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(12) United States Patent (10) Patent No.: US 9,616,124 B2 Nimitz (45) Date of Patent: Apr

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(12) United States Patent (10) Patent No.: US 9,616,124 B2 Nimitz (45) Date of Patent: Apr USOO961 6124B2 (12) United States Patent (10) Patent No.: US 9,616,124 B2 NimitZ (45) Date of Patent: Apr. 11, 2017 (54) ANTIVIRAL SUPPLEMENT COMPOSITIONS Buhner, S., Herbal Antivirals. North Adams, MA: Storey Publish AND METHODS OF USE ing, 2013, pp. 22-60. Williams, J.E., Viral Immunity. Charlottesville, VA. Hampton 71) Applicant: Jonathan S. Nimitz, Albuquerque, NM Roads Publishing, 2002, pp. 300-318. pp Cuerd Williams, J.E., Beating the Flu. Charlottesville, VA. Hampton (US) Roads Publishing, 2002, pp. 95-113. McCutcheon, A.R. et al. Antiviral screening of British Columbian (72) Inventor: Jonathan S. Nimitz, Albuquerque, NM medicinal plants. Journal of Ethnopharmacology Dec. 1, (US) 1995:49(2): 101-10. Mukhtar, M. et al., Antiviral potentials of medicinal plants, Virus *) Notice: Subject to anyy disclaimer, the term of this Research 131 (2008) 111-120. patent is extended or adjusted under 35 Instant Immunity. Printed Oct. 7, 2014. "Instant Immunity: How it U.S.C. 154(b) by 0 days. Works” http://www.instantimmunity.com/ihow. Shopfagen.com. Printed Oct. 7, 2014. "Loviral product description (21) Appl. No.: 14/333,645 and details' http://www.shopfagen.com/catalog/loviral-60-softgels. html. Vitamins Because Your Worth It. Printed Oct. 7, 2014. "Immune (22) Filed: Jul. 17, 2014 Defense Advantage” http://www.doctorvitaminstore.com/8077 ImmuneDefensePg2.html. (65) Prior Publication Data Herb Pharm. Printed Oct. 7, 2014. “Virattack” https://www.herb US 2016/OO15762 A1 Jan. 21, 2016 pharm.com/store/product info.php?products id=241. Rockwell Nutrition. Printed Oct. 7, 2014. "Astragalus Combination #1 by Genestra' http://www.rockwellnutrition.com/astragalus-com (51) Int. Cl. bination-1-by-genestra.htmli.VDRmYr67b4c. A6 IK33/30 (2006.01) Planetary Herbals. Printed Oct. 7, 2014. “Yin Chiao-Echinacea A6 IK 45/06 (2006.01) Complex” http://www.planetaryherbals.com/products/print/ A6 IK 36/185 (2006.01) GP1564f. A6 IK3I/76 (2006.01) Acupuncture Atlanta. Printed Oct. 7, 2014. "Astra Isatis” http:// A6 IK 36/254 (2006.01) www.acuatlanta.net/health-concerns-astra-isatis-270-count-p- 17676.html. (52) U.S. Cl. Golden Needle. Printed Oct. 7, 2014. "Isatis 6' http://www.golden CPC ............ A61K 45/06 (2013.01); A61 K3I/716 needleonline.com/Isatis-6-100-tablets.html. (2013.01); A61K 33/30 (2013.01); A61 K iHerb.com. Printed Oct. 7, 2014."Swedish Herbal Institute Kan Jang Plus' http://www.iherb.com/Swedish-Herbal-Institute-Kan 36/185 (2013.01); A61K 36/254 (2013.01) Jang-Plus-Immune-Support-Formula-30-Capsules/36207. (58) Field of Classification Search Generationrescue.org. Printed Oct. 7, 2014. “Vira Stop 2X” https:// None www.generation rescue.org/assets/Grant-Resources/RFG-3- See application file for complete search history. Vira Stop2x.pdf. Tailor Made Nutrition. Printed Oct. 7, 2014. “NuMedica Immunographis Supplement Facts' http://www.tallormadenutrition. (56) References Cited com/shop? immunographis-p-11333. Amazon.com UK. Printed Oct. 7, 2014. "Hawaiipharm Immune U.S. PATENT DOCUMENTS Care Liquid Extract Tincture” http://www.amazon.co.uk/ HawaiiPharm-Immune-Care-Liquid-Extract/dp/B00A8FEC1A. 6,596,313 B2 7/2003 Rosenbloom Hospitalopedia. Printed Oct. 7, 2014. “Viro Plus” http:// 6,793,942 B2 9, 2004 Gelber hospitalopedia.com/viro-plus. 6,827,945 B2 12/2004 Rosenbloom Four Winds Nutrition. Printed Oct. 7, 2014. “Virustat” http://www. 7,579,024 B2 8/2009 Morrissey webnat.com/proddetail.asp?prod=virustat. 