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May 7, 2021 BEBE REXHA, STACEY ABRAMS, JAKE TAPPER, DR. SANJAY GUPTA, HOT TOPICS AND MORE ON ABC’S ‘THE VIEW,’ MAY 10-14 Honored with the Daytime Emmy® Award for Outstanding Informative Talk Show and delivering its most-watched season in six years, “The View” (11:00 a.m.–12:00 p.m. EDT) is a priority destination for our guests and must-see viewing for our loyal fans with up-to-the-minute Hot Topics, tackling the important conversations and sharing passionate opinions. “The View,” now in season 24, is the place to be heard with live broadcasts five days a week. “The View” is executive produced by Brian Teta and directed by Sarah de la O. For breaking news and updated videos, follow “The View” (@theview) and Whoopi Goldberg (@whoopigoldberg), Joy Behar (@joyvbehar), Sara Haines (@sarahaines), Sunny Hostin (@sunny), Meghan McCain (@meghanmccain) and Ana Navarro (@ananavarro) on Twitter. Scheduled guests for the week of MAY 10-14 are as follows (subject to change): Monday, May 10 – Bebe Rexha (album, “Better Mistakes”); “View Your Deal” with hottest items at affordable prices Tuesday, May 11 – Stacey Abrams (author, “While Justice Sleeps”) Wednesday, May 12 — Jake Tapper (“The Devil May Dance”); “The View” celebrates National Nurses Week with Carla Brown from Baton Rouge, Louisiana Thursday, May 13 — Dr. Sanjay Gupta (“Race for a Vaccine”) Friday, May 14 — Day of Hot Topics LINK: https://bit.ly/3vMTBLW TWEET: https://ctt.ac/O9Va7 ABC Media Relations Lauri Hogan (212) 456-6358 [email protected] Follow “The View” (#theview) on Instagram, Twitter and Facebook. “The View” is now available on a podcast. Listen to the full show for free on Apple Podcasts or on your favorite podcast app every weekday afternoon. For more information, follow ABC News PR on Facebook, Twitter and Instagram. -- ABC -- .

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Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses
Published OnlineFirst July 12, 2021; DOI: 10.1158/1535-7163.MCT-21-0228 MOLECULAR CANCER THERAPEUTICS | SMALL MOLECULE THERAPEUTICS Molecular Dosimetry of Temozolomide: Quantification of Critical Lesions, Correlation to Cell Death Responses, and Threshold Doses Bjorn€ Stratenwerth1, Susanne M. Geisen2, Yang He1, Lea Beltzig1, Shana J. Sturla2, and Bernd Kaina1 ABSTRACT ◥ Temozolomide (TMZ) is a DNA-methylating agent used in cellular response, also increased linearly, without a threshold. Using cancer chemotherapy, notably for glioblastoma multiforme (GBM), a dose of 20 mmol/L, which is achievable in a therapeutic setting, we where it is applied as a front-line drug. One of the DNA alkylation determined that 14,000 adducts give rise to 32 DSBs (gH2AX foci) in 6 6 products of TMZ is the minor lesion O -methylguanine (O MeG), A172 cells. This leads to 12% cell death and 35% of cells entering 6 which is responsible for nearly all genotoxic, cytotoxic, and cyto- senescence. In LN229 cells, 20 mmol/L TMZ induced 20,600 O MeG static effects induced in the low-dose range relevant for cancer adducts, 66 DSBs (gH2AX foci), 24% apoptosis, and 52% senes- 6 therapy. Here, we addressed the question of how many O MeG cence. The linear dose response and the genotoxic and cytotoxic adducts are required to elicit cytotoxic responses. Adduct quanti- effects observed at therapeutically relevant dose levels make it very 6 fication revealed that O MeG increases linearly with dose. The same likely that the TMZ target concentration triggers a significant was observed for DNA double-strand breaks (DSB) and p53ser15.
