduce costs of osteoarthritis

Division of HEALTH SCIENCES 109 2007 Dr Haxby Abbott Reducing the disability, pain, costs and waiting lists Lottery Health Research 50,001 of osteoarthritis

Total $913,411

Total for all grants ≤ $50,000 awarded in 2007-8 $93,216

Total for all grants active in 2007-8 but awarded prior to 2007 $712,624

Grand total $1,719,251 PHYSIOTHERAPY * GST exclusive

Postgraduate Students

Total Head Count* 2007 2008

PhD 16 20 Masters† 7 6

* as at 1 June each year † thesis or dissertation students only

Awards and Scholarships

Year Researcher Award/Scholarship

2008 Dr Leigh Hale Fellow of the New Zealand College of Physiotherapy

2008 Dr Margot Skinner Fellow of the New Zealand College of Physiotherapy

2008 Dr Gill Johnson Fellow of the New Zealand College of Physiotherapy

Dr Haxby Abbott who is investigating the cost-effectiveness of physiotherapy for those with osteoarthritis

110 RESEARCH REPORT 2007/2008 COMMERCIALISATION

Making a difference to the health and well-being of people both in New Zealand and internationally is a key focus for the Division. Where opportunities arise to do this through the commercialisation of research results, this is strongly encouraged and supported. The University has a generous intellectual property (IP) policy that encourages innovation.

This section provides information about commercialisation activities, our patent portfolio, intellectual property (IP) policy and other related matters.

Commercialisation Activities

• Contract Research • Patents • Licensing and spin-out companies

Contract Research A large part of the Division’s commercial activities involve contract research. The greatest proportion of this is carried out for New Zealand government departments, including the Ministry of Health. For example, the Division houses and runs two major national facilities for the Ministry of Health: the National Poisons Centre and the New Zealand Pharmacovigilance Centre. The former runs a 24-hour hotline providing advice on poisoning to the public, General Practitioners, hospitals and industry. The New Zealand Pharmacovigilance Centre is New Zealand’s national monitoring centre for adverse reactions.

New Zealand’s Accident Compensation Corporation (ACC) has commissioned a significant number of studies and reports, largely from the long-established Injury Prevention Unit in the DSM. These studies have ranged from traffic accidents, to childhood injury, to swimming deaths, to alcohol-related injury and death.

Other substantial contracts are held with New Zealand’s Crown Research Institutes to conduct research for their own research programmes funded by the Foundation for Research Science and Technology (FRST). Staff in the Division have also carried out substantial research for Fonterra, New Zealand’s global dairy company, and for their research arm Lactopharma. Additionally, commercial contracts exist with other New Zealand companies.

Disclosures and Patents During 2007-8 an average of 34 ideas with potential commercial outcomes were disclosed annually to the Research and Enterprise Office. Nine patents were filed in 2007 and 12 in the first half of 2008. Twelve patents (provisional) were awarded during the 2007-2008 period.

Licensing and Spin-out companies During the period from 2004 to the end of 2008, 10 licences or similar were signed. Staff in the Division entered into 4 agreements for collaborative development of technology, which may lead to a licence or sale in the future. In addition 5 of Otago’s spin-out companies are based on Divisional technology, although not all were formed during the period 2007-2008. Examples include:

Antipodean Pharmaceuticals Inc: A San Francisco based biotech company, which has just completed three Phase II trials using a compound developed in a collaboration between Professor Rob Smith from Chemistry and Professor Mike Murphy, previously from Biochemistry. The results of the trials will be known shortly.

Pacific Edge Biotechnology Ltd: This is a publicly listed company which is developing novel diagnostic and prognostic tests for a number of cancers. Clinical trials for a set of bladder cancer markers are about to commence. The technology is based on work undertaken by Professor Tony Reeve and the Cancer Genetics Laboratory in the Department of Biochemistry.

A licence was signed with Biosite Inc from San Diego for a biomarker linked to bone growth. The technology is based on the work of Professor Eric Espiner, Professor Tim Yandle and Dr Tim Prickett from UOC.

A licence was signed with Keratec Ltd for an orthopaedic screw developed from Keratin. The screw was developed and tested by Dr George Dias and Dr Phil Peplow from the Department of Anatomy and Structural Biology.

A licence was signed with the New Zealand company Merinova for Hoki Liver Oil extract, which was identified as being bio- active by Dr Paul Davis of the Bio-active Investigation Group in UOW.

Division of HEALTH SCIENCES 111 COLLABORATIONS WITH EXTERNAL ORGANISATIONS

The Division has many diverse collaborations and affiliations with organisations external to the University of Otago. A selection is provided below.

Centre for Reproduction and Genomics: http://www.crg.org.nz/ In 2007, the University of Otago signed an MoU with AgResearch, the largest of New Zealand’s Crown Research Institutes, in order to establish a Centre for Reproduction and Genomics in Dunedin. This MoU governs the recent appointment of a joint Chair and a joint fund for collaborative research. See the section on Research Centres for further information.

New Zealand Centre for Sustainable Cities: http://sustainablecities.org.nz/ This Centre is led by the University of Otago and is a partnership of six universities (Otago, Canterbury, Victoria, Massey, Waikato and Auckland) and three Crown Research Institutes (Landcare, NIWA and BRANZ). See the section on Research Centres for further information.

New Zealand Genomics Consortium: This Divisional led consortium will involve formal agreements with seven of New Zealand’s eight Universities and seven of its nine Crown Research Institutes. The Consortium will provide a collaborative national infrastructure for the provision of advanced genomics technologies in New Zealand.

National Centre for Lifecourse Research: http://www.lifecourse.ac.nz/home/ This Centre joins the two world leading longitudinal studies in Dunedin and Christchurch. It is also extensively connected externally with their partners including the Pacific Islands Families Study at Auckland University of Technology, the Roy McKenzie Centre for the Study of Families at Victoria University Wellington, and the Population Studies Centre at Waikato University. Relationships with Auckland University and Environmental Science and Research (ESR, a Crown Research Institute) are also being finalised. See the section on Research Centres for further information.

Partnering for Innovation: In 2008, a new Divisional initiative funded by the TEC’s Encouraging and Supporting Innovation Fund, was launched to help facilitate development and translation of research to support and grow new science based industries. This proposal was developed in conjunction with the Universities of Canterbury and Lincoln and will result in significant collaboration towards these goals.

Other significant relationships exist with:

• Faculty of Medical and Health Sciences, University of Auckland • Ngäi Tahu • Other Iwi • District Health Boards, especially Otago, Canterbury, Capital Coast, Hutt Valley and Southland.

• Government Departments: ~ Ministry of Health ~ Ministry for Social Development ~ Ministry for Research, Science and Technology ~ Department of Corrections ~ ACC ~ New Zealand Trade and Enterprise

• Crown Research Institutes where the Division holds a FRST subcontract: ~ AgResearch ~ Cawthorn Institute ~ Plant and Food New Zealand (formerly Crop & Food and HortResearch) ~ IRL, Industrial Research Limited ~ NIWA, National Institute of Water and Atmospheric Research ~ ESR, Environmental Science and Research

112 RESEARCH REPORT 2007/2008 Centres of Research Excellence: Divisional staff are listed as Principal or Associate Investigators in the following national Centres of Research Excellence:

National Centre for Growth and Development (Auckland University) Professor Tony Reeve, OSMS (until 2007) Professor Ian Morison, DSM Professor Christine Winterbourn, UOC

Maurice Wilkins Centre for Molecular Biodiscovery (Auckland University) Dr Peter Dearden, OSMS

The MacDiarmid Institute for Advanced Materials and Nanotechnology (Canterbury and Victoria Universities) Associate Professor John Evans, UOC

International connectivity It is impossible to track accurately all collaborations with organisations and countries as most members of staff have numerous national and international connections. The USA, EU, South-East Asia, Japan and Australia account for the majority of Divisional collaborations.

Investment in International Opportunities Fund The Division has received a number of awards from this fund to build on excellent collaborative research with overseas partners. Details are provided in the table below.

Awards from Investment in International Opportunities Fund

Researcher Project Country

Dr David I McBride, DSM An international cross cultural survey of musculoskeletal UK+26 others disorders and causes of disability

Associate Professor Russell Poulter, OSMS Microbial models of the human L1 retrotransposon USA

Professor David Grattan, OSMS Brain actions of prolactin in the postpartum period USA

Associate Professor Tony Merriman, OSMS Whole genome association scanning for common USA autoimmunity genes

Professor Richard Cannon, Dentistry Human membrane protein expression system. A novel Japan protein expression system for human membrane protein analysis and drug discovery

The Division hosted five international researchers and academics on William Evans Fellowships during 2007-8, including: Professor Amanda Howe, Faculty of Medicine and Dept of General Practice, DSM; Professor K. Hawton, Psychological Medicine, UOC; Professor John Eccleston, School of Pharmacy; Professor Karin Olson and Associate Professor Stephen Marshall, School of Physiotherapy; and Associate Professor David Eager, Preventive and Social Medicine, DSM.

Division of HEALTH SCIENCES 113 RESEARCH SUPPORT SERVICES

The Health Sciences Division hosts the following research support services:

Anatomy Museum and Human Skeletal Collection The W.D. Trotter Anatomy Museum in the Department of Anatomy and Structural Biology was established in 1874 and holds a large collection of anatomical specimens and models, many of which date back to the late 1800s. The Museum also holds many osteological specimens and an extensive collection of normal and abnormal radiographs.

The Department has a well-equipped plastination laboratory which provides many of the new material for the Museum’s collections. A number of plastination techniques are undertaken including the silicone technique for plastinated prosections, E12 for transparent body slices, and P35 for thin brain slices.

The Department’s anthropological collection of human skeletal material is the largest in New Zealand. Postgraduate students and staff from any department in the University may apply for research-based access to the Museum and skeletal collections. http://anatomy.otago.ac.nz

Anatomy Otago Genomics Sequencer The Department of Anatomy and Structural Biology houses state-of-the-art Roche/454 GS FLX and ABI SOLiD systems gene sequencers. These sequencers are widely regarded internationally as a breakthrough technology that will transform research in the biological sciences. A sequencing service is provided and enables sequencing of template from any source, to any specification, including: • Eukaryotic genomes • Bacterial genomes • Viruses • Cloned DNA such as BACs and plasmids • Transcriptomes including small RNAs • Amplicons http://sequence.otago.ac.nz

Biomechanics Laboratory The 12-camera Motion Analysis System (Motion Analysis Corporation) in the Biomechanics Laboratory of the School of Physiotherapy provides clinicians, researchers, coaches and industry with an accurate description of how a person moves during sporting, workplace or everyday activities.

Two Advanced Mechanical Technology Inc. Force Plates provide information on external ground reaction forces while electromyography provides information in the temporal sequencing of muscle activity in the generation of movement. The Biomechanics Laboratory also provides motion capture (MoCap) to the animation industry in applications such as computer games, advertising and television programs.

The TeleMyo 2400T-G2 12 channel telemetric SEMG system (Noraxon), gives insight into muscle recruitment and muscle temporal activity in the generation of movement. http://physio.otago.ac.nz/gait/about/about.asp

Biostatistical and Bioinformatics Services The Division and Schools provide professional Biostatistical Services that are available across the three campuses. Individual arrangements for accessing the services exist in each School.

Bioinformatics expertise and advice is available through the Department of Biochemistry, especially those problems pertaining to microarray data (contact: Dr Mik Black.)

114 RESEARCH REPORT 2007/2008 Centre for Protein Research The Centre for Protein Research (CPR) is a joint facility of the Departments of Biochemistry and Microbiology and Immunology. It is equipped with state-of-the-art as well as robust standard technologies for protein and proteome analyses. The CPR follows the concept of a user laboratory and supports research projects of the departments of Biochemistry and Microbiology and Immunology. The Centre also provides service analyses for other departments within the University of Otago and for external institutes. Services available include sample preparation, peptide mass spectrometry, protein mass spectrometry and data analysis. http://biochem.otago.ac.nz/cpr/home.html

Histology Unit The Division houses the Pathology Anatomy Histology Unit (PAHU). The Unit provides histology services for University researchers as well as outside companies. It also offers diagnostic dental services for the country. The Unit undertakes processing, cutting and staining of all types of tissue. Routine staining, immunoperoxidase and fluorescent techniques are all catered for. Qualified Medical Laboratory Scientists are available to advise on all aspects of histology and to instruct users in either staining techniques or use of equipment. Equipment available for use includes: a cryostat, an embedding machine, a microtome, staining machines and a light microscope.

Contact: Mandy Fisher, Department of Pathology [email protected] Lynda Horne, School of Dentistry [email protected]

Otago Centres for Electron and Confocal Microscopy The Otago Centre for Electron Microscopy (OCEM) is well-equipped for all conventional electron microscopy applications. The Centre specialises in a range of cryopreparation techniques (both transmission electron microscopy and scanning electron microscopy) and immunocytochemical techniques.

There are two transmission electron microscopes, a Phillips CM 100TM and a Phillips 410LS TEM. The scanning electron microscopes are a JEOL 6700f field emission scanning electron microscope and a Cambridge S360 conventional SEM. The JEOL 6700f is fitted with an Alto 2500 high resolution cryostage for working with frozen hydrated specimens, and an elemental analysis (EDS) system.

The Otago Centre for Confocal Microscopy (OCCM) works in close association with the OCEM. It has two Zeiss LSM 510 confocal laser scanning microscopes: one configured for fixed, slide mounted material, the other for live cell investigations. Both are also capable of phase contrast, DIC, brightfield and fluorescence microscopy. There is also an Olympus FV1000 confocal laser scanning microscope which is configured to extend the range of experimental procedures, particularly those in the shorter excitation range. The Centre also has a UMIS, nano-indenter system which augments hard tissue morphology data by quantifying its physical attributes, and a SkyScan 7200 high resolution micro CT scanner. http://anatomy.otago.ac.nz/

Otago Flow Cytometry Facility The Flow Cytometry (FACS) Facility provides the University of Otago with fluorescent cell analysis and sorting, magnetic bead separation and fluorescent protein detection technology. The facility is situated in two locations on the campus. Two analysers and the fluorescent and magnetic bead based cell sorters, are housed within the Department of Microbiology and Immunology. The other analyser is housed within the Wellcome Institute. In addition the facility offers a Bioplex machine that allows researchers to simultaneously analyse multiple analytes, such as cytokines, within biological samples. These can be used for the analysis of complex cell suspensions: (blood cells, bacterial communities, disaggregated tumours, cell cycle analysis).

Contact Dr Alex McLellan: [email protected]

Division of HEALTH SCIENCES 115 Otago Genomics Facility The Otago Genomics Facility (OGF) was established in July 2000 to provide University of Otago researchers with access to microarray technology. The Facility provides researchers with the ability to analyse patterns of gene expression in normal growth and development, and in disease states.

The facility comprises two powerful technologies: gene expression microarrays and laser capture microdissection (LCM). The OGF microarray lab provides DNA microarray technology allowing researchers to determine gene expression levels using cDNAs and oligos arrayed on glass slides. The use of microarrays on glass slides provides a relatively simple means of obtaining large-scale expression data for thousands of individual genes from a single experiment. Microarray technology is revolutionising research into gene discovery, disease diagnosis and treatment, and drug development for diseases such as cancer. http://genomics.otago.ac.nz/

Protein Crystallography Facility Professor Krause serves as the Director of a newly installed protein crystallography facility at the University of Otago. The facility consists of three large temperature controlled rooms. One is devoted to crystallisation and contains a new MosquitoTM crystallisation robot. The second room contains computer control and modelling facilities. The third room contains a MicroMax007HF with an R-axis IV++ area detector. It is equipped with both chromium and copper anodes and separate optics. Chromium radiation is used for single wavelength anomalous diffraction (SAD) determination of protein structures, mitigating in most cases the need to visit a synchrotron. This approach has been effective for proteins with 2% or more S or Se containing residues. The flux of this machine is roughly equivalent to the protein crystallography beamline at the LSU- CAMD synchrotron facility in Baton Rouge, La. Cryo-cooling is carried out using a Rigaku X-stream 2000 cooling system. The University is also part of a consortium that will have regular access to the protein beamlines at the Australia National Synchrotron in Melbourne. Beamlines there will be optimised for MAD structure determination and native data collection.

Researchers interested in pursuing a protein crystal structure determination should email Professor Krause at: kurt.krause@ stonebow.otago.ac.nz

Real Time PCR An ABI PRISM 7000 real-time PCR machine is available in the Department of Pathology, and offers:

• Multi-colour detection for multiplex quantitation assays, allelic discrimination assays, and plus/minus assays, tungsten- halogen illumination and compatibility with the following dyes: FAM/SYBR Green 1, VIC/JOE, NED/TAMRA, and ROX • PC-based software, including the latest version of the Sequence Detection System Software for the ABI PRISM 7000 • Automated primer and probe design using Primer Express Software • Complete compatibility with the ABI PRISM 7700 Sequence Detection System assay design and PCR characteristics.

Contact Professor Mike Eccles at: [email protected]

University of Otago, Christchurch A full range of molecular and cell biology equipment and tools are available at the Christchurch Campus. The School has an ABI 3130 Genetic Analyser, and a Triple Quadropole Mass Spectrometer with Liquid Chromatography has been approved and will be available shortly. In addition, through the success of a collaborative bid to the TEC from the University of Canterbury and OUC, OUC staff can access new equipment to be housed at the University of Canterbury.

University of Otago, Wellington Artificial Mouth The Dental Research Unit at OUW houses a novel computer-controlled ‘multiplaque artificial mouth’. This allows the development of realistic plaque microcosm biofilm model systems.

Contact Associate Professor Chris Sissons at: [email protected]

116 RESEARCH REPORT 2007/2008 DIVISIONAL SUPPORT FOR RESEARCH

Health Sciences has a Divisional Research Committee, consisting of the Associate Deans of Research from each School plus other representatives. (See http://healthsci.otago.ac.nz/research/index.html for Terms of Reference). This Committee meets four or more times annually and controls an annual budget which provides:

• Postdoctoral Fellowships • PhD conference travel funding • PhD Scholarships for students in professional courses • An annual Divisional Research Forum • Mentoring for targeted grant applications • Review of HRC, TAD and NZS&T applications • Review of PBRF Evidence Portfolio preparation • Research workshops • Other support as decided

This Committee is Chaired by the Division’s Associate Dean for Research, Professor Warren Tate. The Division employs Dr Michele Coleman as its Research and Development Manager and Dr Kerry Galvin to support research.

Email: [email protected]

Division of HEALTH SCIENCES 117 RESEARCH OFFICE

The Otago Research and Enterprise Office deals with research funding and assists researchers in gaining funding from the application/proposal stage right through to contracting and reporting stages. Research and Enterprise staff provide the liaison between the funding bodies, industry or businesses and staff at the University. The Research and Enterprise Office deal with a range of activities including:

• Research grants, proposals and contracts (externally funded travel and equipment grants) • Fellowships • University of Otago Research Grants • Technology transfer • Intellectual property protection (including patents and trademarks) • Material transfer agreements

Under the auspices of the Research and Enterprise Office, research in the Health Sciences Division is supported by a number of Research Advisors and Administrators, and additional staff at the University of Otago, Christchurch and Wellington.

Staff with Health Sciences Responsibilities:

Christine Groves, Research Advisor University of Otago, Wellington [email protected]

Karen Chaney, Research Advisor University of Otago, Christchurch [email protected]

Virginia Irvine, Research Manager University of Otago, Christchurch [email protected]

Ali Cameron, Clinical Research Advisor (DSM) Dunedin School of Medicine [email protected]

Ruth Sharpe, Clinical Research Administrator Dunedin School of Medicine [email protected]

Dr Natalie Harfoot, Research Advisor (Health Sciences) Research and Enterprise Office, Dunedin [email protected]

Dr Eric Lord, Research Advisor (Health Sciences) Research and Enterprise Office, Dunedin [email protected]

Dr Fernanda da Silva-Tatley, Business Manager [email protected]

David Grimmett, Business Manager [email protected]

118 RESEARCH REPORT 2007/2008 APPENDIX 1: PUBLICATIONS BY DEPARTMENT FOR 2007

FACULTY OF DENTISTRY DEPARTMENT OF ORAL DIAGNOSTIC AND SURGICAL SCIENCES

Journal – Research Article Ford, P. J., Gemmell, E., Timms, P., Chan, A., Preston, F. M., & Seymour, G. J. (2007). Anti-P. gingivalis response correlates with atherosclerosis. Journal of Dental Research, 86(1), 35-40. Gemmell, E., Yamazaki, K., & Seymour, G. J. (2007). The role of T cells in periodontal disease: Homeostasis and autoimmunity. Periodontology 2000, 43(1), 14-40. Hall, J. A. G., Payne, A. G. T., Purton, D. G., Torr, B., Duncan, W. J., & De Silva, R. K. (2007). Immediately restored, single- tapered implants in the anterior maxilla: Prosthodontic and aesthetic outcomes after 1 year. Clinical Implant Dentistry and Related Research, 9(1), 34-45. Hamlet, S. M., Taiyeb-Ali, T. B., Cullinan, M. P., Westerman, B., Palmer, J. E., & Seymour, G. J. (2007). Tannerella forsythensis prtH genotype and association with periodontal status. Journal of Periodontology, 78(2), 344-350. Hauman, C. H. J., & Kuzmanovic, D. V. (2007). An evaluation of polymer rotary instruments’ ability to remove healthy, non- carious dentine. European Journal of Prosthodontics and Restorative Dentistry, 15(2), 77-80. Johnson, G. M., Coe, H., Wirawan, R., Wong, L., Lee, C., & MacFadyen, E. (2007). Objective discrimination between mandibular open/close excursion patterns: A clinical case report. The Journal of Craniomandibular Practice, 25(3), 218-224. Kirk, D. G., Liston, P. N., Tong, D. C., & Love, R. M. (2007). Influence of two different flap designs on incidence of pain, swelling, trismus, and alveolar osteitis in the week following third molar surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics, 104, e1-e6. Love, R. M. (2007). Hemin nutritional stress inhibits bacterial invasion of radicular dentine by two endodontic anaerobes. International Endodontic Journal, 40, 94-99. Orozco, A., Gemmell, E., Bickel, M., & Seymour, G. J. (2007). Interleukin 18 and periodontal disease. Journal of Dental Research, 86(7), 586-593. Ponnambalam, Y., Love, R. M., & Thomson, W. M. (2007). Bacterial chemoprophylaxis knowledge and practice among New Zealand dentists. New Zealand Dental Journal, 103(3), 51-57. Rautemaa, R., Lauhio, A., Cullinan, M. P., & Seymour, G. J. (2007). Oral infections and systemic disease: An emerging problem in medicine. Clinical Microbiology and Infection, 13(11), 1041-1047. Seymour, G. J. (2007). Good oral health is essential for good general health: The oral-systemic connection. Clinical Microbiology and Infection, 13(Suppl. 4), 1-2. Seymour, G. J., Ford, P. J., Cullinan, M. P., Leishman, S., & Yamazaki, K. (2007). Relationship between periodontal infections and systemic disease. Clinical Microbiology and Infection, 13(Suppl. 4), 3-10. Zacharias, M., De Silva, R. K., Hickling, J., Medlicott, N. J., & Reith, D. M. (2007). Comparative safety and efficacy of two high dose regimens of oral paracetamol in healthy adults undergoing third molar surgery under local anaesthesia. Anaesthesia and Intensive Care, 35(4), 544-549.

Journal – Professional & Other Non-Research Articles Ong, J. C. J., De Silva, R. K., & Tong, D. C. (2007). Retrieval of a root fragment from the maxillary sinus: An appreciation of the Caldwell-Luc procedure. New Zealand Dental Journal, 103(1), 14-16. Seymour, G. J. (2007). You cannot have good general health without good oral health [Editorial]. New Zealand Dental Journal, 103(2), 26-27. Storr, E. F., de Vere Beavis, F. O., & Stringer, M. D. (2007). Texting tenosynovitis [Case notes]. The New Zealand Medical Journal, 120(1267). Tong, D. C., Leaper, M. R., Colquhoun, A. N., & Rich, A. M. (2007). An unusual presentation of oropharyngeal mucosal plasmacytosis related to toothpaste. The Journal of Laryngology & Otology, 122, 1112-1114.

FACULTY OF DENTISTRY DEPARTMENT OF ORAL REHABILITATION

Journal – Research Article Al-Zubeidi, M. I., & Payne, A. G. T. (2007). Mandibular overdentures: A review of treatment philosophy and prosthodontic maintenance. New Zealand Dental Journal, 103(4), 88-97. Chandler, N., Leichter, J., Oginni, A., & Jennings, M. (2007). Dens invaginatus: A rare case in a maxillary third molar. ENDO, 1(4), 279-282. Goga, R., & Purton, D. G. (2007). The use of endodontically treated teeth as abutments for crowns, fixed partial dentures, or removable partial dentures: A literature review. Quintessence International, 38, 41-46. Hall, J. A. G., Payne, A. G. T., Purton, D. G., Torr, B., Duncan, W. J., & De Silva, R. K. (2007). Immediately restored, single- tapered implants in the anterior maxilla: Prosthodontic and aesthetic outcomes after 1 year. Clinical Implant Dentistry and Related Research, 9(1), 34-45.

Division of HEALTH SCIENCES 119 Hauman, C. H. J., & Kuzmanovic, D. V. (2007). An evaluation of polymer rotary instruments’ ability to remove healthy, non- carious dentine. European Journal of Prosthodontics and Restorative Dentistry, 15(2), 77-80. He, L-H., Carter, E. A., & Swain, M. V. (2007). Characterization of nanoindentation-induced residual stresses in human enamel by Raman microspectroscopy. Analytical and Bioanalytical Chemistry, 389, 1185-1192. He, L. H., & Swain, M. V. (2007). Enamel: A “metallic-like” deformable biocomposite. Journal of Dentistry, 35, 431-437. He, L. H., & Swain, M. V. (2007). Energy absorption characterization of human enamel using nanoindentation. Journal of Biomedical Materials Research Part A, 81A, 484-492. He, L. H., & Swain, M. V. (2007). Influence of environment on the mechanical behaviour of mature human enamel. Biomaterials, 28, 4512-4520. He, L. H., & Swain, M. V. (2007). Nanoindentation derived stress-strain properties of dental materials. Dental Materials, 23, 814-821. Huang, T. T. Y., Jones, A. S., He, L. H., Darendeliler, M. A., & Swain, M. V. (2007). Characterisation of enamel white spot lesions using X-ray micro-tomography. Journal of Dentistry, 35, 737-743. Ichim, I., Kieser, J. A., & Swain, M. V. (2007). Functional significance of strain distribution in the human mandible under masticatory load: Numerical predictions. Archives of Oral Biology, 52, 465-473. Ichim, I., Li, Q., Li, W., Swain, M. V., & Kieser, J. (2007). Modelling of fracture behaviour in biomaterials. Biomaterials, 28, 1317-1326. Ichim, I., Li, Q., Loughran, J., Swain, M. V., & Kieser, J. (2007). Restoration of non-carious cervical lesions: Part I. Modelling of restorative fracture. Dental Materials, 23, 1553-1561. Ichim, I. P., Schmidlin, P. R., Li, Q., Kieser, J. A., & Swain, M. V. (2007). Restoration of non-carious cervical lesions: Part II. Restorative material selection to minimise fracture. Dental Materials, 23, 1562-1569. Ichim, I., Schmidlin, P. R., Kieser, J. A., & Swain, M. V. (2007). Mechanical evaluation of cervical glass-ionomer restorations: 3D finite element study. Journal of Dentistry, 35, 28-35. Kieser, J. A., Bernal, V., Waddell, J. N., & Raju, S. (2007). The uniqueness of the human anterior dentition: A geometric morphometric analysis. Journal of Forensic Sciences, 52(3), 671-677. Lin, J., Chandler, N., Purton, D., & Monteith, B. (2007). Appropriate electrode placement site for electric pulp testing first molar teeth. Journal of Endodontics, 33(11), 1296-1298. Roy, R., & Chandler, N. P. (2007). Contemporary perspectives on root-end management during periapical surgery. ENDO, 1(2), 91-99. Roy, R., & Chandler, N. P. (2007). Tooth discolouration following dental trauma. ENDO, 1(3), 181-187. Tholey, M. J., Waddell, J. N., & Swain, M. V. (2007). Influence of the bonder on the adhesion of porcelain to machined titanium as determined by the strain energy release rate. Dental Materials, 23, 822-828. Waddell, J. N., Ichim, I., Lee, H., Fangtao, L., Payne, A. G. T., & Swain, M. V. (2007). Fatigue failures of bar-attachment brazed joints for implant-supported overdentures. Engineering Fracture Mechanics, 74, 1148-1159. Xie, Z-H., Mahoney, E. K., Kilpatrick, N. M., Swain, M. V., & Hoffman, M. (2007). On the structure-property relationship of sound and hypomineralized enamel. Acta Biomaterialia, 3, 865-872.

Journal – Research Other Desai, S. V. (2007). Natural rubber latex allergy and dental practice. New Zealand Dental Journal, 103(4), 101-107. Minguez, C., & Lyons, K. (2007). Failure of crowns and bridges: A review of the literature. New Zealand Dental Journal, 103(1), 7-13. Schmidlin, P. R., Zehnder, M., Imfeld, T., & Swain, M. V. (2007). Comparative assessment of hardening of demineralized dentin under lining materials using an ultramicroindentation system. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 83B, 199-205. Wong, B. K. J., Leichter, J. W., Chandler, N. P., Cullinan, M. P., & Holborow, D. W. (2007). Radiographic study of ethnic variation in alveolar bone height among New Zealand dental students. Journal of Periodontology, 78(6), 1070-1074.

Working Paper; Discussion Paper; Technical Report Lyons, K. (2007). Partial dentures and crowns. District Health Board New Zealand Oral Health Group. (pp. 1-24).

FACULTY OF DENTISTRY DEPARTMENT OF ORAL SCIENCES

Journal – Research Article Ayers, K. M. S., Meldrum, A., Thomson, W. M., & Newton, J. T. (2007). The working practices and career satisfaction of dental therapists in New Zealand. Community Dental Health, 24, 257-263. Bowley, J. F., & Kieser, J. (2007). Axial-wall inclination angle and vertical height interactions in molar full crown preparations. Journal of Dentistry, 35, 117-123. Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Tanabe, K., & Monk, B. C. (2007). Candida albicans drug resistance: Another way to cope with stress. Microbiology, 153, 3211-3217.

120 RESEARCH REPORT 2007/2008 Chandler, N., Leichter, J., Oginni, A., & Jennings, M. (2007). Dens invaginatus: A rare case in a maxillary third molar. ENDO, 1(4), 279-282. Dennison, J., Healey, D., & Herbison, P. (2007). The Polynesian chin and mandible. Anthropologischer Anzeiger, 65, 241-252. Filoche, S. K., Soma, K. J., & Sissons, C. H. (2007). Caries-related plaque microcosm biofilms development in microplates. Oral Microbiology and Immunology, 22(2), 73-79. Ford PJ, Gemmell E, Timms P, Chan A, Preston FM, Seymour GJ. Anti-P.gingivalis Response Correlates with Atherosclerosis. Journal of Dental Research 2007:86;35-40. Ford, P. J., Yamazaki, K., & Seymour, G. J. (2007). Cardiovascular and oral disease interactions: What is the evidence? Primary Dental Care, 14(2), 59-66. Hall, J. A. G., Payne, A. G. T., Purton, D. G., Torr, B., Duncan, W. J., & De Silva, R. K. (2007). Immediately restored, single- tapered implants in the anterior maxilla: Prosthodontic and aesthetic outcomes after 1 year. Clinical Implant Dentistry and Related Research, 9(1), 34-45. Hamlet SM, Taiyeb-Ali TB, Cullinan MP, Westerman B, Palmer JE, Seymour GJ. Tannerella forsythensis prtH genotype and association with periodontal status. J Periodontol; 2007:78(2):344-350. Healey, D. (2007). Fatal dog bites in New Zealand. The New Zealand Medical Journal, 120(1259). http://www.nzma.org.nz/ journal/120-1259/2659/ Healey, D. (2007). Fatal dog bites in New Zealand. NZMJ Digest, (4), 13-17. Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2007). Competence-dependent bacteriocin production by Streptococcus gordonii DL1 (Challis). Journal of Bacteriology, 189(4), 1468-1472. Hodgkinson, A. J., Cannon, R. D., Holmes, A. R., Fischer, F. J., & Willix-Payne, D. J. (2007). Production from dairy cows of semi-industrial quantities of milk-protein concentrate (MPC) containing efficacious anti-Candida albicans IgA antibodies. Journal of Dairy Research, 74, 269-275. Ichim, I., Kieser, J. A., & Swain, M. V. (2007). Functional significance of strain distribution in the human mandible under masticatory load: Numerical predictions. Archives of Oral Biology, 52, 465-473. Ichim, I., Li, Q., Li, W., Swain, M. V., & Kieser, J. (2007). Modelling of fracture behaviour in biomaterials. Biomaterials, 28, 1317-1326. Ichim, I., Li, Q., Loughran, J., Swain, M. V., & Kieser, J. (2007). Restoration of non-carious cervical lesions: Part I. Modelling of restorative fracture. Dental Materials, 23, 1553-1561. Ichim, I. P., Schmidlin, P. R., Li, Q., Kieser, J. A., & Swain, M. V. (2007). Restoration of non-carious cervical lesions: Part II. Restorative material selection to minimise fracture. Dental Materials, 23, 1562-1569. Ichim, I., Schmidlin, P. R., Kieser, J. A., & Swain, M. V. (2007). Mechanical evaluation of cervical glass-ionomer restorations: 3D finite element study. Journal of Dentistry, 35, 28-35. Kieser, J. A., Bernal, V., Waddell, J. N., & Raju, S. (2007). The uniqueness of the human anterior dentition: A geometric morphometric analysis. Journal of Forensic Sciences, 52(3), 671-677. Lamping, E., Monk, B. C., Niimi, K., Holmes, A. R., Tsao, S., Tanabe, K., Niimi, M., Uehara, Y., & Cannon, R. D. (2007). Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae. Eukaryotic Cell, 6(7), 1150-1165. Maki, K., Holmes, A. R., Watabe, E., Iguchi, Y., Matsumoto, S., Ikeda, F., Tawara, S., & Mutoh, S. (2007). Direct comparison of the pharmacodynamics of four antifungal drugs in a mouse model of disseminated candidiasis using microbiological assays of serum drug concentrations. Microbiology and Immunology, 51(11), 1053-1059. Manakil, J. F., Seymour, G. J., & Bartold, P. M. (2007). Effect of cytokine and antigen stimulation on peripheral blood lymphocyte syndecan-1 expression. Oral Microbiology and Immunology, 22(4), 272-276. Miller, J. C., Grant, A. M., Drummond, B. F., Williams, S. M., Taylor, R. W., & Goulding, A. (2007). DXA measurements confirm that parental perceptions of elevated adiposity in young children are poor. Obesity, 15(1), 165-171. Moffat, S. M. (2007). Miss Marion Falconer: Pioneer dental nurse. DTA: Official Journal of the New Zealand Dental Therapists’ Association Incorporated, 14, 12-15. Nicolau, B., Thomson, W. M., Steele, J. G., & Allison, P. J. (2007). Life-course epidemiology: concepts and theoretical models and its relevance to chronic oral conditions. Community Dentistry and Oral Epidemiology, 35, 241-249. Odgers, C. L., Caspi, A., Broadbent, J. M., Dickson, N., Hancox, R. J., Harrington, H., Poulton, R., Sears, M. R., Thomson, W. M., & Moffitt, T. E. (2007). Prediction of differential adult health burden by conduct problem subtypes in males. Archives of General Psychiatry, 64, 476-484. Orozco A, Gemmell E, Bickel M, Seymour GJ. (2007). Interleukin 18 and periodontal disease. Crit Reviews in Oral Biol Med, J Dent Res: 86;586-593. Pongnarisorn, N. J., Gemmell, E., Tan, A. E. S., Henry, P. J., Marshall, R. I., & Seymour, G. J. (2007). Inflammation associated with implants with different surface types. Clinical Oral Implants Research, 18(1), 114-125. Ponnambalam, Y., Love, R. M., & Thomson, W. M. (2007). Bacterial chemoprophylaxis knowledge and practice among New Zealand dentists. New Zealand Dental Journal, 103(3), 51-57. Rautemaa R, Lauhio A, Cullinan M, Seymour G. (2007). Oral infections and systemic disease – an emerging problem in medicine. Clinical Microbiology and Infection; 13(11):1041-1047. Samotoi, A., Moffat, S. M., & Thomson, W. M. (2007). Musculoskeletal symptoms in NZ dental therapists 12-month prevalence and associations. DTA: Official Journal of the New Zealand Dental Therapists’ Association Incorporated, 14, 4-5. Seymour GJ. (2007). You cannot have good general health without good oral health. NZDJ:103;26-27

Division of HEALTH SCIENCES 121 Seymour GJ. (2007). Good oral health is essential for good general health: The oral systemic connection. Clinical Microbiology and Infection 13 (Suppl. 4):1-2. Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K. (2007). Relationship between periodontal infections and systemic disease. Clinical Microbiology and Infection 13 (Suppl. 4):3-10. Shearer, D. M., MacLeod, R. J., & Thomson, W. M. (2007). Oral-health-related quality of life: An overview for the general dental practitioner. New Zealand Dental Journal, 103(4), 82-87. Sosroseno, W., Musa, M., Ravichandran, M., Fikri Ibrahim, M., Bird, P. S., & Seymour, G. J. (2007). Effect of L-N6-(1- iminoethyl)-lysine, an inducible nitric oxide synthase inhibitor, on murine immune response induced by Actinobacillus actinomycetemcomitans lipopolysaccharide. Journal of Periodontal Research, 42(2), 124-130. Tanabe, K., Lamping, E., Adachi, K., Takano, Y., Kawabata, K., Shizuri, Y., Niimi, M., & Uehara, Y. (2007). Inhibition of fungal ABC transporters by unnarmicin A and unnarmicin C, novel cyclic peptides from marine bacterium. Biochemical and Biophysical Research Communications, 364, 990-995. Thomson, W. M. (2007). Measuring change in dry-mouth symptoms over time using the Xerostomia Inventory. Gerodontology, 24, 30-35. Thomson, W. M., Broadbent, J. M., Welch, D., Beck, J. D., & Poulton, R. (2007). Cigarette smoking and periodontal disease among 32-year-olds: A prospective study of a representative birth cohort. Journal of Clinical Periodontology, 34, 828-834. Thomson, W. M., Poulton, R., Hancox, R. J., Ryan, K. M., & Al-Kubaisy, S. (2007). Changes in medication use from age 26 to 32 in a representative birth cohort. Internal Medicine Journal, 37, 543-549. Wescott, D. C., Pinkerton, M. N., Gaffey, B. J., Beggs, K. T., Milne, T. J., & Meikle, M. C. (2007). Osteogenic gene expression by human periodontal ligament cells under cyclic tension. Journal of Dental Research, 86(12), 1212-1216.

Journal – Research Other Dearing, S., Healey, D., & Kean, M. (2007). Benefits and risks of orthodontic treatment: Report of the 2005 NZAO Symposium. New Zealand Dental Journal, 103(2), 28-33. Hamlet, S. M., Taiyeb-Ali, T. B., Cullinan, M. P., Westerman, B., Palmer, J. E., & Seymour, G. J. (2007). Tannerella forsythensis prtH genotype and association with periodontal status. Journal of Periodontology, 78(2), 344-350. Rautemaa, R., Lauhio, A., Cullinan, M. P., & Seymour, G. J. (2007). Oral infections and systemic disease: An emerging problem in medicine. Clinical Microbiology and Infection, 13(11), 1041-1047. Seymour, G. J., Ford, P. J., Cullinan, M. P., Leishman, S., & Yamazaki, K. (2007). Relationship between periodontal infections and systemic disease. Clinical Microbiology and Infection, 13(Suppl. 4), 3-10. Wong, B. K. J., Leichter, J. W., Chandler, N. P., Cullinan, M. P., & Holborow, D. W. (2007). Radiographic study of ethnic variation in alveolar bone height among New Zealand dental students. Journal of Periodontology, 78(6), 1070-1074.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF ANATOMY AND STRUCTURAL BIOLOGY

Authored Book – Research Jones, G. (2007). Bioethics: When the challenges of life become too difficult. Adelaide, Australia: ATF Press, 255p. Miller, R. (2007) A theory of the basal ganglia and their disorders, CRC Press, Roca Baton, USA, 312pp. Miller, R. (2007) A Neurodynamic Theory of Schizophrenia and Related Disorders, Lulu Enterprises, Morrisville, NC, USA, 618pp.

Chapter in Book – Research Boren, L., Gemmell, N.J. and Barton, K. (2007) The role and presence of a guide: preliminary findings from swim with seal programmes and land-based seal viewing in New Zealand. 366-380, Auckland, New Zealand. Clarkson, A. N. and Appleton, I. Cerebral hypoxia-ischemia-induced neuronal and cardiac impairment. In: Hypoxia and the Central Nervous System. Kaur, C. (ed). Transworld Research Network, (2007) 1-35. Domett, K. and Tayles, N. (2007) Population Health from the Bronze to the Iron Age in the Mun River Valley, Northeast Thailand. Cohen, M. and Crane-Kramer, G.N.N.. 286-299, University of Florida. Jones, D. G. and Galvin, K. A. Human Reproductive Cloning. In: Principles of Health Care Ethics. Ashcroft, R. E., Dawson, A., Draper, H. and McMillan, J. R. (ed). John Wiley, (2007) 759-765. Jones, D. G. and Galvin, K. A. Neural grafting in Parkinson’s disease: scientific and ethical pitfalls on the road from basic science to clinical reality. In: Research Communications in Biological Psychology, Psychiatry and Neurosciences 30-31 Mori, A. and Siva Sanka, D.V. (ed) PJD Publications Ltd (2007) 75-101. Stringer, M. D. Genitalia. In: Illustrated Textbook of Paediatrics. Third Edition T. Lissauer and G Clayden (ed). Mosby, (2007) 329-336. Stringer, M.D. (2007) Liver transplantation for liver tumours. Gupta, D.K. and Carachi, R.. 543-557, New Delhi, Jaypee Brothers Medical Publishers. Tayles, N., Halcrow, S. E. and Domett, K. XVIL The people of Noen U-Loke. In: The Origins of the Civilization of Angkor. Vol II. Higham, C. F. W., Kijngam, A., Talbot, S. (ed), (2007) 244-304.

122 RESEARCH REPORT 2007/2008 Chapter in Book – Textbook & Other Assinder, S. J., & Nicholson, H. D. (2007). Prostate disease: Prostate hyperplasia, prostate cancer, and prostatitis. In R. R. Kandeel, R. S. Swerdloff, & J . L. Pryor (Eds.), Male reproductive dysfunction: Pathophysiology and treatment (pp. 499- 518). New York: Informa Healthcare USA. Nicholson, H. D., & Assinder, S. J. (2007). Physiology of the prostate. In R. R. Kandeel, R. S. Swerdloff, & J . L. Pryor (Eds.), Male reproductive dysfunction: Pathophysiology and treatment (pp. 81-91). New York: Informa Healthcare USA.

Journal – Research Article Anas, M-K. I., Hammer, M-A., Lever, M., Stanton, J-A. L., & Baltz, J. M. (2007). The organic osmolytes betaine and proline are transported by a shared system in early preimplantation mouse embryos. Journal of Cellular Physiology, 210, 266-277. Arbuthnott, G. W., & Wickens, J. (2007). Space, time and dopamine. Trends in Neurosciences, 30(2), 62-69. Assinder, S., Davis, R., Fenwick, M., & Glover, A. (2007). Adult-only exposure of male rats to a diet of high phytoestrogen content increases apoptosis of meiotic and post-meiotic germ cells. Reproduction, 133, 11-19. Bentley, R. A., Buckley, H. R., Spriggs, M., Bedford, S., Ottley, C. J., Nowell, G. M., Macpherson, C. G., & Pearson, D. G. (2007). Lapita migrants in the Pacific’s oldest cemetery: Isotopic analysis at Teouma, Vanuatu. American Antiquity, 72(4), 645-656. Bentley, R. A., Tayles, N., Higham, C., Macpherson, C., & Atkinson, T. C. (2007). Shifting gender relations at Khok Phanom Di, Thailand: Isotopic evidence from the skeletons. Current Anthropolgy, 48(2), 301-314. Brown, C. H., & Grattan, D. R. (2007). Does maternal oxytocin protect the fetal brain? Trends in Endocrinology and Metabolism, 18(6), 225-226. Buckley, H. R. (2007). Possible gouty arthritis in Lapita-associated skeletons from Teouma, Efate Island, Central Vanuatu. Current Anthropology, 48(5), 741-749. Carrington, E., Kokay, I. C., Duthie, J., Lewis, R., & Mercer, A. R. (2007). Manipulating the light/dark cycle: Effects on dopamine levels in optic lobes of the honey bee (Apis mellifera) brain. Journal of Comparative Physiology A, 193(2), 167-180. Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561. Clarkson, A. N., Liu, H., Schiborra, F., Shaw, O., Sammut, I. A., Jackson, D. M., & Appleton, I. (2007). Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research, 1171, 111-121. Clements, K. M., Saunders, A. J., Robertson, B-A., & Wainwright, P. E. (2007). Spontaneously hypertensive, Wistar Kyoto and Sprague-Dawley rats differ in their use of place and response strategies in the water radial arm maze. Neurobiology of Learning and Memory, 87, 285-294. Clements, K. M., & Wainwright, P. E. (2007). Spontaneously hpertensive, Wistar Kyoto and Sprague-Dawley rats differ in performance on a win-stay task and a conditioned cue preference task in the water radial arm maze. Behavioural Brain Research, 183, 169-177. Covey, M. V., & Oorschot, D. E. (2007). Effect of hypothermic post-treatment on hypoxic-ischemic striatal injury, and normal striatal development, in neonatal rats: A stereological study. Pediatric Research, 62(6), 646-651. Davenport, M., Stringer, M. D., Tizzard, S. A., McClean, P., Mieli-Vergani, G., & Hadzic, N. (2007). Randomized, double-blind, placebo-controlled trial of corticosteroids after Kasai portoenterostomy for biliary atresia. Hepatology, 46, 1821-1827. Deng, X-f., Han, H., Tao, W., Pang, G., Liu, K-p., Liu, B., Chen, F-h., & Zhang, M. (2007). Microanatomy of the Labb é veins and their venograms obtained by imageology. Acta Anatomica Sinica, 38(6), 759-764. Dennison, J. (2007). Polynesian dentition. Anthropologischer Anzeiger, 65(4), 353-363. Dennison, J., Healey, D., & Herbison, P. (2007). The Polynesian chin and mandible. Anthropologischer Anzeiger, 65, 241-252. Dennison, K. J., & Dias, G. J. (2007). The posterior deep temporal nerve: Its relationship with the human cranial base. Clinical Anatomy, 20(2), 126-130. Dias, G. J., Prasad, K., & Santos, A. L. (2007). Pathogenesis of apical periodontal cysts: Guidelines for diagnosis in palaeopathology. International Journal of Osteoarchaeology, 17, 619-626. Feng, L., Sun, Z., Han, H., Zhou, Y., & Zhang, M. (2007). No age-related cell loss in three retinal nuclear layers of the Long- Evans rat. Visual Neuroscience, 24, 799-803. Fleming, J. S., McQuillan, H. J., Millier, M. J., Beaugié, C. R., & Livingstone, V. (2007). E-cadherin expression and bromodeoxyuridine incorporation during development of ovarian inclusion cysts in age-matched breeder and incessantly ovulated CD-1 mice. Reproductive Biology and Endocrinology, 5. http://www.rbej.com/content/pdf/1477-7827-5-14.pdf Gould, M. L., Hurst, P. R., & Nicholson, H. D. (2007). The effects of oestrogen receptors alpha and beta on testicular cell number and steroidogenesis in mice. Reproduction, 134, 271-279. Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351. Grattan, D. R., Ladyman, S. R., & Augustine, R. A. (2007). Hormonal induction of leptin resistance during pregnancy. Physiology & Behavior, 91, 366-374. Halcrow, S. E., Tayles, N., & Buckley, H. R. (2007). Age estimation of children from prehistoric Southeast Asia: Are the dental formation methods used appropriate? Journal of Archaeological Science, 34, 1158-1168. Han, H., Tao, W., & Zhang, M. (2007). The dural entrance of cerebral bridging veins into the superior sagittal sinus: An anatomical comparison between cadavers and digital subtraction angiography. Neuroradiology, 49, 169-175. Hesp, B. R., Clarkson, A. N., Sawant, P. M., & Kerr, D. S. (2007). Domoic acid preconditioning and seizure induction in young and aged rats. Epilepsy Research, 76, 103-112.

Division of HEALTH SCIENCES 123 Humphrey, T., Bainbridge, C., & Stringer, M. (2007). Reproducibility of measurements of hepatic artery and portal vein diameter and flow velocity in paediatric liver transplant recipients. Pediatric Surgery International, 37, 813-817. Humphrey, T. M., & Stringer, M. D. (2007). Biliary Atresia: US diagnosis. Radiology, 244(3), 845-851. Jones, D. G. (2007). Anatomical investigations and their ethical dilemmas. Clinical Anatomy, 20, 338-343. Jones, D. G., & Whitaker, M. I. (2007). The tenuous world of plastinates. American Journal of Bioethics, 7(4), 27-29. Josephs, T., Waugh, H., Kokay, I., Grattan, D., & Thompson, M. (2007). Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. Journal of Endocrinology, 194, 305-312. Li, C., Stanton, J-A. L., Robertson, T. M., Suttie, J. M., Sheard, P. W., Harris, A. J., & Clark, D. E. (2007). Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus). PLoS ONE, 2(1). http://www.plosone.org/ article/info%3Adoi%2F10.1371%2Fjournal.pone.0000148 Li, S., Arbuthnott, G. W., Jutras, M. J., Goldberg, J. A., & Jaeger, D. (2007). Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation. Journal of Neurophysiology, 98, 3525-3537. Liu, K., Deng, X., Han, H., Bin, G., & Zhang, M. (2007). Morphological investigation on olfactory nerve and its clinical significance. Chinese Journal of Clinical Anatomy, 25(6), 618-621. Lord, E. A., Martin, S. K., Gray, J. P., Li, C., & Clark, D. E. (2007). Cell cycle genes PEDF and CDKN1C in growing deer antlers. Anatomical Record, 290, 994-1004. McDonald, R. M., Smith, J. F., Montgomery, G. W., Fleming, J. S., & Cox, N. R. (2007). Sperm DNA damage after scrotal insulation in rams. Proceedings of the New Zealand Society of Animal Production, 67, 192-197. Miller, R. (2007). Theory of the normal waking EEG: From single neurones to waveforms in the alpha, beta and gamma frequency ranges. International Journal of Psychophysiology, 64, 18-23. Mockett, B. G., Guévremont, D., Williams, J. M., & Abraham, W. C. (2007). Dopamine D1/D5 receptor activation reverses NMDA receptor-dependent long-term depression in rat hippocampus. The Journal of Neuroscience, 27(11), 2918-2926. Möderscheim, T. A. E., Gorba, T., Pathipati, P., Kokay, I. C., Grattan, D. R., Williams, C. E., & Scheepens, A. (2007). Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience, 145, 963-973. Newsham-West, R., Nicholson, H., Walton, M., & Milburn, P. (2007). Long-term morphology of a healing bone-tendon interface: A histological observation in the sheep model. Journal of Anatomy, 210, 318-327. Nicholson, H. D., & Whittington, K. (2007). Oxytocin and the human prostate in health and disease. International Review of Cytology, 263, 253-286. Oorschot, D. E., Voss, L., Covey, M. V., Bilkey, D. K., & Saunders, S. E. (2007). ADHD-like hyperactivity, with no attention deficit, in adult rats after repeated hypoxia during the equivalent of extreme prematurity. Journal of Neuroscience Methods, 166, 315-322. Pitcher, T. L., Wickens, J. R., & Reynolds, J. N. J. (2007). Differences in striatal spiny neuron action potentials between the Spontaneously Hypertensive and Wistar-Kyoto Rat strains. Neuroscience, 146, 135-142. Richardson, C. A., & Leitch, B. (2007). Identification of the neurotransmitters involved in modulation of transmitter release from the central terminals of the locust wing hinge stretch receptor. Journal of Comparative Neurology, 502, 794-809. Rogers, T. N., Woodley, H., Ramsden, W., Wyatt, J. I., & Stringer, M. D. (2007). Solitary liver cysts in children: Not always so simple. Journal of Pediatric Surgery, 42, 333-339. Sayers, C., Wyatt, J., Soloway, R. D., Taylor, D. R., & Stringer, M. D. (2007). Gallbladder mucin production and calcium carbonate gallstones in children. Pediatric Surgery International, 23, 219-223. Sibanda, N., Lewsey, J. D., van der Meulen, J. H. P., & Stringer, M. D. (2007). Continuous monitoring tools for pediatric surgical outcomes: An example using biliary atresia. Journal of Pediatric Surgery, 42, 1919-1925. Sole, G., Hamrén, J., Milosavljevic, S., Nicholson, H., & Sullivan, S. J. (2007). Test-retest reliability of isokinetic knee extension and flexion. Archives of Physical Medicine and Rehabilitation, 88, 626-631. Stanton, J-A. L., Macgregor, A. B., Mason, C., Dameh, M., & Green, D. P. L. (2007). Building comparative gene expression databases for the mouse preimplantation embryo using a pipeline approach to UniGene. Molecular Human Reproduction, 13(10), 713-720. Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Differential effects of centrally-administered oestrogen antagonist ICI- 182,780 on oestrogen-sensitive functions in the hypothalamus. Journal of Neuroendocrinology, 19(1), 26-33. Steyn, F. J., Anderson, G. M., & Grattan, D. R. (2007). Expression of ovarian steroid hormone receptors in tuberoinfundibular dopaminergic neurones during pregnancy and lactation. Journal of Neuroendocinology, 19(10), 788-793. Stringer, M. D. (2007). Improved body mass index after mesenterico-portal bypass. Pediatric Surgery International, 23, 539-543. Stringer, M. D. (2007). Wide hilar hepatico-jejunostomy: The optimum method of reconstruction after choledochal cyst excision. Pediatric Surgery International, 23, 529-532. Stringer, M. D., Davison, S. M., Rajwal, S. R., & McClean, P. (2007). Kasai portoenterostomy: 12-year experience with a novel adjuvant therapy regimen. Journal of Pediatric Surgery, 42, 1324-1328. Stringer, M. D., Soloway, R. D., Taylor, D. R., Riyad, K., & Toogood, G. J. (2007). Calcium carbonate gallstones in children. Journal of Pediatric Surgery, 42, 1677-1682. Sun, Z-x., Feng, L-x., Zhang, M., Huank, D-k., & Han, H. (2007). Aging effect on the thickness of the whole retina and its sublayers: A stereology study. Acta Anatomica Sinica, 38(2), 187-191. Tao, W., Han, H., Jiao, Y., Deng, X., Zhu, Y., & Zhang, M. (2007). Morphological investigation on the terminal segments of superior cerebral vein draining into superior sagittal sinus. Chinese Journal of Clinical Anatomy, 25(2), 132-135.

124 RESEARCH REPORT 2007/2008 Wang, P-Y., Koishi, K., & McLennan, I. S. (2007). BMP6 is axonally transported by motoneurons and supports their survival in vitro. Molecular and Cellular Neuroscience, 34, 653-661. Wang, Q., Xu, S., Tu, L., Liu, Y., & Zhang, M. (2007). Anatomic continuity of longitudinal pharyngeal and esophageal muscles. Laryngoscope, 117, 282-287. Whittington, K., Connors, B., King, K., Assinder, S., Hogarth, K., & Nicholson, H. (2007). The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: Implications for benign prostatic hyperplasia and carcinoma of the prostate. Prostate, 67, 1132-1142. Wickens, J. R., Arbuthnott, G. W., & Shindou, T. (2007). Simulation of GABA function in the basal ganglia: Computational models of GABAergic mechanisms in basal ganglia function. Progress in Brain Research, 160, 313-329. Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. The Journal of Neuroscience, 27(51), 14171-14178. Woodley, S. J., Duxson, M. J., & Mercer, S. R. (2007). Preliminary observations on the microcarchitechture of the human abdominal muscles. Clinical Anatomy, 20, 808-813. Wright, A. K., & Arbuthnott, G. W. (2007). The influcence of the subthalamic nucleus upon the damage to the dopamine system following lesions of globus pallidus in rats. European Journal of Neuroscience, 26, 642-648. Young, A. G., Green, D. P., & McQuillan, A. J. (2007). IR spectroscopic studies of adsorption of dithiol-containing ligands on CdS nanocrystal films in aqueous solutions. Langmuir, 23, 12923-12931. Zhu, X., Wang, Q., Tu, L., Liu, Y., Zhou, Q., Zhang, M., & Xu, S. (2007). Three-dimensional distribution of 〈-SMA, MHC- ⊃ and MHC- ⊃⊃ in muscular layer of pharynx and esophagus in human fetus. Chinese Journal of Anatomy, 30(1), 34-38.

Journal – Research Other Clarkson, A. N. (2007). Anesthetic-mediated protection/preconditioning during cerebral ischemia. Life Sciences, 80, 1157-1175. Wickens, J. R., Budd, C. S., Hyland, B. I., & Arbuthnott, G. W. (2007). Striatal contributions to reward and decision making: Making sense of regional variations in a reiterated processing matrix. Annals of the New York Academy of Sciences, 1104, 192-212.

Journal – Professional & Other Non-Research Articles Storr, E. F., de Vere Beavis, F. O., & Stringer, M. D. (2007). Texting tenosynovitis [Case notes]. The New Zealand Medical Journal, 120(1267). http://www.nzma.org.nz/journal/120-1267/2868/ Stringer, M. D. (2007). The role of liver transplantation in the management of paediatric liver tumours. Annals of the Royal College of Surgeons of England, 89, 12-21.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF BIOCHEMISTRY

Journal – Research Article Aguilar-Rosas, R., Aguilar-Rosas, L. E., Sánchez-Rodrígue, I., Broom, J. E., & Nelson, W. A. (2007). Morphology and distribution of Porphyra hollenbergii (Bangiaceae, Rhodophyta) in the Pacific coast of México. Revista Mexicana de Biodiversidad, 78, 351-357. Carlton, T. M., Sullivan, J. T., Stuart, G. S., Hutt, K., Lamont, I. L., & Ronson, C. W. (2007). Ferrichrome utilization in a mesorhizobial population: Microevolution of a three-locus system. Environmental Microbiology, 9(12), 2923-2932. Chen, C., Beck, B. W., Krause, K., Weksberg, T. E., & Pettitt, B. M. (2007). Effects of dimerization of Serratia marcescens endonuclease on water dynamics. Biopolymers, 85(3), 241-252. Chyou, D. T., Rawle, V. L., & Trotman, C. N. A. (2007). Quaternary structure of Artemia haemoglobin II: Analysis of T and C polymer alignment and interpolymer interface. BMC Structural Biology, 7(26). http://www.biomedcentral.com/1472- 6807/7/26 Clark, M. B., Jänicke, M., Gottesbühren, U., Kleffmann, T., Legge, M., Poole, E. S., & Tate, W. P. (2007). A mammalian gene PRG10 expresses two reading frames by high efficiency -1 frameshifting in embryonic-associated tissues. Journal of Biological Chemistry, 282(52), 37359-37369. Cochemé, H. M., Kelso, G. F., James, A. M., Ross, M. F., Trnka, J., Mahendiran, T., Asin-Cayuela, J., Blaikie, F. H., Manas, A-R. B., Porteous, C. M., Adlam, V. J., Smith, R. A. J., & Murphy, M. P. (2007). Mitochondrial targeting of quinones: Therapeutic implications. Mitochondrion, 7S, S94-S102. Counago, R., Wilson, C.J., Pena, M.I., Wittung-Stafshede, P. & Shamoo, Y. (2007). An adaptive mutation in adenylate kinase that increases organismal fitness is linked to stability-activity trade-offs. Protein Engineering Design and Selection, 21(1), 19-27. Cutfield, W. S., Hofman, P. L., Mitchell, M., & Morison, I. M. (2007). Could epigenetics play a role in the developmental origins of health and disease? Pediatric Research, 61(5), 68R-75R. Czabotar, P. E., Lee, E. F., van Delft, M. F., Day, C. L., Smith, B. J., Huang, D. C. S., Fairlie, F. D., Hinds, M. G., & Colman, P. M. (2007). Structural insights into the degradation of Mcl-1 induced by BH3 domains. PNAS, 104(15), 6217-6222.

Division of HEALTH SCIENCES 125 Day, R. C., McNoe, L. A., & Macknight, R. C. (2007). Evaluation of global RNA amplification and its use for high-throughput transcript analysis of laser-microdissected endosperm. International Journal of Plant Genomics, 2007. Day, R. C., McNoe, L. A., & MacKnight, R. C. (2007). Transcript analysis of laser microdissected plant cells. Physiologia Plantarum, 129(2), 267-282. Diggle, S. P., Matthijs, S., Wright, V. J., Fletcher, M. P., Chhabra, S. R., Lamont, I. L., Kong, X., Hider, R. C., Cornelis, P., Cámara, M., & Williams, P. (2007). The Pseudomonas aeruginosa 4-quinolone signal molecules HHQ and PQS play multifunctional roles in quorum sensing and iron entrapment. Chemistry & Biology, 14, 87-96. Duncan, E. J., Dodds, K. G., Henry, H. M., Thompson, M. P., & Puha, S. H. (2007). Cloning, mapping and association studies of the ovine ABCG2 gene with facial eczema disease in sheep. Animal Genetics, 38, 126-131. Eaton-Rye, J. J. (2007). Celebrating Govindjee’s 50 years in photosynthesis research and his 75th birthday. Photosynthesis Research, 93, 1-5. Eaton-Rye, J. J. (2007). Snapshots of the Govindjee lab from the late 1960s to the late 1990s, and beyond... Photosynthesis Research, 94, 153-178. Frank, N., Fitzgerald, R., & Legge, M. (2007). Phenylketonuria-the lived experience. The New Zealand Medical Journal, 120(1262). Frank, N., Fitzgerald, R. P., & Legge, M. (2007). Negotiating PKU: Insights from New Zealand. Sites, 4(1), 161-189. Fukuzawa, R., Heathcott, R. W., More, H. E., & Reeve, A. E. (2007). Sequential WT1 and CTNNB1 mutations and alterations of beta-catenin localisations in intralobar nephrogenic rests and associated Wilms tumours; Two case studies. Journal of Clinical Pathology, 60, 1013-1016. Fukuzawa, R., & Reeve, A. E. (2007). Molecular pathology and epidemiology of nephrogenic rests and wilms tumors. Journal of Pediatric Hematology/Oncology, 29(9), 589-594. Gil, M., McKinney, C. Z., Lee, M. K., Eells, J. B., Phyillaier, M. A., & Nikodem, V. M. (2007). Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo. Journal of Neurochemistry, 101, 142-150. Goodwin, T. J. D., Busby, J. N., & Poulter, R. T. M. (2007). A yeast model for target-primed (non-LTR) retrotransposition. BMC Genomics, 263(8). http://www.biomedcentral.com/content/pdf/1471-2164-8-263.pdf Hinds, M. G., Smits, C., Fredericks-Short, R., Risk, J. M., Bailey, M., Huang, D. C. S., & Day, C. L. (2007). Bim, Bad and Bmf: Intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death and Differentiation, 14, 128-136. Hong, J., Leung, E., Fraser, A. G., Merriman, T. R., Vishnu, P., & Krissansen, G. W. (2007). TLR2, TLR4 and TLR9 polymorphisms and Crohn’s disease in a New Zealand caucasian cohort. Journal of Gastroenterology and Hepatology, 22, 1760-1766. Hong, J., Leung, E., Fraser, A. G., Merriman, T. R., Vishnu, P., & Krissansen, G. W. (2007). Polymorphisms in NFKBIA and ICXAM-1 genes in New Zealand caucasian Crohn’s disease patients. Journal of Gastroenterology and Hepatology, 22, 1666-1670. Humar, B., Fukuzawa, R., Blair, V., Dunbier, A., More, H., Charlton, A., Yang, H. K., Kim, W. H., Reeve, A. E., Martin, I., & Guilford, P. (2007). Destabilized adhesion in the gastric proliferative zone and c-Src kinase activation mark the development of early diffuse gastric cancer. Cancer Research, 67(6), 2480-2489. Ito, M., Nishiyama, H., Kawanishi, H., Matsui, S., Guilford, P., Reeve, A., & Ogawa, O. (2007). P21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. Journal of Urology, 178, 1073-1079. Janko, K., Lecointre, G., DeVries, A., Couloux, A., Cruaud, C., & Marshall, C. (2007). Did glacial advances during the Pleistocene influence differently the demographic histories of benthic and pelagic Antarctic shelf fishes? Inferences from intraspecific mitochondrial and nuclear DNA sequence diversity. BMC Evolutionary Biology, 7. http://www. biomedcentral.com/content/pdf/1471-2148-7-220.pdf Janko, K., Lecointre, G., Devries, A. L., Couloux, A., Cruaud, C., & Marshall, C. (2007). Expression of Krüppel-like factor 5 in human gastric carcinomas. BMC Evolutionary Biology, 7(220). http://www.biomedcentral.com/1471-2148/7/220 Jarvis, R., Göttert, J., Murphy, M. P., & Ledgerwood, E. C. (2007). Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells. Free Radical Research, 41(9), 1041-1046. Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685. Josephs, T., Waugh, H., Kokay, I., Grattan, D., & Thompson, M. (2007). Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat. Journal of Endocrinology, 194, 305-312. Juntarajumnong, W., Eaton-Rye, J. J., & Incharoensakdi, A. (2007). Two-component signal transduction in Synechocystis sp. PCC 6803 under phosphate limitation: Role of acetyl phosphate. Journal of Biochemistry and Molecular Biology, 40(5), 708-714. Juntarajumnong, W., Hirani, T. A., Simpson, J. M., Incharoensakdi, A., & Eaton-Rye, J. J. (2007). Phosphate sensing in Synechocystis sp. PCC 6803: SphU and the SphU-SphR two-component regulatory system. Archives of Microbiology, 188, 389-402. Juntarajumnong, W., Incharoensakdi, A., & Eaton-Rye, J. J. (2007). Identification of the start codon for sphS encoding the phosphate-sensing histidine kinase in Synechocystis sp. PCC 6803. Current Microbiology, 55, 142-146. Keane, O. M., Dodds, K. G., Crawford, A. M., & McEwan, J. C. (2007). Transcriptional profiling of Ovis aries identifies Ovar-DQA1 allele frequency differences between nematode-resistant and susceptible selection lines. Physiological Genomics, 30, 253-261.

126 RESEARCH REPORT 2007/2008 Kerruish, N. J., Campbell-Stokes, P. L., Gray, A., Merriman, T. R., Robertson, S. P., & Taylor, B. J. (2007). Maternal psychological reaction to newborn genetic screening for type 1 diabetes. Pediatrics, 120(2), e324-e335. Kim, D., Jitrapakdee, S., & Thompson, M. (2007). Differential regulation of the promoter activity of the mouse UCP2 and UCP3 genes by MyoD and myogenin. Journal of Biochemistry and Molecular Biology, 40(6), 921-927. Kwak, M.K., Lee, H-J., Hur, K., Park, D.J., Lee, H.S., Kim, W.H., Lee, K.U., Choe, K.J., Guilford, P. & Yang, H-K. (2007). Expression of Krüppel-like factor 5 in human gastric carcinomas. J Cancer Res Clin Oncol, 134(2), 163-167. Lamare, M. D., Barker, M. F., Lesser, M. P., & Marshall, C. (2007). DNA photorepair in echinoid embryos: Effects of temperature on repair rate in Antarctic and non-Antarctic species. The Journal of Experimental Biology, 209, 5017-5028. Lee, M. A., Manley, T. R., Glass, B. C., Anderson, R. M., Wilson, S. J., O’Keefe, J. S., Tisdall, D. J., McEwan, J. C., Phua, S. H., & Tate, M. L. (2007). Distribution of prion protein genotypes in breeds of sheep in New Zealand. New Zealand Veterinary Journal, 55(5), 222-227. Legge, M., & Fitzgerald, R. (2007). Risky knowledges: The sociocultural impacts of personal genetics in a knowledge-driven economy. The New Zealand Medical Journal, 120(1262). http://www.nzma.org.nz/journal/120-1262/2736/ Legge, M., Fitzgerald, R., & Frank, N. (2007). A retrospective study of New Zealand case law involving assisted reproduction technology and the social recognition of ‘new’ family. Human Reproduction, 22(1), 17-25. Leung E, Hong J, Fraser AG, Merriman TR, Vishnu P, Krissansen GW. Peroxisome proliferator-activated receptor-gamma gene polymorphisms and Crohn’s disease. Int J Colorectal Dis. 22: 453-4, 2007. Leung E, Hong J, Fraser AG, Merriman TR, Vishnu P, Krissansen GW. Colony-stimulating factor-1 receptor gene polymorphisms and Crohn’s disease. Int J Colorectal Dis. 22: 995-6, 2007. Lin, H-M., Chatterjee, A., Lin, Y-H., Anjomshoaa, A., Fukuzawa, R., McCall, J. L., & Reeve, A. E. (2007). Genome wide expression profiling identifies genes associated with colorectal liver metastasis. Oncology Reports, 6, 1541-1549. Lin, Y-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, L. V., Thompson-Fawcett, M., Kasabov, N., Toro, T., Merrie, A. E., van Rij, A., Yoon, H-S., McCall, J. L., Siewert, J. R., Holzmann, B., & Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clincial Cancer Research, 13(2), 498-507. Mace, P. D., Cutfield, J. F., & Cutfield, S. M. (2007). Bacterial expression and purification of the ovine type II bone morphogenetic protein receptor ectodomain. Protein Expression and Purification, 52(1), 40-49. Matsui, S., Ito, M., Nishiyama, H., Uno, H., Kotani, H., Watanabe, J., Guilford, P., Reeve, A., Fukushima, M., & Ogawa, O. (2007). Genomic characterization of multiple clinical phenotypes of cancer using multivariate linear regression models. Bioinformatics, 23(6), 732-738. McKinney, C. Z., & Merriman, T. R. (2007). The human genome and understanding of common disease: Present and future technologies. Cellular and Molecular Life Sciences, 64(7-8), 961-978. Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2007). The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine. Journal of Bacteriology, 189(22), 8381-8386. More, H., Humar, B., Weber, W., Ward, R., Christian, A., Lintott, C., Graziano, F., Ruzzo, A-M., Acosta, E., Harlan, M., Ferreira, P., Seruca, R., Suriano, G., & Guilford, P. (2007). Identification of seven novel germline mutations in the human E-cadherin (CDH1) gene. Human Mutation, 28(2). http://www3.interscience.wiley.com/homepages/38515/pdf/944.pdf Mountfort, D. O., Rhodes, L. L., Broom, J., Gladstone, M., & Tyrrell, J. (2007). Fluorescent in situ hybridisation assay as a species-specific identifier of the northern Pacific seastar, Asterias amurensis. New Zealand Journal of Marine and Freshwater Research, 41, 283-290. Owen, C. J., Kelly, H., Eden, J. A., Merriman, M. E., Pearce, S. H. S., & Merriman, T. R. (2007). Analysis of the Fc receptor-like-3 (FCRL3) locus in caucasians with autoimmune disorders suggests a complex pattern of disease association. The Journal of Clinical Endocrinology & Metabolism, 92(3), 1106-1111. Panjaworayan, N., Roessner, S. K., Firth, A. E., & Brown, C. M. (2007). HBVRegDB: Annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences. Virology Journal, 4. http://www.virologyj.com/ content/4/1/136 Pearl, E. J., Bokor, A. A. M., Butler, M. I., Poulter, R. T. M., & Wilbanks, S. M. (2007). Preceding hydrophobic and beta branched amino acids attenuate splicing by the CnePRP8 intein. Biochimica et Biophysica Acta, 1774, 995-1001. Pearl, E. J., Tyndall, J. D. A., Poulter, R. T. M., & Wilbanks, S. M. (2007). Sequence requirements for splicing by the Cne PRP8 intein. FEBS Letters, 581, 3000-3004. Poole, E. S., Young, D. J., Askarian-Amiri, M. E., Scarlett, D-J. G., & Tate, W. P. (2007). Accommodating the bacterial decoding release factor as an alien protein among the RNAs at the active site of the ribosome. Cell Research, 17, 591-607. Poulter, R. T. M., Goodwin, T. J. D., & Butler, M. I. (2007). The nuclear-encoded inteins of fungi. Fungal Genetics and Biology, 44(3), 153-179. Roberts, R., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., Timms, K. M., Gutin, A., Lanchbury, J. S., Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn’s disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology, 102, 2754-2761. Soleimanpour-Lichaei, H. R., Kühl, I., Gaisne, M., Passos, J. F., Wydro, M., Rorbach, J., Temperley, R., Bonnefoy, N., Tate, W., Lightowlers, R. N., & Chrzanowska-Lightowlers, Z. (2007). mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Molecular Cell, 27, 745-757.

Division of HEALTH SCIENCES 127 Steer, S., Abkevich, V., Gutin, A., Cordell, H. J., Gendall, K. L., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J., Stamp, L., Fitzgerald, L., Iliev, D., Kouzmine, A., Tran, T., Skolnick, M. H., Timms, K. M., Lanchbury, J. S., & Merriman, T. R. (2007). Genomic DNA pooling for whole-genome association scans in complex disease: Empirical demonstration of efficacy in rheumatoid arthritis. Genes and Immunity, 8, 57-68. Strych, U., Davlieva, M., Longtin, J. P., Murphy, E. L., Im, H., Benedik, M. J., & Krause, K. L. (2007). Purification and preliminary crystallization of alanine racemase from Streptococcus pneumoniae. BMC Microbiology, 7(40). http://www. biomedcentral.com/content/pdf/1471-2180-7-40.pdf Summerfield, T., Eaton-Rye, J. J., & Sherman, L. A. (2007). Global gene expression of a DeltaPsbU mutant and a spontaneous revertant in the cyanobacterium Synechocystis sp. strain PCC 6803. Photosynthesis Research, 94, 265-274. Swe, P. M., Heng, N. C. K., Ting, Y-T., Baird, H. J., Carne, A., Tauch, A., Tagg, J. R., & Jack, R. W. (2007). ef1097 and ypkK encode enterococcin V583 and corynicin JK, members of a new family of antimicrobial proteins (bacteriocins) with modular structure from Gram-positive bacteria. Microbiology, 153, 3218-3227. Turner, P. R., Bourne, K., Garama, D., Carne, A., Abraham, W. C., & Tate, W. P. (2007). Production, purification and functional validation of human secreted amyloid precursor proteins for use as neuropharmacological reagents. Journal of Neuroscience Methods, 164, 68-74. Upritchard, H. G., Yang, J., Bremer, P. J., Lamont, I. L., & McQuillan, A. J. (2007). Adsorption to metal oxides of the Pseudomonas aeruginosa siderophore pyoverdine and implications for bacterial biofilm formation on metals. Langmuir, 23(13), 7189-7195. van Stijn, T. C., French, M. C., Dodds, K. G., McEwan, J. C., Broad, T. E., Womack, J. E., Tisdall, D. J., & Galloway, S. M. (2007). Comparative mapping of sheep chromosome 2q. Cytogenetic and Genome Research, 116, 85-92. Visca, P., Imperi, F., & Lamont, I. L. (2007). Pyoverdine siderophores: From biogenesis to biosignificance. Trends in Microbiology, 15(11), 22-30. Weksberg, T. E., Lynch, G. C., Krause, K. L., & Pettitt, B. M. (2007). Molecular dynamics simulations of Trichomonas vaginalis ferredoxin show a loop-cap transition. Biophysical Journal, 92(10), 3337-3345. Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188. Wharton, D. A., Wilson, P. W., Mutch, J. S., Marshall, C. J., & Lim, M. (2007). Recrystallization inhibition assessed by splat cooling and optical recrystallometry. CryoLetters, 28(1), 61-68. Wilcox, S. J., Barr, N., Broom, J. E., Furneaux, R. H., & Nelson, W. A. (2007). Using gigartinine to track the distribution of an alien species of Gracilaria in New Zealand. Journal of Applied Phycology, 19, 313-323. Williams, J. M., Guévremont, D., Mason-Parker, S. E., Luxmanan, C., Tate, W. P., & Abraham, W. C. (2007). Differential trafficking of AMPA and NMDA receptors during long-term potentiation in awake adult animals. The Journal of Neuroscience, 27(51), 14171-14178. Wirawan, R. E., Swanson, K. M., Kleffmann, T., Jack, R. W., & Tagg, J. R. (2007). Uberlysin: A novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology, 153, 1619-1630. Zadissa, A., McEwan, J. C., & Brown, C. M. (2007). Inference of transcriptional regulation using gene expression data from the bovine and human genomes. BMC Genomics, 8, 265. http://www.pubmedcentral.nih.gov/picrender. fcgi?artid=1978505&blobtype=pdf Zheng, Y., Baek, J-h., Smith, P. F., & Darlington, C. L. (2007). Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. Hearing Research, 228, 105-111.

Journal – Research Other Guilford, P., Blair, V., More, H., & Humar, B. (2007). A short guide to hereditary diffuse gastric cancer. Hereditary Cancer in Clinical Practice, 5(4), 183-194. Leung, E., Hong, J., Fraser, A. G., Merriman, T. R., Vishnu, P., & Krissansen, G. W. (2007). Colony-stimulating factor-1 receptor gene polymorphisms and Crohn’s disease. International Journal of Colorectal Disease, 22(8), 995-996. Leung, E., Hong, J., Fraser, A. G., Merriman, T. R., Vishnu, P., & Krissansen, G. W. (2007). Peroxisome proliferator-activated receptor-gamma ene polymorphisms and Crohn’s disease. International Journal of Colorectal Disease, 22(4), 453-454.

Journal – Professional & Other Non-Research Articles Merriman, T., & Cameron, A. V. (2007). Risk-taking: Behind the warrior gene story. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2440/

128 RESEARCH REPORT 2007/2008 OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Edited Book - Research Mercer, A. A., Schmidt, A., & Weber, O. (Eds.). (2007). Poxviruses. Basel, Switzerland: Birkhäuser Verlag, 441p.

Chapter in Book – Research Fleming, S. B., & Mercer, A. A. (2007). Genus Parapoxvirus. In A. A. Mercer, A. Schmidt, & O. Weber (Eds.), Poxviruses (pp. 127-166). Basel, Switzerland: Birkhäuser Verlag. Heng, N. C., Wescombe, P. A., Burton, J. P., Jack, R. W., & Tagg, J. R. (2007). The diversity of bacteriocins in gram-positive bacteria. In M. A. Riley & M. A. Chavan (Eds.), Bacteriocins: Ecology and evolution (pp. 45-92). Berlin, Germany: Springer-Verlag. Tagg, J.R., Burton, J.P. Wescombe, P.A. 2007. Application of bacterial pathogens in replacement therapy. In: Patho- Biotechnology. Sleater, R. & Hill, C. (Eds), Landes Bioscience.

Journal – Research Article Akesson, M., Dufour, M., Sloan, G. L., & Simmonds, R. S. (2007). Targeting of streptococci by zoocin A. FEMS Microbiology Letters, 270, 155-161. Bannantine, J. P., Radosevich, T. J., Stabel, J. R., Berger, S., Griffin, J. F. T., & Paustian, M. L. (2007). Production and characterization of monoclonal antibodies against a major membrane protein of Mycobacterium avium subsp. paratuberculosis. Clinical and Vaccine Immunology, 14(3), 312-317. Berger, S., Bannantine, J. P., & Griffin, J. F. T. (2007). Autoreactive antibodies are present in sheep with Johne’s disease and cross-react with Mycobacterium avium subsp. paratuberculosis antigens. Microbes and Infection, 9, 963-970. Carlton, T. M., Sullivan, J. T., Stuart, G. S., Hutt, K., Lamont, I. L., & Ronson, C. W. (2007). Ferrichrome utilization in a mesorhizobial population: Microevolution of a three-locus system. Environmental Microbiology, 9(12), 2923-2932. Cox, R. A., & Cook, G. M. (2007). Growth regulation in the mycobacterial cell. Current Molecular Medicine, 7, 231-245. De Backer, E., Verhelst, R., Verstraelen, H., Al-Qumber, M., Burton, J. P., Tagg, J., Temmerman, M., & Vaneechoutte, M. (2007). Quantitative determination by real-time PCR of four vaginal Lactobacillus species, Gardnerella vaginalis and Atopobium vaginae indicates an inverse relationship between L. gasseri and L. iners. BMC Microbiology, 7(115). Dierksen, K. P., Moore, C. J., Inglis, M., Wescombe, P. A., & Tagg, J. R. (2007). The effect of ingestion of milk supplemented with salivaricin A-producing Streptococcus salivarius on the bacteriocin-like inhibitory activity of streptococcal populations on the tongue. FEMS Microbiology Ecology, 59, 584-591. Dillon, S., Sasagawa, T., Crawford, A., Prestidge, J., Inder, M. K., Jerram, J., Mercer, A. A., & Hibma, M. (2007). Resolution of cervical dysplasia is associated with T-cell proliferative responses to human papillomavirus type 16 E2. Journal of General Virology, 88, 803-813. Dorer, D. E., Czepluch, W., Lambeth, M. R., Dunn, A. C., Reitinger, C., Aldwell, F. E., & McLellan, A. D. (2007). Lymphatic tracing and T cell responses following oral vaccination with live Mycobacterium bovis (BCG). Cellular Microbiology, 9(2), 544-553. Dufour, M., Manson, J. M., Bremer, P. J., Dufour, J-P., Cook, G. M., & Simmonds, R. S. (2007). Characterization of monolaurin resistance in Enterococcus faecalis. Applied and Environmental Microbiology, 73(17), 5507-5515. Fineran, P. C., Williamson, N. R., Lilley, K. S., & Salmond, G. P. (2007). Virulence and prodigiosin antibiotic biosynthesis in Serratia are regulated pleiotropically by the GGDEF/EAL domain protein, PigX. Journal of Bacteriology, 189(21), 7653-7662. Fleming, S. B., Anderson, I. E., Thomson, J., Deane, D. L., McInnes, C. J., McCaughan, C. A., Mercer, A. A., & Haig, D. M. (2007). Infection with recombinant orf viruses demonstrates that the viral interleukin-10 is a virulence factor. Journal of General Virology, 88, 1922-1927. Gatehouse, H. S., Markwick, N. P., Poulton, J., Ward, V. K., Young, V., Wilson, S., Dellow, R., Sneddon, K., Gatehouse, L. N., Simpson, R. M., Janssen, B. J., Bishop, R., Schaffer, R. J., & Christeller, J. T. (2007). Effects of EppoNPV infection on gene expression in Epiphyas postvittana larvae. New Zealand Plant Protection, 60, 33-41. Harrow, S. A., Ravindran, V., Butler, R. C., Marshall, J. W., & Tannock, G. W. (2007). Real-time quantitative PCR measurement of Ileal Lactobacillus salivarius populations from broiler chickens to determine the influence of farming practices. Applied and Environmental Microbiology, 73(22), 7123-7127. Heng, N. C. K., Burtenshaw, G. A., Jack, R. W., & Tagg, J. R. (2007). Ubericin A, a class IIa bacteriocin produced by Streptococcus uberis. Applied and Environmental Microbiology, 73(23), 7763-7766. Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2007). Competence-dependent bacteriocin production by Streptococcus gordonii DL1 (Challis). Journal of Bacteriology, 189(4), 1468-1472. Hines, II, M. E., Stabel, J. R., Sweeney, R. W., Griffin, F., Talaat, A. M., Bakker, D., Benedictus, G., Davis, W., de Lisle, G. W., et al. (2007). Experimental challenge models for Johne’s disease: A review and proposed international guidelines. Veterinary Microbiology, 122, 197-222. Hubber, A. M., Sullivan, J. T., & Ronson, C. W. (2007). Symbiosis-induced cascade regulation of the Mesorhizobium loti R7A VirB/D4 type IV secretion system. Molecular Plant-Microbe Interactions, 20(3), 255-261.

