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Jan. 29, 2021 THIS FEBRUARY, ‘THE VIEW’ CELEBRATES BLACK HISTORY MONTH BY HONORING PIONEERS AND MODERN-DAY TRAILBLAZERS Anthony Anderson, Brandy, Dr. Ibram X. Kendi, Van Jones, Hot Topics and More on ABC’s ‘The View,’ Feb. 1-5 Honored with the Daytime Emmy® Award for Outstanding Informative Talk Show and delivering its most-watched season in 7 years, “The View” (11:00 a.m.–12:00 p.m. EST) is a priority destination for our guests and must-see viewing for our loyal fans with up-to-the-minute Hot Topics, tackling the important conversations and sharing passionate opinions. “The View,” now in season 24, is the place to be heard with live broadcasts five days a week. Hilary Estey McLoughlin serves as senior executive producer with Brian Teta as executive producer. “The View” is directed by Sarah de la O. For breaking news and updated videos, follow “The View” (@theview) and Whoopi Goldberg (@whoopigoldberg), Joy Behar (@joyvbehar), Sara Haines (@sarahaines), Sunny Hostin (@sunny), Meghan McCain (@meghanmccain) and Ana Navarro (@ananavarro) on Twitter. Scheduled guests for the week of FEB. 1-5 are as follows (subject to change): Monday, Feb. 1 – Anthony Anderson (ABC’s “black-ish”) Tuesday, Feb. 2 – Dr. Ibram X. Kendi (book, “Four Hundred Souls”) Wednesday, Feb. 3 — Day of Hot Topics Thursday, Feb. 4 — Brandy (album, “B7”) Friday, Feb. 5 — Van Jones (“The Reunited States”) LINK: http://bit.ly/3r4lXPn TWEET: https://ctt.ac/fC2m0 ABC Media Relations Lauri Hogan (212) 456-6358 [email protected] Follow “The View” (#theview) on Instagram, Twitter and Facebook. “The View” is now available on a podcast. Listen to the full show for free on Apple Podcasts or on your favorite podcast app every weekday afternoon. For more information, follow ABC News PR on Facebook, Twitter and Instagram. -- ABC -- .

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Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses
Published OnlineFirst July 12, 2021; DOI: 10.1158/1535-7163.MCT-21-0228 MOLECULAR CANCER THERAPEUTICS | SMALL MOLECULE THERAPEUTICS Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses Bjorn€ Stratenwerth1, Susanne M. Geisen2, Yang He1, Lea Beltzig1, Shana J. Sturla2, and Bernd Kaina1 ABSTRACT ◥ Temozolomide (TMZ) is a DNA-methylating agent used in cellular response, also increased linearly, without a threshold. Using cancer chemotherapy, notably for glioblastoma multiforme (GBM), a dose of 20 mmol/L, which is achievable in a therapeutic setting, we where it is applied as a front-line drug. One of the DNA alkylation determined that 14,000 adducts give rise to 32 DSBs (gH2AX foci) in 6 6 products of TMZ is the minor lesion O -methylguanine (O MeG), A172 cells. This leads to 12% cell death and 35% of cells entering 6 which is responsible for nearly all genotoxic, cytotoxic, and cyto- senescence. In LN229 cells, 20 mmol/L TMZ induced 20,600 O MeG static effects induced in the low-dose range relevant for cancer adducts, 66 DSBs (gH2AX foci), 24% apoptosis, and 52% senes- 6 therapy. Here, we addressed the question of how many O MeG cence. The linear dose response and the genotoxic and cytotoxic adducts are required to elicit cytotoxic responses. Adduct quanti- effects observed at therapeutically relevant dose levels make it very 6 fication revealed that O MeG increases linearly with dose. The same likely that the TMZ target concentration triggers a significant was observed for DNA double-strand breaks (DSB) and p53ser15.
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From Sissy to Sickening: the Indexical Landscape of /S/ in Soma, San Francisco
From sissy to sickening: the indexical landscape of /s/ in SoMa, San Francisco Jeremy Calder University of Colorado, Boulder [email protected] ABSTRACT: This paper explores the relation between the linguistic and the visual in communicating social meaning and performing gender, focusing on fronted /s/ among a community of drag queens in SoMa, San Francisco. I argue that as orders of indexicality (Silverstein 2003) are established, linguistic features like fronted /s/ become linked with visual bodies. These body-language links can impose top-down restrictions on the uptake of gender performances. Non-normatively gendered individuals like the SoMa queens embody cross-modal figures of personhood (see Agha 2003; Agha 2004) like the fierce queen that forge higher indexical orders and widen the range of performative agency. KEY WORDS: Indexicality, performativity, queer linguistics, gender, drag queens 1 Introduction This paper explores the relation between the linguistic and the visual in communicating social meaning. Specifically, I analyze the roles language and the body play in gender performances (see Butler 1990) among a community of drag queens and queer performance artists in the SoMa neighborhood of San Francisco, California, and what these gender performances illuminate about the ideological connections between language, body, and gender performativity more generally. I focus on fronted /s/, i.e. the articulation of /s/ forward in the mouth, which results in a higher acoustic frequency and has been shown to be ideologically
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Cuddle Up! America's Coziest Fireplaces U.S
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Independent Voters
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The View Listings
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