Low-Dose Oral Minoxidil for Hair Loss

Total Page:16

File Type:pdf, Size:1020Kb

Low-Dose Oral Minoxidil for Hair Loss University Teaching Trust Low-dose oral Minoxidil for hair loss Irving Building The Dermatology Centre 0161 206 9880 © G21021103W. Design Services, Salford Royal NHS Foundation Trust, All Rights Reserved 2021. Document for issue as handout. Unique Identifier: CS11(21). Review date: May 2023. What is oral minoxidil How is low-dose oral treatment? The licensed indication for minoxidil treatment given? People with heart problems Minoxidil is a tablet medication oral minoxidil is severe high Minoxidil is available as a (e.g. heart failure, angina originally used to treat high blood pressure unresponsive to 2.5mg tablet. To achieve the or recent heart attack), blood pressure. Interestingly, a standard treatment. correct dose of 0.625mg per phaeochromocytoma, acute porphyria or significant kidney side effect of this tablet was the Side effects of oral minoxidil day this tablet must be broken problems may not be suitable for development of increased body therapy are dose related and into quarters. A pill cutter this type of treatment. hair growth. include low blood pressure, will be supplied with the first prescription to enable easy This observation ultimately led increased heart rate and fluid cutting of the tablets. to the development of a topical retention (see page 3). Does it work? solution applied directly to the Only take one quarter tablet There is strong evidence that scalp to treat hair loss. Oral minoxidil for hair loss per day. topical minoxidil can increase Topical minoxidil (known as hair growth in male and female At Salford Royal, patients are Regaine®) is now licensed to treat pattern hair loss. considered eligible for oral male and female pattern hair Who can have oral The evidence for oral minoxidil minoxidil treatment if their hair loss and can be brought over the minoxidil treatment? is less strong but has been used loss has not responded to topical counter in most chemists. successfully in post-chemotherapy minoxidil or if these products are You should not have this hair loss, female pattern hair How it improves hair growth not tolerated. treatment if you are pregnant or is not fully understood but is trying to conceive. loss, fragile hair disorders and We use oral minoxidil at much probably due to increased blood alopecia areata. lower doses than those used to All women of childbearing flow to the hair roots. We see treat high blood pressure as this potential must use effective hairs growing for longer and Are there any other can still stimulate hair to grow contraception during the new hair starting to grow more but has a much lower risks of side treatment course and for 1 month treatment options quickly. effects. after to prevent pregnancy. available? In some people topical minoxidil A negative pregnancy test result Yes. There are a number of can cause dry and tangled hair is required before treatment can reported treatments for hair loss. with increased hair breakage, start. which can be an issue particularly Feel free to discuss what in fragile hair conditions. alternative treatment options are available with your Consultant. © G21021103W. Design Services, Salford Royal NHS Foundation Trust, 1 All Rights Reserved 2021. Document for issue as handout. 2 Unique Identifier: CS11(21). Review date: May 2023. Are there any risks or Do I need to change my What precautions should I complications? For safety, your doctor will need lifestyle in any way? take during treatment? Yes. Although the risk of side to monitor your pulse and blood We know that alcohol taken with If you notice any of the following effects is reduced by using a very pressure at each visit, check your oral minoxidil may increase the please stop taking the medication low dose, the following side blood tests regularly and may also risk of low blood pressure. and contact the department / effects are reported with oral perform a heart tracing (ECG). seek emergency advice: Therefore, we recommend you minoxidil: minimise your alcohol intake l Increased pulse / palpitations l Fluid retention (causing weight Can oral minoxidil be taken whilst on this treatment. Caffeine (>20 bpm higher than normal): gain and/or ankle swelling) with my other medication? containing products (e.g. Always check your pulse when caffeinated drinks / “Cold & Flu” resting l Increased heart rate (= fast Oral minoxidil is known to products) may increase the risk of pulse / palpitations) l Rapid weight gain (>2kg) or interact with a number of a rapid heart rate or palpitations. ankle swelling l Pericarditis / pericardial different medications. l effusion (causing chest pain In particular, it can cause Shortness of breath / chest and/or shortness of breath) significant reduction in blood What if I develop side pain l Low blood pressure (may pressure if given with other anti- effects that worry me? l Dizziness/ light-headedness / cause dizziness / fainting) hypertensive treatments. Before starting treatment you fainting l Increased body hair growth Always inform your doctor / other will be given our contact details. health care professionals that you You can contact us at any time l Skin rashes are taking oral minoxidil before during normal working hours to l Nausea and vomiting you start any new medication. obtain advice or to organise an urgent review if necessary. l Breast tenderness Alcohol intake may also lower If you develop a worrying side l Blood test abnormalities your blood pressure when taken with oral monoxidil. effect over the weekend, you may You may notice some increased need to seek medical advice from hair shedding at start of your local GP out of hours service. treatment. Do not worry, this is If you are unwell and require very common and usually settles urgent treatment you should within 6 weeks. attend your local Accident & Emergency department. © G21021103W. Design Services, Salford Royal NHS Foundation Trust, 3 All Rights Reserved 2021. Document for issue as handout. 