7,682,616 B2 3/2010 Rangel HerbsPro. Printed Oct. 7, 2014. “Lomatium Osha Throat Spray” 7,867,523 B2 1/2011 Vanterpool http://www.herbspro.com/lomatium-osha-throat-spray-32029.html. 8,637,094 B2 1/2014 Kiani ITM Online. Printed Oct. 7, 2014. "Shuanghuanglian: Potent Anti 8,697,670 B2 4/2014 Remmereit Infection Combination of Lonicera, Forsythia, and Scute” http:// 8,703,174 B2 4/2014 Hurwitz www.itmonline.org/arts/shuang.htm. 2002/011 1382 A1* 8, 2002 Cui ...................... A61K 31,235 514,533 (Continued) 2004/0076641 A1 * 4/2004 Kershenstine, Jr. ... A23L 1/3002 424, 19515 2008/0219964 A1* 9, 2008 Keefe ....................... A23L 1.30 Primary Examiner — Terry A. McKelvey 424.942 Assistant Examiner — Catheryne Chen 2009/0060879 A1* 3/2009 Clymer ............ A61K 31,592 (57) ABSTRACT 424,934 2010/O112096 A1 5, 2010 Herrmann The present invention relates to the field of dietary supple 2010/0113373 A1 5/2010 Phillips ments, and in particular to antiviral compositions and meth ods of use. Compositions are described involving various OTHER PUBLICATIONS combinations of Andrographis, Astragalus, Eleuthero, Isa Heikkinen, T. et al., The common cold. Lancet. 2003:361:51-9. tis, Lomatium, Pelargonium, Sambucus, Scute, and/or Zinc, Fendrick, A.M., Viral respiratory infections due to rhinoviruses: optionally with additional components. These combinations current knowledge, new developments. American Journal of Thera of Supplements synergistically reduce both severity and peutics 2003:10:193-202. duration of viral infections, including in particular colds and Lee, R. et al., Flu for You? The Common Cold, Influenza, and influenza, as well as providing additional benefits. Traditional Medicine, Explore, May 2006, vol. 2, No. 3. pp. 252-255. 24 Claims, No Drawings US 9,616,124 B2 Page 2 (56) References Cited Novick, S.G., et al. How does zinc modify the common cold? Clinical observations and implications regarding mechanisms of action. Medical Hypotheses 1996:46:295-302. OTHER PUBLICATIONS Farr, B.M., et al. Two randomized controlled trials of zinc gluconate Vitacost. Printed Oct. 7, 2014. "Metagenics Essential Defense Supplement Facts' http://www.vitacost.com/metagenics-essential lozenge therapy of experimentally induced rhinovirus colds. defense. Antimicrob. Agents Chemother, 1987:31:1183-7. Vitacost. Printed Oct. 7, 2014. “Gaia Herbs RapidRelief Quick Eby, G.A., Zinc lozenges as cure for the common cold. Medical Defense Supplement Facts' http://www.vitacost.com/gaia-herbs Hypotheses (2010) 74:482-92. rapidrelief-quick-defense-20-liquid-capsules-1. Hemila, H., Zinc lozenges may shorten the duration of colds: a Swanson Health Products. Printed Oct. 7, 2014. "Airborne immune systematic review. Open Respiratory Medical Journal (2011) 5:51 Support Supplement” http://www.Swansonvitamins.com/airborne 8. triple-pack-effervescent-Zesty-orange-30-tabs. Jin, M. et al., Structural features and biological activities of the 1st ChineseHerbs.com. Printed Oct. 7, 2014. “Serious Effective Cold polysaccharides from Astragalus membranaceus, Intl. J. of Biologi and Flu Tablets Zhong Gan Ling” http://www.listchineseherbs.com/ cal Macromolecules Mar. 2014, 64:257-266. Zhong gan ling.html. Moore, M., Medicinal Plants of the Pacific West. Santa Fe: Red Source Naturals. Printed Oct. 7, 2014. “Wellness Cold & Flu Crane Books, 1993, pp. 167-171. Supplement Facts' http://www.sourcenaturals.com/products/ Lizogub V.G. et al. Efficacy of a pelargonium sidoides preparation GP1339. in patients with the common cold. Explore (NY). Nov.