Division of HEALTH SCIENCES 129 Hyink, O., Wescombe, P. A., Upton, M., Ragland, N., Burton, J. P., & Tagg, J. R. (2007). Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12. Applied and Environmental Microbiology, 73(4), 1107-1113. Hyun, J-K., Coulibaly, F., Turner, A. P., Baker, E. N., Mercer, A. A., & Mitra, A. K. (2007). The structure of a putative scaffolding protein of immature poxvirus particles as determined by electron microscopy suggests similarity with capsid proteins of large icosahedral DNA viruses. Journal of Virology, 81(20), 11075-11083. Inder, M. K., Ueda, N., Mercer, A. A., Fleming, S. B., & Wise, L. M. (2007). Bovine papular stomatitis virus encodes a functionally distinct VEGF that binds both VEGFR-1 and VEGFR-2. Journal of General Virology, 88, 781-791. Koch, N., McLellan, A. D., & Neumann, J. (2007). A revised model for invariant chain-mediated assembly of MHC class II peptide receptors. Trends in Biochemical Sciences, 32(12), 529-574. Lay, C., Dore, J., & Rigottier-Gois, L. (2007). Separation of bacteria of the Clostridium leptum subgroup from the human colonic microbiota by fluorescence-activated cell sorting or group-specific PCR using 16S rRNA gene oligonucleotides. FEMS Microbiology Ecology, 60, 513-520. Lee, S. M., Ender, M., Adhikari, R., Smith, J. M. B., Berger-Bächi, B., & Cook, G. M. (2007). Fitness cost of staphylococcal cassette chromosome mec in methicillin-resistant Staphylococcus aureus by way of continuous culture. Antimicrobial Agents and Chemotherapy, 51(4), 1497-1499. Maas, E. W., Latter, R. M., Thiele, J., Waite, A. M., & Brooks, H. J. L. (2007). Effect of multiple antibiotic treatments on a paralytic shellfish toxin-producing culture of the dinoflagellate Alexandrium minutum. Aquatic Microbial Ecology, 48, 255-260. Mackintosh, C. G., Labes, R. E., Clark, R. G., de Lisle, G. W., & Griffin, J. F. T. (2007). Experimental infections in young red deer (Cervus elaphus) with a bovine and an ovine strain of Mycobacterium avium subsp paratuberculosis. New Zealand Veterinary Journal, 55(1), 23-29. Mah, K. W., Chin, V. I. L., Wong, W. S., Lay, C., Tannock, G. W., Shek, L. P., Aw, M. M., Chua, K. Y., Wong, H. B., Panchalingham, A., & Lee, B. W. (2007). Effect of a milk formula containing probiotics on the fecal microbiota of Asian infants at risk of atopic diseases. Pediatric Research, 62(6), 674. McIntyre, H. J., Davies, H., Hore, T. A., Miller, S. H., Dufour, J-P., & Ronson, C. W. (2007). Trehalose biosynthesis in Rhizobium leguminosarum bv. trifolii and its role in desiccation tolerance. Applied and Environmental Microbiology, 73(12), 3984- 3992. McMillan, D. G. G., Keis, S., Dimroth, P., & Cook, G. M. (2007). A specific adaptation in the a subunit of thermoalkaliphilic F1Fo-ATP synthase enables ATP synthesis at high pH but not at neutral pH values. Journal of Biological Chemistry, 282(24), 17395-17404. McQueen, R. H., Laing, R. M., Brooks, H. J. L., & Niven, B. E. (2007). Odor intensity in apparel fabrics and the link with bacterial populations. Textile Research Journal, 77(7), 449-456. Meier, T., Morgner, N., Matthies, D., Pogoryelov, D., Keis, S., Cook, G. M., Dimroth, P., & Brutschy, B. (2007). A tridecameric c ring of the adenosine triphosphate (ATP) synthase from the thermoalkaliphilic Bacillus sp. strain TA2.A1 facilitates ATP synthesis at low electrochemical proton potential. Molecular Microbiology, 65(5), 1181-1192. Miller, S. H., Elliot, R. M., Sullivan, J. T., & Ronson, C. W. (2007). Host-specific regulation of symbiotic nitrogen fixation in Rhizobium leguminosarum biovar trifolii. Microbiology, 153, 3184-3195. Milligan, D. L., Tran, S. L., Strych, U., Cook, G. M., & Krause, K. L. (2007). The alanine racemase of Mycobacterium smegmatis is essential for growth in the absence of D-alanine. Journal of Bacteriology, 189(22), 8381-8386. O’Connor, E. B., Cotter, P. D., O’Connor, P., O’Sullivan, O., Tagg, J. R., Ross, R. P., & Hill, C. (2007). Relatedness between the two-component lantibiotics lacticin 3147 and staphylococcin C55 based on structure, genetics and biological activity. BMC Microbiology, 7(24). http://www.biomedcentral.com/content/pdf/1471-2180-7-24.pdf O’Donnell, J. L., Hayman, M. W., Spellerberg, M. B., McLellan, A. D., Brooksbank, K., Chapman, P. T., & Stamp, L. K. (2007). Antineutrophil cytoplasmic antibody measurement: Advantages and disadvantages of a capture PR3 ELISA and a direct PR3 ELISA. Pathology, 39(2), 258-263. Peacey, M., Wilson, S., Baird, M. A., & Ward, V. K. (2007). Versatile RHDV virus-like particles: Incorporation of antigens by genetic modification and chemical conjugation. Biotechnology and Bioengineering, 98(5), 968-977. Petty, N. K., Evans, T. J., Fineran, P. C., & Salmond, G. P. (2007). Biotechnological exploitation of bacteriophage research. Trends in Biotechnology, 25(1), 7-15. Pope, C. E., Wilson, J., Taboada, E. N., MacKinnon, J., Felipe Alves, C. A., Nash, J. H. E., Rahn, K., & Tannock, G. W. (2007). Epidemiology, relative invasive ability, molecular characterization, and competitive performance of Campylobacter jejuni strains in the chicken gut. Applied and Environmental Microbiology, 73(24), 7959-7966. Poulton, J., Markwick, N. P., Ward, V. K., & Young, V. (2007). Host range testing of a nucleopolyhedrovirus of the lightbrown apple moth, Epiphyas postvittana. New Zealand Plant Protection, 60, 26-32. Robson, C. L., Wescombe, P. A., Klesse, N. A., & Tagg, J. R. (2007). Isolation and partial characterization of the Streptococcus mutans type AII lantibiotic mutacin K8. Microbiology, 153, 1631-1641. Schwab, C., Walter, J., Tannock, G. W., Vogel, R. F., & Gänzle, M. G. (2007). Sucrose utilization and impact of sucrose on glycosyltransferase expression in Lactobacillus reuteri. Systematic and Applied Microbiology, 30, 433-443. Snell, A. E., Graves, S., Kane, R., Ward, V., Slaney, D., Mercer, A., Hearnden, M., & Weinstein, P. (2007). Pilot testing a genus wide PCR-based system for arbovirus detection in mosquitoes in New Zealand. The Weta, 33, 6-13.

130 RESEARCH REPORT 2007/2008 Stocker, A., Keis, S., Vonck, J., Cook, G. M., & Dimroth, P. (2007). The structural basis for unidirectional rotation of thermoalkaliphilic F1-ATPase. Structure, 15, 904-914. Swe, P. M., Heng, N. C. K., Ting, Y-T., Baird, H. J., Carne, A., Tauch, A., Tagg, J. R., & Jack, R. W. (2007). ef1097 and ypkK encode enterococcin V583 and corynicin JK, members of a new family of antimicrobial proteins (bacteriocins) with modular structure from Gram-positive bacteria. Microbiology, 153, 3218-3227. Ueda, N., Inder, M. K., Wise, L. M., Fleming, S. B., & Mercer, A. A. (2007). Parapoxvirus of red deer in New Zealand encodes a variant of viral vascular endothelial growth factor. Virus Research, 124, 50-58. Walter, J., Loach, D. M., Alqumber, M., Rockel, C., Hermann, C., Pfitzenmaier, M., & Tannock, G. W. (2007). D-Alanyl ester depletion of teichoic acids in Lactobacillus reuteri 100-23 results in impaired colonization of the mouse gastrointestinal tract. Environmental Microbiology, 9(7), 1750-1760. Ward, V. K., McCormick, C. J., Clarke, I. N., Salim, O., Wobus, C. E., Thackray, L. B., Virgin IV, H. W., & Lambden, P. R. (2007). Recovery of infectious murine norovirus using pol II-driven expression of full-length cDNA. PNAS, 104(26), 11050-11055. Westphal, D., Ledgerwood, E. C., Hibma, M. H., Fleming, S. B., Whelan, E. M., & Mercer, A. A. (2007). A novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus orf virus. Journal of Virology, 81(13), 7178-7188. Williamson, N. R., Fineran, P. C., Gristwood, T., Chawrai, S. R., Leeper, F. J., & Salmond, G. P. (2007). Anticancer and immunosuppressive properties of bacterial prodiginines. Future Microbiology, 2(6), 605-618. Wirawan, R. E., Swanson, K. M., Kleffmann, T., Jack, R. W., & Tagg, J. R. (2007). Uberlysin: A novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology, 153, 1619-1630. Wise, L., McCaughan, C., Tan, C. K., Mercer, A. A., & Fleming, S. B. (2007). Orf virus interleukin-10 inhibits cytokine synthesis in activated human THP-1 monocytes, but only partially impairs their proliferation. Journal of General Virology, 88, 1677-1682. Wise, L. M., Savory, L. J., Dryden, N. H., Whelan, E. M., Fleming, S. B., & Mercer, A. A. (2007). Major amino acid sequence variants of viral vascular endothelial growth factor are functionally equivalent during Orf virus infection of sheep skin. Virus Research, 128, 115-125. Yoon, S. S., Karabulut, A. C., Lipscomb, J. D., Hennigan, R., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., Gaston, B., Choi, K-H., Schweizer, H. P., & Hassett, D. J. (2007). Two-pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration. The EMBO Journal, 26(15), 3662-3672. Young, S. L., Slobbe, L., Wilson, R., Buddle, B. M., de Lisle, G. W., & Buchan, G. S. (2007). Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination. Infection and Immunity, 75(6), 2833-2840.

Journal – Research Other Leong, C-M., Hibma, M., & Tarbotton, J. (2007). Self-applied treatment of persistent plantar wart with 5% imiquimod cream. The New Zealand Medical Journal, 120(1259). http://www.nzma.org.nz/journal/120-1259/2668/ Tannock, G. W. (2007). What immunologists should know about bacterial communities of the human bowel. Seminars in Immunology, 19, 94-105.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY

Chapter in Book – Research Ashton, J. C. (2007). Oxidative stress induces upregulation of the CB2 receptor in a population of cells in the dentate gyrus subgranular layer. In S. G. Pandalai (Ed.), Recent Research Developments in Neuroscience (pp. 111-114). Kerala, India: Research Signpost. Ashton, J. C., & Smith, P. F. (2007). Bcl-2 and mitochondrial control of apoptosis as a mechanism for regulating neural plasticity. In L. B. Shultz (Ed.), Cell Apoptosis: Regulation and Environmental Factors (pp. 1-23). Nova Science. Clarkson, A. N., & Appleton, I. (2007). Cerebral hypoxia-ischemia-induced neuronal and cardiac impairment. In C. Kaur (Ed.), Hypoxia and the central nervous system (pp. 109-144). Kerala, India: Transworld Research Network. Smith, P. F., Zheng, Y., Goddard, M., & Darlington, C. L. (2007). Cognitive impairment due to inner ear damage. In H. C. Sentowski (Ed.), Cognitive Disorders Research Trends (pp. 231-243). New York: Nova Science.

Journal – Research Article Ashton, J. C. (2007). Cannabinoids for the treatment of inflammation. Current Opinion in Investigational Drugs, 8(5), 373-384. Ashton, J. C., & Glass, M. (2007). The cannabinoid CB2 receptor as a target for inflammation-dependent neurodegeneration. Current Neuropharmacology, 5(2), 73-80. Ashton, J. C., Rahman, R. M. A., Nair, S. M., Sutherland, B. A., Glass, M., & Appleton, I. (2007). Cerebral hypoxia-ischemia and middle cerebral artery occlusion induce expression of the cannabinoid CB2 receptor in the brain. Neuroscience Letters, 412(2), 114-117. Ashton, J. C., & Smith, P. F. (2007). Cannabinoids and cardiovascular disease: The outlook for clinical treatments. Current Vascular Pharmacology, 5, 173-174.

Division of HEALTH SCIENCES 131 Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561. Clarkson, A. N., Liu, H., Schiborra, F., Shaw, O., Sammut, I. A., Jackson, D. M., & Appleton, I. (2007). Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia. Brain Research, 1171, 111-121. Darlington, C. (2007). Drug evaluation: MBP-8298, a synthetic peptide analog of myelin basic protein for the treatment of multiple sclerosis. Current Opinion in Molecular Therapeutics, 9(4), 398-402. Darlington, C. L. (2007). The changing face of insulin receptors. Current Opinion in Investigational Drugs, 8(11), 885-886. Darlington, C. L., & Smith, P. F. (2007). Drug treatments for tinnitus. Progress in Brain Research, 166, 249-261. Elliott, M. S. J., Abuhamdah, S., Howes, M-J. R., Lees, G., Ballard, C. G., Holmes, C., Burns, A., Chazot, P. L., Perry, E. K., & Francis, P. T. (2007). The essential oils from Melissa officinalis L. and Lavandula angustifolia Mill. as potential treatment for agitation in people with severe dementia. International Journal of Essential Oil Therapeutics, 1(4), 143-152. Foronda, N. M., Fowles, J., Smith, N. A., Taylor, M., Temple, W., & Darlington, C. (2007). The use of myocardial and testicular end points as a basis for estimating a proposed tolerable daily intake for sodium mono fluoro acetete (1080). Regulatory Toxicology and Pharmacology, 47(1), 29-36. Hesp, B. R., Clarkson, A. N., Sawant, P. M., & Kerr, D. S. (2007). Domoic acid preconditioning and seizure induction in young and aged rats. Epilepsy Research, 76, 103-112. Payne, H. L., Connelly, W. M., Ives, J. H., Lehner, R., Furtmuller, B., Sieghart, W., Tiwari, P., Lucocq, J. M., Lees, G., & Thompson, C. L. (2007). GABAA alpha 6-containing receptors are selectively compromised in cerebellar granule cells of the ataxic mouse, stargazer. Journal of Biological Chemistry, 282(40), 29130-29143. Sawant, P. M., Weare, B. A., Holland, P. T., Selwood, A. I., King, K. L., Mikulski, C. M., Doucette, G. J., Mountfort, D. O., & Kerr, D. S. (2007). Isodomoic acids A and C exhibit low KA receptor affinity and reduced in vitro potency relative to domoic acid in region CAI of rat hippocampus. Toxicon, 50(5), 627-638. Smith, P. F. (2007). Symptomatic treatment of multiple sclerosis using cannabinoids: Recent advances. Expert Review of Neurotherapeutics, 7(9), 1157-1163. Smith, P. F. (2007). Will medicinal cannabinoids prove to be useful clinically? Current Drug Therapy, 2(2), 143-150. Stuart, E. C., Larsen, L., & Rosengren, R. J. (2007). Potential mechanisms for the synergistic cytotoxicity elicited by 4-hydroxytamoxifen and epigallocatechin gallate in MDA-MB-231 cells. International Journal of Oncology, 30(6), 1407-1412. Zheng, Y., Baek, J-h., Smith, P. F., & Darlington, C. L. (2007). Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. Hearing Research, 228, 105-111. Zheng, Y., Goddard, M., Darlington, C. L., & Smith, P. F. (2007). Bilateral vestibular deafferentation impairs performance in a spatial forced alternation task in rats. Hippocampus, 17, 253-256. Zheng, Y., Hooton, K., Smith, P. F., & Darlington, C. L. (2007). Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatments in rats. Acta Oto-Laryngologica, 128(1), 48-52.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF PHYSIOLOGY

Chapter in Book – Research Blumgart, L. H., Wheatley, A. M., & Mathie, R. T. (2007). Liver blood flow: Physiology measurement, and clinical relevance. In L. H. Blumgart (Ed.), Surgery of the liver, biliary tract, and pancreas (4 ed.). (pp. 37-53). Philadelphia: Elsevier. Wintermantel, T. M., Elzer, J., Herbison, A. E., Fritzemeier, K. -H., & Schütz, G. (2007). Genetic dissection of estrogen receptor signaling in vivo. In K.S. Korach, & T. Wintermantel (Eds), Tissue-specific estrogen action: Novel mechanisms, novel ligands, novel therapies (pp. 25-44). Berlin, Russia: Springer.

Journal – Research Article Ainslie, P., Burgess, K., Subedi, P., & Burgess, K. R. (2007). Alterations in cerebral dynamics at high altitude following partial acclimatization in humans: Wakefulness and sleep. Journal of Applied Physiology, 102, 658-664. Ainslie, P. N., Barach, A., Cummings, K. J., Murrell, C., Hamlin, M., & Hellemans, J. (2007). Cardiorespiratory and cerebrovascular responses to acute poikilocapnic hypoxia following intermittent and continuous exposure to hypoxia in humans. Journal Applied Physiology, 102, 1953-1961. Ainslie, P. N., Barach, A., Murrell, C., Hamlin, M., Hellemans, J., & Ogoh, S. (2007). Alterations in cerebral autoregulation and cerebral blood flow velocity during acute hypoxia: Rest and exercise. American Journal of Physiology – Heart and Circulatory Physiology, 292, H976-H983. Ainslie, P. N., Murrell, C., Peebles, K., Swart, M., Skinner, M. A., Williams, M. J. A., & Taylor, R. D. (2007). Early morning impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: Relation to endothelial function. Experimental Physiology, 92(4), 769-777. Baddock, S. A., Galland, B. C., Taylor, B. J., & Bolton, D. P. (2007). Sleep arrangements and behavior of bed-sharing families in the home setting. Pediatrics, 119, 200-207. Bartolo, R. C., & Donald, J. A. (2007). The distribution of renal hyaluronan and the expression of hyaluronan synthases during water deprivation in the Spinifex hopping mouse, Notomys alexis. Comparative Biochemistry and Physiology, 148, 853-860.

132 RESEARCH REPORT 2007/2008 Bedford, J. J., & Leader, J. P. (2007). Organic osmolytes in the developing kidney of the Australian brush-tailed possum, Trichosurus vulpecula. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology, 147, 1047- 1052. Boyd, J., Buick, J. M., & Green, S. (2007). Analysis of the Casson and Carreau-Yasuda non-Newtonian blood models in steady and oscillatory flows using the lattice Boltzmann method. Physics of Fluids, 19. Brickley, G., Green, S., Jenkins, D. G., McEinery, M., Wishart, C., Doust, J. D., & Williams, C. A. (2007). Muscle metabolism during constant- and alternating-intensity exercise around critical power. International Journal of Sports Medicine, 28(4), 300-305. Brown, C. H., & Grattan, D. R. (2007). Does maternal oxytocin protect the fetal brain? Trends in Endocrinology and Metabolism, 18(6), 225-226. Brown, C. H., Scott, V., Ludwig, M., Leng, G., & Bourque, C. W. (2007). Somatodendritic dynorphin release: Orchestrating activity patterns of vasopressin neurons. Biochemical Society Transactions, 35(5), 1236-1242. Button, C., Anderson, N., Bradford, C., Cotter, J. D., & Ainslie, P. N. (2007). The effect of multidirectional mechanical vibration on peripheral circulation of humans. Clinical Physiology and Functional Imaging, 27, 211-216. Campbell, R. E. (2007). Defining the gonadotrophin-releasing hormone neuronal network: Transgenic approaches to understanding neurocircuitry. Journal of Neuroendocrinology, 19, 561-573. Campbell, R. E., & Herbison, A. E. (2007). Definition of brainstem afferents to gonadotropin-releasing hormone neurons in the mouse using conditional viral tract tracing. Endocrinology, 148(12), 5884-5890. Clarkson, A. N., Clarkson, J., Jackson, D. M., & Sammut, I. A. (2007). Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration. Neuroscience, 144, 547-561. Coddington, E., Lewis, C., Rose, J. D., & Moore, F. L. (2007). Endocannabinoids mediate the effects of acute stress and corticosterone on sex behavior. Endocrinology, 148(2), 493-500. Cummings, K. J., Swart, M., & Ainslie, P. (2007). Morning attenuation in cerebrovascular CO2 reactivity in healthy humans is associated with a lowered cerebral oxygenation and an augmented ventilatory response to CO2. Journal Applied Physiology, 102, 1891-1898. Ducret, E., Le Feuvre, Y., Meyrand, P., & Fénelon, V. S. (2007). Removal of GABA within adult modulatory systems alters electrical coupling and allows expression of an embryonic-like network. Journal of Neuroscience, 27(14), 3626-3638. Egaña, M., & Green, S. (2007). Intensity-dependent effect of body tilt angle on calf muscle fatigue in humans. European Journal of Applied Physiology, 99, 1-9. Egaña, M., Smith, S., & Green, S. (2007). Revisiting the effect of posture on high-intensity constant-load cycling performance in men and women. European Journal of Applied Physiology, 99, 495-501. Empson, R. M., Garside, M. L., & Knöpfel, T. (2007). Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse. Journal of Neuroscience, 27(14), 3753-3758. Grattan, D. R., Jasoni, C. L., Liu, X., Anderson, G. M., & Herbison, A. E. (2007). Prolactin regulation of gonadotropin-releasing hormone neurons to suppress luteinizing hormone secretion in mice. Endocrinology, 148(9), 4344-4351. Green, S., Askew, C. D., & Walker, P. J. (2007). Effect of type 2 diabetes mellitus on exercise intolerance and the physiological responses to exercise in peripheral arterial disease. Diabetologia, 50, 859-866. Herbison, A. E. (2007). Genetics of puberty. Hormone Research, 68(Suppl. 5), 75-79. Highton, J., Hung, N., Hessian, P., & Wilsher, M. (2007). Pulmonary rheumatoid nodules demonstrating features usually associated with rheumatoid synovial membrane. Rheumatology, 46, 811-814. Jasoni, C. L., Todman, M. G., Strumia, M. M., & Herbison, A. E. (2007). Cell type-specific expression of a genetically encoded calcium indicator reveals intrinsic calcium oscillations in adult gonadotropin-releasing hormone neurons. Journal of Neuroscience, 27(4), 860-867. Jensen, T. P., Filoteo, A. G., Knopfel, T., & Empson, R. M. (2007). Presynaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3. Journal of Physiology, 579, 85-99. Jones, H. M., Bailey, M. A., Baty, C. J., MacGregor, G. G., Syme, C. A., Hamilton, K. L., & Devor, D. C. (2007). An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1. Channels, 1(2), 80-91. Li, C., Stanton, J-A. L., Robertson, T. M., Suttie, J. M., Sheard, P. W., Harris, A. J., & Clark, D. E. (2007). Nerve growth factor mRNA expression in the regenerating antler tip of red deer (Cervus elaphus). PLoS ONE, 2(1). http://www.plosone.org/ article/info%3Adoi%2F10.1371%2Fjournal.pone.0000148 Lowrey, S., De Silva, L., Hodgkinson, I., & Leader, J. (2007). Observation and modeling of polarized light from scarab beetles. Journal of the Optical Society of America A, 24(8), 2418-2425. McLaughlin, C. W., Zellhuber-McMillan, S., Macknight, A. D. C., & Civan, M. M. (2007). Electron microprobe analysis of rabbit ciliary epithelium indicates enhanced secretion posteriorly and enhanced absorption anteriorly. American Journal of Physiology - Cell Physiology, 293: C1455-C1466. Murrell, C., Wilson, L., Cotter, J. D., Lucas, S., Ogoh, S., George, K., & Ainslie, P. (2007). Alterations in autonomic function and cerebral hemodynamics to orthostatic challenge following a mountain marathon. Journal of Applied Physiology, 103, 88-96. Nagao, T., Matsumura, M., Mabuchi, A., Ishida-Okawara, A., Koshio, O., Nakayama, T., Minamitani, H., & Suzuki, K. (2007). Up-regulation of adhesion molecule expression in glomerular endothelial cells by anti-myeloperoxidase antibody. Nephrology Dialysis Transplantation, 22(1), 77-87.

Division of HEALTH SCIENCES 133 Papp, A. M., Nyilas, R., Szepesi, Z., Lörincz, M., Takács, E., Ábrahám, I., Szilágyi, N., Tóth, J., Medveczky, P., Szilágyi, L., Juhász, G., & Juhász, G. (2007). Visible light induces matrix metalloproteinase-9 expression in rat eye. Journal of Neurochemistry, 103, 2224-2233. Parr-Brownlie, L. C., Poloskey, S. L., Flanagan, K. K., Eisenhofer, G., Bergstrom, D. A., & Walters, J. R. (2007). Dopamine lesion-induced changes in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats. European Journal of Neuroscience, 26, 1925-1939. Peebles, K., Celi, L., McGrattan, K., Murrell, C., Thomas, K., & Ainslie, P. N. (2007). Human cerebrovascular and ventilatory CO2 reactivity to end-tidal, arterial and internal jugular vein PCO2. Journal of Physiology, 584(1), 347-357. Qu, L., Liu, X., Wu, C., & Leung, L. S. (2007). Hyperthermia decreases GABAergic synaptic transmission in hippocampal neurons of immature rats. Neurobiology of Disease, 27, 320-327. Schultz, M., & Butt, A. G. (2007). Methodological aspects in probiotic research: A brief review with an emphasis on epithelial barrier function. International Journal of Probiotics and Prebiotics, 2(2/3), 85-96. Schwenke, D. O., Bolter, C. P., & Cragg, P. A. (2007). Are the carotid bodies of the guinea-pig functional? Comparative Biochemistry and Physiology, 146(2), 180-188. Scoon, G. S. M., Hopkins, W. G., Mayhew, S., & Cotter, J. D. (2007). Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. Journal of Science and Medicine in Sport, 10, 259-262. Scott, V., McDade, D. M., & Luckman, S. M. (2007). Rapid changes in the sensitivity of arcuate nucleus neurons to central ghrelin in relation to feeding status. Physiology & Behaviour, 90, 180-185. Sturm, A., Gorboulev, V., Gorbunov, D., Keller, T., Volk, C., Schmitt, B. M., Schlachtbauer, P., Ciarimboli, G., & Koepsell, H. (2007). Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity. American Journal of Physiology Renal Physiology, 293, F767-F779. Sullivan, J. M., Faumont, S., Ducret, E., Le Feuvre, Y., Fénelon, V. S., & Meyrand, P. (2007). Long-term exposure to histamine induces the expression of an embryonic-like motor pattern in an adult nervous system. European Journal of Neuroscience, 26(11), 3181-3192. Walters, J. R., Hu, D., Itoga, C. A., Parr-Brownlie, L. C., & Bergstrom, D. A. (2007). Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine. Neuroscience, 144, 762-776. Wen, J. Y., McLeod, B. J., Tucker, I. G., Davies, N. M., Ledger, R., & Butt, A. G. (2007). Enhancing absorption of fluorescein and LHRH across hindgut epithelia in a marsupial, the common brushtail possum Trichosurus vulpecula. Journal of Pharmaceutical Sciences, 96(9), 2262-2273. Wiemuth, D., Ke, Y., Rohlfs, M., & McDonald, F. J. (2007). Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface. Biochemical Journal, 405, 147-155. Wu, Y-N., Hyland, B. I., & Chen, J-J. (2007). Biomechanical and electromyogram characterization of neuroleptic-induced rigidity in the rat. Neuroscience, 147, 183-196.

Journal – Research Other Highton, J., Hessian, P. A., & Stamp, L. K. (2007). The Rheumatoid nodule: Peripheral or central to rheumatoid arthritis? [Editorial]. Rheumatology, 46, 1385-1387. Wickens, J. R., Budd, C. S., Hyland, B. I., & Arbuthnott, G. W. (2007). Striatal contributions to reward and decision making: Making sense of regional variations in a reiterated processing matrix. Annals of the New York Academy of Sciences, 1104, 192-212.

DUNEDIN SCHOOL OF MEDICINE DEAN’S DEPARTMENT

Chapter in Book – Textbook & Other MacLeod, R., & Egan, T. (2007). Interprofessional education. In B. Wee & N. Hughes (Eds.), Education in palliative care: Building a culture of learning (pp. 235-249). Oxford University Press.

Journal – Research Article Bradford, C. D., Cotter, J. D., Thorburn, M. S., Walker, R. J., & Gerrard, D. F. (2007). Exercise can be pyrogenic in humans. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 292, R143-R149. Helge, J. W., Rehrer, N. J., Pilegaard, H., Manning, P., Lucas, S. E., Gerrard, D. F., & Cotter, J. D. (2007). Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise. Acta Physiologica, 191, 77-86. McKechnie, R., MacLeod, R., & Keeling, S. (2007). Facing uncertainty: The lived experience of palliative care. Palliative and Supportive Care, 5, 255-264. Wilson, C., Kerruish, N. J., Wilcken, B., Wiltshire, E., & Webster, D. (2007). The failure to diagnose inborn errors of metabolism in New Zealand: The case for expanded newborn screening. The New Zealand Medical Journal, 120(1262). http://www.nzma.org.nz/journal/120-1262/2727/

Journal – Research Other Gerrard, D. (2007). [Commentary]. British Journal of Sports Medicine, 41, 698.

134 RESEARCH REPORT 2007/2008 DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF GENERAL PRACTICE

Chapter in Book – Textbook & Other MacLeod, R., & Egan, T. (2007). Interprofessional education. In B. Wee & N. Hughes (Eds.), Education in palliative care: Building a culture of learning (pp. 235-249). Oxford University Press.

Journal – Research Article Mann, B. S., & Jaye, C. (2007). ‘Are we one body?’ Body boundaries in telesomatic experiences. Anthropology & Medicine, 14(2), 183-195. McClenaghan, T., Dovey, S., Tilyard, M., & Tomlin, A. (2007). Checking ‘Get Checked’. New Zealand Family Physician, 34(3), 177-182. McKechnie, R., MacLeod, R., & Keeling, S. (2007). Facing uncertainty: The lived experience of palliative care. Palliative and Supportive Care, 5, 255-264. Miller, D., & Jaye, C. (2007). GPs’ perception of their role in the identification and management of family violence. Family Practice, 24(2), 95-101. Reid, J. (2007). Fees in primary care. The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/ journal/120-1254/2530/ Tomlin, A., Dovey, S., & Tilyard, M. (2007). Health outcomes for diabetes patients returning for three annual general practice checks. The New Zealand Medical Journal, 120(1252). http://www.nzma.org.nz/journal/120-1252/2493/ Wyber, R., & Egan, T. (2007). For better or worse: Role models for New Zealand house officers. The New Zealand Medical Journal, 120(1253). http://www.nzma.org.nz/journal/120-1253/2518/

Journal – Research Other Dovey, S. (2007). Leaping off laurels: Time for a paradigm change to promote patient safety. New Zealand Family Physician, 34(1), 10-11.

Journal – Professional & Other Non-Research Articles Nixon, G. (2007). Medical emergencies in rural practice. New Zealand Family Physician, 34(6), 419-421. Nixon, G., Blattner, K., for the NZ Rural Hospital Doctors Working Party (2007). Rural hospital medicine in New Zealand: Vocational registration and the recognition of a new scope of practice [Special article]. The New Zealand Medical Journal, 120(1259). http://www.nzma.org.nz/journal/120-1259/2654/ Reid, J. (2007). The integration of managed healthcare in New Zealand [Editorial]. The New Zealand Medical Journal, 120(1252). http://www.nzma.org.nz/journal/120-1252/2488/ Reid, J. J. (2007). Chronic obstructive pulmonary disease. New Zealand Doctor, (April), 23-28. Storr, E. F., de Vere Beavis, F. O., & Stringer, M. D. (2007). Texting tenosynovitis [Case notes]. The New Zealand Medical Journal, 120(1267). http://www.nzma.org.nz/journal/120-1267/2868/

DUNEDIN SCHOOL OF MEDICINE ANAESTHESIA AND INTENSIVE CARE SECTION

Journal – Research Article Conlon, N. P., Sullivan, R. P., Herbison, P. G., Zacharias, M., & Buggy, D. J. (2007). The effect of leaving dentures in place on bag-mask ventilation at induction of general anesthesia. Ambulatory Anesthesiology, 105(2), 370-373. McLennan, S., Celi, L. A., & Roth, P. (2007). The Health and Safety in Employment Act and the influenza vaccination of healthcare workers. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2442/ content.pdf Peebles, K., Celi, L., McGrattan, K., Murrell, C., Thomas, K., & Ainslie, P. N. (2007). Human cerebrovascular and ventilatory

CO2 reactivity to end-tidal, arterial and internal jugular vein P-CO2. The Journal of Physiology, 584(1), 347-357.

Journal – Professional & Other Non-Research Articles Yap, J., & Celi, L. A. (2007). Elderly access to medical care: Should age be a factor in deciding management? [Editorial]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2838/

Division of HEALTH SCIENCES 135 DUNEDIN SCHOOL OF MEDICINE BIOETHICS CENTRE

Chapter in Book – Research Evans, D. M. (2007). Ethics, nanotechnology and health. In A.M.J. Henk & Have ten (Eds.), Nanotechnologies, Ethics and Politics (pp. 125-153). Paris, France: United Nations Educational. Gillett, G. (2007). Psychosurgery and neuroimplantation: Changing what is deep within a person. In R.E. Ashcroft, A. Dawson, H. Draper, & J.R. McMillan (Eds.), Principles of Health Care Ethics (2nd ed.). (pp. 811-817). Chichester, West Sussex, England: John Wiley & Sons. Gillett, G. (2007). The paralogisms of psychosis. In M. C. Cheung, K. W. M. (Bill), Fulford & G. Graham (Eds.), Reconceiving Schizophrenia (pp. 151-165). New York: Oxford University Press. King, M. (2007). The Advisory Committee on Assisted Reproductive Technologies: The role of public consultation in decision- making. In N. Page (Ed.), Genes, society and the future (Vol. 1) (pp. 147-195). Dunedin, New Zealand: Human Genome Research Project, University of Otago. Nie, J-B. (2007). The specious idea of an Asian bioethics: Beyond dichotomizing East and West. In R. E. Ashcroft, A. Dawson, H. Draper & J.R. McMillan (Eds.), Principles of Health Care Ethics (2nd ed.). (pp. 143-149). Chichester, West Sussex, England: John Wiley & Sons. Wensley, D. (2007). Researching human genetic variation: An examination of the ethics of genetic research. In N. Page (Ed.), Genes, society and the future (Vol.1) (pp. 331-378). Dunedin, New Zealand: Human Genome Research Project, University of Otago.

Journal – Research Article Anderson, L. (2007). Doctoring risk: Responding to risk-taking in athletes. Sport, Ethics and Philosophy, 1(2), 119-134. Cohen, C. B., Enzle, M. E., Dickens, B., Brandhorst, B., Clark, T., Clute, C., Dunstan, D., Evans, D., Lambert, R. D., Langlois, S., Leader, A., & Robertson, C. M. G. (2007). Oversight of stem cell research in Canada: Protecting the rights, health, and safety of embryo donors. Health Law Review, 16(2), 86-102. Gillett, G. (2007). Subjectivity, voice and narratives in clinical medicine. Junctures, 9, 15-25. Gillett, G. (2007). The use of human tissue. Bioethical Inquiry, 4(2), 119-127. Gillett, G., & Chisholm, N. (2007). Locked in syndrome, PVS and ethics at the end of life. Journal of Ethics in Mental Health, 2(2). Gillett, G. R., & McKergow, F. (2007). Genes, ownership, indigenous reality. Social Science & Medicine, 65, 2093-2104. King, M. R., Wester, T. J., & Morel, P. C. H. (2007). The effect of dietary spray-dried bovine colostrum and plasma on the response of pigs to enterotoxigenic E. coli challenge after weaning. Livestock Science, 108, 292-294. McLennan, S., Celi, L. A., & Roth, P. (2007). The Health and Safety in Employment Act and the influenza vaccination of healthcare workers. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2442/ content.pdf Nie, J-B., & Campbell, A. V. (2007). Multiculturalism and Asian bioethics: Cultural war or creative dialogue? Bioethical Inquiry, 4(3), 163-167. Wallis, K. (2007). Cervical screening legislation is unethical and has the potential to be counter-productive. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2840/

Edited Journal Donchin, A., Dodds, S., & Nie, J-B. (Eds.). (2007). Bioethics, 21(9).

DUNEDIN SCHOOL OF MEDICINE MEDICINE SECTION

Edited Book – Research Mann, J., & Truswell, A. S. (Eds.). (2007). Essentials of human nutrition (3rd ed.). Oxford University Press, 599p.

Chapter in Book – Research Cummings, J., & Mann, J. I. (2007). Carbohydrates. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition (3rd ed.). (pp. 8-32). Oxford: Oxford University Press. Goulding, A. (2007). Major minerals: Calcium and magnesium. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition (3rd ed.). (pp. 112-124). Oxford University Press. Goulding, A. (2007). Risk factors for fractures in normally active children and adolescents. In R. M. Daly & M. A. Petit (Eds.), Optimizing bone mass and strength (pp. 102-120). New York: Basel. Goulding, A., & Grant, A. (2007). Nutritional strategies to optimize bone health throughout the life course. In S. Lanham- New, T. O’Neill, R. Morris, D. Skelton, & A. Sutcliffe (Eds.), Managing osteoporosis (pp. 3-19). Oxford, UK: Atlas Medical. Mann, J. (2007). Diabetes mellitus and the metabolic syndrome. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition (3rd ed.). (pp. 327-342). Oxford University Press.

136 RESEARCH REPORT 2007/2008 Mann, J., & Chisholm, A. (2007). Cardiovascular diseases. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition (3rd ed.). (pp. 282-312). Oxford: Oxford University Press. Mann, J. I., & Skeaff, M. (2007). Lipids. In J. Mann & A. S. Truswell (Eds.), Essentials of human nutrition (3rd ed.). (pp. 33-52). Oxford: Oxford University Press. Robertson, M. C., & Campbell, A. J. (2007). What type of exercise reduces falls in older people? In D. MacAuley & T. M Best (Eds.), Evidence-based sports medicine (2nd ed.). (pp. 135-166). Blackwell.

Journal – Research Article Ainslie, P. N., Murrell, C., Peebles, K., Swart, M., Skinner, M. A., Williams, M. J. A., & Taylor, R. D. (2007). Early morning impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: Relation to endothelial function. Experimental Physiology, 92(4), 769-777. Bradford, C. D., Cotter, J. D., Thorburn, M. S., Walker, R. J., & Gerrard, D. F. (2007). Exercise can be pyrogenic in humans. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 292, R143-R149. Campbell, A. J., & Robertson, M. C. (2007). Rethinking individual and community fall prevention strategies: A meta- regression comparing single and multifactorial interventions. Age and Ageing, 36, 656-662. Clark-Grill, M. (2007). Questionable gate-keeping: Scientific evidence for complementary and alternative medicines (CAM): Response to Malcolm Parker. Bioethical Inquiry, 4, 21-28. Connor, A., Stebbings, S. M., Hung, N. A., Hammond-Tooke, G., Meikle, G., & Highton, J. (2007). STIR MRI to direct muscle biopsy in suspected idiopathic inflammatory myopathy. Journal of Clinical Rheumatology, 13(6), 341-345. Elley, C. R., Robertson, M. C., Kerse, N. M., Garrett, S., McKinlay, E., Lawton, B., Moriarty, H., & Campbell, A. J. (2007). Falls Assessment Clinical Trial (FACT): Design, interventions, recruitment strategies and participant characteristics. BMC Public Health, 7. http://www.biomedcentral.com/1471-2458/7/185 Goulding, A. (2007). Childhood fractures: Time to implement strategies to reduce these events. International Congress Series, 1297, 3-14. Goulding, A., Grant, A. M., Taylor, R. W., Williams, S. M., Parnell, W. R., Wilson, N., & Mann, J. (2007). Ethnic differences in extreme obesity. Journal of Pediatrics, 151, 542-544. Hammond-Tooke, G. D., Taylor, P., Punchihewa, S., & Beasley, M. (2007). Urtica ferox neuropathy. Muscle and Nerve, 35, 804-807. Hancox, R. J., Poulton, R., Greene, J. M., Filsell, S., McLachlan, C. R., Rasmussen, F., Taylor, D. R., Williams, M. J. A., Williamson, A., & Sears, M. R. (2007). Systemic inflammation and lung function in young adults. Thorax, 62, 1064-1068. Hanger, H. C., Wilkinson, T. J., Fayez-Iskander, N., & Sainsbury, R. (2007). The risk of recurrent stroke after intracerebral haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, 78, 836-840. Hayman, K. J., Kerse, N. M., La Grow, S. J., Wouldes, T., Robertson, M. C., & Campbell, A. J. (2007). Depression in older people: Visual impairment and subjective ratings of health. Optometry and Vision Science, 84(11), 1024-1030. Helge, J. W., Rehrer, N. J., Pilegaard, H., Manning, P., Lucas, S. E., Gerrard, D. F., & Cotter, J. D. (2007). Increased fat oxidation and regulation of metabolic genes with ultraendurance exercise. Acta Physiologica, 191, 77-86. Highton, J., Hung, N., Hessian, P., & Wilsher, M. (2007). Pulmonary rheumatoid nodules demonstrating features usually associated with rheumatoid synovial membrane. Rheumatology, 46, 811-814. Hill, G., Albayati, S., Thomson, I., Macfarlane, J., Dutton, S., & van Rij, A. M. (2007). Iatrogenic pseudoaneurysms: Optimal management and treatment options. Journal for Vascular Ultrasound, 31(3), 131-135. Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685. Kerr, P. G., Sutherland, W. H. F., de Jong, S., Vaithalingham, I., Williams, S. M., & Walker, R. J. (2007). The impact of standard high-flux polysulfone versus novel high-flux polysulfone dialysis membranes on inflammatory markers: A randomized, single-blinded, controlled clinical trial. American Journal of Kidney Diseases, 49(4), 533-539. Knight, J. G., Menkes, D. B., Highton, J., & Adams, D. D. (2007). Rationale for a trial of immunosuppressive therapy in acute schizophrenia. Molecular Psychiatry, 12(5), 424-431. Limaye, V., Blumbergs, P., Scott, G., Hakendorf, P., Stevanovic, V., Highton, J., & Roberts-Thomson, P. (2007). The epidemiology of dermatomyositis in South Australia. APLAR Journal of Rheumatology, 10, 94-100. Mann, J. (2007). Dietary carbohydrate: Relationship to cardiovascular disease and disorders of carbohydrate metabolism. European Journal of Clinical Nutrition, 61(Suppl. 1), S100-S111. Mann, J., Cummings, J. H., Englyst, H. N., Key, T. J. A., Liu, S., Riccardi, G., Summerbell, C., Uauy, R., van Dam, R. M., Venn, B. J., Vorster, H. H., & Wise, M. (2007). FAO/WHO scientific update on carbohydrates in human nutrition: Conclusions. European Journal of Clinical Nutrition, 61(Suppl.1), S132-S137. Mann, J., & McAuley, K. (2007). Carbohydrates: Is the advice to eat less justified for diabetes and cardiovascular health? Current Opinion in Lipidology, 18, 9-12. McAuley, K. A., Mann, J. I., Chase, J. G., Lotz, T. F., & Shaw, G. M. (2007). HOMA: The best bet for the simple determination of insulin sensitivity, until something better comes along. Diabetes Care, 30(9), 2411-2413. McLachlan, C. R., Poulton, R., Car, G., Cowan, J., Filsell, S., Greene, J., Taylor, D. R., Welch, D., Williamson, A., Sears, M. R., & Hancox, R. J. (2007). Adiposity, asthma, and airway inflammation. Journal of Allergy and Clinical Immunology, 119(3), 634-639. Miller, J. C., Grant, A. M., Drummond, B. F., Williams, S. M., Taylor, R. W., & Goulding, A. (2007). DXA measurements confirm that parental perceptions of elevated adiposity in young children are poor. Obesity, 15(1), 165-171.

Division of HEALTH SCIENCES 137 Schultz, M., & Butt, A. G. (2007). Methodological aspects in probiotic research: A brief review with an emphais on epithelial barrier function. International Journal of Probiotics and Prebiotics, 2(2/3), 85-96. Steer, S., Abkevich, V., Gutin, A., Cordell, H. J., Gendall, K. L., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J., Stamp, L., Fitzgerald, L., Iliev, D., Kouzmine, A., Tran, T., Skolnick, M. H., Timms, K. M., Lanchbury, J. S., & Merriman, T. R. (2007). Genomic DNA pooling for whole-genome association scans in complex disease: Empirical demonstration of efficacy in rheumatoid arthritis. Genes and Immunity, 8, 57-68. Sutherland, T. J. T., Taylor, D. R., Sears, M. R., Cowan, J. O., McLachlan, C. R., Filsell, S., Williamson, A., Greene, J. M., Poulton, R., & Hancox, R. J. (2007). Association between exhaled nitric oxide and systemic inflammatory markers. Annals of Allergy, Asthma & Immunology, 99(4), 334-339. Sutherland, W. H. F., de Jong, S. A., & Walker, R. J. (2007). Effect of dietary cholesterol and fat on cell cholesterol transfer to postprandial plasma in hyperlipidemic men. Lipids, 42, 901-911. Sutherland, W. H. F., Manning, P. J., Walker, R. J., Jong, S. A. D., Ryalls, A. R., & Berry, E. A. (2007). Vitamin E supplementation and plasma 8-isoprostane and adiponectin in overweight subjects. Obesity, 15(2), 386-391. Sutherland, W. H. F., Williams, M. J. A., de Jong, S. A., & McCormick, M. P. (2007). Ingestion of moderately thermally oxidized polyunsaturated fat decreases serum resistance to oxidation in men with coronary artery disease. Nutrition Research, 27, 265-272. Sutherland, W. H., Williams, M. J., & de Jong, S. A. (2007). Plasma protein lipofuscin-like fluorophores in men with coronary artery disease treated with statins. Archives of Medical Research, 38, 757-763. Tang, E. W., Wong, C-K., & Herbison, P. (2007). Global registry of acute coronary events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. American Heart Journal, 153, 29-35. Taylor, D. R. (2007). Beta-adrenergic receptor polymorphisms: Relationship to the beta-agonist controversy and clinical implications. Expert opinion on pharmacotherapy, 8(18), 3195-3203. Taylor, D. R., Mandhane, P., Greene, J. M., Hancox, R. J., Filsell, S., McLachlan, C. R., Williamson, A. J., Cowan, J. O., Smith, A. D., & Sears, M. R. (2007). Factors affecting exhaled nitric oxide measurements: The effect of sex. Respiratory Research, 8. http://respiratory-research.com/content/8/1/82 Taylor, R. W., McAuley, K. A., Barbezat, W., Strong, A., Williams, S. M., & Mann, J. I. (2007). APPLE project: 2-y findings of a community-based obesity prevention program in primary school-age children. American Journal of Clinical Nutrition, 86, 735-742. Tie, S., Wong, C-K., Yap, J., Wilkins, G., Williams, M., & Kay, P. (2007). Timing of thrombotic events in patients receiving 2 weeks of clopidogrel therapy post bare metal coronary artery stenting: A New Zealand retrospective study. The New Zealand Medical Journal, 120(1255). http://www.nzma.org.nz/journal/120-1255/2553/ Wilson, J. C., Yoon, H-S., Walker, R. J., & Eccles, R. R. (2007). A novel Cys1638Tyr NC1 domain substitution in 〈5(IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities. Nephrology Dialysis Transplantation, 22(5), 1338-1346. Wong, C-K., Kleiman, N. S., & White, H. D. (2007). Beyond pharmacology in heart attacks: Coronary stents and stem cells. Heart and Metabolism, 36, 19-23. Wong, C-K., Newby, L. K., Bhapker, M. V., Aylward, P. E., Pfisterer, M., Alexander, K. P., Armstrong, P. W., et al. (2007). Use of evidence-based medicine for acute coronary syndromes in the elderly and very elderly: Insights from the Sibrafiban vs aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes trials. American Heart Journal, 154, 313-321. Wong, C-K., Tang, E. W., & Herbison, P. (2007). Survival over 5 years in the initial hospital surviviors with acute coronary syndrome: A comparison between a community hospital and a tertiary hospital in New Zealand. The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/journal/120-1261/2713/ Wong, C-K., & White, H. D. (2007). Direct antithrombins: Mechanisms, trials, and role in contemporary interventional medicine. American Journal of Cardiovascular Drugs, 7(4), 249-257. Wong, C-K., & White, H. D. (2007). Elderly patients should not be denied fibrinolytic therapy. Nature Clinical Practice Cardiovascular Medicine, 4(10), 520-521.

Journal – Research Other Connor, A., Highton, J., Hung, N. A., Dunbar, J., MacGinley, R., & Walker, R. (2007). Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A: A case report and literature review. Amercian Journal of Kidney Diseases, 50(4), 649-654. Highton, J., Hessian, P. A., & Stamp, L. K. (2007). The Rheumatoid nodule: Peripheral or central to rheumatoid arthritis? [Editorial]. Rheumatology, 46, 1385-1387. Taylor, D. R., & Hall, I. P. (2007). ADRB2 polymorphisms and beta 2 agonists [Comment]. Lancet, 370, 2075-2076. Williams, M. (2007). Percutaneous coronary intervention in New Zealand [Editorial]. The New Zealand Medical Journal, 120(1248). http://www.nzma.org.nz/journal/120-1248/2398/

138 RESEARCH REPORT 2007/2008 Journal – Professional & Other Non-Research Articles McAuley, K. A., Mann, J. I., Chase, J. G., Lotz, T. F., & Shaw, G. M. (2007). Point: HOMA: Satisfactory for the time being: HOMA: The best bet for the simple determination of insulin sensitivity, until something better comes along [Editorial]. Diabetes Care, 30(9), 2411-2413. Taylor, D. R. (2007). Exhaled NO: Forward, backward, or sideways? American Journal of Respiratory and Critical Care Medicine, 176, 221-222. Yap, J., & Celi, L. A. (2007). Elderly access to medical care: Should age be a factor in deciding management? [Editorial]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2838/

DUNEDIN SCHOOL OF MEDICINE OPHTHALMOLOGY SECTION

Journal – Research Article Deokule, S. P., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2007). Long-term results on Molteno implant insertion in cases of chronic angle closure glaucoma. Clinical and Experimental Ophthalmology, 35, 514-519.

DUNEDIN SCHOOL OF MEDICINE ORTHOPAEDIC SURGERY SECTION

Journal – Research Article Chandler, N., Leichter, J., Oginni, A., & Jennings, M. (2007). Dens invaginatus: A rare case in a maxillary third molar. ENDO, 1(4), 279-282. Chiew, Y-F., & Theis, J-C. (2007). Comparison of infection rate using different methods of assessment for surveillance of total hip replacement surgical site infections. ANZ Journal of Surgery, 77, 535-539. Craig, R. A., Gwynne-Jones, D. P., Oakley, A. P., & Dunbar, J. D. (2007). Iliotibial band Z-lengthening for refractory trochanteric bursitis (greater trochanteric pain syndrome). ANZ Journal of Surgery, 77, 996-998. Lord, E. A., Martin, S. K., Gray, J. P., Li, C., & Clark, D. E. (2007). Cell cycle genes PEDF and CDKN1C in growing deer antlers. Anatomical Record, 290, 994-1004. Mcglashan, S. R., Haycraft, C. J., Jensen, C. G., Yoder, B. K., & Poole, C. A. (2007). Articular cartilage and growth plate defects are associated with chondrocyte cytoskeletal abnormalities in Tg737orpk mice lacking the primary cilia protein polaris. Matrix Biology, 26, 234-246. McGlashan, S. R., Jensen, C. G., & Poole, C. A. (2006). Localization of extracellular matrix receptors on the chondrocyte primary cilium. Journal of Histochemistry and Cytochemistry, 54(9), 1005-1014. Newsham-West, R., Nicholson, H., Walton, M., & Milburn, P. (2007). Long-term morphology of a healing bone-tendon interface: A histological observation in the sheep model. Journal of Anatomy, 210, 318-327. Ross, J. M., Sherwin, A. F., & Poole, C. A. (2006). In vitro culture of enzymatically isolated chondrons: A possible model for the initiation of osteoarthritis. Journal of Anatomy, 209, 793-806. Theis, J-C., Gambhir, S., & White, J. (2007). Factors affecting implant retention in infected joint replacements. ANZ Journal of Surgery, 77, 877-879.

Journal – Research Other Connor, A., Highton, J., Hung, N. A., Dunbar, J., MacGinley, R., & Walker, R. (2007). Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A: A case report and literature review. Amercian Journal of Kidney Diseases, 50(4), 649-654.

DUNEDIN SCHOOL OF MEDICINE SURGERY SECTION

Journal – Research Article Hayes, J. L., & Hansen, P. (2007). Is laparoscopic colectomy for cancer cost-effective relative to open colectomy? ANZ Journal of Surgery, 77, 782-786. Hill, G., Albayati, S., Thomson, I., Macfarlane, J., Dutton, S., & van Rij, A. M. (2007). Iatrogenic pseudoaneurysms: Optimal management and treatment options. Journal for Vascular Ultrasound, 31(3), 131-135. Jiang, F., Jones, G. T., & Dusting, G. J. (2007). Failure of antioxidants to protect against angiotensin II-induced aortic rupture in aged apolipoprotein(E)-deficient mice. British Journal of Pharmacology, 152, 880-890. Jones, G. T., van Rij, A. M., Cole, J., Williams, M. J. A., Bateman, E. H., Marcovina, S. M., Deng, M., & McCormick, S. P. (2007). Plasma lipoprotein(a) indicates risk for 4 distinct forms of vascular disease. Clinical Chemistry, 53(4), 679-685.

Division of HEALTH SCIENCES 139 Lin, Y-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, L. V., Thompson-Fawcett, M., Kasabov, N., Toro, T., Merrie, A. E., van Rij, A., Yoon, H-S., McCall, J. L., Siewert, J. R., Holzmann, B., & Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clincial Cancer Research, 13(2), 498-507. Macassey, E. A., Baguley, C., Dawes, P., & Gray, A. (2007). 15-year audit of post-tonsillectomy haemorrhage at Dunedin Hospital. ANZ Journal of Surgery, 77, 579-582. Thompson-Fawcett, M. W., McC Mortensen, N. J., Jewel, D. P., & Warren, B. F. (2007). Use of monoclonal antibody to sucrase- isomaltase for evaluation of the columnar cuff after stapled restorative proctocolectomy. Diseases of the Colon & Rectum, 50(9), 1428-1435. Thomson, I. (2007). Abdominal aortic aneurysm: Can we improve on current management? The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2462/ Welch, D., & Dawes, P. J. D. (2007). Childhood hearing is associated with growth rates in infancy and adolescence. Pediatric Research, 62(4), 495-498. Welch, D., & Dawes, P. J. D. (2007). No negative outcomes of childhood middle ear disease in adulthood. The Laryngoscope, 117, 466-469. Welch, D., & Dawes, P. J. D. (2007). Variation in the normal hearing threshold predicts childhood IQ, linguistic, and behavioural outcomes. Pediatric Research, 61(6), 737-744. Woodfield, J. C., Beshay, N. M. Y., Pettigrew, R. A., Plank, L. D., & van Rij, A. M. (2007). American society of anesthesiologists classification of physical status as a predictor of wound infection. ANZ Journal of Surgery, 77, 738-741. Woodfield, J. C., Pettigrew, R. A., Plank, L. D., Landmann, M., & van Rij, A. M. (2007). Accuracy of the surgeons’ clinical prediction of perioperative complications using a visual analog scale. World Journal of Surgery, 31, 1912-1920.

Journal – Research Other Gilbert, J. G., Dawes, P. J., Mahadevan, M., Baber, W. J., & Hall, F. (2007). Use of ototoxic eardrops: A position statement from the New Zealand Society of Otolaryngology Head and Neck Surgery [Letter]. The New Zealand Medical Journal, 120(1258). http://www.nzma.org.nz/journal/120-1258/2646/ Welch, D., & Dawes, P. (2007, November). Normal variation in the hearing threshold is associated with behavioural and neurodevelopmental factors. Verbal presentation at the 60th Annual General and Scientific Meeting of the New Zealand Society of Otolaryngology Head and Neck Surgery, Queenstown, New Zealand. Yule, A. G. (2007, May). The New Zealand mobile surgical service: Five years on the road. Verbal presentation at the 76th Annual Scientific Congress, Christchurch, New Zealand.

DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF PATHOLOGY

Journal – Research Article Connor, A., Stebbings, S. M., Hung, N. A., Hammond-Tooke, G., Meikle, G., & Highton, J. (2007). STIR MRI to direct muscle biopsy in suspected idiopathic inflammatory myopathy. Journal of Clinical Rheumatology, 13(6), 341-345. Dear, A., Brennan, S., Sheat, J. M., Faed, J. M., & George, P. M. (2007). Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin light chain. Haematologica, 92, e111-e117. Highton, J., Hung, N., Hessian, P., & Wilsher, M. (2007). Pulmonary rheumatoid nodules demonstrating features usually associated with rheumatoid synovial membrane. Rheumatology, 46, 811-814. Horsfield, J. A., Anagnostou, S. H., Hu, J. K-H., Cho, K. H. Y., Geisler, R., Lieschke, G., Crosier, K. E., & Crosier, P. S. (2007). Cohesin-dependent regulation of Runx genes. Development, 134, 2639-2649. Lin, Y-H., Friederichs, J., Black, M. A., Mages, J., Rosenberg, R., Guilford, P. J., Phillips, L. V., Thompson-Fawcett, M., Kasabov, N., Toro, T., Merrie, A. E., van Rij, A., Yoon, H-S., McCall, J. L., Siewert, J. R., Holzmann, B., & Reeve, A. E. (2007). Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clincial Cancer Research, 13(2), 498-507. Lu, W., van Eerde, A. M., Fan, X., ..., Eccles, M. R., et al. (2007). Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. American Journal of Human Genetics, 80, 616-632. Schimmenti, L. A., & Eccles, M. R. (2007). Renal coloboma syndrome [Papillorenal syndrome]. GeneReviews. http://www. geneclinics.org/profiles/all.html#R Wilson, J. C., Yoon, H-S., Walker, R. J., & Eccles, R. R. (2007). A novel Cys1638Tyr NC1 domain substitution in 〈5(IV) collagen causes Alport syndrome with late onset renal failure without hearing loss or eye abnormalities. Nephrology Dialysis Transplantation, 22(5), 1338-1346.

Journal – Research Other Connor, A., Highton, J., Hung, N. A., Dunbar, J., MacGinley, R., & Walker, R. (2007). Multicentric carpal-tarsal osteolysis with nephropathy treated successfully with cyclosporine A: A case report and literature review. Amercian Journal of Kidney Diseases, 50(4), 649-654. Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the Editor]. Molecular Psychiatry, 12, 899-900.

140 RESEARCH REPORT 2007/2008 DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF PREVENTIVE AND SOCIAL MEDICINE

Chapter in Book – Research Baxter, J. (2007). Mental health: Psychiatric disorder and suicide. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-20005 (pp. 121-139). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Hay-Smith, E. J. C., Dumoulin, C. L., & Herbison, P. (2007). Pelvic floor muscle training for urinary incontinence in women. In C. Webb & B. Roe (Eds.), Reviewing Research Evidence for Nursing Practice: Systematic Reviews (pp. 31-50). Oxford, UK: Blackwell.

Chapter in Book – Textbook & Other Broughton, J. (2007). Mäori rugby on tour: 1926-27. In S. Strachan & L. Tyler (Eds.), Kä Taoka Häkena: Treasures from the Hocken Collections (pp. 63). Dunedin, New Zealand: Otago University Press.

Journal – Research Article Adetifa, I. M. O., Lugos, M. D., Hammond, A., Jeffries, D., Donkor, S., Adegbola, R. A., & Hill, P. C. (2007). Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia. BMC Infectious Diseases, 7. http://www.biomedcentral.com/1471-2334/7/122 Barton, A., Basham, M., Foy, C., Buckingham, K., & Somerville, M. (2007). The Watcombe Housing Study: The short term effect of improving housing conditions on the health of residents. Journal of Epidemiology & Community Health, 61, 771-777. Beautrais, A., Fergusson, D., Coggan, C., Collings, C., Doughty, C., Ellis, P., Hatcher, S., Horwood, J., Merry, S., Mulder, R., Poulton, R., & Surgenor, L. (2007). Effective strategies for suicide prevention in New Zealand: A review of the evidence. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2459/ Bell, M. L., Earl, J. B., & Britt, S. G. (2007). Two types of Drosophila R7 photoreceptor cells are arranged randomly: A model for stochastic cell-fate determination. The Journal of Comparative Neurology, 502, 75-85. Burl, S., Hill, P. C., Jeffries, D. J., Holland, M. J., Fox, A. D., Lugos, M. D., Adegbola, R. A., Rook, G. A., Zumla, A., McAdam, K. P. W. J., & Brookes, R. H. (2007). FOXP3 gene expression in a tuberculosis case contact study. Clinical and Experimental Immunology, 149, 117-122. Carter, M. J., McGee, R. O., Taylor, B. J., & Williams, S. M. (2007). Health outcomes in adolescence: Associations with family, friends and school engagement. Journal of Adolescence, 30, 51-62. Cashell-Smith, M. L., Connor, J., & Kypri, K. (2007). Harmful effects of alcohol on sexual behaviour in a New Zealand university community. Drug and Alcohol Review, 26, 645-651. Caspi, A., Williams, B., Kim-Cohen, J., Craig, I. W., Milne, B. J., Poulton, R., Schalkwyk, L. C., Taylor, A., Werts, H., & Moffitt, T. E. (2007). Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. PNAS, 104(47), 18860-18865. Cehovin, A., Cliff, J. M., Hill, P. C., Brookes, R. H., & Dockrell, H. M. (2007). Extended culture enhances sensitivity of a gamma interferon assay for latent Mycobacterium tuberculosis infection. Clinical and Vaccine Immunology, 14(6), 796-798. Conlon, N. P., Sullivan, R. P., Herbison, P. G., Zacharias, M., & Buggy, D. J. (2007). The effect of leaving dentures in place on bag-mask ventilation at induction of general anesthesia. Ambulatory Anesthesiology, 105(2), 370-373. Cox, A., Dunning, A. M., Garcia-Closas, M., Balasubramanian, S., Reed, M. W. R., McCredie, M. R. E., et al. (2007). A common coding variant in CASP8 is associated with breast cancer risk. Nature Genetics, 39(3), 352-358. Crowe, F. L., Skeaff, C. M., Green, T. J., & Gray, A. R. (2007). Serum phospholipid n-3 long-chain polyunsaturated fatty acids and physical and mental health in a population-based survey of New Zealand adolescents and adults. American Journal of Clinical Nutrition, 86, 1278-1285. Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007). Childhood maltreatment predicts adult inflammation in a life-course study. PNAS, 104(4), 1319-1324. Davie, G. S., Baker, M. G., Hales, S., & Carlin, J. B. (2007). Trends and determinants of excess winter mortality in New Zealand: 1980 to 2000. BMC Public Health, 7. http://www.biomedcentral.com/1471-2458/7/263 Davis, P., Lay-Yee, R., Scott, A., & Gauld, R. (2007). Do hospital bed reduction and multiple system reform affect patient mortality? A trend and multilevel analysis in New Zealand over the period 1988-2001. Medical Care, 45, 1186-1194. Day, L., Langley, J., Stathakis, V., Wolfe, R., Sim, M., Voaklander, D., & Ozanne-Smith, J. (2007). Challenges of recruiting farm injury study participants through hospital emergency departments. Injury Prevention, 13, 88-92. Dean, N. M., Ellis, G., Wilson, P. D., & Herbison, G. P. (2007). Laparoscopic colposuspension for urinary incontinence in women (Review). Cochrane Database of Systematic Reviews, 3(CD002239). http://www.mrw.interscience.wiley.com/ cochrane/clsysrev/articles/CD002239/frame.html de Jong, B. C., Hill, P. C., Aiken, A., Jeffries, D. J., Onipede, A., Small, P. M., Adegbola, R. A., & Corrah, T. P. (2007). Clinical presentation and outcome of tuberculosis patients infected by M. africanum versus M. tuberculosis. International Journal of Tuberculosis and Lung Disease, 11(4), 450-456. Delahunt, B., Bethwaite, P. B., McCredie, M. R., & Nacey, J. N. (2007). The evolution of collagen expression in sarcomatoid renal cell carcinoma. Human Pathology, 38, 1372-1377.

Division of HEALTH SCIENCES 141 Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R., Martignoni, G., Eble, J., & Jordan, T. W. (2007). Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. American Journal of Surgical Pathology, 31(6), 957-960. Dennison, J., Healey, D., & Herbison, P. (2007). The Polynesian chin and mandible. Anthropologischer Anzeiger, 65, 241-252. Deokule, S. P., Molteno, A. C. B., Bevin, T. H., & Herbison, P. (2007). Long-term results on Molteno implant insertion in cases of chronic angle closure glaucoma. Clinical and Experimental Ophthalmology, 35, 514-519. Dickson, N., van Roode, T., Herbison, P., Taylor, J., Cunningham, A., & Paul, C. E. (2007). Risk of herpes simplex virus type 2 acquisition increases over early adulthood: Evidence from a cohort study. Sexually Transmitted Infections, 83(2), 87-90. Dockerty, J. D., Herbison, P., Skegg, D. C. G., & Elwood, M. (2007). Vitamin and mineral supplements in pregnancy and the risk of childhood acute lymphoblastic leukaemia: A case-control study. BMC Public Health, 7(136). http://www. biomedcentral.com/content/pdf/1471-2458-7-136.pdf Douglas, N. M., & Dockerty, J. D. (2007). Survival by ethnicity for children diagnosed with cancer in New Zealand during 1990-1993. Journal of Paediatrics and Child Health, 43, 173-177. Duthie, J., Wilson, D. I., Herbison, G. P., & Wilson, D. (2007). Botulinum toxin injections for adults with overactive bladder syndrome (Review). Cochrane Database of Systematic Reviews, 3(CD005493). http://www.mrw.interscience.wiley.com/ cochrane/clsysrev/articles/CD005493/pdf_fs.html Easton, D. F., Pooley, K. A., Dunning, A. M., Pharoah, P. D. P., Thompson, D. A., McCredie, M., et al. (2007). Genome-wide association study identifies novel breast cancer susceptibility loci. Nature, 447, 1087-1095. Findlay, M., Sharples, K., Riley, G. A., Simpson, A., Ackland, S., Hall, K., Isaacs, R., Humm, G., & McKeage, M. J. (2007). Capecitabine and oral cyclophosphamide: A novel oral treatment combination for advanced cancer. Asia-Pacific Journal of Clinical Oncology, 3, 99-105. Firth, H., Gray, A., Carpenter, L. M., & Cox, B. (2007). Cancer mortality by occupation among New Zealand women: 1988- 1997. The New Zealand Medical Journal, 120(1266). Firth, H. M., Rothstein, D. S., Herbison, G. P., & McBride, D. I. (2007). Chemical exposure among NZ farmers. International Journal of Environmental Health Research, 17(1), 33-43. Firth, H. M., Williams, S. M., Herbison, G. P., & McGee, R. O. (2007). Stress in New Zealand farmers. Stress and Health, 23, 51-58. Fleming, J. S., McQuillan, H. J., Millier, M. J., Beaugié, C. R., & Livingstone, V. (2007). E-cadherin expression and bromodeoxyuridine incorporation during development of ovarian inclusion cysts in age-matched breeder and incessantly ovulated CD-1 mice. Reproductive Biology and Endocrinology, 5. http://www.rbej.com/content/pdf/1477-7827-5-14.pdf Fox, A. D., Jeffries, D. J., Hill, P. C., Hammond, A. S., Lugos, M. D., Jackson-Sillah, D., Donkor, S. A., Owiafe, P. K., McAdam, K. P. W. J., & Brookes, R. H. (2007). ESAT-6 and CFP-10 can be combined to reduce the cost of testing for Mycobacterium tuberculosis infection, but CFP-10 responses associate with active disease. Transactions of the Royal Society of Tropical Medicine and Hygiene, 101, 691-698. Gauld, R. (2007). Health care in Singapore. Asian Journal of Social Policy, 3/2, 23-39. Gauld, R. (2007). New Zealand’s health system: National policy goals and decentralized service planning and delivery. American Heart Hospital Journal, 5, 177-181. Gauld, R. (2007). Principal-agent theory and organisational change: Lessons from New Zealand health information management. Policy Studies, 28(1), 17-34. Gauld, R. (2007). Public sector information system project failures: Lessons from a New Zealand hospital organization. Government Information Quarterly, 24, 102-114. Gauld, R. (2007). Which way forward? An analysis of Hong Kong’s health system reform options. The Asia Pacific Journal of Public Administration, 29(2), 173-190. Goulding, A., Grant, A. M., Taylor, R. W., Williams, S. M., Parnell, W. R., Wilson, N., & Mann, J. (2007). Ethnic differences in extreme obesity. Journal of Pediatrics, 151, 542-544. Green, T. J., McMahon, J. A., Skeaff, C. M., Williams, S. M., & Whiting, S. J. (2007). Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: A 2-y randomized controlled trial. American Journal of Clinical Nutrition, 85, 460-464. Gregory, A. M., Caspi, A., Moffitt, T. E., Koenen, K. C., Eley, T. C., & Poulton, R. (2007). Juvenile mental health histories of adults with anxiety disorders. American Journal of Psychiatry, 164, 301-308. Grenier, D., Elliott, E. J., Zurynski, Y., Pereira, R. R., Preece, M., Lynn, R., von Kries, R., Zimmermann, H., Dickson, N. P., & Virella, D. (2007). Beyond counting cases: Public health impacts of national Paediatric Surveillance Units. Archives of Disease in Childhood, 92, 527-533. Gulliver, P., & Begg, D. (2007). Personality factors as predictors of persistent risky driving behavior and crash involvement among young adults. Injury Prevention, 13, 376-381. Hamilton, S., Ni Mhurchu, C., & Priest, P. (2007). Food and nutrient availability in New Zealand: An analysis of supermarket sales data. Public Health Nutrition, 10(12), 1448-1455. Hammond-Tooke, G. D., Taylor, P., Punchihewa, S., & Beasley, M. (2007). Urtica ferox neuropathy. Muscle and Nerve, 35, 804-807. Hancox, R. J., Poulton, R., Greene, J. M., Filsell, S., McLachlan, C. R., Rasmussen, F., Taylor, D. R., Williams, M. J. A., Williamson, A., & Sears, M. R. (2007). Systemic inflammation and lung function in young adults. Thorax, 62, 1064-1068. Harrison-Woolrych, M., Garcia-Quiroga, J., Ashton, J. A., & Herbison, G.P. (2007). Safety and usage of atypical antipsychotic medicines in children: A nationwide prospective cohort study. Drug Safety, 30(7), 569-579. Head, R. F., Tu, Y-K., Gilthorpe, M. S., Mishra, G. D., Williams, S., & Ellison, G. T. H. (2007). What evidence is there that adjustment for adult height influences the relationship between birth weight and blood pressure? Annals of Human Biology, 34(2), 252-264.

142 RESEARCH REPORT 2007/2008 Hetrick, S., Merry, S., McKenzie, J., Sindahl, P., & Proctor, M. (2007). Selective serotonin reuptake inhibitors (SSRIs) for depressive disorders in children and adolescents (Review). Cochrane Database of Systematic Reviews, (3), CD004851. Hickey, B. W., Milosavljevic, S., Bell, M. L., & Milburn, P. D. (2007). Accuracy and reliability of observational motion analysis in identifying shoulder symptoms. Manual Therapy, 12, 263-270. Hill, G. R., Ashton, J., & Harrison-Woolrych, M. (2007). Sibutramine usage in New Zealand: An analysis of prescription data by the Intensive Medicines Monitoring Programme. Pharmacoepidemiology and Drug Safety, 16, 1217-1226. Hill, P. C., Brookes, R. H., Fox, A., Jackson-Sillah, D., Jeffries, D. J., Lugos, M. D., Donkor, S. A., Adetifa, I. M., de Jong, B. C., Aiken, A., Adegbola, R. A., & McAdam, K. P. (2007). Longitudinal assessment of an ELISPOT test for Mycobacterium tuberculosis infection. PLoS Medicine, 4(6), 1061-1070. Hill, P. C., Jeffries, D. J., Brookes, R. H., Fox, A., Jackson-Sillah, D., Lugos, M. D., Donkor, S. A., de Jong, B. C., Corrah, T., Adegbola, R. A., & McAdam, K. P. (2007). Using ELISPOT to expose false positive skin test conversion in tuberculosis contacts. PLoS ONE, 2(1), 1-6. Hill, P. C., Onyeama, C. O., Ikumapayi, U. N. A., Secka, O., Ameyaw, S., Simmonds, N., Donkor, S. A., Howie, S. R., Tapgun, M., Corrah, T., & Adegbola, R. A. (2007). Bacteraemia in patients admitted to an urban hospital in West Africa. BMC Infectious Diseases, 7. http://www.biomedcentral.com/1471-2334/7/2 Howden-Chapman, P. L., Matheson, A., Crane, J., Viggers, H. E., Cunningham, M., Blakely, T. A., Cunningham, C., Woodward, A., Saville-Smith, K., O’Dea, D., Kennedy, M., Baker, M. G., Waipara, N., Chapman, R., & Davie, G. S. (2007). Effect of insulating existing houses on health inequality: Cluster randomised study in the community. BMJ, 334, 460. http://www. bmj.com/cgi/content/full/334/7591/460 Jackson-Sillah, D., Hill, P. C., Fox, A. D., Brookes, R. H., Donkor, S. A., Lugos, M. D., Howie, S. R. C., Fielding, K. R., Jallow, A., Lienhardt, C., Corrah, T. P., Adegbola, R. A., & McAdam, K. P. W. J. (2007). Screening for tuberculosis among 2381 household contacts of sputum-smear-positive cases in The Gambia. Transaction of the Royal Society of Tropical Medicine and Hygiene, 101, 594-601. Jenks, K. A., Stamp, L. K., O’Donnell, J. L., Savage, R. L., & Chapman, P. T. (2007). Leflunomide-associated infections in rheumatoid arthritis. Journal of Rheumatology, 34, 2201-2203. Jordan, C. A., Livingstone, V., & Barry, D. M. J. (2007). Statistical modelling using product partition models. Statistical Modelling, 7(3), 275-295. Karam, E. G., Kypri, K., & Salamoun, M. (2007). Alcohol use among college students: An international perspective. Current Opinion in Psychiatry, 20, 213-221. Kerr, P. G., Sutherland, W. H. F., de Jong, S., Vaithalingham, I., Williams, S. M., & Walker, R. J. (2007). The impact of standard high-flux polysulfone versus novel high-flux polysulfone dialysis membranes on inflammatory markers: A randomized, single-blinded, controlled clinical trial. American Journal of Kidney Diseases, 49(4), 533-539. Kerruish, N. J., Campbell-Stokes, P. L., Gray, A., Merriman, T. R., Robertson, S. P., & Taylor, B. J. (2007). Maternal psychological reaction to newborn genetic screening for type 1 diabetes. Pediatrics, 120(2), e324-e335. Koenen, K. C., Moffitt, T. E., Poulton, R., Martin, J., & Caspi, A. (2007). Early childhood factors associated with the development of poat-traumatic stress disorder: Results from a longitudinal birth cohort. Psychological Medicine, 37, 181-192. Kypri, K. (2007). Methodological issues in alcohol screening and brief intervention research. Substance Abuse, 28(3), 31-42. Kypri, K., Dean, J. I., & Stojanovski, E. (2007). Parent attitudes on the supply of alcohol to minors. Drug and Alcohol Review, 26, 41-47. Kypri, K., Paschall, M. J., Maclennan, B., & Langley, J. D. (2007). Intoxication by drinking location: A web-based diary study in a New Zealand university community. Addictive Behaviors, 32, 2586-2596. Landhuis, C. E., Poulton, R., Welch, D., & Hancox, R. J. (2007). Does childhood television lead to attention problems in adolescence? Results from a prospective longitudinal study. Pediatrics, 120, 532-537. Langley, J. D., Davie, G. S., & Simpson, J. C. (2007). Quality of hospital discharge data for injury prevention. Injury Prevention, 13, 42-44. Macassey, E. A., Baguley, C., Dawes, P., & Gray, A. (2007). 15-year audit of post-tonsillectomy haemorrhage at Dunedin Hospital. ANZ Journal of Surgery, 77, 579-582. Marie, D., & Miles, B. (2007). Does social group status influence social distance in relation to depression? New Zealand Journal of Psychology, 36(1), 34-41. Marsh, L., McGee, R., Nada-Raja, S., & Currey, N. (2007). Adolescents’ perceptions of violence and its prevention. Australian and New Zealand Journal of Public Health, 31(3), 224-229. McAnally, H. M., Poulton, R. G., Hancox, R. J., Prescott, J., & Welch, D. (2007). Psychosocial correlates of 6-n-propylthiouracil (PROP) ratings in a birth cohort. Appetite, 49, 700-703. McAnally, H. M., Poulton, R., Hancox, R. J., Prescott, J., & Welch, D. (2007). Psychosocial predictors of 6-n-propylthiouracil (PROP) ratings in a birth cohort. Appetite, 49, 700-703. McGee, R. (2007). Inattention and hyperactivity: What findings from the Dunedin (NZ) longitudinal study have told us. Patoss Bulletin, 20(2), 14-19. McGee, R., Ketchel, J., & Reeder, A. I. (2007). Alcohol imagery on New Zealand television. Substance Abuse Treatment, Prevention, and Policy, 2(6). http://www.substanceabusepolicy.com/content/pdf/1747-597X-2-6.pdf McGillivray, G., Skull, S. A., Davie, G., Kofoed, S. E., Frydenberg, A., Rice, J., Cooke, R., & Carapetis, J. R. (2007). High prevalence of asymptomatic vitamin D and iron deficiency in East African immigrant children and adolescents living in a temperate climate. Archives of Disease in Childhood, 92, 1088-1093.

Division of HEALTH SCIENCES 143 McLachlan, C. R., Poulton, R., Car, G., Cowan, J., Filsell, S., Greene, J., Taylor, D. R., Welch, D., Williamson, A., Sears, M. R., & Hancox, R. J. (2007). Adiposity, asthma, and airway inflammation. Journal of Allergy and Clinical Immunology, 119(3), 634-639. McLay, R. T., Thomson, C. D., Williams, S. M., & Rehrer, N. J. (2007). Carbohydrate loading and female endurance athletes: Effect of menstrual-cycle phase. International Journal of Sport Nutrition and Exercise Metabolism, 17, 189-205. McLean, R. M., & Harrison-Woolrych, M. (2007). Alopecia associated with quetiapine. International Clinical Psychopharmacology, 22(2), 117-119. McMahon, J. A., Skeaff, C. M., Williams, S. M., & Green, T. J. (2007). Lowering homocysteine with B vitamins has no effect on blood pressure in older adults. Journal of Nutrition, 137(4), 1183-1187. McNicholas, A., Galloway, Y., Stehr-Green, P., Tatley, M. V., et al. (2007). Post-marketing safety monitoring of a new group B meningococcal vaccine in New Zealand, 2004-2006. Human Vaccines, 3(5), 196-204. Melchior, M., Caspi, A., Milne, B. J., Danese, A., Poulton, R., & Moffitt, T. E. (2007). Work stress precipitates depression and anxiety in young, working women and men. Psychological Medicine, 37, 1119-1129. Melchior, M., Moffitt, T. E., Milne, B. J., Poulton, R., & Caspi, A. (2007). Why do children from socioeconomically disadvantaged families suffer from poor health when they reach adulthood? A life-course study. American Journal of Epidemiology, 166(8), 966-974. Miller, J. C., Grant, A. M., Drummond, B. F., Williams, S. M., Taylor, R. W., & Goulding, A. (2007). DXA measurements confirm that parental perceptions of elevated adiposity in young children are poor. Obesity, 15(1), 165-171. Moffitt, T. E., Caspi, A., Harrington, H., Milne, B. J., Melchior, M., Goldberg, D., & Poulton, R. (2007). Generalized anxiety disorder and depression: Childhood risk factors in a birth cohort followed to age 32. Psychological Medicine, 37, 441-452. Moffitt, T. E., Harrington, H., Caspi, A., Kim-Cohen, J., Goldberg, D., Gregory, A. M., & Poulton, R. (2007). Depression and Generalized Anxiety Disorder: Cumulative and sequential comorbidity in a birth cohort followed prospectively to age 32 years. Archives of General Psychiatry, 64, 651-660. Moore, T., Gauld, R., & Williams, S. (2007). Implementing Baby Friendly Hospital Initiative policy: The case of New Zealand public hospitals. International Breastfeeding Journal, 2. http://www.internationalbreastfeedingjournal.com/content/2/1/8 Nabi, G., Cody, J. D., Ellis, G., Herbison, P., & Hay-Smith, J. (2007). Anticholinergic drugs versus placebo for overactive bladder syndrome in adults (Review). Cochrane Database of Systematic Reviews, 4, CD003781. Nairn, K. M., Higgins, J., & Sligo, J. (2007). Youth researching youth: Trading on subcultural capital in peer research methodologies. Teachers College Record, (14515). Newcombe, R., Milne, B. J., Caspi, A., Poulton, R., & Moffitt, T. E. (2007). Birthweight predicts IQ: Fact or artefact? Twin Research and Human Genetics, 10(4), 581-586. Nisbet, S. M., Reeve, A. M., Ellis-Pegler, R. B., Woodhouse, A. F., Ingram, R. J., Roberts, S. A., McAllister, S. M., & Thomas, M. G. (2007). Good outcome in HIV-infected refugees after resettlement in New Zealand: Population study. Internal Medicine Journal, 37, 290-294. Odgers, C. L., Caspi, A., Broadbent, J. M., Dickson, N., Hancox, R. J., Harrington, H., Poulton, R., Sears, M. R., Thomson, W. M., & Moffitt, T. E. (2007). Prediction of differential adult health burden by conduct problem subtypes in males. Archives of General Psychiatry, 64, 476-484. Odgers, C. L., Milne, B. J., Caspi, A., Crump, R., Poulton, R., & Moffitt, T. E. (2007). Predicting prognosis for the conduct-problem boy: Can family history help? Journal of the American Academy of Child & Adolescent Psychiatry, 46(10), 124-1249. Olesen, R., Wejse, C., Velez, D. R., Bisseye, C., Sodemann, M., Aaby, P., Rabna, P., Worwui, A., Chapman, H., Diatta, M., Adegbola, R. A., Hill, P. C., et al. (2007). DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. Genes and Immunity, 8, 456-467. Ota, M. O. C., Brookes, R. H., Hill, P. C., Owiafe, P. K., Ibanga, H. B., Donkor, S., Awine, T., McShane, H., & Adegbola, R. A. (2007). The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo. Vaccine, 25, 8861-8867. Paterson, H., Clifton, J., Miller, D., Ashton, J., & Harrison-Woolrych, M. (2007). Hair loss with use of the levonorgestrel intrauterine device. Contraception, 76, 306-309. Priest, P., Sadler, L., Peters, J., Crengle, S., Bethwaite, P. B., Medley, G., & Jackson, R. (2007). Pathways to diagnosis of cervical cancer: Screening history, delay in follow up, and smear reading. BJOG: An International Journal of Obstetrics & Gynaecology, 114, 398-407. Ramrakha, S., Bell, M. L., Paul, C., Dickson, N., Moffitt, T. E., & Caspi, A. (2007). Childhood behavior problems linked to sexual risk taking in young adulthood: A birth cohort study. Journal of the American Academy of Child & Adolescent Psychiatry, 46(10), 1272-1279. Richards, R., Williams, S., Poulton, R., & Reeder, A. I. (2007). Tracking club sport participation from childhood to early adulthood. Research Quarterly for Exercise and Sport, 78(5), 413-419. Sharp, C., Harkness, M., & Herbison, P. (2007). Vertical changes in treated and untreated Class II division I malocclusions. Australian Orthodontic Journal, 23(2), 114-120. Sims, S. T., Rehrer, N. J., Bell, M. L., & Cotter, J. D. (2007). Preexercise sodium loading aids fluid balance and endurance for women exercising in the heat. Journal of Applied Physiology, 103, 534-541. Skegg, K. M., Nada-Raja, S., Paul, C. E., & Skegg, D. C. (2007). Body piercing, personality, and sexual behaviour. Archives of Sexual Behavior, 36, 47-54.

144 RESEARCH REPORT 2007/2008 Smith, L. D., Tesoriero, A. A., Ramus, S. J., Dite, G., Royce, S. G., Giles, G. G., McCredie, M. R. E., Hopper, J. L., & Southey, M. C. (2007). BRCA1 promoter deletions in young women with breast cancer and a strong family history: A population-based study. European Journal of Cancer, 43, 823-827. Spurdle, A. B., Chang, J-H., Byrnes, G. B., Chen, X., Dite, G. S., McCredie, M. R. E., Giles, G. G., Southey, M. C., Chenevix- Trench, G., & Hopper, J. L. (2007). A systematic approach to analysing gene-gene interactions: Polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1 and GSTP1 loci and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention, 16(4), 769-774. Stevens, W., Stevens, G., Kolbe, J., & Cox, B. (2007). Lung cancer in New Zealand: Patterns of secondary care and implications for survival. Journal of Thoracic Oncology, 2(6), 481-493. Stewart, J. H., McCredie, M. R. E., Williams, S. M., Jager, K. J., Trpeski, L., McDonald, S. P., & for The ESRD Incidence Study Group (2007). Trends in incidence of treated end-stage renal disease, overall and by primary renal disease, in persons aged 20-64 years in Europe, Canada and the Asia-Pacific region, 1999-2002. Nephrology, 12, 520-527. Sutherland, T. J. T., Taylor, D. R., Sears, M. R., Cowan, J. O., McLachlan, C. R., Filsell, S., Williamson, A., Greene, J. M., Poulton, R., & Hancox, R. J. (2007). Association between exhaled nitric oxide and systemic inflammatory markers. Annals of Allergy, Asthma & Immunology, 99(4), 334-339. Takemura, M., Schneiders, A. G., Bell, M. L., & Milburn, P. D. (2007). Association of ground hardness with injuries in rugby union. British Journal of Sports Medicine, 41, 582-587. Tang, E. W., Wong, C-K., & Herbison, P. (2007). Global registry of acute coronary events (GRACE) hospital discharge risk score accurately predicts long-term mortality post acute coronary syndrome. American Heart Journal, 153, 29-35. Tatley, M., & Savage, R. (2007). Psychiatric adverse reactions with statins, fibrates and ezetimibe: Implications for the use of lipid-lowering agents. Drug Safety, 30(3), 195-201. Taylor, D. R., Mandhane, P., Greene, J. M., Hancox, R. J., Filsell, S., McLachlan, C. R., Williamson, A. J., Cowan, J. O., Smith, A. D., & Sears, M. R. (2007). Factors affecting exhaled nitric oxide measurements: The effect of sex. Respiratory Research, 8. http://respiratory-research.com/content/8/1/82 Taylor, R. W., McAuley, K. A., Barbezat, W., Strong, A., Williams, S. M., & Mann, J. I. (2007). APPLE project: 2-y findings of a community-based obesity prevention program in primary school-age children. American Journal of Clinical Nutrition, 86, 735-742. Thomson, W. M., Broadbent, J. M., Welch, D., Beck, J. D., & Poulton, R. (2007). Cigarette smoking and periodontal disease among 32-year-olds: A prospective study of a representative birth cohort. Journal of Clinical Periodontology, 34, 828-834. Thomson, W. M., Poulton, R., Hancox, R. J., Ryan, K. M., & Al-Kubaisy, S. (2007). Changes in medication use from age 26 to 32 in a representative birth cohort. Internal Medicine Journal, 37, 543-549. Trevena, J., & Reeder, A. (2007). Perceptions of New Zealand adults about reducing their risk of getting cancer. The New Zealand Medical Journal, 120(1258). http://www.nzma.org.nz/journal/120-1258/2630/ Vajdic, C. M., van Leeuwen, M. T., McDonald, S. P., McCredie, M. R. E., Law, M., Chapman, J. R., Webster, A. C., Kaldor, J. M., & Grulich, A. E. (2007). Increased incidence of squamous cell carcinoma of eye after kidney transplantation. Journal of the National Cancer Institute, 99(17), 1340-1342. Waldie, K. E., & Welch, D. (2007). Cognitive function in tension-type headache. Current Pain and Headache Reports, 11, 454-460. Walker, J., & Darling, H. (2007). Tobacco education: Have New Zealand primary schools done their homework? Australian and New Zealand Journal of Public Health, 31(1), 23-25. Welch, D., & Dawes, P. J. D. (2007). Childhood hearing is associated with growth rates in infancy and adolescence. Pediatric Research, 62(4), 495-498. Welch, D., & Dawes, P. J. D. (2007). No negative outcomes of childhood middle ear disease in adulthood. The Laryngoscope, 117, 466-469. Welch, D., & Dawes, P. J. D. (2007). Variation in the normal hearing threshold predicts childhood IQ, linguistic, and behavioural outcomes. Pediatric Research, 61(6), 737-744. Wong, C-K., Tang, E. W., & Herbison, P. (2007). Survival over 5 years in the initial hospital surviviors with acute coronary syndrome: A comparison between a community hospital and a tertiary hospital in New Zealand. The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/journal/120-1261/2713/ Wright, C. Y., Reeder, A. I., Bodeker, G. E., Gray, A., & Cox, B. (2007). Solar UVR exposure, concurrent activities and sun- protective practices among primary schoolchildren. Photochemistry and Photobiology, 83, 749-758.