4 Unique Identifier: CS11(21). Review date: May 2023. If you have problems Notes or other unexplained symptoms, please contact the department. Contact details The Dermatology Centre, Salford Royal NHS Foundation Trust, Stott Lane, Salford, M6 8HD. Dr Matthew Harries 0161 206 9880 [email protected] © G21021103W. Design Services, Salford Royal NHS Foundation Trust, 5 All Rights Reserved 2021. Document for issue as handout. 6 Unique Identifier: CS11(21). Review date: May 2023. © G21021103W. Design Services Salford Royal NHS Foundation Trust All Rights Reserved 2021 This document MUST NOT be photocopied University Teaching Trust Information Leaflet Control Policy: Unique Identifier: CS11(21) Review Date: May 2023 For further information on this leaflet, its references and sources used, please contact 0161 206 9880 Copies of this leaflet are available in other formats (for example, large print or easyread) upon request. Alternative formats may also be available via www.srft.nhs.uk/for-patients/patient-leaflets/ In accordance with the Equality Act we will make reasonable adjustments to enable individuals with disabilities to access this service. Please contact the service/clinic you are attending by phone or email prior to your appointment to discuss your requirements. Interpreters are available for both verbal and non-verbal (e.g. British Sign Language) languages, on request. Please contact the service/clinic you are visiting to request this. If you need this information leaflet translated, please telephone: 0161 206 0224 or Email: [email protected] Salford Royal is a smoke-free organisation including all buildings, grounds and car parks to improve our environment for patients, visitors and staff. For advice on quitting smoking contact 0161 206 1779. This is a teaching hospital which plays an important role in the training of future doctors. The part patients play in this process is essential to make sure that we produce the right quality doctors for all of our futures. If at any time you would prefer not to have students present please inform the doctor or nurses and this will not affect your care in anyway. Salford Royal NHS Foundation Trust If you would like to become a Foundation Trust Member Stott Lane, Salford, please visit: Manchester, M6 8HD www.srft.nhs.uk/for-members Telephone: 0161 789 7373 If you have any suggestions as to how this document could be improved in the future then please visit: www.srft.nhs.uk http://www.srft.nhs.uk/for-patients Salford Royal is committed to producing high quality, evidence based, functional consumer health and care information. To support this we apply the principles and quality statements of The Information Standard fully to ensure that our process for producing information follows best practice..
Recommended publications
  • Topically Applied Minoxidil in Baldness
    Review Topically Applied Minoxidil in Baldness ERVIN NOVAK,M.D., THOMASJ. FRANZ, M.D., JOHN T. HEADINGTON,M.D., AND RONALD C. WESTER,PH.D. From the Upjohn Company, Kalamazoo, Michigan, School idil and its metabolites can be removed by hemodi- of Medicine, University of Washington, Seattle, alysis. Washington, Medical School, University of Michigan, Ann Fluid retention and hypertrichosis are the most Arbor, Michigan, and School of Medicine and School of Pharmacy, University of California, San Francisco, California commonly occurring side effects of minoxidil. Hair regrowth in a patient with male pattern baldness was described in a case report of a hypertensive patient treated twice daily with 20 mg oral minoxidil.6 The Minoxidil, an orally administered, peripheral va- extensive hair regrowth continued after 10 months sodilator used to treat hypertension, causes hypertri- of therapy. New and increased hair growth as a side chosis in more than 80% of users. The drug reduces effect was also detected in an early clinical study elevated blood pressure by decreasing peripheral involving five of eight patients on oral minoxidil vascular resistance. Chemically, minoxidil is 2,4-di- therapy for 2 month^.^ Zappacosta' reported reversal amino-6-piperidinopyrimidine-3-oxide; it is soluble in of baldness in a patient on minoxidil for the treatment water to the extent of approximately 2 mg/ml, is of hypertension. more readily soluble in propylene glycol or ethanol, After the third week of therapy with oral minoxidil, and is nearly insoluble in acetone, chloroform, or hypertrichosis usually appears between the eyebrows ethyl acetate. Following oral administration of minox- and the hair line, in the malar and temporal areas, idil and in association with the reduction in peripheral on the backs of the arms, on the shoulders, and on vascular resistance, cardiac output is augmented, salt the legs.