-Dec. 2007; Source Naturals. Printed Oct. 7, 2014. “Wellness FluGuard Supple 3(6):573-84. ment Facts” http://www.sourcenaturals.com/products/GP2064. Nagai, T. et al. Antiviral activity of plant flavonoid, Source Naturals. Printed Oct. 7, 2014. “Wellness Shot Supplement 5.7.4"trihydroxy-8-methoxyflavone, from the roots of Facts” http://www.sourcenaturals.com/products/GP2386/. Scutellaria . Biological and Pharmaceut. Bull. 1995:18:295-299. Source Naturals. Printed Oct. 7, 2014. “Wellness Immune Chewable Baylor, N.W. et al., Inhibition of human T cell leukemia virus by the Supplement Facts' http://www.sourcenaturals.com/products/ plant flavonoid baicalin (7-glucuronic acid, 5,6-dihydroxyflavone). GP2304. J. of Infect. Diseases 1992; 165:433-7. Source Naturals. Printed Oct. 7, 2014. “Wellness Formula Tablet Wang, Q. et al. Zinc coupling potentiates anti-HIV-1 activity of Supplement Facts' http://www.sourcenaturals.com/products/ baicalin. Biochemical and Biophysical Research Communications GP1345. 324 (2004) 605-610. Source Naturals. Printed Oct. 7, 2014. “Wellness Formula Capsule Lee, K.Y., et al. Macrophage activation by polysaccharide isolated Supplement Facts' http://www.sourcenaturals.com/products/ from Astragalus membranaceus. International Immunopharmacol GP1345. ogy, vol. 5, Issues 7-8, Jul. 2005, pp. 1225-1233. NOW Foods. Printed Oct. 7, 2014. “Elderberry & Zinc Lozenges” Vogler, B.K., et al. The efficacy of ginseng. A systemic review of http://www.nowfoods.com/Elderberry-and-Zinc-90-Loz.htm. randomized clinical trials. European Journal of Clinical Pharma Vitacost. Printed Oct. 7, 2014. "Zand Elderberry Zinc Lozenges cology 1999:55:567-75. Supplement Facts” http://www.vitacost.com/zand-herbalozenge Steinmann, G.G. et al. Immunopharmacological in vitro effects of zinc-Sweet-elderberry. Eleutherococcus senticosus extracts. Arzneimittelforschung Jan. Umcka.com. Printed Oct. 7, 2014. “Umcka R. Elderberry Intensive 2001: 51(1) 76-83. Cold--Flu' http://www.umcka.com/ColdFlu? 15845-Umcka-Elder Bohn, B. et al. Flow-cytometric studies with eleutherococcus berry-Intensive-ColdFlu.aspx. senticosus extract as an immunomodulatory agent. Arzneimit Zakay-Rones, Z. et al. Randomized study of the efficacy and safety telforschung 1987; 37(II), 10: 1193-6. of oral elderberry extract in the treatment of influenza . J. Intl. Nagai, T. et al. In vivo anti-influenza virus activity of plant Medical Research (2004)32.2: 132-140. flavonoids possessing inhibitory activity for influenza virus Merluzzi, V.J. et al. Evaluation of zinc complexes on the replication sialidase. Antiviral Research 1992:19:207-217. of rhinovirus 2 in vitro. Research Communications in Chemical Pathology and Pharmacology 1989;66:425-40. * cited by examiner US 9,616,124 B2 1. 2 ANTIVIRAL SUPPLEMENT COMPOSITIONS CDC, the number of schooldays lost by kindergarten AND METHODS OF USE through 12th-grade students annually in the U.S. due to colds is about 22 million, and to flu about 38 million. Even CROSS-REFERENCES TO RELATED a 10% reduction in these losses would be highly significant APPLICATIONS and valuable. The present invention, if widely used, would allow a much greater reduction than this in both severity and Not applicable duration of colds and flu.
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