Journal – Research Other Adetifa, I. M. O., Brookes, R., Lugos, M. D., de Jong, B. C., Antonio, M., Adegbola, R. A., & Hill, P. C. (2007). Rising ELISPOT count prior to the onset of symptoms of full-blown tuberculosis disease [Short communication]. International Journal of Tuberculosis and Lung Disease, 11(3), 350-352. Connor, J., & McGee, R. (2007). Raising non-smokers. The New Zealand Medical Journal, 120(1267). http://www.nzma.org. nz/journal/120-1267/2865/ Cox, B. (2007). Trading PREDICTions [Editorial]. The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/ journal/120-1261/2707/ Harrison-Woolrych, M. L. (2007). Evaluating medicines: Let’s use all the evidence. Medical Journal of Australia, 186(12), 662. Herbison, P. (2007). Are they different, the same, or is one no worse and does it make a clinical difference? [Editorial]. Neurourology and Urodynamics, 26, 323-324.

Division of HEALTH SCIENCES 145 Herbison, P. (2007). How to make your article more acceptable for the statistical reviewer [Editorial]. Neurourology and Urodynamics, 26, 318-322. Herbison, P. (2007). Why would anyone be interested in measurement error? [Comment]. Australian Orthodontic Journal, 23(2), 156-157. Langley, J. (2007). On the importance of methods [Editorial]. Injury Prevention, 13, 218.

Journal – Professional & Other Non-Research Articles Gauld, R. (2007). [Review of the book Chinese Medicine Men: Consumer culture in China and Southeast Asia]. New Zealand Journal of Asian Studies, 9(2), 188-190. Gauld, R. (2007). [Review of the book Hong Kong’s health system: Reflections, perspectives and visions]. The China Journal, 58, 149-151. Gee, P., & Fountain, J. S. (2007). Party on? BZP party pills in New Zealand [Editorial]. The New Zealand Medical Journal, 120(1249). http://www.nzma.org.nz/journal/120-1249/2422/ Herbison, P. (2007). [Editorial comment]. Urology, 70(6), 1073.

Commissioned Report for External Body Cryer, C., Gulliver, P. J., Russell, D., & Davie, G. (2007). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators 1994-2005. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Dunedin, New Zealand: Injury Prevention Research Unit, University of Otago, 134p. Cryer, C., Gulliver, P. J., Russell, D., Davie, G. S., Langley, J., & Broughton, J. (2007). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators for Mäori; 1996-2005. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Dunedin, New Zealand: Injury Prevention Research Unit, University of Otago, 111p. Gulliver, P., Cryer, C., & Davie, G. (2007). A chartbook of the New Zealand Injury Prevention Strategy serious injury outcome indicators for children; 1994-2005. Commissioned by New Zealand Injury Prevention Strategy Secretariat, ACC. Dunedin, New Zealand: Injury Prevention Research Unit, University of Otago, 62p. Pearce, N., Dryson, E., Gander, P., Langley, J., & Wagstaffe, M. (2007). National profile of occupational health and safety in New Zealand: Report to the Minister of Labour. Commissioned by National Occupational Health and Safety Advisory Committee. Wellington, New Zealand: NOHSAC, 39p. Sneyd, M.J. (2007). Review of vitamin D, sun exposure and cancer report. Commissioned by Cancer Society of New Zealand, 7p. Sneyd, M.J. (2007). Epidemiology of melanoma in New Zealand. Commissioned by the Melanoma Reference Group of the New Zealand Guidelines Group, 19p. Sneyd, M.J. (2007). Survival from melanoma in New Zealand. Commissioned by the Melanoma Reference Group of the New Zealand Guidelines Group, 9p. Wilson, C. A., Walker, H., Button, C., & Gulliver, P. (2007). Off-road motorised vehicular injury in the Otago Region. Commissioned by Otago Motor Club Trust. Dunedin, New Zealand: Clothing and Textile Sciences/Human Performance Centre, University of Otago, 30p.

Creative Work Broughton, J. (2007). The Four Seasons of Aotearoa/New Zealand Devised for the Dunedin Heritage Festival 22 March 2007.

Working Paper; Discussion Paper; Technical Report Connor, J., Langley, J., & Cryer, C. (2007). International comparisons of injury: A compilation of reports to the New Zealand Injury Prevention Strategy Secretariat. Dunedin, New Zealand: Injury Prevention Research Unit, University of Otago. (pp. 1-54). Freeman, C., Quigg, R., Vass, E., & Broad, M. (2007). The Changing Geographies of Childrens Lives: A study of how children in Dunedin use their environment: Report on Research Findings. Dunedin, New Zealand: Department of Geography, University of Otago. (pp. 1-56). Jopson, J., & Reeder, T. (2007). An audit of Yellow Pages telephone directory listings of indoor tanning facilities in New Zealand, 1992-2006. Cancer Society of New Zeland Inc. Dunedin, New Zealand: Department of Preventive & Social Medicine, University of Otago. (pp. 1-19). Langley, J., Kypri, K., Cryer, C., & Davie, G. (2007). Developing valid indicatiors for alcohol-related injury in New Zealand. Dunedin, New Zealand: Injury Prevention Research Unit, University of Otago. (pp. 1-11). Richards, R. (2007). Climate and physical activity: A feasibility study. Cancer Society of New Zealand. Dunedin, New Zealand: University of Otago. (pp. 1-3). Wright, C. Y., Reeder, A. I., Gray, A., & Cox, B. (2007). Solar ultraviolet radiation exposure of New Zealand schoolchildren. Cancer Society of New Zealand Inc. Dunedin, New Zealand: Department of Preventive & Social Medicine, University of Otago. (pp. 1-123).

Booklet – Guidebook Greenfield, C., Archer, R., Bayes, C., Beatson, J., Chambers, J., Connell, G., Gray, W., Lingard, B., Quigg, R., et al. (2007) Outside is where we need to be: A guide to providing optimal outdoor environments in early childhood settings. (pp19). Auckland, New Zealand: Manukau Institute of Technology.

146 RESEARCH REPORT 2007/2008 Factsheet Gulliver, P. J. & Simpson, J. C. (2007). Causes of injury by age. Injury Prevention Research Unit Factsheet, 39. Dunedin, New Zealand. IPRU, University of Otago. Gulliver, P. J. & Simpson, J. C. (2007). Child injury: Deaths and hospitalisations. Injury Prevention Research Unit Factsheet, 40. Dunedin, New Zealand. IPRU, University of Otago. Gulliver, P. J. & Simpson, J. C. (2007). Injury as a leading cause of death and hospitalisation. Injury Prevention Research Unit Factsheet, 38. Dunedin New Zealand: IPRU, University of Dunedin

DUNEDIN SCHOOL OF MEDICNE DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Journal – Research Article Gale, C., Mullen, R. S., & Shue, L. (2007). Guidelines, process and ethics with the New Zealand Mental Health (compulsory assessment and treatment) Act: Striking a balance. BMC Psychiatry, 7(Suppl. 1), S102. Hannah, A. E., & Murachver, T. S. (2007). Gender preferential responses to speech. Journal of Language and Social Psychology, 26(3), 274-290. Harrison-Woolrych, M., Garcia-Quiroga, J., Ashton, J. A., & Herbison, P. P. (2007). Safety and usage of atypical antipsychotic medicines in children: A nationwide prospective cohort study. Drug Safety, 30(7), 569-579. Koenen, K. C., Moffitt, T. E., Poulton, R., Martin, J., & Caspi, A. (2007). Early childhood factors associated with the development of poat-traumatic stress disorder: Results from a longitudinal birth cohort. Psychological Medicine, 37, 181-192. Sadler, K., McGarrigle, C., Elam, G., Ssanyu-Sseruma, W., Davidson, O., Nichols, T., Mercey, D., Parry, J. & Fenton, K. Sexual behaviour and HIV infection in black-Africans in England: results from the Mayisha II survey of sexual attitudes and lifestyles. Sexually Transmitted Infections, (2007). 83; 523-529. Skegg, K. M., Nada-Raja, S., Paul, C. E., & Skegg, D. C. (2007). Body piercing, personality, and sexual behaviour. Archives of Sexual Behavior, 36, 47-54. Trevena, J., & Reeder, A. (2007). Perceptions of New Zealand adults about reducing their risk of getting cancer. The New Zealand Medical Journal, 120(1258). http://www.nzma.org.nz/journal/120-1258/2630/

Journal – Research Other Gale, C. (2007). Generalised anxiety disorder [Handbook]. BMJ Clinical Evidence, 340-341. Gale, C., & Davidson, O. (2007). Generalised anxiety disorder [Clinical Review]. BMJ, 334, 579-581. Gale, C., & Millichamp, C. J. (2007). Generalised anxiety disorder. BMJ Clinical Evidence.

Journal – Professional & Other Non-Research Articles Gale, C. (2007). Escitalopram 10 mg daily is more effective than paroxetine and placebo for generalised anxiety disorder [Commentary]. Evidence-Based Mental Health, 10, 45.

Commissioned Report Davidson, O. Behavioural prevention interventions in HIV. (2007). NAHIP Research Briefings. UCL: London.

DUNEDIN SCHOOL OF MEDICNE DEPARTMENT OF WOMEN’S AND CHILDREN’S HEALTH Obstetrics & Gynaecology

Journal – Research Article Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189. Dean, N. M., Ellis, G., Wilson, P. D., & Herbison, G. P. (2007). Laparoscopic colposuspension for urinary incontinence in women (Review). Cochrane Database of Systematic Reviews, 3(CD002239). http://www.mrw.interscience.wiley.com/ cochrane/clsysrev/articles/CD002239/frame.html Kerruish, N. J., Campbell-Stokes, P. L., Gray, A., Merriman, T. R., Robertson, S. P., & Taylor, B. J. (2007). Maternal psychological reaction to newborn genetic screening for type 1 diabetes. Pediatrics, 120(2), e324-e335. Lilford, R., Girling, A., Braunholtz, D., Gillett, W., Gordon, J., Brown, C. A., & Stevens, A. (2007). Cost-utility analysis when not everyone wants the treatment: Modeling split-choice bias. Medical Decision Making, 27, 21-26. Miller, D., & Jaye, C. (2007). GPs’ perception of their role in the identification and management of family violence. Family Practice, 24(2), 95-101.

Division of HEALTH SCIENCES 147 Nygaard, I., Bryant, C., Dowell, C., & Wilson, P. D. (2007). Lifestyle interventions for the treatment of urinary incontinence in adults (Protocol). Cochrane Database of Systematic Reviews, 1(CD003505). http://mrw.interscience.wiley.com/cochrane/ clsysrev/articles/CD003505/frame.html Paterson, H., Clifton, J., Miller, D., Ashton, J., & Harrison-Woolrych, M. (2007). Hair loss with use of the levonorgestrel intrauterine device. Contraception, 76, 306-309.

Journal – Research Other Devenish, C. (2007). Elder friendly clinics. O & G, 9(1), 11-12. Devenish, C. (2007). Preconception care. O & G, 9(4), 21-22. Evans, N., Hutchinson, J., Simpson, J. M., Donoghue, D., Darlow, B. A., Henderson-Smart, D., for the Australian and New Zealand Neonatal Network, including Austin, N., Broadbent, R., & Richardson, V. (2007). Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Archives of Disease in Childhood – Fetal and Neonatal Edition, 92, F34-F40.

Paediatrics & Child Health

Chapter in Book – Research Kerruish, N. J. (2007). New possibilities for newborn genetic screening: Screening for genetic susceptibility to common disease. In N. Page (Ed.), Genes, society and the future (Vol. 1) (pp. 295-327). Dunedin, New Zealand: Human Genome Research Project, University of Otago. Kerruish, N. J. (2007). Screening newborns for genetic susceptibility: What’s the harm? In B. M. Knoppers (Ed.), Genomics and public health: Legal and socio-ethical perspectives (pp. 21-44). Leiden, Netherlands: Martinus Nijhoff. Robertson, S. P., & Wilkie, A. O. M. (2007). Developmental disorders. In A. Wright & N. Hastie (Eds.), Genes and common diseases: Genetics in modern medicine (pp. 201-212). Cambridge University Press.

Chapter in Book – Textbook & Other Taylor, B. J. (2007). Sudden infant death syndrome and sudden unexpected death during sleep in infancy. In D. M. Roberton & M. South (Eds.), Practical paediatrics (6th ed.). (pp. 127-132). Edinburgh, Scotland: Churchill Livingstone.

Journal – Research Article Albano, L. M. J., Bertola, D. R., Barba, M. F., Valente, M., Robertson, S. P., & Kim, C. A. (2007). Phenotypic overlap in Melnick- Needles, serpentine fibula-polycystic kidney and Hajdu-Cheney syndromes: A clinical and molecular study in three patients. Clinical Dysmorphology, 16(1), 27-33. Baddock, S. A., Galland, B. C., Taylor, B. J., & Bolton, D. P. (2007). Sleep arrangements and behavior of bed-sharing families in the home setting. Pediatrics, 119, 200-207. Balakrishnan, K., Tordoff, J., Norris, P., & Reith, D. (2007). Establishing a baseline for the monitoring of medicines availability for children in the UK: 1998-2002. British Journal of Clinical Pharmacology, 63(1), 85-91. Bicknell, L. S., Farrington-Rock, C., Shafeghati, Y., Rump, P., Alanay, Y., Alembik, Y., Al-Madani, N., Firth, H., Karimi-Nejad, M. H., Kim, C. A., Leask, K., Maisenbacher, M., Moran, E., Pappas, J. G., Prontera, P., de Ravel, T., Fryns, J-P., Sweeney, E., Fryer, A., Unger, S., Wilson, L. C., Lachman, R. S., Rimoin, L., Cohn, D. H., Krakow, D., & Robertson, S. P. (2007). A molecular and clinical study of Larsen syndrome caused by mutations in FLNB. Journal of Medical Genetics, 44, 89-98. Broadbent, R. S. (2007). Recipient Twin Limb Ischemia with Postnatal Onset. Journal of Pediatrics, 150, 207-209. Carter, M. J., McGee, R. O., Taylor, B. J., & Williams, S. M. (2007). Health outcomes in adolescence: Associations with family, friends and school engagement. Journal of Adolescence, 30, 51-62. Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189. Dean, N. M., Ellis, G., Wilson, P. D., & Herbison, G. P. (2007). Laparoscopic colposuspension for urinary incontinence in women (Review). Cochrane Database of Systematic Reviews, 3(CD002239). http://www.mrw.interscience.wiley.com/ cochrane/clsysrev/articles/CD002239/frame.html Galland, B. C., Tan, E., & Taylor, B. J. (2007). Pulse transit time and blood pressure changes following auditory-evoked subcortical arousal and waking of infants. Sleep, 30(7), 891-897. Jenkins, Z. A., Hagar, W., Bowlus, C. L., Johansson, H. E., Harmatz, P., Vichinsky, E. P., & Theil, E. C. (2007). Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: Changes in iron regulatory protein, hepcidin, and ferritin expression. Pediatric Hematology and Oncology, 24, 237-243. Kerruish, N. J., Campbell-Stokes, P. L., Gray, A., Merriman, T. R., Robertson, S. P., & Taylor, B. J. (2007). Maternal psychological reaction to newborn genetic screening for type 1 diabetes. Pediatrics, 120(2), e324-e335. Mariño-Enríquez, A., Lapunzina, P., Robertson, S. P., & Rodríguez, J. I. (2007). Otopalatodigital syndrome type 2 in two siblings with a novel filamin A 629G>T mutation: Clinical, pathological, and molecular findings. American Journal of Medical Genetics Part A, 143A, 1120-1125.

148 RESEARCH REPORT 2007/2008 O’Brien, K. S., Hunter, J. A., & Banks, M. (2007). Implicit anti-fat bias in physical educators: Physical attributes, ideology and socialization. International Journal of Obesity, 31, 308-314. O’Brien, K. S., Venn, B. J., Perry, T., Green, T. J., Aitken, W., Bradshaw, A., & Thomson, R. (2007). Reasons for wanting to lose weight: Different strokes for different folks. Eating Behaviors, 8, 132-135. Reith, D. M., & Edmonds, L. K. (2007). Assessing the role of drugs in suicidal ideation and suicidality. CNS Drugs, 21(6), 463-472. Robertson, S. P. (2007). Otophalatodigital syndrome spectrum disorders: Otopalatodigital syndrome types 1 and 2, frontometaphyseal dysplasia and Melnick-Needles syndrome. European Journal of Human Genetics, 15, 3-9. Somerville, R. L., Grant, C. C., Grimwood, K., Murdoch, D., Graham, D., Jackson, P., Meates-Dennis, M-A., Nicholson, R. A., & Purvis, D. (2007). Infants hospitalised with pertussis: Estimating the true disease burden. Journal of Paediatrics and Child Health, 43, 617-622. Wilson, C., Kerruish, N. J., Wilcken, B., Wiltshire, E., & Webster, D. (2007). The failure to diagnose inborn errors of metabolism in New Zealand: The case for expanded newborn screening. The New Zealand Medical Journal, 120(1262). http://www.nzma.org.nz/journal/120-1262/2727/ Zacharias, M., De Silva, R. K., Hickling, J., Medlicott, N. J., & Reith, D. M. (2007). Comparative safety and efficacy of two high dose regimens of oral paracetamol in healthy adults undergoing third molar surgery under local anaesthesia. Anaesthesia and Intensive Care, 35(4), 544-549.

Journal – Research Other Broadbent, R. S. (2007). [Reply to letter to the editor On the pathogenesis of recipient twin limb ischemia]. The Journal of Pediatrics, 151(1), e4-e5. Evans, N., Hutchinson, J., Simpson, J. M., Donoghue, D., Darlow, B. A., Henderson-Smart, D., for the Australian and New Zealand Neonatal Network, including Austin, N., Broadbent, R., & Richardson, V. (2007). Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Archives of Disease in Childhood – Fetal and Neonatal Edition, 92, F34-F40.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF MEDICINE

Journal – Research Article Aldington, S., Williams, M., Nowitz, M., Weatherall, M., Pritchard, A., McNaughton, A., Robinson, G. M., & Beasley, R. (2007). Effects of cannabis on pulmonary structure, function and symptoms. Thorax, 62, 1058-1063. Burgess, C. D., Ingham, T., Woodbridge, M., Weatherall, M., & Nowitz, M. R. (2007). The use of antithrombotics in patients presenting with stroke and atrial fibrillation. Therapeutics and Clinical Risk Management, 3(3), 491-498. Dalbeth, N., Clark, B., McQueen, F., Doyle, A., & Taylor, W. (2007). Validation of a radiographic damage index in chronic gout. Arthritis Care and Research, 57(6), 1067-1073. Davis, P. F., Greenhill, N. S., Rowan, A. M., & Schollum, L. M. (2007). The safety of New Zealand bovine colostrum: Nutritional and physiological evaluation in rats. Food and Chemical Toxicology, 45, 229-236. Elder, D. E., Russell, L., Sheppard, D., Purdie, G. L., & Campbell, A. J. (2007). Car seat test for preterm infants: Comparison with polysomnography. Archives of Disease in Childhood – Fetal and Neonatal Edition, 92, F468-F472. Epton, M. J., Town, G. I., Ingham, T., Wickens, K. L., Fishwick, D., Crane, J., the New Zealand Asthma and Allergy Birth Cohort Study Group, including Duignan, M., Fitzharris, P., Kelly, R., Lampshire, P., Leadbitter, P., Nicholson, A., Pattemore, P. K., Siebers, R. W., Silvers, K. M., & Withell, K. A. (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7(26), 26. http://www.biomedcentral.com/1471- 2458/7/26 Erwin, E. A., Rönmark, E., Wickens, K. L., Perzanowski, M. S., Barry, D., Lundbäck, B., Crane, J., & Platts-Mills, T. A. E. (2007). Contribution of dust mite and cat specific IgE to total IgE: Relevance to asthma prevalence. Journal of Allergy and Clinical Immunology, 119, 359-365. Findlay, M., Sharples, K., Riley, G. A., Simpson, A., Ackland, S., Hall, K., Isaacs, R., Humm, G., & McKeage, M. J. (2007). Capecitabine and oral cyclophosphamide: A novel oral treatment combination for advanced cancer. Asia-Pacific Journal of Clinical Oncology, 3, 99-105. Gallagher, L. M., Crane, J., Fitzharris, P., & Bates, M. N. (2007). Occupational respiratory health of New Zealand horse trainers. International Archives of Occupational and Environmental Health, 80, 335-341. Hay-Smith, E. J. C., Siegert, R. J., Weatherall, M., & Abernethy, D. A. (2007). Bladder and bowel dysfunction in multiple sclerosis: A review of treatment effectiveness. Australian and New Zealand Continence Journal, 13(3), 81-89. Howden-Chapman, P. L., Matheson, A., Crane, J., Viggers, H. E., Cunningham, M., Blakely, T. A., Cunningham, C., Woodward, A., Saville-Smith, K., O’Dea, D., Kennedy, M., Baker, M. G., Waipara, N., Chapman, R., & Davie, G. S. (2007). Effect of insulating existing houses on health inequality: Cluster randomised study in the community. BMJ, 334, 460. http://www. bmj.com/cgi/content/full/334/7591/460 Lawson, B. R., Belkowski, S. M., Whitesides, J. F., Davis, P., & Lawson, J. W. (2007). Immunomodulation of murine collagen- induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus. BMC Complementary and Alternative Medicine, 7.

Division of HEALTH SCIENCES 149 Marsh, S., Aldington, S., Williams, M. V., Nowitz, M. R., Kingzett-Taylor, A., Weatherall, M., Shirtcliffe, P., McNaughton, A. A., Pritchard, A., & Beasley, R. (2007). Utility of lung density measurements in the diagnosis of emphysema. Respiratory Medicine, 101, 1512-1520. Marsh, S., Aldington, S., Williams, M. V., Weatherall, M., Robiony-Rogers, D., Jones, D., & Beasley, R. (2007). Pulmonary function testing in New Zealand: The use and importance of reference ranges. Respirology, 12, 367-374. Nam, H-S., Siebers, R. W., Lee, S-H., Kim, S-H., Lee, S-H., & Crane, J. (2007). Activated charcoal suppresses breeding of the house dust mite, Dermatophagoides Pteronyssinus, in culture. Journal of the Korean Academy of Medical Sciences, 22, 383- 385. Oldfield, K., Siebers, R. W., & Crane, J. (2007). Endotoxin and indoor allergen levels in kindergartens and daycare centres in Wellington, New Zealand. The New Zealand Medical Journal, 120(1248). http://www.nzma.org.nz/journal/120-1248/ Reeves, G., Wallis, R., Crowston, J. G., Small, K., & Wells, A. P. (2007). The effect of ICG on mitomycin C cytotoxicity in human tenon fibroblasts. Journal of Glaucoma, 16(5), 479-482. Robinson, G., Narasimhan, S., Weatherall, M., & Beasley, R. (2007). Hemochromatosis gene mutations, liver function tests and iron status in alcohol-dependent patients admitted for detoxification. Journal of Gastroenterology and Hepatology, 22, 852-854. Shirtcliffe, P., Weatherall, M., Marsh, S., Travers, J., Hansell, A., McNaughton, A., Aldington, S., Muellerova, H., & Beasley, R. (2007). COPD prevalence in a random population survey: A matter of definition. European Respiratory Journal, 30, 232-239. Siebers, R., Hayes, J., & Crane, J. (2007). Upper body clothing is a source of fungal beta-(1,3)-glucan exposure. Journal of Asthma, 44, 649-650. Smith, J. G., Harper, D. N., Gittings, D., & Abernethy, D. A. (2007). The effect of Parkinson’s disease on time estimation as a function of stimulus duration range and modality. Brain and Cognition, 64, 130-143. Steer, S., Abkevich, V., Gutin, A., Cordell, H. J., Gendall, K. L., Merriman, M. E., Rodger, R. A., Rowley, K. A., Chapman, P., Gow, P., Harrison, A. A., Highton, J., Jones, P. B. B., O’Donnell, J., Stamp, L., Fitzgerald, L., Iliev, D., Kouzmine, A., Tran, T., Skolnick, M. H., Timms, K. M., Lanchbury, J. S., & Merriman, T. R. (2007). Genomic DNA pooling for whole-genome association scans in complex disease: Empirical demonstration of efficacy in rheumatoid arthritis. Genes and Immunity, 8, 57-68. Stolarek, I. (2007). Procedural and examination skills of first-year house surgeons: A comparison of a simulation workshop versus 6 months of clinical ward experience alone. The New Zealand Medical Journal, 120(1253). http://www.nzma.org. nz/journal/120-1253/2516/ Stolarek, I. (2007). Procedural and examination skills of first-year postgraduate doctors do not improve with clinical experience alone. The New Zealand Medical Journal, 120(1253). http://www.nzma.org.nz/journal/120-1253/2515/ Travers, J., Marsh, S., Aldington, S., Williams, M., Shirtcliffe, P., Pritchard, A., Weatherall, M., & Beasley, R. (2007). Reference ranges for exhaled nitric oxide derived from a random community survey of adults. American Journal of Respiratory and Critical Care Medicine, 176, 238-242. Travers, J., Marsh, S., Caldwell, B., Williams, M., Aldington, S., Weatherall, M., Shirtcliffe, P., & Beasley, R. (2007). External validity of randomized controlled trials in COPD. Respiratory Medicine, 101, 1313-1320. Travers, J., Marsh, S., Williams, M., Weatherall, M., Caldwell, B., Shirtcliffe, P., Aldington, S., & Beasley, R. (2007). External validity of randomised controlled trials in asthma: To whom do the results of the trials apply? Thorax, 62, 219-223. Weatherall, M., Burgess, C. D., & Taylor, W. J. (2007). Open-label extension studies: Interpretation and statistical issues. International Journal of Pharmaceutical Medicine, 21(2), 115-120. Weinmayr, G., Weiland, S. K., Björkstén, B., Brunekreef, B., Büchele, G., Cookson, W. O. C., Garcia-Marcos, L., Gotua, M., Gratziou, C., van Hage, M., von Mutius, E., Riikjarv, M-A., Rzehak, P., Stein, R. T., Strachan, D. P., Tsanakas, J., Wickens, K. L., Wong, G. W., ISAAC Phase Three Study Group, & including Crane, J. (2007). Atopic sensitization and the international variation of asthma symptom prevalence in children. American Journal of Respiratory and Critical Care Medicine, 176, 565-574. Yuan, L., Ahn, I-S., & Davis, P. F. (2007). Inhibition of tyrosine phosphorylation of vascular endothelial growth factor receptors in human umbilical vein endothelial cells: A potent anti-angiogenic lipid-rich extract from shark. Journal of Medicinal Food, 10(4), 657-661.

Journal – Research Other Siebers, R. W., Parkes, A., Miller, J. D., & Crane, J. (2007). Effect of allergen-impermeable covers on beta-(1,3)-glucan content of pillows. Allergy, 62, 451-454.

150 RESEARCH REPORT 2007/2008 Journal – Professional & Other Non-Research Articles Caldwell, B., Beasley, R., Weatherall, M., & Metcalfe, S. (2007). Balancing the risks and benefits of celecoxib [Letter to the editor]. American Journal of Medicine, 120, e17. Cameron, C. R., & Burgess, C. D. (2007). Recurrent back pain and fevers [Diagnostic dilemmas]. Medical Journal of Australia, 186(4), 208-209. Griffiths, R. F., & Ellis, P. M. (2007). Visual conversion disorder in a harbor pilot leading to sudden loss of control of a large vessel [Case report]. Aviation, Space, and Environmental Medicine, 78(1), 59-62. Mann, S. (2007). Hypertension update. New Zealand Family Physician, 34(4), 270-273. Siebers, R., & Thornton, A. T. (2007). A new Editorial Board, a new journal prize and a revamped journal questionnaire. New Zealand Journal of Medical Laboratory Science, 61(1), 3. Judson, G., Bird, R., Poynter, T., Schroder, M., Robinson, G., Moriarty, H., Flewett, T., Bradford, P., Carter, H., et al. (2007, November). The nature, incidence and frequency of injecting behaviour amongst patients in lower North Island Methadone programmes. Verbal presentation at the Combined Australasian Professional Society on Alcohol and other Drugs and Cutting Edge Addiction Conference, Auckland, New Zealand. Tweed, M., & Wilkinson, T. (2007, July). A randomised trial of candidate instructions regarding EMCQ marking schemes. Verbal presentation at the Association for the Study of Medical Education Annual Scientific Meeting, Staffordshire, UK.

Rehabilitation Teaching and Research Unit

Chapter in Book – Research Hay-Smith, E. J. C., Dumoulin, C. L., & Herbison, P. (2007). Pelvic floor muscle training for urinary incontinence in women. In C. Webb & B. Roe (Eds.), Reviewing Research Evidence for Nursing Practice: Systematic Reviews (pp. 31-50). Oxford, UK: Blackwell.

Journal – Research Article Aldington, S., Williams, M., Nowitz, M., Weatherall, M., Pritchard, A., McNaughton, A., Robinson, G. M., & Beasley, R. (2007). Effects of cannabis on pulmonary structure, function and symptoms. Thorax, 62, 1058-1063. Beasley, R., Aldington, S., Weatherall, M., Robinson, G. M., & McHaffie, D. (2007). Oxygen therapy in myocardial infarction: An historical perspective. Journal of the Royal Society of Medicine, 100, 130-133. Burgess, C. D., Ingham, T., Woodbridge, M., Weatherall, M., & Nowitz, M. R. (2007). The use of antithrombotics in patients presenting with stroke and atrial fibrillation. Therapeutics and Clinical Risk Management, 3(3), 491-498. Charles, T., Quinn, D., Weatherall, M., Aldington, S., Beasley, R., & Holt, S. (2007). An audiovisual reminder function improves adherence with inhaled corticosteroid therapy in asthma. Journal of Allergy and Clinical Immunology, 119, 811-816. Crawford, C., Ryan, K., & Shipton, E. A. (2007). Exploring general practitioner identification and managment of psychosocial Yellow Flags in acute low back pain. The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/ journal/120-1254/2536/ Gladman, D. D., Inman, R. D., Cook, R. J., ..., Taylor, W. J., et al. (2007). International spondyloarthritis interobserver reliability exercise: The INSPIRE study: I. Assessment of spinal measures. Journal of Rheumatology, 34(8), 1733-1739. Gladman, D. D., Inman, R. D., Cook, R. J., Taylor, W. J., et al. (2007). International spondyloarthritis interobserver reliability exercise: The INSPIRE study: II. Assessment of peripheral joints, enthesitis, and dactylitis. Journal of Rheumatology, 34(8), 1740-1745. Gladman, D. D., Mease, P. J., Healy, P., Taylor, W. J., et al. (2007). Outcome measures in psoriatic arthritis. Journal of Rheumatology, 34(5), 1159-1166. Gladman, D. D., Mease, P. J., Strand, V., ..., Taylor, W. J., et al. (2007). Consensus on a core set of domains for psoriatic arthritis. Journal of Rheumatology, 34, 1167-1170. Harding, S. A., Din, J. N., Sarma, J., Jessop, A., Weatherall, M., Fox, K. A. A., & Newby, D. E. (2007). Flow cytometric analysis of circulating platelet-monocyte aggregates in whole blood: Methodological considerations. Journal of Thrombosis and Haemostasis, 98, 451-456. Hay-Smith, E. J. C., Ryan, K., & Dean, S. (2007). The silent, private exercise: Experiences of pelvic floor muscle training in a sample of women with stress urinary incontinence. Physiotherapy, 93, 53-61. Hay-Smith, E. J. C., Siegert, R. J., Weatherall, M., & Abernethy, D. A. (2007). Bladder and bowel dysfunction in multiple sclerosis: A review of treatment effectiveness. Australian and New Zealand Continence Journal, 13(3), 81-89. Helliwell, P. S., Porter, G. G., & Taylor, W. J. (2007). Polyarticular psoriatic arthritis is more like oligoarticular psoriatic arthritis, than rheumatoid arthritis. Annals of the Rheumatic Diseases, 66, 113-117. Lord, S., & Rochester, L. (2007). Walking in the real world: Concepts related to functional gait [Invited clinical commentary]. New Zealand Journal of Physiotherapy, 35(3), 126-130. Marsh, S., Aldington, S., Williams, M. V., Nowitz, M. R., Kingzett-Taylor, A., Weatherall, M., Shirtcliffe, P., McNaughton, A. A., Pritchard, A., & Beasley, R. (2007). Utility of lung density measurements in the diagnosis of emphysema. Respiratory Medicine, 101, 1512-1520. Marsh, S., Aldington, S., Williams, M. V., Weatherall, M., Robiony-Rogers, D., Jones, D., & Beasley, R. (2007). Pulmonary function testing in New Zealand: The use and importance of reference ranges. Respirology, 12, 367-374.

Division of HEALTH SCIENCES 151 Nabi, G., Cody, J. D., Ellis, G., Herbison, P., & Hay-Smith, J. (2007). Anticholinergic drugs versus placebo for overactive bladder syndrome in adults (Review). Cochrane Database of Systematic Reviews, 4, CD003781. Pickering, R., & Weatherall, M. (2007). The analysis of continuous outcomes in multi-centre trials with small centre sizes. Statistics in Medicine, 26, 5445-5456. Robinson, G., Narasimhan, S., Weatherall, M., & Beasley, R. (2007). Hemochromatosis gene mutations, liver function tests and iron status in alcohol-dependent patients admitted for detoxification. Journal of Gastroenterology and Hepatology, 22, 852-854. Schumacher, H. R., Taylor, W. J., Joseph-Ridge, N., Perez-Ruiz, F., Chen, L. X., Schlesinger, N., et al. (2007). Outcome evaluations in gout. Journal of Rheumatology, 34(6), 1381-1385. Shirtcliffe, P., Weatherall, M., Marsh, S., Travers, J., Hansell, A., McNaughton, A., Aldington, S., Muellerova, H., & Beasley, R. (2007). COPD prevalence in a random population survey: A matter of definition. European Respiratory Journal, 30, 232-239. Siegert, R. J., Ward, T., Levack, W. M. M., & McPherson, K. M. (2007). A Good Lives Model of clinical and community rehabilitation. Disability and Rehabilitation, 29(20-21), 1604-1615. Stamm, T. A., Nell, V., Mathis, M., Coenen, M., Aletaha, D., Cieza, A., Stucki, G., Taylor, W. J., Smolen, J. F., & Machold, K. P. (2007). Concepts important to patients with psoriatic arthritis are not adequately covered by standard measures of functioning. Arthritis Care and Research, 57(3), 487-494. Taylor, W. J., & McPherson, K. M. (2007). Using Rasch analysis to compare the psychometric properties of the Short Form 36 physical function score and the Health Assessment Questionnaire disability index in patients with psoriatic arthritis and rheumatoid arthritis. Arthritis Care and Research, 57(5), 723-729. Taylor, W. J., Schumacher, H. R., Singh, J. A., Grainger, R., & Dalbeth, N. (2007). Assessment of outcome in clinical trials of gout – A review of current measures. Rheumatology, 46, 1751-1756. Travers, J., Marsh, S., Aldington, S., Williams, M., Shirtcliffe, P., Pritchard, A., Weatherall, M., & Beasley, R. (2007). Reference ranges for exhaled nitric oxide derived from a random community survey of adults. American Journal of Respiratory and Critical Care Medicine, 176, 238-242. Travers, J., Marsh, S., Caldwell, B., Williams, M., Aldington, S., Weatherall, M., Shirtcliffe, P., & Beasley, R. (2007). External validity of randomized controlled trials in COPD. Respiratory Medicine, 101, 1313-1320. Travers, J., Marsh, S., Williams, M., Weatherall, M., Caldwell, B., Shirtcliffe, P., Aldington, S., & Beasley, R. (2007). External validity of randomised controlled trials in asthma: To whom do the results of the trials apply? Thorax, 62, 219-223. Vipond, N., Taylor, W., & Rider, M. (2007). Postoperative Splinting for Isolated Digital Nerve Injuries in the Hand. Journal of Hand Therapy, 20, 222-231. Weatherall, M., Burgess, C. D., & Taylor, W. J. (2007). Open-label extension studies: Interpretation and statistical issues. International Journal of Pharmaceutical Medicine, 21(2), 115-120.

Journal – Research Other Levack, W. (2007). Letters to the editor. Clinical Rehabilitation, 21, 284-285.

Journal – Professional & Other Non-Research Articles Caldwell, B., Beasley, R., Weatherall, M., & Metcalfe, S. (2007). Balancing the risks and benefits of celecoxib [Letter to the editor]. American Journal of Medicine, 120, e17. Mcpherson, K. M., & Siegert, R. J. (2007). Person-centred rehabilitation: Rhetoric or reality? [Editorial]. Disability and Rehabilitation, 29(20-21), 1551-1554. Taylor, W., Gladman, D., Helliwell, P., Marchesoni, A., Mease, P., & Mielants, H. (2007). [Reply to letter to the editor Are the classification criteria for poriatic arthritis better than existing criteria for diagnosing psoriatic arthritis? Comment on the Article by Taylor et al]. Arthritis and Rheumatism, 56(2), 700. Taylor, W. J., & Helliwell, P. S. (2007). Psoriatic arthritis is a joint-damaging disease – A call for action! Rheumatology, 46, 1747-1748.

UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Journal – Research Article Chand, A. L., Murray, A. S., Jones, R. L., Hannan, N. J., Salamonsen, L. A., & Rombauts, L. (2007). Laser capture microdissection and cDNA array analysis of endometrium identify CCL16 and CCL21 as epithelial-derived inflammatory mediators associated with endometriosis. Reproductive Biology and Endocrinology, 5. http://www.rbej.com/content/ pdf/1477-7827-5-18.pdf Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189.

152 RESEARCH REPORT 2007/2008 Fox, L., Sadowsky, J., Pringle, K. P., Kidd, A., Murdoch, J., Cole, D. E. C., & Wiltshire, E. (2007). Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant. Pediatrics, 120(5), e1350-e1354. Maharaj, D. (2007). Puerperal pyrexia: A review. Part I. Obstetrical and Gynecological Survey, 62(6), 393-399. Maharaj, D. (2007). Puerperal pyrexia: A review. Part II. Obstetrical and Gynecological Survey, 62(6), 400-406.

Journal – Research Other Wong, H. S., Zuccollo, J. M., Strand, L., Tait, J., & Pringle, K. C. (2007). The use of ultrasound in assessing the extent of myometrial involvement in partial placenta accreta [Letter to the editor]. Ultrasound in Obstetrics and Gynecology, 30, 227-230.

Journal – Professional & Other Non-Research Articles Wong, H. S., Cheung, Y. K., Strand, L., Carryer, P., Parker, S., Tait, J., & Pringle, K. C. (2007). Specific sonographic features of placenta accreta: Tissue interface disruption on gray-scale imaging and evidence of vessels crossing interface-disruption sites on Doppler imaging [Letter to the editor]. Ultrasound in Obstetrics and Gynecology, 29, 239-241.

UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF PAEDIATRICS AND CHILD HEALTH

Journal – Research Article Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189. Elder, D. E. (2007). Interpretation of anogenital findings in the living child: Implications for the paediatric forensic autopsy. Journal of Forensic and Legal Medicine, 14, 482-488. Elder, D. E., Russell, L., Sheppard, D., Purdie, G. L., & Campbell, A. J. (2007). Car seat test for preterm infants: Comparison with polysomnography. Archives of Disease in Childhood - Fetal and Neonatal Edition, 92, F468-F472. Fearon, D., Hesketh, E. L., Mitchell, A. E., & Grimwood, K. (2007). Mycoplasma pneumoniae infection complicated by pneumomediastinum and severe mucositis. Journal of Paediatrics and Child Health, 43(5), 403-405. Fox, L., Sadowsky, J., Pringle, K. P., Kidd, A., Murdoch, J., Cole, D. E. C., & Wiltshire, E. (2007). Neonatal hyperparathyroidism and pamidronate therapy in an extremely premature infant. Pediatrics, 120(5), e1350-e1354. Andermann, E., Gill, D., Farrell, K., Connolly, M., Stanley, T., et al. (2007). The spectrum of SCNIA-related infantile epileptic encephalopathies. Brain, 130, 843-852. McMorran, B. J., Patat, S. A. O., Carlin, J. B., Grimwood, K., Jones, A., Armstrong, D. S., et al. (2007). Novel neutrophil- derived proteins in bronchoalveolar lavage fluid indicate an exaggerated inflammatory response in pediatric cystic fibrosis patients. Clinical Chemistry, 53(10), 1782-1791. Peña, A., Wiltshire, E., Gent, R., Piotto, L., Hirte, C., & Couper, J. (2007). Folic acid does not improve endothelial function in obese children and adolescents. Diabetes Care, 30(8), 2122-2127. Sadleir, L. G., & Scheffer, I. (2007). Febrile seizures. BMJ, 334, 307-311. Somerville, R. L., Grant, C. C., Grimwood, K., Murdoch, D., Graham, D., Jackson, P., Meates-Dennis, M-A., Nicholson, R. A., & Purvis, D. (2007). Infants hospitalised with pertussis: Estimating the true disease burden. Journal of Paediatrics and Child Health, 43, 617-622.

Journal – Research Other Evans, N., Hutchinson, J., Simpson, J. M., Donoghue, D., Darlow, B. A., Henderson-Smart, D., for the Australian and New Zealand Neonatal Network, including Austin, N., Broadbent, R., & Richardson, V. (2007). Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Archives of Disease in Childhood – Fetal and Neonatal Edition, 92, F34-F40. Gallego, P. H., Wiltshire, E. J., & Donaghue, K. C. (2007). Identifying children at particular risk of long-term diabetes complications. Pediatric Diabetes, 8(Suppl. 6), 40-48. Redshaw, N., Wood, C., Rich, F., Grimwood, K., & Kirman, J. R. (2007). Human bocavirus in infants, New Zealand [Letter to the editor]. Emerging Infectious Diseases, 13(11), 1797-1799.

Journal – Professional & Other Non-Research Articles Grimwood, K., & Buttery, J. P. (2007). Clinical update: Rotavirus gastroenteritis and its prevention [Comment]. The Lancet, 370, 302-304.

Division of HEALTH SCIENCES 153 UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF PATHOLOGY AND MOLECULAR MEDICINE

Edited Book – Research Delahunt, B. (Ed.). (2007). Wellington Medical Research Foundation: Research review 2007. Wellington, New Zealand: WMRF, 43p.

Chapter in Book – Research Gellen, L. S., Wall-Manning, G. M., & Sissons, C. H. (2007). Checkerboard DNA-DNA hybridization technology using digoxigenin detection. In E, Hilario & J, Mackay (Eds.), Methods in Molecular Biology, Volume 353: Protocols for Nucleic Acid Analysis by Nonradioactive Probes (2nd ed.). (pp. 39-67). Totowa, NJ: Humana Press.

Journal – Research Article Aldington, S., Williams, M., Nowitz, M., Weatherall, M., Pritchard, A., McNaughton, A., Robinson, G. M., & Beasley, R. (2007). Effects of cannabis on pulmonary structure, function and symptoms. Thorax, 62, 1058-1063. Bäckström, B. T., Brockelbank, J. A., & Rehm, B. H. (2007). Recombinant Escherichia coli produces tailor-made biopolyester granules for applications in fluorescence activated cell sorting: Functional display of the mouse interleukin-2 and myelin oligodendrocyte glycoprotein. BMC Biotechnology, 7(3). http://www.biomedcentral.com/content/pdf/1472-6750-7-3.pdf Beasley, R., Aldington, S., & Robinson, G. M. (2007). Is it time to change the approach to oxygen therapy in the breathless patient? Thorax, 62, 840-841. Braye, K., Harwood, T., Inder, R., Beasley, R., & Robinson, G. M. (2007). Poppy seed tea and opiate abuse in New Zealand. Drug and Alcohol Review, 26(2), 215-219. Brunelli, M., Gobbo, S., Cossu-Rocca, P., Cheng, L., Hes, O., Delahunt, B., Pea, M., Bonetti, F., Mina, M. M., Ficarra, V., Chilosi, M., Eble, J. N., Menestrina, F., & Martignoni, G. (2007). Chromosomal gains in the sarcomatoid transformation of chromophobe renal cell carcinoma. Modern Pathology, 20, 303-309. Delahunt, B., Bethwaite, P. B., McCredie, M. R., & Nacey, J. N. (2007). The evolution of collagen expression in sarcomatoid renal cell carcinoma. Human Pathology, 38, 1372-1377. Delahunt, B., Bethwaite, P. B., & Nacey, J. N. (2007). Outcome prediction for renal cell carcinoma: Evaluation of prognostic factors for tumours divided according to histological subtype. Pathology, 39(5), 459-465. Delahunt, B., Sika-Paotonu, D., Bethwaite, P. B., McCredie, M. R., Martignoni, G., Eble, J., & Jordan, T. W. (2007). Fuhrman grading is not appropriate for chromophobe renal cell carcinoma. American Journal of Surgical Pathology, 31(6), 957-960. Filoche, S. K., Coleman, M. J., Angker, L., & Sissons, C. H. (2007). A fluorescence assay to determine the viable biomass of microcosm dental plaque biofilms. Journal Microbiol Methods, 69(3), 489-496. Filoche, S. K., Soma, K. J., & Sissons, C. H. (2007). Caries-related plaque microcosm biofilms development in microplates. Oral Microbiology and Immunology, 22(2), 73-79. Flamme, A. C., Harvie, M., Kenwright, D., Cameron, K., Rawlence, N., Low, Y. S., & McKenzie, S. K. (2007). Chronic exposure to schistosome eggs reduces serum cholesterol but has no effect on atherosclerotic lesion development. Parasite Immunology, 29, 259-266. Ganly, P. S., Hanrahan, V., Baker, B., & Romeril, K. (2007). Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. American Journal of Hematology, 82, 80-82. Gupta, R. K. (2007). Needle aspiration cytodiagnosis of the breast with abundant acellular calcific material mimicking soft tissue calcinosis. Acta Cytologica, 51, 33-36. Gupta, R. K. (2007). Needle aspiration cytology and immunohistologic findings in a case of leiomyosarcoma of the breast. Diagnostic Cytopathology, 35(4), 254-256. Hine, P. M., Engelsma, M. Y., & Wakefield, S. J. (2007). Ultrastructure of sporulation in Haplosporidium armoricanum. Diseases of Aquatic Organisms, 77(3), 225-233. Korn, T., Reddy, J., Gao, W., Bettelli, E., Awasthi, A., Petersen, T. R., & Bäckström, B. T. (2007). Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nature Medicine, 13(4), 423-431. Lamb, D. S., Bupha-Intr, O., Bethwaite, P., Murray, J., Nacey, J.N., Russell, G.R., and Delahunt, B,. (2008). Prostate Cancer: Are ethnic minorities disadvantaged? Anticancer Research, 28, 3891-3894. Lamb, D. S., Slaney, D., Smart, R., Nacey, J. N., Russell, G., Scott, B., Johnson, C. A., Adams, J. D., Moran, S., & Delahunt, B. (2007). Prostate cancer: The new evidence base fo diagnosis and treatment. Pathology, 39(6), 537-544. Matthews, K. E., Karabeg, A., Roberts, J. M., Saeland, S., Dekan, G., Epstein, M. M., & Ronchese, F. (2007). Long-term desposition of inhaled antigen in lung resident CD11b-CD11c+ cells. American Journal of Respiratory Cell and Molecular Biology, 36(4), 435-441. Matthews, K., Qin, J. S., Yang, J., Hermans, I. F., Palmowski, M. J., Cerundolo, V., & Ronchese, F. (2007). Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cells help during primary CD8+ T cell responses1. Journal of Immunology, 179, 5738-5747. Palmer, D., Lallu, S., Matheson, P., Bethwaite, P. B., & Tompson, K. (2007). Karyomegalic interstitial nephritis: A pitfall in urine cytology. Diagnostic Cytopathology, 35(3), 179-182. Petersen, T. R., Lata, R., Spittle, E., & Bäckström, B. T. (2007). A chimeric TCR-beta chain confers increased susceptibility to EAE. Molecular Immunology, 44, 3473-3481.

154 RESEARCH REPORT 2007/2008 Priest, P., Sadler, L., Peters, J., Crengle, S., Bethwaite, P. B., Medley, G., & Jackson, R. (2007). Pathways to diagnosis of cervical cancer: Screening history, delay in follow up, and smear reading. BJOG: An International Journal of Obstetrics & Gynaecology, 114, 398-407. Robinson, G., Morreau, J., Leighton, M., & Beasley, R. (2007). New hospital consultant: Surviving a difficult period. The New Zealand Medical Journal, 120(1259). Sissons, C. H., Anderson, S., Wong, L., Coleman, M. J., & White, D. C. (2007). Microbiota of plaque microcosm biofilms: Effect of three times daily sucrose pulses in different simulated oral environments. Caries Research, 41, 413-422. Sladek, R. E. J., Filoche, S. K., Sissons, C. H., & Stoffels, E. (2007). Treatment of Streptococcus mutans biofilms with a nonthermal atmospheric plasma. Letters in Applied Microbiology, 45, 318-323. Watt, V., Ronchese, F., & Ritchie, D. S. (2007). Resting B cells suppress tumor immunity via an MHC class-II dependent mechanism. Journal of Immunotherapy, 30(3), 323-332. Wong, L., & Sissons, C. H. (2007). Human dental plaque microcosm biofilms: Effect of nutrient variation on calcium phosphate deposition and growth. Archives of Oral Biology, 52, 280-289.

Journal – Professional & Other Non-Research Articles Dixon, J. W. (2007). Folic acid and neural tube defects in New Zealand: A cautionary tale? The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/journal/120-1254/2533/ Lowry, R. B., Baker, E., Dixon, J., & Hinton, L. (2007). Familial mental retardation due to a cryptic subtelomeric translocation -del 14qter and dup 9qter (the Anyon phenotype). Clinical Dysmorphology, 16, 223-229.

UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF PRIMARY HEALTH CARE AND GENERAL PRACTICE

Journal – Research Article Dew, K., Morgan, S., Dowell, A., McLeod, D., Bushnell, J., & Collings, S. D. (2007). ‘It puts things out of your control’: Fear of consequences as a barrier to patient disclosure of mental health issues to general practitioners. Sociology of Health & Illness, 29(7), 1-16. Dowell, A., Macdonald, L., Stubbe, M., Plumridge, E., & Dew, K. (2007). Clinicians at work: What can we learn from interactions in the consultation? New Zealand Family Physician, 34(5), 345-350. Elley, C. R., Robertson, M. C., Kerse, N. M., Garrett, S., McKinlay, E., Lawton, B., Moriarty, H., & Campbell, A. J. (2007). Falls Assessment Clinical Trial (FACT): Design, interventions, recruitment strategies and participant characteristics. BMC Public Health, 7. http://www.biomedcentral.com/1471-2458/7/185 Hyslop, B. (2007). Prolongation of the QT interval during methadone use: How important is dose? New Zealand Medical Student Journal, 6, 4-7. Kumar, K. K., & Moriarty, H. J. (2007). Is bone health in the ‘too hard’ basket? New Zealand Family Physician, 34(2), 94-100. McKinlay, E., & McBain, L. (2007). Evaluation of the Palliative Care Partnership: A New Zealand solution to the provision of integrated palliative care. The New Zealand Medical Journal, 120(1263). http://www.nzma.org.nz/journal/120-1263/2745/ Perera, R., Dowell, T., Crampton, P., & Kearns, R. (2007). Panning for gold: An evidence-based tool for assessment of performance indicators in primary health care. Health Policy, 80, 314-327. Pullon, S., & Lum, R. (2007). Clinical teaching capacity in New Zealand general practice. The New Zealand Medical Journal, 121(1268). http://www.nzma.org.nz/journal/121-1268/2895/ Rose, S. B., Elley, C. R., Lawton, B. A., & Dowell, A. C. (2007). A single question reliably identifies physically inactive women in primary care. The New Zealand Medical Journal, 121(1268). http://www.nzma.org.nz/journal/121-1268/2897/ Rose, S. B., Lawton, B. A., Bromhead, C., MacDonald, E. J., & Lund, K. A. (2007). Self-obtained vaginal swabs for PCR chlamydia testing: A practical alternative. Australian and New Zealand Journal of Obstetrics and Gynaecology, 47, 415-418. Rose, S. B., Lawton, B. A., Elley, C. R., Dowell, A. C., & Fenton, A. J. (2007). The ‘Women’s Lifestyle Study’, 2-year randomized controlled trial of physical activity counselling in primary health care: Rationale and study design. BMC Public Health, 7. http://www.biomedcentral.com/1471-2458/7/166 Vickers, M. R., MacLennan, A. H., Lawton, B., Ford, D., Martin, J., Meredith, S. K., DeStavola, B. L., Rose, S., Dowell, A., Wilkes, H. C., Darbyshire, J. H., Meade, T. W., & for the WISDOM team (2007). Main morbidities recorded in the women’s international study of long duration oestrogen after menopause (WISDOM): A randomised controlled trial of hormone replacement therapy in postmenopausal women. BMJ, 335. http://www.bmj.com/cgi/content/full/335/7613/239

Journal – Research Other Garrett, S., Dowell, T., Bos, V., Collings, S., McBain, L., & McKinlay, E. (2007). The challenge of improving access to mental health services within a primary care setting. New Zealand Family Physician, 34(1), 25-29. Kumar, K. K., & Moriarty, H. J. (2007). Can we make a difference? Bone Alert, (February), 2-3. McKinlay, E., & Pullon, S. (2007). Interprofessional learning: The solution to collaborative practice in primary care. Kai Tiaki Nursing New Zealand, 13(10), 16-18. Moriarty, H. (2007). Adding reality to clinical skills training: A defining point. Focus on Health Professional Education: A Multi-Disciplinary Journal, 9(3), 92-95.

Division of HEALTH SCIENCES 155 Moriarty, H. J., & Mao, P. (2007). Doin’ the 12-step: What health professionals can gain from this. New Zealand Family Physician, 34(5), 368-370. Pullon, S. (2006). Education for general practice: Where are we going in the next fifteen years? New Zealand Family Physician, 33(6), 368-374. Pullon, S. (2007). A fundamental principle of primary health care and an essential prerequisite for effective management of chronic conditions. New Zealand Family Physician, 34(5), 318-321. Rose, S. B. (2007). Pain and heavy bleeding with intrauterine contraceptive devices. BMJ, 335, 410-411.

Journal – Professional & Other Non-Research Articles Dowell, T., & Turner, N. (2007). New Zealand: The urgent need to focus on child health? New Zealand Family Physician, 34(3), 152-157. Gray, B. (2007). English language difficulties at general practices in Auckland, New Zealand: A major limitation to good practice [Editorial]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2777/ Gray, B. (2007). Hand washing [Letter]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/ journal/120-1266/2846/ McKinlay, E. (2007). Thinking beyond care plus: The work of primary health care nurses in chronic conditions programmes. New Zealand Family Physician, 34(5), 322-327. McKinlay, E. (2007). Understanding quality in health care. Kai Tiaka: Nursing New Zealand, 13(2), 2. Moriarty, H. (2007). [Review of the article Access to stroke care units in Australian public hospitals: Facts and temporal progress]. New Zealand Family Physician, 34(1), 61. Moriarty, H. (2007). [Review of the article Anger in palliative care: A clinical approach]. New Zealand Family Physician, 34(2), 142-143. Moriarty, H. (2007). [Review of the article A pilot study using the internet to study patterns of party drug use: Processes, findings and limitations]. New Zealand Family Physician, 34(3), 216. Moriarty, H. (2007). [Review of the article A review of the efficacy and effectiveness of harm reduction strategies for alcohol, tobacco and illicit drugs]. New Zealand Family Physician, 34(2), 132. Moriarty, H. (2007). [Review of the article Bronchiectasis]. New Zealand Family Physician, 34(1), 69. Moriarty, H. (2007). [Review of the article Circuit breakers for addiction]. New Zealand Family Physician, 34(4), 297. Moriarty, H. (2007). [Review of the article Continuing professional development for rural physicians: An oxymoron or just non-existent?]. New Zealand Family Physician, 34(1), 62. Moriarty, H. (2007). [Review of the article Effect of chronic diseases and associated psychological distress on health-related quality of life]. New Zealand Family Physician, 34(2), 145. Moriarty, H. (2007). [Review of the article Fluid skills: Drinking games and alcohol consumption among Australian university students]. New Zealand Family Physician, 34(6), 452. Moriarty, H. (2007). [Review of the article Global use of alcohol, drugs and tobacco]. New Zealand Family Physician, 34(2), 132. Moriarty, H. (2007). [Review of the article Hepatitis B immunity in a population of drug and alcohol users]. New Zealand Family Physician, 34(5), 376. Moriarty, H. (2007). [Review of the article Irritable bowel syndrome]. New Zealand Family Physician, 34(1), 62-63. Moriarty, H. (2007). [Review of the article Is Australia ‘fair dinkum’ about drug education in schools?]. New Zealand Family Physician, 34(5), 374. Moriarty, H. (2007). [Review of the article Legal piperazine-containing party pills: A new trend in substance misuse]. New Zealand Family Physician, 34(4), 297. Moriarty, H. (2007). [Review of the article Medical aspects of fitness to drive. What do public hospital doctors know and think?]. New Zealand Family Physician, 34(4), 303. Moriarty, H. (2007). [Review of the article Non-invasive computed tomography angiography in the assessment of coronary stent patency: An Australian experience]. New Zealand Family Physician, 34(4), 298. Moriarty, H. (2007). [Review of the article Patients with acute myocardial infarction have an inaccurate understanding of their risk of a future cardiac event]. New Zealand Family Physician, 34(1), 59. Moriarty, H. (2007). [Review of the article Poppy seed tea and opiate abuse in New Zealand]. New Zealand Family Physician, 34(3), 216. Moriarty, H. (2007). [Review of the article Pre-operative screening for excessive alcohol consumption among patients scheduled for elective surgery]. New Zealand Family Physician, 34(3), 215-216. Moriarty, H. (2007). [Review of the article Public opinion on needle and syringe programmes: Avoiding assumptions for policy and practice]. New Zealand Family Physician, 34(5), 374. Moriarty, H. (2007). [Review of the article Roadside drug testing: Unanswered questions and future challenges]. New Zealand Family Physician, 34(3), 215. Moriarty, H. (2007). [Review of the article Sudden cardiac death in the young: A clinical genetic approach]. New Zealand Family Physician, 34(2), 134. Moriarty, H. (2007). [Review of the article Supervised injecting facilities: How much evidence is enough?]. New Zealand Family Physician, 34(5), 374. Moriarty, H. (2007). [Review of the article The efficacy of diversion and after care strategies for adult drug-involved offenders: A summary and methodological review of the outcome literature]. New Zealand Family Physician, 34(5), 374.

156 RESEARCH REPORT 2007/2008 Moriarty, H. (2007). [Review of the article Time for a medical educational change in time]. New Zealand Family Physician, 34(1), 62. Moriarty, H. (2007). [Review of the article Young people with chronic illness: The approach to transition]. New Zealand Family Physician, 34(6), 451. Moriarty, H. (2007). Student researchers make their mark at WSMHS. Addiction Treatment Research News, 11(1), 4-5. Pullon, S. (2007). A postscript to ‘Professional probity post-Fernando: A terrible beauty is born’ [Reader write]. New Zealand Family Physician, 34(6), 390-391. Pullon, S., & McKinlay, E. (2007). Interprofessional learning: The solution to collaborative practice in primary care. New Zealand Family Physician, 34(6), 404-408. Webber, K. (2007). Poor souls: Alcoholics Anonymous experience. New Zealand Medical Student Journal, 6, 22.

Commissioned Report for External Body Dowell, T., Garrett, S., Collings, S., McBain, L., McKinlay, E., & Stanley, J. (2007). Primary mental health initiatives evaluation: Interim report. Commissioned by Ministry of Health. Wellington, New Zealand: Department of Primary Health Care & General Practice, University of Otago, 242p. http://www.wnmeds.ac.nz/academic/gp/mentalhealth/ indexoctoberinterimreport.html.

UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Chapter in Book – Research Ellis, P. M. (2007). What causes mental illness? In S. Bloch & B. S. Singh (Eds.), Foundations of Clinical Psychiatry (Third ed.). (pp. 47-68). Melbourne University Press. Wells, J. E., Oakley Browne, M. A., & Scott, K. M. (2006). Executive summary. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. xxi-xxviii). Wellington, New Zealand: Alcohol Advisory Council of New Zealand.

Chapter in Book – Textbook & Other MacDonald, J., & O’Connor, K. (2007). Doctor’s health. In I. St George (Ed.), Cole’s medical practice in New Zealand (pp. 117- 125). Wellington, New Zealand: Medical Council of New Zealand.

Journal – Research Article Barnfield, T. V., Mathieson, F. M., & Beaumont, G. R. (2007). Assessing the development of competence during postgraduate cognitive-behavioral therapy training. Journal of Cognitive Psychotherapy: An International Quarterly, 21(2), 140-147. Beautrais, A., Fergusson, D., Coggan, C., Collings, C., Doughty, C., Ellis, P., Hatcher, S., Horwood, J., Merry, S., Mulder, R., Poulton, R., & Surgenor, L. (2007). Effective strategies for suicide prevention in New Zealand: A review of the evidence. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2459/ Demyttenaere, K., Bruffaerts, R., Lee, S., ..., Scott, K. M., et al. (2007). Mental disorders among persons with chronic back or neck pain: Results from the world mental health surveys. Pain, 129, 332-342. Dew, K., Morgan, S., Dowell, A., McLeod, D., Bushnell, J., & Collings, S. D. (2007). ‘It puts things out of your control’: Fear of consequences as a barrier to patient disclosure of mental health issues to general practitioners. Sociology of Health & Illness, 29(7), 1-16. Dronsfield, A. T., & Ellis, P. M. (2007). Cocaine: A short trip in time. Education in Chemistry, (September), 142-146. Dronsfield, A. T., & Ellis, P. M. (2007). Phenols in medicine. Education in Chemistry, (January), 21-22. Dronsfield, A. T., Ellis, P. M., & Pooley, K. (2007). Early pain-free days. Education in Chemistry, (November), 183-186. Ormel, J., Von Korff, M., Burger, H., Scott, K., Demyttenaere, K., Huang, Y-q., Posada-Villa, J., Lepine, J. P., Angermeyer, M. C., Levinson, D., de Girolamo, G., Kawakami, N., et al. (2007). Mental disorders among persons with heart disease: Results from World Mental Health surveys. General Hospital Psychiatry, 29, 325-334. Scott, K. M., Bruffaerts, R., Tsang, A., Ormel, J., Alonso, J., Angermeyer, M. C., Benjet, C., de Girolamo, G., de Graaf, R., Gasquet, I., Gureje, O., Haro, J. M., et al. (2007). Depression: Anxiety relationships with chronic physical conditions: Results from the World Health Surveys. Journal of Affective Disorders, 103, 113-120. Scott, K. M., Von Korff, M., Ormel, J., Zhang, M., Bruffaerts, R., Alonso, J., Kessler, R. C., Tachimori, H., Karam, E. G., Levinson, D., Bromet, E. J., Posada-Villa, J., et al. (2007). Mental disorders among adults with asthma: Results from the World Mental Health Surveys. General Hospital Psychiatry, 29, 123-133. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). Medical student characteristics associated with time in study: Is spending more time always a good thing? Medical Teacher, 29, 106-110. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). What is the educational impact of standards-based assessment in a medical degree? Medical Education, 41, 565-572.

Division of HEALTH SCIENCES 157 Journal – Professional & Other Non-Research Articles Burgess-Manning, J. (2007). Bringing two worlds together: A collaborative interview with JoEllen Patterson. Australian and New Zealand Journal of Family Therapy, 28(1), 38-43. Griffiths, R. F., & Ellis, P. M. (2007). Visual conversion disorder in a harbor pilot leading to sudden loss of control of a large vessel [Case report]. Aviation, Space, and Environmental Medicine, 78(1), 59-62.

UNIVERSITY OF OTAGO WELLINGTON DEPARTMENT OF PUBLIC HEALth

Authored Book – Research Broom, D., Deed, B., Dew, K. P., Durie, M., Germov, J., Kirkman, A., Macdonald, J., Moon, P., Park, J., Turner, B., & Walker, S. (2007). Health in the context of Aotearoa New Zealand. Melbourne, Australia: Oxford University Press, 388p.

Chapter in Book – Research Cormack, D. (2007). The Mäori population. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 11-20). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Cormack, D. M., Purdie, G. L., & Robson, B. H. (2007). Cancer. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years (pp. 103-119). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Curtis, E., Harwood, M., & Riddell, T. (2007). Cardiovascular disease. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 141-158). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Dew, K. P., & Carroll, P. (2007). Public health and CAM: Exploring overlap, contrast and dissonance. In J. Adams (Ed.), Researching complementary and alternative medicine (pp. 117-132). Oxon, UK: Routledge. Harris, R., Purdie, G., Robson, B. H., Wright, C. S., Zhang, J., & Baker, M. G. (2007). Estimating Mäori hospitalisations and cancer registrations. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000- 2005 (pp. 249-259). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Harwood, M., & Tipene-Leach, D. (2007). Diabetes. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 161-167). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Koopu, P., & Keefe-Ormsby, V. (2007). Oral Health - Oranga Niho. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 181-187). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Paine, S-J., Harris, R. B., & Mihaere, K. M. (2007). Sleep Problems. In R. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 199-207). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Purdie, G. L., & Robson, B. H. (2007). Mortality. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 33-61). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Reid, P., & Robson, B. (2007). Understanding health inequities. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 3-9). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Robson, B. H., Cormack, D. M., & Cram, F. (2007). Social and economic indicators. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 21-32). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago. Robson, B. H., Robson, C., Harris, R. B., & Purdie, G. L. (2007). Hospitalisations. In B. Robson & R. Harris (Eds.), Hauora: Mäori standards of health IV: A study of the years 2000-2005 (pp. 63-101). Wellington, New Zealand: Te Röpü Rangahau Hauora a Eru Pömare, University of Otago.

Journal – Research Article Ali, A., & Howden-Chapman, P. (2007). Maternity services and the role of the traditional birth attendant, bidan kampung, in rural Malaysia. Journal of Public Health Management and Practice, 13(3), 278-286. Asghar, M. N., Young, J., & Dew, K. P. (2007). Poster campaigns: Are they wasted effort? New Zealand Pharmacy, 27(7), 11-13. Baker, M. G., Sneyd, E., & Wilson, N. A. (2007). Is the major increase in notified campylobacteriosis in New Zealand real? Epidemiology and Infection, 135, 163-170. Baker, M. G., Thornley, C. N., Lopez, L. D., Garrett, N. K., & Nicol, C. M. (2007). A recurring salmonellosis epidemic in New Zealand linked to contact with sheep. Epidemiology and Infection, 135, 76-83. Baker, M., & Wilson, N. (2007). Chicken meat is clearly the most important source of human Campylobacter infection in New Zealand. New Zealand Journal of Medical Laboratory Science, 61(2), 44-47. Bauman, A., O’Hara, L., Signa, L., Smith, B., Ritchie, J., Parker, E., & Rissel, C. (2007). A perspective on changes in values in the profession of health promotion. Health Promotion Journal of Australia, 18(1), 3-6.

158 RESEARCH REPORT 2007/2008 Beautrais, A., Fergusson, D., Coggan, C., Collings, C., Doughty, C., Ellis, P., Hatcher, S., Horwood, J., Merry, S., Mulder, R., Poulton, R., & Surgenor, L. (2007). Effective strategies for suicide prevention in New Zealand: A review of the evidence. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2459/ Bindman, A. B., Forrest, C. B., Britt, H., Crampton, P., & Majeed, A. (2007). Diagnostic scope of and exposure to primary care physicians in Australia, New Zealand, and the United States: Cross sectional analysis of results from three national surveys. British Medical Journal, 334, 1261-1266. Brant, A. (2007). Baker’s asthma. Current Opinion in Allergy and Clinical Immunology, 7(2), 152-155. Cazelles, B., Chavez, M., de Magny, G. C., Guégan, J. -F., & Hales, S. (2007). Time-dependent spectral analysis of epidemiological time-series with wavelets. Journal of the Royal Society Interface, 4(15), 625-636. Crampton, P., Jatrana, S., Lay-Yee, R., & Davis, P. (2007). Exposure to primary medical care in New Zealand: Number and duration of general practitioner visits. The New Zealand Medical Journal, 120(1256). http://www.nzma.org.nz/ journal/120-1256/2582/ Crampton, P., Lay-Yee, R., Patrick, D., Davis, P., & Raymont, A. (2007). Comparative study of electronic pilot and paper data collection methods in a survey of general practice consultations. Healthcare Review Online, 11(1). http://www.hinz.org. nz/journal-pdf/959 Davie, G. S., Baker, M. G., Hales, S., & Carlin, J. B. (2007). Trends and determinants of excess winter mortality in New Zealand: 1980 to 2000. BMC Public Health, 7. http://www.biomedcentral.com/1471-2458/7/263 Dew, K. (2007). A health researcher’s guide to qualitative methodologies. Australian and New Zealand Journal of Public Health, 31(5), 433-437. Dew, K. (2007). Public health and the cult of humanity: A neglected Durkheimian concept. Sociology of Health & Illness, 29(1), 100-114. Dew, K., Morgan, S., Dowell, A., McLeod, D., Bushnell, J., & Collings, S. D. (2007). ‘It puts things out of your control’: Fear of consequences as a barrier to patient disclosure of mental health issues to general practitioners. Sociology of Health & Illness, 29(7), 1-16. Dowell, A., Macdonald, L., Stubbe, M., Plumridge, E., & Dew, K. (2007). Clinicians at work: What can we learn from interactions in the consultation? New Zealand Family Physician, 34(5), 345-350. Edwards, R., McElduff, P., Jenner, D., Heller, R. F., & Langley, J. (2007). Smoking, smoking cessation, and use of smoking cessation aids and support services in South Derbyshire, England. Public Health, 121, 321-332. Elder, D. E., Russell, L., Sheppard, D., Purdie, G. L., & Campbell, A. J. (2007). Car seat test for preterm infants: Comparison with polysomnography. Archives of Disease in Childhood - Fetal and Neonatal Edition, 92, F468-F472. Fawcett, J., & Blakely, T. (2007). Cancer is overtaking cardiovascular disease as the main driver of socioeconomic inequalities in mortality: New Zealand (1981-99). Journal of Epidemiology and Community Health, 61, 59-66. Fergusson, D. M., Horwood, L. J., Boden, J. M., & Jenkin, G. (2007). Childhood social disadvantage and smoking in adulthood: Results of a 25-year longitudinal study. Addiction, 102(3), 475-482. Garrett, N., Devane, M. L., Hudson, J. A., Nicol, C., Ball, A., Klena, J. D., Scholes, P., Baker, M. G., Gilpin, B. J., & Savill, M. G. (2007). Statistical comparison of Campylobacter jejuni subtypes from human cases and environmental sources. Journal of Applied Microbiology, 103, 2113-2121. Hales, S., Baker, M., Howden-Chapman, P., Menne, B., Woodruff, R., & Woodward, A. (2007). Implications of global climate change for housing, human settlements and public health. Reviews on Environmental Health, 22(4), 295-302. Harris, R., Robson, B., Curtis, E., Purdie, G. L., Cormack, D. M., & Reid, P. (2007). Mäori and non-Mäori differences in caesarean section rates: A national review. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/ journal/120-1250/2444/ Hider, P., Lay-Yee, R., Crampton, P., & Davis, P. F. (2007). Comparison of services provided by urban commercial, community- governed and traditional primary care practices in New Zealand. Journal of Health Services Research and Policy, 12(4), 215-222. Hill, S., Blakely, T., Kawachi, I., & Woodward, A. (2007). Mortality among lifelong nonsmokers exposed to secondhand smoke at home: Cohort data and sensitivity analyses. American Journal of Epidemiology, 165(5), 530-540. Howden-Chapman, P. L., Matheson, A., Crane, J., Viggers, H. E., Cunningham, M., Blakely, T. A., Cunningham, C., Woodward, A., Saville-Smith, K., O’Dea, D., Kennedy, M., Baker, M. G., Waipara, N., Chapman, R., & Davie, G. S. (2007). Effect of insulating existing houses on health inequality: Cluster randomised study in the community. BMJ, 334, 460. http://www. bmj.com/cgi/content/full/334/7591/460 Hudson, S., & Inkson, K. (2007). Overseas development workers: ‘Big Five’ personality scores. Journal of Pacific Rim Psychology, 1(1), 5-9. Hudson, S., Thomson, G., & Wilson, N. (2007). A pilot qualitative study of New Zealand policymakers knowledge of, and attitudes to, the tobacco industry. Australia and New Zealand Health Policy, 4(17). http://www.anzhealthpolicy.com/ content/pdf/1743-8462-4-17.pdf Irwin, C., Hunn, M., Purdie, G., & Hamilton, D. (2007). Delay in radiotherapy shortens survival in patients with high grade glioma. Journal of Neuro-Oncology, 85, 339-343. Jatrana, S., & Chan, A. (2007). Do socioeconomic effects on health diminish with age? A Singapore case study. Journal of Cross-Cultural Gerontology, 22, 287-301. Keall, M., Newstead, S., & Jones, W. (2007). Projecting effects of improvements in passive safety of the New Zealand light vehicle fleet. Traffic Injury Prevention, 8, 275-280.

Division of HEALTH SCIENCES 159 Leisnham, P. T., Slaney, D. P., Lester, P. J., Weinstein, P., & Heath, A. C. G. (2007). Mosquito density, macroinvertebrate diversity, and water chemistry in water-filled containers: Relationships to land use. New Zealand Journal of Zoology, 34, 203-218. McSweeny, K., Colman, A., Fancourt, N., Parnell, M., Stantiall, S., Rice, G., Baker, M. G., & Wilson, N. (2007). Was rurality protective in the 1918 influenza pandemic in New Zealand? The New Zealand Medical Journal, 120(1256). http://www. nzma.org.nz/journal/120-1256/2579/ Mhurchu, C. N., Blakely, T., Wall, J., Rodgers, A., Jiang, Y., & Wilton, J. (2007). Strategies to promote healthier food purchases: A pilot supermarket intervention study. Public Health Nutrition, 10(6), 608-615. Moradi, P., Thornton, J., Edwards, R., Harrison, R. A., Washington, S. J., & Kelly, S. P. (2007). Teenagers’ perceptions of blindness related to smoking: A novel message to a vulnerable group. British Journal of Ophthalmology, 91, 605-607. Novak, B., Bullen, C., Howden-Chapman, P., & Thornley, S. (2007). Blue-collar workplaces: A setting for reducing heart health inequalities in New Zealand? The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/ journal/120-1261/2704/ Pearce, J., Barnett, R., Collings, S., & Jones, I. (2007). Did geographical inequalities in suicide among men aged 15-44 in New Zealand increase during the period 1980-2001? Australian and New Zealand Journal of Psychiatry, 41, 359-365. Pearce, J., Blakely, T., Witten, K., & Bartie, P. (2007). Neighborhood deprivation and access to fast-food retailing. A national study. American Journal of Preventive Medicine, 32(5), 375-382. Pearce, J., Witten, K., Hiscock, R., & Blakely, T. A. (2007). Are socially disadvantaged neighbourhoods deprived of health- related community resources? International Journal of Epidemiology, 36, 348-355. Perera, R., Dowell, T., Crampton, P., & Kearns, R. (2007). Panning for gold: An evidence-based tool for assessment of performance indicators in primary health care. Health Policy, 80, 314-327. Roberts, M. G., Baker, M., Jennings, L. C., Sertsou, G., & Wilson, N. (2007). A model for the spread and control of pandemic influenza in an isolated geographical region. Journal of the Royal Society Interface, 4, 325-330. Robson, B. H., Purdie, G. L., Cram, F., & Simmonds, S. (2007). Age standardisation: An indigenous standard? Emerging Themes in Epidemiology, 4. http://www.ete-online.com/content/4/1/3 Sheuya, S., Howden-Chapman, P., & Patel, S. (2007). The design of housing and shelter programs: The social and environmental determinants of inequalities. Journal of Urban Health, 84(Suppl. 1), i98-i108. Signal, L. N., Martin, J., Reid, P., Carroll, C., Howden-Chapman, P. L., Keefe-Ormsby, V., Richards, R., Robson, B., & Wall, T. (2007). Tackling health inequalities: Moving theory to action. International Journal for Equity in Health, 6. http://www. equityhealthj.com/content/6/1/12 Snell, A. E., Graves, S., Kane, R., Ward, V., Slaney, D., Mercer, A., Hearnden, M., & Weinstein, P. (2007). Pilot testing a genus wide PCR-based system for arbovirus detection in mosquitoes in New Zealand. The Weta, 33, 6-13. Thomson, G., Wilson, N., & Howden-Chapman, P. (2007). The use and misuse of health research by parliamentary politicians during the development of a national smokefree law. Australia and New Zealand Health Policy, 4(24). http://www. anzhealthpolicy.com/content/4/1/24 Thornton, J., Edwards, R., Harrison, R. A., Elton, P., Astbury, N., & Kelly, S. P. (2007). ‘Smoke gets in your eyes’: A research- informed professional education and advocacy programme. Journal of Public Health, 29(2), 142-146. Thornton, J., Kelly, S. P., Harrison, R. A., & Edwards, R. (2007). Cigarette smoking and thyroid eye disease: A systematic review. Eye, 21, 1135-1145. Tobias, M., Cheung, J., Carter, K., Anderson, C., & Feigin, V. L. (2007). Stroke surveillance: Population-based estimates and projections for New Zealand. Australian and New Zealand Journal of Public Health, 31(6), 520-525. Wilson, N., Edwards, R., Maher, A., Nathe, J., & Jalali, R. (2007). National smokefree law in New Zealand improves air quality inside bars, pubs and restaurants. BMC Public Health, 7(85). Wilson, N., Maher, A., Thomson, G., & Keall, M. (2007). Smooth handling: The lack of safety-related consumer information in car advertisements. Injury Prevention, 13, 304-306. Wilson, N., Sertsou, G., Edwards, R., Thomson, G. W., Grigg, M., & Li, J. (2007). A new national smokefree law increased calls to a national quitline. BMC Public Health, 7(75). http://www.biomedcentral.com/1471-2458/7/75

Journal – Research Other Baker, M. G., & Forsyth, A. M. (2007). The new International Health Regulations: A revolutionary change in global health security. The New Zealand Medical Journal, 120(1267). http://www.nzma.org.nz/journal/120-1267/2872/ Baker, M., Keall, M., Au, E. L., & Howden-Chapman, P. (2007). Home is where the heart is - most of the time [Letter]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2769 Garrett, S., Dowell, T., Bos, V., Collings, S., McBain, L., & McKinlay, E. (2007). The challenge of improving access to mental health services within a primary care setting. New Zealand Family Physician, 34(1), 25-29. Wilson, N., Peace, J., Thomson, G., & Edwards, R. (2007). The prevalence of misleading tobacco descriptors in the New Zealand tobacco market [Letter]. The New Zealand Medical Journal, 120(1252). http://www.nzma.org.nz/ journal/120-1252/2497/ Wilson, N., & Thomson, G. (2007). Increase in violent deaths of Iraqi journalists since the 2003 invasion [Letter to the editor]. Medicine, Conflict and Survival, 23(2), 145-146. Wilson, N., & Thomson, G. (2007). Talking health, doing harm: New Zealand Government investment in industries that kill [Letter]. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2452/

160 RESEARCH REPORT 2007/2008 Wilson, N., Thomson, G., & Edwards, R. (2007). Lessons from Hong Kong and other countries for outdoor smokefree areas in New Zealand. The New Zealand Medical Journal, 120(1257). http://www.nzma.org.nz/journal/120-1257/2624 Wilson, N., Thomson, G. W., & Jenkin, G. (2007). More evidence for action on New Zealand’s obesogenic school environment and food pricing. The New Zealand Medical Journal, 120(1248). http://www.nzma.org.nz/journal/120-1248/2397/ Wilson, N., Watts, C., Mansoor, O., Jenkin, G., & Baker, M. G. (2007). Cheaper than chicken: Protein foods ranked by supermarket prices [Letter]. The New Zealand Medical Journal, 120(1259). http://www.nzma.org.nz/ journal/120-1259/2665/

Journal – Professional & Other Non-Research Articles Baker, M., Wilson, N., & Edwards, R. (2007). Campylobacter infection and chicken: An update on New Zealand’s largest ‘common source outbreak’ [Letter]. The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/ journal/120-1261/2717/ Edwards, R., & Wilson, N. (2007). Lessons for the criminal justice process from evidence-based medical practice? [Letter]. New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2480/ Edwards, R., Wilson, N., & Mansoor, O. (2007). Taxes for health: The argument is more about health than economics [Letter]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2790/ Hales, S., & Howden-Chapman, P. (2007). Effects of air pollution on health: Quantifying the effect alone is not enough to change policy and improve health. British Medical Journal, 335, 314-315. Small, K., & Signal, L. (2007). The price of healthy eating: Further research urgently needed [Letter]. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2481/ Thomson, G. W., & Wilson, N. (2007). Persisting loopholes in New Zealand’s smokefree law on tobacco marketing [Letter]. The New Zealand Medical Journal, 120(1256). http://www.nzma.org.nz/journal/120-1256/2597/ Wilson, N., Borland, R., Edwards, R., Allen, M., & Tukuitonga, C. (2007). Tobacco-free countries: Could Pacific Island countries lead the way? [Letter]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/ journal/120-1266/2845/ Wilson, N., & Gombojav, T. (2007). Mongolia: Proportion of tobacco tax for health [News analysis]. Tobacco Control, 16, 294-295. Wilson, N., & Melhuish, M. (2007). Addressing the threat of climate change: Is New Zealand lagging behind? [Letter]. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2479/

Commissioned Report for External Body Dowell, T., Garrett, S., Collings, S., McBain, L., McKinlay, E., & Stanley, J. (2007). Primary mental health initiatives evaluation: Interim report. Commissioned by Ministry of Health. Wellington, New Zealand: Department of Primary Health Care & General Practice, University of Otago, 242p. http://www.wnmeds.ac.nz/academic/gp/mentalhealth/ indexoctoberinterimreport.html.

Working Paper; Discussion Paper; Technical Report Peace, J., Wilson, N., Thomson, G. W., & Edwards, R. (2007). Colouring of cigarette packs in New Zealand, does it mislead consumers? Wellington, New Zealand: Department of Public Health, University of Otago.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF RADIATION THERAPY

Journal – Research Article Herst, P. M., & Berridge, M. V. (2007). Cell surface oxygen consumption: A major contributor to cellular oxygen consumption in glycolytic cancer cell lines. Biochimica et Biophysica Acta, 1767, 170-177. Herst, P. M., Petersen, T. R., Jerram, P., Baty, J., & Berridge, M. V. (2007). The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Biochemical Pharmacology, 74(11), 1587-1595.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF SURGERY AND ANAESTHESIA

Journal – Research Article Birchall, W., Bedggood, A., & Wells, A. P. (2007). Do scleral flap dimensions influence reliability of intraocular pressure control in experimental trabeculectomy? Eye, 21, 402-407. Delahunt B, Bethwaite PB, McCredie MRE, Nacey JN. (2007). The evolution of Collagen expression in sarcomatoid renal cell carcinoma. Human pathology 38 1372-1377. Delahunt B, Bethwaite PB, Nacey JN. (2007). Outcome prediction for renal cell carcinoma: evaluation of prognostic factors for tumours divided according to histologic subtype. Pathology 39 (5) 459-465.

Division of HEALTH SCIENCES 161 Lamb DS, Slaney D, Smart R, Nacey JN, Russell G, Scott B, Johnson CA, Adams JD, Moran S, Delahunt B. Prostate Cancer: the new evidence base for diagnosis and treatment. Pathology 39 (6) 1-8 (2007). Lever, N., Newall, E., & Larsen, P. D. (2007). Differences in the characteristics of induced and spontaneous episodes of ventricular fibrillation. Europace, 9, 1054-1058. Newall, E., Lever, N., Prasad, S., Hornabrook, C., & Larsen, P. D. (2007). Psychological implications of ICD implantation in a New Zealand population. Eurospace, 9, 20-24. Parnell, M. M., & Larsen, P. D. (2007). Poor quality teaching in lay person CPR courses. Resuscitation, 73, 271-278. Reeves, G., Wallis, R., Crowston, J. G., Small, K., & Wells, A. P. (2007). The effect of ICG on mitomycin C cytotoxicity in human tenon fibroblasts. Journal of Glaucoma, 16(5), 479-482. Sehat, K., Devane, P., & Horne, G. (2007). Fixed-bearing or mobile-bearing total knee arthroplasty? A review of the recent literature. Current Opinion in Orthopaedics, 18(1), 66-70. Thurston, A. J. (2007). Paré and prosthetics: The early history of artificial limbs. ANZ Journal of Surgery, 77, 1114-1119. Tzeng, Y. C., Larsen, P. D., & Galletly, D. C. (2007). Effects of hypercapnia and hypoxemia on respiratory sinus arrhythmia in conscious humans during spontaneous respiration. American Journal of Physiology – Heart and Circulatory Physiology, 292, H2397-H2407. Tzeng, Y. C., Larsen, P. D., & Galletly, D. C. (2007). Mechanism of cardioventilatory coupling: Insights from cardiac pacing, vagotomy, and sinoaortic denervation in the anesthetized rat. American Journal of Physiology – Heart and Circulatory Physiology, 292, H1967-H1977. Wells, A. P., James, K., Birchall, W., & Wong, T. (2007). Information loss in 2 bleb grading systems. Journal of Glaucoma, 16(2), 246-250.

Journal – Professional & Other Non-Research Articles Thurston, A. J. (2007). The Cowlishaw Symposium: A perspective. ANZ Journal of Surgery, 77, 1034-1035.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEAN’S DEPARTMENT

Journal – Research Article Epton, M. J., Town, G. I., Ingham, T., Wickens, K. L., Fishwick, D., Crane, J., the New Zealand Asthma and Allergy Birth Cohort Study Group, including Duignan, M., Fitzharris, P., Kelly, R., Lampshire, P., Leadbitter, P., Nicholson, A., Pattemore, P. K., Siebers, R. W., Silvers, K. M., & Withell, K. A. (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7(26), 26. http://www.biomedcentral.com/1471-2458/7/26

Journal – Professional & Other Non-Research Articles Cunningham, E. H., Cameron, V. A., Evans, J., Irvine, V., Pitama, S., & Robertson, P. (2007). The development of guidelines for handling samples and specimens collected for research involving Mäori [Letter]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2785/

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF ANAESTHESIA

Chapter in Book – Research Shipton, E. A. (2007). Multimodal analgesia in postoperative pain. In R. F. Schmidt & W. D. Willis (Eds.), Encyclopedia of pain (pp. 1197-1198). Berlin, Germany: Springer-Verlag. Shipton, E. A. (2007). Postoperative pain, epidural infusions. In R. F. Schmidt & W. D. Willis (Eds.), Encyclopedia of pain (pp. 1882-1884). Berlin, Germany: Springer-Verlag. Shipton, E. A. (2007). Postoperative pain, intrathecal drug administration. In R. F. Schmidt & W. D. Willis (Eds.), Encyclopedia of pain (pp. 1891-1893). Berlin, Germany: Springer-Verlag. Shipton, E. A. (2007). Postoperative pain, persistant acute pain. In R. F. Schmidt & W. D. Willis (Eds.), Encyclopedia of pain (pp. 1923-1925). Berlin, Germany: Springer-Verlag.