    [Show full text]
  • Label-Free Cell Phenotypic Profiling Decodes the Composition And
    OPEN Label-free cell phenotypic profiling SUBJECT AREAS: decodes the composition and signaling POTASSIUM CHANNELS SENSORS AND PROBES of an endogenous ATP-sensitive Received potassium channel 28 January 2014 Haiyan Sun1*, Ying Wei1, Huayun Deng1, Qiaojie Xiong2{, Min Li2, Joydeep Lahiri1 & Ye Fang1 Accepted 24 April 2014 1Biochemical Technologies, Science and Technology Division, Corning Incorporated, Corning, NY 14831, United States of Published America, 2The Solomon H. Snyder Department of Neuroscience and High Throughput Biology Center, Johns Hopkins University 12 May 2014 School of Medicine, Baltimore, Maryland 21205, United States of America. Current technologies for studying ion channels are fundamentally limited because of their inability to Correspondence and functionally link ion channel activity to cellular pathways. Herein, we report the use of label-free cell requests for materials phenotypic profiling to decode the composition and signaling of an endogenous ATP-sensitive potassium should be addressed to ion channel (KATP) in HepG2C3A, a hepatocellular carcinoma cell line. Label-free cell phenotypic agonist Y.F. (fangy2@corning. profiling showed that pinacidil triggered characteristically similar dynamic mass redistribution (DMR) com) signals in A431, A549, HT29 and HepG2C3A, but not in HepG2 cells. Reverse transcriptase PCR, RNAi knockdown, and KATP blocker profiling showed that the pinacidil DMR is due to the activation of SUR2/ Kir6.2 KATP channels in HepG2C3A cells. Kinase inhibition and RNAi knockdown showed that the pinacidil * Current address: activated KATP channels trigger signaling through Rho kinase and Janus kinase-3, and cause actin remodeling. The results are the first demonstration of a label-free methodology to characterize the Biodesign Institute, composition and signaling of an endogenous ATP-sensitive potassium ion channel.
    [Show full text]
  • Acquired Hypertrichosis of the Periorbital Area and Malar Cheek
    PHOTO CHALLENGE Acquired Hypertrichosis of the Periorbital Area and Malar Cheek Caitlin G. Purvis, BS; Justin P. Bandino, MD; Dirk M. Elston, MD An otherwise healthy woman in her late 50s with Fitzpatrick skin type II presented to the derma- tology department for a scheduled cosmetic botulinum toxin injection. Her medical history was notable only for periodic nonsurgical cosmetic procedures including botulinum toxin and dermal fillers, and she was not taking any daily systemic medications. Duringcopy the preoperative assess- ment, subtle bilateral and symmetric hypertricho- sis with darker terminal hair formation was noted on the periorbital skin and zygomatic cheek. Uponnot inquiry, the patient admitted to purchas- ing a “special eye drop” from Mexico and using it regularly. After instillation of 2 to 3 drops per eye, she would laterally wipe the resulting excess Dodrops away from the eyes with her hands and then wash her hands. She denied a change in eye color from their natural brown but did report using blue color contact lenses. She denied an increase in hair growth elsewhere including the upper lip, chin, upper chest, forearms, and hands. She denied deepening of her voice, CUTIS acne, or hair thinning. WHAT’S THE DIAGNOSIS? a. acetazolamide-induced hypertrichosis b. betamethasone-induced hypertrichosis c. bimatoprost-induced hypertrichosis d. cyclosporine-induced hypertrichosis e. timolol-induced hypertrichosis PLEASE TURN TO PAGE E21 FOR THE DIAGNOSIS From the Department of Dermatology, Medical University of South Carolina, Charleston. The authors report no conflict of interest. Correspondence: Justin P. Bandino, MD, 171 Ashley Ave, MSC 908, Charleston, SC 29425 ([email protected]).