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Cuddle Up! America's Coziest Fireplaces U.S
Video Live Menu LOG IN Shows Good Morning America Good Morning America World News Tonight World News Tonight Nightline Nightline 20/20 20/20 This Week This Week The View The View What Would You Do? What Would You Do? ABC News Features ABC News Features Cuddle Up! America's Coziest Fireplaces U.S. ABC News Features Font SizesPrint View All Politics International EBnyt LeErNtaAi nKAmTZe,n JtustLuxe.com Lifestyle HFeba. l4th, 2013 Virtual Reality Investigative Technology WIt'esa stleherting, it's freezing, it's Sspnoorwtsing…and we're all tired of it. PWriev awcaynt P oal iccoyzPyr isveaacty ne Poarli cay warm, Ycoruacr kClingA P fririvea –c yp rReifgehratsblyYo uorne C Aw itPhrivacy Rights Chhoitl dtoreddyn's sOenrvliicne aPnd rivasocym PeolicyChildren's Online Privacy Policy Interest-Based AdsInterest-Based Ads delicious desserts. Just in time for Terms of UseTerms of Use Cthoen tBaigct Chill UsCaond ntaVcat leUnts ine's around YOU MIGHT ALSO LIKE... Ytahheo coo!r-neABr,C h eNrew's sa Ngaelletwroyr okf | © 2018 ABC News Internet Ventures. All rights reserved. America's coziest hotel and Search Headlines, News and Video... restaurant firesides – from the iconic Bowery Hotel in Manhattan Gregory Goode to the snowy Rocky Mountain peaks. Part owner of Marvin Amid public triumph, Gaye song sues Ed private turmoil for Triple Creek Ranch, Darby, Mont. The Bitterroot Mountain view is half the pleasure from this fire-warmed I scream, you Which Travel Card lobby lookout in a premiere scream: Jury to settle Has The Most Montana luxury lodge. The other Recommended by half comes from the luxury-included hospitality, personalized service, and cozy furnishings that make you PHOTO GALLERIES feel like you're in your BFF's Triple Creek Ranch mountain lodge -- and your BFF's a billionaire.
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Meghan Mccain the View Contract
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On the Street
Upcoming Events On the Street Winter’s Eve at Lincoln Square “I love the neighborhood. I never think of safety in this area. I was here for the opening of Lincoln Center Out Monday, November 30th, 5:30 – 9:00 p.m. of Doors and listened to The Barber of Seville.” Broadway from Time Warner Center to 68th Street — Jeanne Fischer, Upper West Side resident Celebration begins with a Neighborhood Tree Lighting Ceremony at Dante Park Broadway at 63rd Street “We pick up litter and sweep crosswalks. We shovel www.WintersEve.org and salt in the winter. I tell my men, you gotta keep it clean! People compliment us. They say, ‘thank you for doing such a wonderful job.’” — Paul McDonald, Holiday Market at Columbus Circle Junior Team Leader, Green Keepers December 2nd – 24th, 10:00 a.m. – 8:00 p.m. SW entrance to Central Park www.urbanspace.com/holidaymarkets.html “I wish the Green Market were here every day. I used to be a chef — food is my passion. If I didn’t have three children, I’d stay here all day long!” — Maria Daou, Upper West Side resident The Lincoln Square District Management Association, Inc. FIRST CLASS 1841 Broadway, Suite 1112 U.S. POSTAGE New York, NY 10023 PAID New York, NY Permit Number 3536 lincolnsquarebid.org Call us at 212.581.3774 for your free commemorative Winter’s Eve cap! Supplies Limited It’s all here! neighborhood news neighborhood news Fall/Winter 2009 Lincoln Square Kick Starts the Holiday Season on November 30th! Hot Topics ave you ever been to district will be buzzing with activi- GOURMET GARAGE at 155 Winter’s Eve at Lincoln ties, performances, marching West 66th Street has arrived! A H Square, New York City’s bands, and holiday cheer for stunning array of colorful fruits and largest outdoor holiday festival? children and adults.
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