Journal – Research Article Crawford, C., Ryan, K., & Shipton, E. A. (2007). Exploring general practitioner identification and managment of psychosocial Yellow Flags in acute low back pain. The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/ journal/120-1254/2536/ Evans, S., Keenan, T. R., & Shipton, E. A. (2007). Psychosocial adjustment and physical health of children living with maternal chronic pain. Journal of Paediatrics and Child Health, 43, 262-270. Smith, S., Shipton, E. A., & Wells, J. E. (2007). In-hospital cardiac arrest: Different wards show different survival patterns. Anaesthesia and Intensive Care, 35(4), 522-528.

162 RESEARCH REPORT 2007/2008 Journal – Research Other Frohlich, E., & Shipton, E. A. (2007). Can the development of pain management units be justified in an emerging democracy? South African Medical Journal, 97(9), 826-828. Shipton, E. (2007). [Review of the book The worst of evils: The fight against pain]. Anaesthesia and Intensive Care, 35(3), 457-458. Shipton, E. A. (2007). [Review of the book Pain medicine: The requisities in anesthesiology]. Anaesthesia and Intensive Care, 35(5), 814-815.

Edited Journal Davis, F. M. (Ed.). (2007, March). Diving and Hyperbaric Medicine, 37(1). Davis, F. M. (Ed.). (2007, June). Diving and Hyperbaric Medicine, 37(2). Davis, F. M. (Ed.). (2007, September). Diving and Hyperbaric Medicine, 37(3). Davis, F. M. (Ed.). (2007, December). Diving and Hyperbaric Medicine, 37(4).

UNIVERSITY OF OTAGO, CHRISTCHUCRH DEPARTMENT OF MEDICINE

Authored Book – Textbook & Other Gane, E., Stedman, C., Kyle, C., & Whittaker, N. (2007). Liver function testing in primary care. Dunedin, New Zealand: bpac, 31p.

Chapter in Book – Research Endre, Z. H. (2007). Hyponatraemia. In D. C. Harris, and Colleagues (Eds.), Clinical cases in kidney disease (pp. 3-24). Sydney, Australia: McGraw-Hill.

Chapter in Book – Textbook & Other Gardiner, S. J., & Woods, D. J. (2007). Drugs in pregnancy and lactation. In R. Walker & C. Whittlesea (Eds.), Clinical pharmacy and therapeutics (4th ed.). (pp. 681-690). Edinburgh, Scotland: Churchill Livingstone. Liddle, C., & Stedman, C. A. M. (2007). Hepatic metabolism of drugs. In J. Rodes, J-P. Benhamou, A. Blei, J. Reichen, & M. Rizzetto (Eds.), Textbook of hepatology: From basic science to clinical practice (3rd ed.). (pp. 241-249). Malden, MA: Blackwell. Nicholls, M. G., & Richards, A. M. (2007). Endocrine causes of hypertension. In J. Feehally, J. Floege, & R. J. Johnson (Eds.), Comprehensive clinical nephrology (pp. 443-454). Philadelphia: Mosby.

Journal – Research Article Abdulle, A. M., Nagelkerke, N. J. D., Adem, A., Abouchacra, S., Pathan, J. Y., Al-Rukhaimi, M., Suleiman, M. N., Mathew, M. C., Nicholls, M. G., & Obineche, E. N. (2007). Plasma N terminal pro-brain natriuretic peptide levels and its determinants in a multi-ethnic population. Journal of Human Hypertension, 21(8), 647-653. Baggish, A. L., van Kimmenade, R. R., Bayes-Genis, A., Davis, M., Lainchbury, J. G., Frampton, C., Pinto, Y., Richards, M. A., & Januzzi, J. L. (2007). Hemoglobin and N-Terminal pro-brain natriuretic peptide: Independent and synergistic predictors of mortality in patients with acute heart failure: Results from the International Collaborative of NT-proBNP (ICON) Study. Clinica Chimica Acta, 381, 145-150. Baird, T. E., Palmer, B. R., Frampton, C. M., Yandle, T. G., Skelton, L., Richards, A. M., & Cameron, V. A. (2007). Association of the aldosterone synthase gene C-344T polymorphism with risk factors and survival in a post-myocardial infarction cohort. Journal of Human Hypertension, 21, 256-258. Bang, A. S., Soule, S. G., Yandle, T. G., Richards, A. M., & Pemberton, C. J. (2007). Characterisation of proghrelin peptides in mammalian tissue and plasma. Journal of Endocrinology, 192, 313-323. Bayes-Genis, A., Lloyd-Jones, D. M., van Kimmenade, R. R. J., Lainchbury, J. G., Richards, A. M., Ordonez-Llanos, J., Santalo, M., Pinto, Y. M., & Januzzi, Jr, J. L. (2007). Effect of body mass index on diagnostic and prognostic usefulness of amino- terminal pro-brain natriuretic peptide in patients with acute dyspnea. Archives of Internal Medicine, 167(4), 400-407. Bird, P. A., Begg, E. J., Zhang, M., Keast, A. T., Murray, D. P., & Balkany, T. J. (2007). Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otology & Neurotology, 28, 1124-1130. Borrie, S., McAuliffe, M., Tillard, G., Ormond, T., Anderson, T. J., & Hornibrook, J. (2007). Effect of the Lee Silverman Voice Treatment (LSVT) on articulation in speakers with Parkinson’s Disease. New Zealand Journal of Speech-Language Therapy, 62, 29-36. Brooks, A., Begg, E. J., Zhang, M., Frampton, C. M., & Barclay, M. L. (2007). Red blood cell methotrexate polyglutamate concentrations in inflammatory bowel disease. Therapeutic Drug Monitoring, 29(5), 619-625. Browning, B. L., Huebner, C., Petermann, I., Demmers, P., McCulloch, A., Gearry, R. B., Barclay, M. L., Shelling, A. N., & Ferguson, L. R. (2007). Association of DLG5 variants with inflammatory bowel disease in the New Zealand caucasian population and meta-analysis of the DLG5 R30Q variant. Inflammatory Bowel Diseases, 13(9), 1069-1076.

Division of HEALTH SCIENCES 163 Browning, B. L., Huebner, C., Petermann, I., Gearry, R. B., Barclay, M. L., Shelling, A. N., & Ferguson, L. R. (2007). Has toll-like receptor 4 been prematurely dismissed as an inflammatory bowel disease gene? Association study combined with meta- analysis shows strong evidence for association. American Journal of Gastroenterology, 102, 2504-2512. Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Darlow, B. A. (2007). Infants admitted to a neonatal intensive care unit: Parental psychological status at 9 months. Acta Paediatrica, 96, 1286-1289. Cavanagh, J-E., Brown, L., Trought, K., Kingham, S., & Epton, M. J. (2007). Elevated concentrations of 1-hydroxypyrene in schoolchildren during winter in Christchurch, New Zealand. Science of the Total Environment, 374, 51-59. Chambers, S. T., Pithie, A., Gallagher, K., Liu, T., Charles, C. J., & Seaward, L. M. (2007). Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: Efficacy in a sheep model. Journal of Antimicrobial Chemotherapy, 59, 779-782. Charles, C. J. (2007). Putative role for apelin in pressure/volume homeostasis and cardiovascular disease. Cardiovascular and Hematological Agents in Medicinal Chemistry, 5, 1-10. Charles, C. J., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 1 modulates the neurohumoral response to acute nitroprusside-induced hypotension in sheep. Clinical Science, 112, 485-491. Chase, J. G., Shaw, G. M., Lotz, T., LeCompte, A., Wong, J., Lin, J., Lonergan, T., Willacy, M., & Hann, C. E. (2007). Model- based insulin and nutrition administration for tight glycaemic control in critical care. Current Drug Delivery, 4, 283-296. Davidson, P. R., Jones, R. D., & Peiris, M. T. R. (2007). EEG-based lapse detection with high temporal resolution. IEEE Transactions on Biomedical Engineering, 54(5), 832-839. Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in human heart failure. European Heart Journal, 28(21), 2589-2597. Davis, M. E., Pemberton, C. J., Yandle, T. G., Fisher, S. F., Lainchbury, J. G., Frampton, C. M., Rademaker, M. T., & Richards, A. M. (2007). Urocortin 2 infusion in healthy humans: Hemodynamic, neurohormonal, and renal responses. Journal of the American College of Cardiology, 49(4), 461-471. Denic, S., Frampton, C. M., Nagelkerke, N., & Nicholls, M. G. (2007). Consanguinity affects selection of alpha-thalassemia genotypes and the size of populations under selection pressure from malaria. Annals of Human Biology, 34(6), 620-631. Denic, S., Frampton, C. M., & Nicholls, M. G. (2007). Risk of cancer in an inbred population. Cancer Detection and Prevention, 31(4), 263-269. Denic, S., & Nicholls, M. G. (2007). Genetic benefits of consanguinity throught selection of genotypes protective against malaria. Human Biology, 79(2), 145-158. Doeltgen, S. H., Hofmayer, A., Gumbley, F., Witte, U., Moran, C., Carroll, G. J., & Huckabee, M-L. (2007). Clinical measurement of pharyngeal surface electromyography: Exploratory research. Neurorehabilitation and Neural Repair, 21, 250-262. Ellmers, L. J., Scott, N. J. A., Piuhola, J., Maeda, N., Smithies, O., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of Molecular Endocrinology, 38, 245-257. Epton, M. J., Town, G. I., Ingham, T., Wickens, K. L., Fishwick, D., Crane, J., the New Zealand Asthma and Allergy Birth Cohort Study Group, including Duignan, M., Fitzharris, P., Kelly, R., Lampshire, P., Leadbitter, P., Nicholson, A., Pattemore, P. K., Siebers, R. W., Silvers, K. M., & Withell, K. A. (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7(26), 26. http://www.biomedcentral.com/1471- 2458/7/26 Forrest, R. H., Hickford, J. G. H., & Frampton, C. M. (2007). Polymorphism at the ovine beta 3-adrenergic receptor locus (ADRB3) and its association with lamb mortality. Journal of Animal Science, 85, 2801-2806. Gearry, R. B., Ajlouni, Y., Nandurkar, S., Iser, J. H., & Gibson, P. R. (2007). 5-Aminosalicylic acid (Mesalazine) use in Crohn’s disease: A survey of the opinions and practice of Australian gastroenterologists. Inflammatory Bowel Diseases, 13(8), 1009-1015. Gearry, R. B., Roberts, R. L., Burt, M. J., Frampton, C. M., Chapman, B. A., Collett, J., Shirley, P., Allington, M. D. E., Kennedy, M. A., & Barclay, M. L. (2007). Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort. Inflammatory Bowel Diseases, 13(10), 1220-1227. Gilchrist, N. L., Frampton, C. M., Acland, R. H., Nicholls, M. G., March, R. L., Maguire, P., Heard, A., Reilly, P., & Marshall, K. (2007). Alendronate prevents bone loss in patients with acute spinal cord injury: A randomized, double-blind, placebo- controlled study. Journal of Clinical Endocrinology & Metabolism, 92(4), 1385-1390. Gobe, G. C., Endre, Z. H., & Johnson, D. W. (2007). Administration of erythropoietin and its derivatives in renal disease: Advantages, mechanisms and concerns. Drug Discovery Today: Therapeutic Strategies, 4(1), 79-84. Gunningham, S. P., Currie, M. J., Morrin, H. R., Tan, E. J., Turley, H., Dachs, G. U., Watson, A. I., Frampton, C., Robinson, B. A., & Fox, S. B. (2007). The angiogenic factor thymidine phosphorylase up-regulates the cell adhension molecule P-selectin in human vascular endothelial cells and is associated with P-selectin expression in breast cancers. Journal of Pathology, 212, 335-344. Hanger, C., Fletcher, V., Fink, J., Sidwell, A. I., & Roche, A. (2007). Improving care to stroke patients: Adding an acute stroke unit helps. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2450/ Hanger, H. C., Wilkinson, T. J., Fayez-Iskander, N., & Sainsbury, R. (2007). The risk of recurrent stroke after intracerebral haemorrhage. Journal of Neurology, Neurosurgery and Psychiatry, 78, 836-840.

164 RESEARCH REPORT 2007/2008 Harvey, M. A., Sellman, J. D., Porter, R. J., & Frampton, C. M. (2007). The relationship between non-acute adolescent cannabis use and cognition. Drug and Alcohol Review, 26, 309-319. Heitger, M. H., Jones, R. D., Dalrymple-Alford, J. C., Frampton, C. M., Ardagh, M. W., & Anderson, T. J. (2007). Mild head injury: A close relationship between motor function at 1 week post-injury and overall recovery at 3 and 6 months. Journal of the Neurological Sciences, 253, 34-47. Heitger, M. H., Jones, R. D., Frampton, C. M., Ardagh, M. W., & Anderson, T. J. (2007). Recovery in the first year after mild head injury: Divergence of symptom status and self-perceived quality of life. Journal of Rehabilitation Medicine, 39(8), 612-621. Innes, C. R. H., Jones, R. D., Dalrymple-Alford, J. C., Hayes, S., Hollobon, S., Severinsen, J., Smith, G., Nicholls, A., & Anderson, T. J. (2007). Sensory-motor and cognitive tests predict driving ability of persons with brain disorders. Journal of the Neurological Sciences, 260, 188-198. Jacometti, M. A., Frampton, C. M., & Hickling, G. J. (2007). Factors influencing brushtail possum (Trichosurus vulpecula) damage in a Pinus radiata plantation on the Coromandel Peninsula, New Zealand. New Zealand Journal of Ecology, 31(2), 202-207. Jardine, D. L., Charles, C. J., Frampton, C. M., & Richards, A. M. (2007). Cardiac sympathetic nerve activity and ventricular fibrillation during acute myocardial infarction in a conscious sheep model. American Journal of Physiology: Heart and Circulatory Physiology, 293, H433-H439. Jenks, K. A., Stamp, L. K., O’Donnell, J. L., Savage, R. L., & Chapman, P. T. (2007). Leflunomide-associated infections in rheumatoid arthritis. Journal of Rheumatology, 34, 2201-2203. Jogia, P. M., Kalkoff, M., Sleigh, J. W., Bertinelli, A., La Pine, M., Richards, A. M., & Devlin, G. (2007). NT-pro BNP secretion and clinical endpoints in cardiac surgery intensive care patients. Anaesthesia and Intensive Care, 35(3), 363-369. Joyce, P. R., McKenzie, J. M., Carter, J. D., Rae, A. M., Luty, S. E., Frampton, C. M. A., & Mulder, R. T. (2007). Temperament, character and personality disorders as predictors of response to interpersonal psychotherapy and cognitive-behavioural therapy for depression. British Journal of Psychiatry, 190, 503-508. Joyce, P. R., Williamson, S. A. H., McKenzie, J. M., Frampton, C. M. A., Luty, S. E., Porter, R. J., & Mulder, R. T. (2007). Effects of childhood experiences on cortisol levels in depressed adults. Australian and New Zealand Journal of Psychiatry, 41, 62-65. Kelly, B. N., Huckabee, M-L., Jones, R. D., & Frampton, C. M. A. (2007). Integrating swallowing and respiration: Preliminary results of the effect of body position. Journal of Medical Speech-Language Pathology, 15(4), 347-355. Kelly, B. N., Huckabee, M-L., Jones, R. D., & Frampton, C. M. A. (2007). The early impact of feeding on infant breathing- swallowing coordination. Respiratory Physiology & Neurobiology, 156, 147-153. Kelly, B. N., Huckabee, M-L., Jones, R. D., & Frampton, C. M. A. (2007). The first year of human life: Coordinating respiration and nutritive swallowing. Dysphagia, 22, 37-43. Kelly, P. T., Hlavac, M., & Beckert, L. E. (2007). Episodic hypoxemia in an airline passenger with chronic respiratory failure on supplemental oxygen. Aviation, Space, and Environmental Medicine, 78(7), 712-715. Kemp, W., Krum, H., Colman, J., Bailey, M., Yandle, T. G., Richards, M. M., & Roberts, S. (2007). Urotensin II: A novel vasoactive mediator linked to chronic liver disease and portal hypertension. Liver International, 27(9), 1232-1239. Leef, M. J., Hill, J. V., Harris, J. O., & Powell, M. D. (2007). Increased systemic vascular resistance in Atlantic salmon, Salmo salar L., affected with amoebic gill disease. Journal of Fish Diseases, 30, 601-613. Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29. Lucas, R. M., Ponsonby, A-L., McMichael, A. J., van der Mei, I., Chapman, C., Coulthard, A., Dear, K., Dwyer, T., Kilpatrick, T. J., Pender, M. P., Taylor, B. V., Valery, P., & Williams, D. (2007). Observational analytic studies in multiple sclerosis: Controlling bias through study design and conduct: The Australian Multicentre Study of Environment and Immune Function. Multiple Sclerosis, 13, 827-839. Luty, S. E., Carter, J. D., McKenzie, J. M., Rae, A. M., Frampton, C. M. A., Mulder, R. T., & Joyce, P. R. (2007). Randomised controlled trial of interpersonal psychotherapy and cognitive-behavioural therapy for depression. British Journal of Psychiatry, 190, 496-502. McAuley, K. A., Mann, J. I., Chase, J. G., Lotz, T. F., & Shaw, G. M. (2007). HOMA: The best bet for the simple determination of insulin sensitivity, until something better comes along. Diabetes Care, 30(9), 2411-2413. McKechnie, R., MacLeod, R., & Keeling, S. (2007). Facing uncertainty: The lived experience of palliative care. Palliative and Supportive Care, 5, 255-264. Menzies, J., Magee, L. A., MacNab, Y. C., Ansermino, J. M., Li, J., Douglas, M. J., Gruslin, A., Kyle, P., Lee, S. K., Moore, M. P., et al. (2007). Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertension in Pregnancy, 26(4), 447-462. Meuli, K., Chapman, P. T., O’Donnell, J., Frampton, C. M., & Stamp, L. (2007). Audit of pneumocystis pneumonia in patients seen by the Christchurch Hospital rheumatology service over a 5-year period. Internal Medicine Journal, 37, 687-692. Mocatta, T. J., Pilbrow, A. P., Cameron, A. V., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. Journal of the American College of Cardiology, 49(20), 1993-2000. Muthu, C., Chu, J. J., Le Heron, C., Roake, J. A., & Lewis, D. R. (2007). Patient awareness of risk factors for perpheral vascular disease. Annals of Vascular Surgery, 21(4), 433-437.

Division of HEALTH SCIENCES 165 Newnham, E., Hawkes, E., Surender, A., James, S. L., Gearry, R., & Gibson, P. R. (2007). Quantifying exposure to diagnostic medical radiation in patients with inflammatory bowel disease: Are we contributing to malignancy? Alimentary Pharmacology & Therapeutics, 26, 1019-1024. O’Donnell, J. L., Hayman, M. W., Spellerberg, M. B., McLellan, A. D., Brooksbank, K., Chapman, P. T., & Stamp, L. K. (2007). Antineutrophil cytoplasmic antibody measurement: Advantages and disadvantages of a capture PR3 ELISA and a direct PR3 ELISA. Pathology, 39(2), 258-263. O’Donnell, J. L., Stevanovic, V. R., Frampton, C. M., Stamp, L. K., & Chapman, P. T. (2007). Wegener’s granulomatosis in New Zealand: Evidence for a latitude-dependent incidence gradient. Internal Medicine Journal, 37, 242-246. Olney, R. C., Prickett, T. C. R., Yandle, T. G., Espiner, E. A., Han, J. C., & Mauras, N. (2007). Amino-terminal propeptide of C-type natriuretic peptide and linear growth in children: Effects of puberty, testosterone, and growth hormone. Journal of Clinical Endocrinology and Metabolism, 92(11), 4294-4298. Palmer, S. C., McGregor, D. O., Macaskill, P., Craig, J. C., Elder, G. J., & Strippoli, G. F. M. (2007). Meta-analysis: Vitamin D compounds in chronic kidney disease. Annals of Internal Medicine, 147(12), 840-853. Palmer, S. C., McGregor, D. O., & Strippoli, G. F. (2007). Interventions for preventing bone disease in kidney transplant recipients (Review). Cochrane Database of Systematic Reviews, (3), CD005015. http://mrw.interscience.wiley.com/ cochrane/clsysrev/articles/CD005015/frame.html Pescovitz, D. M., Jain, A., Robson, R., Mulgaonkar, S., Freeman, R., & Bouw, R. M. (2007). Establishing pharmacokinetic bioequivalence of valganciclovir oral solution versus the tablet formulation. Transplantation Proceedings, 39, 3111-3116. Pilbrow, A. P., Palmer, B. R., Frampton, C. M., Yandle, T. G., Troughton, R. W., Campbell, E., Skelton, L., Lainchbury, J. G., Richards, A. M., & Cameron, V. A. (2007). Angiotensinogen M235T and T17M gene polymorphisms in combination doubles the risk of mortality in heart failure. Hypertension, 49(2), 322-327. Prickett, T. C. R., Barrell, G. K., Wellby, M., Yandle, T. G., Richards, A. M., & Espiner, E. A. (2007). Response of plasma CNP forms to acute anabolic and catabolic interventions in growing lambs. American Journal of Physiology Endocrinology and Metabolism, 292, E1395-E1400. Prickett, T. C. R., Rumball, C. W. H., Buckley, A. J., Bloomfield, F. H., Yandle, T. G., Harding, J. E., & Espiner, E. A. (2007). C-type natriuretic peptide forms in the ovine fetal and maternal circulations: Evidence for independent regulation and reciprocal response to undernutrition. Endocinology, 148(8), 4015-4022. Proudman, S. M., Keen, H. I., Stamp, L. K., Lee, A. T. Y., Goldblatt, F., Ayres, O. C., Rischmueller, M., James, M. J., Hill, C. L., Caughey, G. E., & Cleland, L. G. (2007). Response-driven combination therapy with conventional disease-modifying antirheumatic drugs can achieve high response rates in early rheumatoid arthritis with minial glucocorticoid and nonsteroidal anti-inflammatory drug use. Seminars in Arthritis and Rheumatism, 37(2), 99-111. Rademaker, M. T., Charles, C. J., & Richards, A. M. (2007). Urocortin 1 administration from onset of rapid left ventricular pacing represses progression to overt heart failure. American Journal of Physiology: Heart and Circulatory Physiology, 293, 1536-1544. Rimmer, J., Peake, H. L., Santos, C. M. C., Lean, M., Bardin, P., Robson, R., Haumann, B., Loehrer, F., & Handel, M. L. (2007). Targeting adenosine receptors in the treatment of allergic rhinitis: A randomized, double-blind, placebo-controlled study. Clinical and Experimental Allergy, 37, 8-14. Ritzema, J., Melton, I. C., Richards, A. M., Crozier, I. G., Frampton, C., Doughty, R. N., Whiting, J., Kar, S., Eigler, N., Krum, H., Abraham, W. T., & Troughton, R. W. (2007). Direct left atrial pressure monitoring in ambulatory heart failure patients: Initial experience with a new permanent implantable device. Circulation, 116(25), 2952-2959. Roberts, R., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., Timms, K. M., Gutin, A., Lanchbury, J. S., Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn’s disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology, 102, 2754-2761. Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). IMPDH1 promoter mutations in a patient exhibiting azathioprine resistence. The Pharmacogenomics Journal, 7(5), 312-317. Rubio, J. P., Bahlo, M., Stankovich, J., Burfoot, R. K., Johnson, L., Huxtable, S., Butzkueven, H., Lin, L., Taylor, B. V., Speed, T. P., Kilpatrick, T. J., Foote, S. J., & Mignot, E. (2007). Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. Immunogenetics, 59, 177-186. Saadi, H., Carruthers, S. G., Nagelkerke, N., Al-Maskari, F., Afandi, B., Reed, R., Lukic, M., Nicholls, M. G., et al. (2007). Prevalence of diabetes mellitus and its complications in a population-based sample in Al Ain, United Arab Emirates. Diabetes Research and Clinical Practice, 78(3), 369-377. Sabel, C. E., Wilson, J. G., Kingham, S., Tisch, C., & Epton, M. (2007). Spatial implications of covariate adjustment on patterns of risk: Respiratory hospital admissions in Christchurch, New Zealand. Social Science and Medicine, 65, 43-59. Scott, R. S., Wu, M., Fernandez-Sanchez, M., & Stein, P. (2007). Efficacy and tolerability of teh dipeptidyl peptase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes. International Journal of Clinical Practice, 61(1), 171-180. Shand, B., Elder, P., Scott, R. S., Poa, N. R., & Frampton, C. M. (2007). Comparison of plasma adiponectin levels in New Zealand Mäori and Caucasian individuals. The New Zealand Medical Journal, 120(1257). http://www.nzma.org.nz/ journal/120-1257/2606/ Shand, B., Scott, R. S., Connolly, S., Clarke, R., Baker, J., Elder, P., Frampton, C. M., & Yeo, J. (2007). Comparative study on the efficacy of pioglitazone in Caucasian and Mäori-Polynesian patients with poorly controlled type 2 diabetes. Diabetes, Obesity and Metabolism, 9, 540-547.

166 RESEARCH REPORT 2007/2008 Shaw, G. M., Chase, J. G., Starfinger, C., Smith, B. W., Hann, C. E., Desaive, T., & Ghuysen, A. (2007). Modelling the cardiovascular system. Critical care and Resuscitation, 9(3), 264-269. Sheehan, D., Thwaites, J. H., & Byrnes, I. (2007). General practice rotations for post graduate year 1 and 2 house officers: How feasible? The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/journal/120-1264/2770/ Sheehan, D., & Wilkinson, T. J. (2007). Maximising the clinical learning of junior doctors: Applying educational theory to practice. Medical Teacher, 29, 827-829. Sigurdsson, G., Troughton, R. W., Xu, X-F., Salazar, H. P., Wazni, O. M., Grimm, R. A., White, R. D., Natale, A., & Klein, A. L. (2007). Detection of pulmonary vein stenosis by transesophageal echocardiography: Comparison with multidetector computed tomography. American Heart Journal, 153(5), 800-806. Silvers, K. M., Epton, M. J., & Frampton, C. M. (2007). Study was not designed to test the hypothesis [Letter]. British Medical Journal, 335, 899. Smith, J. D., Prideaux, D., Wolfe, C. L., Wilkinson, T. J., Gupta, T. S., DeWitt, D. E., Worley, P., Hays, R. B., & Cowie, M. (2007). Developing the accredited postgraduate assessment program for Fellowship of the Australian College of Rural and Remote Medicine. Rural and Remote Health, 7, 805. http://www.rrh.org.au/articles/subviewnew.asp?ArticleID=805 Stamp, L. K., O’Donnell, J. L., & Chapman, P. T. (2007). Emerging therapies in the long-term management of hyperuricaemia and gout. Internal Medicine Journal, 37, 258-266. Stewart, N., Taylor, B. V., Ponsonby, A-L., Pittas, F., van der Mei, I., Woods, G., & Walters, H. (2007). The effect of season on cytokine expression in multiple sclerosis and healthy subjects. Journal of Neuroimmunology, 188, 181-186. Stiven, P. N., Frampton, C. M., & Lewis, D. R. (2007). Use of autopsy in general surgery: A comparison of practice and opinion. ANZ Journal of Surgery, 77, 722-726. Tang, W. H. W., Tong, W., Troughton, R. W., Martin, M. G., Shrestha, K., Borowski, A., Jasper, S., Hazen, S. L., & Klein, A. L. (2007). Prognostic value and echocardiographic determinants of plasma myeloperoxidase levels in chronic heart failure. Journal of the American College of Cardiology, 49(24), 2364-2370. Taylor, B. V., Williamson, J., Jones, D., Coleman, D., Luck, J., & Alistair, M. (2007). Utility of serum Campylobacter specific antibodies in determining prior Campylobacter infection in neurological disease. Journal of Clinical Neuroscience, 14, 116-121. Thwaites, J. H., Mann, F., Gilchrist, N., McKie, J., & Sainsbury, R. (2007). Older patients with hip fractures: Evaluation of a long-term specialist orthopaedic medicine service in their outcomes. The New Zealand Medical Journal, 120(1254). http:// www.nzma.org.nz/journal/120-1254/2535/ Troughton, R. W., Richards, A. M., Yandle, T. G., Frampton, C. M., & Nicholls, M. G. (2007). The effects of medications on circulating levels of cardiac natriuretic peptides. Annals of Medicine, 39(4), 242-260. van der Mei, I. A., Ponsonby, A-L., Dwyer, T., Blizzard, L., Taylor, B. V., Kilpatrick, T., Butzkueven, H., & McMichael, A. J. (2007). Vitamin D levels in people with multiple sclerosis and community controls in Tasmania, Australia. Journal of Neurology, 254, 581-590. Vella-Brincat, J. W. A., Begg, E. J., Kirkpatrick, C., Zhang, M., Chambers, S. T., & Gallagher, K. (2007). Protein binding of cefazolin is saturable in vivo both between and within patients. British Journal of Clinical Pharmacology, 63(6), 753-757. Walter, M., Frampton, C. M., Boyd-Wilson, K. S. H., Harris-Virgin, P., & Waipara, N. W. (2007). Agrichemical impact on growth and survival of non-target apple phyllosphere microorganisms. Canadian Journal of Microbiology, 53(1), 45-55. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). Medical student characteristics associated with time in study: Is spending more time always a good thing? Medical Teacher, 29, 106-110. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). What is the educational impact of standards-based assessment in a medical degree? Medical Education, 41, 565-572. Wyber, R., & Egan, T. (2007). For better or worse: Role models for New Zealand house officers. The New Zealand Medical Journal, 120(1253). http://www.nzma.org.nz/journal/120-1253/2518/

Journal – Research Other Aronson, J. K., Cohen, A., Ritter, J. M., Begg, E. J., Lewis, L. D., & Schachter, M. (2007). Editors’ report for 2006. British Journal of Clinical Pharmacology, 64(3), 253-254. Beckert, L., & Edwards, A. (2007). Salamol: Was it worth it? The New Zealand Medical Journal, 120(1267). http://www.nzma. org.nz/journal/120-1267/2875/ Beckert, L., & Meyer, R. (2007). World No Tobacco Day (31 May 2007): Did anybody notice? The New Zealand Medical Journal, 120(1256). http://www.nzma.org.nz/journal/120-1256/2585/ Bridgman, P. G. (2007). “I’m glad I’m not young anymore” [General correspondence). Internal Medicine Journal, 37(6), 426. Bridgman, P. G., & Earwaker, P. L. (2007). The case for echocardiography in non-ST elevation myocardial infarction in New Zealand [Letter]. The New Zealand Medical Journal, 120(1265). http://www.nzma.org.nz/journal/120-1265/2813/ Brooks, A. J., Begg, E. J., Chapman, B. A., & Fitzharris, B. M. (2007). Two cases of severe liver injury possibly related to 5-fluorouracil and calcium folinate [Letter to the editor]. Internal Medicine Journal, 37(5), 344-345. Chase, J. G., & Shaw, G. M. (2007). Is there more to glycaemic control than meets the eye? Critical Care, 11(4). http://ccforum. com/content/pdf/cc6099.pdf Clare, G., & Troughton, R. W. (2007). Management of constrictive pericarditis in the 21st Century. Current Treatment Options in Cardiovascular Medicine, 9, 436-442.

Division of HEALTH SCIENCES 167 Dalbeth, N., & Stamp, L. (2007). Allopurinol dosing in renal impairment: Walking the tightrope between adequate urate lowering and adverse events. Seminars in Dialysis, 20(5), 391-395. Doogue, M., Soule, S., & Hunt, P. (2007). Another cause of ‘pseudophaeochromocytoma’: Quetiapine associated with a false positive normetanephrine result. Clinical Endocrinology, 67, 472-476. Endre, Z. H. (2007). Nephrogenic systemic fibrosis: Is any contrast safe in renal failure? [Editorial]. Internal Medicine Journal, 37, 429-431. Espiner, E. A., Prickett, T. C., Yandle, T. G., Barrell, G. K., Wellby, M., Sullivan, M. J., & Darlow, B. A. (2007). ABCs of natriuretic peptides: Growth. Hormone Research, 67(Suppl. 1), 81-90. Favaloro, E. J., Patterson, D., Denholm, A., Mead, S., Gilbert, A., Collins, A., Estell, J., George, P. M., & Smith, M. P. (2007). Differential identification of a rare form of platelet-type (pseudo-) von Willebrand disease (VWD) from Type 2B VWD using a simplified ristocetin-induced-platelet-agglutination mixing assay and confirmed by genetic analysis [Correspondence]. British Journal of Haematology, 139, 621-628. Gardiner, S. J., Begg, E. J., Sau, A., Marinaki, A., Gearry, R. B., & Barclay, M. L. (2007). Thiopurine treatment in inflammatory bowel disease [Letter to the editor]. Clinical Pharmacokinetics, 46(9), 803-804. Gardiner, S. J., Gearry, R. B., Roberts, R., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Comment: Breast-feeding during maternal use of azathioprine [Letter to the editor]. The Annals of Pharmacotherapy, 41(4), 719-720. Gearry, R. B., & Frizelle, F. A. (2007). Management of dysplasia in patients with ulcerative colitis by surgeons: Truth or speculation [Letter to the editor]. Gastrointestinal Endoscopy, 66(5), 1069-1070. Hanger, H. C. (2007). A stroke rehabilitation unit 6 years on [Letter]. The New Zealand Medical Journal, 120(1262). http:// www.nzma.org.nz/journal/120-1262/2739/ Highton, J., Hessian, P. A., & Stamp, L. K. (2007). The Rheumatoid nodule: Peripheral or central to rheumatoid arthritis? [Editorial]. Rheumatology, 46, 1385-1387. Isaacs, R. J., Frampton, C. M., & Kuper-Hommel, M. J. J. (2007). PHARMAC’s funding of 9 weeks Herceptin: Many assumptions in a high-risk decision. The New Zealand Medical Journal, 120(1259). http://www.nzma.org.nz/ journal/120-1259/2676/ Jardine, D. L., Hurrell, M. A., & Fink, J. (2007). Tilt-test diagnosis of hypotensive transcient ischaemic attacks [Communication]. Internal Medicine Journal, 37(7), 498-501. Nicholls, G. G., Richards, A. M., & on behalf of Christchurch Cardioendocrine Research Group (2007). Disease monitoring of patients with chronic heart failure. Heart, 93, 519-523. Palmer, B. R., Frampton, C. M., Richards, A. M., & Cameron, V. A. (2007). AMPD1 gene polymorphism and survival in patients with stable congestive heart failure [Letter to the editor]. American Heart Journal, 153, e13. Palmer, S. C., Craig, J. C., & Strippoli, G. F. M. (2007). Sevelamer: A promising but unproven drug. Nephrology Dialysis Transplantation, 22, 2742-2745. Pemberton, C. J. (2007). Hypertension, cardiotrophin-1 and gp130: Three points to heart failure? [Editorial comment]. Journal of Hypertension, 25(10), 2008-2010. Pemberton, C. J., & Richards, A. M. (2007). Biochemistry of ghrelin precursor peptides. Vitamins and Hormones, 77, 13-30. Richards, A. M. (2007). Does NT-proBNP testing reduce costs and improve accuracy in the diagnosis of heart failure? [Commentary]. Nature Clinical Practice Cardiovascular Medicine, 4(12), 652-653. Richards, A. M. (2007). Natriuretic peptides: Update on peptide release, bioactivity, and clinical use. Hypertension, 50(1), 25-30. Richards, A. M. (2007). Variability of NT-proBNP levels in heart failure: Implications for clinical application [Editorial]. Heart, 93, 899-900. Walker, H., Porter, R. J., Ritz, S., & Beckert, L. E. (2007). Late occurrence of clozapine-associated polyserositis [Letter to the editor]. International Journal of Neuropsychopharmacology, 10, 147-148. Wilkinson, T. (2007). Get the learning environment right and the facts will look after themselves [Editorial]. The New Zealand Medical Journal, 120(1253). http://www.nzma.org.nz/journal/120-1253/2511/ Wilkinson, T. J. (2007). Assessment of clinical performance: Gathering evidence. Internal Medicine Journal, 37, 631-636. Wilkinson, T. J., & Wade, W. B. (2007). Problems with using a supervisor’s report as a form of summative assessment. Postgraduate Medical Journal, 83, 504-506. Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., George, P. M., & Scott, R. S. (2007). Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia. The American Journal of Cardiology, 100, 1400-1403.

Journal – Professional & Other Non-Research Articles Beckert, L., & Ward, J. (2007). Professional development: Respiratory Researchers’ Short Course 2008. Thoracic Society News, 17(3), 47. Berkeley, J., Lunt, H., & Frampton, C. (2007). Efficacy of continuous subcutaneous insulin infusion (CSII) in patients with classical contraindications to its use [Letter: Original observations]. Diabetic Medicine, 24, 1496-1497. Cunningham, E. H., Cameron, V. A., Evans, J., Irvine, V., Pitama, S., & Robertson, P. (2007). The development of guidelines for handling samples and specimens collected for research involving Mäori [Letter]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2785/ Helm, J., & Beckert, L. (2007). [Review of the book There’s a lot of it about: Acute respiratory infections in primary care]. The New Zealand Medical Journal, 120(1255). http://www.nzma.org.nz/journal/120-1255/2573/

168 RESEARCH REPORT 2007/2008 Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). [Erratum to “An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency” [Biochimie 89 (2007) 21-29]]. Biochimie, 89, 1438. McAuley, K. A., Mann, J. I., Chase, J. G., Lotz, T. F., & Shaw, G. M. (2007). Point: HOMA: Satisfactory for the time being: HOMA: The best bet for the simple determination of insulin sensitivity, until something better comes along [Editorial]. Diabetes Care, 30(9), 2411-2413. Merriman, T., & Cameron, A. V. (2007). Risk-taking: Behind the warrior gene story. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2440/ Stamp, L. (2007). [Review of the book Joint and soft tissue injection (4th edition): Injecting with confidence]. The New Zealand Medical Journal, 120(1263). http://www.nzma.org.nz/journal/120-1263/2765/

Intellectual Property Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). Method of identifying individuals at risk of thiopurine drug resistance and intolerance. (60/935367).

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Journal – Research Article Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189. Evans, G. (2007). Review of molecular methods for medical microbiology testing. New Zealand Journal of Medical Laboratory Science, 61(3), 72-83. Jones, R. W., Coughlan, E. P., Reid, J. S., Sykes, P., Watson, P. D., & Cook, C. (2007). Human papilloma virus vaccines and their role in cancer prevention. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2829/ Menzies, J., Magee, L. A., MacNab, Y. C., Ansermino, J. M., Li, J., Douglas, M. J., Gruslin, A., Kyle, P., Lee, S. K., Moore, M. P., et al. (2007). Current CHS and NHBPEP criteria for severe preeclampsia do not uniformly predict adverse maternal or perinatal outcomes. Hypertension in Pregnancy, 26(4), 447-462. Savigny, P., Evans, J., & McGrath, K. M. (2007). Cell membrane structures during exocytosis. Endocrinology, 148(8), 3863-3874.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF ORTHOPAEDIC SURGERY AND MUSCULOSKELETAL MEDICINE

Chapter in Book Borowczyk J.M. 2007. Lumbar Transforaminal Injection of Steroids. In: Encyclopedia of Pain. Schmidt R.F. Willis W.D. Springer York, pp. 1081-1083. Borowczyk J.M. 2007. Visceral Pain and Nociception. In: Encyclopedia of Pain. Schmidt R.F. Willis W.D. Springer York, pp. 2617-2619. Borowczyk J.M. 2007. Visceral Referred Pain. In: Encyclopedia of Pain. Schmidt R.F. Willis W.D. Springer York, pp. 2645-2647.

Journal – Research Article Harding, G. and Yelland M. (2007). Back, chest and abdominal paint - Is it spinal referred pain? Australian Family Physician. 36(6), 422-429. Hosman, A. H., Mason, R. B., Hobbs, T., & Rothwell, A. G. (2007). A New Zealand national joint registry review of 202 total ankle replacements followed for up to 6 years. Acta Orthopaedica, 78(5), 584-591. Jenks, K.A., Stamp, L.K., O’Donnell, J.L., Savage R.L., and Chapman P.T.. (2007). Leflunomide-Associated Infections in Rheumatoid Arthritis. The Journal of Rheumatology, 34(11), 2201-2203. O’Donnell J.L. Hayman, M.W., Spellerberg, M.B., McLellan, A.D., Brooksbank, K., Chapman, P.T., Stamp. L.K. (2007). Antineutrophil cytoplasmic antibody measurement: advantages and disadvantages of a capture PR3 ELISA and a direct PR3 ELISA. Pathology,39(2): 258-263. Thwaites, J. H., Mann, F., Gilchrist, N., McKie, J., & Sainsbury, R. (2007). Older patients with hip fractures: Evaluation of a long-term specialist orthopaedic medicine service in their outcomes. The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/journal/120-1254/2535/

Commissioned Report Rothwell, A, Hobbs, T, Frampton, C. 2007. National Joint Registry Eight Year Report – January 1999 to December 2006.

Division of HEALTH SCIENCES 169 UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PAEDIATRICS

Journal – Research Article Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Darlow, B. A. (2007). Infants admitted to a neonatal intensive care unit: Parental psychological status at 9 months. Acta Paediatrica, 96, 1286-1289. Crowther, C. A., Doyle, L. W., Haslam, R. R., Hiller, J. E., Harding, J. E., Robinson, J. S., for the ACTORDS Study Group, including Reid, R., Austin, N., Darlow, B. A., Poad, D., Broadbent, R., Wilson, D. D., Sangalli, M., Elder, D., & Richardson, V. (2007). Outcomes at 2 years of age after repeat doses of antenatal corticosteroids. New England Journal of Medicine, 357(12), 1179-1189. Darlow, B. A., & Graham, P. J. (2007). Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants [Intervention Review]. Cochrane Database of Systematic Reviews, 4, CD000501. Epton, M. J., Town, G. I., Ingham, T., Wickens, K. L., Fishwick, D., Crane, J., the New Zealand Asthma and Allergy Birth Cohort Study Group, including Duignan, M., Fitzharris, P., Kelly, R., Lampshire, P., Leadbitter, P., Nicholson, A., Pattemore, P. K., Siebers, R. W., Silvers, K. M., & Withell, K. A. (2007). The New Zealand Asthma and Allergy Cohort Study (NZA2CS): Assembly, demographics and investigations. BMC Public Health, 7(26), 26. http://www.biomedcentral.com/1471- 2458/7/26 Kim, J., Beasley, S. W., & Maoate, K. (2006). Appendicostomy stomas and antegrade colonic irrigation after laparoscopic antegrade continence enema. Journal of Laparoendoscopic & Advanced Surgical Techniques, 16(4), 400-403. Mandhan, P. L., Samarakkody, U., Brown, S., Kukkady, A., Maoate, K., Blakelock, R., & Beasley, S. (2006). Comparison of suture ligation and clip application for the treatment of patent ductus arteriosus in preterm neonates. Journal of Thoracic and Cardiovascular Surgery, 132, 672-674. Mandhan, P., Quan, Q. B., Beasley, S., & Sullivan, M. (2006). Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. Journal of Pediatric Surgery, 41, 2041-2045. Mandhan, P., Sullivan, M., Quan, Q. B., & Beasley, S. (2007). The contribution of the sonic hedgehog cascade in the development of the enteric nervous system in fetal rats with anorectal malformations. Journal of Pediatric Surgery, 42, 2080-2085. Pearce, N., Aït-Khaled, N., Beasley, R., Mallol, J., Keil, U., Mitchell, E., Robertson, C., ISAAC Phase Three Study Group, including Moyes, C., & Pattemore, P. (2007). Worldwide trends in the prevalence of asthma symptoms: Phase III of the International Study of Asthma and Allergies in Childhood (ISAAC). Thorax, 62, 758-766. Somerville, R. L., Grant, C. C., Grimwood, K., Murdoch, D., Graham, D., Jackson, P., Meates-Dennis, M-A., Nicholson, R. A., & Purvis, D. (2007). Infants hospitalised with pertussis: Estimating the true disease burden. Journal of Paediatrics and Child Health, 43, 617-622.

Journal – Research Other Arsi´ c, D., Beasley, S. W., & Sullivan, M. J. (2007). Switched-on Sonic hedgehog: A gene whose activity extends beyond fetal development – to oncogenesis. Journal of Paediatrics and Child Health, 43, 421-423. Carter, J. D., Mulder, R. T., & Darlow, B. A. (2007). Parental stress in the NICU: The influence of personality, psychological, pregnancy and family factors. Personality and Mental Health, 1, 40-50. Espiner, E. A., Prickett, T. C., Yandle, T. G., Barrell, G. K., Wellby, M., Sullivan, M. J., & Darlow, B. A. (2007). ABCs of natriuretic peptides: Growth. Hormone Research, 67(Suppl. 1), 81-90. Evans, N., Hutchinson, J., Simpson, J. M., Donoghue, D., Darlow, B. A., Henderson-Smart, D., for the Australian and New Zealand Neonatal Network, including Austin, N., Broadbent, R., & Richardson, V. (2007). Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network. Archives of Disease in Childhood – Fetal and Neonatal Edition, 92, F34-F40.

Journal – Professional & Other Non-Research Articles Pattemore, P. K. (2007). Persistent cough in children. New Zealand Family Physician, 34(6), 432-436.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PATHOLOGY

Authored Book – Research Pollard, A. J., & Murdoch, D. R. (2007). Bergmedizin (3 ed.). Bern, Switzerland: Verlag Huber Hans, 240p.

Chapter in Book – Research Green, J. N., Winterbourn, C. C., & Hampton, M. B. (2007). Analysis of neutrophil bactericidal activity. In M. T. Quinn, F. R. DeLeo & G. M. Bokoch (Eds.), Methods in Molecular Biology, Volume 412: Neutrophil Methods and Protocols (pp. 319- 332). Totowa, NJ, USA: Humana Press.

170 RESEARCH REPORT 2007/2008 Journal – Research Article Abera, A. B., Marais, D., Raal, F. J., Leisegang, F., Jones, S., George, P., & Henderson, H. E. (2007). Autosomal recessive hypercholesterolaemia: Discrimination of ARH protein and LDLR function in the homozygous FH phenotype. Clinica Chimica Acta, 378, 33-37. Adeniran, A. J., & Stanek, J. (2007). Amnion nodosum revisited: Clinicopathologic and placental correlations. Archives of Pathology and Laboratory Medicine, 131(12), 1829-1833. Andreou, A. M., Pauws, E., Jones, M. C., Singh, M. K., Bussen, M., Doudney, K., Moore, G. E., Kispert, A., Brosens, J. J., & Stanier, P. (2007). TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression. The American Journal of Human Genetics, 81, 700-712. Åkerström, B., Maghzal, G. J., Winterbourn, C. C., & Kettle, A. J. (2007). The lipocalin alpha (1)-microglobulin has radical scavenging activity. Journal of Biological Chemistry, 282(43), 31493-31503. Atkinson, W., Downer, P., Lever, M., Chambers, S. T., & George, P. M. (2007). Effects of orange juice and proline betaine on glycine betaine and homocysteine in healthly male subjects. European Journal of Nutrition, 46, 446-452. Beaglehole, B., Luty, S. E., Mulder, R. T., Kennedy, M. A., & Joyce, P. R. (2007). Low red cell folate levels are associated with poor response to nortriptyline in major depression. Acta Neuropsychiatrica, 19, 204-207. Brennan, S. O., Davis, R. L., Mosesson, M. W., Hernandez, I., Lowen, R., & Alexander, S. J. (2007). Congenital hypodysfibrinogenaemia (Fibrinogen Des Moines) due to a gamma 320Asp deletion at the Ca2+ binding site. Thrombosis & Haemostasis, 98, 467-469. Brune, M., Castaigne, S., Catalano, J., Gehlsen, K., Ho, A. D., Hofmann, W-K., Hogge, D. E., Nilsson, B., Or, R., Romero, A. I., Rowe, J. M., Simonsson, B., Spearing, R., et al. (2006). Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: Results of a randomized phase 3 trial. Blood, 108(1), 88-96. Chambers, S. T., Pithie, A., Gallagher, K., Liu, T., Charles, C. J., & Seaward, L. M. (2007). Treatment of Staphylococcus epidermidis central vascular catheter infection with 70% ethanol locks: Efficacy in a sheep model. Journal of Antimicrobial Chemotherapy, 59, 779-782. Chao, C. Y., Florkowski, C. M., Fink, J. N., Southby, S. J., & George, P. M. (2007). Prospective validation of cerebrospinal fluid bilirubin in suspected subarachnoid haemorrhage. Annals of Clinical Biochemistry, 44(2), 140-144. Cox, A. G., & Hampton, M. B. (2007). Bcl-2 over-expression promotes genomic instability by inhibiting apoptosis of cells exposed to hydrogen peroxide. Carcinogenesis, 28(10), 2166-2171. Davis, R. L., & Brennan, S. O. (2007). Fibrinogen Tolaga Bay: A novel gamma Ala341 Val mutation causing hypofibrinogenaemia. Journal of Thrombosis and Haemostasis, 98, 1136-1138. Dear, A., Brennan, S., Sheat, J. M., Faed, J. M., & George, P. M. (2007). Acquired dysfibrinogenemia caused by monoclonal production of immunoglobulin light chain. Haematologica, 92, e111-e117. Dunlevy, L. P. E., Chitty, L. S., Burren, K. A., Doudney, K., Stojilkovic-Mikic, T., Stanier, P., Scott, R., Copp, A. J., & Green, N. D. E. (2007). Abnormal folate metabolism in foetuses affected by neural tube defects. Brain, 130, 1043-1049. Evans, G. E., Anderson, T. P., Seaward, L. M., & Murdoch, D. R. (2007). Evaluation of the Mycoplasma Duo kit for the dection of Mycoplasma hominis and Ureaplasma urealyticum from urogenital and placental specimens. British Journal of Biomedical Science, 64(2), 66-69. Ganly, P. S., Hanrahan, V., Baker, B., & Romeril, K. (2007). Identification of JAK2V617F in patients with polycythemia is highly correlated with conventional criteria for diagnosis of polycythemia vera. American Journal of Hematology, 82, 80-82. Gearry, R. B., Roberts, R. L., Burt, M. J., Frampton, C. M., Chapman, B. A., Collett, J., Shirley, P., Allington, M. D. E., Kennedy, M. A., & Barclay, M. L. (2007). Effect of inflammatory bowel disease classification changes on NOD2 genotype-phenotype associations in a population-based cohort. Inflammatory Bowel Diseases, 13(10), 1220-1227. Gunningham, S. P., Currie, M. J., Morrin, H. R., Tan, E. J., Turley, H., Dachs, G. U., Watson, A. I., Frampton, C., Robinson, B. A., & Fox, S. B. (2007). The angiogenic factor thymidine phosphorylase up-regulates the cell adhension molecule P-selectin in human vascular endothelial cells and is asociated with P-selectin expression in breast cancers. Journal of Pathology, 212, 335-344. Jamieson, H. A., Cogger, V. C., Twigg, S. M., McLennan, S. V., Warren, A., Cheluvappa, R., Hilmer, S. N., Fraser, R., de Cabo, R., & Le Couteur, D. G. (2007). Alterations in liver sinusoidal endothelium in a baboon model of type 1 diabetes. Diabetologia, 50, 1969-1976. Jamieson, H. A., Hilmer, S. N., Cogger, V. C., Warren, A., Cheluvappa, R., Abernethy, D. R., Everitt, A. V., Fraser, R., de Cabo, R., & Le Couteur, D. G. (2007). Caloric restriction reduces age-related pseudocapillarization of the hepatic sinusoid. Experimental Gerontology, 42(4), 374-378. Johnstone, A. C., Lea, R. A., Brennan, K. A., Schenk, S., Kennedy, M. A., & Fitzmaurice, A. (2007). Benzylpiperazine: A drug of abuse? [Review]. Journal of Psychopharmacology, 21, 888-894. Joyce, P. R., Light, K. J., Rowe, S. L., & Kennedy, M. A. (2007). Bipolar disorder not otherwise specified: Comparison with bipolar disorder I/II and major depression. Australian and New Zealand Journal of Psychiatry, 41, 843-849. Kettle, A. J., Anderson, R. F., Hampton, M. B., & Winterbourn, C. C. (2007). Reactions of superoxide with myeloperoxidase. Biochemistry, 46, 4888-4897. Lalani, T., Person, A. K., Hedayati, S. S., Moore, L. G., Murdoch, D. R., Hoen, B., Peterson, G., Shahbaz, H., Raoult, D., Miro, J. M., The International Collaboration on Endocarditis Merged Database Study Group, et al. (2007). Propionibacterium endocarditis: A case series from the international collaboration on endocarditis merged database and prospective cohort study. Scandinavian Journal of Infectious Diseases, 39, 840-848.

Division of HEALTH SCIENCES 171 Laurie, A. D., Sheen, C. R., Hanrahan, V., Smith, M. P., & George, P. M. (2007). The molecular aetiology of haemophilia A in a New Zealand patient group. Haemophilia, 13, 420-427. Laurie, A. D., Smith, M. P., & George, P. M. (2007). Detection of Factor VIII gene mutations by high-resolution melting analysis. Clinical Chemistry, 53(12), 2211-2214. Le Couteur, D. G., Cogger, V. C., McCuskey, R. S., De Cabo, R., Smedsrød, B., Sorensen, K. K., Warren, A., & Fraser, R. (2007). Age-realted changes in the liver sinusoidal endothelium. Annals of the New York Academy of Sciences, 1114, 79-87. Lever, M., Atkinson, W., George, P. M., & Chambers, S. T. (2007). An abnormal urinary excretion of glycine betaine may persist for years. Clinical Biochemistry, 40, 798-801. Lever, M., Atkinson, W., George, P. M., & Chambers, S. T. (2007). Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic. Clinical Biochemistry, 40, 1225-1231. Lever, M., Atkinson, W., Sizeland, P. C. B., Chambers, S. T., & George, P. M. (2007). Inter- and intra-individual variations in normal urinary glycine betaine excretion. Clinical Biochemistry, 40, 447-453. Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency. Biochimie, 89, 21-29. Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Carter, J. D., Frampton, C. M. A., Miller, A. L., & Kennedy, M. A. (2007). An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behavioural and Brain Functions, 3(3). http://www. behavioralandbrainfunctions.com/content/3/1/3 Low, F. M., Hampton, M. B., Peskin, A. V., & Winterbourn, C. C. (2007). Peroxiredoxin 2 functions as a noncatalytic scavenger of low-level hydrogen peroxide in the erythrocyte. Blood, 109(6), 2611-2617. Metcalf, V. J., George, P. M., & Brennan, S. O. (2007). Lungfish albumin is more similar to tetrapod than to teleost albumins: Purification and characterisation of albumin from the Australian lungfish, Neoceratodus forsteri. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 147, 428-437. Meyer, M., Dietzel, H., Kaetzel, R., Schmidt, D., Liebscher, K., & Brennan, S. O. (2007). Fibrinogen Leipzig II (gamma 351Gly→Ser and gamma 82Ala→Gly): Hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain. Thrombosis & Haemostasis, 98(4), 903-905. Mocatta, T. J., Pilbrow, A. P., Cameron, A. V., Senthilmohan, R., Frampton, C. M., Richards, A. M., & Winterbourn, C. C. (2007). Plasma concentrations of myeloperoxidase predict mortality after myocardial infarction. Journal of the American College of Cardiology, 49(20), 1993-2000. Molyneux, S., Florkowski, C. M., McGrane, Y., Lever, M., & George, P. M. (2007). Concentration response to the coenzyme Q10 supplement Q-Gel in human volunteers. Nutrition Research, 27, 307-312. Morpeth, S., Murdoch, D. R., Cabell, C. H., Karchmer, A. W., Pappas, P., Levine, D., Nacinovich, F., Tattevin, P., Fernández- Hidalgo, N., Dickerman, S. The International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators, et al. (2007). Non-NACEK gram-negative bacillus endocarditis. Annals of internal Medicine, 147(12), 829-835. Nieto, Y., Patton, N., Hawkins, T., Spearing, R., Bearman, S. I., Jones, R. B., Shpall, E. J., Rabinovitch, R., Zeng, C., Barón, A., & McSweeney, P. A. (2006). Tacrolimus and mycophenolate mofetil after nonmyeloablative matched-sibling donor allogeneic stem-cell transplantations conditioned with fludarabine and low-dose total body irradiation. Biology of Blood and Marrow Transplantation, 12, 217-225. O’Donnell, J. L., Hayman, M. W., Spellerberg, M. B., McLellan, A. D., Brooksbank, K., Chapman, P. T., & Stamp, L. K. (2007). Antineutrophil cytoplasmic antibody measurement: Advantages and disadvantages of a capture PR3 ELISA and a direct PR3 ELISA. Pathology, 39(2), 258-263. O’Donnell, J. L., Stevanovic, V. R., Frampton, C. M., Stamp, L. K., & Chapman, P. T. (2007). Wegener’s granulomatosis in New Zealand: Evidence for a latitude-dependent incidence gradient. Internal Medicine Journal, 37, 242-246. Peskin, A. V., Low, F. M., Paton, L. N., Maghzal, G. J., Hampton, M. B., & Winterbourn, C. C. (2007). The high reactivity of peroxiredoxin 2 with H2O2 is not reflected in its reaction with other oxidants and thiol reagents. Journal of Biological Chemistry, 282(16), 11885-11892. Plowman, J. E., Paton, L. N., & Bryson, W. G. (2007). The differential expression of proteins in the cortical cells of wool and hair fibres. Experimental Dermatology, 16, 707-714. Roberts, R., Gearry, R. B., Hollis-Moffatt, J. E., Miller, A. L., Reid, J., Abkevich, V., Timms, K. M., Gutin, A., Lanchbury, J. S., Merriman, T. R., Barclay, M. L., & Kennedy, M. A. (2007). IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn’s disease in a study of New Zealand Caucasians with inflammatory bowel disease. American Journal of Gastroenterology, 102, 2754-2761. Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). IMPDH1 promoter mutations in a patient exhibiting azathioprine resistence. The Pharmacogenomics Journal, 7(5), 312-317. Schmidt, D., & Brennan, S. O. (2007). Modified form of the fibrinogen betaB chain (des-Gln B beta), a potential long-lived marker of pancreatitis. Clinical Chemistry, 53(12), 2105-2111. Sheen, C. R., Jewell, U., Morris, C. M., Brennan, S. O., Férec, C., George, P. M., Smith, M. P., & Chan, J-M. (2007). Double complex mutations involving F8 and FUND2 caused by distinct break-induced replication. Human Mutation, 28(12), 1198-1206. Sies, C., Cadwallader, J., Florkowski, C. M., Woods, S. H., & George, P. M. (2007). Quartz renal calculi: Were we being led up the garden path? Annals of Clinical Biochemistry, 44, 312-314. Slow, S., Vasudevamurthy, M. K., Fraser, R., McEntyre, C. J., Lever, M., Chambers, S. T., & George, P. M. (2007). Dimethylthetin treatment causes diffuse alveolar lung damage: A pilot study in a sheep model of Continuous Ambulatory Peritoneal Dialysis (CAPD). Experimental and Toxicologic Pathology, 58, 285-290.

172 RESEARCH REPORT 2007/2008 Smit, M., Beynon, K. A., Murdoch, D. R., & Jennings, L. C. (2007). Comparison of the NOW influenza A & B, NOW Flu A, NOW Flu B, and Directigen Flu A+B assays, and immunofluorescence with viral culture for the detection of influenza A and B viruses. Diagnostic Microbiology and Infectious Disease, 57, 67-70. Somerville, R. L., Grant, C. C., Grimwood, K., Murdoch, D., Graham, D., Jackson, P., Meates-Dennis, M-A., Nicholson, R. A., & Purvis, D. (2007). Infants hospitalised with pertussis: Estimating the true disease burden. Journal of Paediatrics and Child Health, 43, 617-622. Stanek, J., & Drummond, Z. (2007). Occult placenta accreta: The missing link in the diagnosis of abnormal placentation. Pediatric and Developmental Pathology, 10(4), 266-273. Tennent, G. A., Brennan, S. O., Stangou, A. J., O’Grady, J. F., Hawkins, P. N., & Pepys, M. B. (2007). Human plasma fibrinogen is synthesized in the liver. Blood, 109(5), 1971-1974. Testro, A. G., Brennan, S. O., MacDonell, R. A. L., Hawkins, P. N., & Angus, P. W. (2007). Hereditary amyloidosis with progressive peripheral neuropathy associated with apolipoprotein A1 Gly26Arg: Outcome of hepatorenal transplantation. Liver Transplantation, 13, 1028-1031. Vella-Brincat, J. W. A., Begg, E. J., Kirkpatrick, C., Zhang, M., Chambers, S. T., & Gallagher, K. (2007). Protein binding of cefazolin is saturable in vivo both between and within patients. British Journal of Clinical Pharmacology, 63(6), 753-757. Vissers, M. C. M., Gunningham, S. P., Morrison, M. J., Dachs, G. U., & Currie, M. J. (2007). Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate. Free Radical Biology & Medicine, 42, 765-772. Vissers, M. C. M., & Wilkie, R. P. (2007). Ascorbate deficiency results in impaired neutrophil apoptosis and clearance and is associated with up-regulation of hypoxia-inducible factor 1 alpha. Journal of Leukocyte Biology, 81, 1236-1244. Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics and Cytogenetics, 178, 94-103. Warren, A., Bertolino, P., Benseler, V., Fraser, R., McCaughan, G. W., & Le Couteur, D. G. (2007). Marked changes of the hepatic sinusoid in a transgenic mouse model of acute immune-mediated hepatitis. Journal of Hepatology, 46, 239-246. Wilkie, R. P., Vissers, M. C., Dragunow, M., & Hampton, M. B. (2007). A functional NADPH oxidase prevents caspase involvement in the clearance of phagocytic neutrophils. Infection and Immunity, 75(7), 3256-3263.

Journal – Research Other Brennan, S. O., Chan, T., & Beard, M. (2007). Hemoglobin Hagley Park: A novel (〈82Ala→Thr) substitution identified in an infant with severe hemolytic anemia [Letter to the editor]. Clinical Chemistry, 53(9), 1718-1719. Brennan, S. O., Chan, T., & Sheen, C. (2007). Novel hemoglobin (Hb Grey Lynn) substitution (〈91Leu→Phe) affects heme interactions and 〈1 beta 2 contacts. Clinical Chemistry, 53(5), 990-991. Davis, R. L., Mosesson, M. W., Kerlin, B. A., Canner, J. A., Ruymann, F. B., & Brennan, S. O. (2007). Fibrinogen Columbus: A novel gamma Gly200Val mutation causing hypofibrinogenemia in a family with associated thrombophilia [Letters to the editor]. Haematologica, 92(8), 1151-1152. Favaloro, E. J., Patterson, D., Denholm, A., Mead, S., Gilbert, A., Collins, A., Estell, J., George, P. M., & Smith, M. P. (2007). Differential identification of a rare form of platelet-type (pseudo-) von Willebrand disease (VWD) from Type 2B VWD using a simplified ristocetin-induced-platelet-agglutination mixing assay and confirmed by genetic analysis [Correspondence]. British Journal of Haematology, 139, 621-628. Gardiner, S. J., Gearry, R. B., Roberts, R., Zhang, M., Barclay, M. L., & Begg, E. J. (2007). Comment: Breast-feeding during maternal use of azathioprine [Letter to the editor]. The Annals of Pharmacotherapy, 41(4), 719-720. Hammer, D. A., Dongol, S., Anderson, T. P., Wong, J. S. J., Werno, A. M., & Murdoch, D. R. (2007). High prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae in Nepal [Letters to the editor]. International Journal of Antimicrobial Agents, 30, 469-474. Homer, V. M., & George, P. M. (2007). Novel mutation (c.G1124A) in Exon 9 of the APOB gene causes aberrant splicing and familial hypobetallpoproteinimia [Letter to the editor]. Clinical Chemistry, 53(6), 1165-1167. Kennedy, M. A. (2007). Pharmacogenomics: Single genes, whole genomes and global networks. Personalized Medicine, 4(1), 87-94. Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the Editor]. Molecular Psychiatry, 12, 899-900. Molyneux, S., Lever, M., Florkowski, C. M., & George, P. M. (2007). Plasma total coenzyme Q9 (CoQ9) in the New Zealand population: Reference interval and biological variation [Letter]. Clinical Chemistry, 53(4), 802-803. Saravanan, L., Brennan, S., George, P. M., Lowen, R., Kirkland, M., & Campbell, P. (2007). Novel fibrinogen A alpha chain mutation associated with afibrinogenaemia [Corrrespondence]. Pathology, 39(5), 519-535. Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., George, P. M., & Scott, R. S. (2007). Effect of coenzyme Q10 supplementation on simvastatin-induced myalgia. The American Journal of Cardiology, 100, 1400-1403.

Journal – Professional & Other Non-Research Articles Huggan, P. J., & Murdoch, D. R. (2007). Vancomycin therapy for severe Clostridium difficile-associated diarrhea [Correspondence]. Clinical Infectious Diseases, 45, 1647-1648. Liew, O. W., Chong, P. C. J., Lim, Y. Z., Ang, C. X., Lau, Y. C. A., Yandle, T. G., & Brennan, S. O. (2007). [Erratum to “An SRLLR motif downstream of the scissile bond enhances enterokinase cleavage efficiency” [Biochimie 89 (2007) 21-29]]. Biochimie, 89, 1438.

Division of HEALTH SCIENCES 173 Intellectual Property Roberts, R. L., Gearry, R. B., Barclay, M. L., & Kennedy, M. A. (2007). Method of identifying individuals at risk of thiopurine drug resistance and intolerance. (60/935367).

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Chapter in Book – Research Beautrais, A. L., & Wells, J. E. (2006). Suicidal behaviour. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 67-79). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Goldney, R., & Beautrais, A. L. (2007). Suicide and suicidal behaviour. In S. Bloch & B. S. Singh (Eds.), Foundations of clinical psychiatry (Third ed.). (pp. 523-537). Melbourne University Press. McIntosh, V. V. W., Jordan, J., Carter, J. D., Latner, J. D., & Wallace, A. (2007). Appetite-focused cognitive-behavioral therapy for binge eating. Self-help approaches for obesity and eating disorders: Research and practice (pp. 325-346). New York: Guildford Press.

Chapter in Book – Textbook & Other Beautrais, A. L., & Surgenor, L. J. (2007). Suicidal behaviour and practitioner issues. In I. M. Evans, J. J. Rucklidge, M. O’Driscoll (Ed.), Professional practice of psychology in Aotearoa New Zealand (pp. 195-210). Wellington, New Zealand: New Zealand Psychological Society. Surgenor, L. J., & Complaints and Discipline Committee New Zealand Psychologists Board (2007). Accountability and the complaint process. In I. M. Evans, J. J. Rucklidge, & M. O’Driscoll (Eds.), Professional practice of psychology in Aotearoa New Zealand (pp. 367-376). Wellington, New Zealand: New Zealand Psychological Society.

Journal – Research Article Andriessen, K., Beautrais, A. L., Grad, O. T., Brockmann, E., & Simkin, S. (2007). Current understandings of suicide survivor issues: Research, practice, and plans: Report of the 1st International Suicide Postvention Seminar, September 8, 2006, Portoroz, Slovenia. Crisis, 28(4), 211-213. Beaglehole, B., Luty, S. E., Mulder, R. T., Kennedy, M. A., & Joyce, P. R. (2007). Low red cell folate levels are associated with poor response to nortriptyline in major depression. Acta Neuropsychiatrica, 19, 204-207. Beautrais, A., Fergusson, D., Coggan, C., Collings, C., Doughty, C., Ellis, P., Hatcher, S., Horwood, J., Merry, S., Mulder, R., Poulton, R., & Surgenor, L. (2007). Effective strategies for suicide prevention in New Zealand: A review of the evidence. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2459/ Beautrais, A. L. (2007). Suicide by jumping: A review of research and prevention strategies. Crisis, 28(Suppl. 1), 58-63. Boden, J., Fergusson, D. M., & Horwood, L. J. (2007). Self-esteem and violence: Testing links between adolescent self-esteem and later hostility and violent behavior. Social Psychiatry and Psychiatric Epidemiology, 42, 881-891. Boden, J. M., Fergusson, D. M., & Horwood, L. J. (2007). Anxiety disorders and suicidal behaviours in adolescence and young adulthood: Findings from a longitudinal study. Psychological Medicine, 37, 431-440. Boden, J. M., Horwood, L. J., & Fergusson, D. M. (2007). Exposure to childhood sexual and physical abuse and subsequent educational achievement outcomes. Child Abuse & Neglect, 31, 1101-1114. Carter, F. A., Carter, J. D., Luty, S. E., Jordan, J., McIntosh, V. V. W., Bartram, A. F., Mulder, R. T., McKenzie, J. M., & Bulik, C. M. (2007). What is worse for your sex life: Starving, being depressed, or a new baby? International Journal of Eating Disorders, 40, 664-667. Carter, J. D., Mulder, R. T., Frampton, C. M. A., & Darlow, B. A. (2007). Infants admitted to a neonatal intensive care unit: Parental psychological status at 9 months. Acta Paediatrica, 96, 1286-1289. Crowe, M. T., & Carlyle, D. (2007). Mental health nursing research: The contemporary context: Feature Article. International Journal of Mental Health Nursing, 16(5), 365-370. Edgar, P. F., Hooper, A. J., Poa, N. R., & Burnett, J. R. (2007). Violent behavior associated with hypocholesterolemia due to a novel APOB gene mutation. Molecular Psychiatry, 12, 258-263. Evans, C., Ehlers, A., Mezey, G., & Clark, D. M. (2007). Intrusive memories and ruminations related to violent crime among young offenders: Phenomenological characteristics. Journal of Traumatic Stress, 20(2), 183-196. Fergusson, D. M., Boden, J., & Horwood, L. J. (2007). Recurrence of major depression in adolescence and early adulthood, and later mental health, educational and economic outcomes. British Journal of Psychiatry, 191, 335-342. Fergusson, D. M., Boden, J. M., & Horwood, J. (2007). Exposure to single parenthood in childhood and later mental health, educational, economic, and criminal behavior outcomes. Archives of General Psychiatry, 64(9), 1089-1095. Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2007). Unemployment and suicidal behavior in a New Zealand birth cohort: A fixed effects regression analysis. Crisis: The Journal of Crisis Intervention and Suicide Prevention, 28(2), 95-101. Fergusson, D. M., Horwood, L. J., Boden, J. M., & Jenkin, G. (2007). Childhood social disadvantage and smoking in adulthood: Results of a 25-year longitudinal study. Addiction, 102(3), 475-482.

174 RESEARCH REPORT 2007/2008 Fergusson, D. M., Horwood, L. J., & Ridder, E. M. (2007). Conduct and attentional problems in childhood and adolescence and later substance use, abuse and dependence: Results of a 25-year longitudinal study. Drug and Alcohol Dependence, 88S, S14-S26. Fergusson, D. M., Vitaro, F., Wanner, B., & Brendgen, M. (2007). Protective and compensatory factors mitigating the influence of deviant friends on delinquent behaviours during early adolescence. Journal of Adolescence, 30, 33-50. Gallagher, P., Robinson, L. J., Gray, J. M., Porter, R. J., & Young, A. H. (2007). Neurocognitive function following remission in major depressive disorder: Potential objective marker of response? Australian and New Zealand Journal of Psychiatry, 41, 54-61. Harvey, M. A., Sellman, J. D., Porter, R. J., & Frampton, C. M. (2007). The relationship between non-acute adolescent cannabis use and cognition. Drug and Alcohol Review, 26, 309-319. Joyce, P. R., Light, K. J., Rowe, S. L., & Kennedy, M. A. (2007). Bipolar disorder not otherwise specified: Comparison with bipolar disorder I/II and major depression. Australian and New Zealand Journal of Psychiatry, 41, 843-849. Joyce, P. R., McKenzie, J. M., Carter, J. D., Rae, A. M., Luty, S. E., Frampton, C. M. A., & Mulder, R. T. (2007). Temperament, character and personality disorders as predictors of response to interpersonal psychotherapy and cognitive-behavioural therapy for depression. British Journal of Psychiatry, 190, 503-508. Joyce, P. R., Williamson, S. A. H., McKenzie, J. M., Frampton, C. M. A., Luty, S. E., Porter, R. J., & Mulder, R. T. (2007). Effects of childhood experiences on cortisol levels in depressed adults. Australian and New Zealand Journal of Psychiatry, 41, 62-65. Light, K. J., Joyce, P. R., Luty, S. E., Mulder, R. T., Carter, J. D., Frampton, C. M. A., Miller, A. L., & Kennedy, M. A. (2007). An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behavioural and Brain Functions, 3(3). http://www. behavioralandbrainfunctions.com/content/3/1/3 Liu, K. Y., Beautrais, A. L., Caine, E., Chan, K., Chao, A., Conwell, Y., Law, C., Lee, D., Li, P., & Yip, P. (2007). Charcoal burning suicides in Hong Kong and urban Taiwan: An illustration of the impact of a novel suicide method on overall regional rates. Journal of Epidemiology and Community Health, 61, 248-253. Luty, S. E., Carter, J. D., McKenzie, J. M., Rae, A. M., Frampton, C. M. A., Mulder, R. T., & Joyce, P. R. (2007). Randomised controlled trial of interpersonal psychotherapy and cognitive-behavioural therapy for depression. British Journal of Psychiatry, 190, 496-502. Moor, S., Maguire, A., McQueen, H., Wells, E. J., Elton, R., Wrate, R., & Blair, C. (2007). Improving the recognition of depression in adolescence: Can we teach the teachers? Journal of Adolescence, 30, 81-95. Pitama, S., Robertson, P., Cram, F., Gillies, M., Huria, T., & Dallas-Katoa, W. (2007). Meihana model: A clinical assessment framework. New Zealand Journal of Psychology, 36(3), 118-125. Poa, N. R., & Edgar, P. F. (2007). Insulin resistance is associated with hypercortisolemia in polynesian patients treated with antipsychotic medication. Diabetes Care, 30(6), 1425-1429. Porter, R. J., Gallagher, P., & O’Brien, J. T. (2007). Effects of rapid tryptophan depletion on salivary cortisol in older people recovered from depression, and the healthy elderly. Journal of Psychopharmacology, 21(1), 71-75. Sambeth, A., Blokland, A., Harmer, C. J., Kilkens, T. O. C., Nathan, P. J., Porter, R. J., Schmitt, J. A. J., Scholtissen, B., Sobczak, S., Young, A. H., & Riedel, W. J. (2007). Sex differences in the effect of acute tryptophan depletion on declarative episodic memory: A pooled analysis of nine studies. Neuroscience and Biobehavioral Reviews, 31, 516-529. Soh, N. L-W., Touyz, S., Dobbins, T. A., Surgenor, L. J., Clarke, S., Kohn, M. R., Lee, E. L., Leow, V., Rieger, E., Ung, K. E. K., & Walter, G. (2007). Restraint and eating concern in North European and East Asian women with and without eating disorders in Australia and Singapore. Australian and New Zealand Journal of Psychiatry, 41(6), 536-545. Soh, N., Surgenor, L. J., Touyz, S., & Walter, G. (2007). Eating disorders across two cultures: Does the expression of psychological control vary? Australian and New Zealand Journal of Psychiatry, 41, 351-358. Surgenor, L. J., Maguire, S., Russell, J., & Touyz, S. (2007). Self-liking and self-competence: Relationship to symptoms of anorexia nervosa. European Eating Disorders Review, 15, 139-145. Turner, M., Smith-Hamel, C., & Mulder, R. T. (2007). Prediction of twelve-month service disengagement from an early intervention in psychosis service. Early Intervention in Psychiatry, 1, 276-281. Wells, J. E., Horwood, L. J., & Fergusson, D. M. (2007). Reasons why young adults do or do not seek help for alcohol problems. Australian and New Zealand Journal of Psychiatry, 41, 1005-1012. Woodward, L. J., Fergusson, D. M., Chesney, A., & Horwood, L. J. (2007). Punitive parenting practices of contemporary young parents. The New Zealand Medical Journal, 120(1267). http://www.nzma.org.nz/journal/120-1267/2866/

Journal – Research Other Beautrais, A. (2007). Looking back on 2007 [Editorial]. Crisis, 28(4), 159-164. Beautrais, A. L. (2007). The contribution to suicide prevention of restricting access to methods and sites [Editorial]. Crisis, 28(Suppl. 1), 1-3. Beautrais, A. L., & Mishara, B. (2007). World Suicide Prevention Day: September 10, 2007 “Suicide Prevention Across the Life Span” [Editorial]. Crisis, 28(2), 57-60. Carter, J. D., Mulder, R. T., & Darlow, B. A. (2007). Parental stress in the NICU: The influence of personality, psychological, pregnancy and family factors. Personality and Mental Health, 1, 40-50. Fergusson, D. M., Boden, J. M., & Horwood, L. J. (2007). Circumcision status and risk of sexually transmitted infection in young adult males: An analysis of a longitudinal birth cohort [Editorial comment]. Obstetrical and Gynecological Survey, 62(4), 225-226.

Division of HEALTH SCIENCES 175 Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the Editor]. Molecular Psychiatry, 12, 899-900. Moor, S., Luty, S., & Joyce, P. (2007). Lamotrigine-induced mania in adolescents. Australian and New Zealand Journal of Psychiatry, 41(12), 1013. Mulder, R. T. (2007). Suicide prevention in New Zealand [Editorial]. The New Zealand Medical Journal, 120(1251). http:// www.nzma.org.nz/journal/120-1251/2463/ Porter, R. J., Bourke, C. M., & Gallagher, P. (2007). Neuropsychological impairment in major depression: Its nature, origin and clinical significance. Australian and New Zealand Journal of Psychiatry, 41, 115-128. Sellman, J. D., Baker, M. P., Adamson, S. J., & Geering, L. G. (2007). Future of God in recovery from drug addiction. Australian and New Zealand Journal of Psychiatry, 41, 800-808. Walker, H., Porter, R. J., Ritz, S., & Beckert, L. E. (2007). Late occurrence of clozapine-associated polyserositis [Letter to the editor]. International Journal of Neuropsychopharmacology, 10, 147-148.

Journal – Professional & Other Non-Research Articles Elmslie, J. (2007). Clinical practice guidelines. A dilemma for dietitians? Nutrition and Dietetics, 64, 2-4. Joyce, P. R. (2007). Faster publication, improved impact factor and top papers [Editorial]. Australian and New Zealand Journal of Psychiatry, 41, 777-778. Joyce, P. R. (2007). The evolving neurobiology of depression: From synapses to neurons, circuits and loops [Editorial]. Australian and New Zealand Journal of Psychiatry, 41, 561-562. Mulder, R. T. (2007). Personality and depression: A commentary [Guest editorial]. Canadian Journal of Psychiatry, 53(1), 3-5.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PUBLIC HEALTH AND GENERAL PRACTICE

Edited Book – Research Wells, J. E., Baxter, J., & Schaaf, D. (Eds.). (2007). Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey. Wellington, New Zealand: Alcohol Advisory Council of New Zealand, 138p.

Chapter in Book – Research Beautrais, A. L., & Wells, J. E. (2006). Suicidal behaviour. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 67-79). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Oakley Browne, M. A., & Wells, J. E. (2006). Health services. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 79-94). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Wells, J. E. (2006). Alcohol Use Disorders Identification Test. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 95-108). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Wells, J. E., & Oakley Browne, M. A. (2006). Prevalence. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 19-48). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Wells, J. E., & Oakley Browne, M. A. (2006). The study in perspective. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 109-116). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Wells, J. E., Oakley Browne, M. A., & McGee, M. A. (2006). Introduction. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. 1-17). Wellington, New Zealand: Alcohol Advisory Council of New Zealand. Wells, J. E., Oakley Browne, M. A., & Scott, K. M. (2006). Executive summary. In J. E. Wells, J. Baxter, & D. Schaaf (Eds.), Substance use disorders in Te Rau Hinengaro: The New Zealand Mental Health Survey (pp. xxi-xxviii). Wellington, New Zealand: Alcohol Advisory Council of New Zealand.

Journal – Research Article Anderson, N. G., Jolly, I. J., & Wells, J. E. (2007). Sonographic estimation of fetal weight: Comparison of bias, precision and consistency using 12 different formulae. Ultrasound in Obstetrics and Gynecology, 30, 173-179. Beautrais, A., Fergusson, D., Coggan, C., Collings, C., Doughty, C., Ellis, P., Hatcher, S., Horwood, J., Merry, S., Mulder, R., Poulton, R., & Surgenor, L. (2007). Effective strategies for suicide prevention in New Zealand: A review of the evidence. The New Zealand Medical Journal, 120(1251). http://www.nzma.org.nz/journal/120-1251/2459/ Broadstock, M., Doughty, C., & Eggleston, M. (2007). Systematic review of the effectiveness of pharmacological treatments for adolescents and adults with autism spectrum disorder. Autism, 11(4), 335-348. Cook, L. A., Pun, A., van Vliet, H., Gallo, M. F., & Lopez, M. F. (2007). Scalpel versus no-scalpel incision for vasectomy. Cochrane Database of Systematic Reviews, (2), CD004112.

176 RESEARCH REPORT 2007/2008 Cook, L. A., van Vliet, H. H., Lopez, L. M., Pun, A., & Gallo, M. F. (2007). Vasectomy occlusion techniques for male sterilization (Review). Cochrane Database of Systematic Reviews, (2), CD003991. Darlow, B. A., & Graham, P. J. (2007). Vitamin A supplementation to prevent mortality and short and long-term morbidity in very low birthweight infants [Intervention Review]. Cochrane Database of Systematic Reviews, 4, CD000501. Graham, P. J., & Penny, R. (2007). Multiply imputed synthetic data files. Official Statistics Research Series, 1. http://www. statisphere.govt.nz/official-statistics-research/series/vol-1.htm Hider, P., Lay-Yee, R., Crampton, P., & Davis, P. F. (2007). Comparison of services provided by urban commercial, community- governed and traditional primary care practices in New Zealand. Journal of Health Services Research and Policy, 12(4), 215-222. Hider, P., Lay-Yee, R., & Davis, P. (2007). Doctors, practices, patients, and their problems during usual hours: A description of rural and non-rural primary care in New Zealand in 2001-2002. The New Zealand Medical Journal, 120(1253). http:// www.nzma.org.nz/journal/120-1253/2519/ Hider, P., Lay-Yee, R., & Davis, P. (2007). Practitioners, patients, and their visits: A description of accident and medical (A & M) clinics in New Zealand, 2001/2. The New Zealand Medical Journal, 120(1254). http://www.nzma.org.nz/ journal/120-1254/2538/ Kerr, J., Day, P., Broadstock, M., Weir, R. P., & Bidwell, S. (2007). Systematic review of the effectiveness of population screening for colorectal cancer. The New Zealand Medical Journal, 120(1258). http://www.nzma.org.nz/journal/120-1258/2629/ Malcolm, L., & Barnett, P. S. (2007). Disclosure of treatment injury in New Zealand’s no-fault compensation system. Australian Health Review, 31(1), 116-122. Mangin, D. A., Sweeney, K., & Heath, I. (2007). Preventive health care in elderly people needs rethinking. British Medical Journal, 335, 285-287. Moor, S., Maguire, A., McQueen, H., Wells, E. J., Elton, R., Wrate, R., & Blair, C. (2007). Improving the recognition of depression in adolescence: Can we teach the teachers? Journal of Adolescence, 30, 81-95. Pitama, S., Robertson, P., Cram, F., Gillies, M., Huria, T., & Dallas-Katoa, W. (2007). Meihana model: A clinical assessment framework. New Zealand Journal of Psychology, 36(3), 118-125. Richardson, S., Casey, M., & Hider, P. (2007). Following the patient journey: Older persons’ experiences of emergency departments and discharge. Accident and Emergency Nursing, 15, 134-140. Sheerin, I. G., Hamilton, G., Humphrey, A., & Scragg, A. (2007). Issues in the assessment of cardiovascular risk in selected general practices in Canterbury, New Zealand. The New Zealand Medical Journal, 120(1261). http://www.nzma.org.nz/ journal/120-1261/2714/ Smith, S., Shipton, E. A., & Wells, J. E. (2007). In-hospital cardiac arrest: Different wards show different survival patterns. Anaesthesia and Intensive Care, 35(4), 522-528. Walker, L. C., Harris, G. C., Holloway, A. J., McKenzie, G. W., Wells, J. E., Robinson, B. A., & Morris, C. M. (2007). Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. Cancer Genetics and Cytogenetics, 178, 94-103. Wang, P. S., Aguilar-Gaxiola, S., Alonso, J., Wells, J. E., et al. (2007). Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys. The Lancet, 370, 841-850. Wells, J. E., Horwood, L. J., & Fergusson, D. M. (2007). Reasons why young adults do or do not seek help for alcohol problems. Australian and New Zealand Journal of Psychiatry, 41, 1005-1012. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). Medical student characteristics associated with time in study: Is spending more time always a good thing? Medical Teacher, 29, 106-110. Wilkinson, T. J., Wells, J. E., & Bushnell, J. A. (2007). What is the educational impact of standards-based assessment in a medical degree? Medical Education, 41, 565-572. Wilson, K., Dowson, C. A., & Mangin, D. A. (2007). Prevalence of complementary and alternative medicine use in Christchurch, New Zealand: Children attending general practice versus paediatric outpatients. The New Zealand Medical Journal, 120(1251), 1-9. http://www.nzma.org.nz/journal/120-1251/2464/content.pdf

Journal – Research Other Light, K. J., Miller, A. L., Doughty, C. J., Joyce, P. R., Olds, R. J., & Kennedy, M. A. (2007). FAT and bipolar affective disorder [Letter to the Editor]. Molecular Psychiatry, 12, 899-900. Mangin, D. A., & Toop, L. J. (2007). The quality and outcomes framework: What have you done to yourselves? British Journal of General Practice, 57(539), 435-437. Mangin, D. A., & Toop, L. J. (2007). Urinary tract infection in primary care. British Medical Journal, 334, 597-598. Toop, L. J., & Mangin, D. A. (2007). Industry funded patient information and the slippery slope to New Zealand. British Medical Journal, 335, 694-695.

Journal – Professional & Other Non-Research Articles Cunningham, E. H., Cameron, V. A., Evans, J., Irvine, V., Pitama, S., & Robertson, P. (2007). The development of guidelines for handling samples and specimens collected for research involving Mäori [Letter]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2785/ Hider, P. (2007). Improving Mäori health outcomes with decision support [Editorial]. The New Zealand Medical Journal, 120(1250). http://www.nzma.org.nz/journal/120-1250/2443/ Toop, L. J., & Mangin, D. (2007). Evidence of net benefit is lacking. British Medical Journal, 335(7631), 1170.