    [Show full text]
  • Guideline for Preoperative Medication Management
    Guideline: Preoperative Medication Management Guideline for Preoperative Medication Management Purpose of Guideline: To provide guidance to physicians, advanced practice providers (APPs), pharmacists, and nurses regarding medication management in the preoperative setting. Background: Appropriate perioperative medication management is essential to ensure positive surgical outcomes and prevent medication misadventures.1 Results from a prospective analysis of 1,025 patients admitted to a general surgical unit concluded that patients on at least one medication for a chronic disease are 2.7 times more likely to experience surgical complications compared with those not taking any medications. As the aging population requires more medication use and the availability of various nonprescription medications continues to increase, so does the risk of polypharmacy and the need for perioperative medication guidance.2 There are no well-designed trials to support evidence-based recommendations for perioperative medication management; however, general principles and best practice approaches are available. General considerations for perioperative medication management include a thorough medication history, understanding of the medication pharmacokinetics and potential for withdrawal symptoms, understanding the risks associated with the surgical procedure and the risks of medication discontinuation based on the intended indication. Clinical judgement must be exercised, especially if medication pharmacokinetics are not predictable or there are significant risks associated with inappropriate medication withdrawal (eg, tolerance) or continuation (eg, postsurgical infection).2 Clinical Assessment: Prior to instructing the patient on preoperative medication management, completion of a thorough medication history is recommended – including all information on prescription medications, over-the-counter medications, “as needed” medications, vitamins, supplements, and herbal medications. Allergies should also be verified and documented.
    [Show full text]
  • Ambetter 90-Day-Maintenance Drug List- 2020
    Ambetter 90-Day-Maintenance Drug List Guide to this list: What is Ambetter 90‐Day‐Maintenance Drug List? Ambetter 90‐Day‐Supply Maintenance Drug List is a list of maintenance medications that are available for 90 day supply through mail order or through our Extended Day Supply Network. How do I find a pharmacy that is participating in Extended Day Supply Network? To find a retail pharmacy that is participating in our Extended Day Supply Network please consult information available under Pharmacy Resources tab on our webpage. Alternatively, you can utilize our mail order pharmacy. Information on mail order pharmacy is available in Pharmacy Resources tab on our webpage. Are all formulary drugs covered for 90 day supply? No, certain specialty and non‐specialty drugs are excluded from 90 day supply. Please consult 90‐Day‐ Supply Maintenance Drug List for information if your drug is included. A Amitriptyline HCl Acamprosate Calcium Amlodipine Besylate Acarbose Amlodipine Besylate-Atorvastatin Calcium Acebutolol HCl Amlodipine Besylate-Benazepril HCl Acetazolamide Amlodipine Besylate-Olmesartan Medoxomil Albuterol Sulfate Amlodipine Besylate-Valsartan Alendronate Sodium Amlodipine-Valsartan-Hydrochlorothiazide Alendronate Sodium-Cholecalciferol Amoxapine Alfuzosin HCl Amphetamine-Dextroamphetamine Aliskiren Fumarate Anagrelide HCl Allopurinol Anastrozole Alogliptin Benzoate Apixaban Alosetron HCl Arformoterol Tartrate Amantadine HCl Aripiprazole Amiloride & Hydrochlorothiazide Armodafinil Amiloride HCl Asenapine Maleate Amiodarone HCl Aspirin-Dipyridamole
    [Show full text]
  • Study Protocol 7
    Title: Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia Protocol Number: 1308M40801 Study Drug: Gabapentin 6% Solution Principal Investigator: Maria Hordinsky, MD 612-625-8625 Study Team: Rehana Ahmed-Saucedo, MD, PhD Margareth Pierre-Louis, MD Elisabeth Hurliman, MD, PhD Trial Site: University of Minnesota, Department of Dermatology MMC 98 Minneapolis, MN 55455 Laboratory: University of Minnesota, Fairview Laboratory 516 Delaware St. Minneapolis, MN 55455 Masonic Clinical Research Unit MMC 405, 420 Delaware St. Minneapolis, MN 55455 Version Date: January 12, 2016 CONFIDENTIAL This is a University of Minnesota clinical research trial document that contains confidential information. It is intended solely for the recipient clinical investigator(s) and must not be disclosed to any other party. The material may be used only for evaluating or conducting clinical investigations; any other proposed use requires written consent from the University of Minnesota Department of Dermatology. Scarring Alopecia-Gabapentin Study Version 5 | Approved 01.28.2016 Page ii Table of Contents STUDY SUMMARY ................................................................................................................................. 1 1 INTRODUCTION ............................................................................................................................... 2 1.1 BACKGROUND .............................................................................................................................