Division of HEALTH SCIENCES 177 Weir, R. P., & Bidwell, S. (2007). Randomised controlled trial to meta-analysis ratio: A reply from a group producing systematic reviews [Letter]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2843/

Commissioned Report for External Body Abel, G. M., Fitzgerald, L. J., & Brunton, C. (2007). The impact of the Prostitution Reform Act on the health and safety practices of sex workers. Commissioned by Prostitution Law Review Committee. Christchurch, New Zealand: Department of Public Health and General Practice, University of Otago, 221p.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF RADIOLOGY

Journal – Research Article Anderson, N. G., Jolly, I. J., & Wells, J. E. (2007). Sonographic estimation of fetal weight: Comparison of bias, precision and consistency using 12 different formulae. Ultrasound in Obstetrics and Gynecology, 30, 173-179. Buckenham, T., Roake, J., Lewis, D., Gordon, M., & Wright, I. (2007). Abdominal aortic aneurysm surveillance: Application of the UK Small Aneurysm Trial to a New Zealand tertiary hospital. The New Zealand Medical Journal, 120(1251). http:// www.nzma.org.nz/journal/120-1251/2472/ Fenwick, J. L., Wright, I. A., & Buckenham, T. M. (2007). Endovascular repair of chronic mesenteric occlusive disease: The role of duplex surveillance. ANZ Journal of Surgery, 77, 60-63. Kang, A., Buckenham, T., Roake, J., & Lewis, D. (2007). Computed tomography arteriography to assess greater saphenous vein as a conduit for peripheral bypass. ANZ Journal of Surgery, 77, 870-872.

Journal – Research Other Jardine, D. L., Hurrell, M. A., & Fink, J. (2007). Tilt-test diagnosis of hypotensive transcient ischaemic attacks [Communication]. Internal Medicine Journal, 37(7), 498-501.

Journal – Professional & Other Non-Research Articles Cowan, I. A., Smith, T., Nakabea, P., Ajibulu, O., & Hennessy, O. (2007). Developing the image interpretation skills of South Pacific radiographers: A joint WHO/RANZCR/ISRRT project. Australian Radiology, 51, 527-531. Spencer, A. J., & Buckenham, T. M. (2007). Intramural haematoma of the thoracic aorta: Rupture and endoluminal exclusion. Australasian Radiology, 51, B313-B315. Stuckey, S. L., Goh, T. D., Heffernan, T., & Rowan, D. (2007). Hyperintensity in the subarachnoid space on FLAIR MRI. Neuroradiology, 189, 913-921.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF SURGERY

Chapter in Book – Textbook & Other Beasley, S. W. (2007). Esophageal atresia: Surgical aspects. In M. D. Stringer, K. T. Oldham, & P. D. E. Mouriquand (Eds.), Pediatric surgery and urology: Long-term outcomes (2nd ed.). (pp. 192-207). Cambridge University Press. Beasley, S. W. (2007). Abdominal pain and vomiting in children. In D. M. Roberton & M. South (Eds.), Practical paediatrics (6th ed.). (pp. 713-721). Edinburgh: Churchill Livingstone. Beasley, S. W. (2007). Acute neonatal surgical conditions. In D. M. Roberton & M. South (Eds.), Practical paediatrics (6th ed.). (pp. 378-382). Edinburgh: Churchill Livingstone. Beasley, S. W. (2007). Common surgical conditions in children. In D. M. Roberton & M. South (Eds.), Practical paediatrics (6th ed.). (pp. 263-272). Edinburgh: Churchill Livingstone.

Journal – Research Article Bird, P. A., Begg, E. J., Zhang, M., Keast, A. T., Murray, D. P., & Balkany, T. J. (2007). Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph. Otology & Neurotology, 28, 1124-1130. Buckenham, T., Roake, J., Lewis, D., Gordon, M., & Wright, I. (2007). Abdominal aortic aneurysm surveillance: Application of the UK Small Aneurysm Trial to a New Zealand tertiary hospital. The New Zealand Medical Journal, 120(1251). http:// www.nzma.org.nz/journal/120-1251/2472/ Elder, M., Steven, D., Beasley, S., & Wium, D. (2007). Unplanned overnight hospital admission after strabismus surgery. The New Zealand Medical Journal, 120(1260). http://www.nzma.org.nz/journal/120-1260/2681/ Gendall, K. A., Kennedy, R. R., Watson, A. J., & Frizelle, F. A. (2007). The effect of epidural analgesia on postoperative outcome after colorectal surgery. Colorectal Disease, 9(7), 584-598. Gendall, K. A., Raniga, S., Kennedy, R., & Frizelle, F. A. (2007). The impact of obesity on outcome after major colorectal surgery. Diseases of the Colon & Rectum, 50(12), 2223-2237. Ghosh, J., Eglinton, T., Frizelle, F. A., & Watson, A. J. (2007). Presacral tumours in adults. Surgeon, 5(1), 31-38.

178 RESEARCH REPORT 2007/2008 Hamill, J., & Beasley, S. W. (2007). Training in paediatric trauma: The problem of safer societies. ANZ Journal of Surgery, 76, 596-599. Heitger, M. H., Jones, R. D., Dalrymple-Alford, J. C., Frampton, C. M., Ardagh, M. W., & Anderson, T. J. (2007). Mild head injury: A close relationship between motor function at 1 week post-injury and overall recovery at 3 and 6 months. Journal of the Neurological Sciences, 253, 34-47. Heitger, M. H., Jones, R. D., Frampton, C. M., Ardagh, M. W., & Anderson, T. J. (2007). Recovery in the first year after mild head injury: Divergence of symptom status and self-perceived quality of life. Journal of Rehabilitation Medicine, 39(8), 612-621. Kandula, T., Roake, J. A., & Lewis, D. R. (2007). Vacuum assisted closure devices in the elderly: A word of caution. The New Zealand Medical Journal, 120(1263). http://www.nzma.org.nz/journal/120-1263/2752/ Kang, A., Buckenham, T., Roake, J., & Lewis, D. (2007). Computed tomography arteriography to assess greater saphenous vein as a conduit for peripheral bypass. ANZ Journal of Surgery, 77, 870-872. Kim, J., Beasley, S. W., & Maoate, K. (2006). Appendicostomy stomas and antegrade colonic irrigation after laparoscopic antegrade continence enema. Journal of Laparoendoscopic & Advanced Surgical Techniques, 16(4), 400-403. Mandhan, P. L., Samarakkody, U., Brown, S., Kukkady, A., Maoate, K., Blakelock, R., & Beasley, S. (2006). Comparison of suture ligation and clip application for the treatment of patent ductus arteriosus in preterm neonates. Journal of Thoracic and Cardiovascular Surgery, 132, 672-674. Mandhan, P., Quan, Q. B., Beasley, S., & Sullivan, M. (2006). Sonic hedgehog, BMP4, and Hox genes in the development of anorectal malformations in Ethylenethiourea-exposed fetal rats. Journal of Pediatric Surgery, 41, 2041-2045. Mandhan, P., Sullivan, M., Quan, Q. B., & Beasley, S. (2007). The contribution of the sonic hedgehog cascade in the development of the enteric nervous system in fetal rats with anorectal malformations. Journal of Pediatric Surgery, 42, 2080-2085. Moot, A. R., Ledingham, K. M., Wilson, P. F., Senthilmohan, S. T., Lewis, D. R., Roake, J., & Allardyce, R. (2007). Composition of volatile organic compounds in diathermy plume as detected by selected ion flow tube mass spectrometry. ANZ Journal of Surgery, 77, 20-23. Muthu, C., Chu, J. J., Le Heron, C., Roake, J. A., & Lewis, D. R. (2007). Patient awareness of risk factors for perpheral vascular disease. Annals of Vascular Surgery, 21(4), 433-437. Nakka, P., Chu, J., Roake, J., & Lewis, D. (2007). Variability in counselling patients regarding the hereditary nature of abdominal aortic aneurysm (AAA): Lack of evidence or resources? The New Zealand Medical Journal, 120(1251). http:// www.nzma.org.nz/journal/120-1251/2460/ Speake, D., Biyani, D., Frizelle, F. A., & Watson, A. J. (2007). Flat adenomas. ANZ Journal of Surgery, 77(1-2), 4-8. Stiven, P. N., Frampton, C. M., & Lewis, D. R. (2007). Use of autopsy in general surgery: A comparison of practice and opinion. ANZ Journal of Surgery, 77, 722-726. Toh, T., Morton, J., Coxon, J., & Elder, M. J. (2007). Medical treatment of cataract. Clinical & Experimental Ophthalmology, 35(7), 664-671. Watson, A. J., Lolohea, S., Robertson, G. M., & Frizelle, F. A. (2007). The role of positron emission tomography in the management of recurrent colorectal cancer: A review. Diseases of the Colon & Rectum, 50(1), 102-114.

Journal – Research Other Arsi´ c, D., Beasley, S. W., & Sullivan, M. J. (2007). Switched-on Sonic hedgehog: A gene whose activity extends beyond fetal development – to oncogenesis. Journal of Paediatrics and Child Health, 43, 421-423. Frizelle, F. A. (2007). [Review of the book Clinical sports medicine (third edition)]. The New Zealand Medical Journal, 120(1266). http://www.nzma.org.nz/journal/120-1266/2851/ Frizelle, F. A. (2007). [Review of the book Safety and ethics in healthcare: A guide to getting in right]. The New Zealand Medical Journal, 120(1267). http://www.nzma.org.nz/journal/120-1267/2888/ Frizelle, F. A. (2007). Peer review of NZMJ articles: Issues raised after publication of the viewpoint article on Janet Frame [Editorial]. The New Zealand Medical Journal, 120(1264). http://www.nzma.org.nz/journal/120-1264/2788/ Gearry, R. B., & Frizelle, F. A. (2007). Management of dysplasia in patients with ulcerative colitis by surgeons: Truth or speculation [Letter to the editor]. Gastrointestinal Endoscopy, 66(5), 1069-1070. Meagher, A. P., Frizelle, F. A., & Janes, S. (2007). Practice parameters for sigmoid diverticulitis [Comment]. Diseases of the Colon & Rectum, 50(5), 683-685.

Journal – Professional & Other Non-Research Articles Bird, P. A., & MacFarlane, M. R. (2007). Management of unilateral vestibular schwannoma/acoustic neuroma [Editorial]. The New Zealand Medical Journal, 120(1265). http://www.nzma.org.nz/journal/120-1265/2805/ Frizelle, F. A. (2007). Colorectal cancer in New Zealand [Editorial]. The New Zealand Medical Journal, 120(1258). http://www. nzma.org.nz/journal/120-1258/2628/ Laine, C., DeAngelis, C., Delamothe, T., Drazen, J. M., Frizelle, F. A., Haug, C., Hébert, P. C., Horton, R., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. Annals of Internal Medicine, 147(4), 275-277. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marušić, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. Croatian Medical Journal, 48(3), 289-291.

Division of HEALTH SCIENCES 179 Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Comment]. Lancet, 369(9577), 1909-1911. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. Medical Journal of Australia, 186(12), 612-613. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. The New England Journal of Medicine, 356(26), 2734-2736. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. The New England Journal of Medicine, 356(26), 2734-2736. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Commentary]. CMAJ, 177(1), 57-58. Laine, C., Horton, R., DeAngelis, C. D., Drazen, J. M., Frizelle, F. A., Godlee, F., Haug, C., Hébert, P. C., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T. V., Sox, H. C., Van Der Weyden, M. B., & Verheugt, F. W. A. (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. BMJ, 334, 1177-1178. Laine, C., Horton, R., DeAngelis, C., Drazen, J., Frizelle, F., Godlee, F., Haug, C., Hébert, P., Kotzin, S., Marusic, A., Sahni, P., Schroeder, T., Sox, H., Van Der Weyden, M., Verheugt, F., & International Committee of Medical Journal Editors (ICMJE) (2007). Clinical trial registration: Looking back and moving ahead [Editorial]. The New Zealand Medical Journal, 120(1256).

UNIVERSITY OF OTAGO, CHRISTCHURCH CENTRE FOR POSTGRADUATE NURSING STUDIES

Journal – Research Article Crowe, M. T., & Carlyle, D. (2007). Mental health nursing research: The contemporary context. International Journal of Mental Health Nursing, 16, 365-370. Ritchie, L. H. (2007). The ‘good doctor’: Older people’s perceptions. New Zealand Family Physician, 34(6), 409-412. Whitehead, L. C. (2007). Methodological and ethical issues in internet-mediated research in the field of health: An integrated review of the literature. Social Science & Medicine, 65, 782-791.

SCHOOL OF PHARMACY

Edited Book Mikov, M., & Fawcett, J. P. (Eds.). (2007). Bile acids: Chemistry, biosynthesis, analysis, chemical and metabolic transformations and pharmacology. Geneva, Switzerland: Mediset, 226p.

Journal – Research Article Balakrishnan, K., Tordoff, J., Norris, P., & Reith, D. (2007). Establishing a baseline for the monitoring of medicines availability for children in the UK: 1998-2002. British Journal of Clinical Pharmacology, 63(1), 85-91. Ball, D., Norris, P., Enlund, H., Tagwireyi, D., & Awad, A. (2007). Diversity amongst international pharmacy students. Pharmacy Education, 7(4), 379-386. Boyd, B. J., Rizwan, S. B., Dong, Y-D., Hook, S., & Rades, T. (2007). Self-assembled geometric liquid-crystalline nanoparticles imaged in three dimensions: Hexosomes are not necessarily flat hexagonal prisms. Langmuir, 23(25), 12461-12464. Braund, R., Tucker, I. G., & Medlicott, N. J. (2007). Hypromellose films for the delivery of growth factors for wound healing. Journal of Pharmacy and Pharmacology, 59(3), 367-372. Braund, R., Yuen, Y. C., & Jung, J. (2007). Identification and quantification of medication returned to Otago pharmacies. New Zealand Family Physician, 34, 258-262. Bulitta, J. B., Duffull, S. B., Kinzig-Schippers, M., Holzgrabe, U., Stephan, U., Drusano, G. L., & Sörgel, F. (2007). Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers. Antimicrobial Agents and Chemotherapy, 51(7), 2497-2507. Capstick, S., & Beresford, R. (2007). A comparison of student attitudes and intentions at the start and end of their BPharm degree programme. Pharmacy Education, 7(3), 267-277. Capstick, S., Green, J. A., & Beresford, R. (2007). Choosing a course of study and career in pharmacy: Student attitudes and intentions across three years at a New Zealand School of Pharmacy. Pharmacy Education, 7(4), 359-373. Chan, A., Isbister, G. K., Kirkpatrick, C. M. J., & Dufful, S. B. (2007). Drug-induced QT prolongation and torsades de pointes: Evaluation of a QT nomogram. QJM, 100, 609-615. Cvejic, J., Tambutté, S., Lotto, S., Mikov, M., Slacanin, I., & Allemand, D. (2007). Determination of canthaxanthin in the red coral (Corallium rubrum) from Marseille by HPLC combined with UV and MS detection. Marine Biology, 152(4), 855-862.

180 RESEARCH REPORT 2007/2008 Demana, P. H., Davies, N. M., Hook, S., & Rades, T. (2007). Analysis of Quil A-phospholipid mixtures using drift spectroscopy. International Journal of Pharmaceutics, 342, 49-61. Feltrin, K. L., Little, T. J., Meyer, J. H., Horowitz, M., Rades, T., Wishart, J., & Feinle-Bisset, C. (2007). Effects of lauric acid on upper gut motility, plasma cholecystokinin and peptide YY, and energy intake are load, but not concentration, dependent in humans. The Journal of Physiology, 581(2), 767-777. Gee, C. L., Drinkwater, N., Tyndall, J. D. A., Grunewald, G. L., Wu, Q., McLeish, M. J., & Martin, J. L. (2007). Enzyme adaptation to inhibitor binding: A cryptic binding site in phenylethanolamine N-methyltransferase. Journal of Medicinal Chemistry, 50(20), 4845-4853. Gordon, K. C., McGoverin, C. M., Strachan, C. J., & Rades, T. (2007). The use of quantum chemistry in pharmaceutical research as illustrated by case studies of indometacin and carbamazepine. Journal of Pharmacy and Pharmacology, 59, 271-277. Han, P. Y., Duffull, S. B., Kirkpatrick, C. M. J., & Green, B. (2007). Dosing in obesity: A simple solution to a big problem. Clinical Pharmacology and Therapeutics, 82(5), 505-508. Heinz, A., Savolainen, M., Rades, T., & Strachan, C. J. (2007). Quantifying ternary mixtures of different solid-state forms of indomethacin by Raman and near-infrared spectroscopy. European Journal of Pharmaceutical Sciences, 32, 182-192. Hennig, S., Waterhouse, T. H., Bell, S. C., France, M., Wainwright, C. E., Miller, H., Charles, B. G., & Duffull, S. B. (2007). A D-optimal designed population pharmacokinetic study of oral itraconazole in adult cystic fibrosis patients. British Journal of Clinical Pharmacology, 63(4), 438-450. Ho, L., Müller, R., Römer, M., Gordon, K. C., Heinämäki, J., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y. C., Strachan, C. J., Taday, P. F., & Zeitler, J. A. (2007). Analysis of sustained-release tablet film coats using terahertz pulsed imaging. Journal of Controlled Release, 119, 253-261. Isbister, G. K., Friberg, L. E., Hackett, L. P., & Duffull, S. B. (2007). Pharmacokinetics of quetiapine in overdose and the effect of activated charcoal. Clinical Pharmacology and Therapeutics, 81(6), 821-827. Isbister, G. K., Friberg, L. E., Stokes, B., Buckley, N. A., Lee, C., Gunja, N., Brown, S. G., MacDonald, E., Graudins, A., Holdgate, A., & Duffull, S. B. (2007). Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Annals of Emergency Medicine, 50(5), 593-600. Jiang, Y., Wang, J., Wang, Y., Du, X., Zhang, Y., Fawcett, J. P., & Gu, J. (2007). Determination of long-acting release octreotide, an octapeptide analogue of somatostation, in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 3982-3986. Jiang, Y., Wang, J., Wang, Y., Li, H., Fawcett, J. P., & Gu, J. (2007). Rapid and sensitive liquid chromatography-tandem mass spectrometry method for the quantitation of colchicine in human plasma. Journal of Chromatography B, 850, 564-568. Junyaprasert, V. B., Boonme, P., Songkro, S., Krauel, K., & Rades, T. (2007). Transdermal delivery of hydrophobic and hydrophilic local anesthetics from o/w and w/o Brij 97-based microemulsions. Journal of Pharmacy & Pharmaceutical Sciences, 10(3), 319-329. Kogermann, K., Zeitler, J. A., Rantanen, J., Rades, T., Taday, P. F., Pepper, M., Heinämäki, J., & Strachan, C. J. (2007). Investigating dehydration from compacts using terahertz pulsed, Raman, and near-infrared spectroscopy. Applied Spectroscopy, 61(12), 1265-1274. Krauel, K., Girvan, L., Hook, S., & Rades, T. (2007). Characterisation of colloidal drug delivery systems from the naked eye to Cryo-FESEM. Micron, 38, 796-803. Lee, C. J., Strachan, C. J., Manson, P. J., & Rades, T. (2007). Characterization of the bulk properties of pharmaceutical solids using nonlinear optics: A review. Journal of Pharmacy and Pharmacology, 59, 241-250. Lendemans, D. G., Egert, A. M., Hook, S., & Rades, T. (2007). Cage-like complexes formed by DOTAP, Quil-A and cholesterol. International Journal of Pharmaceutics, 332, 192-195. Li, X., Wang, Y., Wang, J., Fawcett, J. P., Zhao, L., & Gu, J. (2007). Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 247-251. Li, Y., Fawcett, J. P., Zhang, H., & Tucker, I. G. (2007). Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. Journal of Pharmacy and Pharmacology, 59, 503-511. Li, Y., Zhang, H., Fawcett, J. P., & Tucker, I. G. (2007). Quantitation and metabolism of mitoquinone, a mitochondria-targeted antioxidant, in rat by liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1958-1964. McGree, J. M., Duffull, S. B., Eccleston, J. A., & Ward, L. C. (2007). Optimal designs for studying bioimpedance. Physiological Measurement, 28, 1465-1483. Mikov, M., Boni, N. S., Al-Salami, H., Kuhajda, K., Kevresan, S., Golocorbin-Kon, S., & Fawcett, J. P. (2007). Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3α,7α-dihydroxy-12-oxo-5β-cholanate, in healthy and diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 32(1), 7-12. Mould, D. R., Denman, N. G., & Duffull, S. (2007). Using disease progression models as a tool to detect drug effect. Clinical Pharmacology & Therapeutics, 82(1), 81-86. Norris, P. (2007). Teaching pharmacy students about links between socio-economic status and health. Pharmacy Education, 7(2), 197-198. Norris, P., Dos Santos, R. B., Woods, D., & Tobata, W. (2007). Delivering medicines in a challenging environment: The pharmaceutical sector in East Timor (a descriptive study). Pharmacy Practice, 5(4), 145-150.

Division of HEALTH SCIENCES 181 Norris, P., & Nguyen, H. A. (2007). Consumption of antibiotics in a small Pacific island nation: Samoa. Pharmacy Practice, 5(1), 36-41. Parr, W. V., & Green, J. A. (2007). What is a typical Marlborough Savvy? New Zealand Winegrower, 10(6), 70. Parr, W. V., Green, J. A., White, K. G., & Sherlock, R. R. (2007). The distinctive flavour of New Zealand Sauvignon blanc: Sensory characterisation by wine professionals. Food Quality and Preference, 18, 849-861. Parr, W. V., Sherlock, R. R., & Green, J. A. (2007). The importance of green: Sensory and chemical analyses of New Zealand Sauvignon Blanc. Australian & New Zealand Grapegrower & Winemaker, (521a), 62-69. Patterson, J. E., James, M. B., Forster, A. H., Lancaster, R. W., Butler, J. M., & Rades, T. (2007). Preparation of glass solutions of three poorly water soluble drugs by spray drying, melt extrusion and ball milling. International Journal of Pharmaceutics, 336, 22-34. Pearl, E. J., Tyndall, J. D. A., Poulter, R. T. M., & Wilbanks, S. M. (2007). Sequence requirements for splicing by the Cne PRP8 intein. FEBS Letters, 581, 3000-3004. Popovic, M., Kolarovic, J., Mikov, M., Trivic, S., & Kaurinovic, B. (2007). Anthracycline-based combined chemotherapy in the mouse model. European Journal of Drug Metabolism and Pharmacokinetics, 32(2), 101-108. Poša, M., Kevrešan, S., Mikov, M., Cirin-Novta,´ V., & Kuhajda, K. (2007). Effect of cholic acid and its keto derivatives on the analgesic action of lidocaine and associated biochemical parameters in rats. European Journal of Drug Metabolism and Pharmacokinetics, 32(2), 109-117. Poša, M., Kevrešan, S., Mikov, M., Cirin-Novta,´ V., Sârbu, C., & Kuhajda, K. (2007). Determination of critical micellar concentrations of cholic acid and its keto derivatives. Colloids and Surfaces B: Biointerfaces, 59, 179-183. Rizwan, S. B., Dong, Y-D., Boyd, B. J., Rades, T., & Hook, S. (2007). Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryo FESEM). Micron, 38, 478-485. Savolainen, M., Heinz, A., Strachan, C., Gordon, K. C., Yliruusi, J., Rades, T., & Sandler, N. (2007). Screening for differences in the amorphous state of indomethacin using multivariate visualization. European Journal of Pharmaceutical Sciences, 30, 113-123. Siow, L. F., Rades, T., & Lim, M. H. (2007). Characterizing the freezing behavior of liposomes as a tool to understand the cryopreservation procedures. Cryobiology, 55, 210-221. Siow, L. F., Rades, T., & Lim, M. H. (2007). Effect of intra/extraliposomal distribution of sodium chloride on the stability of large unilamellar vesicles. CryoLetters, 28(6), 429-444. Strachan, C. J., Rades, T., & Gordon, K. C. (2007). A theoretical and spectroscopic study of γ-crystalline and amorphous indometacin. Journal of Pharmacy and Pharmacology, 59, 261-269. Strachan, C. J., Rades, T., Gordon, K. C., & Rantanen, J. (2007). Raman spectroscopy for quantitative analysis of pharmaceutical solids. Journal of Pharmacy and Pharmacology, 59, 179-192. Tantipolphan, R., Rades, T., McQuillan, A. J., & Medlicott, N. J. (2007). Adsorption of bovine serum albumin (BSA) onto lecithin studied by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy. International Journal of Pharmaceutics, 337, 40-47. Teng, G., Wang, Y., Tang, Y., Wang, R., Fang, Y., Fawcett, J. P., & Gu, J. (2007). Quantitation of iptakalim in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography B, 859, 256-260. Thomson, W. M., Poulton, R., Hancox, R. J., Ryan, K. M., & Al-Kubaisy, S. (2007). Changes in medication use from age 26 to 32 in a representative birth cohort. Internal Medicine Journal, 37, 543-549. Tian, F., Sandler, N., Aaltonen, J., Lang, C., Saville, D. J., Gordon, K. C., Strachan, C. J., Rantanen, J., & Rades, T. (2007). Influence of polymorphic form, morphology, and excipient interactions on the dissolution of carbamazepine compacts. Journal of Pharmaceutical Sciences, 96(3), 584-594. Tian, F., Saville, D. J., Gordon, K. C., Strachan, C. J., Zeitler, J. A., Sandler, N., & Rades, T. (2007). The influence of various excipients on the conversion kinetics of carbamazepine polymorphs in aqueous suspension. Journal of Pharmacy and Pharmacology, 59, 193-201. Tian, F., Zhang, F., Sandler, N., Gordon, K. C., McGoverin, C. M., Strachan, C. J., Saville, D. J., & Rades, T. (2007). Influence of sample characteristics on quantification of carbamazepine hydrate formation by X-ray powder diffraction and Raman spectroscopy. European Journal of Pharmaceutics and Biopharmaceutics, 66, 466-474. Wang, J., Jiang, Y., Wang, Y., Li, H., Fawcett, J. P., & Gu, J. (2007). Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high-performance liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry, 21, 1755-1758. Wang, Y., Wang, Y., Li, P., Tang, Y., Fawcett, J. P., & Gu, J. (2007). Quantitation of Armillarisin A in human plasma by liquid chromatography-electrospray tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 43, 1860-1863. Wen, J. Y., McLeod, B. J., Tucker, I. G., Davies, N. M., Ledger, R., & Butt, A. G. (2007). Enhancing absorption of fluorescein and LHRH across hindgut epithelia in a marsupial, the common brushtail possum Trichosurus Vulpecula. Journal of Pharmaceutical Sciences, 96(9), 2262-2273. Yeo, T. W., Lampah, D. A., Gitawati, R., Tjitra, E., Kenangalem, E., McNeil, Y. R., Darcy, C. J., Granger, D. L., Weinberg, J. B., Lopansri, B. K., Price, R. N., Duffull, S. B., Celermajer, D. S., & Anstey, N. M. (2007). Impaired nitric oxide bioavailability and L-arginine-reversible endothelial dysfunction in adults with falciparum malaria. Journal of Experimental Medicine, 204(11), 2693-2704.

182 RESEARCH REPORT 2007/2008 Zacharias, M., De Silva, R. K., Hickling, J., Medlicott, N. J., & Reith, D. M. (2007). Comparative safety and efficacy of two high dose regimens of oral paracetamol in healthy adults undergoing third molar surgery under local anaesthesia. Anaesthesia and Intensive Care, 35(4), 544-549. Zeitler, J. A., Kogermann, K., Rantanen, J., Rades, T., Taday, P. F., Pepper, M., Aaltonen, J., & Strachan, C. J. (2007). Drug hydrate systems and dehydration processes studied by terahertz pulsed spectroscopy. International Journal of Pharmaceutics, 334, 78-84. Zeitler, J. A., Shen, Y., Baker, C., Taday, P. F., Pepper, M., & Rades, T. (2007). Analysis of coating structures and interfaces in solid oral dosage forms by three dimensional terahertz pulsed imaging. Journal of Pharmaceutical Sciences, 96(2), 330-340. Zeitler, J. A., Taday, P. F., Gordon, K. C., Pepper, M., & Rades, T. (2007). Solid-state transition mechanism in carbamazepine polymorphs by time-resolved terahertz spectroscopy. ChemPhysChem, 8, 1924-1927. Zeitler, J. A., Taday, P. F., Newnham, D. A., Pepper, M., Gordon, K. C., & Rades, T. (2007). Terahertz pulsed spectroscopy and imaging in the pharmaceutical setting: A review. Journal of Pharmacy and Pharmacology, 59, 209-223. Zeitler, J. A., Taday, P. F., Pepper, M., & Rades, T. (2007). Relaxation and crystallization of amorphous carbamazepine studied by terahertz pulsed spectroscopy. Journal of Pharmaceutical Sciences, 96(10), 2703-2709.

Journal – Research Other Braund, R., & Abbott, J. H. (2007). Analgesic recommendations when treating musculoskeletal sprains and strains. The New Zealand Journal of Physiotherapy, 35(2), 54-60. Braund, R., Hook, S., & Medlicott, N. J. (2007). The role of topical growth factors in chronic wounds. Current Drug Delivery, 4, 195-204. McDowell, A., & McLeod, B. J. (2007). Physiology and pharmacology of the brushtail possum gastrointestinal tract: Relationship to the human gastrointestinal tract. Advanced Drug Delivery Reviews, 59, 1121-1132.

Journal – Professional & Other Non-Research Articles Al-Salami, H., Kansara, H., King, J., Morar, B., Jayathilaka, B., & Fawcett, P. (2007). Bile acids: A bitter sweet remedy for diabetes. New Zealand Pharmacy, (October), 17. Ho, L., Gordon, K. C., Rades, T., & Taday, P. (2007). Tune into terahertz: Terahertz pulsed-imaging could potentially advance tablet coating quality analysis. Pharmaceutical Formulation & Quality, (April-May), 48. Jones, D. S., & Rades, T. (2007). Themed issue: Applications of novel spectroscopic techniques to pharmaceutical systems. Journal of Pharmacy and Pharmacology, 59(2), 145-146. Lee, H. J., Fung, B., Lim, P., Tang, F., & Tominari, A. (2007). Role of gut microflora in drug metabolism: Pets or pests. New Zealand Pharmacy, (October), 21. McDowell, A., McLeod, B., Rades, T., & Tucker, I. (2007). Designing delivery systems for wildlife applications: The brushtail possum. Controlled Release Society Newsletter, 24(1), 13-15. Sandler, N., Savolainen, M., Saupe, A., Strachan, C., & Rades, T. (2007). Applications of Raman spectroscopy in aqueous environments. Pharmaceutical Technology Europe, 19(2). http://www.ptemag.com/pharmtecheurope/Analytical/ Applications-of-Raman-spectroscopy-in-aqueous-envi/ArticleStandard/Article/detail/408852 Tantipolphan, R., Rades, T., & Medlicott, N. J. (2007). Swellable lipid implants: Use of vibrational spectroscopy to study lipid and protein structure. Controlled Release Society Newsletter, 24(4), 14-16. Tyndall, J. D. A., & Duffull, S. B. (2007). New drugs targeting GPCRs: Recent agonists and antagonists in the clinic. Screening, 1, 22-25.

SCHOOL OF PHYSIOTHERAPY

Chapter in Book Baxter, G. D., & McDonough, S. M. (2007). Principles of electrotherapy in veterinary physiotherapy. In C. McGowan, L. Goff, & N. Stubbs (Eds.), Animal physiotherapy: Assessment, treatment and rehabilitation of animals (pp. 177-186). Ames, Iowa: Blackwell.

Journal – Research Article Ainslie, P. N., Murrell, C., Peebles, K., Swart, M., Skinner, M. A., Williams, M. J. A., & Taylor, R. D. (2007). Early morning

impairment in cerebral autoregulation and cerebrovascular CO2 reactivity in healthy humans: Relation to endothelial function. Experimental Physiology, 92(4), 769-777. Brandt, C., Sole, G., Krause, M. W., & Nel, M. (2007). An evidence-based review on the validity of the Kaltenborn rule as applied to the glenohumeral joint. Manual Therapy, 12, 3-11. Grieve, J., & Hale, L. (2007). Gait rehabilitation in acute transverse myelitis: A case report. The New Zealand Journal of Physiotherapy, 35(1), 17-23. Hadfield, I., Murdoch, G., Smithers, J., Vaioleti, L., & Patterson, H. (2007). Is a professional portfolio, as a record of continued professional development, the most effective method to assess a physiotherapist’s competence? The New Zealand Journal of Physiotherapy, 35(2), 72-83.

Division of HEALTH SCIENCES 183 Hale, L., Bray, A., & Littmann, A. (2007). Assessing the balance capabilities of people with profound intellectual disabilities who have experienced a fall. Journal of Intellectual Disability Research, 51(4), 260-268. Hale, L., Williams, K., Ashton, C., Connole, T., McDowell, H., & Taylor, C. (2007). Reliability of RT3 accelerometer for measuring mobility in people with multiple sclerosis: Pilot Study. Journal of Rehabilitation Research & Development, 44(4), 619-628. Harlick, J. C., Milosavljevic, S., & Milburn, P. D. (2007). Palpation identification of spinous processes in the lumbar spine. Manual Therapy, 12(1), 56-62. Hickey, B. W., Milosavljevic, S., Bell, M. L., & Milburn, P. D. (2007). Accuracy and reliability of observational motion analysis in identifying shoulder symptoms. Manual Therapy, 12, 263-270. Johnson, G. M., Coe, H., Wirawan, R., Wong, L., Lee, C., & MacFadyen, E. (2007). Objective discrimination between mandibular open/close excursion patterns: A clinical case report. The Journal of Craniomandibular Practice, 25(3), 218-224. Konstantinou, K., Foster, N., Rushton, A., Baxter, D., Wright, C., & Breen, A. (2007). Flexion mobilizations with movement techniques: The immediate effects on range of movement and pain in subjects with low back pain. Journal of Manipulative and Physiological Therapeutics, 30(3), 178-185. Liddle, S. D., Baxter, G. D., & Gracey, J. H. (2007). Chronic low back pain: Patients’ experiences, opinions and expectations for clinical management. Disability and Rehabilitation, 29(24), 1899-1909. Liddle, S. D., Gracey, J. H., & Baxter, G. D. (2007). Advice for the management of low back pain: A systematic review of randomised controlled trials. Manual Therapy, 12, 310-327. Milosavljevic, S., Carman, A. B., Schneiders, A. G., Milburn, P. D., & Wilson, B. D. (2007). Three-dimensional spinal motion and risk of low back injury during sheep shearing. Applied Ergonomics, 38(3), 299-306. Newsham-West, R., Nicholson, H., Walton, M., & Milburn, P. (2007). Long-term morphology of a healing bone-tendon interface: A histological observation in the sheep model. Journal of Anatomy, 210, 318-327. Pal, P., Milosavljevic, S., Sole, G., & Johnson, G. (2007). Hip and lumbar continuous motion characteristics during flexion and return in young healthy males. European Spine Journal, 16, 741-747. Smith, C., & Hale, L. (2007). The effects of non-pharmacological interventions on fatigue in four chronic illness conditions: A critical review. Physical Therapy Reviews, 12, 324-334. Smith, C., & Hale, L. (2007). The unique nature of fatigue in multiple sclerosis: Prevalence, pathophysiology, contributing factors and subjective experience. Physical Therapy Reviews, 12, 43-51. Sole, G., Hamrén, J., Milosavljevic, S., Nicholson, H., & Sullivan, S. J. (2007). Test-retest reliability of isokinetic knee extension and flexion. Archives of Physical Medicine and Rehabilitation, 88, 626-631. Takemura, M., Schneiders, A. G., Bell, M. L., & Milburn, P. D. (2007). Association of ground hardness with injuries in rugby union. British Journal of Sports Medicine, 41, 582-587. Tumilty, S. (2007). Achilles tendon rupture: Rising incidence in New Zealand follows international trends. Physical Therapy Reviews, 12, 59-65. Waters, D., & Hale, L. (2007). Do aqua-aerobics improve gait and balance in older people? A pilot study. International Journal of Therapy and Rehabilitation, 14(12), 538-542.

Journal – Research Other Abbott, J. H. (2007). Passive intervertebral motion tests for diagnosis of lumbar segmental instability. Australian Journal of Physiotherapy, 53, 66. Braund, R., & Abbott, J. H. (2007). Analgesic recommendations when treating musculoskeletal sprains and strains. The New Zealand Journal of Physiotherapy, 35(2), 54-60.

Journal – Professional & Other Non-Research Articles Abbott, J. H. (2007). International ‘cross-pollination’ in physiotherapy [Editorial]. The New Zealand Journal of Physiotherapy, 35(3), 97-98. Baxter, G. D. (2007). [Commentary on the article Immediate effects of acupuncture in chronic low back pain: So what’s new?]. Focus on Alternative and Complementary Therapies, 12(1), 40. Horton, S. J., & Franz, A. (2007). Mechanical diagnosis and therapy approach to assessment and treatment of derangement of the sacro-iliac joint. Manual Therapy, 12, 126-132. Paterson, S., Castinel, B., Newsham-West, R. J., & Milburn, P. D. (2007). Spinal canal encroachment demonstrated by a novel MRI technique of an axial loaded cervical spine: A case study. New Zealand Journal of Sports Medicine, 35(1), 23-25. Skinner, M. A. (2007). Physiotherapy education in New Zealand. Physical Therapy Reviews, 12(2), 122-128.

Journal – Other Abbott, H. J. (2007) “Letters to the Editor.” The Spine Journal, 7: 384-385 Abbott, H. J. (2007) “The validity of manual examination for assessing patients with neck pain.” New Zealand Journal of Physiotherapy, 35(2): 86.

184 RESEARCH REPORT 2007/2008 APPENDIX 2: PUBLICATIONS BY DEPARTMENT FOR 2008

FACULTY OF DENTISTRY DEPARTMENT OF ORAL DIAGNOSTIC AND SURGICAL SCIENCES

Journal – Research Article Ayers, K.M.S, Thomson, W.M, AL-Hassiny, H, Rich AM, Newton JT. A qualitative investigation of the experiences of immigrant dentists working in New Zealand. New Zealand Dental Journal; 104: 97-103, 2008. Ayers, K.M.S, Thomson, W.M, Whyman RA, Rich AM, Newton JT. (2008). Changes in the New Zealand dentist workforce over a nine-year period. New Zealand Dental Journal; 104: 19-26, 2008. Ayers, K.M.S, Thomson, W.M., Rich A.M., Newton, J.T. (2008). Gender differences in dentists’ working practices and job satisfaction. Journal of Dentistry; 36: 343-350. Ayers KMS, Thomson WM, Newton JT, Rich AM. (2008). Job stressors of New Zealand dentists and their coping strategies. Occupational Medicine 58: 275-281. Hobson R, S. Rolland, J. Rotgans, M. Schoonheim-Klein, H. Best, M. Chomyszyn-Gajewska, D. Dymock, R. Essop, J. Hupp, R. Kundzina, R. Love, R. A. Memon, M. Moola, L. Neumann, N. Ozden, K. Roth, P. Samwel, J. Villavicencio, P. Wright, and W. Harzer. (2008). Quality assurance, benchmarking, assessment and mutual international recognition of qualifications. European Journal of Dental Education 12: 92-100. Love R.M. and Y Ponnambalam. Dental and maxillofacial skeletal injuries seen at the University of Otago School of Dentistry 2000-2004. (2008). Dental Traumatology 24:170-176. Tong D.C., Theis J. (2008). Antibiotic prophylaxis and invasive dental treatment in prosthetic joint patients. New Zealand Medical Journal 121: 45-52. Tong D.C. (2008). The role of dentists in a mass casualty situation – a New Zealand perspective. Journal of Military and Veterans’ Health 16: 20-25. Tong D. C., Leaper M. R., Colquhoun A. N., Rich A. M. (2008). An unusual presentation of oropharyngeal mucosal plasmacytosis related to toothpaste. Journal of Laryngology and Otology. 122(10):1112-4.

FACULTY OF DENTISTRY DEPARTMENT OF ORAL REHABILITATION

Journal – Research Article Amanata N, He LH, Swain MV, Little DG. The effect of zoledronic acid on the intrinsic material properties of healing bone: an indentation study. Med Eng Phys. 2008 Sep;30(7):843-7. Barbagallo LJ, Shen G, Jones AS, Swain MV, Petocz P, Darendeliler MA. A novel pressure film approach for determining the force imparted by clear removable thermoplastic appliances. Ann Biomed Eng. 2008 Feb;36(2):335-41. Bennani V, Schwass D, Chandler N. (2008). Gingival retraction techniques for implant versus teeth: Current status. Journal of the American Dental Association 139(10): 1354-1363. Buchalla W, Imfeld T, Attin T, Swain MV, Schmidlin PR. Relationship between nanohardness and mineral content of artificial carious enamel lesions. Caries Res. 2008;42(3):157-63 Farah RA, Drummond BK, Swain MV, Williams S. Relationship between laser fluorescence and enamel hypomineralisation. J Dent. 2008 Nov;36(11):915-21. Field C, Li Q, Li W, Swain M. Influence of tooth removal on mandibular bone response to mastication. Arch Oral Biol. 2008 Dec;53(12):1129-37. Goga R, Chandler NP, Oginni AO. Pulp stones: a review. Int Endod J. 2008 Jun;41(6):457-68. Guidoni G, Swain M, Jueger I. Enamel: From brittle to ductile like tribological response. J Dent. 2008 Oct;36(10):786-94. Epub 2008 Jul 1. He LH, Standard OC, Huang TT, Latella BA, Swain MV. Mechanical behaviour of porous hydroxyapatite. Acta Biomater. 2008 May;4(3):577-86. He LH, Swain MV. Nanoindentation creep behavior of human enamel. J Biomed Mater Res A. 2008 Nov 3. [Epub ahead of print]. Kieser J, Singh B, Swain M, Ichim I, Waddell JN, Kennedy D, Foster K, Livingstone V. Measuring intraoral pressure: adaptation of a dental appliance allows measurement during function. Dysphagia. 2008 Sep;23(3):237-43. King S, See H, Thomas G, Swain M. Determining the complex modulus of alginate irreversible hydrocolloid dental material. Dent Mater. 2008 Nov;24(11):1545-8. Lim Y, Quick A, Swain M, Herbison P. Temperature effects on the forces, moments and moment to force ratio of nickel- titanium and TMA symmetrical T-loops. Angle Orthod. 2008 Nov;78(6):1035-42. Lin J, Chandler NP. Electric pulp testing: a review. Int Endod J. 2008 May;41(5):365-74. Rohanizadeh R, Swain MV, Mason RS. Gelatin sponges (Gelfoam) as a scaffold for osteoblasts. J Mater Sci Mater Med. 2008 Mar;19(3):1173-82.

Division of HEALTH SCIENCES 185 Roy R, Chandler NP, Lin J. Peripheral dentin thickness after root-end cavity preparation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Feb;105(2):263-6. Shibata Y, He LH, Toda Y, Kataoka Y, Fujisawa N, Miyazaki T, Swain MV. Micromechanical evaluation of mineralized multilayers. J Biomech. 2008 Dec 5;41(16):3414-8. Epub 2008 Nov 7. Shibata Y, He LH, Kataoka Y, Miyazaki T, Swain MV. Micromechanical property recovery of human carious dentin achieved with colloidal nano-beta-tricalcium phosphate. J Dent Res. 2008 Mar;87(3):233-7. Xie Z, Kilpatrick NM, Swain MV, Munroe PR, Hoffman M. Transmission electron microscope characterisation of molar- incisor-hypomineralisation. J Mater Sci Mater Med. 2008 Oct;19(10):3187-92. Xie Z, Swain M, Munroe P, Hoffman M. On the critical parameters that regulate the deformation behaviour of tooth enamel. Biomaterials. 2008 Jun;29(17):2697-703. Xue J, Li W, Swain MV. In vitro demineralization of human enamel natural and abraded surfaces: A micromechanical and SEM investigation. J Dent. 2009 Jan 7. Epub ahead of print. Yamamoto T, Ferracane JL, Sakaguchi RL, Swain MV. Calculation of contraction stresses in dental composites by analysis of crack propagation in the matrix surrounding a cavity. Dent Mater. 2008 Dec 17. Epub ahead of print. Zavgorodniy AV, Rohanizadeh R, Bulcock S, Swain MV. Ultrastructural observations and growth of occluding crystals in carious dentine. Acta Biomater. 2008 Sep;4(5):1427-39. Zavgorodniy AV, Rohanizadeh R, Swain MV. Ultrastructure of dentine carious lesions. Arch Oral Biol. 2008 Feb;53(2):124-32.

FACULTY OF DENTISTRY DEPARTMENT OF ORAL SCIENCES

Chapter in Book Seymour GJ, Cullinan MP. Susceptibility to periodontal disease:Host, bacteria and lifestyle. In: Shishubyogaku-No Shiten- Kara Mita Kokumin-No Kenkozoshin – Nihonshishubyogakkai 50 Shunen 1st edition, Eds; The Japanese Society of Periodontology, Ishiyaku Publishers, Inc Tokoyo Japan 2008 pp.3-12. Seymour GJ, Gemmell E, Yamazaki K. T cell responses in periodontitis. In: Periodontal Medicine and Systems Biology. Eds; Henderson B, Curtis M, Seymour RA, Donos N. Blackwell Publishing Limited, Oxford UK; 2008

Journal – Research Article Aarts J, Payne AGT, Thomson WM. (2008). Patients’ evaluation of two occlusal schemes for implant overdentures. Clinical Implant Dentistry and Related Research 10: 140-156. Antoun JS, Adsett LA, Goldsmith SM, Thomson WM. (2008). The oral health of older people: general dental practitioners’ beliefs and treatment experience. Special Care in Dentistry 28: 2-7. Ayers KMS, Thomson WM, Al-Hassiny H, Rich AM, Newton JT. (2008). A qualitative investigation of the experiences of immigrant dentists working in New Zealand. New Zealand Dental Journal 104: 97-103. Ayers KMS, Thomson WM, Newton JT, Rich AM. (2008).Job stressors of New Zealand dentists and their coping strategies. Occupational Medicine 58: 275-281. Ayers KMS, Newton JT, Thomson WM, Rich AM. (2008). Gender differences in dentists’ working practices and job satisfaction. Journal of Dentistry 36: 343-350. Ayers KMS, Thomson WM, Whyman RA, Rich AM, Newton JT. (2008). Changes in the New Zealand dentist workforce over a nine-year period. New Zealand Dental Journal 104: 19-26. Broadbent JM, Thomson WM, Poulton R. (2008). Trajectory patterns of dental caries experience to the fourth decade of life. Journal of Dental Research 87: 69-72. Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Seymour GJ, Middleton PG, Taylor JJ. Progression of periodontal disease and IL-10 gene polymorphism. Journal of Periodontal Research 2008; 43 : 328-333 Deng D, Lauren DR, Cooney JM, Jensen DJ, Wurms KV, Upritchard JE, Cannon RD, Wang MZ, Li MZ. Antifungal saponins from Paris polyphylla Smith. Planta Med. 2008 Sep;74(11):1397-402. Egan JG, Payne AGT, Thomson WM. (2008). Removable prosthodontic services, including implant-supported overdentures, provided by dentists and denturists. Journal of Oral Rehabilitation 35: 252-256. Forbes K, Thomson WM, Kunzel C, Lalla E, Lamster IB. (2008). Management of diabetic patients by general dentists in New Zealand. Journal of Periodontology 79: 1401-1408. Ford PJ, Seymour GJ, Beeley J, Curro F, DePaola D, Ferguson D, Finkelstein M, Gaengler P, Neo J, Niessen L, Oktay I, Park B-K, Woloskia A, Claffey N. Adapting to changes in molecular biosciences and technologies. Eur J Dent Educ 2008; 12 (Supp 1): 40-47. Hamlet SM, Ganashan N, Cullinan MP, Westerman B, Palmer JE, Seymour GJ. A 5-year longitudinal study of Tannerella forsythensis prtH genotype: association with loss of attachment. Journal of Periodontology 2008; 79:144-149. Holmes AR, Lin YH, Niimi K, Lamping E, Keniya M, Niimi M, Tanabe K, Monk BC, Cannon RD. ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates. Antimicrob Agents Chemother. 2008 Nov;52(11):3851-62.

186 RESEARCH REPORT 2007/2008 Kieser JA, Bernal V, Gonzalez P, Birch W, Turmaine M, Ichim I. (2008). Analysis of experimental cranial skin wounding from screwdriver trauma. International Journal of Legal Medicine 122:179-187. Kieser JA, Dall’Alba G, Livingstone V. (2008). Impact of curriculum on understanding of professional practice: a longitudinal study of students commencing dental education. Advances in Health Sciences Education (DOI 10.1007/s10459-008-9114-6). Kieser JA, DeFeiter J, TeMoananui R. (2008). Automated dental aging for child victims of disasters. American Journal of Disaster Medicine 3:109-112. Kieser JA, Livingstone V, Meldrum A. (2008). Professional storytelling in clinical dental anatomy teaching. Anatomical Sciences Education 1:84-89. Kieser JA, Singh B, Swain MV, Ichim I, Waddell JN, Kennedy D, Foster K. (2008). Measuring intra-oral pressure: adaptation of a dental appliance allows measurement during fnction. Dysphagia 23:237-243. Kieser JA, Whittle K, Wong B, Waddell JN, Ichim I, Swain M Taylor M, Nicholson H. (2008). Understanding craniofacioal blunt force injury: a biomechanical perspective. Forensic Pathology Reviews 5:39-51. Lamping E, Ranchod A, Nakamura K, Tyndall JD, Niimi K, Holmes AR, Niimi M, Cannon RD. Abc1p is a multidrug efflux transporter that tips the balance in favour of innate azole resistance in Candida krusei. Antimicrob Agents Chemother. 2008 Nov 17. Epub ahead of print. Lawrence HP, Thomson WM, Broadbent JM, Poulton R. (2008). Oral-health-related quality of life in a cohort of 32-year-olds. Community Dentistry and Oral Epidemiology 36: 305-316. Lawton BA, Rose SB, Kieser JA, Broadbent JM, Sussex PV, Thomson WM, Dowell AC. (2008). Disparities in edentulism and tooth loss between Mäori and non-Mäori New Zealand women. Australian and New Zealand Journal of Public Health 32: 254-260. Lim, Y, Quick A, Swain M, Herbison, P. (2008). Temperature Effects on the Forces, Moments and Moment to Force Ratio of Nickel-Titanium and TMA Symmetrical T-loops. Angle Orthodontist. 78(6): 1035-1042. Malden PE, Thomson WM, Jokovic A, Locker D. (2008). Changes in parent-assessed oral-health-related quality of life among young children following dental treatment under general anaesthetic. Community Dentistry and Oral Epidemiology 36: 108-117. Mladenovski A., JA Kieser. (2008). Efficacy of multimedia pre-operative information for patients: a pilot study. New Zealand Dental Journal 104:36-46. Monk BC, Goffeau A. Outwitting multidrug resistance to antifungals. Science. 2008 Jul 18;321(5887):367-9. Nash, D.R., Friedman, J.W., Kardos, T.B., Kardos, R.L., Schwarz, E., Satur, J., Berg, D.G., Nasruddin, J., Mumghamba, E.G., Davenport, E.S. and Nagel, R. (2008). Dental therapists: A global perspective. International Dental Journal 58:61-70. Odgers CL, Caspi A, Broadbent JM, Dickson N, Hancox RJ, Harrington HL, Poulton R, Sears MR, Thomson WM, Moffitt TE. (2008). Female and male antisocial trajectories: from childhood origins to adult outcomes. Development and Psychopathology 20: 673-716. Samotoi A, Moffat SM, Thomson WM. (2008). Musculoskeletal symptoms in New Zealand dental therapists: prevalence and associated disability. New Zealand Dental Journal 104: 49-53. Seymour GJ. The hygiene theory of acquired immunity and chronic periodontitis. J Periodontol 2008; 79(8):1314-6. Sosrenso W , Bird PS, Seymour GJ. Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide. J Periodontal Research 2008 Oct 22. Epub ahead of print. Sosroseno W, Musa M, Ravichandran M, Ibrahim MF, Bird PS, Seymour GJ. Effect of inhibition of inducible nitric oxide synthase (iNOS) on murine splenic immune response induced by Aggregatibacter (Actinobacillus) actinomycetemcomitans lipopolysaccharide. European Journal of Oral Sciences 2008; 116 (1): 31-36. Tay KI, Wu JM-Y, Yew MS-S, Thomson WM. (2008). The use of new technologies by New Zealand dentists. New Zealand Dental Journal 104: 104-108. TeMoananui R, Kieser JA, Herbison P, Liversidge H. (2008). Estimating age in Mäori, Pacific Island and European children from New Zealand. Journal of Forensic Sciences 53:401-404. TeMoananui R, Kieser JA, Herbison P, Liversidge H. (2008). Advanced dental maturation in New Zealand Mäori and Pacific Island children. American Journal of Human Biology 20:43-50 Thompson, K., Kardos, R. and Knapp, L. (2008). From Tourist to Treasure Hunter: A Self-Guided Orientation Programme for First Year Students. Health Information and Libraries Journal 25:69-73. Thomson WM, Poulton R, Broadbent JM, Moffitt TE, Caspi A, Beck JD, Welch D, Hancox RJ. (2008). Cannabis smoking and periodontal disease among young adults. Journal of the American Medical Association 299: 525-531. Whittle K, Kieser JA, Ichim I, Swain MV, Waddell JN, Livingstone V, Taylor M. (2008). The biomechanical modeling of non- ballistic skin wounding: blunt force injury. Forensic Science, Medicine and Pathology 4:33-39. Wong B, Kieser JA, Ichim I, Swain MV, Livingstone V, Waddell JN, Taylor M. (2008). Experimental simulation of non-ballistic wounding by sharp and blunt punches. Forensic Science Medicine Pathology (DOI 10.1007/s12024-008-9042-z)

Division of HEALTH SCIENCES 187 OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF ANATOMY AND STRUCTURAL BIOLOGY

Book – Edited Elford, R.J. and Jones, D.G. (eds) (2008) A Tangled Web Medicine and Theology in Dialogue, Peter Lang, Bern

Chapter in Book Buckley, H.R. and Whittle, K. (2008) Identifying child abuse in skeletonised subadult remains. 123-132 Jentzsch, I.M.V., Bagshaw, A., Buschiazzo, E., Merkel, A., Gemmell, N.J. (2008) Evolution of Microsatellite DNA. 1-12 Stringer, M.D (2008) Principles of Pediatric Surgery. In Bailey & Love’s Short Practice of Surgery N.S. Williams, C.J.K. Bulstrode and P.R. O’Connell. 71-89, Edward Arnold Publishers Ltd. Woodside, B., Augustine, R.A., Ladyman, S.R., Naef, L. and Grattan D.R. (2008) Role of prolactin in the metabolic adaptations to pregnancy and lactation. R.S. Bridges. 249-268, USA, Elsevier.

Journal – Research Article Abraham, W.C. and Williams, J.M. (2008) LTP maintenance and its protein synthesis-dependence. Neurobiology of Learning and Memory, 89, 260-268 Anderson, G.M., Kieser, D.C., Steyn, F.J. and Grattan, D.R. (2008) Hypothalamic prolactin receptor mRNA levels, prolactin signaling and hyperprolactinaemic inhibition of pulsatile LH secretion are dependent on estradiol. Endocrinology, 149, 4, 1562-70 Assinder, S.J., Stanton, J-A., and Prasad, P.D. (2008) Transgelin: An actin-binding protein and tumour suppressor. The International Journal of Biochemistry & Cell Biology, 41, 482-486 Attia, M.S., Stringer, M.D., McClean, P. and Prasad, K.R. (2008) The reduced left lateral segment in pediatric liver transplantation: An alternative to the monosegment graft. Pediatric Transplantation, 12, 696-700 Augustine, R.A. and Grattan, D.R. (2008) Induction of central leptin resistance in hyperphagic pseudopregnant rats by chronic prolactin infusion. Endocrinology, 149, 3, 1049-1055 Bagshaw, A.T.M., Pitt, J.P.W. and Gemmell, N.J. (2008) High frequency of microsatellites in S. cerevisiae meiotic recombination hotspots. BMC Genomics, 9, 49, 1-11 Brandstrom, M., Bagshaw, A.T., Gemmell, N.J. and Ellegren, H. (2008) The relationship between microsatellite polymorphism and recombination hot spots in the human genome. Molecular Biology and Evolution, 25, 12, 2579-2587 Buckley, H.R., Tayles, N.G., Spriggs, M.J.T. and Bedford, S. (2008) A preliminary report on health and disease in early Lapita Skeletons, Vanuatu: possible biological costs of island colonization. Journal of Island & Coastal Archaeology, 3, 87-114. Choi, A-R.A., Tamblyn, R. and Stringer, M.D. (2008) Electronic resources for surgical anatomy. Australian and New Zealand Journal of Surgery, 78, 1082-1091 Cornwall, J. and Stringer, M.D. (2008) Physical Injuries in the Dissecting Room. Clinical Anatomy, 21, 82-85 Dennison, K.J., Mahoney, P.M., Herbison, G.P. and Dias, G.J. (2008) The false bifid condyle. HOMO, The Journal of Comparative Human Biology, 59, 2, 149-159 Deries, M., Collins, J.J.P. and Duxson, M.J. (2008) The mammalian myotome: a muscle with no innervation. Evolution & Development, 10, 6, 746-755 Diykov, D., Barmashenko, G. and Hoffmann, K-P. (2008) Development of chloride homeostasis in albino and pigmented rat visual cortex neurons. Vision, Central, 19, 5, 595-598 Diykov, D., Turchinovich, A., Zoidl, G. and Hoffmann, K-P. (2008) Elevated intracellular chloride level in albino visual cortex neurons is mediated by Na-K-CI co-transporter. BMC Neuroscience, 9, 57 Douglas, S.A., Stevenson, K.E., Knowles, P.J. and Bunn, S.J. (2008) Characterization of catecholamine release from deer adrenal medullary chromaffin cells. Neuroscience Letters, 445, 126-129 Dowell, S.A., Boren, L.J., Negro, S.S., Muller, C.G., Caudon, A.K., Gemmell, N.J. (2008) Rearing two New Zealand fur seal (Arctocephalus forsteri) pups to weaning. Australian Journal of Zoology, 56, 33-39 Fleming, J. (2008) Who your gonna call? Communicating science in New Zealand. New Zealand Science Review, 64, 3-4, 75-76 Grattan, G.R. (2008) Fetal programming from maternal obesity: eating too much for two?. Endocrinology, 149, 11, 5345-5347 Halcrow, S., Tayles, N. and Livingstone, V. (2008) Infant death in late prehistoric Southeast Asia. Asian Perspectives, 47, 2, 371-404 Halcrow, S.E. and Tayles, N. (2008) Stress near the start of life? Localised enamel hypoplasia of the primary canine in late prehistoric mainland Southeast Asia. Journal of Archaeological Science, 35, 2215-2222 Halcrow, S.E. and Tayles, N. (2008) The bioarchaeological investigation of childhood and social age: problems and prospects. Journal of Archaeological Method and Theory, 15, 190-215 Han, H., Yao, Z., Wang, H., Deng, X., Fong, A.H.U. and Zhang, M. (2008) Dural entrance of the bridging vein into the transverse sinus provides a reliable measure for preoperative planning: an anatomic comparsion between cadavers and neuroimages. Neurosurgery, 62, 5 Suppl 2, 289-295 Harris, L.W., Wayland, M., Lan, M., Ryan, M., Giger, T., Lockstone, H., Wuethrich, I., Mimmack, M., Wang, L., Kotter, M., Craddock, R. and Bahn, S. (2008) The cerebral microvasculature in schizophrenia: a laser capture microdissection study. Plos one, 3, 12, 1-13 Herbison, A.E., Porteous, R., Pape, J-R., Mora, J.M. and Hurst, P.R. (2008) Gonadotropin-releasing hormone neuron requirements for puberty, ovulation, and fertility. Endocrinology, 149, 2, 597-604

188 RESEARCH REPORT 2007/2008 Hewitt, K.M. and Stringer M.D. (2008) Correlation between the surface area of synovial membrane and the surface area of articular cartilage in synovial joints of the mouse and human. Surgical and Radiological Anatomy, 30, 645-651 Hobbs, C., Murphy, M.P., Smith, R.A.J. and Oorschot, D.E. (2008) Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatrics International, 50, 481-488 Hobbs, C.E. and Oorschot, D.E. (2008) Neonatal rat hypoxia-ischemia: long-term rescue of striatal neurons and motor skills by combined antioxidant-hypothermia treatment. Brain Pathology, 18, 443-454 Horn, T., Gemmell, N.J., Robertson, B.C. and Bridges, C.R. (2008) Telomere length change in European sea bass (Dicentrarchus labrax). Australian Journal of Zoology, 56, 207-210 Humphrey, T.M. and Stringer, M.D. (2008) Diagnostic role of US for biliary atresia. Radiology, 247, 3, 912-913 Jones, D.G. (2008) Neuroethics: Adrift from a Clinical Base. The American Journal of Bioethics, 8, 1, 49-50 Jones, G. (2008) Embryonic stem cells: how dogmatic should Christians be?. Stimulus, 16, 2, 11-15 Jones, G.T. (2008) Animal models in chronic venous disease. Medicographia, 30, 2, 152-156 Jones, G.T., van Rij, A.M., Hill, G.B., Wilkins, G.T. and Williams, M.J.A. (2008) Common carotid intimal-medial thickness is associated with coronary in-stent restenosis. The Journal for Vascular Ultrasound, 32, 3, 129-132 Jones, G.T., Thompson, A.R., van Bockxmeer, F.M. Hafex, H., Cooper, J.A., Golledge, J. Humphries, S.E., Norman, P.E. and van Rij, A.M. (2008) Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler Thromb Vascular Biology, 28, 764-770 Kusakabe, M., Cheong, P-L., Nikfar, R., McLennan, I.S. and Koishi, K. (2008) The structure of the TGF-B latency associated peptide region determines the ability of the proprotien convertase furin to cleave TGF-B’s. Journal of Cellular Biochemistry, 103, 311-320 Larsen, C.M., Kokay, I.C. and Grattan, D.R. (2008) Male pheromones initiate prolactin-induced neurogenesis and advance maternal behaviour in female mice. Hormones and Behaviour, 53, 4, 509-17 Lee, M.W.L., McPhee, R.W. and Stringer, M.D. (2008) An evidence-based approach to human dermatomes. Clinical Anatomy, 21, 363-373 Leitch, B. and Pitman, R.M. (2008) Neuromodulation of Mechanosensory Input to the Insect CNS. Mechanosensitivity in Cells and Tissues, 2, 145-170 Li, C., Gao, X., Yang, F., Martin, S.K., Haines, S.R., Deng, X., Schofield, J. and Stanton, J-A. (2008) Development of a nude mouse model for the study of antlerogenesis – mechanism of tissue interactions and ossification pathway. Journal of Experimental Zoology, 310B, 1-18 Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C.L., Smith, P.F., Tucker, I.G. and Zhang, H. (2008) Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus, 18, 853-856 Liu, P., Collie, N.D., Chary, S., Jing, Y. and Zhang, H. (2008) Spatial learning results in elevated agmatine levels in the rat brian. Hippocampus, 18, 1094-1098 Liu, P., Gupta, N., Jing, Y. and Zhang, H. (2008) Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience, 155, 789-796 Liu, P., Rashaidhi, M., Collie, N.D., Leong, M-T. and Zhang, H. (2008) Behavioral effects of intracerebroventricular microinfusion of agmatine on adult rats. Behavioral Neuroscience, 122, 3, 557-569 Liu, P., Smith, P.F. and Darlington, C.L. (2008) Glutamate receptor subunits expression in memory-associated brain structures: regional variations and effects of aging. Synapse, 62, 834-841 McClea, K. (2008) The Bequest Programme at the University of Otago: cadavers donated for clinical anatomy teaching. The New Zealand Medical Journal, 121, 1274, 1-7 McGrath, C., Nicholson, H. and Hurst, P. (2008) The long posterior sacroiliac ligament: A histological study of morphological relations in the posterior sacroiliac region. Joint Bone Spine, 76, 57-62 Merkel, A. and Gemmell, N. (2008) Detecting short tandem repeats from genome data: opening the software black box. Briefings in Bioinformatics, 9, 5, 355-366 Merkel, A. and Gemmell, N.J. (2008) Detecting microsatellites in Genome Data: variance in definitions and bioinformatic approaches cause systematic bias. Evolutionary Bioinformatics, 4, 1-6 Needham, P., Dasgupta, D., Davies, J. and Stringer, M. (2008) Postoperative biochemical liver function after major hepatic resection in children. Journal of Pediatric Surgery, 43, 1610-1618 Oswald, M.J., Palmer, D.N., Kay, G.W., Barwell, K.J. and Cooper, J.D. (2008) Location and connectivity determine GABAergic interneuron survival in the brains of South Hampshire sheep with CLN6 neuronal ceroid lipofuscinosis. Neurobiology of Disease, 32, 50-65 Pascoe, K.C., Wlodek, M.E. and Jones, G.T. (2008) Increased elastic tissue defect formation in the growth restricted Brown Norway Rat: A potential link between In Utero Condition and Cardiovascular Disease. Pediatric Research, 64, 2, 125-130 Pietak, A.M., Mahoney, P.M., Dias, G.J. and Staiger, M.P. (2008) Bone-like matrix formation on magnesium and magnesium alloys. Journal of Materials Science: Materials in Medicine, 19, 1, 407-415 Robertson, B-A., Clements, K.M. and Wainwright, P.E. (2008) The working memory capabilities of the spontaneously hypertensive rat. Physiology and Behavior, 94, 481-486 Romano, N., Lee, K., Abraham, I.M., Jasoni, C.L. and Herbison, A.E. (2008) Nonclassical estrogen modulation of presynaptic GABA terminals modulates calcium dynamics in gonadotropin-releasing hormone neurons. Endocrinology, 149, 11, 5335-5344

Division of HEALTH SCIENCES 189 Rosengrave, P., Gemmell, N.J., Metcaolf, V., McBride, K. and Montgomerie, R. (2008) A mechanism for cryptic female choice in chinook salmon. Behavioral Ecology, 19, 6, 1179-1185 Shi, H., Cui, H., Alam, G., Gunning, W.T., Nestor, A., Giovannucci, D., Zhang, M. and Ding, H-F. (2008) Nestin expression defines both glial and neuronal progenitors in postnatal sympathetic ganglia. Journal of Comparative Neurology, 508, 867-878 Shindou, T., Arbuthnott, G.W. and Wickens, J.R. (2008) Actions of adenosine A2A receptors on synaptic connections of spiny projection neurons in the neostriatal inhibitory network. Journal of Neurophysiology, 99, 1884-1889 Slatter, T., Jones, G.T., Williams M.J.A, van Rij, A..M. and McCormick, S.P.A. (2008) Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics, 73, 179-184 Smart, C.E., Clarke, C., Brooks, K.M., Raghavendra, A., Brewster, B.L., French, J.D., Hetherington, R., Fleming, J.S., Rothnagel, J.A., Wainwright, B., Lakhani, S.R. and Brown, M.A. (2008) Targeted disruption of Brcal in restricted compartments of the mouse mammary epithelia. Breast Cancer Research and Treatment, 112, 237-241 Sole, G., Milosavljevic, S., Sullivan, S.J. and Nicholson, H. (2008) Running-related hamstring injuries: a neuromuscular approach. 13, 2, 102-110 Stahlschmidt, J., Stringer, M., Wyatt, J., Davison, S., Rajwal, S. and McClean, P. (2008) Histologic oddities at the porta hepatis in biliary atresia. Journal of Pediatric Surgery, 43, 1328-332 Steeves, T.E., Hale, M.L. and Gemmell, N.J. (2008) Development of polymorphic microsatellite markers for the New Zealand black stilt (Himantopus novaezelandiae) and cross-amplification in the pied stilt (Himantopus himantopus leucocephalus)., 8, 1105-1107 Steyn, F.J., Anderson, G.M. and Grattan, D.R. (2008) Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Endocrinology, 149, 6, 3206-3214 Stringer, M.D. (2008) Biliary atresia: service delivery and outcomes. Seminars in Pediatric Surgery, 17, 2, 116-122 Stringer, M.D. (2008) The clinical anatomy of congenital portosystemic venous shunts. Clinical Anatomy, 21, 147-157 Stringer, M.D. and Horward, L.J. (2008) Lack of association between tonsillectomy and subsequent appendicectomy. Journal of Pediatric Surgery, 43, 586-587 Stringer, M.D. and Nicholson, H.D. (2008) Modern models are already being applied. British Medical Journal, 337, 832 Tahir, N., Ramsden, W.H. and Stringer, M.D. (2008) Tracheobronchial anatomy and the distribution of inhaled foreign bodies in children. European Journal of Pediatrics, 168, 289-295 Thorirsson, T.E., Geller, F., Sulem, P., Rafnar, T., Wiste, A., Magnusson, K.P., Manolescu, A., Thorleifsson, G., Stefansson, H., Ingason, A., Stacey, S.N., Bergthorsson, J.T., Thorlacius, S., Gudmundsson, J., Jonsson, T., Jakobsdottir, M., Saemundsdottir, J., Olafsdottir, O., Gudmundsson, L., Bjornsdottir, K.K., Skuladottir, H., Isaksson, H.J., Gudbjartsson, T., Jones G.T. et al (2008) A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature, 452, 638-641 van Rij, A.M., Jones, G.T., Hill, G.B., Amer, M., Thomson, I.A., Pettigrew, I.A. and Packer S.G.K. (2008) Mechanical inhibition of angiogenesis at the saphenofemoral junction in the surgical treatment of varicose veins. Circulation, 118, 1, 66-74 Voros, J., Mitchell, A., Waldman, B., Goldstien, S. and Gemmell, N.J. (2008) Crossing the Tasman Sea: Inferring the introduction history of Litoria aurea and Litoria raniformis (Anura: Hylidae) from Australia into New Zealand. Austral Ecology, 33, 623-629 Warren, W.C., Hillier, L.W., Graves, J.A.M., Birney, E., Ponting, C.P., Grutzner, F., Belov, K., Miller, W., Clarke, L., Chinwalla, A.T., Yang, S-P., Heger, A., Locke, D.P., Miethke, P., Waters, P.D., Veyruns, F., Fulton, L., Fulton, B., Graves, T., Wallis, J., Puente, X.S., Lopez-Otin, C., Ordonez, G.R., Eichler, E.E., Chen, L., Cheng, Z., Deakin, J.E., Alsop, A., Thompson, K., Kirby, P., Papenfus, A.T., Wakefield, M.J., Olender, T., Lancet, D., Huttley, G.A., Smit, A.F., Pask, A., Temple-Smith, P., Batzer, M.A., Walker, J.A., Konkel, M.K., Harris, R.S., Whittington, C.M., Wong, E.S.W. and Gemmell, N.J. et al (2008) Genome analysis of the platypus reveals unique signatures of evolution. Nature, 453, 175-184 White, D.J., Wolff, J.N., Pierson, M. and Gemmell, N.J. (2008) Revealing the hidden complexities of mtDNA inheritance. Molecular Ecology, 17, 4925-4942 Wilson, M.T., Barry, M., Reynolds, J.N.J., Hutchison, E.J.W. and Steyn-Ross, D.A. (2008) Characteristics of temporal fluctuations in the hyperpolarized state of cortical slow oscillation. Physical Review, 77, 1-7 Wolff J.N. and Gemmell, N.J. (2008) Combining allele-specific fluorescent probes and restriction assay in real-time PCR to achieve SNP scoring beyond allele ratios of 1:1000. BioTechniques, 44, 2, 193-197 Wolff, J.N. and Gemmell, N.J. (2008) Lost in the zygote: the dilution of paternal mtDNA upon fertilization. Heredity, 101, 429-434 Wolff, J.N., Gandre, S., Kalinin, A. and Gemmell, N.J. (2008) Delimiting the frequency of paternal leakage of mitochondrial DNA in Chinook Salmon. Genetics, 179, 1029-1032 Woodley, S.J., Mercer, S.R. and Nicholson, H.D. (2008) Morphology of the bursae associated with the greater trochanter of the femur. Journal of Bone and Joint Surgery (Am), 90, 284-294 Woodley, S.J., Nicholson, H.D., Livingstone, V., Doyle, T.C., Meikle, G.R., Macintosh, J.E. and Mercer, S.R. (2008) Lateral hip pain: findings from magnetic resonance imaging and clinical examination. Journal of Orthopaedic & Sports Physical Therapy, 38, 6, 313-328 Woolley, A.G., Tait, K.J., Hurren, B.J., Fisher, L., Sheard, P.W. and Duxson, M.J. (2008) Developmental loss of NT-3 in-vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of schwann cells. GLIA, 56, 3, 306-317

190 RESEARCH REPORT 2007/2008 Wright, A.K., Miller, C., Williams, M. and Arbuthnott, G. (2008) Microglial activation is not prevented by tacrolimus but dopamine neuron damage is reduced in a rat model of Parkinson’s disease progression. Brain Research, 1216, 78-86 Yang, J.J., Larsen, C.M., Grattan, D.R. and Erskine M.S. (2008) Mating-induced neuroendocrine responses during pseudopregnancy in the female mouse. Journal of Neuroendocrinology, 21, 30-39.

Major Review Augustine, R.A., Ladyman, S.R. and Grattan, D.R. (2008) From feeding one to feeding many: hormone-induced changes in bodyweight homeostasis during pregnancy. Journal of Physiology, 586, 2, 387-397. Grattan, D.R. and Kokay, I.C. (2008) Prolactin: A pleiotropic neuroendocrine hormone. Journal of Neuroendocrinology, 20, 752-763. Grattan, D.R., Steyn, F.J., Kokay, I.C., Anderson, G.M. and Bunn, S.J. (2008) Pregnancy-induced adaptation in the neuroendocrine control of prolactin secretion. Journal of Neuroendocrinology, 20, 4, 497-507.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF BIOCHEMISTRY

Journal – Research Article Anjomshoaa, A., Lin, Y., Black, M., McCall, J., Humar, B., Song, S., Fukuzawa, R., Yoon, H., Holzmann, B., Friederichs, J., van Rij, A., Thompson-Fawcett, M. & Reeve, A. (2008). Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. British Journal of Cancer, 99, 966-973. Bentley, F.K., Luo, H., Dilbeck, P., Burnap, R.L. & Eaton-Rye, J.E. (2008). Effects of inactivating psbM and psbT on photodamage and assembly of photosystem II in Synechocystis sp. PCC 6803. Biochemistry, 47(44), 11637-46. Bernhardt, H., W Tate. Self-assembling transfer RNA has potential for nanoparticle arrays. Current Applied Physics (2008) vol. 8 (3-4) pp. 380-382. Bicknell, L.S., Pitt, J., Aftimos, S., Ramadas, R., Maw, M.A. & Robertson, S.P. (2008). A missense mutation in ALDH18A1, encoding Delta(1)-pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome. Eur J Hum Genet, vol. 16 (10), 1176-1186. Broom, J., D Hart, T Farr, W Nelson, K Neill, A Harvey, W Woelkerling. Utility of psbA and nSSU for phylogenetic reconstruction in the Corallinales based on New Zealand taxa. Molecular Phylogenetics and Evolution (2008) vol. 46 (3) pp. 958-973. Chen, C., Krause, K. & Pettitt, B. (2008). Advantage of Being a Dimer for Serratia marcescens Endonuclease. The Journal of Physical Chemistry B, 113(2), 511–521. Cox, A., J Pullar, G Hughes, E Ledgerwood, M Hampton. Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radical Biology and Medicine (2008) vol. 44 (6) pp. 1001-1009. Day, C., C Smits, F Fan, E Lee, W Fairlie, M Hinds. Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1. Journal of Molecular Biology (2008) vol. 380 (5) pp. 958-971. Day, R., Herridge, R., Ambrose, B. & Macknight, R. (2008). Transcriptome analysis of proliferating arabidopsis endosperm reveals biological implications for the control of syncytial division, cytokinin signalling, and gene expression regulation. Plant Physiol, 148, 1964-1984. Fukuzawa, R., M Anaka, R Heathcott, L McNoe, I Morison, E Perlman, A Reeve. Wilms tumour histology is determined by distinct types of precursor lesions and not epigenetic changes. J. Pathol. (2008) vol. 215 (4) pp. 377-387. Graziano, Annamaria Ruzzo, Francesco, Fotios Loupakis, et al. (including Bostjan Humar) Pharmacogenetic profiling for cetuximab plus irinotecan therapy in patients with refractory advanced colorectal cancer. J Clin Oncol (2008) vol. 26 (9) pp. 1427-1434. Hajibagheri K, Priesemann M, Morrison I, Parikh A, Lessof N, Price E. (2008). NICE guidance on urinary tract infection in children abandons routine antibiotic prophylaxis. Arch Dis Child. Arch Dis Child, 93(4):356. Heesch, S., Peters, A.F., Broom, J.E. & Hurd, C.L. (2008). Affiliation of the parasite Herpodiscus durvillaeae (Phaeophyceae) with the Sphacelariales based on DNA sequence comparisons and morphological observations. European Journal of Phycology, 43(3), 283-295. Hollis-Moffatt, J.E., Merriman, M.E., Rodger, R.A., Rowley, K.A., Chapman, P.T., Dalbeth, N., Gow, P.J., Harrison, A.A., Highton, J., Jones, P.B., O’Donnell, J.L., Stamp, L.K. & Merriman, T.R. (2008). Evidence for association of an interleukin-23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Ann Rheum Dis. 2008 Jul 22. doi: 10.1136/ ard.2008.090142 Holyoake, A., P O’sullivan, R Pollock, T Best, J Watanabe, Y Kajita, Y Matsui, M Ito, H Nishiyama, N Kerr, F Da Silva Tatley, L Cambridge, T Toro, O Ogawa, P Guilford. Development of a Multiplex RNA Urine Test for the Detection and Stratification of Transitional Cell Carcinoma of the Bladder. Clinical Cancer Research (2008) vol. 14 (3) pp. 742-749. Hong, Jiwon, Euphemia Leung, Alan G Fraser, Tony R Merriman, Prakash Vishnu, Geoffrey W Krissansen. IL4, IL10, IL16, and TNF polymorphisms in New Zealand Caucasian Crohn’s disease patients. Int J Colorectal Dis (2008) vol. 23 (3) pp. 335-337. Humar, B., P Guilford. Hereditary diffuse gastric cancer and lost cell polarity: A short path to cancer. Future Oncology (2008) vol. 4 (2) pp. 229-239.

Division of HEALTH SCIENCES 191 Jacobs, G., Chen, A., Stevens, S., Stockwell, P., Black, M., Tate, W. & Brown, C. (2008). Transterm: a database to aid the analysis of regulatory sequences in mRNAs. Nucleic Acids Research, 37 (Database issue), D72-D76. John, T., Black, M.A., Toro, T.T., Leader, D., Gedye, G.A., Davis, I.D., Guilford, P.J. & Cebon, J.S. (2008). Predicting clinical outcome through molecular profiling in stage III melanoma. Clinical Cancer Research, 14(16), 5173-5180. Kawanishi, H., Matsui, Y., Ito, M., Watanabe, J., Takahashi, T., Nishizawa, K., Nishiyama, H., Kamoto, T., Mikami, Y., Tanaka, Y., Jung, G., Akiyama, H., Nobumasa, H., Guilford, P., Reeve, A., Okuno, Y., Tsujimoto, G., Nakamura, E., Ogawa, O. (2008). Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer. Clin Cancer Res. 14(9):2579-87. Kleeberger, S.R., Martinez, F.D., Snieder, H., Kotb, M., Reeve, A., Uher, R., Braithwaite, A., Martin, N.G. & Rutter. M. (2008). Discussion. Novartis Foundation Symposium, 293, 192-197. Krueger, Christel, Ian M Morison. Random monoallelic expression: making a choice. Trends Genet (2008) vol. 24 (6) pp. 257-259. Kumble, K.D., Demmer, J., Fish, S., Hall, C., Corrales, S., DeAth, A., Elton, C., Prestidge,R., Luxmanan, S., Marshall, C.J. & Wharton, D.A. (2008). Characterization of a family of ice-active proteins from the Ryegrass, Lolium perenne. Cryobiology, 57(3), 263-268 Legge, M., Fitzgerald, R. & Jones, L. (2008). An alternative consideration in drug testing in elite athletes. NZ Med J, 121(1278), 73-7. Linke, K., P D Mace, C A Smith, D L Vaux, J Silke, C L Day. Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ (2008) vol. 15 (5) pp. 841-848. Luo, H. & Eaton-Rye, J. (2008). Directed mutagenesis of the transmembrane domain of the PsbL subunit of photosystem II in Synechocystis sp. PCC 6803. Photosynthesis Research, 98(1-3), 337-347. Mace, P.D., Linke, K., Feltham, R., Schumacher, F-R., Smith, C.A., Vaux, D.L., Silke, J. & Day, C.L. (2008). Structures of the cIAP2 RING Domain Reveal Conformational Changes Associated with Ubiquitin-conjugating Enzyme (E2) Recruitment. J Biol Chem, 283(46), 31633-40. Martin, N.G., Kleeberger, S.R., Braithwaite, A., Rutter, M., Kotb, M. & Reeve, A. (2008). Discussion. Novartis Foundation Symposium. 293, 178-180. Mckinney, C., Merriman, M.E., Chapman, P.T., Gow, P.J., Harrison, A.A., Highton, J., Jones, P.B.B., Mclean, L., O’Donnell, J.L., Pokorny, V., Spellerberg, M., Stamp, L.K., Willis, J., Steer, S. & Merriman, T.R. (2007). Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases, 67(3), 409-413. Mettrick, K.A., I. L Lamont. Iron signalling pathway interactions in the bacterium Pseudomonas aeruginosa. Febs J (2008) vol. 275 pp. 85-85. Morison, Ian M, Elisabeth M Cramer Bordé, Emma J Cheesman, et al. A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nat Genet (2008) vol. 40 (4) pp. 387-389. Murphy, A., K Woollard, A Hoang, N Mukhamedova, R Stirzaker, S McCormick, A Remaley, D Sviridov, J Chin-Dusting. High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response. Arterioscler Thromb Vasc Biol, 28(11), 2071-U313.. Nasri, Soroush, Helen More, Francesco Graziano, Annamaria Ruzzo, Emily Wilson, Anita Dunbier, Cushla Mckinney, Tony Merriman, Parry Guilford, Mauro Magnani, Bostjan Humar. A novel diffuse gastric cancer susceptibility variant in E-cadherin (CDH1) intron 2: A case control study in an Italian population. BMC Cancer (2008) vol. 8 (1) pp. 138. Nelson, W.A. & Broom, J.E.S. (2008). New Zealand Gigartinaceae (Rhodophyta): resurrecting Gigartina grandifida endemic to the Chatham Islands. New Zeal J Bot, 46(2), 177-187. Panjaworayan, Nattanan, Stephan K Roessner, Andrew E Firth, Chris M Brown. HBVRegDB: Annotation, comparison, detection and visualization of regulatory elements in hepatitis B virus sequences. Virol J (2007) vol. 4 (1) pp. 136. Payungporn, S., Chieochansin, T., Thongmee, C., Panjaworayan, N., Samransamruajkit, R., Theamboolers, A., Poovorawan, Y. (2008). Detection and discrimination of WU/KI polyomaviruses by real-time PCR with melting curve analysis. J Virol Methods, 153(1), 70-3. Pearl, E.J., Barker, D., Day, R.C. & Beck, C.W. (2008). Identification of genes associated with regenerative success of Xenopus laevis hindlimbs. Bmc Dev Biol, 8, 66. Phillips, Vicky K, Michael Legge, Lynnette M Jones. Maximal physiological responses between aquatic and land exercise in overweight women. Med Sci Sport Exer (2008) vol. 40 (5) pp. 959-964. Poulton, R., Martin, N.G., Uher, R., Rutter, M., Kleeberger, S.R., Dodge, K.A., Martinez, F.D., Kotb, M., Snieder, H., Reeve, A., Braithwaite, A. (2008). General discussion II. Novartis Foundation Symposium, 293, 122-127. Reid, David W, Gregory J Anderson, Iain L Lamont. Cystic fibrosis: ironing out the problem of infection? Am J Physiol-Lung C (2008) vol. 295 (1) pp. L23-L24. Reid, J.M., Morrison, I., Gorrie, G. & Metcalfe, R. (2008). Positive “ice-on-eyes” test in Miller Fisher syndrome. Pract Neurol., 8(3), 193-4. Roberts, R.L. J E Hollis-Moffatt, R B Gearry, M A Kennedy, M L Barclay, T R Merriman. Confirmation of association of IRGM and NCF4 with ileal Crohn’s disease in a population-based cohort. Genes and Immunity (2008) pp. 5. Ross, Meredith F, Tracy A Prime, Irina Abakumova, Andrew M James, Carolyn M Porteous, Robin A. J Smith, Michael P Murphy. Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem. J. (2008) vol. 411 (3) pp. 633. Sano, Makoto, Emiko Hayashi, Hitohiko Murakami, Hiroshi Kishimoto, Ryuji Fukuzawa, Norimichi Nemoto. Mcl-1, an anti- apoptotic Bcl-2 family member, essentially overlaps with insulin-producing cells in neonatal nesidioblastosis. Virchows Arch (2008) vol. 452 (4) pp. 469-470.

192 RESEARCH REPORT 2007/2008 Shaikly, V.R., Morrison, I.E., Taranissi, M., Noble, C.V., Withey, A.D., Cherry, R.J., Blois, S.M. & Fernández, N. (2008). Analysis of HLA-G in maternal plasma, follicular fluid, and preimplantation embryos reveal an asymmetric pattern of expression. J Immunol., 180(6), 4330-7 Shnyder, S., J Mangum, M Hubbard. Triplex Profiling of Functionally Distinct Chaperones (ERp29/PDI/BiP) Reveals Marked Heterogeneity of the Endoplasmic Reticulum Proteome in Cancer. J Proteome Res (2008). Slatter, T.L. G.T Jones, M.J Williams, A.M van Rij, S.P McCormick. Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clin Genet (2008) vol. 73 (2) pp. 179-184. Smith, T., D. A Wharton, C. J Marshall. Cold tolerance of an Antarctic nematode that survives intracellular freezing: comparisons with other nematode species. J Comp Physiol B (2008) vol. 178 (1) pp. 93-100. Smits, Callum, Peter E Czabotar, Mark G Hinds, Catherine L Day. Structural plasticity underpins promiscuous binding of the prosurvival protein a1. Structure (2008) vol. 16 (5) pp. 818-829. Spencer, Matthew R, Paul A Beare, Iain L Lamont. Role of cell surface signaling in proteolysis of an alternative sigma factor in Pseudomonas aeruginosa. J Bacteriol (2008) vol. 190 (14) pp. 4865-9. Taylor, C., D Ireland, I Ballagh, K Bourne, N Marechal, P Turner, D Bilkey, W Tate, W Abraham. Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiology of Disease (2008) vol. 31 (2) pp. 250-260. Ting, R., Harwig, C., auf dem Keller, U., McCormick, S., Austin, P., Overall, C.M., Adam, M.J., Ruth, T.J. Perrin, D.M. (2008). Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice. J Am Chem Soc., 10;130(36), 12045-55. Uher, R., Dodge, K.A., Martinez, F.D., Reeve, A., Martin, N.G., Braithwaite, A., Rutter, M., Snieder, H., Battaglia, M., Tesson, F. & Kotb. M. (2008). Discussion. Novartis Foundation Symposium, 293, 97-102. Upritchard, H.G., Cordwell, S.J. & Lamont, I.L. (2008). Immunoproteomics to examine cystic fibrosis host interactions with extracellular Pseudomonas aeruginosa proteins. Infect Immun, 76(10), 4624-4632. Wehmeyer, M.L., Buntinx, W.H., Lachapelle, Y., Luckasson, R.A., Schalock, R.L., Verdugo, M.A., Borthwick-Duffy, S., Bradley, V., Craig, E.M., Coulter, D.L., Gomez, S.C., Reeve, A., Shogren, K.A., Snell, M.E., Spreat, S., Tassé, M.J., Thompson, J.R. & Yeager, M.H. (2008). The intellectual disability construct and its relation to human functioning. Intellect Dev Disabil., 46(4),311-8. Willis, Amanda L, Nhan L Tran, Julie M Chatigny, Nichole Charlton, Hong Vu, Sharron A. N Brown, Michael A Black, Wendy S McDonough, Shannon P Fortin, Joshua R Niska, Jeffrey A Winkles, Heather E Cunliffe. The fibroblast growth factor- inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity. Mol Cancer Res (2008) vol. 6 (5) pp. 725-734. Wilson, M.J, P.K Dearden. Evolution of the insect Sox genes. BMC Evol Biol (2008) vol. 8 (1) pp. 120. Winnard, D. T Kake, P Gow, C Barratt-Boyes, V Harris, D.-A Hall, H Mason, T Merriman, N Dalbeth. Debunking the myths to provide 21st Century management of gout. New Zealand Medical Journal (2008) vol. 121 (1274) pp. 79-85. Young, J.M., J. L Juengel, K. G Dodds, M Laird, P. K Dearden, A. S Mcneilly, K. P Mcnatty, T Wilson. The activin receptor-like kinase 6 Booroola mutation enhances suppressive effects of bone morphogenetic protein 2 (BMP2), BMP4, BMP6 and growth and differentiation factor-9 on FSH release from ovine primary pituitary cell cultures. Journal of Endocrinology (2008) vol. 196 (2) pp. 251-261.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY

Chapter in Book – Research Tagg, J.R., Burton, J.P. Wescombe, P.A., & Chilcott, C.N. 2008. Streptococci as effector organisms for probiotic and replacement therapy. In: Therapeutic Microbiology: Probiotics and Related Strategies. Versalovic, J. & Wilson, M. (Eds) ASM Press, Washington DC.

Journal – Research Article Alqumber, M.A., Burton, J.P., Devenish, C., & Tagg, J.R. 2008. A species-specific PCR for Lactobacillus iners demonstrates a relative specificity for this species for vaginal colonization. Microbial Ecology in Health and Disease, 20: 135-139. Cebe-Suarez, S., Grunewald, F. S., Jaussi, R., Li, X., Glaesson-Welsh, L., Spillmann, D., Mercer, A.A., Prota, A.E. and Ballmer- Hofer, K. 2008. Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. The FASEB Journal, Research Communication, 22:3078-3086. Cosseau, C., Devine, D.A., Dullaghan, E., Gardy, J.L., Chitatamarla, A., Gellatly, S., Yu, L.L., Pistolic, J., Falsafi, R., Tagg, J., & Hancock, R.E.W. 2008. The commensal Streptococcus salivarius K12 downregulates the innate immune response of human epithelial cells and promotes host-microbe homeostasis. Infection and Immunity, 76(9), 4163-4175. Fairley, R.A., Whelan, E.M., Pesavento, P.A. and Mercer, A.A. 2008. Recurrent localized cutaneous parapoxvirus infection in three cats. New Zealand Veterinary Journal, 56(4), 196-201. Gatehouse, L.N., Markwick, N.P., Poulton, J., Young, V.L., Ward, V.K. and Christeller, J.T. 2008. Expression of two heterologous proteins depends on the mode of expression: comparison of in vivo and in vitro methods. Bioprocess Biosyst. Eng. 31:469-475.

Division of HEALTH SCIENCES 193 Gauntlett, J.G., Gebhard, S., Keis, S., Manson, J.M., Pos K.M. and Cook, G.M. 2008. Molecular analsysis of BcrR, a membrane- bound bacitracin sensor and DNA-binding protein from enterocuccus faecalis. The Journal of Biological Chemistry, 283(13) 8591-8600. Gebhard, S., Humpel, A., McLellan, A.D. and Cook, G.M. 2008. The alternative sigma factor SigF of Mycobacterium smegmatis is required for survival of heat shock, acidic pH and oxidate stress. Microbiology, 154:2786-2795. Gebhard, S. and Cook, G.M. 2008. Differential Regulation of High-Affinity Phosphate Transport Systems of Mycobacterium smegmatis: Identification of PhnF, a Repressor of the phnDCE Operon. Journal of Bacteriology, 190(4): 1335-1343. Gristwood T., Fineran, P.C., Everson, L. and Salmond, G.P.C. 2008. PigZ, a TetR/AcrR family repressor, modulates secondary metabolism via the expression of a putative four-component resistance-nodulation-cell-division efflux pump, ZrpADBC, in Serratia sp. ATCC 39006. Molecular Microbiology 69(2), 418-435. Hartschuh, R.D., Wargacki, S.P., Xiong, H., Neiswinger, J., Kisliuk, A., Sihn, S., Ward, V., Vaia, R.A. and Sokolov, A.P. 2008. How rigid are viruses. Physical Review E Stan Nonlin Soft Matter Phys, 78 (2 part 1): epub 15 Aug. Inder, M.K., Wise, L.M., Fleming, S.B. and Mercer, A.A. 2008. The C-terminus of viral vascular endothelial growth factor-E partically blocks binding to VEGF receptor-1. FEBS Journal 275:207-217. Jones, R.J., Hussein, H.M., Zagorec, M., Brightwell, G. and Tagg, J.R. 2008. Isolation of lactic acid bacteria with inhibitory activity against pathogens and spoilage organisms associated with fresh meat. Food Microbiology 25:228-234. McQueen, R.H., Laing, R.M., Delahunty, C.M., Brooks, H.J.L. and Niven, B.E. 2008. Retention of axillary odour on apparel fabrics. TJTI, p.1-9. Peacey, M., Wilson, S., Perret, R., Ronchese, F., Ward, V.K., Young, V., Young, S.L. and Baird, M. A. 2008. Virus-like particles from rabbit hemorrhagic disease virus can induce an anti-tumour response. Vaccine, 26(42):5334-7. Power, D.A., Burton, J.P., Chilcott, C.N., Dawes, P.J. and Tagg, J.R. 2008. Preliminary investigations of the colonization of upper respiratory tract tissues of infants using a paediatric formulation of the oral probiotic Streptococcus salivarius K12. Eur J Clin Microbiol Infect Dis. Jun 17, epub. Robinson, M., O’Brien, R., Mackintosh, C. and Griffin, F. 2008. Differential immune responses of Red Deer (Cervus elaphus) following experimental challenge with Mycobacterium avium subsp. paratuberculosis. Clinical and Vaccine Immunology, 15(6), 963-969. Saunderson, S. C., Schuberth, P.C., Dunn, A.C., Miller, L., Hock, B.D., MacKay, P.A., Koch, N., Jack, R.W. and McLellan, A.D. 2008. Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor. The Journal of Immunology, 180:8146-8152. Sonnberg, S., Seet, B.T., Pawson, T., Fleming, S.B. and Mercer, A.A. 2008. Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes. PNAS, 105(31), 10955-10960. Vijaysri, S., Jentarra, G., Heck, M.C., Mercer, A.A., McInnes, C.J. and Jacobs, B.L. 2008. Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Intra-nasal vaccination. Vaccine, 26:664-676. Von Ballmoos, C., Cook, G.M. and Dimroth, P. 2008. Unique Rotary ATP Synthase and Its Biological Diversity. Annu. Rev. Biophys. 37:43-64. Williamson, N.R., Fineran, P.C., Ogawa, W., Woodley L.R. and Salmond, G.P.C. 2008. Integrated regulation involving quorum sensing, a two-component system, a GGDEF/EAL domain protein and a post-transcriptional regulator controls swarming and RhIA-dependent surfactant biosynthesis in Serratia. Environmental Microbiology 10(5), 1202-1217. Williman, J., Young, S., Buchan, G., Slobbe, L., Wilson, M., Pang, P., Austyn., J., Preston, S. and Baird, M. 2008. DNA fushion vaccines incorporating IL-23 or RANTES for use in immunization against influenza. Vaccine 26(40):5153-8. Wilson, S., Baird, M. and Ward, V.K. 2008. Delivery of vaccine peptides by rapid conjugation to baculovirus particles. Vaccine, 26:2451-2456.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF PHARMACOLOGY AND TOXICOLOGY

Book Ashton JC, Glass M. Brain Hypoxia-Ischemia Research Progress. (2008). Nova Publishers ISBN 978-1-60456-139-5.

Journal – Research Article Ashton JC, Milligan ED. Cannabinoids for the treatment of neuropathic pain: Clinical evidence. Current Opinion in Investigational Drugs. (2008). 9: 1, 65-75. Ashton JC, Smith PF, Darlington CL. (2008). The effect of Delta(9)-tetrahydrocannabinol on the extinction of an adverse associative memory. Pharmacology 81: 18-20. Ashton JC, Wright JL, McPartland JM, Tyndall JDA. (2008). Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agents. Current Medical Chemistry, 15, 1428-1443. Darlington CL. (2008). The changing face of insulin receptors. Current Opinion in Investigational Drugs. 8: 885-886 . Goddard M, Zheng Y, Darlington CL, Smith PF. Locomotor and exploratory behavior in the rat following bilateral vestibular deafferentation. Behavioral Neuroscience (2008). vol 122 No 2: 448-459. Goddard M, Zheng Y, Darlington CL, Smith PF. Synaptic protein expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Hippocampus (2008). 18:440-444.

194 RESEARCH REPORT 2007/2008 Goddard M, Zheng Y, Darlington CL, Smith PF. Effects of bilateral vestibular deafferentation on anxiety related behaviours in wistar rats. Behavioral Brain Research 193 (2008) 55-62. Goddard M, Zheng Y, Darlington CL, Smith PF. (2008). Monomine transporter and enzyme expression in the medial temporal lobe and frontal cortex following chronic bilateral vestibular loss. Neuroscience Letters 437: 107-110. Liu P, Chary S, Devaraj R, Jing Y, Darlington CL, Smith PF, Tucker IG, Zhang H. (2008). Effects of aging on agmatine level in memory-associated brain structures. Hippocampus 18:853-856. Liu P, Smith PF, Darlington CL. (2008). Glutamate receptor subunit expression in memory-associated brain structures: regional variations and effects of aging. Synapse 62:834-841. Mihoko N, Fawcett JP, Rosengren R. (2008). Induction of in vitro EROD activity an in vivo caffeine metabolism in two species of New Zealand birds. Environmental Toxicology and Pharmacology 25: 358-364. Pugazhenthi K, Kapoor M, Clarkson AN, Hall I, Appleton IA (2008). Melatonin accelerates the process of wound repair in full-thickness incisional wounds. J Pineal Res. Jan 19 epub. Scandlyn MJ, Stuart EC, Rosengren R. (2008). Sex-specific differences in CYP450 isoforms in humans. Expert Opinion on Drug Metabolism & Toxicology, 4 No. 4, 413-424. Somers-Edgar TJ, Scandlyn MJ, Stuart EC, Le Nedelec MJ, Valentine SP, Rosengren R. (2008). The combination of epigallocatechin gallate and curcumin supresses ERa-breast cancer cell growth in vitro and in vivo. International Journal of Cancer 122, 1966-1971. Stuart EC, Rosengren R (2008). The combination of raloxifene and epigallocatechin gallate suppresses growth and induces apoptosis in MDA-MB-231 cells. Life Sciences 82: 943 – 948. Vranyac-Tramoundanas A, Harrison JC, Clarkson AN, Kapoor M, Winburn IC, Kerr S, Sammut I. (2008). Toxicological Sciences 105(2), 395-407. Zheng Y, Hooton K, Smith PF, Darlington CL. Carbamazepine reduces the behavioural manifestations of tinnitus following salicylate treatment in rats. Acta Oto-Larygological, 2008, 128: 48-52.

OTAGO SCHOOL OF MEDICAL SCIENCES DEPARTMENT OF PHYSIOLOGY

Chapter in Book Adams, S.L., Hessian, P.A., & Mladenov, P.V. (2008) Cryopreservation of sea urchin (Evechinus chloroticus) sperm. In: Methods in Reproductive Aquaculture, Marine and Freshwater Species. (Eds) E. Cabrita, V. Robles & P. Herráez. CRC Press, Boca Raton, Florida, pp. 501-504. Arbuthnott, G., Dejean, C., & Hyland, B. (2008) Antidromic cortical activity as the source of therapeutic actions of deep brain stimulation. In: Cortico-subcortical dynamics in Parkinson’s disease. (Ed) Tseng, K.Y. Humana Press. Cohen, R., Schmitt, B.M., & Atlas, D. (2008) Reconstitution of depolarization and Ca2+-evoked secretion in Xenopus oocytes monitored by membrane capacitance. In: Methods in Molecular Biology, Vol. 440, Exocytosis and Endocytosis. (Ed) A. Ivanov, Humana Press, Inc., Totowa, NJ, pp 261-275. Heinbockel, T., & Heyward, P.M. (2008) Glutamate synapses in olfactory neural circuits. In: Amino Acid Receptor Research. Benjamin F. Paley and Tomas E. Warfield (Eds). Nova Science Publishers.

Journal – Research Article Ainslie, P.N. (2008) Sympathetic activity does influence cerebral blood flow: Point-counterpoint debate. Journal of Applied Physiology, 105: 1370-1371. Ainslie, P.N., & Burgess, K.R. (2008) Cardiorespiratory and cerebrovascular responses to hyperoxic and hypoxic rebreathing; effects of acclimatization to high altitude. Respiratory Physiology and Neurobiology, 161: 201-209. Ainslie, P.N., Cotter, J.D., George, K.P., Lucas, S., Murrell, C., Shave, R., Thomas, K.N., Williams, M.J.A., & Atkinson, G. (2008) Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. Journal of Physiology, 586(16): 4005-4010. Ainslie, P.N., Hamlin, M., Hellemans, J., Rasmussen, P., & Ogoh, S. (2008) Cerebral hypoperfusion during hypoxic exercise following two hypoxic exposures: independence from changes in dynamic autoregulation and reactivity. American Journal of Physiology, 295(5): R1613-R1622. Ainslie, P.N., Ogoh, S., Burgess, K., Celi, L., McGrattan, K., Peebles, K., Murrell, C., Subedi, P., & Burgess, K.R. (2008) Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia. Journal of Applied Physiology, 104: 490-498. Ainslie, P.N., Celi, L., McGrattan, K., Peebles, K., & Ogoh, S. (2008). Dynamic cerebral autoregulation and baroreflex sensitivity

during modest and severe step changes in arterial PCO2. Brain Research, 1230: 115-124. Al-Salami, H., Butt, G., Fawcett, J.P., Tucker, I.G., Golocorbin-Kon, S., & Mikov, M. (2008). Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics, 33(2): 101-106. Al-Salami, H., Butt, G., Tucker, I., Skrbic, R., Golocorbin-Kon, S., & Mikov, M. (2008) Probiotic treatment proceeded by a single dose of bile acid and gliclazide exert the most hypoglycemic effect in a rat model of type 1 diabetic rats. Medical Hypothesis and Research Journal, 4(2): 93-101.

Division of HEALTH SCIENCES 195 Al-Salami, H., Butt, G., Tucker, I., & Mikov, M. (2008). Influence of the semisynthetic bile acid (MKC) on the ileal permeation of gliclazide in healthy and diabetic rats. Pharmacological Reports, 60(4): 532-541. Al-Salami, H., Butt, G., Tucker, I., Skrbic, R., Golocorbin-Kon, S., & Mikov, M. (2008)Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rats to the level seen in untreated healthy rats. Archives of Drug Information, 1: 35-41. Al-Salami, H., Butt, G., Tucker, I., & Mikov, M. (2008). Influence of the semisynthetic bile acid MKC on the ileal permeation of gliclazide in vitro in healthy and diabetic rats treated with probiotics. Methods and Findings in Experimental and Clinical Pharmacology, 30: 1-7. Anglem, N., Lucas, S.J.E., Rose, E.A., & Cotter, J.D. (2008). Mood, illness and injury responses and recovery with Adventure Racing. Wilderness and Environmental Medicine, 19(1): 30-38 Aravamuthan, B.R., Bergstrom, D.A., French, R.A., Taylor, J.J., Parr-Brownlie, L.C., & Walters, J.R. (2008) Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson’s disease. Experimental Neurology, 213(2): 268-280. Bailey, D.M., Evans, K.A., James, P.E., McEneny, J., Young, I.S., Fall, L., Gutowski, M., Kewley, E., McCord, J.M., Moller, K., & Ainslie, P.N. (2008). Altered free radical metabolism in acute mountain sickness: implications for dynamic cerebral autoregulation and blood-brain barrier function. Journal of Physiology, 2008 Oct 20. Epub ahead of print. Bartolo, R.C., & Donald, J.A. (2008) The effect of water deprivation on the tonicity responsive enhancer binding protein (TonEBP) and TonEBP-regulated genes in the kidney of the Spinifex hopping mouse, Notomys alexis. Journal of Experimental Biology, 211(Pt 6): 852-859. Bedford, J.J., Weggery, S., Ellis, G., McDonald, F.J., Joyce, P.R., Leader, J.P., & Walker, R.J. (2008) Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride. Clinical Journal of the American Society of Nephrology, 3(5): 1324-1331. Bolter, C.P., & English, D.J. (2008) The effects of tertiapin-Q on responses of the sinoatrial pacemaker of the guinea-pig heart to vagal nerve stimulation and muscarinic agonists. Experimental Physiology, 93: 53-63. Brown, C.H., Brunton, P.J., & Russell, J.A. (2008) Rapid estradiol-17β modulation of opioid actions on the electrical and secretory activity of rat oxytocin neurons in vivo. Neurochemical Research, 33: 614-623. Brown, C.H., Ruan, M., Scott, V., Tobin, V.A., & Ludwig, M. (2008) Multi-factorial somato-dendritic regulation of phasic spike discharge in vasopressin neurons. Progress in Brain Research, 170: 219-228. Burgess, K., Burgess, K., Subedi, P., Ainslie, P.N., Topor, Z., & Whitelaw, W. (2008) Prediction of periodic breathing at altitude. Advances in Experimental Medicine and Biology, 605: 442-446. Chen, H-Y., Wu, J-S., Hyland, B.I., Lu, X-D., & Chen, J-J.J. (2008) A low noise remotely controllable wireless telemetry system for single-unit recording in rats navigating in a vertical maze. Medical and Biological Engineering and Computing, 46: 833-839. Clarkson, J., d’Anglemont de Tassigny, X., Moreno, A.S., Colledge, W.H., & Herbison, A.E. (2008) Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge. Journal of Neuroscience 28: 8691-8697. Constantin, S., & Wray, S. (2008) Gonadotropin-releasing hormone-1 neuronal activity is independent of cyclic nucleotide- gated channels. Endocrinology, 149: 279-290. Constantin, S., & Wray, S. (2008) GnRH-1 neuronal activity is independent of HCN channels but is sensitive to PKA- dependent phosphorylation. Endocrinology, 149(7): 3500-3511. Dejean, C., Hyland, B., & Arbuthnott, G. (2008) Cortical effects of subthalamic stimulation correlate with behavioral recovery from dopamine antagonist induced akinesia. Cerebral Cortex, 2008 Sep 11. Epub ahead of print. Eller, L., Ainslie, P.N., Poulin, M.J., & Reimer, R. (2008) Differential responses of circulating amylin to high-fat versus high- carbohydrate meal in healthy men. Clinical Endocrinology, 68: 890-897. Fan, J., Cotter, J.D., Lucas, R., Thomas, K., Wilson, L., & Ainslie, P.N. (2008) Human cardiorespiratory and cerebrovascular function during severe passive hyperthermia: effects of mild hypohydration. Journal of Applied Physiology, 105: 433-445. Han, S-K., & Herbison, A.E. (2008) Norepinephrine suppresses gonadotropin-releasing hormone neuron excitability in the adult mouse. Endocrinology, 149(3): 1129-1135. Herbison, A.E. (2008) Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: The case for the rostral periventricular area of the third ventricle (RP3V). Brain Research Reviews, 57(2): 277-287. Herbison, A.E., Porteous, R., Pape, J-R., Mora, J.M., & Hurst, P.R. (2008) Gonadotropin-releasing hormone neuron requirements for puberty, ovulation, and fertility. Endocrinology, 149(2): 597-604. Leng, G., Brown, C., Sabatier, N., & Scott, V. (2008) Population dynamics in vasopressin cells. Neuroendocrinology, 88(3): 160-172. Kwakowsky, A., Schwirtlich, M., Kooy, F., Ábrahám, I., Máté, Z., Katarova, Z., & Szabó, G. (2008) GABA neurotransmitter signaling in the developing mouse lens: Dynamic regulation of components and functionality. Developmental Dynamics, 237: 3830-3841. Liu, X., Popescu, I.R., Denisova, J.V., Neve, R.L., Corriveau, R.A., & Belousov, A.B. (2008) Regulation of cholinergic phenotype in developing neurons. Journal of Neurophysiology, 99: 2443-2455. Liu, X., & Herbison, A.E. (2008) Small-conductance calcium-activated potassium (SK) channels control excitability and firing dynamics in gonadotropin-releasing hormone (GnRH) neurons. Endocrinology, 149(7): 3598-3604. Lucas, R.A.I., Cotter, J.D., Morrison, S., & Ainslie, P.N. (2008) The effects of ageing and passive heating on cardiorespiratory and cerebrovascular responses to orthostatic stress in humans. Experimental Physiology, 93: 1104-1117.

196 RESEARCH REPORT 2007/2008 Lucas, S.J.E., Cotter, J.D., Murrell, C., Wilson, L., Anson, J.G., Gaze, D., George, K.P., & Ainslie, P.N. (2008) Mechanisms of orthostatic intolerance following very prolonged exercise. Journal of Applied Physiology, 105: 213-225. Liu, X., Lee, K., & Herbison, A.E. (2008) Kisspeptin excites gonadotropin-releasing hormone (GnRH) neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology, 149(9): 4605-4614. Mabuchi, A., Nagao, T., Koshio, O., Ishiwata, T., Yano, A., Suzuki, K., Yokomuro, K., & Wheatley, A.M. (2008) Role of F4/80+Mac-1high adherent non-parenchymal liver cells in Con A induced hepatic injury in mice. Hepatology Research, 38(10): 1040-1049. Marshall, H., Hamlin, M., Hellemans, J., Hellemans, I., Murrell, C., Beattie, N., & Ainslie, P.N. (2008) Effects of intermittent hypoxia on SaO2, cerebral and muscle oxygenation during maximal exercise in athletes with exercise-induced hypoxemia. European Journal of Applied Physiology, 104: 383-393. McDonald, F.J. (2008) A new SGK1 knockout mouse. American Journal of Physiology Renal Physiology, 294: F1296-F1297. Merry, T.L, Ainslie, P.N., Walker, R., & Cotter, J.D. (2008) Improved fluid regulation with aerobic fitness. Physiology and Behavior, 95: 348-352. Ogoh, S., Hayashi, N., Inagaki, M., Ainslie, P.N., & Miyamoto, Y. (2008) Interaction between the ventilatory and cerebrovascular responses to hypo- and hypercapnia at rest and during exercise. Journal of Physiology, 586: 4327-4338. Pan, W-X., Schmidt, R., Wickens, J.R., & Hyland, B.I. (2008) Tripartite mechanism of extinction suggested by dopamine neuron activity and temporal difference model. Journal of Neuroscience, 28(39): 9619-9631. Peebles, K., Richards, A.M., Celi, L., McGrattan, K., Murrell, C., & Ainslie, P.N. (2008). Human cerebral arterio-venous vasoactive exchange during alterations in arterial blood gases. Journal of Applied Physiology, 105: 1060-1068. Peng, T., Ainslie, P.N., Cotter, J.D., Murrell, C., Thomas, K., Williams, M.J.A., George, K., Shave, R., Rowley, A.G., & Payne, S.J. (2008) The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics. Physiological Measurement, 29: 1055-1069. Peng, T., Rowley, A.B., Ainslie, P.N., Poulin, M.J., & Payne, S.J. (2008) Multivariate system identification for cerebral autoregulation. Annals of Biomedical Engineering, 36: 308-320. Roberts, C.B., Campbell, R.E., Herbison, A.E., & Suter, K.J. (2008) Dendritic action potential initiation in hypothalamic gonadotropin-releasing hormone neurons. Endocrinology, 149(7): 3355-3360. Romanò, N., Lee, K., Ábrahám, I.M., Jasoni, C.L., & Herbison, A.E. (2008). Non-classical estrogen modulation of presynaptic GABA terminal modulates calcium dynamics in gonadotropin-releasing hormone neurons. Endocrinology, 149(11): 5335- 5344. Schwenke, D.O., Pearson, J.T., Kangawa, K., Umetani, K., & Shirai, M. (2008) Changes in macrovessel pulmonary blood flow distribution following chronic hypoxia: assessed using synchrotron radiation microangiograph. Journal of Applied Physiology, 104: 88-96. Schwenke, D.O., Tokudome, T., Kishimoto, I., Horio, T., Shirai, M., Cragg, P.A., & Kangawa, K. (2008). Early ghrelin treatment following myocardial infarction prevents an increase in cardiac sympathetic tone and reduces mortality. Endocrinology, 149(10): 5172-5176. Shirai, M., Schwenke, D.O., Eppel, G.A., Evans, R.G., Edgley, A.J., Tsuchimochi, H., Umetani, K., & Pearson, J.T. (2008). Synchrotron-based angiography for investigation of the regulation of vasomotor function in the microcirculation in vivo. Clinical and Experimental Pharmacology and Physiology, 2008 Oct 15. Epub ahead of print. Soeki, T., Kishimoto, I., Schwenke, D.O., Tokudome, T., Horio, T., Yoshida, M., Hosoda, H., & Kangawa, K. (2008) Ghrelin suppresses cardiac sympathetic activity and prevents early left ventricular remodeling in rats with myocardial infarction. American Journal of Physiology, 294: H426-H432. Stamp, L.K., Easson, A., Lehnigk, U., Highton, J., & Hessian, P.A. (2008) Different T cell subsets in the nodule and synovial membrane. Arthritis & Rheumatism, 58(6): 1601-1608. Tokudome, T., Kishimoto, I., Horio, T., Arai, Y., Schwenke, D.O., Hino, J., Okano, I., Kawano, Y., Kohno, M., Miyazoto, M., Nakao, K., & Kangawa, K. (2008) Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart. Circulation, 117: 2329-2339. Woolley, A.G., Tait, K.J., Hurren, B.J., Fisher, L., Sheard, P.W., & Duxson, M.J. (2008) Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. Glia 56: 306-317.

Journal – Research Other Ainslie, P.N. (2008) Cardiorespiratory fitness: A simple, cheap and non-pharmacological means to prevent stroke? Stroke, 2008 Dec 4. Epub ahead of print.

Division of HEALTH SCIENCES 197 DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF GENERAL PRACTICE

Edited Book – Other Storr E, Nicholls G, Lea A, Leigh M, & McMain S. (2008) General Practice: Clinical Cases Uncovered. Wiley Blackwell: Bognor Regis.

Journal – Research Article Cunningham W. (2008) Being a professional general practitioner and using principles of professionalism to consider workforce issues in general practice. New Zealand Family Physician, 35(3). Dovey S. (2008) Patient-centred professionalism and population health: Negotiating the tension. NZ Fam Physician, 35(3), 154-5. Elley CR, Robertson MC, Garrett S, Kerse NM, McKinlay E, Lawton B, Moriarty H, Moyes S, Campbell AJ. (2008) Effectiveness of a falls-and-fracture nurse coordinator to reduce falls: A randomized controlled trial of at-risk older adults. Journal of the American Geriatrics Society, 56, 1383-1389. Garrett S, Elley CR, O’Dea D. (2008) The cost of falls in older adults in the community. New Zealand Family Physician, 35(1), 22-27. Hickner J, Graham DG, Elder NC, Brandt E, Emsermann CB, Dovey S, Phillips R. (2008) Testing process errors and their harms and consequences reported from family medicine practices: a study of the American Academy of Family Physicians National Research Network. Quality and Safety in Healthcare, 17, 194-200. Holland D, Booy R, De Looze F, Eizenberg P, McDonald J, Karrasch J, McKeirnan M, Salem H, Mills G, Reid J, Weber F, Saville M. (2008) Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: randomized controlled trial. Journal of Infectious Diseases, 198 (1 Sept) 650-658. Menkes DB, Hill CJ, Horsfall M, Jaye C. (2008) Perspectives on access to personal health information in New Zealand/ Aotearoa. Anthropology & Medicine, 15(3), 199-212. Nixon G. (2008) Medical emergencies in rural practice. New Zealand Family Physician, 34(6), 419-421. Park, J, McLauchlan L, and Frengley E. Research in Anthropology and Linguistics-e 2, 2008. 40 pp. Department of Anthropology, University of Auckland. Park, J, McLauchlan L, and Frengley E (2008). The Social Ecology of New Technologies and Haemophilia in New Zealand: A Bleeding Nuisance Revisited. Park J, and York D. Research in Anthropology and Linguistics Monograph No. 8, 2008. 69 pp. Department of Anthropology, University of Auckland. Sites New Series 5(1):159-162. Plumridge E, Goodyear-Smith FA, Ross J. (2008) Parents and nurses during the immunization of children – where is the power? A conversation analysis. Family Practice Advance Access, 14 February. Tomlin AM, Dovey S, Tilyard M. (2008) Risk factors for hospitalization due to diabetes complications. Diabetes Research and Clinical Practice, 80, 244-252. Wallis K. (2008) Severe vitamin D deficiency presenting as hypocalcaemic seizures in a black infant at 45.5 degrees south. Cases Journal, 1(12). Wallis K. (2008) New Zealand’s cervical screening legislation – and response. New Zealand Medical Journal, 121(1268). Wilson H, (2008) Becoming ‘patient-centred’: a review. New Zealand Family Physician, 35(3). Wallis K. (2008) Health information privacy: The patient perspective. New Zealand Family Physician, 35(3), 171-174.

DUNEDIN SCHOOL OF MEDICINE ANAESTHESIA AND INTENSIVE CARE SECTION

Journal – Research Article Ainslie PN, Celi L, McGrattan K, Peebles K, Ogoh S. Dynamic cerebral autoregulation and baroreflex sensitivity during modest

and severe step changes in arterial PCO2. Brain Res. 2008 Sep 16;1230:115-24. Ainslie PN, Ogoh S, Burgess K, Celi L, McGrattan K, Peebles K, Murrell C, Subedi P, Burgess KR. Differential effects of acute hypoxia and high altitude on cerebral blood flow velocity and dynamic cerebral autoregulation: alterations with hyperoxia. J Appl Physiol. 2008 Feb;104(2):490-8. Glasgow JL, McLennan SR, High KJ, Celi LA. Quality of dying in a New Zealand teaching hospital. Qual Saf Health Care. 2008 Aug;17(4):244-8. Khan E, Huggan P, Celi L, MacGinley R, Schollum J, Walker R. Sustained low-efficiency dialysis with filtration (SLEDD-f) in the management of acute sodium valproate intoxication. Hemodial Int. 2008 Apr;12(2):211-4. McLennan S, Gillett G, Celi LA. Healer, heal thyself: health care workers and the influenza vaccination. Am J Infect Control. 2008 Feb;36(1):1-4. Review. Peebles KC, Richards AM, Celi L, McGrattan K, Murrell CJ, Ainslie PN. Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. J Appl Physiol. 2008 Oct;105(4):1060-8. Reith D, Medlicott NJ, Kumara De Silva R, Yang L, Hickling J, Zacharias M. Simultaneous modelling of the Michaelis-Menten kinetics of paracetamol sulphation and glucuronidation. Clin Exp Pharmacol Physiol. 2008 Epub Aug 26. Zacharias M, Conlon NP, Herbison GP, Sivalingam P, Walker RJ, Hovhannisyan K. Interventions for protecting renal function in the perioperative period. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD003590. Review.

198 RESEARCH REPORT 2007/2008 DUNEDIN SCHOOL OF MEDICINE BIOETHICS CENTRE

Book Evans, D M. (2008) ‘Values in Medicine: what are we really doing to patients?’ Routledge-Cavendish, London and New York. Gillett, G. (2008) Subjectivity and Being somebody: human identity, and neuroethics (St Andrews Philosophy and public Affairs series) Exeter: Imprint Academic.

Chapter in Book Gillett, G. (with M.Harrigan) ‘Hunting good will in the wilderness’ in Decision making, personhood and dementia: Examining the interface (ed D O’Connor & B Purves) London: Jessica Langley. 2008 Gillett, G. Ch 34. ‘Surgical innovation and research’ in Oxford Textbook of Clinical Research Ethics Oxford: University Press 2008; pp367-376. Nie, JB. 2008. “Medical Ethics through the Life Cycle in China,” in Robert Baker and Larry McCullough, eds., The Cambridge World History of Medical Ethics, New York and London: Cambridge University Press. Nie, JB. 2008. “The Discourses of Practitioners in China,” in Robert Baker and Larry McCullough, eds., The Cambridge World History of Medical Ethics, New York and London: Cambridge University Press. Nie, JB, Takashi Tsuchiya and Lun Li. 2008. “Japanese Doctors’ Human Experimentation in Wartime China and its Challenges for Contemporary Medical Ethics.” in Robert Baker and Larry McCullough, eds., The Cambridge World History of Medical Ethics, New York and London: Cambridge University Press. Nie, JB. 2008. “Exploring the Core of Humanity: Cross-Cultural Perspectives on the Concept of Personhood.” In Tze-wan Kwan, ed., Responsibility and Commitment: Eighteen Essays in Honor of Gerhold K. Becker. Waldkirch: Edition Gorz, pp. 17-27.

Journal – Research Article Anderson, L. & Pickering, N. (2008) Ethical review of physiotherapy research. New Zealand Journal of Physiotherapy. Volume 36: Number 3 (Nov 2008). Anderson, L. (2008) Contractual obligations and the sharing of confidential health information in sport. J Med Ethics 2008; 34:e6 http://jme.bmj.com/cgi/content/full/34/9/e6 Cohen CB, Brandhorst B, Nagy A, Leader A, Dickens B, Isasi RM, Evans D, Knoppers BM. (2008). The use of fresh embryos in stem cell research: ethical and policy issues. Cell Stem Cell. 2(5):416-21. Gillett, G. ‘Autonomy and selfishness’ Lancet (Oct 04, 2008); vol 372, no 9645 pp1214-15. Gillett, G. ‘Ethical decisions at the edge’ Journal of Law and Medicine 15.5;686-92 (2008). Gillett, G. Identity and resurrection The Heythrop Journal XLIX 254-68 (2008). Gillett, G. (with Matthew Gillett) Intent, the ethos of a caring society, and justice. Journal of Law and Medicine (2008) 16,2, pp209-15 Gillett, G. (with Sarah Jones) Posthumous reproduction: consent and its limitations. Journal of Law and Medicine (2008) 16.2, pp279-87. King, M.R., P.C.H. Morel, D.K. Revell, J.R. Pluske, and M.J. Birtles, 2008. Dietary bovine colostrum increases villus height and decreases small intestine weight in early-weaned pigs. Asian-Australasian Journal of Animal Science 21: 567-573. King, M.R., P.C.H. Morel, J.R. Pluske and W.H. Hendriks, 2008. A comparison of the effects of dietary spray-dried bovine colostrum and animal plasma on growth and intestinal histology in weaner pigs. Livestock Science 119: 167-173. McLennan S, Gillett G, Celi LA.(2008). Healer, heal thyself: health care workers and the influenza vaccination. Am J Infect Control. 36(1):1-4. Pickering, N. (2008) The importance of not being complementary [Perspectives The Art of Medicine] The Lancet Volume 372, Nov. 29, pp.1874-5 Wensley, D. and M.R. King 2008. Scientific responsibility for the dissemination and interpretation of genetic research: Lessons from the ‘Warrior Gene’ controversy. Journal of Medical Ethics 34, 507-509.

Journal – Other Evans, D M. Electronically Stored Health Data and Best Practice – Opinion Piece, 2008, Health [e] News, Ministry of Health NZ, 19 June, pp 8-9. Gillett, G. ‘Dialoguing The Exorcism of Emily Rose’ Dialogue Australasia. Issue 20, 26-29, 2008.

Division of HEALTH SCIENCES 199 DUNEDIN SCHOOL OF MEDICINE MEDICINE SECTION

Journal – Research Article Ainslie PN, Cotter JD, George KP, Lucas S, Murrell C, Shave R, Thomas KN, Williams MJ, Atkinson G. Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageing. Journal of Physiology 2008;586(16):4005-10. Annapoorna S. Kini, MD, Victor H. T. Chen, FRACP, Prakash Krishnan, MD, Paul Lee, MD, Michael C. Kim, MD, Angelica Mares, MD, Javed Suleman, MD, Pedro R. Moreno, MD, and Samin K. Sharma, MD New York, NY. Bolus-only versus bolus + infusion of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. Am Heart J 2008; 156:513-9. Bedford JJ, Leader JP, Jing R, Walker LJ, Klein JD, Sands JM, Walker RJ. Amiloride restores renal medullary osmolytes in lithium- induced nephrogenic diabetes insipidus. American Journal of Physiology – Renal Physiology 2008;294(4):F812-20. Bedford JJ, Weggery S, Ellis G, McDonald FJ, Joyce PR, Leader JP, Walker RJ. Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride. Clinical Journal of The American Society of Nephrology: CJASN 2008;3(5):1324-31. Booker CS, Mann JI. Trans fatty acids and cardiovascular health: translation of the evidence base. Nutrition Metabolism & Cardiovascular Diseases 2008;18(6):448-56. Chan G, Goh F, Hodgson T, Hsu E, Johnstone D, Ly J, Platt T, Rodrigues E, Tsai W, Hider P, Gray A, Highton J. Outpatient follow-up for patients with rheumatoid arthritis in relation to New Zealand Rheumatology Association guidelines at Dunedin Hospital. New Zealand Medical Journal 2008;121(1274):34-41. Chu JW, Levine RA, Chua S, Poh KK, Morris E, Hua L, Ton-Nu TT, Hung J. Assessing mitral valve area and orifice geometry in calcific mitral stenosis: a new solution by real-time three-dimensional echocardiography. J Am Soc Echocardiogr. 2008 Sep;21(9):1006-9. Coppell K, Williams S, Anderson K, Lamb C, Mann J. Characteristics and cardiovascular risk of new cases of type 2 diabetes in Otago, New Zealand, 1998–2004. Diabetes Res Clin Pract. 2008; 82(3):396-401. De Silva ML, McLaughlin MT, Rodrigues EJ, Broadbent JC, Gray AR, Hammond-Tooke GD. A Mini-Mental Status Examination for the hearing impaired. Age and Ageing 2008;37(5):593-5. Elley CR, Robertson MC, Garrett S, Kerse NM, McKinlay E, Lawton B, Moriarty H, Moyes SA, Campbell AJ. Effectiveness of a falls-and-fracture nurse coordinator to reduce falls: a randomized, controlled trial of at-risk older adults. Journal of the American Geriatrics Society 2008;56(8):1383-9. Findlay, M.P., K.J. Sharples, P.I. Thompson, D.J. Perez, J. Adams, R. Isaacs, B. Robinson, V.A. Hinder, S. Pollard, A.E. O‘Donnell. A Phase II study of capecitabine, oxaliplatin and bevacizumab using a 2-weekly schedule in previously untreated patients with advanced, unresectable colorectal cancer – Cancer Trials New Zealand Study 05-6. Annals of Oncology 19, Supplement 8, September 2008. Gerrard DF. Drug misuse in sport: what the future holds. NZMJ 121: 1278 1-4 (2008) Gerrard D.F. Playing Foreign Policy Games: States drugs and other Olympian vices. Sport in Society. 11:4 459-466 (2008) Gerrard DF, Children in aquatic sport: a shared clinical responsibility. Sixteenth FINA World Sports Medicine Congress. J Sport Sciences 26(1): 3-21(2008) Goulding A, Grant AM, Williams SM. Bone fractures in children: impact of fat and lean mass. International Journal of Body Composition Research 2008; 6: (4) 149-158 Goulding A, Taylor RW, Grant AM, Murdoch L, Taylor BJ, Williams SM. Relationship of total body fat mass to bone area in New Zealand five-year-olds Calcified Tissue International 2008; 82:293-299 Grant AM, Taungapeau FK, McAuley KA, Taylor RW, Williams SM, Waldron MA, Duncan AW, Harper MJ, Goulding A. Body mass index status is effective in identifying metabolic syndrome components and insulin resistance in Pacific Island teenagers living in New Zealand. Metabolism: Clinical and Experimental 2008;57(4):511-6. Gwynne Jones DP, Savage RL, Highton J. Alendronate-induced synovitis. Journal of Rheumatology 2008;35(3):537-8. Hancox RJ, Welch D, Poulton R, Taylor DR, McLachlan CR, Greene JM, Sears MR. Cigarette smoking and allergic sensitization: a 32-year population-based cohort study. Journal of Allergy & Clinical Immunology 2008;121(1):38-42 e3. Hewitt RS, Modrich CM, Medlicott T, Cowan JO, Taylor DR. Supporting the diagnosis of non-specific respiratory symptoms in primary care: the role of exhaled nitric oxide measurement and spirometry. Primary Care Respiratory Journal 2008;17(2):97-103. Hewitt RS, Smith AD, Cowan JO, Schofield JC, Herbison GP, Taylor DR. Serial exhaled nitric oxide measurements in the assessment of laboratory animal allergy. Journal of Asthma 2008;45(2):101-7. Kiata L, Kerse NM, Hughes WE, Hayman KJ, Robertson MC, La Grow SJ, Campbell AJ. Agreement and compliance with advice on removing mats or rugs by older people with visual impairments. J Vis Impair Blind 2008;2:167-72. Kanzaki M, Mochizuki H, Ogawa G, Tanaka K, Araki M, Motoyoshi K, Hammond-Tooke G, Kamakura K. Clinical features of opticospinal multiple sclerosis with anti-aquaporin 4 antibody. European Neurology 2008;60(1):37-42. Lean ME, Mann JI, Hoek JA, Elliot RM, Schofield G. Translational research. BMJ 2008;337:a863. Lotz TF, Chase JG, McAuley KA, Shaw GM, Wong XW, Lin J, Lecompte A, Hann CE, Mann JI. Monte Carlo analysis of a new model-based method for insulin sensitivity testing. Computer Methods & Programs in Biomedicine 2008;89(3):215-25. Lucas SJ, Anglem N, Roberts WS, Anson JG, Palmer CD, Walker RJ, Cook CJ, Cotter JD. Intensity and physiological strain of competitive ultra-endurance exercise in humans. Journal of Sports Sciences 2008;26(5):477-89. Manning PJ, Sutherland WH, Walker RJ, de Jong SA, Berry EA. The effect of glucose ingestion on inflammation and oxidative stress in obese individuals. Metabolism: Clinical & Experimental 2008;57(10):1345-9.

200 RESEARCH REPORT 2007/2008 Manning PJ, Sutherland WH, Walker RJ, Williams SM, de Jong SA, Berry EA. The effect of rosiglitazone on oxidative stress and insulin resistance in overweight individuals. Diabetes Research & Clinical Practice 2008;81(2):209-15. Manning PJ, Sutherland WH, Walker RJ, de Jong SA, , Berry EA. Postprandial cytokine concentrations and meal composition in obese and lean women. Obesity 2008 Jun 26. [Epub ahead of print]. Marshall HC, Hamlin MJ, Hellemans J, Murrell C, Beattie N, Hellemans I, Perry T, Burns A, Ainslie PN. Effects of intermittent hypoxia on SaO(2), cerebral and muscle oxygenation during maximal exercise in athletes with exercise-induced hypoxemia. European Journal of Applied Physiology 2008;104(2):383-93. McKinney C, Merriman ME, Chapman PT, Gow PJ, Harrison AA, Highton J, Jones PB, McLean L, O’Donnell JL, Pokorny V, Spellerberg M, Stamp LK, Willis J, Steer S, Merriman TR. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Annals of the Rheumatic Diseases 2008;67(3):409-13. Mountjoy M, Armstrong N, Bizzinni L, Blimkie C, Evans J, Gerrard DF et al, IOC Consensus on Training the Elite Child Athlete. Clin J Sport Med 18(2):122-123, (2008) Ng CS, Wei W, Doyle TC, Courtney HM, Dixon AK, Freeman AH. Minimal-preparation abdomino-pelvic CT in frail and elderly patients: prognostic value of colonic and extracolonic findings. Clinical Radiology 2008;63(4):424-32. Oldham JM, Osepchook CC, Jeanplong F, FJ, Falconer SJ, Matthews K, Conaglen JV, Gerrard DF, Smith HK, Wilkins RJ, JB Bass, McMahon CD. The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone. Accepted for publication, Journal of Physiology 2008 Dec 1. [Epub ahead of print]. Pavord ID, Shaw DE, Gibson PG, Taylor DR. Inflammometry to assess airway diseases. Lancet 2008;372(9643):1017-9. Peng T, Ainslie PN, Cotter JD, Murrell C, Thomas K, Williams MJ, George K, Shave R, Rowley AB, Payne SJ. The effects of age on the spontaneous low-frequency oscillations in cerebral and systemic cardiovascular dynamics. Physiological Measurement 2008;29(9):1055-69. Schultz M. Clinical use of E. coli Nissle 1917 in inflammatory bowel disease. Inflammatory Bowel Diseases 2008;14(7):1012-8. Schultz M, Butt GA. Probiotic therapy in Inflammatory Bowel Disease – Why they should work! Probiotica 2008;24:4-6 Schultz M, AL Lindstrom. Invited Review: The use of probiotics in IBD. Exp Rev Gastroenterol Hepatol 2008;2(3):337-356 Schultz M. Invited Review: Clinical use of the Probiotic E. coli Nissle for IBD. Inflam Bowel Dis 2008;14(7):1012-1018 Slatter TL, Jones GT, Williams MJ, van Rij AM, McCormick SP. Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics 2008;73(2):179-84. Stamp LK, Easson A, Lehnigk U, Highton J, Hessian PA. Different T cell subsets in the nodule and synovial membrane: absence of interleukin-17A in rheumatoid nodules. Arthritis and Rheumatism 2008;58(6):1601-8. Sutherland TJ, Cowan JO, Taylor DR. Dynamic hyperinflation with bronchoconstriction: differences between obese and nonobese women with asthma. American Journal of Respiratory and Critical Care Medicine 2008;177(9):970-5. Sutherland TJ, Cowan JO, Young S, Goulding A, Grant AM, Williamson A, Brassett K, Herbison GP, Taylor DR. The association between obesity and asthma: interactions between systemic and airway inflammation. American Journal of Respiratory and Critical Care Medicine 2008;178(5):469-75. Sutherland TJ, Goulding A, Grant AM, Cowan JO, Williamson A, Williams SM, Skinner MA, Taylor DR. The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function. European Respiratory Journal 2008;32(1):85-91. Taylor DR, Hall IP. ADRB2 polymorphisms and beta2 agonists. Lancet 2008;370(9605):2075-6. Taylor WJ, Harrison AA, Highton J, Chapman P, Stamp L, Dockerty J, McQueen F, Jones PB, Ching D, Porter D, Rajapakse C, Rudge SR, Taylor G, Kumar S, Macedo T, Hoy MS. Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement. Rheumatology 2008;47(4):514-8. Taylor RW, Williams SM, Grant AM, Ferguson E, Taylor BJ, Goulding A. Waist circumference as a measure of trunk fat mass in children aged 3 to 5 years. International Journal of Pediatric Obesity 2008; 3 (4) 226-233 (2008). Turley AJ, Chen V, Hall JA. Simultaneous presentation of coronary heart disease in identical twins. Postgraduate Medical Journal 2008; 84; 100–2. Williams SM, Venn BJ, Perry T, Brown R, Wallace A, Mann JI, Green TJ. Another approach to estimating the reliability of glycaemic index. British Journal of Nutrition 2008;100(2):364-72. Wong CK, Herbison P, Tang EW. Relation between blood pressure at hospital discharge after an acute coronary syndrome and long-term survival. American Journal of Cardiology 2008;101(9):1239-41. Wong CK, Tang EW, Herbison P, Birmingham B, Barclay L, Fu SY. Pre-existent depression in the 2 weeks before an acute coronary syndrome can be associated with delayed presentation of the heart attack. Qjm 2008;101(2):137-44. Woodley SJ, Nicholson HD, Livingstone V, Doyle TC, Meikle GR, Macintosh JE, Mercer SR. Lateral hip pain: findings from magnetic resonance imaging and clinical examination. Journal of Orthopaedic & Sports Physical Therapy 2008;38(6):313-28.

Division of HEALTH SCIENCES 201 DUNEDIN SCHOOL OF MEDICINE OPHTHALMOLOGY SECTION

Chapter in Book Molteno ACB, Bevin TH. (2008). Double-plate Molteno implants. In: Surgical Techniques in Ophthalmology: Glaucoma Surgery. Chen T.C. (ed). Philadelphia: Elsevier, pp. 123-141.

Journal – Research Article Bevin TH, Molteno AC, Herbison P. Otago Glaucoma Surgery Outcome Study: long-term results of 814 trabeculectomies. Clin Exp Ophthalmol 2008; 36:731-7. Rahman AM, Molteno T, Molteno AC. (2008). Fourier analysis of digital retinal images in estimation of cataract severity. Clinical and Experimental Ophthalmology, 36:637-45. Toh, TY, Bevin TH, Molteno AC. Scleral wrap increases the long-term complication risk of bone-derived hydroxyapatite orbital implants. Clin Exp Ophthalmol 2008; 36:756-61. Vaegan, Rahman AMA, Sanderson GF. (2008). Glaucoma affects steady state VEP contrast thresholds before psychophysics. Optometry and Vision Science; 85: 547-558.

DUNEDIN SCHOOL OF MEDICINE ORTHOPAEDIC SURGERY SECTION

Journal – Research Article Barz T, Melloh M, Staub L, Roeder C, Lange J, Smiszek FG, Theis JC, Merk HR. The diagnostic value of a treadmill test in predicting lumbar spinal stenosis. Eur Spine J. 2008 May;17(5):686-90. Gwynne-Jones DP, Draffin J, Vane AG, Craig RA, McMahon SF. Failure strengths of concentric and eccentric implants for hamstring graft fixation. ANZ J Surg. 2008 Mar;78(3):177-81. Gwynne-Jones DP, Hartnett NI. Aberrant radial artery seen in the carpal tunnel at carpal tunnel decompression: case report. J Hand Surg [Am]. 2008 Jul-Aug;33(6):885-7. Gwynne-Jones D, Lyall P, Hung NA, Meikle G. Accidental human injection of Excenel RTU: ceftiofur hydrochloride in cottonseed oil. Clin Toxicol (Phila). 2008 Nov;46(9):908-10. Gwynne-Jones DP, McMahon SF. Failure strengths of concentric and eccentric implants for hamstring graft fixation. ANZ J Surg. 2008 Oct;78(10):929. Gwynne Jones DP, Savage RL, Highton J. Alendronate-induced synovitis. J Rheumatol. 2008 Mar;35(3):537-8 Leigh W, O’Grady P, Lawson EM, Hung NA, Theis JC, Matheson J. Pelvic pseudotumor: an unusual presentation of an extra- articular granuloma in a well-fixed total hip arthroplasty. J Arthroplasty. 2008 Sep;23(6):934-8. Melloh M, Aebli N, Elfering A, Roder C, Zweig T, Barz T, Herbison P, Hendrick P, Bajracharya S, Stout K, Theis JC. Development of a screening tool predicting the transition from acute to chronic low back pain for patients in a GP setting: Protocol of a multinational prospective cohort study. BMC Musculoskelet Disord. 2008 Dec 19;9(1):167. Melloh M, Röder C, Elfering A, Theis JC, Müller U, Staub LP, Aghayev E, Zweig T, Barz T, Kohlmann T, Wieser S, Jani P, Zwahlen M. Differences across health care systems in outcome and cost-utility of surgical and conservative treatment of chronic low back pain: a study protocol. BMC Musculoskelet Disord. 2008 Jun 6;9:81. Melloh M, Staub L, Aghayev E, Zweig T, Barz T, Theis JC, Chavanne A, Grob D, Aebi M, Röder C. The international spine registry SPINE TANGO: status quo and first results. Eur Spine J. 2008 Sep;17(9):1201-9. Epub 2008 Apr 30. Pai VS, Hodgson B. Repair of spondylolytic defect with a cable screw reconstruction. Int Orthop 2008 Feb:32(1):121-5. Theis JC. Implant retention in infected joint replacements: a surgeon’s perspective. Int J Artif Organs. 2008 Sep;31(9):804-9. Theis JC, Louahem D, Dimeglio A. Total posterior condylar separation in a juvenile knee: open fixation through a posterior arthrotomy. Arch Orthop Trauma Surg. 2008 Nov 29. Epub ahead of print. Tong D, Theis JC. Antibiotic prophylaxis and invasive dental treatment in prosthetic joint patients. NZ Med J. 2008 Aug 22;121(1280):45-52.

DUNEDIN SCHOOL OF MEDICINE SURGERY SECTION

Hand Booklet Dickinson, I., Maddern, G., Edwards, M., van Rij, A., Woodruff, P., Graham, J., Watters, D., Martin, J., Grigg, M., Alley, P., Williams, S., Roberts, A., Speck, G., Cain, C., Rait, J., Quinn, J., Simpson, J., Collins, J., Montgomery, P., Graham, I., Crebbin, W. (2008). The Royal Australasian College of Surgeons Surgical Competence and Performance.

Journal – Research Article Anjomshoaa, A., Lin, Y-H., Black, MA., McCall, JL., Humar, B., Song, S., Fukuzawa, R., Yoon, H-S., Holzmann, B., Friederichs, J., van Rij, A., Thompson-Fawcett, M., Reeve, AE. (2008). Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. British Journal of Cancer. 99(6): 966-973.

202 RESEARCH REPORT 2007/2008 Grant, M.W., Thomson, I.A., van Rij, A.M. (2008) In-Hospital Mortality of Ruptured Abdominal Aortic Aneurysm. ANZ Journal of Surgery. 78:698-704. Helgadottir A, Thorleifsson G, Magnusson KP, et. (including van Rij AM). (2008). The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nature Genetics 40:217-224. Jones, G.T. (2008). Animal models in chronic venous disease. Medicographia 30(2);154-156. Jones, G. T. Thompson, A. R. van Bockxmeer, F. M. Hafez, H. Cooper, J. A. Golledge, J. Humphries, S. E. Norman, P. E. van Rij, A. M. Angiotensin II type 1 receptor 1166C polymorphism is associated with abdominal aortic aneurysm in three independent cohorts. Arterioscler Thrombosis and Vascular Biology 28: 764-770 (2008) Jones, G.T, van Rij, A.M, Hill, G.B, Wilkins, G.T, Williams, M.J.A. (2008). Common Carotid Intimal-medial Thickness Is Associated with Coronary In-stent Restenosis. The Journal for Vascular Ultrasound. 32(3):129-132. Lauti, M., Scott, D., Thompson-Fawcett, M.W. (2008). Fibre supplementation in addition to loperamide for faecal incontinence in adults: a randomised trial. The Association of Coloproctology of Great Britain and Ireland Colorectal Disease. 10:553-562. Pascoe, K.C. Wlodek, M.E. Jones, G.T. (2008). Increased elastic tissue defect formation in the growth restricted Brown Norway rat: a potential link between in utero condition and cardiovascular disease? Paediatric Research. 64:125-130. Raymount, A., Morgan, S., McLeod, D., Dowell, A., van Rij, A., Cumming, J., Pledger, M., Dew, K., Cormack, D. (2008). New Zealand general practioners’ non-urgent referrals to surgeons: who and why? New Zealand Medical Journal. 121: 57-64. Richter, K.K., Schmid, C., Thompson-Fawcett, M., Settmacher, U., Altendorf-Hofmann, A. (2008). Long-term follow-up in 54 surgically treated patients with gastrointestinal stromal tumors. Langenbeck’s Archives of Surgery. Rudland, J., Wilkinson, T., Smith-Han, K., Thompson-Fawcett, M. (2008). “You can do it late at night or in the morning. You can do it at home, I did it with my flatmate.” The educational impact of an OSCE. Medical Teacher 30:206-211. Slatter, T.L., Jones, G.T., Williams, M.J.A., van Rij, A.M., McCormick, S.P.A. (2008). Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clinical Genetics 73:179-184. Thorgeirsson TE, Geller F, Sulem et. al (including Jones GT, and van Rij AM). (2008). A Variant Associating with Nicotine Dependence, Lung Cancer and Peripheral Arterial Disease. Nature 452(3); 638-642. van Rij, A.M., Alwis, C.S., Jiany, P., Christie, G.B., Dutton, S.J., Thomson, I.A. (2008). Obesity and Impaired Venous Function. European Journal of Vascular and Endovascular Surgery 35: 739-744. van Rij A.M., Jones G.T., Hill G.B., Amer M., Thomson I.A., Pettigrew I.A., Packer S.G.K. (2008). Mechanical inhibition of angiogenesis at the saphenofemoral junction in the surgical treatment of varicose veins: early results of a blinded randomised controlled trial. Circulation. 118:1-9. Wakeman, C.J., Dobbs, B.R., Frizelle, F.A., Bissett, I.P., Dennett, E.R., Hill, A.G., Thompson-Fawcett, M.W. (2008). The Impact of Splenectomy on Outcome After Resection for Colorectal Cancer: A Multicenter, Nested, Paired Cohort Study. Disease of the Colon & Rectum. 51:213-217.

DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF PATHOLOGY

Chapter in Book Eccles, MR. PAX2 and Renal-Coloboma Syndrome. In: Inborn Errors of Development 2nd edition (2008). C Epstein, R Erickson, A Wynshaw-Boris (Eds). Oxford Press, San Francisco.

Journal – Research Article Anjomshoaa A, Lin YH, Black MA, McCall JL, Humar B, Song S, Fukuzawa R, Yoon HS, Holzmann B, Friederichs J, et al. (2008). Reduced expression of a gene proliferation signature is associated with enhanced malignancy in colon cancer. Br J Cancer, Aug 26. Epub ahead of print. Chen YJ, Campbell HG, Wiles AK, Eccles MR, Reddel RR, Braithwaite AW, Royds JA: PAX8 regulates telomerase reverse transcriptase and telomerase RNA component in glioma. Cancer Res 2008, 68:5724-5732. Choi BH, Kim W, Wang QC, Kim DC, Tan SN, Yong JW, Kim KT, Yoon HS. (2008). Cancer Lett. 8;261(1):37-45. Frost V, Grocott T, Eccles MR, Chantry A. (2008). Self-Regulated Pax Gene Expression and Modulation by the TGFbeta Superfamily. Crit Rev Biochem Mol Biol. 2008 Nov 17:1. [Epub ahead of print] Gwynne-Jones D, Lyall P, Hung NA, Meikle G. (2008). Accidental human injection of Excenel RTU: ceftiofur hydrochloride in cottonseed oil. Clin Toxicol (Phila), 46(9):908-10. Hueber PA, Fukuzawa R, El-Kares R, Chu LL, Blumenkrantz M, He S, Anaka MR, Reeve AE, Eccles MR, Jabado N, et al. (2008). PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms Tumors with myogenic phenotype. Pediatr Dev Pathol, Jul 30:1. Epub ahead of print. Hueber PA, Iglesias D, Chu LL, Eccles M, Goodyer P. (2008). In vivo validation of PAX2 as a target for renal cancer therapy. Cancer Lett. 28;265(1):148-55. Legge M, Fitzgerald R, Jones L: An alternative consideration in drug testing in elite athletes. N Z Med J 2008, 121:73-77. Leigh W, O’Grady P, Lawson EM, Hung NA, Theis JC, Matheson J. (2008). Pelvic pseudotumor an unusual presentation of an extra-articular granuloma in a well-fixed total hip arthroplasty. J Arthroplasty. 23(6):934-8. Macartney-Coxson DP, Hood KA, Shi HJ, Ward T, Wiles A, O’Connor R, Hall DA, Lea RA, Royds JA, Stubbs RS, et al.: Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer 2008, 8:187.

Division of HEALTH SCIENCES 203 Phillips VK, Legge M, Jones LM: Maximal physiological responses between aquatic and land exercise in overweight women. Med Sci Sports Exerc 2008, 40:959-964. Sherwin CM, Svahn S, Broadbent RS, Van Der Linden A, Medlicott NJ, Reith DM. (2008). Netilmicin withdrawal: impact on neonates. N Z Med J. 17;121(1284):95-7. van Roij MH, Mizumoto S, Yamada S, Morgan T, Tan-Sindhunata MB, Meijers-Heijboer H, Verbeke JI, Markie D, Sugahara K, Robertson SP: Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype. Am J Med Genet A 2008, 146A:2376-2384. Wang YA, Johnson SK, Brown BL, McCarragher LM, Al-Sakkaf K, Royds JA, Dobson PR: Enhanced anti-cancer effect of a phosphatidylinositol-3 kinase inhibitor and doxorubicin on human breast epithelial cell lines with different p53 and oestrogen receptor status. Int J Cancer 2008, 123:1536-1544. Woolley AG, Tait KJ, Hurren BJ, Fisher L, Sheard PW, Duxson MJ. (2008). Developmental loss of NT-3 in vivo results in reduced levels of myelin-specific proteins, a reduced extent of myelination and increased apoptosis of Schwann cells. Glia. 56(3):306-17.

DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF PREVENTIVE AND SOCIAL MEDICINE

Chapter in Book Connor J. Chapter 12. The role of driver sleepiness in car crashes: a review of the epidemiological evidence, in Drugs, Driving and Traffic Safety. Basel: Birkhauser Verlag, 2008. Poulton R, Grisham JR, Andrews G. Developmental approaches to understanding anxiety disorders. In: Antony MM, Stein MB, editors. Oxford Handbook of Anxiety and Related Disorders. New York: Oxford University Press; 2008. p. 123-35. Robertson SP, Poulton R. Longitudinal studies of gene-environment interaction in common diseases – good value for money? In: Rutter SM, editor. Understanding how gene-environment interactions work to predict disorder: a lifecourse approach. London: John Wiley & Sons; 2008. p. 128-42.

Journal – Research Article Adetifa IMO, Hill PC, Jackson-Sillah DJ, Ibanga H, Bah G, Donkor SA, Corrah T, Adegbola RA. Haematological values from a Gambian cohort - possible reference ranges for a West African population. Int J Lab Hematology 2008; Jul 3. Epub ahead of print. Akerstedt T, Connor J, Gray A, Kecklund G. Predicting road crashes from a mathematical model of alertness regulation – The Sleep/Wake Predictor. Accident Analysis and Prevention, 2008;40:1480-5. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R and Cannabis and Respiratory Disease Research Group (2008). Cannabis use and cancer of the head and neck: Case-control study. Otolaryngology-Head and Neck Surgery, 138 (3): 374-380. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R, on behalf of the Cannabis and Respiratory Disease Research Group. Cannabis use and risk of lung cancer: a case-control study. Eur Resp J 2008; 31 (2): 280-286. Antonio M, Hakeem I, Awine T, Secka O, Sankareh K, Nsekpong D, Lahai G, Akisanya A, Egere U, Enwere G, Zaman SM, Hill PC, Corrah T, Cutts F, Greenwood BM, Adegbola RA. Seasonality and outbreak of a predominant Streptococcus pneumoniae serotype 1 clone from The Gambia: Expansion of ST217 hypervirulent clonal complex in West Africa. BMC Microbiol 2008; 8: 198 (epub). Begg, D. J. and Gulliver, P. (2008 ) A longitudinal examination of the relationship between adolescent problem behaviors and traffic crash involvement during young adulthood. Traffic Injury Prevention, 9(6), 508-14. Biau DJ, Williams SM, Schlup MM, Nizard RS, Porcher R. Quantitative and individualized assessment of the learning curve using LC-CUSUM. Br J Surg. 2008;95:925-9. Boyle P. Anderson BO. Andersson LC, et al. Need for global action for cancer control. Annals of Oncology. 2008; 19:1519-1521. Broadbent JM, Thomson WM, Poulton R. Trajectory patterns of dental caries experience to the fourth decade of life. Journal of Dental Research. 2008;87(1):69-72. Brookes RH, Hill PC, Owiafe PK, Ibanga HB, Jeffries DJ, Donkor SA, Fletcher HA, Hammond AS, Lienhardt C, Adegbola RA, McShane H, Hill AVS. Safety and immunogenicity of the candidate tuberculosis vaccine MVA85A in West Africa. PLoS ONE 2008; 3: e2921 (6pp) Caspi A, Langley K, Milne BJ, Moffitt TE, O’Donovan M, Owen MJ, et al. A replicated molecular genetic basis for subtyping antisocial behavior in children with Attention-Deficit/Hyperactivity Disorder. Archives of General Psychiatry. 2008;65(2):203-10. Clark DWJ, Ashton JA, Zhou L, Wallace AK, Kennedy MA (2008) Pharmacogenetic investigation using a pharmacovigilance database. PharmacoVigilance Review;2(3):9-13. Conlon N, O’Brien B, Herbison GP, Marsh B. Long-term functional outcome and performance status after intensive care unit re-admission: a prospective survey. Br J Anaesth. 2008 Feb;100(2):219-23. Conlon NP, Bale EP, Herbison GP, McCarroll M. Postoperative anemia and quality of life after primary hip arthroplasty in patients over 65 years old. Anesth Analg. 2008 Apr;106(4):1056-61.

204 RESEARCH REPORT 2007/2008 Connor J. The knock-on effects of unrestrained drinking. New Zealand Medical Journal 2008; 121(1271):2978. Cousins K, Kypri K. Alcohol advertsing in the new Zealand university student press. Drug & Alcohol Review, 2008 27, 566-569. Cox B. The effect of service screening on breast cancer mortality rates. Eur J Cancer Prev 2008; 17(4): 306-11. Crowe FL, Skeaff CM, McMahon JA, Williams SM, Green TJ. Lowering plasma homocysteine concentrations of older men and women with folate, vitamin B-12, and vitamin B-6 does not affect the proportion of (n-3) long chain polyunsaturated fatty acids in plasma phosphatidylcholine. J Nutr. 2008;138:551-5. Cryer C, Knox A, Stevenson E. Factors associated with hip protector adherence amongst older people in residential care. Injury Prevention, 2008: 14:24-29. Cryer C, Langley JD. Studies need to make explicit the theoretical and case definitions of injury. Injury Prevention, 2008: 14:74-77. Dachs GU, Currie MJ, McKenzie F, Jeffreys J, Cox B, Foliaki S, Le Marchand L, Robinson BA. Cancer disparities in indigenous Polynesian populations: Mäori, Native Hawaiians and Pacific people. Lancet Oncology 2008; 9: 473-484. Danese A, Moffitt TE, Pariante CM, Poulton R, Caspi A. Elevated inflammation levels in depressed adults with a history of childhood maltreatment. Archives of General Psychiatry. 2008;65(4):409-15. Davidson P, Chalmers D, Wilson B, McBride D. Lower limb injuries in New Zealand Defence Force personnel descriptive epidemiology. Australian NZ Journal of Public Health, 2008, 32:167-73 Davie G, Cryer C, Langley J. Improving the predictive ability of the ICD-based injury severity score (ICISS). Injury Prevention, 2008 14:250-255. Davie G, Langley J, Samaranayaka A, Wetherspoon M. Accuracy of injury coding under ICD-10-AM for New Zealand public hospital discharges. Injury Prevention, 2008, 14(5):319-23. Dean N, Wilson D, Herbison P, Glazener C, Aung T, Macarthur C. Sexual function, delivery mode history, pelvic floor muscle exercises and incontinence: a cross-sectional study six years post-partum. Aust N Z J Obstet Gynaecol. 2008 Jun;48(3):302-11. De Jong BC, Hill PC, Aiken A, Awine T, Antonio M, Adetifa IM, Jackson-Sillah DJ, Fox A, DeRiemer K, Borgdorff M, Gagneux S, McAdam KP, Corrah T, Small PM, Adegbola RA. Progression to tuberculosis, but not transmission, varies by M. tuberculosis lineage in The Gambia. J Infect Dis 2008; 198: 1037-43. Dennison J, Mahoney P, Herbison P, Dias G. The false and the true bifid condyles. Homo. 2008;59(2):149-59. Dickson N, van Roode T, Herbison GP, Paul C. Circumcision and risk of sexually transmitted infections in a birth cohort. Journal of Pediatrics. 2008;152(3):383-7. Dobbinson S, Wakefield M, Hill D, Girgis A, Aitken JF, Beckmann K, Reeder AI, Herd N, Fairthorne A, Bowles KA. Prevalence and determinants of Australian adolescents’ and adults’ weekend sun protection and sunburn, summer 2003-2004. Journal of the American Academy of Dermatology, 2008; 59(4): 602-614. Gauld, Robin, ‘The Unintended Consequences of New Zealand’s Primary Health Care Reforms’, Journal of Health Politics, Policy and Law, 33(1): 93-115, 2008. Gauld, Robin, ‘Local Accountability in the NHS’, British Medical Journal, 337: a1103, 2008. Godley R, Brown RC, Williams SM, Green TJ. Moderate alcohol consumption the night before glycaemic index testing has no effect on glycaemic response. Eur J Clin Nutr. 2008. Goulding A, Taylor RW, Grant AM, Murdoch L, Williams SM, Taylor BJ. Relationship of total body fat mass to bone area in New Zealand five-year-olds. Calcif Tissue Int. 2008;82:293-9. Grant AM, Taungapeau FK, McAuley KA, Taylor RW, Williams SM, Waldron MA, Duncan AW, Harper MJ, Goulding A. Body mass index status is effective in identifying metabolic syndrome components and insulin resistance in Pacific Island teenagers living in New Zealand. Metabolism. 2008;57:511-6. Gwynne Jones DP, Savage RL, Highton J (2008). Alendronate-induced synovitis. J Rheumatol;35(3);537-538. Hallet J, Maycock B, Kypri K et al. Development of a web-based alcohol intervention for university students: processes and challenges. Drug & Alcohol Review 28 (1) . Hammond AS, McConkey S, Hill PC, Gomez M, Crozier S, Klein MR, Adegbola RA, Rowland-Jones S, Brookes RH, Whittle H, Jaye A. Mycobacterium tuberculosis –specific immune responses are maintained across a broad range of CD4 T cell counts in patients coinfected with HIV. J Infect Dis 2008; 197:295-99. Hammond V, Reeder AI, Gray AR, Bell ML. Are workers or their workplaces the key to occupational sun protection? Health Promotion Journal of Australia, 2008; 19(2): 97-101. Hancox RJ, Welch D, Poulton R, Taylor A, McLachlan CR, Sears MR. Cigarette smoking and allergic sensitization: a 32-year population-based cohort study. Journal of Allergy and Clinical Immunology. 2008;121(1):38-42.e3. Hay-Smith J, Morkved S, Fairbrother KA, Herbison GP. Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women. Cochrane Database Syst Rev. 2008(4):CD007471. Heath AL, Roe MA, Oyston SL, Gray AR, Williams SM, Fairweather-Tait SJ. Blood loss is a stronger predictor of iron status in men than C282Y heterozygosity or diet. J Am Coll Nutr. 2008;27:158-67. Hewitt RS, Smith AD, Cowan JO, Schofield JC, Herbison GP, Taylor DR. Serial exhaled nitric oxide measurements in the assessment of laboratory animal allergy. J Asthma. 2008 Mar;45(2):101-7. Hill GR and Harrison-Woolrych ML (2008) Clozapine and myocarditis: a case series from the New Zealand Intensive Medicines Monitoring Programme. NZ Medical Journal Vol 121(1281): 68- 74. Hill PC, Cheung YB, Akisanya A, Sankareh K, Lahai G, Greenwood BM, Adegbola RA. Nasopharyngeal carriage of Streptococcus pneumoniae in Gambian infants – a longitudinal study. Clin Infect Dis 2008; 46:807-14. Hill PC, Jackson-Sillah DJ, Fox A, Brookes RH, de Jong BC, Jeffries DJ, Donkor SA, Lugos MD, Adetifa IM, Aiken AM, Howie SR, Corrah T, McAdam KP, Adegbola RA. Incidence of secondary disease and predictive value of initial ELISPOT and Mantoux tests in Gambian tuberculosis contacts. PLoS One 2008; 1:e1379 (7pp).

Division of HEALTH SCIENCES 205 Howard R, Karageorge G, van Harselaar K, Bell M, Basford P, Schultz M, Derrett S. Post-procedure surveillance in liver biopsy: how long is long enough? New Zealand Medical Journal Vol:121 (1280) 22 August 2008. Howie SR, Hill SE, Peel D, Njie M, Hill PC, Weber M, Mulholland K, Adegbola RA. Beyond good intentions: lessons on equipment donation from an African hospital. Bull WHO 2008; 86: 52-56. Jenks KA, Stamp LK, O’Donnell JL, Savage RL, Chapman PT (2008) Leflunomide-associated infections in rheumatoid arthritis. J Rheumatol;34(11):2201-2203. Jopson JA, Reeder AI. An audit of Yellow Pages telephone directory listings of indoor tanning facilities in New Zealand, 1992- 2006. Australian and New Zealand Journal of Public Health, 2008; 32(4): 372-376. Kerruish NJ, Webster D, Dickson N. Information and consent for newborn screening in New Zealand: practices and attitudes of service providers. Journal of Medical Ethics 2008;34;648-52 Koenen K, Moffitt TE, Caspi A, Gregory AM, Harrington HL, Poulton R. The developmental mental disorder histories of adults with PTSD: a prospective longitudinal birth cohort study. Journal of Abnormal Psychology. 2008;117(2):460-6. Kunac DL, Harrison-Woolrych ML and Tatley MV (2008) Pharmacovigilance in New Zealand: The role of the New Zealand Pharmacovigilance Centre in facilitating safer medicines use. NZ Medical Journal 121(1281): 76-89 Kunac DL, Reith DM (2008) Preventable medication-related events in hospitalised children in New Zealand. N Z Med J;121(1272):17-32 Kypri K, Langley JD, Saunders JB, Cashell-Smith ML, Herbison P. Randomized controlled trial of web-based alcohol screening and brief intervention in primary care. Arch Intern Med. 2008 Mar 10;168(5):530-6. Kypri K, Bell ML, Hay GC, Baxter J (2008) Alcohol outlet density and university student drinking: a national study. Addiction. 2008 Jul;103(7):1131-8. Landhuis CE, Poulton R, Welch D, Hancox RJ. Programming obesity and poor fitness: the long-term impact of childhood television viewing. Short Communication. Obesity. 2008 2008;16(6):1457-9. Landhuis CE, Poulton R, Welch D, Hancox RJ. Childhood sleep-time and long-term risk for obesity: a 32-year prospective birth cohort study. Pediatrics. 2008;122:955-60. Langley J, Cryer C, Davie G. NZ Government’s trend analysis of hospitalised self-harm is misleading. Australian NZ Journal of Public Health, 2008 32:162-6 . Langley J, Kypri K, Cryer C, Davie G. Assessing the validity of potential alcohol-related non-fatal injury indicators. Addiction, 2008, 103:397-404. Lauti M, Herbison P, Hay-Smith J, Ellis G, Wilson D. Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Nov;19(11):1533-43. Lawrence HP, Thomson WM, Broadbent JM, Poulton R. Oral-health-related quality of life in a cohort of 32-year-olds. Community Dentistry and Oral Epidemiology. 2008;36(4):305-16. Lim Y, Quick A, Swain M, Herbison P. Temperature Effects on the Forces, Moments and Moment to Force Ratio of Nickel- Titanium and TMA Symmetrical T-loops. Angle Orthod. 2008 Nov;78(6):1035-42. Manning PJ, Sutherland WH, Walker RJ, Williams SM, de Jong SA, Berry EA. The effect of rosiglitazone on oxidative stress and insulin resistance in overweight individuals. Diabetes Res Clin Pract. 2008, 81(2):209-15. McCredie MRE, Sharples KJ, Paul C, Baranyai J, Medley G, Jones RW, Skegg DCG. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neophasia 3: A retrospective cohort study. Lancet Oncology 2008; 9: 425-434. McAllister S, Dickson N, Sharples K, Coughlan E, McDonald J, Morgan J, Reid M, Johnston T, Tanner N, Paul C. Unlinked anonymous HIV prevalence among New Zealand sexual health clinic attenders 2005/06. International Journal of STD and AIDS 2008;19:752-7 Meyboom RHB, Star K, Bate J, Savage R, Edwards IR (2008) TNF-alpha inhibitors and leukaemia: International pharmacovigilance reports. Drug Safety;31(5):445-447 Miller D, Livingstone V, Herbison P. Interventions for relieving the pain and discomfort of screening mammography. Cochrane Database Syst Rev. 2008(1):CD002942. Milne, B. J., Moffitt, T. E., Crump, R., Poulton, R., Rutter, M., Sears, M. R., Taylor, A., and Caspi, A. (2008) How should we construct psychiatric family history scores? A comparison of alternative approaches from the Dunedin Family Health History Study. Psychological Medicine, 38(12), 1793-802. Moore KN, Valiquette L, Chetner MP, Byrniak S, Herbison GP. Return to Continence After Radical Retropubic Prostatectomy: A Randomized Trial of Verbal and Written Instructions Versus Therapist-Directed Pelvic Floor Muscle Therapy. Urology. 2008 Apr 1. O’Brien KS, Kypri K. Alcohol industry sponsorship and hazardous drinking among sportspeople. Addiction, 103,1961-1966. Odgers CL, Caspi A, Nagin DS, Piquero AR, Slutske W, Milne BJ, et al. Is it important to prevent early exposure to drugs and alcohol among adolescents? Psychological Science. 2008;19(10):1037-44. Odgers CL, Caspi A, Poulton R, Harrington HL, Thomson WM, Broadbent JM, et al. Female and male antisocial trajectories: From childhood origins to adult outcomes. Development and Psychopathology. 2008;20(2):673-716. Odgers CL, Moffitt TE, Broadbent JM, Dickson N, Hancox RJ, Harrington H, Poulton R., Sears MR, Thompson WM, Caspi A. Female and male antisocial trajectories: From childhood origins to adult outcomes. Development and Psychopathology 2008;20: 673-71. Owen CG, Whincup PH, Kaye SJ, Martin RM, Davey Smith G, Cook DG, et al. Does initial breastfeeding lead to lower blood cholesterol in adult life? A quantitative review of the evidence. American Journal of Clinical Nutrition. 2008;88(2):305-14.

206 RESEARCH REPORT 2007/2008 Palmer SE, McLean RM, Ellis PM and Harrison-Woolrych ML (2008). Life-threatening clozapine-induced gastro-intestinal hypomotility: an analysis of 102 cases. Journal of Clinical Psychiatry published 29 April 2008 ahead of print. Paul C. Commentary: hormone therapy and breast cancer incidence: did epidemiologists miss an effect on national trends? Int J Epidemiol 2008;37: 638-40. Paul C, Nicholls R, Priest P, McGee R. Making policy decisions about population screening for breast cancer: The role of citizens’ deliberation. Health Policy, 2008; 85(3): 314-320. Paul C, van Roode T, Herbison P, Dickson N. Longitudinal Study of Self-Reported Sexually Transmitted Incidence by Gender and Age up to Age Thirty-Two Years. Sex Transm Dis. 2008 Sep 10. Poulton R, Andrews G, Millichamp J. Gene-environment interaction and the anxiety disorders. Special Issue - Editorial. European Archives of Psychiatry and Clinical Neuroscience. 2008;258(2):65-8. Quigg, R and Freeman, C. (2008) Do children like walking? Children in the city of Dunedin, New Zealand. Children Australia. 33(3): 13-20 Richardson A, Fletcher L, Sneyd MJ, Cox B, Reeder AI. The incidence and thickness of cutaneous malignant melanoma in New Zealand 1994–2004. New Zealand Medical Journal, 2008; 121(1279). Robertson SP, Poulton R. Longitudinal studies to detect gene x environment interactions in common disease - Bang for your buck? A commentary on Chaufan’s “How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people?”. Social Science and Medicine. 2008;67(4):666-72. Rockell JE, Skeaff CM, Williams SM, Green TJ. Association between quantitative measures of skin color and plasma 25-hydroxyvitamin D. Osteoporos Int. 2008; 19(11):1639-42. Rutherford ME, Dockerty JD, Jasseh M, Howie SR, Herbison P, Jeffries DJ, Leach M, Stevens W, Mulholland K, Adegbola RA, Hill PC. Access to healthcare and under 5 mortality in West Africa: a case control study. Bull WHO, 3(1):e1522. Savage R. Tumour necrosis factor inhibitors – recognise and treat infection promptly. Prescriber Update 2008;29(1):5-6 Savage R. Leflunomide- update on serious toxicity. Prescriber Update 2008;29(1):13-14 Savage R, Tatley M. CARM reports and safer prescribing. NZ Doctor 27 February 2008, p23 Scragg R, Reeder AI, Wong G, Glover M, Nosa V. Attachment to parents, parental tobacco smoking and smoking among Year 10 students in the 2005 New Zealand national survey. Australian and New Zealand Journal of Public Health, 2008; 32(4): 348-353. Sneyd, M.J (2008). Ethnic differences in prostate cancer survival in New Zealand: a national study. Cancer Causes and Control, 19 (9): 993-9. Sneyd MJ, Cox B, Reeder AI, Richardson, A. European melanoma incidence: a response to Professor Shaw’s melanoma editorial. New Zealand Medical Journal, 2008; 121(1285): 141-142. Stevens W, Stevens G, Kolbe J, Cox B. Delays in the management of lung cancer in New Zealand, Asia Pacific J Clin Oncol, 2008, 4(2): 98-106. Stevens W, Stevens G, Kolbe J, Cox B. Ethnic differences in the management of lung cancer in New Zealand. Journal of Thoracic Oncology 2008; 3: 237-244. Sutherland TJ, Cowan JO, Young S, Goulding A, Grant AM, Williamson A, et al. The association between obesity and asthma: interactions between systemic and airway inflammation. Am J Respir Crit Care Med. 2008 Sep 1;178(5):469-75. Sutherland TJ, Goulding A, Grant AM, Cowan JO, Williamson A, Williams SM, Skinner MA, Taylor DR. The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function. Eur Respir J. 2008;32:85-91. Tatley MV, Kunac DL, McNicholas A, Zhou L, Ballantyne S, Ashton J, Stehr-Green P, Galloway Y, Reid S (2008) The Intensive Vaccines Monitoring Programme (IVMP): An electronic system to monitor vaccine safety in New Zealand. Vaccine; 26(22):2746-52 Taylor RW, Williams SM, Grant AM, Ferguson E, Taylor BJ, Goulding A. Waist circumference as a measure of trunk fat mass in children aged 3 to 5 years. Int J Pediatr Obes. 2008:1-8. Te Moananui R, Kieser JA, Herbison GP, Liversidge HM. Estimating age in Mäori, Pacific Island, and European children from New Zealand. J Forensic Sci. 2008 Mar;53(2):401-4. Te Moananui R, Kieser JA, Herbison P, Liversidge HM. Advanced dental maturation in New Zealand Mäori and Pacific Island children. Am J Hum Biol. 2008 Jan-Feb;20(1):43-50. Thomson WM, Poulton R, Broadbent JM, Moffitt TE, Caspi A, Beck JD, et al. Cannabis smoking and periodontal disease among young adults. JAMA. 2008;299(5):525-31. Thornley S, Woodward A, Langley J, Ameratnga S, Rodgers A. Conspicuity and bicycle crashes: preliminary findings of the Taupo Bicycle Study. Injury Prevention 2008,14:11-18. Van Os J, Rutten BPF, Poulton R. Gene-environment interactions: A review of epidemiological findings and future directions. Schizophrenia Bulletin. 2008;34(6):1066-82. Waldie KE, McGee R, Reeder A, Poulton R. Association between frequent headaches, persistent smoking and attempts to quit. Headache. 2008;48(4):545-52. Wassie L, Demissie A, Aseffa A, Abebe M, Yamuah L, Tilahun H, Petros B, Rook G, Zumla A, Andersen P, Doherty TM; VACSEL Study Group. Ex vivo cytokine mRNA levels correlate with changing clinical status of ethiopian TB patients and their contacts over time. PLoS ONE. 2008 Jan 30;3(1):e1522. Waters DL., Qualls CR., Dorin RI., Veldhuis JD., Baumgartner RN,. Altered Growth Hormone, Cortisol, and Leptin Secretion in Healthy Elderly with Sarcopenia and Mixed Body Composition Phenotypes. Journals of Gerontology: Medical Sciences. 2008; 63(5) 536-541.

Division of HEALTH SCIENCES 207 Welch D, Dawes PJ. Personality and perception of tinnitus. Ear and Hearing. 2008;29(5):684-92. Williams SM, Venn BJ, Perry T, Brown R, Wallace A, Mann JI, Green TJ. Another approach to estimating the reliability of glycaemic index. Br J Nutr. 2008:1-9. Wong CK, Herbison P, Tang EW. Relation between blood pressure at hospital discharge after an acute coronary syndrome and long-term survival. Am J Cardiol. 2008 May 1;101(9):1239-41. Wong CK, Tang EW, Herbison P. The use of different evidence-based medications and 5-year survival after an acute coronary syndrome: An observational study. Int J Cardiol. 2008 Jan 10. Wong CK, Tang EW, Herbison P, Birmingham B, Barclay L, Fu SY. Pre-existent depression in the 2 weeks before an acute coronary syndrome can be associated with delayed presentation of the heart attack. Qjm. 2008 Feb;101(2):137-44. Wright C, Reeder A, Gray A, Cox B. Child sun protection: Sun-related attitudes mediate the association between children’s knowledge and behaviours. Journal of Paediatrics and Child Health, 2008; 44(12): 692-698. Yelavich S, Towns C, Burt R, Chow K, Donohue R, Sani HSH, Taylor K, Gray A, Eberhart-Phillips J, Reeder AI. Walking to school: frequency and predictors among primary school children in Dunedin, New Zealand. New Zealand Medical Journal, 2008; 121: 1271. Zacharias M, Conlon NP, Herbison GP, Sivalingam P, Walker RJ, Hovhannisyan K. Interventions for protecting renal function in the perioperative period. Cochrane Database Syst Rev. 2008(4):CD003590.

Report Australian Cancer Network Melanoma Guidelines Revision Working Party. Clinical Practice Guidelines for the Management of Melanoma in Australia and New Zealand. The Cancer Council Australia and Australian Cancer Network, Sydney and New Zealand Guidelines Group, Wellington. Nov 2008. Baxter, J. (2008) Mäori Mental Health Needs Profile – A review of the evidence. Palmerston North: Ministry of Health and Te Rau Matatini. Cousins, K., Wilson, J., Kypri, K., Baxter, J. (2008) Alcohol-related harm among New Zealand university students: Institutional policies, liquor law enforcement, and health care 75pp. Injury Prevention Research Unit. April 2008. Cryer C, Gulliver P, Russell, Davie G, Langley J. (2008). The development of impairment-related injury outcome indicators. Report to ACC. Cryer C, Langley J. (2008). Developing indicators of injury incidence that can be used to monitor global, regional and local trends. Injury Prevention Research Unit, University of Otago. Commissioned by the Department of Violence & Injury Prevention & Disability (VIP), WHO. Hay G, Kypri K, Whigham P, Langley J. (2008). Potential biases due to geocoding error in spatial analyses of official data. Health and Place, doi:10.1016/jhealthplace.2008.09.002. International Agency for Research on Cancer. (2008). IARC Working Group Reports. Volume 5. Vitamin D and Human Cancer. Richards R. Neighbourhood and physical activity: a scoping study. A technical report to the National Centre for Lifecourse Research, Dunedin Multidisciplinary Health and Development Research Unit, Department of Preventive & Social Medicine, Dunedin, 31 March 2008 (7p). Richards R, Darling H. (2008). Interest in sports among inactive adolescents: an opportunity for public health. Technical report prepared for the Health Sponsorship Council and the Cancer Society of New Zealand. (11p).

Journal – Research Other Darling H, Richards R. Kids on Bikes: A community intervention. Preventive Medicine 2008; 46(1):82.

Journal – Professional and Non Research Article Egan R. Death: A Reflection. Commentary. New Zealand Family Physician, 2008; 35(5): 338. Egan, R. Spirituality and Health Promoting Schools, in Health Promoting Schools Magazine. April 2008. Hammond V. Outdoor workers- How can employers keep staff safe? Health & Safety Magazine, Nov/Dec, 2008 Gauld, R. (2008). Book review of ‘Medicine and the Market: Equity v. Choice’, by Daniel Callahan and Angela A. Wasunna, History and Health, 10(2).

Submission Cryer C, Submission to Social Conditions Business Unit, Statistics New Zealand - Review of the Official Injury Statistics Programme Feedback Report, Draft 160408. Kypri K, Langley J. Submission to Social Services Committee – Sale of Liquor (Objections to Applications) Amendment Bill. MacLennan B, Kypri K. Submission to Social Services Committee – Sale of Liquor (Objections to Applications) Amendment Bill. 14 August 2008. Reeder AI. Submission to Joints Standards Australia/Standards New Zealand Committee CS-064 on revision of Solaria for cosmetic purpose:AS/NZS 2635:2002. August 6, 2008.

208 RESEARCH REPORT 2007/2008 DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Chapter in Book Davidson, O.R. (2008). Psychological and mental health issues. In: Adler, Williams & Miller (Eds). ABC of AIDS (6th Edition). BMJ Books. Blackwell: Oxford.

Journal – Research Article Andrews E, Damle BD, Fang A, Foster G, Crownover P, LaBadie R, Glue P. Pharmacokinetics and tolerability of voriconazole and a combination oral contraceptive coadministered in healthy female subjects. Br J Clin Pharmacol 2008, 65:531-539. Damle B, Labadie R, Crownover P, Glue P. Pharmacokinetic interactions of efavirenz and voriconazole in healthy volunteers. Br J Clin Pharmacol 2008, 65:523-530. El-Tahtawy A, Glue P, Andrews EN, Mardekian J, Amsden G, Knirsch C. The effect of azithromycin on ivermectin pharmacokinetics – a population pharmacokinetic model analysis. PLoS-Neglected Tropical Diseases 2008, 2:e236. Fang, AF, Damle BD, LaBadie R, Crownover PH, Hewlett D, Glue P. Significant decrease in nelfinavir systemic exposure after omeprazole coadministration in healthy subjects. Pharmacother 2008, 28:42-50 Gale C, and Davidson O. Tired and Anxious. BMJ. 2008 Oct 1; 337: a 1241. Gandelman K, Alderman J, Glue P, Lombardo I, Labadie RR, Versavel M, Preskorn S. The impact of calories and fat content of meals on oral ziprasidone absorption: a randomized, open label, crossover trial. J Clin Psychiatry 2008, Oct 21. Epub ahead of print. Garcia J, Mullen R (2008). Follow up of post-traumatic stress disorder symptoms in Australian servicemen hospitalized in 1942-1952 (letter). Australian and New Zealand Journal of Psychiatry, 42, 6, 547. Malhotra BK, Glue P. Response to “Feedback to Tolterodine QT”. Clin Pharmacol Ther 2008, 83:233. Mullen R, Admiraal A, Trevena T (2008) Defensive practice in mental health. New Zealand Medical Journal, 121: 85-91. Mullen R, Menkes DB (2008) Psychiatriform disorder: psychiatric analogues of somatoform disorders. International Journal of Social Psychiatry. 54 (5) 395-401. Poulton R, Andrews G & Millichamp J (2008). Gene-environment interaction and the anxiety disorders. European Archives of Psychiatry and Clinical Neuroscience, 258 (2), 65-8. Winburn E, Mullen R (2008) Personality disorder and competence to refuse treatment. Journal of Medical Ethics, 34, 715-716.

Online Resource Gale C and Millichamp J. Generalized Anxiety Disorder. Physicians Information and Educational Resource (PIER) American College of Physicians. http://pier.acponline.org/physicians/diseases/d086/d086.html. 2008.

DUNEDIN SCHOOL OF MEDICINE DEPARTMENT OF WOMEN’S AND CHILDREN’S HEALTH

Obstetrics and Gynaecology

Journal – Research Article Dean N, Wilson D, Herbison P, Glazener C, Aung T, Macarthur C. Sexual function, delivery mode history, pelvic floor muscle exercises and incontinence: a cross-sectional study six years post-partum. Aust N Z J Obstet Gynaecol 2008;48(3):302-11. Grace VM, Daniels KR, Gillett W. The donor, the father, and the imaginary constitution of the family: parents’ constructions in the case of donor insemination. Soc Sci Med 2008;66(2):301-14. Lauti M, Herbison P, Hay-Smith J, Ellis G, Wilson D. Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial. Int Urogynecol J Pelvic Floor Dysfunct 2008, 19(11):1533-43. Lauti M, & Miller, D. L. Midwives’ and obstetricians’ perception of their role in the indentification and management of family violence. New Zealand College of Midwives 2008; 38 (April). Miller D, Roberts H, Wilson D. Future practice of graduates of the New Zealand Diploma of Obstetrics and Gynaecology or Certificate in Women’s Health. NZ Med J 2008;121(1282):29-38. Miller D, Livingstone V, Herbison P. Interventions for relieving the pain and discomfort of screening mammography. Cochrane Database Syst Rev 2008(1):CD002942. Miller D. Assessment and management of miscarriage. New Zealand Family Practice 2008, (35(3)):202-206.

Division of HEALTH SCIENCES 209 Paediatrics and Child Health

Journal – Research Article Bicknell LS, Pitt J, Aftimos S, Ramadas R, Maw MA, Robertson SP. A missense mutation in ALDH18A1, encoding Delta(1)- pyrroline-5-carboxylate synthase (P5CS), causes an autosomal recessive neurocutaneous syndrome. Eur J Hum Genet 2008, 16(10):1176-86. Clarkson JE, Maslin JP. Working Toward a Family Centred Service for Children with Developmental Disabilities New Zealand Journal of Disability Studies 2008(13):46-52. Gabbett MT, Robertson SP, Broadbent R, Aftimos S, Sachdev R, Nezarati MM. Characterizing the oculoauriculofrontonasal syndrome. Clin Dysmorphol 2008;17(2):79-85. Galland BC, Jackson PM, Sayers RM, Taylor BJ. A Matched Case Control Study of Orthostatic Intolerance in Children/ Adolescents With Chronic Fatigue Syndrome. Pediatr Res 2008;63(2):196-202. Goulding A, Taylor RW, Grant AM, Murdoch L, Williams SM, Taylor BJ. Relationship of Total Body Fat Mass to Bone Area in New Zealand Five-Year-Olds. Calcif Tissue Int 2008, 82(4):293-9. Jenkins ZA, van Kogelenberg M, Morgan T, Jeffs A, Fukuzawa R, Pearl E, Thaller C, Hing AV, Porteous ME, Garcia-Miñaur S, Bohring A, Lacombe D, Stewart F, Fiskerstrand T, Bindoff L, Berland S, Adès LC, Tchan M, David A, Wilson LC, Hennekam RC, Donnai D, Mansour S, Cormier-Daire V, Robertson SP. Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis. Nature Genetics Epub 2008 Dec 14. Kunac DL, Reith DM. Preventable medication-related events in hospitalised children in New Zealand. N Z Med J 2008;121(1272):17-32. Millar T, Sandilya R, Tordoff J, Ferguson R. Documenting pharmacists’ clinical interventions in New Zealand hospitals. Pharm World Sci. 2008, 30(1):99-106. Reith D, Medlicott NJ, Kumara De Silva R, Yang L, Hickling J, Zacharias M. Simultaneous Modelling of the Michaelis-Menten Kinetics of Paracetamol Sulphation and Glucuronidation. Clin Exp Pharmacol Physiol 2008, Aug 26. Epub ahead of print. Robertson S, Poulton R. Longitudinal studies to detect genexenvironment interactions in common disease – Bang for your buck? A commentary on Chaufan’s “How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people? Soc Sci Med 2008;67(4):666-72. Sherwin CM, Svahn S, Broadbent RS, Van Der Linden A, Medlicott NJ, Reith DM. Netilmicin withdrawal: impact on neonates. N Z Med J 2008;121(1284):95-7. Sherwin CM, Broadbent RS, Medlicott NJ, Reith DM. Individualising netilmicin dosing in neonates. Eur J Clin Pharmacol 2008, 64(12):1201-8. Sherwin C, Broadbent R, Young S, Worth J, McCaffrey F, Medlicott NJ, Reith D. Utility of Interleukin-12 and Interleukin-10 in Comparison with Other Cytokines and Acute-Phase Reactants in the Diagnosis of Neonatal Sepsis. Am J Perinatol 2008, 25(10):629-36. Tordoff JM, Norris PT, Reith DM. “Price Management” and Its Impact on Hospital Pharmaceutical Expenditure and the Availability of Medicines in New Zealand Hospitals. Value Health 2008, May 15. Epub ahead of print. van Roij MH, Mizumoto S, Yamada S, Morgan T, Tan-Sindhunata MB, Meijers-Heijboer H, Verbeke JI, Markie D, Sugahara K, Robertson SP. Spondyloepiphyseal dysplasia, Omani type: further definition of the phenotype. Am J Med Genet A 2008;146A(18):2376-84.

Report Child and Youth Mortality Review Committee (CYMRC): Fourth Report to the Minister of Health: Reporting mortality 2002- 2005. Wellington: Minstry of Health 2008:58. New Zealand Paediatric Surveillance Unit (NZPSU): Annual Report 2007: 10th Anniversary Report. In: Medicine DSo, editor. Dunedin: University of Otago, 2008:27.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF ANAESTHESIA

Journal – Research Article Kennedy RR, French R. Changing patterns in anesthetic fresh gas flow rates over 5 years in a teaching hospital. Anesth Analg 2008;106(5):1487-90. Kennedy RR, Minto C, Seethepalli A. Effect-site half-time for burst suppression is longer than for hypnosis during anaesthesia with sevoflurane. Br J Anaesth 2008 ;100(1):72-7. Shipton EA. Pain Assessment in Dementia. NZ Med J 2008: 121(1286):9-11. Shipton EA. The chronic pain experience – a dynamic complex interaction. NZ Med J 2008;121:1270. Shipton EA. Post-surgical neuropathic pain. ANZ J Surg 2008;78:548-555. Shipton EA, Lin A. Anaesthesia and Analgesia: contribution to surgery – present and future. ANZ J Surg 2008; 78:540-547.

210 RESEARCH REPORT 2007/2008 UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF MEDICINE

Book – Textbook or other Gommans J, Barber PA, Fink J. New Zealand guideline for the assessment and management of people with recent transient ischaemic attack (TIA). Stroke Foundation of New Zealand Inc. Wellington 2008.

Chapter in Book Endre ZH, Edelstein CL. Animal models for the assessment of acute renal dysfunction and injury. In “Clinical nephrotoxins: renal injury from drugs and chemicals.” (eds. M.E De Broe, G.A. Porter, W.M. Bennett and G.A. Verpooten). 3rd edition. 2008, pp 181 – 232 in press Kluwer, Amsterdam. Keeling,S. and Davey, J.(2008) Working carers in New Zealand: Zones of Care and Contested Boundaries, in Martin-Matthews A and Phillips J.(eds), Aging and Caring at the Intersection of Work and Home Life: Blurring the boundaries. Lawrence Erlbaum Associates/Taylor and Francis Group, NY/London. 129-146. Nicholls MG, Petroianu G, Carruthers GA. Angiotensin converting enzyme inhibitors. In: Handbook of Hypertension. Eds: Birkenhager WH, Reid JL. Elsevier, 2008. Nicholls MG, Richards AM. (2008). High-risk subgroups: Diabetes and hypertension (Ch16) In: NTproBNP as a Biomarker in Cardiovascular Diseases Eds. A Bayes-Genis, J Januzzi, Prous Science. Stamp LK and Cleland LG. Foods and Rheumatological Diseases. In: Food Allergy Adverse Reactions to Foods and Food Additives 2008. (Editor Metcalfe, Sampson and Simon) Fourth Edition. Stamp LK and Cleland LG. Rheumatoid Arthritis. In: Optimising Women’s Health through Nutrition 2008. (Editors Thompson and Ward) First Edition. Stamp LK Gout. In: Diseases and Disorders 2008. (Editors Goddard and Hilyard). Troughton RW, Richards AM. (2008). Outpatient monitoring and treatment (Ch10). In: NTproBNP as a Biomarker in Cardiovascular Diseases Eds. A Bayes-Genis, J Januzzi, Prous Science. Troughton RW, Richards AM. (2008). Natriuretic Peptides for disease monitoring in patients with chronic heart failure. In: Biomarkers in Heart Disease Eds. De Lemos J, Antman E. American Heart Association; Blackwell US. pp. 138-156. Troughton RW, Ritzema-Carter J, Nicholls MG. Role of Neurohormones. In: Diastology. Eds: Klein AL, Garcia MJ. Saunders/ Elsevier, 2008, pp345-366. Walker, RJ, Endre, ZH. Cellular mechanisms of drug nephrotoxicity. In: Seldin & Giebisch’s The Kidney, Physiology and Pathophysiology, Fourth Edition, ed. RJ Alpern and SC Hebert. 2008. pp 2507-2535. San Diego: Academic Press.

Journal – Research Article Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and cancer of the head and neck: case-control study. Otolaryngol Head Neck Surg. 2008 Mar;138(3):374-80. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and risk of lung cancer: a case-control study. Eur Respir J. 2008 Feb;31(2):280-6 Amadeus Investigators, Bousser MG, Bouthier J, Büller HR, Cohen AT, Crijns H, Davidson BL, Halperin J, Hankey G, Levy S, Pengo V, Prandoni P, Prins MH, Tomkowski W, Torp-Pedersen C, Wyse DG. Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non- inferiority trial. Lancet. 2008 Jan 26;371(9609):315-21. Attoub S, Gaben AM, Al-Salam S, Al Sultan MAH, John A, Nicholls MG, Mester J, Petroianu G. Captopril as a potential inhibitor of lung tumor growth and metastasis. Ann N Y Acad Sci 2008;1138:65-72. Baggish AL, Lloyd-Jones DM, Blatt J, Richards AM, Lainchbury J, O’Donoghue M, Sakhuja R, Chen AA, Januzzi JL. A clinical and biochemical score for mortality prediction in patients with acute dyspnoea: derivation, validation and incorporation into a bedside programme. Heart 2008; 94(8): 1032-1037. Barrett JS, Canale KE, Gearry RB, Irving PM, Gibson PR. Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome. World J Gastroenterol. 2008 Aug 28;14(32):5020-4. Begg EJ. Prescribing in pregnancy and lactation. Br J Clin Pharmacol 2008 65:5:627-8 Bentley RW, Keenan JI, Gearry RB, Kennedy MA, Barclay ML, Roberts RL. Incidence of Mycobacterium avium Subspecies paratuberculosis in a Population-Based Cohort of Patients With Crohn’s Disease and Control Subjects. Am J Gastroenterol 2008 103(5):1168-72. Browning BL, Annese V, Barclay ML, Bingham SA, Brand S, Büning C, Castro M, Cucchiara S, Dallapiccola B, Drummond H, Ferguson LR, Ferraris A, Fisher SA, Gearry RB, Glas J, Henckaerts L, Huebner C, Knafelz D, Lakatos L, Lakatos PL, Latiano A, Liu X, Mathew C, Müller-Myhsok B, Newman WG, Nimmo ER, Noble CL, Palmieri O, Parkes M, Petermann I, Rutgeerts P, Satsangi J, Shelling AN, Siminovitch KA, Török HP, Tremelling M, Vermeire S, Valvano MR, Witt H. Gender- stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet 2008 Jan;45(1):36-42. Butler JM and Begg EJ. Free Drug Metabolic Clearance in Elderly People. Clinical Pharmacokinetics 2008;47(5):297-321. Charles CJ, Jardine DL, Nicholls MG, Rademaker MT, Richards AM. Urocortin 1 exhibits potent inhibition of cardiac sympathetic nerve activity in conscious sheep. J Hypertens 2008; 26:53-60

Division of HEALTH SCIENCES 211 Charles CJ, Katafuchi T, Yandle TG, Minamino N. Identification and biological activity of ovine and caprine calcitonin receptor-stimulating peptides 1 and 2. J Endocrinol. 2008 Aug;198(2):429-37. Dalrymple J, Stamp LK, O’Donnell JL, Chapman PT, Zhang M, Barclay ML. Pharmacokinetics of Oral Methotrexate in Patients with Rheumatoid Arthritis. Arthritis and Rheumatism 2008;58(11); 3299-3308 Davis SM, Donnan GA, Parsons MW, Levi C, Butcher KS, Peeters A, Barber PA, Bladin C, De Silva DA, Byrnes G, Chalk JB, Fink JN, Kimber TE, Schultz D, Hand PJ, Frayne J, Hankey G, Muir K, Gerraty R, Tress BM, Desmond PM; EPITHET investigators. Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol. 2008 Apr;7(4):299-309. Dawson SI, Willis J, Florkowski CM, Scott RS. Cause-specific mortality in insulin-treated diabetic patients: a 20-year follow- up. Diabetes Res Clin Pract. 2008 Apr;80(1):16-23. Dawson SI, Willis J, Florkowski CM, Scott RS. All-cause mortality in insulin-treated diabetic patients: a 20-year follow-up. Diabetes Res Clin Pract. 2008 Apr;80(1):e6-9. Epub 2008 Mar 7. Dixon B, Darlow B, Prickett T. How useful is knemometry in measuring neonatal growth? J Paediatr Child Health. 2008 Jul- Aug;44(7-8):444-8. Duncan E, Beckert L. Medical image. Lung metastases in adenocarcinoma. N Z Med J. 2008 Dec 12;121(1287):85. Ellis MJ, Livesy JH, Soule SG. Prolactin immunoreactivity in Rheumatoid factor-containing specimens:is it prolactin, macroprolactin or assay interference? Open Clin Chem J 2008:1;38-41. Ellmers, L.J., N.J.A. Scott, S. Medicherla, A.P. Pilbrow, P.G. Bridgman, A.M. Richards, A.A. Protter, V.A. Cameron. (2008). TGF- beta blockade down-regulates the renin-angiotensin system and indices of cardiac remodeling post-myocardial infarction. Endocrinology 149:5828-5834. Elmslie JL, Porter RJ, Joyce PR, Hunt PJ, Shand BI, Scott RS. Comparison of insulin resistance, metabolic syndrome and adiponectin in overweight bipolar patients taking sodium valproate and controls. Aust N Z J Psychiatry. 2009 Jan;43(1):53-60. Endre ZH. Acute Kidney Injury: Definitions and New Paradigms. Advances in Chronic Kidney Disease. 2008, 15 (3) pp. 213-21. Endre ZH, Westhuyzen. Early detection of acute kidney injury (AKI): emerging new biomarkers. Nephrology 2008 Mar;13(2): 91-98. Epton MJ, Dawson RD, Brooks WM, Kingham S, Aberkane T, Cavanagh JA, Frampton CM, Hewitt T, Cook JM, McLeod S, McCartin F, Trought K, Brown L. The effect of ambient air pollution on respiratory health of school children: a panel study. Environ Health. 2008 May 14;7:16 Ferguson LR, Browning BL, Huebner C, Petermann I, Shelling AN, Demmers P, McCulloch A, Gearry RB, Barclay ML, Philpott M. Single nucleotide polymorphisms in human Paneth cell defensin A5 may confer susceptibility to inflammatory bowel disease in a New Zealand Caucasian population. Dig Liver Dis 2008 14(29):4652-61. Ferguson LR, Huebner C, Petermann I, Gearry RB, Barclay ML, Demmers P, McCulloch A, Han DY. Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. World J Gastroenterol. 2008 Aug 7;14(29):4652-61. Fink JN, Frampton CM, Lyden P, Lees KR; Virtual International Stroke Trials Archive Investigators. Does hemispheric lateralization influence functional and cardiovascular outcomes after stroke?: an analysis of placebo-treated patients from prospective acute stroke trials. Stroke. 2008 Dec;39(12):3335-40 Gardiner SJ, Kirkpatrick CMJ, Zhang M, Begg EJ. Cimetidine does not appear to influence the distribution of metformin into human milk. Br J Clin Pharmacol 2008 66(4):564-5. Gardiner SJ, Gearry RB, Begg EJ, Zhang M, Barclay ML. Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold. Clin Gastroenterol Hepatol. 2008 Jun;6(6):654-60. Gardiner SJ, Gearry RB, Burt MJ, Ding SL, Barclay ML. Severe hepatotoxicity with high 6-methylmercaptopurine nucleotide concentrations after thiopurine dose escalation due to low 6-thioguanine nucleotides. Eur J Gastroenterol Hepatol. 2008 Dec;20(12):1238-42. Gearry RB, Day AS. Inflammatory bowel disease in New Zealand children: a growing problem. NZ Med J. 2008 Oct 3;121(1283):5-8. Gommans J, Barber PA, Hanger HC and Bennett P. Rehabilitation after Stroke: changes between 2002 and 2007 in services provided by District Health Boards in New Zealand. NZ Med J 2008;121:1274. Gurnell EM, Hunt PJ, Curran SE, Conway CL, Pullenayegum EM, Huppert FA, Compston JE, Herbert J, Chatterjee VK. Long- term DHEA replacement in primary adrenal insufficiency: a randomized, controlled trial. J Clin Endocrinol Metab. 2008 Feb;93(2):400-9. Hambleton, P., Keeling, S. and McKenzie M. (2008) Quality of life is…: The Views of Older Recipients of Low Level Home Support Social Policy Journal of New Zealand Vol.33: 146-162. Hanger HC, Fletcher V, Brown AJ, Wilkinson TJ, Frampton CM, Sainsbury R. Effect of Aspirin and Warfarin on Early Survival after Intracerebral Haemorrhage. J Neurology 2008;255(3):347-352. Heppenstall CP, Hanger HC, Wilkinson TJ. Predictors of discharge stability in the first year following hospital admission for a frail elderly population. Intern Med J. 2008 Sep 4. Epub ahead of print. Hildebrandt P, Richards AM. NT-proBNP testing in high-risk populations: patients with diabetes and with hypertension. Am J Cardiol 2008; 101 (suppl):21A-24A. Hillock RJ, Frampton CM, Yandle TG, Troughton RW, Lainchbury JG, Richards AM. B-type natriuretic peptide infusions in acute myocardial infarction. Heart. 2008 May;94(5):617-22.

212 RESEARCH REPORT 2007/2008 Hollis-Moffatt JE, Merriman ME, Chapman PT, Gow PJ, Harrison AA, Highton J, Jones PB, O’Donnell JL, Stamp LK, and Merriman TR. (2008). Evidence for association of an interleukin-23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Annals of Rheumatic Diseases, Jul 22. Epub ahead of print. Hutchinson CD, Jardine DL, Hurrell M. (2008). Vagolysis. Age Ageing. 37(5):602-4. James SL, Irving PM, Gearry RB, Gibson PR. Management of distal ulcerative colitis: frequently asked questions analysis. Intern Med J. 2008 Feb;38(2):114-9. Januzzi JL, Richards AM. An international consensus statement regarding amino-terminal pro-B-type natriuretic peptide testing. The International NT-proBNP Consensus Panel. Am J Cardiol 2008; 101 (suppl):S1-S2 Jensen BP, Sharp CF, Gardiner SJ and Begg EJ. Development and validation of a stereoselective liquid chromatography-tandem mass spectrometry assay for quantification of S- and R-metoprolol in human plasma. Journal of Chromatography B 2008; 865: 48–54 Kazlauskaite R, Evans AT, Villabona CV, Abdu TAM, Ambrosi B, Atkinson AB, Choi CH, Clayton RN, Courtney CH, Gone EN, Maghnie M, Rose SR, Soule SG, Tordjman K. Corticotropin tests for hypothalamic-pituitary-adrenal insufficiency:a meta- analysis. J Clin Endocrinol Metab 2008:93(11);4245-53. Kelly AP, Robb BJ, Gearry RB. Hypocalcaemia and hypomagnesaemia: a complication of Crohn’s disease. N Z Med J. 2008 Dec 12;121(1287):77-9. Kelly PT, Swanney MP, Seccombe LM, Frampton C, Peters MJ, Beckert LE. Air travel hypoxaemia versus the hypoxia inhalation test in passengers with COPD*. Chest 2008; 133:920-6 Kerse, N., Falloon, K., Moyes, S., Hayman, K., Dowell, T. Kolt, G., Elley,C.R., Hatcher, S. Peri, K., Keeling, S. Robinson E. Parsons, J. Wiles, J. and Arroll, B. (2008). DELLITE. Depression in Late Life: an Intervention Trial of Exercise; Design and recruitment of a randomised controlled trial, BMC Geriatrics, 8:12doi:10.1186/1471-2318-8-12. Kerse N, Peri K, Robinson E, Wilkinson T, von Randow M, Kiata L, Parsons J, Latham N, Parsons M, Willingale J, Brown P, Arroll B. Does a functional activity programme improve function, quality of life, and falls for residents in long term care? Cluster randomised controlled trial. BMJ. 2008 Oct 9;337:a1445 Kleinstreuer N, David T, Plank M, Endre Z. Dynamic Myogenic Autoregulation in the Rat Kidney: A Whole Organ Model. Amer J Physiol. 2008 Mar 19; Epub ahead of print. Kyle PM. Fielder JN. Pullar B. Horwood LJ. Moore MP. (2008). Comparison of methods to identify significant proteinuria in pregnancy in the outpatient setting. BJOG: An International Journal of Obstetrics & Gynaecology. 115(4):523-7, Leong RW, Gearry RB, Sparrow MP. Thiopurine hepatotoxicity in inflammatory bowel disease: the role for adding allopurinol. Expert Opin Drug Saf. 2008 Sep;7(5):607-16. Lewis JG, Shand BI, Elder PA, Scott RS. Plasma retinol-binding protein is unlikely to be a useful marker of insulin resistance. Diabetes Res Clin Pract. 2008 Apr;80(1):e13-5. Epub 2008 Jan 14. Lewis JG, Shand BI, Frampton CM, Elder PA, Scott RS. Plasma Levels of Sex Hormone-binding Globulin, Corticosteroid- binding Globulin and Cortisol in Overweight Subjects who Develop Impaired Fasting Glucose: A 3-Year Prospective Study. Horm Metab Res. 2008 Oct 23. Epub ahead of print. Lewis JG, Shand BI, Frampton CM, Elder PA, Scott RS. Plasma retinol-binding protein is not a marker of insulin resistance in overweight subjects: a three year longitudinal study. Clin Biochem. 2008 Sep;41(13):1034-8. Littlejohn, M.D., Palmer, B.R., Richards, A.M., Frampton, C.M., Pilbrow, A.P., Troughton, R.W., Cameron, V.A., Kennedy, M.A. (2008). Ile164 variant of β2-adrenoceptor does not influence outcome in congestive heart failure but may interact with β blocker treatment. European Journal of Heart Failure 10:55-59. Martinez-Rumayor A, Richards AM, Burnett JC, Januzzi JL. Biology of natriuretic peptides. Am J Cardiol 2008; 101 (suppl):3A-8A McKean A, Vella-Brincat J, Begg E. Prescribing and monitoring clozapine in Christchurch. Australas Psychiatry. 2008 Aug;16(4):263-7. McKinlay A, Grace RC, Dalrymple-Alford JC, Anderson T, Fink J, Roger D. A profile of neuropsychiatric problems and their relationship to quality of life for Parkinson’s disease patients without dementia. Parkinsonism Relat Disord. 2008;14(1):37-42. McKinlay A, Grace RC, Dalrymple-Alford JC, Roger D, Anderson T, Fink J. The accuracy of the Unified Parkinson’s Disease Rating Scale (UPDRS-Section 1) as a screening measure for depression. Parkinsonism Relat Disord. 2008;14(2):170-2. McKinlay A, Kaller CP, Grace RC, Dalrymple-Alford JC, Anderson TJ, Fink J, Roger D. Planning in Parkinson’s disease: a matter of problem structure? Neuropsychologia. 2008 Jan 15;46(1):384-9. McKinlay A, Grace RC, Dalrymple-Alford JC, Anderson TJ, Fink J, Roger D. Neuropsychiatric problems in Parkinson’s disease: comparisons between self and caregiver report. Aging Ment Health. 2008 Sep;12(5):647-53. Miller LJ, Pearce J, Barnett R, Willis JA, Darlow BA, Scott RS. Is population mixing associated with childhood type 1 diabetes in Canterbury, New Zealand? Soc Sci Med. 2008 Dec 30. [Epub ahead of print] Molyneux S, Florkowski CM, George PM, Pilbrow AP, Frampton CM, Lever M, Richards AM. (2008). Coenzyme Q10: an independent predictor of mortality in chronic heart failure J Am Coll Cardiol 29(2):71-82. Moorhead KT, Lee, D, Chase, JG, Moot, AR, Ledingham, KM, Scotter J. Allardyce RJ , Senthilmohan ST, Endre Z. Classifying Algorithms for SIFT-MS Technology and Medical Diagnosis. Computer Methods and Programs in Biomedicine. 2008, 89: 226–238. Myall DJ, MacAskill MR, Davidson PR, Anderson TJ, Jones RD. Design of a modular and low-latency virtual-environment platform for applications in motor adaptation research, neurological disorders, and neurorehabilitation. IEEE Trans Neural Syst Rehabil Eng. 2008 Jun;16(3):298-309.

Division of HEALTH SCIENCES 213 Nicholls MG. Treating hypertension prevents heart failure. Current Hypertens Reports 2008:10;424-425. Nicholls MG, Frampton CM, Yandle TG. BNP: not just for heart failure. Heart. 2008 Jan;94(1):6-7. Nicholls MG, Lewis LK, Yandle TG, Lord G, McKinnon W, Hilton PJ. Ouabain, a circulating hormone secreted by the adrenals, is pivotal in cardiovascular disease. Fact or fantasy? J Hypertens. 2009 Jan;27(1):3-8. Obineche EN, Saadi H, Benedict S, Pathan JY, Frampton CM, Nicholls MG. Inter-relationships between B-type natriuretic peptides and vitamin D in patients on maintenance peritoneal dialysis. Periton Dialysis Int 2008;28:617-621. Palmer, B.R., Jarvis, M.D., Pilbrow, A.P., Ellis, K.L., Frampton, C.M., Skelton, L., Yandle, T.G., Doughty, R.N., Whalley, G.W., Ellis, C.J., Troughton, R.W., Richards, A.M., Cameron, V.A. (2008). Angiotensin-converting enzyme 2 A1075G polymorphism is associated with survival in an acute coronary syndrome cohort. American Heart Journal 156:752-758. Palmer, B.R, Pilbrow A.P, Frampton, C.M., Yandle, T.G., Skelton L., Nicholls, M.G. and Richards, A.M. (2008). Plasma aldosterone levels during hospitalization are predictive of survival post- myocardial infarction. European Heart Journal 29 (20) 2489–2496. Pearson LJ, Yandle TG, Nicholls MG, Evans JJ. Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides. 2008 Jun;29(6):1057-61. Peebles K, Richards M, Celi L, McGrattan K, Murrell C, Ainslie PN. Human cerebral arteriovenous vasoactive exchange across the human brain; regulation by arterial blood gases J Appl Physiol 105(4):1060-8. Peri K, Kerse N, Kiata L, Wilkinson T, Robinson E, Parsons J, Willingale J, Parsons M, Brown P, Pearson J, von Randow M, Arroll B. Promoting independence in residential care: successful recruitment for a randomized controlled trial. J Am Med Dir Assoc. 2008 May;9(4):251-6. Pilbrow, A.P., Ellmers, L.J., Black, M., Moravec, C.S., Sweet, W.E., Troughton, R.W., Richards, A.M., Frampton. C.M., Cameron, V.A. (2008). Genomic selection of reference genes for real-time PCR in human heart tissue BMC Medical Genomics, 1:64. Prickett TC, Barrell GK, Wellby M, Yandle TG, Richards AM, Espiner EA. Effect of sex steroids on plasma C-type natriuretic peptide forms: stimulation by oestradiol in lambs and adult sheep. J Endocrinol. 2008 Dec;199(3):481-7. Prickett TC, Dixon B, Frampton C, Yandle TG, Richards AM, Espiner EA, Darlow BA. Plasma amino-terminal pro C-type natriuretic Peptide in the neonate: relation to gestational age and postnatal linear growth. J Clin Endocrinol Metab. 2008 Jan;93(1):225-32. Prosser H, Forster ME, Richards AM, Pemberton CJ. (2008). Urotensin II and Urotensin II-Related Peptide (URP) in cardiac ischemia reperfusion injury. Peptides 29(5):770-7. Rademaker MR, Charles CJ, Nicholls MG, Richards AM. Hemodynamic, hormonal and renal actions of Adrenomedullin 2 in experimental heart failure Circulation (heart failure) 2008;1:134-132 Rademaker MR, Charles CJ, Nicholls MG, Richards AM. Urocortin2 combined with angiotensin-converting enzyme inhibition in experimental heart failure Clinical Science 2008;114:635-642 Richards AM. Serial measurements of plasma B-type natriuretic peptides: what do they tell us? J Am Coll Cardiol. 2008 Sep 16;52(12):1004-5. Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy MA, Barclay ML, Merriman TR. Confirmation of association of IRGM and NCF4 with ileal Crohn’s disease in a population-based cohort. Genes Immun. 2008 Sep;9(6):561-5. Roberts RL, Gearry RB, Bland MV, Sies CW, George PM, Burt M, Marinaki AM, Arenas M, Barclay ML, Kennedy MA. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenet Genomics 2008 May;18(5):434-438. Rowan JA. Hague WM. Gao W. Battin MR. Moore MP. (2008). MiG Trial Investigators. Metformin versus insulin for the treatment of gestational diabetes. New England Journal of Medicine. 358(19):2003-15. Sanders J, Pithie A, Ganly P, Surgenor L, Wilson R, Merriman E, Loudon G, Judkins R, Chambers S. A prospective double- blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother. 2008 Oct;62(4):809-15 Saadi H, Nagelkerke N, Carruthers SG, Benedict S, Abdulkhalik S, Reed R, Lukic M, Nicholls MG. Association of TCF7L2 polymorphism with diabetes mellitus, metabolic syndrome, and markers of beta cell function and insulin resistance in a population-based sample of Emirati subjects. Diabetes Res Clin Pr 2008;80:392-398. Schouten BJ, Doogue MP, Soule SG, Hunt PJ. Iron polymaltose-induced FGF23 elevation complicated by hypophosphataemic osteomalacia. Ann Clin Biochem. 2009 Jan 16. Epub ahead of print. Soule S, Florkowski C, Potter H, Pattison D, Swan M, Hunt P, George P. Intermittent severe, symptomatic hyponatraemia due to the nephrogenic syndrome of inappropriate antidiuresis. Ann Clin Biochem 2008:45;520-3. Stamp, L.K, A Easson, U Lehnigk, J Highton, and PA Hessian. Absence of IL-17 in rheumatoid nodules – Different T cell subsets in the nodule and synovial membrane. Arthritis and Rheumatism 2008;58(6);1601-08. Stamp LK, O’Donnell JL, Chapman PT, Barclay ML, Kennedy MA, Frampton CM, Roberts RL. Lack of association between HLA-G 14 bp insertion/deletion polymorphism and response to long-term therapy with methotrexate response in rheumatoid arthritis. Ann Rheum Dis. 2009 Jan;68(1):154-5. Stewart RH, Kerr, AJ, Cowan BR, Young AA, Occleshaw C, Richards AM, Edwards C, WhalleyY GA, Freidlander D, Williams M, Doughty RN, Zeng I, White HD for the ZEST Investigators. A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis. Am Heart J 2008;156:348-55 Sung EY, Moore MP, Lunt H, Doogue M, Zhang M, Begg EJ. Do thiazide diuretics alter the pharmacokinetics of metformin in patients with type 2 diabetes already established on metformin? Br J Clin Pharmacol. Epub 2008 Sep 23. Sutherland AD, Gearry RB, Frizelle FA. Review of fecal biomarkers in inflammatory bowel disease. Dis Colon Rectum. 2008 Aug;51(8):1283-91.

214 RESEARCH REPORT 2007/2008 Tarrant KM, Barclay ML, Frampton CM, Gearry RB. Perianal disease predicts changes in Crohn’s disease phenotype-results of a population-based study of inflammatory bowel disease phenotype. Am J Gastroenterol. 2008 Dec;103(12):3082-93. Taylor, W.J., AA Harrison, J Highton, P Chapman, L Stamp, et al. The Disease Activity Score 28 erythrocyte sedimentation rate (DAS28-ESR) bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgment. Rheumatology 2008;47;524-518. Taylor DR, Jayaram L, Asher MI, Epton MJ. “As-required” combination therapy with inhaled corticosteroids and long-acting beta-2 agonists for asthma: current evidence and recommendations. NZ Med J. 2008 Nov 7;121(1285):106-18. Review. Taylor, W.J., HR Schumacher Jr, HSB. Baraf, P Chapman, LK Stamp, et el. A Modified Delphi Exercise To Determine The Extent Of Consensus With OMERACT Outcome Domains For Studies Of Acute And Chronic Gout. Annals of Rheumatic Diseases 2008;67;888-891. The ONTARGET Investigators Telmisartan, Ramipril, or both in patients at high risk for vascular events New Engl J Med 2008;358:1547-59. (Richards A.M. as a named investigator) Troughton RW, Richards AM. Outpatient monitoring and treatment of chronic heart failure guided by NT-proBNP measurement. Am J Cardiol 2008; 101 (suppl):72A-75A Tweed M, Wilkinson T. A randomized controlled trial comparing instructions regarding unsafe response options in a MCQ examination. Med Teach. 2008 Sep 29:1-4. van Stockum S, MacAskill M, Anderson T, Dalrymple-Alford J. Don’t look now or look away: two sources of saccadic disinhibition in Parkinson’s disease? Neuropsychologia. 2008 Nov;46(13):3108-15. Wallace AJ, Eady SL, Scott RS, Willis JA, Frampton CM. Considerable temporal variability in glucose reference curves in humans for a year period. Nutr Res. 2008 Aug;28(8):495-500. Whalley GA, Wright SP, Pearl A, Gamble GD, Walsh HJ, Richards AM, DoughtyY RN. Prognostic role of echocardiography and brain natriuretic peptide in symptomatic breathless patients in the community Eur Heart J 2008; 29(4):509-516 Wickens K, Ingham T, Epton M, Pattemore P, Town I, Fishwick D, Crane J; New Zealand Asthma and Allergy Cohort Study Group. The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clin Exp Allergy. 2008 Aug;38(8):1318-24. Wiles, J., Allen, R., Kerse, N., Palmer, A., Keeling, S. and Hayman, K. (2008). Older people and their social spaces: a study of attachment to place in Aotearoa New Zealand. Social Science and Medicine. Dec 23. Epub ahead of print. Wilkinson TJ. Altruism and the unmeasured effects of medical student loans. N Z Med J. 2008 May 9;121(1273):9-10. Wilkinson TJ. The science of medical education. NZ Med J. 2008 Sep 22;121(1282):5-7. Wilkinson TJ, Campbell PJ, Judd SJ. Reliability of the long case. Med Educ. 2008 Sep;42(9):887-93 Wilkinson TJ, Smith JD, Margolis SA, Sen Gupta T, Prideaux DJ. Structured assessment using multiple patient scenarios by videoconference in rural settings. Med Educ. 2008 May;42(5):480-7. Wilson K, Widdowson M, Swanney M, Meyer R, Singh H, Beckert L. Chronic dyspnea and wheezing in a 46-year-old nonsmoker. Chest. 2008 Apr;133(4):1034-7. Young RP, Hopkins RJ, Hay BA, Epton MJ, Black PN, Gamble GD. Lung cancer gene associated with COPD: triple whammy or possible confounding effect? Eur Respir J. 2008 Nov;32(5):1158-64. Young JM, Strey CH, George PM, Florkowski CM, Sies CW, Frampton CM, Scott RS. Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure. Eur J Heart Fail. 2008 May;10(5):463-6. Epub 2008 Apr 21.

Journal – Other Bird PA, Begg EJ. Rapid clearance of methylprednisolone after intratympanic application in humans. Comment on letter to the Editor in relation to the above. Otology and Neurotology 2008 29(5):733. Dachs, G., Currie, M., McKenzie, F., Jeffreys, M., Cox, B., Foliaki, S., Le Marchand, L., Robinson, B. Cancer disparities in indigenous Polynesian people: Mäori, Native Hawaiians and Pacific People. Lancet Oncology, 2008; 9:473-84.

Report Keeling. S., Glasgow,K. and Morris, C. (2008). Grandparents in rural families: young people’s perspectives. Blue Skies Report, No 24/08, Families Commission.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Journal – Research Article Kyle PM, Fielder JN, Pullar B, Horwood LJ, Moore MP. (2008). Comparison of methods to identify significant proteinuria in pregnancy in the outpatient setting. BJOG.115(4):523-7. Pearson LJ, Yandle TG, Nicholls MG, Evans JJ. (2008). Regulation of endothelin-1 release from human endothelial cells by sex steroids and angiotensin-II. Peptides. 29(6):1057-61. Peters EE, Towler KL, Mason DR, Evans JJ. (2008). Effects of Galanin and Leptin on Gonadotropin-Releasing Hormone- Stimulated Luteinizing Hormone Release from the Pituitary. Neuroendocrinology. Aug 14. epub ahead of print.

Division of HEALTH SCIENCES 215 Sykes PH, Harker DY, Miller A, Whitehead M, Neal H, Wells JE, Peddie D. (2008). A randomised comparison of SurePath liquid-based cytology and conventional smear cytology in a colposcopy clinic setting. BJOG. 115(11):1375-81. Wakeman S, Benny P. (2008). Is it possible to predict a fertile cycle? Uteroovarian blood flow parameters in conception versus nonconception cycles. Fertil Steril. 8 Jul 29, epub ahead of print.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF ORTHOPAEDIC SURGERY AND MUSCULOSKELETAL MEDICINE

Chapter in Book Woodfield, T. Hutmacher, D. Dalton, P. Lewis, J. (2008). Scaffold Design and Fabrication. In: Textbook on Tissue Engineering, C A van Blitterswijk, A Lindahl, P Thomsen, D F Williams, J Hubbell, R Cancedda (Eds). Academic Press. Woodfield, T. Malda, J. Radisic, M. Levenberg, S. Oomens, C. Baaijens, F. Svalander, S. Vunjak-Novakovic. G. (2008). Cell Nutrition,. In: Textbook on Tissue Engineering, C A van Blitterswijk, A Lindahl, P Thomsen, D F Williams, J Hubbell, R Cancedda (Eds). Academic Press.

Journal – Research Article Dunn, J.A Sinnott, A.K. Nunnerley, J.L. Scheuringer, M. (2008). Utilization of patient perspective to validate clinical measures of outcome in spinal cord injury. Disability and Rehabilitation, Dec 29:1-9. Epub ahead of print. Dunn, J.A. Sinnott, A.K. Bryden, A.M. Connolly, S.J. Rothwell, A.G. (2008). Measurement Issues Related to Upper Limb Interventions in Persons Who Have Tetraplegia. Hand Clinics 24, No 2, 161-168. Hooper, G.J, Hooper, N.M. Rothwell, A.G. Hobbs. T. (2008). Bilateral Total Joint Arthroplasty – The Results of the New Zealand Joint Register. Journal of Arthroplasty, Dec 2. Epub ahead of print. Rothwell, A.G. (2008). Dedication – Alan Maxwell Clarke (1932-2007). Hand Clinics, 24, No 2, ix-v. Selvarajah, E., G.J. Hooper (2008). Restoration of the joint line in mobile bearing total knee arthroplasty. J Arthroplasty, Aug 29. Epub ahead of print. Talbot S, Hooper G, Stokes A, Zordan R. Use of a New High-Activity Arthroplasty Score to Assess Function of Young Patients With Total Hip or Knee Arthroplasty. J Arthroplasty. 2008 Dec 2. Epub ahead of print.

Report Hooper, G.J. (2008). Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago, Christchurch – Self-Review Report. pp. 23.

Commissioned Report Rothwell, A.G. Hobbs, T. Frampton, C. (2008). National Joint Registry Nine Year Report – January 1999 to December 2007. For the New Zealand Orthopaedic Association, Christchurch, New Zealand.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PAEDIATRICS

Chapter in Book Pattemore PK, & Jennings LC. 2008. Epidemiology of Respiratory Infections, In: Pediatric Respiratory Medicine, 2nd Ed, Taussig, Landau, eds. Chapter 31, Part 7.

Journal – Research Article Asher MI, Stewart AW, Clayton T, Crane J, Ellwood P, MacKay R, Mitchell E, Moyes C, Pattemore PK, Pearce N. Has the prevalence and severity of symptoms of asthma changed among children in new Zealand? ISAAC Phase Three. The New Zealand Medical Journal 2008; 121: 52-63. Ch’ng S, Low I, Ng D, Brasch H, Sullivan M, Davis P, Tan ST. Epidermal growth factor receptor, a novel biomarker for aggressive head and neck cutaneous squamous cell carcinoma. Human Pathology 2008; 39: 344-349. Darlow BA, Elder MJ, Horwood J, Donoghue DD, Henderson-Smart DJ. Does observer bias contribute to variations in the rate of retinopathy of prematurity between centres? Clinical and Experimental Ophthalmology 2008; 36: 43-36. Dixon B, Darlow B, Prickett T. How useful is knemometry in measuring meonatal growth? Journal of Paediatrics and Child Health 2008; 44: 444-448. Fisher M, Meates-Dennis M. Is interval appendectomy necessary after successful conservative treatment of appendiceal mass in children? Archives of Disease in childhood, 2008; 93(7):631-633. Miller LJ, Pearce J, Barnett R, Willis JA, Darlow BA, Scott RS. Is population mixing associated with childhood type 1 diabetes in Canterbury, New Zealand? Social Science & Medicine, 2008 Dec 30. Epub ahead of print. Pattemore PK. Intermittent asthma in children. New Zealand Family Physician, 2008; 35: 207-10. Prickett TCR, Dixon B, Frampton C, Yandle TG, Richards M, Espiner EA, Darlow BA. Plasma amnio-terminal pro C-type natriuretic peptide in the neonate: relation to gestational age and postnatal linear growth. Journal of Clinical Endocrinology and Metabolism January 2008, 93(1): 225-232.

216 RESEARCH REPORT 2007/2008 Schmid J, Ling LJ, Leung JLS, Zhang N, Kolbe J, Wesley AW, Mills GD, Brown PJ, Jones DT, Laing RTR, Pattemore PK, Taylor DR, Grimwood K. Pseudomonas aeruginosa transmission is infrequent in New Zealand cystic fibrosis clinics. European Respiratory Journal 2008; 32: 1583-1590 Stamp L, Beckert L, Lambie N, MacDonald S, Meates-Dennis M. Pulmonary haemorrhage in a 13-year-old girl: An unusual presentation of systemic lupus erythematosus. Journal of Paediatrics and child Health 2008; 44: 743-745. Wickens K, Ingham T, Epton M, Pattemore PK, Town I, Fishwick D, Crane J, and the New Zealand Asthma and Allergy Cohort Study Group. The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clinical and Experimental Allergy 2008; 38: 1318-1324.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PATHOLOGY

Chapter in Book Hunt MA, Dachs GU, Currie MJ. 2008. Vascular targeted gene therapy in cancer treatment. In New Gene Therapy and Cancer Research, (Chapter IV, pp. 145-182), Ed. WB Gustafsson. Nova Science Publishers Inc., New York.

Journal – Research Article Atkinson, W., Elmslie, J., Lever, M., Chambers, ST., George, PM. Dietary and supplementary betaine: acute effects on plasma betaine and homocysteine concentrations under standard and postmethionine load conditions in healthy male subjects. Am J Clin Nutr. 87;(3):577-85. 2008. Bentley, RW., Keenan, JI., Gearry, RB., Kennedy, MA., Barclay, ML., Roberts, RL. Incidence of mycobacterium avium subspecies paratuberculosis in a population-based cohort of patients with Crohn’s disease and control subjects. American Journal of Gastroenterology 103;(5):1168-1172. 2008. Brennan, SO. Fifty-eight years of haemoglobin analysis. Clin Chem 54:8-10. 2008. Brennan, SO., Owen, MC., Chan, T., Ruscova, A. Novel hemoglobin α chain elongation resulting from a 15-residue insertion and tandem duplication of the F helix. Clin Biochem 41:1156-61. 2008. Brown, KK., Eriksson, SE., Arnér, ES., Hampton, MB. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates. Free Radic Biol. Med. 45;(4):494-502. 2008. Caram, LB., Linefsky, JP., Read, KM., Murdoch, DR., Lalani, T., Woods, CW., Reller, LB., Kanj. SS., Premru, MM., Ryan, S., Al-Hegelan, M., Donnio, PY., Orezzi, C., Paiva, MG., Tribouilloy, C., Watkin, R., Harris, O., Eisen, DP., Corey, GR., Cabell, CH., Petti, CA. International Collaboration on Endocarditis Investigator Group. Leptotrichia endocarditis: Report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases. Eur J Clin Microbiol Infect Dis 27:139-143. 2008. Chapman, AL., Skaff, O., Senthilmohan, R., Kettle, AJ., Davies, MJ. Hypobromous acid and bromamine production by neutrophils and their modulation by superoxide. Biochem J. 2008, Oct 14. [Epub ahead of print]. Chew, JS., Saleem, M., Florkowski, CM., George, PM. Cystatin C-a paradigm of evidence based laboratory medicine. Clin Biochem Rev. 29;(2):47-62. 2008. Chitcholtan, K., Hampton, MB., Keenan, JI. Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis 29: 2400-2405. 2008. Clark, DWJ., Ashton, JA., Wallace, AK., Zhou, L., Kennedy, MA. Pharmacogenetic investigation using a pharmacovigilance database. PharmacoVigilance Review, 2;9-13. 2008. Coker, MS., Hu, WP., Senthilmohan, ST., Kettle, AJ. Pathways for the decay of organic dichloramines and liberation of antimicrobial chloramine gases. Chem. Res. Toxicol. 2008, Nov 4. [Epub ahead of print]. Cox. AG., Brown, KK., Arnér, EJS., Hampton, MB. The thioredoxin reductase inhibitor auranofin triggers apoptosis through a Bax/Bak-dependent process that involves peroxiredoxin 3 oxidation. Biochem. Pharmcol. 76:1097-109. 2008. Cox, AG., Pullar, JM., Hughes, G., Ledgerwood, EC., Hampton, MB. Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis. Free Radic. Biol. Med. 44;(6):1001-1009. 2008. Cuddihy, SL., Parker, A., Harwood, DT., Vissers, MC., Winterbourn, CC. Ascorbate interacts with reduced glutathione to scavenge phenoxyl radicals in HL60 cells. Free Radic Biol Med. April 15;44(8):1637-44. 2008 Cuddihy, SL., Brown, KK., Thomson,. SJ., Hampton MB, Induction of apoptosis by isothiocyanate in cells overexpression Bcl- XL. Cancer Lett. 271(2):215-21, 2008. Dachs, GU., Currie, MJ., McKenzie, F., Jeffreys, M., Cox, B., Foliaki, S., Le Marchand, L., Robinson, BA. Cancer disparities in indigenous Polynesian populations: Mäori, Native Hawaiians, and Pacific people. Lancet Oncol 9;(5):473-84. 2008. Davis, RL., Baker, B., Brennan, SO. Fibrinogen Foxton; novel BβA277V mutation causing low normal plasma fibrinogen concentration. Thromb Haemost. 100:807-10. 2008. Davis, RL., Homer, VM. George, PM. Brennan, SO. A deep intronic mutation in FGB creates a consensus exonic splicing enhancer motif which leads to aberrant mRNA splicing and afibrinogenemia that can be corrected in vitro with antisense oligonucleotide treatment. Human Mutation, 100(4):708-10. Davis, RL., Peter, T., Brennan, SO. Novel frameshift in the serum albumin gene results in analbuminemia through premature truncation and post translational modification. Clin Biochem 41:1482-1485. 2008.

Division of HEALTH SCIENCES 217 Durante-Mangoni, E., Bradley. S., Selton-Suty, C., Tripodi, M-F., Barsic, B., Bouza, E., Cabell, CH., de Oliveira, Ramos, AI., Fowler, V., Hoen, B., Konecny, P., Moreno, A., Murdoch, D., Pappas, P., Sexton, DJ., Spelman, D., Tattevin, P., Miro, JM., van der Meer, JTM., Utili, R for the International Collaboration on Endocarditis Prospective Cohort Study Group. Current features of infective endocarditis in elderly patients. Arch Intern Med 168;(19):2095-103. 2008. Favaloro, EJ., Patterson D., Denholm, A., Mead, S., Gilbert, A., Collins, A., Estell, J. George, PM., Smith, MP. Differential identification of PT-VWD from type 2B VWD and GP1BA nomenclature issues response to Othman. Br J Haematol. 2008. Florkowski, CM., Molyneux, SL., George, PM. Rosuvastatin in older patients with systolic heart failure. N Engl J Med 20;358(12):1301. 2008. Florkowski, CM., Southby, SJ., George, PM. Revised national guidelines for analysis of CSF for bilirubin in suspected SAH. Ann Clin Biochem 45; (Pt 6):617-8. 2008. Fraser, M., Bennett, L., Van Zijl, PL., Mocatta, TJ., Williams, CE., Gluckman, PD, Winterbourn, CC., Gunn, AJ. Extracellular amino acids and lipid peroxidation products in periventricular white matter during and after cerebral ischemia in preterm fetal sheep. J Neurochem. Mar 18. 2008. Ganly, PS., Keenan, H., Spearing, RL., Smith, MP., Patton, N., Merriman, EG., Gibbons, SS. Written advice can provide a safe and acceptable alternative to a new patient assessment for selected referrals to haematologists. Med J Aust 188;(1):9-11. 2008. Ganly, P., Saleem, M., Marr, M., Burt, M., Florkowski, C., Williamson, A. Not walking or communicating--is all well? Lancet 2008. 372(9655):2086. George, PM., Saigal, R., Lawlor, MW., Moore, MJ., Lavan, DA., Marini, RP., Selig, M., Makhni, M., Burdick, JA., Langer, R., Kohane, DS. Three dimensional conductive constructs for nerve regeneration. J Biomed Mater Res A. 2008. Harwood, DT., Nimmo, SL., Kettle, AJ., Winterbourn, CC., Ashby, MT. Molecular structure and dynamic properties of a sulfonamide derivative of glutathione that is produced under conditions of oxidative stress by hypochlorous acid. Chem. Res. Toxicol. 21;(5):1011,1016. 2008. Hien, VT., Lam, NT., Khan, NC., Dung, NT., Skeaff, CM., Venn, BJ., Walmsley, T., George, PM., McLean. J., Brown, MR., Green, TJ. Folate and vitamin B12 status of women of reproductive age living in Hanoi City and Hai Duong Province of Vietnam. Public Health Nutr. 27:1-6. 2008. Homer, VM., Marais, AD., Charlton, F., Laurie, AD., Hurndell, N., Scott, R., Mangili, F., Sullivan, DR., Barter, PJ., Rye, KA., George, PM., Lambert, G. Identification and characterisation of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South Africa. Atherosclerosis 196;(2):659-66. 2008. Huggan, PJ., Murdoch, DR. Fusobacterial infections: clinical spectrum and incidence of invasive disease. J Infect 57;(4):283-9. 2008 Huggan, PJ., Murdoch, DR., Gallagher, K., Chambers, ST. Concomitant staphylococcus aureus bacteriuria is associated with poor clinical outcome in adults with S. aureus bacteraemia. J Hosp Infect 69;(4):345-9. 2008. Jennings, LC., Anderson, TP., Beynon, KA., Chua, A., Laing, RTR., Werno, AM., Young, SA, Chambers, ST., Murdoch, DR. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax 63;(1):42-8. 2008. Keith, ER., Murdoch, DR. Antimicrobial susceptibility profile of streptococcus pseudopneumoniae isolated from sputum. Antimicrob Agents Chemother 52;(8):2998. 2008. Lea, RA., Roberts, RL., Green, MR., Chambers, GK., Kennedy, MA. Allele frequency differences of cytochrome P450 polymorphisms in New Zealand Mäori. NZ Med J 121;(1272):33-37. 2008. Le Couteur, DG., Warren, A., Cogger, VC., Smedsrod, B., Sorensen, KK., De Cabo, R., Fraser, R., McCuskey, RS. Old age and the hepatic sinusoid. Anat Rec (Hoboken) 291;(6):672-83. Review. 2008. Lever, M., Slow, S., McGregor, D., Dellow, W., George, PM., Chambers, ST. Betaine metabolism is disturbed in diabetes: implications of Methionine load tests and sorbitol excretions. 2008. Littlejohn, MD., Palmer, BR., Pilbrow, A., Richards, AM., Frampton, CM., Troughton, RW., Cameron, AV., Kennedy, MA. Ile164 variant of beta 2-adrenoceptor does not influence outcome in congestive heart failure but may interact with beta- blocker treatment. European Journal of Heart Failure 10; 55-59. 2008. Low, FM., Hampton, MB., Winterbourn, CC. Peroxiredoxin 2 and peroxide metabolism in the erythrocyte. Antioxid, Redox Signal. 10;(9):1621-1629. 2008. Mackay, RJ., Florkowski, CM., George, PM, Sies, CW., Woods, S. Uncertainty of sweat chloride testing: does the right hand know what the left hand is doing? 45; (Pt 6):535-8. 2008. McHugh, P.C., Rogers, G.R., Glubb, D.M., Allington, M.D., Hughes, M., Joyce, P.R., Kennedy, MA. (2008). Downregulation of Ccnd1 and He26 in rat hippocampus after chronic exposure to the antidepressant paroxetine. Acta Neuropsychiatrica 20, 307-313. McHugh, PM., Rogers, GR., Loudon, B., Glubb, DG., Joyce, PR., Kennedy, MA. Proteomic analysis of embryonic stem cell- derived neural cells exposed to the antidepressant paroxetine. Journal of Neuroscience Research 86;306-316. 2008. Meotti, FC., Senthilmohan, R., Harwood, DT., Missau, FC., Pizzolatti, MG., Kettle, AJ. Myricitrin as a substrate and inhibitor of myeloperoxidase: implications for the pharmacological effects of flavonoids. Free Radic. Biol. Med. 44;(1):109-120. 2008. Molyneux, SL., Young, JM., Florkowski, CM., Lever, M., George, PM. Coenzyme q10: is there a clinical role and a case for measurement? Clin Biochem Rev. 29;(2):71-82. 2008. Murdoch, DR. Raising the profile of pneumococcal disease. Intern Med J 38;(6):381-3. 2008. Murdoch, D. The Third Regional Pneumococcal Symposium, Istanbul, Turkey. Drugs 11;(4):242-244. 2008. Petti, CA., Simmon, KE., Miro, JM., Hoen, B., Marco, F., Chu, VH., Athan, E., Bukovski, S., Bouza, E., Bradley, S., Fowler, VG., Giannitsioti, E., Gordon, D., Reinbott, P., Korman, T., Lang, S., Garcia-de-la-Maria, C., Raglio, A., Morris, AJ., Plesiat, P., Ryan, S., Doco-Lecompte, T., Tripodi, F., Utili, R., Wray, D., Federspiel, JJ., Boisson, K., Barth Reller, L., Murdoch, DR,

218 RESEARCH REPORT 2007/2008 Woods, CW., and the International Collaboration on Endocarditis – Microbiology Investigators. Genotypic diversity of coagulase-negative staphylococci causing endocarditis: a global perspective. J Clin Microbiol 46;(5):1780-4. 2008. Piuhola, J., Kerkelä, R., Kennan, JI., Hampton,. MB., Richards, AM, Pemberton, CJ. Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia-reperfusion injury. Clin. Sci (Lond) 114;(4):293-304. 2008. Roberts, RL., Gearry R., Sies, C., George, P., Burt, M., Marinaki, A., Barclay, M., Kennedy, MA. Trinucleotide repeat variants in the promoter of the thiopurine S-methyltransferase gene of patients exhibiting ultra-high enzyme activity. Pharmacogenetics and Genomics 18;(5):434-438. 2008. Roberts, RL., Gearry, RB., Kennedy, MA., Barclay, ML. Beyond TPMT: genetic influences on thiopurine drug responses in inflammatory bowel disease. Personalized Medicine 5;(3):233-248. 2008. Roberts, RL. Hollis-Moffat, JE., Gearry, RB., Kennedy, MA, Barclay, ML. Merriman, TR. Confirmation of association of NCF4 and IRGM with ileal Crohn’s disease in a population-based cohort. Genes & Immunity 9;(6):561-565. 2008. Porter, RL., Mulder, RT., Joyce, PR., Miller, AL., Kennedy, MA. Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. J Affect Disorders 109; 209-212. 2008. Sanders, J., Pithie, A., Ganly, P., Surgenor, L., Wilson, R., Merriman, E., Loudon G., Judkins, R., Chambers S. A prospective double- blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother 62;(4):809-815. 2008 Senthilmohan, ST., Kettle, AJ., McEwan, MJ., Drummer, J., Edwards, SJ., Wilson, PF, Epton,. MJ. Detection of monobromamine, monochloramine and dichloaramine using selected ion flow tube mass spectrometry and their relevance as breath markers. Rapid Commun. Mass Spectrom. 22;(5):677-681. 2008. Simmon, KE., Hall, L., Woods, CW., Marco, F., Miro, JM., Cabell, C., Hoen, B., Marin, M., Utili, R., Giannitsioti, E., Doco- Lecompte, T., Bradley, S., Mirrett, S., Tambic, A., Ryan, S., Gordon, D., Jones, P., Korman,. T., Wray, D., Barth Reller, L., Tripodi, M-F., Plesiat, P., Morris, AJ., Lang, S., Murdoch, DR., Petti, CA and the International Collaboration on Endocarditis Microbiology (ICE-Micro) Investigators. Phylogenetic analysis of viridans group streptococci causing endocarditis. J Clin Microbiol 46;(9):3087-90. 2008. Slow, S., Lever, M., Chambers, ST., George, PM. Plasma dependent and independent accumulation of betaine in male and female rat tissues. Physiol Res July 18. 2008. Soule, S., Florkowski, C., Potter, H., Pattison, D., Swan, M., Hunt, P., George, PM. Intermittent severe, hyponatraemia due to nephrogenic syndrome of inappropriate antidiuresis. Ann Clin Biochem 45:520-3. 2008. Stuffrein-Roberts, S., Joyce, PR., Kennedy, MA. Role of epigenetics in mental disorders. ANZ Journal of Psychiatry 42; 97-107. 2008. Syhre, M. Chambers, ST. The scent of mycobacterium tuberculosis. Tuberculosis (Edinb) Jul; 88;(4): 317-323. 2008 Syhre, M., Scotter, JM., Chambers, ST. Investigation into the production of 2-pentylfuran by aspergillus fumigatus and other respiratory pathogens in vitro and human breath samples. Med Mycol 46;(3):209-15. 2008. Sykes, P., Harker, D., Miller, A., Whitehead, M., Neal, H., Wells, J., Peddie, D. A randomized comparison of SurePath liquid- based cytology and conventional smear cytology in a colposcopy clinic setting. British Journal of Obstetrics and Gynaecology 115:1375-1381. 2008. Thomson, SJ., Cox, AG., Cuddihy, SL., Pullar, JM., Hampton, MB. Inhibition of receptor-mediated apoptosis upon Bcl-2 overexpression is not associated with increased antioxidant status. Biochem. Biophys. Res. Comm. 375;(1):145-150. 2008. Vasudevamurthy, M.K., Lever, M., George, P.M., Morison, K.R. (2008). Betaine structure and the presence of hydroxyl groups alters the effects on DNA melting temperatures. Biopolymers 91, 85-94. Walker, LC., Harris, GC., Wells, JE., Robinson, BA, Morris CM. Assoiation of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes Chromosomes and Cancer 47: 405-17. 2008. Walmsley, TA., Potter, HC., George, PM., Florkowski, CM. Pseudo-hypertriglyceridaemia: a measurement artifact due to glycerol kinase deficiency. Postgrad Med J 2008. Warren, A., Chaberek, S., Ostrowski, K., Cogger, VC., Hilmer, SN., McCuskey, RS., Fraser, R., Le Couteur, DG. Effects of old age on vascular complexity and dispersion of the hepatic sinusoidal network. Microcirculation 15;(3):191-202. 2008. Werno, AM., Murdoch, DR. Laboratory diagnosis of invasive pneumococcal disease. Clin Infect Dis 15;46(6): 926-32. 2008. Wheeler, B., George, PM., Mackenzie, K., Hunt, P., Potter, HC., Florkowski, CM. Three cases of congenital adrenal hypoplasia with novel mutations in the (NROB1) DAX-1 gene. Ann Clin Biochem 45;(Pt 6):606-9. 2008. Winterbourn, CC., Reconciling the chemistry and biology of reactive oxygen species. Nat Chem Biol. May;4(5):278-86. Review. 2008. Winterbourn, CC., Hampton, MB. Thiol chemistry and specificity in redox signaling. Free Radic. Biol, Med. 45;(5):549-61. 2008. Young, JM., Strey CH., George, PM., Florkowski, CM, Sies, CW., Frampton, CM., Scott, RS. Effect of atorvastatin on plasma levels of asymmetric dimethylarginine in patients with non-ischaemic heart failure. Eur J Heart Fail. 10;(5):463-6. 2008. Zimmerman, MD., Murdoch, DR., Rozmajzi, PJ., Basnyat, B., Woods, CW., Richards, AL., Belbase, RH., Hammer, DA., Anderson, TP., Barth Reller, L. Murine typhus and febrile illness, Nepal. Emerg Infect Dis 14;(10):1656-9. 2008.

Reports Ganly, PS. Medical Report – South Island Bone Marrow Cancer Trust: Cancer Genetics Research (14 August 2008). Morris, CM., Harris, GC., Robinson, BA. Research Report – CDHB: FISHing for prognostic gene markers in breast and other cancers (30 September 2008). Morris, CM. Research Report: Molecular pathology of breast cancer translational to diagnosis (23 September 2008). Morris, CM. Invited submission – Annual report of the New Zealand Leukaemia & Blood Foundation: Leukaemia Genetics – Holding ground for better future cancer care in New Zealand (19 September 2008).

Division of HEALTH SCIENCES 219 Morris, CM., Moon, S-Y., Ganly, PS. Research Report – Canterbury Medical Research Foundation for South Island B one Marrow Cancer Trust: High-resolution genomic profiling of chronic lymphocytic leukaemia (19 September 2008). Morris, CM. Conference Report: Decipher, 4th International DECIPHER Symposium, Trust Genome Campus, Hinxton, Cambridgeshire, UK (19-21 May 2008).

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Chapter in Book Crowe M. A discursive approach to the therapeutic relationship. In: Warne T, ed. Creative approaches to mental health care. Palgrave, 2008. Crowe M, Carlyle D. Personality disorders. In: Hodder A, ed. Psychiatric and Mental Health Nursing: The craft of caring. 2nd Edition edn. United Kingdom, 2008. Fergusson D, Horwood L. GAD and MD: Common and reciprocal causes. In: Diagnostic Issues in Depression and Generalized Anxiety Disorder: Refining the Research Agenda for DSM-V: American Psychiatric Press. 2008.

Journal – Research Article Adamson S, Sellman J, Robertson P. Social phobia in an outpatient alcohol and drug treatment sample. Australian and New Zealand Journal of Psychiatry 2008; 42:134-140. Beautrais AL, Mishara BL. World Suicide Prevention Day: “think globally, plan nationally, act locally”. Crisis 2008; 29:59-63. Bedford J, Weggery S, Ellis G, McDonald F, Joyce P, Leader J, Walker R. Lithium-induced nephrogenic diabetes insipidus: renal effects of amiloride. Journal of American Society of Nephrology 2008; 3:1324-1331. Bell C, Bhika S, Porter R, Frampton C, Carter J, McIntosh V, Jordan J, Joyce P. The response to sulpiride in major depression before and after cognitive behavioural therapy: D2 receptor function. Acta Neuropsychiatrica 2008; 20:199-206. Bigwood S, Crowe M. ‘It’s part of the job, but it spoils the job’: a phenomenological study of physical restraint. International Journal of Mental Health Nursing 2008; 17:215-222. Boden J, Fergusson D, Horwood L. Cigarette smoking and suicidal behaviour: results from a 25-year longitudinal study. Psychological Medicine 2008; 38:433-439. Boden JM, Fergusson DM, Horwood LJ. Does adolescent self-esteem predict later life outcomes? A test of the causal role of self-esteem. Dev Psychopathol 2008; 20:319-339. Boden JM, Fergusson DM, John Horwood L. Early motherhood and subsequent life outcomes. Journal of Child Psychology & Psychiatry & Allied Disciplines 2008; 49:151-160. Carter FA, Bulik CM. Childhood obesity prevention programs: how do they affect eating pathology and other psychological measures? Psychosomatic Medicine 2008; 70:363-371. Carter FA, McIntosh VV, Joyce PR, Bulik CM. Weight suppression predicts weight gain over treatment but not treatment completion or outcome in bulimia nervosa. Journal of Abnormal Psychology. 117(4):936-940. Clark CA, Woodward LJ, Horwood LJ, Moor S. Development of emotional and behavioral regulation in children born extremely preterm and very preterm: biological and social influences. Child Dev 2008; 79:1444-1462. Deering D, Sellman J, Adamson S, Horn J, Frampton C. Development of a brief treatment instrument for routine clinical use with methadone maintenance treatment clients: the methadone treatment index. Substance Use and Misuse 2008; 43:1547-1561. Eggleston MJ, Watkins WG. Mental health services for children and adolescents in New Zealand, outcomes, and the Health of the Nation Outcome Scale for Children and Adolescents (HoNOSCA). New Zealand Medical Journal 2008; 121:83-91. Fergusson D, Boden J, Horwood L. Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Abuse and Neglect 2008; 32:607-619. Fergusson D, Horwood L, Boden J. Is driving under the influence of cannabis becoming a greater risk to driver safety than drink driving? Findings from a 25-year longitudinal study. Accident Analysis and Prevention 2008; 40:1345-1350. Fergusson DM, Boden JM. Cannabis use and later life outcomes. Addiction 2008; 103:969-976. Fergusson DM, Boden JM. Cannabis use and adult ADHD symptoms. Drug Alcohol Depend 2008; 95:90-96. Fergusson DM, Boden JM, Horwood LJ. Neonatal circumcision: effects on breastfeeding and outcomes associated with breastfeeding. J Paediatr Child Health 2008; 44:44-49. Fergusson DM, Boden JM, Horwood LJ. Dentine lead levels and criminal behaviour in late adolescence and early adulthood. J Epidemiol Community Health 2008. Fergusson DM, Boden JM, Horwood LJ. The transmission of social inequality: Examination of the linkages between family socioeconomic status in childhood and educational achievement in young adulthood. Research in Social Stratification and Mobility 2008; 26:277-295. Fergusson DM, Boden JM, Horwood LJ. Exposure to childhood sexual and physical abuse and adjustment in early adulthood. Child Abuse and Neglect 2008; 32:607-619. Fergusson DM, Boden JM, Horwood LJ. The developmental antecedents of illicit drug use: evidence from a 25-year longitudinal study. Drug Alcohol Depend 2008; 96:165-177. Fergusson DM, Horwood LJ, Boden JM. Is driving under the influence of cannabis becoming a greater risk to driver safety than drink driving? Findings from a longitudinal study. Accid Anal Prev 2008; 40:1345-1350.

220 RESEARCH REPORT 2007/2008 Friesen MD, Woodward LJ, Fergusson DM, Horwood LJ, Chesney A. Living Standards and Material Conditions of Young New Zealand Families. Social Policy Journal of New Zealand 2008; 33:47-69. Gallagher LM, Kliem C, Beautrais AL, Stallones L. Suicide and occupation in New Zealand, 2001-2005. International Journal of Occupational and Environmental Health 2008; 14:45-50. Gibb S, Fergusson D, Horwood L. Gender differences in educational achievement to age 25. Australian Journal of Education 2008; 52:63-80. Inder ML, Crowe M, Moor S, Luty SE, Carter JC, Joyce PR. “I actually don’t know who I am”: The impact of bipolar disorder on the development of self. Psychiatry: Interpersonal and Biological Processes 2008; 72:123-133. Jordan J, Joyce PR, Carter FA, Horn J, McIntosh VV, Luty SE, McKenzie JM, Frampton CM, Mulder RT, Bulik CM. Specific and nonspecific comorbidity in anorexia nervosa. International Journal of Eating Disorders 2008; 41:47-56. Jordan J, Joyce PR, Carter FA, McIntosh VV, Luty SE, McKenzie JM, Frampton CMA, Bulik CM. The Yale-Brown-Cornell Eating Disorder Scale in women with anorexia nervosa: what is it measuring? International Journal of Eating Disorders 2008. Joyce PR. Classification of mood disorders in DSM-V and DSM-VI. Australian and New Zealand Journal of Psychiatry 2008; 42:851-862. Joyce PR. Best papers and improving impact factor for 2007. Aust N Z J Psychiatry. 2008 Nov;42(11):913-4. Kyle PM, Fielder JN, Pullar B, Horwood LJ, Moore MP. Comparison of methods to identify significant proteinuria in pregnancy in the outpatient setting. BJOG: An International Journal of Obstetrics and Gynaecology 2008; 115:523-527. Larkin G, Beautrais A. The epidemiology of emergency department visits for suicide attempts in the south pacific: New Zealand, 1997-2006. Annals of Emergency Medicine 2008; 51:554-555. Larkin G, Beautrais A, Gibb S, Laing S. The epidemiology of presentations for suicidal ideation to the emergency department. Academic Emergency Medicine 2008; 15:208-209. Larkin G, Smith R, Beautrais A. Trends in US Emergency Department visits for suicide attempts, 1992 - 2001. Crisis 2008; 29:73-80. Maguire S, le Grange D, Surgenor L, Marks P, Lacey H, Touyz S. Staging anorexia nervosa: conceptualising illness severity. Early Intervention in Psychiatry 2008; 2:3-10. Marie D, Fergusson D, Boden J. Educational achievment in Mäori: The roles of cultural identity and social disadvantage. Australian Journal of Education 2008; 52:183-196. Marie D, Fergusson D, Boden J. Ethnic identification, social disadvantage, and mental health in adolescence/young adulthood: Results of a 25-year longitudinal study. Australian and New Zealand Journal of Psychiatry 2008; 42:293-300. Marie D, Fergusson DM, Boden JM. Ethnic identity and intimate partner violence in a New Zealand birth cohort. Social Policy Journal of New Zealand 2008; 33:126-145. Marie D, Fergusson DM, Boden JM. Links between ethnic identification, cannabis use and dependence, and life outcomes in a New Zealand birth cohort. Aust N Z J Psychiatry 2008; 42:780-788. McHugh PC, Rogers GR, Loudon B, Glubb DM, Joyce PR, Kennedy MA. Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine. Journal of Neuroscience Research 2008; 86:306-316. McKinlay A, Grace R, Horwood L, Fergusson D, Ridder E, MacFarlane M. Prevalence of traumatic brain injury among children, adolescents, and young adults: prospective evidence from a birth cohort. Brain Injury 2008; 22:175-181. Mulder R, Frampton C, Luty S, Joyce P. Eighteen months of drug treatment for depression: Predicting relapse and recovery. Journal of Affective Disorders 2008. Mulder RT. An epidemic of depression or the medicalization of distress? Perspectives in Biology and Medicine 2008; 51:238-250. Mulder RT. Personality and depression: a commentary. Canadian Journal of Psychiatry 2008; 53:3-5. Mulder RT, Joyce PR, Frampton CM, Luty SE. Antidepressant treatment is associated with a reduction in suicidal ideation and suicide attempts. Acta Psychiatrica Scandinavia 2008:1-7. Nock MK, Borges G, Bromet EJ, Alonso J, Angermeyer M, Beautrais A, Bruffaerts R, Chiu WT, de Girolamo G, Gluzman S, de Graaf R, Gureje O, Haro JM, Huang Y, Karam E, Kessler RC, Lepine JP, Levinson D, Medina-Mora ME, Ono Y, Posada- Villa J, Williams D. Cross-national prevalence and risk factors for suicidal ideation, plans and attempts. British Journal of Psychiatry 2008; 192:98-105. Porter RJ, Booth D, Gray H, Frampton CMA. (2008). Effects of addition of remifentanil to propofol anaesthesia on seizure length and post ictal suppression index in electroconvulsive therapy. The Journal of ECT. 24(3):203-7. Porter R, Sellman J, Joyce P, Davies J, Frampton C. Prolactin response to fenfluramine in abstinent alcohol dependent patients. Addiction Biology 2008. Porter RJ, Douglas K, Knight RG. Monitoring of cognitive effects during a course of ECT: Recommendations for clinical practice. Journal of ECT 2008; 24:25-34. Porter RJ, Heenan H, Reeves J. Early effects of electroconvulsive therapy on cognitive function. The Journal of ECT 2008; 24:35-39. Porter RJ, Mulder RT, Joyce PR, Miller AL, Kennedy M. Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression. Journal of Affective Disorders 2008; 109:209-212. Rowe S, Jordan J, McIntosh VV, Carter FA, Bulik CM, Joyce PR. 2008. The impact of borderline personality disorder on bulimia nervosa. Australian and New Zealand Journal of Psychiatry. 42(12):10211029. Sanders J, Pithie A, Ganly P, Surgenor L, Wilson R, Merriman E, Loudon G, Rudkin R, Chambers S. (2008). A prospective double-blind randomised trial comparing intraluminal ethanol with heparinised saline for the prevention of catheter- associated blood stream infection in immunosuppressed patients. Journal of Antimicrobial Chemotherapy. 62(4):809-15.

Division of HEALTH SCIENCES 221 Snell D, Surgenor L, Hay-Smith J, Siegert R. A systematic review of psychological treatments for mild traumatic brain injury: an update on the evidence. Journal of Clinical and Experimental Gerontology 2008:1-19. Soh N, Touyz S, Dobbins T, Surgenor L, Clarke S, Kohn M, Lee E, Leow V, Rieger E, Ung K, Walter G. (2008). Cross-cultural differences in the macronutrient profiles of the diets of women with anorexia nervosa in Australia and Singapore. European Eating Disorders Review. 16(6):427-35. Soh N, Touyz S, Dobbins T, Surgenor L, Clarke S, Kohn M, Leow V, Rieger E, Ung K, Walter G. Body image disturbance in young Northern European and East Asian women with and without eating disorders in Australia and Singapore. European Eating Disorders Review 2008; 16:287-296. Stuffrein-Roberts S, Joyce PR, Kennedy MA. Role of epigenetics in mental disorders. Australian and New Zealand Journal of Psychiatry 2008; 42:97-107. Wilson B, Crowe M. (2008). Maintaining equilibrium: a theory of job satisfaction for community mental health nurses. Journal of Psychiatric and Mental Health Nursing. 15(10):816-22.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF PUBLIC HEALTH AND GENERAL PRACTICE, UOC

Chapter in Book – Research Barnett, R. & Barnett, P. (2008). Reinventing Primary Care: The New Zealand Case Compared. In V.A. Crooks & G.J. Andrews (Eds.), Primary Health Care: People, Practice, Place (pp. 149-165). London, Ashgate Press. Heeringa, S.G., Wells, J.E., Hubbard, F., Mneimneh, Z.N., Chiu, W.T., Sampson, N.A,, Berglund, P.A. (2008) Sample designs and sampling procedures. In R.C. Kessler & T.B. Ustun (Eds.), The Epidemiology of Mental Disorders: Global Perspectives from the WMH World Mental Health Surveys (pp. 14-32). Cambridge, Cambridge University Press. Oakley-Browne, M.A., Wells, J.E., Scott, K.M. (2008). Te Rau Hinengaro: The New Zealand Mental Health Survey. In R.C. Kessler & T.B. Ustun (Eds.), The Epidemiology of Mental Disorders: Global Perspectives from the WMH World Mental Health Surveys (pp. 486-508). Cambridge, Cambridge University Press. Pennell, B-E., Mneimneh, Z.N., Bowers, A., Chardoul, S., Wells, J.E., Viana, M.C., Dinkelmann, K., Gebler, N., Florescu, S., He, Y., Huang, Y., Tomov, T., Vilagut, G. (2008). In R.C. Kessler and T.B. Ustun (Eds.), The Epidemiology of Mental Disorders: Global Perspectives from the WMH World Mental Health Surveys (pp. 33-57). Cambridge, Cambridge University Press. Wang, P.S., Aguilar-Gaxiola, S., Alonso,. J., Angermeyer, M.C., Borges, G., Bromet, E.J., Bruffaerts, R., Chatterji, S., de Girolamo, G., de Graaf, R., Gureje, O., Haro, J.M., Heeringa, S.G., Karam, E.G., Kessler, R.C., Kovess-Masfety, V., Lane, M.C., Lee, S., Levinson, D., Ono, Y., Pennell, B-E., Petukhova, M., Posada-Villa, J., Saunders, K., Seedat, S., Shen, Y., Ustun, T.B., Wells, J.E. (2008) Recent treatment of mental disorders in the World Mental Health Survey Initiative. In R.C. Kessler and T.B. Ustun (Eds.), The Epidemiology of Mental Disorders: Global Perspectives from the WMH World Mental Health Surveys (pp. 541-552). Cambridge, Cambridge University Press.

Journal – Research Article Abel, G. & Fitzgerald, L. (2008). On a fast-track into adulthood: An exploration of transitions into adulthood for street-based sex workers in New Zealand. Journal of Youth Studies, 11(4), 361-376. Anderson, N.G., Notley, E., Graham, P., McEwing, R. (2008). Reproducibility of sonographic assessment of fetal liver in diabetic pregnancies. Ultrasound in Obstetrics and Gynecology, 31: 529-534. Ashton, T., Tenbensel, T., Cumming, J., & Barnett, P. (2008). Decentralizing resource allocation: early experiences with District Health Boards in New Zealand. Journal of Health Services Research and Policy, 13(2): 109-115. Barnett, P., Penny, M., Brunton, C. & Begg, A. (2008). Dispatches from the front-line: An analysis of fluoridation campaigns in southern New Zealand, 2002-2006. New Zealand Dental Journal, 104(4): 139-143. Degenhardt, L., Chiu, W. T., Sampson, N., Kessler, R. C., Anthony, J. C., Angermeyer, M., Bruffaerts, R., de Girolamo, G., Gureje, O., Huang, Y., Karam, A., Kostyuchenko, S., Lepine, J. P., Medina Mora, M. E., Neumark, Y., Ormel, J., Pinto-Meza, A., Posada-Villa, J., Stein, D. J., Takeshima, T., Wells, J. E. (2008). Toward a global view of alcohol, tobacco, cannabis, and cocaine use: Findings from the WHO World Mental Health Surveys. PLoS Medicine. 5, e141 doi:110.1371/journal. pmed.0050141. Duffy, S.W., Nagtegaal, I.D., Astley, S.M., Gillan, M.G.C., McGee, M.A., Boggis, C.R.M., Wilson, M., Beetles, U.M., Griffiths, M.A., Jain, A.K, Johnson, J., Roberts, R., Deans, H., Duncan, K.A., Iyengar, G., Griffiths, P.M., Warwick, J., Cuzick, J., Gilbert, F.J. Visually assessed breast density, breast cancer risk and the importance of the craniocaudal view. Breast Cancer Research, 10:R64. Gee, P., Gilbert, M., Richardson, S., Moore, G., Paterson, S. & Graham, P. (2008). Toxicity from the recreational use of 1-benzylpiperazine. Clinical Toxicology, 46(a), pp 802-807. Gilbert, F.J., Astley, S.M, Boggis, C.R.M., McGee, M.A., Griffiths, P.M., Duffy, S.W., Agbaje, O.F., Gillan, M.G.C., Wilson, M., Jain, A.K., Barr, N., Beetles, U.M., Griffiths, M.A., Johnson, J., Roberts, R.M., Deans, H.E., Duncan, K.A., Iyengar, G. (2008). Variable size computer-aided detection prompts and mammography film reader decisions. Breast Cancer Research,10:R72.

222 RESEARCH REPORT 2007/2008 Graham P., Young, J., Penny, R., (2008) Methods for creating synthetic data. Official Statistics Research Series, 3, [online], available www.statisphere.govt.nz/osresearch Graham, P. (2008) Intelligent smoothing using hierarchical Bayesian models. Epidemiology, 19:493-495. Scott, K., McGee, M.A., Schaaf, D., Baxter, J. (2008) Mental-physical comorbidity in an ethnically diverse population. Social Science & Medicine, 66: 1165-1173. Scott, K.M., McGee, M.A., Wells, J.E., Oakley Browne, M.A. (2008). Obesity and mental disorders in the adult general population. Journal of Psychosomatic Research, 64: 97-105. Sykes, P. H., Harker, D. Y., Miller, A. M. W., Neal, H., Wells, J. E., Peddie, D. A randomised comparison of SurePath liquid- based cytology and conventional smear cytology in a colposcopy clinic setting. (2008). BJOG: An International Journal of Obstetrics & Gynaecology, 115: 1375-1381. Tenbensel, T., Cumming, J., Ashton, T. & Barnett, P. (2008). Where there’s a will, is there a way?: Is New Zealand’s publicly funded health sector able to steer towards population health? Social Science and Medicine, 67: 1143-1152. Vitry, A., Lexchin, J., Sasich, L., Dupin-Spriet, T., Reed, T., Bertele, V., Garattini, S.,Toop, L., & Hurley, E. (2008). Provision of information on regulatory authorities’ websites. Internal Medicine Journal, 38(7) 559-67. Walker, L.C., Harris, G.C., Wells, J.E., Robinson, B.A., Morris, C.M. (2008). Association of chromosome band 8q22 copy number gain with high grade invasive breast carcinomas by assessment of core needle biopsies. Genes, Chromosomes & Cancer, 47: 405-417. Wells, J.E., McGee, M.A. (2008). Violations of the usual sequence of drug initiation: prevalence and associations with the development of dependence in the New Zealand Mental Health Survey. Journal of Studies on Alcohol and Drugs, 69: 789-795.

Journal – Research Other Malcolm, L. & Barnett, P. (2008). Health services research: an essential part of a wider spectrum of national health information? New Zealand Medical Journal, vol 121 no 1272.

Journal – Professional & Other Non-Research Articles Sheerin, I. (2008). How do walnuts compare with conventional medicines for controlling cholesterol? Health in a Shell, 70, 3-7.

Commissioned Report for External Body Slack, A., O’Dea, D., Sheerin, I., Norman, D., Wu, J. & Nana, G. (2008) New Zealand Drug Harm Index. Report for the New Zealand Police commissioned by Business and Economic Research Limited. Wellington, 85p.

UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF RADIOLOGY

Journal – Research Article Anderson NG, Notley E, Graham P, McEwing R. Reproducibility of sonographic assessment of fetal liver length in diabetic pregnancies. Ultrasound Obstet Gynecol. 2008; 31(5): 529-34. Buckenham T. Computed tomography angiographic imaging of the long saphenous vein: diagnostic overkill or a useful advance? ANZ J Surg. 2008; 78(7): 619. Butler APH, Anderson NG, Tipples R, Cook N, Watts R, Meyer J, Bell AJ, Melzer TR, Butler PH. Bio-medical X-ray imaging with spectroscopic pixel detectors. Nuclear Instruments and Methods in Physics Research A. 2008; 591(1): 141-6. Butler A, Bones P, Hurrell M. Prototype system for enhancement of frontal chest radiographs using eigenimage processing. J Med Imaging Radiat Oncol. 2008; 52(3): 244-53. Day CP, Buckenham TM. Outcomes of Endovascular Repair of Acute Thoracic Aortic Injury: Interrogation of the New Zealand Thoracic Aortic Stent Database (NZ TAS). Eur J Vasc Endovasc Surg. 2008; 36(5): 530-534. Day CP, Buckenham TM. Endovascular Repair of the Thoracic Aorta: Predictors of 30-Day Mortality in Patients on the New Zealand Thoracic Aortic Stent Database (NZ TAS). Eur J Vasc Endovasc Surg. 2008 Nov 12. Epub ahead of print. Carter K, Roake JA, Buckenham T, Frampton CM, Lewis DR. Informed consent for vascular intervention: completing one audit loop. N Z Med J. 2008; 121(1269): 57-63. Hutchinson CD, Jardine DL, Hurrell M. Vagolysis. Age Ageing. 2008; 37 (5): 602-604. Mitchell DM, Wynne CJ, Cowan I. Multiple cranial nerve palsies as the presenting features of prostate carcinoma. J Med Imaging Radiat Oncol. 2008; 52(2): 194-6. Oram BJ, Buckenham TM, Roake JA, Lewis DR. Treatment delays for patients exiting an aortic aneurysm surveillance programme. ANZ J Surg. 2008; 78(3): 148-50. Yong D, Roake JA, Buckenham T, Lewis DR. Endovascular repair of mycotic aortic aneurysms. NZ Med J. 2008; 121(1269): 64-7.

Division of HEALTH SCIENCES 223 UNIVERSITY OF OTAGO, CHRISTCHURCH DEPARTMENT OF SURGERY

Chapter in Book Beasley SW. Chylothorax. In: Paediatric Surgery: diagnosis and management. Ed: Gupta DK, Jaypee Brothers Medical Publishers, New Delhi, 2009, pp 491-494.

Journal – Research Article Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, Hewett PJ, Rieger NA, Smith S, Solomon MJ, Stevenson AR. Australian and New Zealand study comparing laparoscopic and open surgeries for colon cancer in adults: organization and conduct. ANZ J Surg. 2008 Oct;78(10):840-7. Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, Hewett PJ, Rieger NA, Smith S, Solomon MJ, Stevenson AR. The Australasian laparaoscopic colon cancer study. ANZ J Surg. 2008 Oct;78(10):832-3. Azzie G, Bickler S, Farmer D, Beasley S. Partnerships for developing pediatric surgical care in low-income countries. J Pediatr Surg. 2008 Dec;43(12):2273-4. Allardyce R A, Bagshaw P F, Frampton C M, Frizelle F A, Hewett PJ , Rieger N A, Smith S, Solomon M J, Stevenson ARL for the Australasian Laparoscopic Colon Cancer Study (ALCCaS) Group. Perspective; The Australasian Laparaoscopic Colon Cancer Study (ALCCaS) ANZJS 2008; 78, 832-833. Beasley SW . Changing face of rural paediatric surgery – Perspective. ANZJS 2008; 78: 632-633. Beasley SW. Monopolar diathermy dissection made easy.ANZ J Surg. 2008 Dec;78(12):1119-21. Bentley RW, Keenan JI, Gearry RB, Kennedy MA, Barclay ML, Roberts RL. Incidence of Mycobacterium avium subspecies paratuberculosis in a population-based cohort of patients with Crohn’s disease and control subjects. Am J Gastroenterol. 2008 May;103(5):1168-72. Bird P A., Begg E J., Rapid Clearance of Methylprednisolone After Intratympanic Application in Humans: In Reply Otology & Neurotology, 2008, 29 (5):733. Bird P A, Murray D. Cochlear Implantation: a panacea for severe hearing loss? The New Zealand Medical Journal, 2008. 121:1280. Bruijnen CJ, Vogels HD, Beasley SW. Review of the extent to which orchidopexy is performed at the optimal age: implications for health services. ANZ J Surg. 2008 Nov;78(11):1006-9. Carter K, Roake JA, Buckenham T, Frampton CM, Lewis DR. Informed consent for vascular intervention: completing one audit loop. N Z Med J. 2008 Feb 15;121(1269):57-63. Chitcholtan K, Hampton MB, Keenan JI. Outer membrane vesicles enhance the carcinogenic potential of Helicobacter pylori. Carcinogenesis. 2008 Dec;29(12):2400-5. Connor SJ, Lienert AR, Brown LA, Bagshaw PF. Closing the audit loop is necessary to achieve compliance with evidence-based guidelines in the management of acute pancreatitis. N Z Med J. 2008 Jun 6;121(1275):19-25. Darlow BA, Elder MJ, Horwood LJ, Donoghue DA, Henderson-Smart DJ; Australian and New Zealand Neonatal Network. Does observer bias contribute to variations in the rate of retinopathy of prematurity between centres? Clin Experiment Ophthalmol. 2008 Jan-Feb;36(1):43-6. Firth CA, Crone EM, Flavall EA, Roake JA, Gieseg SP. Macrophage mediated protein hydroperoxide formation and lipid oxidation in low density lipoprotein are inhibited by the inflammation marker 7,8-dihydroneopterin. Biochim Biophys Acta. 2008 Jun;1783(6):1095-101. Frizelle FA. Resourcing for the growing burden of elderly patients with cancer. ANZ J Surg. 2008 Jun;78(6):428-9. Heriot AG, Byrne CM, Lee P, Dobbs B, Tilney H, Solomon MJ, Mackay J, Frizelle F. Extended radical resection: the choice for locally recurrent rectal cancer. Dis Colon Rectum. 2008 Mar;51(3):284-9. Hewett PJ, Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, Rieger NA, Smith JS, Solomon MJ, Stephens JH, Stevenson AR. Short-term outcomes of the Australasian randomized clinical study comparing laparoscopic and conventional open surgical treatments for colon cancer: the ALCCaS trial. Ann Surg. 2008 Nov;248(5):728-38. 105-8. Horrocks E, Roake J, Lewis D. Best practice for assessment of patients with varicose veins. N Z Med J. 2008 May 23;121(1274):42-9. Ing A, Lienert A, Frizelle F. Medical image. CT colonography for colovesical fistula. N Z Med J. 2008 Aug 8;121(1279). Keenan JI, Beaugie CR, Jasmann B, Potter HC, Collett JA, Frizelle FA. Helicobacter species in the human colon. Colorectal Dis. 2008 Aug 21. [Epub ahead of print]. Keenan JI, Davis KA, Beaugie CR, McGovern JJ, Moran AP. Alterations in Helicobacter pylori outer membrane and outer membrane vesicle-associated lipopolysaccharides under iron-limiting growth conditions. Innate Immun. 2008 Oct;14(5):279-90. Lee PJ, Raniga S, Biyani DK, Watson AJ, Faragher IG, Frizelle FA. Sacrococcygeal pilonidal disease. Colorectal Dis. 2008 Sep;10(7):639-50; discussion 651-2. Moorhead KT, Lee D, Chase JG, Moot AR, Ledingham KM, Scotter J, Allardyce RA, Senthilmohan ST, Endre Z. Classifying algorithms for SIFT-MS technology and medical diagnosis. Comput Methods Programs Biomed. 2008 Mar;89(3):226-38. Munday JS, Frizelle FA, Whitehead MR. Mismatch repair protein expression in ovine intestinal adenocarcinomas. Vet Pathol. 2008 Jan;45(1):3-6.

224 RESEARCH REPORT 2007/2008 Oram BJ, Buckenham TM, Roake JA, Lewis DR. Treatment delays for patients exiting an aortic aneurysm surveillance programme. ANZ J Surg. 2008 Mar;78(3):148-50. Paddison JS, Booth RJ, Cameron LD, Robinson E, Frizelle FA, Hill AG. Fatigue after colorectal surgery and its relationship to patient expectations. J Surg Res. 2009 Jan;151(1):145-52. Pick ZS, Leaming DV, Elder MJ. The fourth New Zealand cataract and refractive surgery survey: 2007. Clin Experiment Ophthalmol. 2008 Oct;36(7):604-19. Pick ZS, Stewart J, Elder MJ. The New Zealand ophthalmology workforce 2008. Clin Experiment Ophthalmol. 2008 Nov;36(8):762-6. Piuhola J, Kerkelä R, Keenan JI, Hampton MB, Richards AM, Pemberton CJ. Direct cardiac actions of erythropoietin (EPO): effects on cardiac contractility, BNP secretion and ischaemia/reperfusion injury. Clin Sci (Lond). 2008 Feb;114(4):293-304. Renaut AJ, Raniga S, Frizelle FA, Perry RE, Guilford L. A randomized controlled trial comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy. Colorectal Dis. 2008 Jun;10(5):503-5. Roake JA. Liver transplantation in Australia and New Zealand. ANZ J Surg. 2008 Aug;78(8):628-9. Scarlett, Bird P, MacFarlane M. Conductive Hearing Loss Following Retrosigmoid Excision of Acoustic Neuroma Otology & Neurotology, 2008 29:553-556. Simcock JW, Penington AJ, Morrison WA, Thompson EW, Mitchell GM. Endothelial Precursor Cells Home to a Vascularized Tissue Engineering Chamber by Application of the Angiogenic Chemokine CXCL12. Tissue Eng Part A. 2008 Dec 6. [Epub ahead of print]. Sutherland AD, Faragher IG, Frizelle FA. Intradermal injection of methylene blue for the treatment of refractory pruritus ani. Colorectal Dis. 2008 May 29. [Epub ahead of print] Sutherland AD, Gearry RB, Frizelle FA. Review of fecal biomarkers in inflammatory bowel disease. Dis Colon Rectum. 2008 Aug;51(8):1283-91. Wakeman CJ, Dobbs BR, Frizelle FA, Bissett IP, Dennett ER, Hill AG, Thompson-Fawcett MW. The impact of splenectomy on outcome after resection for colorectal cancer: a multicenter, nested, paired cohort study. Dis Colon Rectum. 2008 Feb;51(2):213-7. Wickramaratne H & Beasley SW. Legionnaire’s disease and the risk of burns in children. NZ Med. J. 2008; 121 (1267): 2911. Wood VH, Bird P, Giles EC, Baber WJ Unsuccessful Cochlear Implantation in Two Patients with Superficial Siderosis of the Central Nervous System Otology & Neurotology, 2008. 29 (5):622-625. Yong D, Roake JA, Buckenham T, Lewis DR. Endovascular repair of mycotic aortic aneurysms. N Z Med J. 2008 Feb 15;121(1269):64-7. Young SC, Solomon MJ, Hruby G, Frizelle FA. Review of 120 anal cancer patients. Colorectal Dis. 2008 Oct 25. [Epub ahead of print].

Journal – Other Beasley SW. Incomplete understanding of incomplete descent. ANZ J Surg. 2008 Nov;78(11):937. Beasley SW. Changing face of rural paediatric surgery. ANZ J Surg. 2008 Aug;78(8):632-3. Frizelle FA. Defamatory articles or not? N Z Med J. 2008 Aug 8;121(1279):16-7. Frizelle FA. What are the major political parties’ healthcare policies for New Zealand? N Z Med J. 2008 Oct 3;121(1283):12-4. McBride CA, Beasley SW. Morgagni’s hernia: believing is seeing. ANZ J Surg. 2008 Sep;78(9):739-44. Roake J. Academic surgery in New Zealand: dodo or phoenix? ANZ J Surg. 2008 May;78(5):343-4.

UNIVERSITY OF OTAGO, CHRISTCHURCH CENTRE FOR POSTGRADUATE STUDIES IN NURSING

Journal – Research Article Bennett, J, Brown, P., Cameron, L., Whitehead, L., Porter, D., & McPherson, K.M. (2008). Changes in employment and household income during the 24 months following a cancer diagnosis. Supportive Care in Cancer, Nov 27. Epub ahead of print. Conder, J., Mirfin-Veitch, B. (2008). Giving and receiving personal care – what does it mean for clients and carers? Kai Tiaki Nursing New Zealand, 14(10), 20-22. Dawson S.I., Willis J., Florkowski C.M., Scott R.S. (2008) Cause-specific mortality in insulin-treated diabetic patients: A 20- year follow-up. Diabetes Research and Clinical Practice. 80(1; 16-23. Dawson S.I., Willis J., Florkowski C.M., Scott R.S. (2008) All-cause mortality in insulin-treated diabetic patients: A 20-year follow-up. Diabetes Research and Clinical Practice. 80(1); e6-e9. Munford, R., Sanders, J., Mirfin-Veitch, M., Conder, J. (2008). Ethics and Research: Searching for ethical practice in research. Ethics and Social Welfare, 2(1), 50-66. Munford, R., Sanders, J., Mirfin-Veitch, M., Conder, J. (2008). Looking inside the bag of tools: Creating research encounters with parents with an intellectual disability. Disability & Society, 23(4), 337-347.

Division of HEALTH SCIENCES 225 UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF MEDICINE

Journal – Research Article Asher MI, Stewart AW, Clayton T, Crane J, Ellwood PI, Mackay R, Mitchell E, Moyes C, Pattemore PK, Pearce N. Has the prevalence and severity of symptoms of asthma changed among children in New Zealand? ISAAC Phase Three. N Z Med J. 2008 Oct 17;121(1284):52-63. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and risk of lung cancer: a case-control study. Eur Respir J. 2008 Feb;31(2):280-6. Aldington S, Williams M, Nowitz M, Weatherall M, Pritchard A, McNaughton A, Robinson G, Beasley R. Effects of cannabis on pulmonary structure, function and symptoms. Thorax. 2007 Dec;62(12):1058-63. Epub 2007 Jul 31. Erratum in: Thorax. 2008 Apr;63(4):385. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and cancer of the head and neck: case-control study. Otolaryngol Head Neck Surg. 2008 Mar;138(3):374-80. Beasley R, Bibby S, Weatherall M. Leukotriene receptor antagonist therapy and Churg-Strauss syndrome: culprit or innocent bystander? Thorax. 2008 Oct;63(10):847-9. Bridgman PG, Ashrafi AN, Mann S, Whalley GA; SCANZ collaborators. Survey of clinical echocardiography in New Zealand (SCANZ). N Z Med J. 2008 Feb 5;121(1269):34-44. Bush A, Burgess C. (2008). Fatal cardiomyopathy due to quetiapine. New Zealand Medical Journal. 121(1268):U2909. Beasley R, Clayton T, Crane J, von Mutius E, Lai CK, Montefort S, Stewart A; ISAAC Phase Three Study Group. Association between paracetamol use in infancy and childhood, and risk of asthma, rhinoconjunctivitis, and eczema in children aged 6-7 years: analysis from Phase Three of the ISAAC programme. Lancet. 2008 Sep 20;372(9643):1039-48. Causer SM, Shorter CL, Lewis RD, Siebers RW. Efficiency of vacuuming for the removal of cat allergen (Fel d 1) from worn and unworn wool carpets of different construction. Textile Research Journal 2008; 78: 105-110. Chan WC, Wright C Mr, Tobias M Dr, Mann S, Jackson RT. Explaining trends in coronary heart disease hospitalisations in New Zealand: Admissions and incidence can trend in opposite directions. Heart. 2008 Jun 2. [Epub ahead of print] Copeland JM, Taylor WJ, Dean SG. Factors Influencing the Use of Outcome Measures for Patients With Low Back Pain: A Survey of New Zealand Physical Therapists. Phys Ther. 2008 Oct 10. [Epub ahead of print]. Donovan K, Lord SE, McNaughton HK, Weatherall M. Mobility beyond the clinic: the effect of environment on gait and its measurement in community-ambulant stroke survivors. Clin Rehabil. 2008 Jun;22(6):556-63. Ferrier KA, Neill AM, O’Meeghan T, Richards M, Campbell AJ. Continuous positive airway pressure in heart failure patients with obstructive sleep apnoea. Intern Med J. 2008 Feb 14. [Epub ahead of print] Gehring U, Strikwold M, Schram-Bijkerk D, Weinmayr G, Genuneit J, Nagel G, Wickens K, Siebers R, Crane J, Doekes G, Di Domenicantonio R, Nilsson L, Priftanji A, Sandin A, El-Sharif N, Strachan D, van Hage M, von Mutius E, Brunekreef B; and the ISAAC Phase Two Study Group. Asthma and allergic symptoms in relation to house dust endotoxin: Phase Two of the International Study on Asthma and Allergies in Childhood (ISAAC II). Clin Exp Allergy. 2008 Sep 3 epub. Hay-Smith J, Mørkved S, Fairbrother KA, Herbison GP. Pelvic floor muscle training for prevention and treatment of urinary and faecal incontinence in antenatal and postnatal women. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD007471. Helliwell PS, Taylor WJ; CASPAR Study Group. Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs – comparison of drugs and adverse reactions. J Rheumatol. 2008 Mar;35(3):472-6. Epub 2008 Jan 15. Hollis-Moffatt JE, Merriman ME, Rodger RA, Rowley KA, Chapman PT, Dalbeth N, Gow PJ, Harrison AA, Highton J, Jones PB, O’Donnell JL, Stamp LK, Merriman TR. Evidence for association of an interleukin-23 receptor variant independent of the R381Q variant with rheumatoid arthritis. Ann Rheum Dis. 2008 Jul 22. [Epub ahead of print] Howden-Chapman P, Pierse N, Nicholls S, Gillespie-Bennett J, Viggers H, Cunningham M, Phipps R, Boulic M, Fjallstrom P, Free S, Chapman R, Lloyd B, Wickens K, Shields D, Baker M, Cunningham C, Woodward A, Bullen C, Crane J. Effects of improved home heating on asthma in community dwelling children: randomised controlled trial. BMJ. 2008 Sep 23;337. Lauti M, Herbison P, Hay-Smith J, Ellis G, Wilson D. Anticholinergic drugs, bladder retraining and their combination for urge urinary incontinence: a pilot randomised trial. Int Urogynecol J Pelvic Floor Dysfunct. 2008 Nov;19(11):1533-43. Lord S, McPherson KM, McNaughton HK, Rochester L, Weatherall M. How feasible is the attainment of community ambulation after stroke? A pilot randomized controlled trial to evaluate community-based physiotherapy in subacute stroke. Clin Rehabil. 2008 Mar;22(3):215-25. Mahony PH, Griffiths RF, Larsen P, Powell D. Retention of knowledge and skills in first aid and resuscitation by airline cabin crew. Resuscitation. 2008 Mar;76(3):413-8. Mann S, Lehman R. Atrial fibrillation and warfarin. Response. Evid Based Med. 2008 Feb;13(1):29. Marsh SE, Travers J, Weatherall M, Williams MV, Aldington S, Shirtcliffe PM, Hansell AL, Nowitz MR, McNaughton AA, Soriano JB, Beasley RW. Proportional classifications of COPD phenotypes. Thorax. 2008 Sep;63(9):761-7. Marshall NS, Neill AM, Campbell AJ. Randomised trial of compliance with flexible (C-Flex) and standard continuous positive airway pressure for severe obstructive sleep apnea. Sleep Breath. 2008 Nov;12(4):393-6. Epub 2008 May 31.

226 RESEARCH REPORT 2007/2008 McKinney C, Merriman ME, Chapman PT, Gow PJ, Harrison AA, Highton J, Jones PB, McLean L, O’Donnell JL, Pokorny V, Spellerberg M, Stamp LK, Willis J, Steer S, Merriman TR. Evidence for an influence of chemokine ligand 3-like 1 (CCL3L1) gene copy number on susceptibility to rheumatoid arthritis. Ann Rheum Dis. 2008. 67(3):409-13. Nam HS, Siebers R, Lee SH, Park JS, Kim YB, Choi YJ, Lee SH, Crane J. House dust mite allergens in domestic homes from Cheonan, Korea. Korean Journal of Parasitology 2008; 46: 187-189. Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J; Probiotic Study Group. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008 Oct;38(10):1606-14. Ritchlin CT, Kavanaugh A, Gladman DD, Mease PJ, Helliwell P, Boehncke WH, de Vlam K, Fiorentino D, Fitzgerald O, Gottlieb AB, McHugh N, Nash PT, Qureshi A, Soriano ER, Taylor WJ. Treatment recommendations for psoriatic arthritis. Ann Rheum Dis. 2008 Oct 24. [Epub ahead of print]. Sapre N, Mann S, Elley CR. Doctors’ perceptions of the prognostic benefit of statins in patients who have had myocardial infarction. Intern Med J. 2008 Jun 28. [Epub ahead of print] Siegert RJ, Weatherall M, Bell EM. Is implicit sequence learning impaired in schizophrenia? A meta-analysis. Brain Cogn. 2008 Aug;67(3):351-9. Epub 2008 Apr 18. Siegert RJ, Weatherall M, Taylor KD, Abernethy DA. A meta-analysis of performance on simple span and more complex working memory tasks in Parkinson’s disease. Neuropsychology. 2008 Jul;22(4):450-61. Taylor WJ. Sensitivity and Specificity of the CASPAR Criteria for Psoriatic Arthritis in a Family Medicine Clinic Setting: Dr. Taylor replies. J Rheumatol. 2008 Oct;35(10):2070. Taylor WJ, Harrison AA, Highton J, Chapman P, Stamp L, Dockerty J, McQueen F, Jones PB, Ching D, Porter D, Rajapakse C, Rudge SR, Taylor G, Kumar S, Macedo T, Hoy MS. Disease Activity Score 28-ESR bears a similar relationship to treatment decisions across different rheumatologists, but misclassification is too frequent to replace physician judgement. Rheumatology (Oxford). 2008 Apr;47(4):514-8. Epub 2008 Mar 5. Taylor WJ, Colvine K, Gregory K, Collis J, McQueen FM, Dalbeth N. The Health Assessment Questionnaire Disability Index is a valid measure of physical function in gout. Clin Exp Rheumatol. 2008 Jul-Aug;26(4):620-6. Taylor WJ, Helliwell PS. Psoriatic arthritis is a joint-damaging disease--a call for action! Rheumatology (Oxford). 2007 Dec;46(12):1747-8. Taylor WJ, Korendowych E, Nash P, Helliwell PS, Choy E, Krueger GG, Soriano ER, McHugh NJ, Rosen CF. Drug use and toxicity in psoriatic disease: focus on methotrexate. J Rheumatol. 2008 Jul;35(7):1454-7. Taylor WJ, Schumacher HR Jr, Baraf HS, Chapman P, Stamp L, Doherty M, McQueen F, Dalbeth N, Schlesinger N, Furst DE, Mellado JV, Becker MA, Kavanaugh A, Louthrenoo W, Bardin T, Khanna D, Simon LS, Yamanaka H, Choi HK, Zeng X, Strand V, Grainger R, Clegg D, Singh JA, Diaz-Torne C, Boers M, Gow P, Barskova VG. A modified Delphi exercise to determine the extent of consensus with OMERACT outcome domains for studies of acute and chronic gout. Ann Rheum Dis. 2008 Jun;67(6):888-91. Tobias M, Taylor R, Yeh LC, Huang K, Mann S, Sharpe N. Did it fall or was it pushed? The contribution of trends in established risk factors to the decline in premature coronary heart disease mortality in New Zealand. Aust N Z J Public Health. 2008 Apr;32(2):117-25. Tobias M, Chan WC, Wright C, Jackson R, Mann S, Yeh LC. Can the incidence and prevalence of coronary heart disease be determined from routinely collected national data? Population-based estimates for New Zealand in 2001--03. Aust N Z J Public Health. 2008 Feb;32(1):24-7. Tweed M, Wilkinson T. A randomized controlled trial comparing instructions regarding unsafe response options in a MCQ examination. Med Teach. 2008 Sep 29:1-4. [Epub ahead of print] Weatherall M, James K, Clay J, Perrin K, Masoli M, Wijesinghe M, Beasley R. Dose-response relationship for risk of non- vertebral fracture with inhaled corticosteroids. Clin Exp Allergy. 2008 Sep;38(9):1451-8. West J, Perrin K, Aldington S, Weatherall M, Beasley R. A case-control study of seated immobility at work as a risk factor for venous thromboembolism. J R Soc Med. 2008 May;101(5):237-43. Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J; Probiotic Study Group. A differential effect of 2 probiotics in the prevention of eczema and atopy: A double-blind, randomized, placebo-controlled trial.J Allergy Clin Immunol. 2008 Aug 31 epub. Wickens K, Ingham T, Epton M, Pattemore P, Town I, Fishwick D, Crane J; New Zealand Asthma and Allergy Cohort Study Group. The association of early life exposure to antibiotics and the development of asthma, eczema and atopy in a birth cohort: confounding or causality? Clin Exp Allergy. 2008 Aug;38(8):1318-24. Wijesinghe M, Perrin K, Harwood M, Weatherall M, Beasley R. The risk of asthma mortality with inhaled long acting beta- agonists.Postgrad Med J. 2008 Sep;84(995):467-72. Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Weatherall M, Beasley R.The routine use of oxygen in the treatment of myocardial infarction: systematic review. Heart. 2008 Aug 15. [Epub ahead of print]

Division of HEALTH SCIENCES 227 Major Review Dumoulin C, Hay-Smith J. Pelvic floor muscle training versus no treatment for urinary incontinence in women. A Cochrane systematic review. Eur J Phys Rehabil Med. 2008 Mar;44(1):47-63. Grainger R, Taylor WJ. Establishing outcome domains for evaluating treatment of acute and chronic gout. Curr Opin Rheumatol. 2008 Mar;20(2):173-8. Taylor WJ, Schumacher HR Jr, Singh JA, Grainger R, Dalbeth N.Assessment of outcome in clinical trials of gout – a review of current measures. Rheumatology (Oxford). 2007 Dec;46(12):1751-6. Epub 2007 Jul 24.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF OBSTETRICS AND GYNAECOLOGY

Journal – Research Article Aoba T, Kitagawa H, Pringle KC, Koike J, Nagae H, Zuccollo J, Shimada J, Seki Y. Can a pressure-limited vesico-amniotic shunt tube preserve normal bladder function? J Pediatr Surg. 2008 Dec;43(12):2250-5. Omori S, Kitagawa H, Koike J, Fujita H, Hida M, Pringle KC, Awazu M. Activated extracellular signal-regulated kinase correlates with cyst formation and transforming growth factor-beta expression in fetal obstructive uropathy. Kidney Int. 2008 May;73(9):1031-7. Wong HS, Cheung YK, Zuccollo J, Tait J, Pringle KC. Evaluation of sonographic diagnostic criteria for placenta accreta. J Clin Ultrasound. 2008 Nov-Dec;36(9):551-9. Wong A, Elder D, Zuccollo J. Changes in cause of neonatal death over a decade. N Z Med J. 2008 Jul 4;121(1277):39-46. Wong HS, Hutton J, Zuccollo J, Tait J, Pringle KC. The maternal outcome in placenta accreta: the significance of antenatal diagnosis and non-separation of placenta at delivery. N Z Med J. 2008 Jul 4;121(1277):30-8. Wong HS, Kidd A, Zuccollo J, Tuohy J, Strand L, Tait J, Pringle KC. A case of thanatophoric dysplasia: the early prenatal 2D and 3D sonographic findings and molecular confirmation of diagnosis. Fetal Diagn Ther. 2008;24(1):71-3. Wong HS, Parker S, Tait J, Pringle KC. Antenatal diagnosis of anophthalmia by three-dimensional ultrasound: a novel application of the reverse face view. Ultrasound Obstet Gynecol. 2008 Jul;32(1):103-5. Wong HS, Tait J, Pringle KC. Viewing of the soft and the hard palate on routine 3-D ultrasound sweep of the fetal face--a feasibility study. Fetal Diagn Ther. 2008;24(2):146-54. Wong HS, Zuccollo J, Tait J, Pringle K. Antenatal topographical assessment of placenta accreta with ultrasound. Aust N Z J Obstet Gynaecol. 2008 Aug;48(4):421-3.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF PAEDIATRICS AND CHILD HEALTH

Journal – Research Article Bergin PS, Sadleir LG, Walker EB. Bringing epilepsy out of the shadows in New Zealand. N Z Med J. 2008 Jan 25;121(1268):U2894. Review. Gleeson H, Wiltshire E, Briody J, Hall J, Chaitow J, Sillence D, Cowell C, Munns C. Childhood chronic recurrent multifocal osteomyelitis: pamidronate therapy decreases pain and improves vertebral shape. J Rheumatol. 2008 Apr;35(4):707-12 Mackenzie KE, Wiltshire EJ, Peña AS, Gent R, Hirte C, Piotto L, Couper JJ. Hs-CRP is associated with weight, BMI, and female sex but not with endothelial function in children with type 1 diabetes.Pediatr Diabetes. 2008 Sep 15. Epub ahead of print. Prescott SL, Wickens K, Westcott L, Jung W, Currie H, Black PN, Stanley TV, Mitchell EA, Fitzharris P, Siebers R, Wu L, Crane J; Probiotic Study Group. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008 Oct;38(10):1606-14. Sadleir LG, Scheffer IE, Smith S, Carstensen B, Carlin J, Connolly MB, Farrell K. Factors influencing clinical features of absence seizures. Epilepsia. 2008 Dec;49(12):2100-7. Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J; Probiotic Study Group. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2008 Oct;122(4):788-94. Wiltshire EJ, Mohsin F, Chan A, Donaghue KC. Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms and protection from microvascular complications in adolescents with type 1 diabetes. Pediatr Diabetes. 2008 Aug;9(4 Pt 2):348-53. Wong A, Elder D, Zuccollo J. Changes in cause of neonatal death over a decade. NZ Med J. 2008 Jul 4;121(1277):39-46.

228 RESEARCH REPORT 2007/2008 UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF PATHOLOGY AND MOLECULAR MEDICINE

Edited Book Delahunt B (Editor) Research Review 2008. Wellington Medical Research Foundation: Wellington, pp 47. ISSN 1175-1053.

Journal – Research Article Bassett EG and Wakefield JStJ. Elastic fibers in myocardial scars in rats: development and interaction with other components. Connective Tissue Research 2008; 49: 321-327. Beddek AJ, Rawson P, Peng L, Snell R, Lehnert K, Ward H, Jordan TW. (2008) Profiling the metabolic proteome of mammary tissue. Proteomics 8:1502-155. Chung M, Jordan TW (Editors) (2008) Editorial. Recent advances in Membrane Proteomics. In Membrane Proteomics Special Issue of Proteomics 8: 3919. Chung M., Nakamura K, Jordan TW. The AOHUPO Membrane Proteomics Initiative, Fourth Workshop 22 June 2008, Cairns, Australia. Proteomics 2008; 8: 3920-3923. Denham JD, Steigler A, Wilcox C, Lamb DS, et al. (2008). Time to biochemical failure and prostate-specific antigen doubling time as surrogates for prostate cancer-specific mortality: evidence from the TROG 96.01 randomised controlled trial. Lancet Oncology 9(11):1058-68. Filoche SK, Soma D, van Bekkum M & Sissons CH. Plaques from different individuals yield different microbiota responses to oral-antiseptic treatment. FEMS Microbiology and Immunology 2008; 54: 27-36. Flint RS, Phillips ARJ, Power SE, Dunbar PR, Brown C, Delahunt B, Cooper GSJ, and Windsor JA. Acute pancreatitis severity is exacerbated by intestinal ischaemia – reperfusion conditioned mesenteric lymph. Surgery 2008; 143: 404-413. Gupta RK. Fine-Needle Aspiration Cytodiagnosis of Endometriosis I Cesarean Section Scar and Rectus Sheath Mass Lesions – A Study of Seven Cases. Diagnostic Cytopathology 2008; 36: 224-226. Gupta RK. Liesegang Rings in Fine Needle Aspirate of Breast Cysts With Predominance of Apocrine Cells: A Study of 14 Cases. Diagnostic Cytopathology 2008; 36: 701-704. Heffernan HM, Martin DR, Woodhouse RE, Morgan J, Blackmore TK. Invasive pneumococcal disease in New Zealand 1998- 2005 capsular serotypes and antimicrobial resistance. Epidemiol Infect 2008; 136:352-9. Holmes JD, Martin D, Ramsay C, Ypma E, Oster P. Combined administration of serogroup B meningococcal vaccine and conjugated serogroup C meningococcal vaccine is safe and immunogenic in college students. Epidemiol Infect 2008; 136: 790-799. Jovanovic L, Delahunt B, McIver B, Eberhardt NL, and Grebe SKG. Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone, Journal of Pathology 2008; 215: 145-154. Lamb DS, Slaney D, Smart R, Nacey JN, Russell G, Scott B, Johnson CA, Adams JD, Moran S, and Delahunt B. Prostate cancer: The new evidence base for diagnosis and treatment. Pathology 2007; 39: 537-544. Lennon DR, Farrell E, Martin DR, Stewart J. Once daily Amoxicillin versus twice-daily PenicillinV in group A and beta- Hemolytic streptococcus pharyngitis. Archives of Diseases in Children 2008; 93(6): 474-478. McNicholas A, Galloway Y, Martin D, Sexton K, O’Hallahan J. Surveillance of vaccine breakthrough cases following MeNZB vaccination. NZMJ 2008; 121: 1272. Merrilees AD, Bethwaite PB, Russell GL, Robinson RG, and Delahunt B. Parameters of perineural invasion in radical prostatectomy specimens lack prognostic significance. Modern Pathology 2008; 21: 1095-1100. Mittal A, Flint RJ, Fanous M, Delahunt B, Kilmartin PA, Cooper GJS, Windsor JA, and Phillips ARJ. The redox status of acute pancreatitis as measured by cyclic voltammetry: Initial rodent studies to assess disease severity. Critical Care Medicine 2008; 36: 866-872. Peacey M, Wilson S, Perret R, Ronchese F, Ward V, Young S and Baird M. Versatile RHDV virus-like particles can induce an anti-tumor response. Vaccine 2008; 26: 5334-7. Peng L, Rawson P, McLauchlan D, Lehnert K, Snell R, Jordan TW. Proteomic analysis of microsomes from lactating bovine mammary gland. Journal of Proteome Research 2008: 4: 1427-1432. Perret R and Ronchese F. Effector CD8+ T cells activated in vitro confer immediate and long-term tumour protection in vivo. Eur J Immunol 2008; 38: 2886-95 Perret R and Ronchese, F. Memory T cells in cancer immunotherapy: which CD8+ T cell population provides the best protection against tumours? Tissue Antigens 2008; 72: 187-94. Quinn KM, Rich FJ, Goldsack LM, deLisle GW, Buddle BM, Delahunt B, and Kirman JR. Accelerating the secondary immune response by inactivating CD4+ CD25+ T regulatory cells prior to BCG vaccination does not enhance protection against tuberculosis. European Journal of Immunology 2008; 38: 695-705. Samaratunga H, and Delahunt B. Ductal adenocarcinoma of the prostate: Current opinion and controversies. Quantitative and Analytical Histology and Cytology 2008; 30: 237-246. Stoitzner P, Green LK,Jung JY, Price KM, Ataera H, Kivell B and Ronchese F. Inefficient presentation of tumor-derived antigen by tumor-infiltrating dendritic cells. Cancer Immunol Immunother 2008: 57: 1665-73. Stoitzner P, Green LK, Jung JY, Price KM, Tripp CH, Malissen B, Kissenpfennig A, Hermans IF, Ronchese F. Tumor immunotherapy by epicutaneous immunization requires Langerhans cells. J Immunol 2008; 180: 1991-8.

Division of HEALTH SCIENCES 229 UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF PRIMARY HEALTH CARE AND GENERAL PRACTICE

Journal – Research Article Andrus T, Cox W, Gray B, Killingsworth C, Steiner P, McPherson B. Nonprofit health care organizations and universal health care coverage. Inquiry. 2008, 45(1):7-14. Barthow C, Moss C, McKinlay E, McCullough L, Wise D. To be involved or not: Factors that influence nurses’ involvement in providing treatment decisional support in advanced cancer. Eur J Oncol Nurs. 2008 Nov 14. Epub ahead of print. Elley CR, Robertson MC, Garrett S, Kerse NM, McKinlay E, Lawton B, Moriarty H, Moyes SA, Campbell AJ. Effectiveness of a falls-and-fracture nurse coordinator to reduce falls: a randomized, controlled trial of at-risk older adults. J Am Geriatr Soc. 2008, 56(8):1383-9. Gray, B. (2008). Managing the cross-cultural consultation: the importance of cultural safety. New Zealand Family Physician, 35(2): 124-130. Kerse N, Falloon K, Moyes SA, Hayman KJ, Dowell T, Kolt GS, Elley CR, Hatcher S, Peri K, Keeling S, Robinson E, Parsons J, Wiles J, Arroll B. DeLLITE depression in late life: an intervention trial of exercise. Design and recruitment of a randomised controlled trial. BMC Geriatr. 2008 24;8:12. Lawton BA, Rose SB, Cormack DM, Stanley J, Dowell AC. The menopause symptom profile of Mäori and non-Mäori women in New Zealand. Climacteric. 2008;11(6):467-74. Lawton B, Rose S, Kieser J, Broadbent J, Sussex P, Thomson M, Dowell A. Disparities in edentulism and tooth loss between Mäori and non-Mäori New Zealand women. Aust N Z J Public Health. 2008 Jun; 32(3):254-60. Lawton BA, Rose SB, Bromhead C, Gaitanos LA, MacDonald EJ, Lund KA. High prevalence of Mycoplasma genitalium in women presenting for termination of pregnancy. Contraception. 2008 77(4):294-8. McBain L. Documentation of cardiovascular risk factors. N Z Med J. 2008 14;121(1270):106. Pullon S. Competence, respect and trust: key features of successful interprofessional nurse-doctor relationships. J Interprof Care. 2008 22(2):133-47. Pullon S, Lum R. Clinical teaching capacity in New Zealand general practice. N Z Med J. 2008 25;121(1268):U2895. Rose SB, Elley CR, Lawton BA, Dowell AC. A single question reliably identifies physically inactive women in primary care. N Z Med J. 2008 25;121(1268):U2897. Rose SB, Smith MC, Lawton BA. “If everyone does it, it’s not a big deal.” Young people talk about chlamydia testing. N Z Med J. 2008 4;121(1271):33-42. Turner N, Hoare KJ, Dowell T. Children in New Zealand: their health and human rights. N Z Med J. 2008 4;121(1271):6-10. Welton AJ, Vickers MR, Kim J, Ford D, Lawton BA, MacLennan AH, Meredith SK, Martin J, Meade TW; WISDOM team. Health related quality of life after combined hormone replacement therapy: randomised controlled trial. BMJ. 2008 21;337:a1190. Yang, C.F., & Gray, B. (2008). Bilingual medical students as interpreters- what are the benefits and risks? NZMJ, 121(1282): 15-28.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF PSYCHOLOGICAL MEDICINE

Book St George I ed. (2008). Cole’s Medical Practive in New Zealand. Medical Council of New Zealand.

Chapter in Book Oakley-Browne M A, Wells J E & M, S. K. (2008). Te Rau Hinengaro: The New Zealand Mental Health Survey. In: R C Kessler; T B Ustun (Eds). In The WHO World Mental Health Surveys: Global Perspectives on the Epidemiology of Mental Disorders (ed. R. C. Kessler). Cambridge University Press: New York.

Journal – Research Article Barnfield T V & Mathieson F M (2007). Assessing the Development of Competence During Postgraduate Cognitive- Behavioral Therapy Training. Journal of Cognitive Psychotherapy: An International Quarterly 21, 140 - 147. He Y, Zhang M, Lin E H B , Bruffaerts R, Posada-Villa J, Angermeyer M C, Levin D, de Girolamo G, Uda H, Mneimneh Z, Benjet C, de Graaf R, Scott K M, Gureje O, Seedat S, Haro J M, Bromet E J, Alonso J, Von Korff M & C, K. R. (2008). Mental disorders among persons with arthritis: results from the World Mental Health Surveys. Psychological Medicine, 1639 - 1650. Kake T R, Arnold R & M, E. P. (2008). Estimating the prevalence of schizophrenia amongst New Zealand Mäori: a capture- recapture approach. Australian and New Zealand Journal of Psychiatry 42 148 - 151. Mathieson F M, Barnfield T & Beaumont G (2008). Are we as good as we think we are? Self- assessment versus other forms of assessment of competence in psychotherapy. The Cognitive Behaviour Therapist, 1-8. Ormel J, Petukhova M, Chatterji S, Aguilar-Gaxiola S, Alonso J, Angermeyer M C, Bromet E J, Burger H, Demyttenaere K, de Girolamo G, Haro J M, Hwang I, Karam E G, Kawakami N, Nepine J P, Medina-Mora M E, Posada-Villa J, Sampson N, Scott K M, Ustun T B, Von Korff M, Williams D, Zhang M & C, K. R. (2008). Disability and treatment of specific mental

230 RESEARCH REPORT 2007/2008 and physical disorders aross the world; Results from the WHO World Mental Health Surveys. The British Journal of Psychiatry (2008) 192, 368-375. Palmer S E, McLean R M, Ellis P M & M, H.-W. (2008). Life-Threatening Clozapine-Induced Gastrointestinal Hypomotility: An Analysis of 102 Cases. Journal of Clinical Psychiatry, 759 - 68. Scott K M, Bruffaerts R, Simon G. E, Alonso J, Angermeyer M, de Girolamo G, Demyttenaere K, Gasquet I, Gureje O, Haro J M, Karam E, Kessler R C, Levinson D, Medina Mora M E, Oakley Browne M A, Ormel J, Villa J P, Uda H & Von Korff M (2008). Obesity and mental disorders in the general population: results from the world mental health surveys. International Journal of Obesity 32, 192-200. Scott K M, McGee M A, Wells, J. E. & A, O. B. M. (2008). Obesity and mental disorders in the adult general population. Journal of Psychosomatic Research 64, 97-105. Scott K M, McGee M A, Schaaf D & Baxter J (2008). Mental-Physical comorbidity in an ethnically diverse population. Social Science & Medicine 66, 1165-1173. Scott K M, Von Korff M, Alonso J, Angermeyer M C, Bromet E, B. R., de Girolamo G, de Graaf R, Fernandez A, Gureje O, He Y, Kessler R C, Kovess V, Levinson D, Medina-Mora M E, Mneimneh Z, Oakley Browne M A, Posada-Villa J, Tachimori H & D., W. (2008). Age patterns in the prevalence of DSM-IV depressive/anxiety disorders with and without physical co- morbidity. Psychological Medicine 38, 1659 - 1669. Scott K M, Von Korff M, Alonso J, Angermeyer M C, Bromet E, Fayyad J, de Girolamo G, Demyttenaere K, Gasquet I, G. O., Haro J M, He Y, Kessler R C, Levinson D, Medina Mora M E, Oakley Browne M, Ormel J, Posada-Villa J, Watanabe M & D, W. (2009). Mental-physical co-morbidity and its relationship with disability: results from the World Mental Health Surveys. Psychological Medicine 39, 33-43. Scott K M, Von Korff M, Alonso J, Angermeyer M C, Benjet C, Bruffaerts R, de Girolamo G, Haro J M, Kessler R C, Kovess V, Ono Y, Ormel J & J, P.-V. (2008). Childhood Adversity, early-onset depressive/anxiety disorders, and adult-onset asthma. Psychosomatic Medicine, 1035 -1043. Siegert R J, Weatherall M & B, B. E. (2008). Is implicit sequence learning impaired in schizophrenia? A meta-analysis. Science Direct Brain and Cognition 67 (2008), 351-359. Von Korff M, Crane P K, Alonso J, Vilagut G, Angermeyer M C, Bruffaerts R, de Girolamo G, Gureje O, de Graaf R, Huang Y, Iwata N, Karam E G, Lovess V, Lara C, Levinson D, Posada-Villa J, Scott K M & J, O. (2008). Modified WHODAS-II provides valid measure of global disability but filter items increased skewness. Journal of Clinical Epidemiology 61, 1132 - 1143. Wells J E, Degenhardt L, Bohnert K, Scott K M & C, A. J. (2008). Geographical clustering of cannabis use: Results from the New Zealand Mental Health Survey 2003 - 2004. Drug and Alcohol Dependence, 309 - 316.

Journal – Other Dronsfield AT & Ellis P M (2008). Fighting cancer with chemicals – the early years. Education in Chemistry, 80-83. Dronsfield A T & Ellis P M eds. (2008). Cocaine to Novocaine – A chemical journey. Dronsfield A T & Ellis P M (2008). Librium and Valium – anxious times. Education in Chemistry 45, 148-151. Dronsfield A T, Brown T & Ellis P M (2008). Synthetic dyes and the start of chemotherapy. Royal Society of Chemistry, Historical Group newsletter August 2008, 15-18. MacDonald, J. (2008). Supervision of postgraduate psychiatric Trainees in New Zealand: as exploration of the “individual hour”. In: Psychological Medicine. University of Otago: Wellington. MacDonald, J. (2008). Clinical Supervision. In Hunter Institute of Mental Health – Newcastle 2008 Course Guide: James Fletcher Hospital, Newcastle, Sydney, Australia. MacDonald J (2008). Impressions of the Health Committee. Medical Council News.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF PUBLIC HEALTH

Journal – Research Article Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and cancer of the head and neck: case-control study. Otolaryngol Head Neck Surg. 2008 Mar;138(3):374-80. Aldington S, Harwood M, Cox B, Weatherall M, Beckert L, Hansell A, Pritchard A, Robinson G, Beasley R; Cannabis and Respiratory Disease Research Group. Cannabis use and risk of lung cancer: a case-control study. Eur Respir J. 2008 Feb;31(2):280-6. Baker M, Das D, Venugopal K, Howden-Chapman P. Tuberculosis associated with household crowding in a developed country. J Epidemiol Community Health. 2008 Aug;62(8):715-21. Barnard LF, Baker MG, Hales S, Howden-Chapman PL. Excess winter morbidity and mortality: do housing and socio- economic status have an effect? Rev Environ Health. 2008 Jul-Sep;23(3):203-21. Blakely T. “Social injustice is killing people on a grand scale”. N Z Med J. 2008 Sep 5;121(1281):7-11. Blakely T. Iconography and Commission on the Social Determinants of Health (and health inequity). J Epidemiol Community Health. 2008 Dec;62(12):1018-20.

Division of HEALTH SCIENCES 231 Blakely T, Atkinson JN, Fawcett J. Ethnic counts on mortality and census data (mostly) agree for 2001-2004: New Zealand Census-Mortality Study update. N Z Med J. 2008 Sep 5;121(1281):58-62. Blakely T, Tobias M, Atkinson J. Inequalities in mortality during and after restructuring of the New Zealand economy: repeated cohort studies. BMJ. 2008 Feb 16;336(7640):371-5 Britton J, Edwards R. Tobacco smoking, harm reduction, and nicotine product regulation. Lancet. 2008 Feb 2;371(9610):441-5. Carter KN, Blakely T, Collings S, Imlach Gunasekara FH, Richardson K. What is the association between wealth and mental health? J Epidemiol Community Health. 2008 Nov 21. Epub ahead of print. Carter KN, Blakely T, Collings S, Imlach Gunasekara FH, Richardson K. What is the association between wealth and mental health? J Epidemiol Community Health. 2008 Nov 21. Epub ahead of print. Cunningham R, Sarfati D, Hill S, Kenwright D. An audit of colon cancer data on the New Zealand Cancer Registry. N Z Med J. 2008 Aug 8;121(1279):46-56. D’Souza AJ, Blakely TA, Woodward A. The effect of eradicating poverty on childhood unintentional injury mortality in New Zealand: a cohort study with counterfactual modelling. J Epidemiol Community Health. 2008 Oct;62(10):899-904. Edwards R, Bowler T, Atkinson J, Wilson N. Low and declining cigarette smoking rates among doctors and nurses: 2006 New Zealand Census data.N Z Med J. 2008 Oct 17;121(1284):43-51. Edwards R, Thomson G, Wilson N, Waa A, Bullen C, O’Dea D, Gifford H, Glover M, Laugesen M, Woodward A. After the smoke has cleared: evaluation of the impact of a new national smoke-free law in New Zealand. Tob Control. 2008 Feb;17(1):e2. Edwards R, Thornton J, Ajit R, Harrison RA, Kelly SP. Cigarette smoking and primary open angle glaucoma: a systematic review. J Glaucoma. 2008 Oct-Nov;17(7):558-66. Edwards R, Wilson N, Thomson G. Tobacco control in New Zealand: top marks for new smoking cessation guidelines, must try harder elsewhere. N Z Med J. 2008 Jun 20;121(1276):5-8. Gander P, Signal L. Who is too old for shift work? Developing better criteria. Chronobiol Int. 2008 Apr;25(2):199-213. Gander P, van den Berg M, Signal L. Sleep and sleepiness of fishermen on rotating schedules. Chronobiol Int. 2008 Apr;25(2):389-98. Gillespie-Bennett J, Pierse N, Wickens K, Crane J, Nicholls S, Shields D, Boulic M, Viggers H, Baker M, Woodward A, Howden-

Chapman P; Housing, Heating, and Health Team. Sources of nitrogen dioxide (NO2) in New Zealand homes: findings from a community randomized controlled trial of heater substitutions. Indoor Air. 2008 Dec;18(6):521-8. Grigg J, Kulkarni N, Pierse N, Rushton L, O’Callaghan C, Rutman A. Black-pigmented material in airway macrophages from healthy children: association with lung function and modeled PM10. Res Rep Health Eff Inst. 2008 Jun;(134):1-23. Gunasekara FI, Carter K, Blakely T. Glossary for econometrics and epidemiology. J Epidemiol Community Health. 2008 Oct;62(10):858-61. Hiscock R, Pearce J, Blakely T, Witten K. Is Neighborhood Access to Health Care Provision Associated with Individual-Level Utilization and Satisfaction? Health Serv Res. 2008 Jul 29. Epub ahead of print. Howden-Chapman P, Pierse N, Nicholls S, Gillespie-Bennett J, Viggers H, Cunningham M, Phipps R, Boulic M, Fjällström P, Free S, Chapman R, Lloyd B, Wickens K, Shields D, Baker M, Cunningham C, Woodward A, Bullen C, Crane J. Effects of improved home heating on asthma in community dwelling children: randomised controlled trial. BMJ. 2008 Sep 23;337. Jatrana S, Blakely T. Ethnic inequalities in mortality among the elderly in New Zealand. Aust N Z J Public Health. 2008 Oct;32(5):437-43. Jenkin G, Wilson N, Hermanson N. Identifying ‘unhealthy’ food advertising on television: a case study applying the UK Nutrient Profile model. Public Health Nutr. 2008 Jul 11:1-10. Keall MD, Baker M, Howden-Chapman P, Cunningham M. Association between the number of home injury hazards and home injury. Accid Anal Prev. 2008 May;40(3):887-93 Keall MD, Newstead S. Are SUVs dangerous vehicles? Accid Anal Prev. 2008 May;40(3):954-63. Kingham S, Fisher G, Hales S, Wilson I, Bartie P. An empirical model for estimating census unit population exposure in areas lacking air quality monitoring. J Expo Sci Environ Epidemiol. 2008 Mar;18(2):200-10. McLeod M, Kelly H, Wilson N, Baker MG. Border control measures in the influenza pandemic plans of six South Pacific nations: a critical review. N Z Med J. 2008 Jul 25;121(1278):62-72. Norton KJ, Wilkins K, O’Connor R, Wilson N, Edwards R, Peace J. Properties of “light” cigarettes sold in New Zealand.N Z Med J. 2008 Sep 5;121(1281):107-10. Peace J, Wilson N, Thomson G, Edwards R. Recent changes in cigarette packaging in New Zealand may continue to mislead smokers. N Z Med J. 2008 Jan 28;121(1268):U2908. Quedley M, Ng B, Sapre N, Blakiston M, Crawford A, Devadas R, McLaren H, Anand S, Tipu M, Dayal V, Chandrasiri S, Thomson G, Edwards R. In sight, in mind: retailer compliance with legislation on limiting retail tobacco displays. Nicotine Tob Res. 2008 Aug;10(8):1347-54 Pearce J, Hiscock R, Blakely T, Witten K. A national study of the association between neighbourhood access to fast-food outlets and the diet and weight of local residents. Health Place. 2009 Mar;15(1):193-7. Epub 2008 Apr 10. Pearce J, Hiscock R, Blakely T, Witten K. The contextual effects of neighbourhood access to supermarkets and convenience stores on individual fruit and vegetable consumption. J Epidemiol Community Health. 2008 Mar;62(3):198-201. Raymont A, Morgan S, McLeod D, Dowell A, van Rij A, Cumming J, Pledger M, Dew K, Cormack D. New Zealand general practitioners’ non-urgent referrals to surgeons: who and why? N Z Med J. 2008 Jun 6;121(1275):57-64. Riddick L, Thomson G, Wilson N, Purdie G. Killing the canary: the international epidemiology of the homicide of media workers. J Epidemiol Community Health. 2008 Aug;62(8):682-8.

232 RESEARCH REPORT 2007/2008 Sahu A, Edwards R, Harrison RA, Thornton J, Kelly SP. Attitudes and behaviour of ophthalmologists to smoking cessation. Eye. 2008 Feb;22(2):246-50. Shaw C, Cunningham R, Sarfati D. From screening criteria to colorectal cancer screening: what can New Zealand learn from other countries? N Z Med J. 2008 Aug 8;121(1279):84-95. Signal L, Lanumata T, Robinson JA, Tavila A, Wilton J, Ni Mhurchu C. Perceptions of New Zealand nutrition labels by Mäori, Pacific and low-income shoppers. Public Health Nutr. 2008 Jul;11(7):706-13. Smith MB, Signal L. Global influences on milk purchasing in New Zealand - implications for health and inequalities. Global Health. 2009 Jan 19;5(1):1. Stevenson AM, Bradshaw R, Cook J, Cunningham R, Riddick L, Miller R, Edwards R, Wilson N, Thomson G. Majority of smokers and non-smokers in favour of smokefree parks in New Zealand. N Z Med J. 2008 May 23;121(1274):108-10. Tay S, Thomson G. What Wellington region city councillors think of smokefree outdoor places. N Z Med J. 2008 Jun 20;121(1276):15-28. Thomson G, Hoek J, Edwards R, Gifford H. Evidence and arguments on tobacco retail displays: marketing an addictive drug to children? N Z Med J. 2008 Jun 20;121(1276):87-98. Thomson G, Wilson N. Public attitudes to laws for smokefree private vehicles: A brief review. Tob Control. 2008 Dec 3. Epub ahead of print. Thomson G, Wilson N, Bushell L, Al Matar W, Ball B, Chiu J, Culliford N, Gately C, Gibson K, Hudson J, Hunt P, Rangamuwa K, Tapp D, Wickramaratne H, Young V. Butt lengths differ by area deprivation level: a field study to explore intensive smoking.Nicotine Tob Res. 2008 May;10(5):927-31. Thomson G, Wilson N, Weerasekera D, Edwards R. Ninety-six percent of New Zealand smokers support smokefree cars containing preschool children. N Z Med J. 2008 Nov 7;121(1285):139-40. Thomson G, Wilson N, Edwards R, Woodward A. Should smoking in outside public spaces be banned? Yes. BMJ. 2008 Dec 11;337:a2806. doi: 10.1136/bmj.a2806. Thomson G, Wilson N, Hoek J. A call to reduce harm from tobacco pack marketing and bolster consumer health protection in New Zealand. N Z Med J. 2008 Oct 17;121(1284):98-101. Tobias M, Templeton R, Collings S. How much do mental disorders contribute to New Zealand’s tobacco epidemic? Tob Control. 2008 Oct;17(5):347-50. Tracey M, Soeberg M, Blakely T. Mapping progress: the evaluation and monitoring work of the Cancer Control Council of New Zealand 2005-2007. N Z Med J. 2008 Aug 8;121(1279):75-83. Walker T, Signal L, Russell M, Smiler K, Tuhiwai-Ruru R; Otaki Community Health Centre; Te Wakahuia Hauora; Te Aitanga a Hauiti Hauora; Turanga Health. The road we travel: Mäori experience of cancer. N Z Med J. 2008 Aug 8;121(1279):27-35. Wickens K, Black PN, Stanley TV, Mitchell E, Fitzharris P, Tannock GW, Purdie G, Crane J; Probiotic Study Group. A differential effect of 2 probiotics in the prevention of eczema and atopy: a double-blind, randomized, placebo-controlled trial. J Allergy Clin Immunol. 2008 Oct;122(4):788-94. Wijesinghe M, Perrin K, Harwood M, Weatherall M, Beasley R. The risk of asthma mortality with inhaled long acting beta- agonists. Postgrad Med J. 2008 Sep;84(995):467-72. Wilson N, Baker M. Access to training for Mäori and Pacific public health workers: evaluation of a summer school. N Z Med J. 2008 Aug 22;121(1280):83-4. Wilson N, Baker MG, Jennings LC. The clioepidemiology of pandemic influenza and next steps for pandemic influenza research in New Zealand. N Z Med J. 2008 Oct 17;121(1284):6-10. Wilson N, Clegg J, Hardy G. What informs and shapes ethical practice in intellectual disability services? J Intellect Disabil Res. 2008 Jul;52(7):608-17. Wilson N, Baker M, Shaw C. “One ticket to town and just letting you know I have syphilis.” Time to replace the Health Act 1956? N Z Med J. 2008 Dec 12;121(1287):95. Wilson N, Maher A, Thomson G, Keall M. Vehicle emissions and consumer information in car advertisements. Environ Health. 2008 Apr 29;7:14. Wilson N, Thomson G, Edwards R, Weerasekera D, Laugesen M. Most New Zealand smokers support having fire-safe cigarettes: national survey data. N Z Med J. 2008 Nov 28;121(1286):134-5. Wilson N, Thomson G, Edwards R. Use of four major tobacco control interventions in New Zealand: a review. N Z Med J. 2008 Jun 20;121(1276):71-86. Witten K, Hiscock R, Pearce J, Blakely T. Neighbourhood access to open spaces and the physical activity of residents: a national study. Prev Med. 2008 Sep;47(3):299-303.

UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF RADIATION THERAPY

Journal – Research Article Herst PM, Hesketh EL, Ritchie DS, Berridge MV. Glycolytic metabolism confers resistance to combined all-trans retinoic acid and arsenic trioxide-induced apoptosis in HL60rho0 cells. Leuk Res. 2008 Feb;32(2):327-33 Herst PM, Perrone GG, Dawes IW, Bircham PW, Berridge MV. Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits. FEMS Yeast Res. 2008 Sep;8(6):897-905.

Division of HEALTH SCIENCES 233 UNIVERSITY OF OTAGO, WELLINGTON DEPARTMENT OF SURGERY AND ANAESTHESIA

Journal – Research Article Lamb DS, Bupha-Intr O, Bthwaite P, Murray J, Nacey JN, Russell GL, Delahunt B. Prostate cancer – are ethnic minorities disadvantaged? Anticancer Research 28 3891-3896 (2008). Tzeng YC, Sin PY, Galletly DC. Human sinus arrhythmia: inconsistencies of a teleological hypothesis. Am J Physiol Heart Circ Physiol. Epub Oct 31 2008 ;296(1):H65-70. Omundsen, M.S., Dennett, E., and Walker, H. (2008). Patient recall after diagnostic laparoscopy for abdominal pain. ANZ Journal of Surgery 78: 49-51. Wakeman CJ, Dobbs BR, Frizelle FA, Bissett IP, Dennett ER, Hill AG, Thompson-Fawcett MW. The impact of splenectomy on outcome after resection for colorectal cancer: a multicenter, nested, paired cohort study. Dis Colon Rectum. 2008 Feb;51(2):213-7.

SCHOOL OF PHARMACY

Journal – Research Article Aaltonen, J., Gordon, K.C., Strachan, C.J & Rades, T. (2008). Perspectives in the use of spectroscopy to characterise pharmaceutical solids. Science Direct, International Journal of Pharmaceutics 364 (2008) 159-169. Al-Salami, H., Butt, G., Fawcett, J.P., Tucker, I.G., Golocorbin-Kon, S. & Mikov, M (2008). Probiotic treatment reduces blood glucose levels and increases systemic absorption of gliclazide in diabetic rats. European Journal of Drug Metabolism and Pharmacokinetics 2008 Vol 33 No 2 pp 101-106. Al-Salami, H., Butt, G., Tucker, I.G., Srkbic, R., Golocorbin-Kon, S. & Mikov, M (2008). Probiotic pre-treatment reduces gliclazide permeation (ex vivo) in healthy rats but increases it in diabetic rates to the level seen in untreated healthy rats. Arch Drug Info 2008; 1:35-41 Al-Salami, H., Butt, G., Tucker, I.G.,. & Mikov, M (2008). Influence of the semisynthetic bile acid MKC on the Ileal permeation of gliclazide in vitro in healthy and diabetic rates treated with probiotics. Methods Find Exp Clin Pharmacol 2008, 30(2): 107-113 Al-Salami, H., Butt, G., Tucker, I.G., Srkbic, R., Golocorbin-Kon, S. & Mikov, M (2008). Probiotic treatment proceeded by a single dose of bile acid and gliclazide exert the most hypoglycaemic effect in type 1 diabetic rats. Medical Hypotheses and Research Vol 4, No 2, July 2008. Al-Salami, H., Butt, G., Tucker, I.G.,. & Mikov, M (2008). Influence of the semisynthetic bile acid (MKC) on the Ileal permeation of gliclazide in healthy and diabetic. Pharmacological Reports 2008, 60, 532-541. Al-Sallami, H., Ferguson, R., Wilkins, G., Gray, A. & Medlicott, N. (2008). Bleeding events in patients receiving enoxaparin for the management of non-ST-elevation acute coronary syndrome (NSTEACS) at Dunedin Public Hospital. NZMJ 2008; 121(1285):87-95 Ashton, J.C., Wright, J.L., McPartland, J.M. & Tyndall J.D.A (2008). Cannabinoid CB1 & CB2 receptor ligand specificity and the development of CB2-selecetive agonists. Current Medicinal Chemistry, 2008, 15, 1428-1443. Barras, M.A., Duffull, S.B., Atherton, J.J. & Green, B. (2008). Individualized Compared with conventional dosing of enoxapar. Clinical Pharmacolofy and Therapeutics, Volume 83 number 6 June 2008. Braund, R., Chuah, F., Gilbert, R., Gn, G., Soh, A., Yin Tan, L., Tiong, H. & Yuen, Y. (2008). Identification of the reasons for medical returns. NZFP Volume 35 Number 4 August 2008. Capstick, S., Beresford, R. & Gray, A. (2008). Rural pharmacy in New Zealand: Effects of a compulsory externship on student perspectives and implcations for worksforce shortage. Australian Journal of Rural Health (2008) 16, 150-155. Chan, A., Isbister, G.K., Kirkpatrick, C.M., & Duffull, S.B. (2008). Assessing risk of prolonged QT interval-a survey of emergency physicians. International Journal of Emergency Medicine (2008). 1:35-41 Chieng. N, Rades, T. & Saville, D. (2008). Formation and physical stability of the amorphous phase of ranitidine hydrochloride polymorphs prepared by cryo-milling. European Journal of Pharmaceutics and Biopharmaceutics 68: 771 – 780 (2008). Devi, S., Bruno Dos Santos, R., Kazal, I., Leon, L., Ram, S. & Wu, M. Supervised by Braund, R. (2008). Complementary medicine: What is the evidence? NZ Pharmacy Journal March 2008, Vol 28, No 1. Feltrin, K.L., Little, T.J., Meyer, J.H., Horowitz, M., Rades, T., Wishart, J. & Feinle-Bisset, C. (2008). Comparative effects of intraduodenal infusions of lauric and oleic acids on antropyloroduldenal motility, plasma cholecystokinin and peptide YY, appetite, and energy intake in healthy men. The American Journal of Clinical Nutrition 2008;87:1181-7. Gordon, S., Saupe, A., McBurney, W., Rades, T. & Hook S. (2008). Comparison of chitosan nanoparticles and chitosan hydrogels for vaccine delivery. Journal of Pharmacy and Pharmacology 60: 1591 – 1600 (2008) Graeser, K., Strachan, C.J, Patterson, J.E., Gordon, K.C. & Rades T (2008). Physico-chemical properties and stability of two differently prepared amorphous forms of simvastatin. Crystal Growth & Design 8: 128-135 (2008). Graf, A., Ablinger, E., Peters, S., Zimmer, A., Hook, S. & Rades, T. (2008). Microemulsions containing lecithin and sugar-based surfactants: nanoparticle templates for delivery of proteins and peptides. International Journal of Pharmaceutics 350: 351 – 360 (2008).

234 RESEARCH REPORT 2007/2008 Graf. A., Jack, K.S., Whittaker, A.K., Hook, S. & Rades, T. (2008). Protein delivery using nanoparticles based on microemulsions with different structure-types. European Journal of Pharmaceutical Sciences 33: 434 – 444 (2008). Green, J.A (2008). Party on? Life BZP-based party pills. The New Zealand Medical Journal Vol 121 No 1283 pg 35-42. Halberstadt, J. & Green, J. (2008). Carryover effects of analytic thought on preference quality. Journal of Experimental Social Psychology 44 (2008) 1199-1203. Heinz, A., Atassi, F., Gordon, K.C &, Rades, T. (2008) Characterizing an amorphous system exhibiting trace crystallinity: a case study with saquinavir. Crystal Growth & Design 8: 119-127 (2008). Ho, L., Müller, R., Gordon, K.C., Kleinebudde, P., Pepper, M., Rades, T., Shen, Y.C., Taday, P.F. & Zeitler, J. (2008). Applications of terahertz pulsed imaging to sustained-release tablet film coating quality assessment and dissolution performance. Journal of Controlled Release 129: 78 – 87 (2008). Janmahasatian, S., Duffull, S.B., Chagnac, A., Kirkpatrick, C.M. & Green, B. (2008). Lean body mass normalizes the effect of obesity on renal function. British Journal of Clinical Pharmacology 65:6 964-965. Junyaprasert, V.B., Boonme, P., Wurster, D.E. & Rades, T. (2008). Aerosol OT microemulsions as carriers for transdermal delivery of hydrophobic local anaesthetics. Informa healthcare Drug Delivery 15:323-330. Khunawattanakul, W., Puttipipatkhachorn, S., Rades, T. & Pongjanyakul, T. Chitosan - magnesium aluminum silicate composite dispersions: Characterization of rheology, flocculate size and zeta potential. International Journal of Pharmaceutics 351: 227 – 235 (2008). Kumar, V.V.P & Duffull, S.B. (2008). Methods to account for inaccuracies in the dosing history when performing population pharmacokinetic analysis. Pharmaceutical Research. Liu, P., Chary, S., Devaraj, R., Jing, Y., Darlington, C.L., Smith, P.F., Tucker, I.G. & Zhang, H. (2008). Effects of aging on agmatine levels in memory-associated brain structures. Hippocampus 18:853-856. Liu, P., Collie, N.D., Chary, S., Jing, Y. & Zhang, H. (2008). Rapid Communication. Hippocampus 18:1094-1098. Liu, P., Collie, N.D., Chary, S., Jing, Y. & Zhang, H. (2008). Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus 18:1094-1098. Liu., P., Gupta , N., Jing, Y. & Zhang, H.(2008). Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience 155 (2008) 789-796. Liu, P., Rushaidhi, M., Collie, N.D., Leong, M. & Zhang, H. (2008). Behavioural effects of Intracerebroventricular microinfusion of agmatine in adult rats. Behavioural Neuroscience 2008.Vol. 122, No 3 557-569. Lu, M.Y., Silvam, A., Mujoo, H., Naidoo, A. & Tucker, I. (2008). Drug transporters play key role. NZ Pharmacy September 2008. McBurney, W.T., Lendemans, D.G., Myschik, J., Hennessy, T., Rades, T. & Hook, S. (2008). In vivo activity of cationic immune stimulating complexes (PLUSCOMs). Science Direct Vaccine 26 (2008) 4549-4556. McGoverin, C.M., Rades, T. & Gordon, K. (2008). Recent pharmaceutical applications of Raman and terahertz spectroscopies. Journal of Pharmaceutical Sciences. McGree, J.M., Eccleston, J.A. & Duffull, S.B (2008). Compound optimal design criteria for nonlinear models. Journal of Biopharmaceutical Statistics 18: 646-661 2008. Mikov, M., Al-Salami, H., Golocorbin-Kon, S., Skrbic, R., Raskovic, A. & Fawcett, P. (2008). The influence of 3a, 7a-dihydroxy- 12-keto-5β-cholanate on gliclazide pharmacokinetics and glucose levels in a rat model of diabetes. European Journal of Drug Metabolism and Pharmacokinetics 2008. Vol. 33 No. 3 pp. 137-142. Millar, T,. Sandilya, R., Tordoff, J. & Ferguson, R. (2008). Documenting pharmacist’s clinical interventions in New Zealand hospitals. Pharmacy World and Science 2008; 30(1):99-106. Mukhopadhyay, D., Saville, D. & Tucker, I.G. (2008). Crosslinking of drug-alginate granules part 2. Effect of granule preparation and composition on granule properties. Science Direct, International Journal of Pharmaceutics 356 (2008) 193-199. Myschik, J., Eberhardt, F., Rades, T. & Hook, S. (2008). Immunostimulatory biodegradable implants containing the adjuvant Quil-A – Part I: Physicochemical characterisation. Journal of Drug Targeting 16: 213 – 223 (2008). Myschik, J., Hennessy, T., McBurney, W.T., Phipps-Green, A., Rades, T. & Hook, S. (2008). Immunogenicity of lipid sustained release implants containing imiquimod, α-Galactosylceramide, or Quil-A. Die Pharmazie 63: 686 – 692 (2008). Myschik, J., McBurney, W.T., Hennessy, T., Phipps-Green, A., Rades, T., Hook, S. (2008). Immunostimulatory biodegradable implants containing the adjuvant Quil-A – Part II: In vivo evaluation. Journal of Drug Targeting 16: 224 – 232 (2008). Myschik, J., McBurney, W.T., Rades, T. & Hook, S. (2008). Immunostimulatory lipid implants containing Quil-A and DC- cholesterol. International Journal of Pharmaceutics 363: 91 – 98 (2008). Norris, P., Reith, D., Tordoff. J. & Ragupathy, R. (2008). Are New Zealand children still therapeutic orphans? Childrenz Issues. Vol 12, No 1, 2008. Norris, P. (2008). How to spend a sixth of your entire economy on healthcare. The New Zealand Medical Journal 5 September 2008, Vol 121 No 1281. Numata, M., Fawcett, J.P. & Rosengren, R.J. (2008). Induction of in vitro EROD activity and in vivo caffeine metabolism in two species of New Zealand birds. Science Direct Environmental Toxicology and Pharmacology 25 (2008) 358-364. Numata, M., Fawcett, J.P., Saville, D. & Rosengren, R. (2008). Hepatic cytochrome P450 activity and pollutant concentrations in paradise shelducks and southern black-backed gulls in the South Island of New Zealand. Ecotoxicology, 17(8):697-708. Patterson, J.E., James, M.B., Forster, A.H, Rades, T. (2008). Melt extrusion and spray drying of carbamazepine and dipyridamole with polyvinylpyrrolidone/vinyl acetate copolymers. Drug Development and Industrial Pharmacy 34: 95 – 106 (2008).

Division of HEALTH SCIENCES 235 Reitz, C., Strachan, C. & Kleinebudde, P. (2008). Solid Lipid extrudates as sustained-release matrices: The Effect of surface structure on drug release properties. European Journal of Pharmaceutical Sciences 35 (2008) 335-343. Roos, J.J., Kirkpatrick, C.M.J, Tett, S.E., McLaughlan, A.J & Duffull, S.B (2008). Development of a sufficient design for estimation of fluconazole pharmacokinetics in people with HIV infection. British Journal of Clinical Pharmacology 66:4, 455-466. Sherwin, C.M.T., Broadbent, R.S., Medlicott, N.J. & Reith, D.M. (2008). Individualising netilmicin dosing in neonates. European Journal of Clinical Pharmacology (2008) 64:1201-1208. Sherwin, C.M.T., Broadbent, R., Young, S., Worth, J., McCaffrey, F., Medlicott, N.J. & Reith, D. (2008). Utility of Interluekin-12 and interleuklin-10 in comparison with other cytokines and acute-phase reactants in the diagnosis of neonates sepsis. American Journal of Perinatology Nov 2008 Vol 25 Issue 10 629-636. Sherwin, C., Medlicott, N., Broadbent, R. & Reith, D. (2008). Neonatal sepsis and aminoglycosides. Pharmacy Journal New Zealand April 2008 16-19. Sherwin, C.M.T., Svahn, S., Broadbent, R.S., Van Der Linden, A., Medlicott, N.J. & Reith, D.M. (2008). Netilmicin withdrawal: impact on neonates. The New Zealand Medical Journal, Vol 121 No 1284. Siow, L. K., Rades, T. & Lim, M, Lim (2008). Cryo-responses of two types of large unilamellar vesicles in the presence of non- permeable or permeable cryoprotecting agents. Cryobiology 57 (2008) 276-285. Tanos, P.P., Isbister, G.K., Lalloo, D.G., Kirkpatrick, C.M.J. & Duffull, S.B. (2008). A model for venom-induced consumptive coagulopathy in snake bite. ScienceDirect Toxicon 52 (2008) 769-780. Tantipolphan, R., Rades, T. & Medlicott, N.J. (2008). Insights into the structure of protein by vibrational spectroscopy. Current Pharmaceutical Analysis 4: 53 – 68 (2008). Tian, F., Rades, T. & Sandler, N. (2008). Visualizing solvent medicated phase transformation behaviour of carbamazepine polymorphs by principal component analysis. AAPS PharmSciTech, Vol 9 No2, June 2008. Tordoff, J.M., Norris, P.T. & Reith, D.M.(2008). “Price Management” and its impact on hospital pharmaceutical expenditure and the availability of medicines in New Zealand hospitals. Value in Health Volume 11 No 7 (2008) 1214-1226. Tordoff. J., Norris, P., Reith, D. & Ragupathy, R. (2008). Are New Zealand children still therapeutic orphans? Childrenz Issues. Vol 12, No 1, 2008. Tyndall, J.D.A., Kelso, M.J., Clingan, P. & Ranson, M (2008). Peptides and small molecules targeting the plasminogen activation system: towards prophylactic anti-metastasis drugs for breast cancer. Recent Patents on Anti-Cancer Drug Discovery, 2008, 3, 1-13. Tyndall, J.D.A., Pattenden, L.K., Reid, R.C., Hu, S., Alewood, D., Alewood, P.F., Walsh, T., Fairlie, D.P. & Martin, J.L. (2008). Crystal structures of highly constrained substance and hydrolysis products bound to HIV-1 protease. Implications for the catalytic Mechanism. Biochemistry 2008, 47, 3736-3744. Wang, J., Jiang, Y., Wang, Y., Tang, Y., Teng., Fawcett, J.P., Kong, J. & Gu, J. (2008). A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies. Science Direct Journal of Pharmaceutical and Biomedical Analysis 47 (2008) 985-989. Wiranidchapong, C., Tucker, I.G., Rades, T & Kulvanich, P. (2008). Miscibility and interactions between 17β-estradiol and eudragit® RS in solid dispersion. Journal of Pharmaceutical Sciences. Woodland, C., Huang, T.T., Gryz, E., Bendayan, R. & Fawcett, J.P. (2008). Expression, activity and regulation of CYP3A in human and rodent brain. Informa healthcare, Drug Metabolism Reviews, 40: 149-168, 2008. Yan, T., Li, H., Deng, L., Guo, Y., Weisong, Y., Fawcett, P., Zhang, D., Cui, Y & Gu, J. (2008). Liquid chromatographic-tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma. Journal of Pharmaceutical and Biomedical Analysis 48, 1225-1229. Yan, Li., Fawcett, P., Zhang, H. & Tucker, I. (2008). Transport and metabolism of some cationic ubiquinone antioxidants (MitoQn) in Caco-2 cell monolayers. European Journal of Drug Metabolism and Pharmacokinetics 2008 Vol. 33 No. 4 pp. 199-204. Yang, Y., Li, H., Gao, K., Liu, M., Sun, Y., Yan, T., Fawcett, J.P., Cui, Y. & Gu, J. (2008). Simultaneous quantitation of dexamethasone and palmitate dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry. Science Direct Journal of Chromatography B, 862 (2008) 119-124. Yeo, T.W., Lampah, D.A., Gitawati, R., Tjitra, E., Kenangalem, E., Granger, D.L., Weinberg, J.B., Lopansri, B.K., Price, R.N., Celermajer, D.S., Duffull, S.B. & Anstey, N.M. (2008). Safety profile of L-Arginine Infusion in moderately severe falciparum malaria. PLoS ONE June 2008 Vol 3 Issue 3. Yeo, T.W., Lampah, D.A., Gitawati, R., Tjitra, E., Kenangalem, E., McNeil, Y.R., Darcy, C.J., Granger, D.L., Weinberg, J.B., Lopansri, B.K., Price, R.N., Duffull, S.B., Celermajer, D.S. & Anstey, N.M.(2008). Recovery of Endothelial Function in Severe Falciparum Malaria: Relationship with Improvement in Plasma L-Arginine and Blood Lactate Concentrations. The Journal of Infectious Diseases 2008:198. Yeo, T.W., Lampah, D.A,, Gitawati, R., Tjitra, E., Kenangalem, E., Piera, K., Price, R.N., Duffull, S.B., Celermajer, D.S. & Anstey, N.M. (2008) Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. PNAS (2008) 105(44 ): 17097-17102. Yeo, T.W., Rooslamiati, I., Gitawati, R., Tjitra, E., Lampah, D.A., Kenangalem, E., McNeil, Y.R., Price, R.N., Anstey, N.M. & Duffull, S.B. (2008). 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Chapter in Book Baxter, G. D. (2008). “Low-intensity laser therapy. Electrotherapy. In: Evidence-Based Practice. T. Watson, Churchill Livingstone Elsevier: 161-177.

Journal – Research Article Abbott, H. J. (2007) “The validity of manual examination for assessing patients with neck pain.” New Zealand Journal of Physiotherapy, 35(2): 86. Abbott, H. J. (2008) “Commentary: Non-specific neck pain: predicting poor recovery?” Physical Therapy Reviews, 13(1): 69-70 Abbott, H. J. (2008) “Invited Commentary: Spinal manipulative therapy for acute low back pain.” The Journal of Manual and Manipulative Therapy, 16(3): 204-205. Abbott, H. J. (2008) “On “Intertester reliability and validity of the motion of assessments…” Landel et al. Phys Ther. 2008, 88:43-40” Physical Therapy, 88(4): 536. Baxter, G. D., Basford, J. R. (2008). “Low level laser therapy: current status.” Focus on Alternative and Complementary Therapies 13(1): 11-13. Baxter, G. D. (2008). Commentary: “Auriculotherapy: effective in chronic and recurrent low back pain in the elderly?” Complementary Therapies in Medicine 16: 28 35. Beilby, J., Mulligan, H. (2008). “Deep vein thrombosis and heterotopic ossification following spinal cord injury - a clinical perspective for physiotherapists.” New Zealand Journal of Physiotherapy 36(1): 7-14. Carman, A. (2008). “Functional muscle model parameters and the length-tension relationship.” Journal of Biomechanics – Congress of the European Society of Biomechanics, Lucerne, Switzerland. Claydon, L., Chesterton, L. S., et al. (2008). “Effects of simultaneous dual-site TENS stimulation on experimental pain.” European Journal of Pain 12(6): 696-704. Donovan, K., Lord, S., et al. (2008). “Mobility beyond the clinic: the effect of environment on gait and its measurement in community-ambulant stroke survivors.” Clinical Rehabilitation 22: 556-563. Erhart, J. C., Muendermann, A., et al. (2008). “A variable-stiffness shoe lowers the knee adduction moment in subjects with symptoms of medial compartment knee osteoarthritis.” Journal of Biomechanics 41: 2720-2725. Erhart, J., Muendermann, A., et al. (2008). “Predicting changes in knee adduction moment due to load-altering interventions from pressure distribution at the foot in healthy subjects.” Journal of Biomechanics 41(14): 2989-2894. Fullen, B. M., Baxter, G. D., et al. (2008). “Doctors’ attitudes and beliefs regarding acute low back pain management: A systematic review.” Pain 136(3): 388-396. Fullen, B. M., Doody, C., et al. (2008). “Chronic low back pain: non-clinical factors impacting on management by Irish doctors.” Irish Journal of Medical Science 177: 257 263. Gregory, D. E., Milosavljevic, S., et al. (2008). “An examination of shoulder kinematics and kinetics when using a commercial trunk harness while sheep shearing.” Applied Ergonomics 39: 29-35. Hefford, C. (2008). “McKenzie classification of mechanical spinal pain: Profile of syndromes and directions of preference.” Manual Therapy 13(1): 75-81. Hefford, C., Lodge, S., et al. (2008). “Measuring patient-specific outcomes in musculoskeletal clinical practice: a pilot study.” New Zealand Journal of Physiotherapy 36(2): 41-48. Hokowhitu, B., Sullivan, S. J., et al. (2008) “Rugby culture, ethnicity and concussion.” MAI Review Volume, 1-9 DOI: Horton, S. J., Abbott, H. J. (2008). “A novel approach to managing graduated return to spinal loading in patients with low back pain using the Spineangel® device: a case series report.” New Zealand Journal of Physiotherapy 36(1): 22-28. Kennedy, S., Baxter, G. D., et al. (2008). “Acupuncture for acute non-specific low back pain: A pilot randomised non- penetrating sham controlled trial.” Complementary Therapies in Medicine 16: 139-146. McDonough, S. M., Liddle, S. D., et al. (2008). “Exercise and manual auricular acupuncture: a pilot assessor-blind randomised controlled trial. (The acupuncture and personalised exercise programme (APEP) trial).” BMC Musculoskeletal Disorders 9(31). Milosavljevic, S., Pal, P., et al. (2008). “Kinematic and temporal interactions of the lumbar spine and hip during trunk extension in healthy male subjects.” European Spine Journal 17: 122-128. Muendermann, A., Asay, J., et al. (2008). “Implications of increased medio-lateral trunk sway for ambulatory mechanics.” Journal of Biomechanics 41: 165-170. Muendermann, A., Dyrby, C. O., et al. (2008). “In vivo knee loading characteristics during activities of daily living as measured by an instrumented total knee replacement.” Journal of Orthopaedic Research 26(9): 1167-1172. Quinn, F., Hughes, C. M., Baxter, G. D. (2008). “Reflexology in the management of low back pain: A pilot randomised controlled trial.” Complementary Therapies in Medicine 16(1): 3-8. Skinner, M. (2008). “Review - Pagliarulo M. 2007. Introduction to Physical Therapy. 3rd Edition. St Louis, MO: Mosby Elsevier. 387 pp.” Physical Therapy Reviews 13(2 ): 143. Smith, C., Hale, L., Olson, K., Schneiders, A. G. (2008). “How does exercise influence fatigue in people with multiple sclerosis?” Disability and Rehabilitation 3: 1-8. Sole, G., Milosavljevic, S., et al. (2008). “Running-related hamstring injuries: a neuromuscular approach.” Physical Therapy Reviews 13(2): 102-110.

Division of HEALTH SCIENCES 237 Sullivan, S. J., Schneiders, A. G., et al. (2008). “Physiotherapists’ use of information in identifying a concussion: an extended Delphi approach.” British Journal of Sports Medicine 42: 175-177. Tumilty, S., Munn, J., et al. (2008). “Laser Therapy in the Treatment of Achilles Tendinopathy: A pilot study.” Photomedicine and Laser Surgery 26(1): 25-30. Tulloch, E., Phillips, C. (2008). “Chronic fatigue syndrome: a possible role of mechanical treatment? A case study.” Physical Therapy Reviews 13(2): 111-118.

Journal – Other Abbott, H. J. (2007) “Letters to the Editor.” The Spine Journal, 7: 384-385 Abbott, H. J. (2008) “Editorial.” New Zealand Journal of Physiotherapy, 36(2): 39-40. Abbott, H. J. (2008) “Editorial: Autonomy and the future of (speaking about) physiotherapy in New Zealand.” New Zealand Journal of Physiotherapy, 36(3): 109-110.

238 RESEARCH REPORT 2007/2008 APPENDIX 3: py ysiothera School of Ph Administration School of Pharmacy e y Divisional Office Dentistr Faculty of y y & macology ysiology unology al Biology Ph Anatom xicology of To uctur & & Imm Vice Chancellor Otago School of Medical Sciences Str Dept Dept of o Dept of Biochemistr Dept of Microbiology Dept of Phar Pr (Health Sciences) & e & al Med entiv omens’ athology Psych W actice of Pr Medicine gical Sciences Division of Health Sciences Organisation Structur Social Medicine Sur Dept of Gener Childrens’ Health Dept Dept of Medical & Dept of P Dunedin School of Dept of Dept of Prev o, ics al y & Med ger Faculty of Medicine aediatr athology & Psych actice ellington of Pr W ersity of Otag Anaesthesia Dept of O & G and Child Health Dept of Gener Dept of Medicine Dept Dept of P Dept of Sur Molecular Medicine Dept of Pub Health Dept of P Univ & o, y g ics Med ch ger actice Sur th athology aediatr al Pr P Psych Anaesthesia Or of of of Musc Med ersity of Otag Christchur Dept of O & G Dept of Sur ept Dept of Medicine Dept Dept Dept of P & Gener Dept of Pub Health D Dept of Univ

Division of HEALTH SCIENCES 239 240 RESEARCH REPORT 2007/2008 RESEARCH REPORT 2007-2008 DIVISION OF HEALTH SCIENCES

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