    [Show full text]
  • Valproate-Induced Hair Loss: What to Tell Patients
    P earls Valproate-induced hair loss: What to tell patients Shailesh Jain, MD, MPH, ABDA, and Beth Beste, MS Teach patients s. B, age 29, has bipolar disorder may lead to low serum and liver tissue bio- that certain that is stabilized by valproate, 1,250 tinidase enzyme4; a major clinical manifes- supplements and Mmg/d. After 1 month of treatment, tation of biotin deficiency is alopecia. she shows scalp hair loss. She takes no other lifestyle changes medications and is distressed because she had 2 Tell patients to avoid taking valproate may reduce this never experienced such copious hair loss. Ms. during meals to prevent its chelating effect on usually temporary B’s blood valproate level is at a therapeutic food. The chelating effect of valproate makes side effect level. She wants to know if the hair loss will metals that facilitate hair growth, such as zinc be permanent and what she can do to stop it. and selenium, unavailable for absorption.5 Up to 28% of patients who take valproate suffer temporary alopecia.1,2 In most cases, 3 Recommend zinc and selenium supple- hair loss is associated with long-term valpro- ments, which can help stop further hair loss ate pharmacotherapy. Hair loss appears to and regenerate hair.5 be dose-related2 and may be more common in women than in men. Usually patients will 4 Suggest practical advice for hair care, in- report gradual but steady hair loss, com- cluding using soft brushes and mild sham- monly beginning 2 to 6 months after initiat- poos and avoiding dyes, heated curlers, and ing treatment.3 Complete hair loss is rare and hair dryers.
    [Show full text]
  • IEHP Dualchoice Cal Mediconnect Formulary Maintenance Drug List
    IEHP DualChoice Cal MediConnect (Medicare-Medicaid Plan) Formulary Maintenance Drug List The following formulary medications may be approvable up to a three-month supply. Certain medications on this list may require prior approval from the plan based on existing criteria before being covered. For coverage information please see our formulary located on our website. BRAND GENERIC STREGTH DOSAGE FORM ABACAVIR ABACAVIR SULFATE 300 MG TABLET ABACAVIR ABACAVIR SULFATE 20 MG/ML SOLUTION TRIUMEQ ABACAVIR SULFATE/DOLUTEGRAVIR 600-50-300 TABLET SODIUM/LAMIVUDINE ABACAVIR-LAMIVUDINE ABACAVIR SULFATE/LAMIVUDINE 600-300MG TABLET ABACAVIR-LAMIVUDINE- ABACAVIR SULFATE/LAMIVUDINE/ZIDOVUDINE 150-300 MG TABLET ZIDOVUDINE TYMLOS ABALOPARATIDE 80MCG/DOSE PEN INJCTR ORENCIA ABATACEPT 125 MG/ML SYRINGE ORENCIA CLICKJECT ABATACEPT 125 MG/ML AUTO INJCT ORENCIA ABATACEPT 50MG/0.4ML SYRINGE ORENCIA ABATACEPT 87.5MG/0.7 SYRINGE VERZENIO ABEMACICLIB 50 MG TABLET VERZENIO ABEMACICLIB 100 MG TABLET VERZENIO ABEMACICLIB 150 MG TABLET VERZENIO ABEMACICLIB 200 MG TABLET ABIRATERONE ACETATE ABIRATERONE ACETATE 500 MG TABLET ABIRATERONE ACETATE ABIRATERONE ACETATE 250 MG TABLET YONSA ABIRATERONE ACETATE, SUBMICRONIZED 125 MG TABLET CALQUENCE ACALABRUTINIB 100 MG CAPSULE ACAMPROSATE CALCIUM ACAMPROSATE CALCIUM 333 MG TABLET DR ACARBOSE ACARBOSE 25 MG TABLET ACARBOSE ACARBOSE 50 MG TABLET ACARBOSE ACARBOSE 100 MG TABLET ACEBUTOLOL HCL ACEBUTOLOL HCL 200 MG CAPSULE ACEBUTOLOL HCL ACEBUTOLOL HCL 400 MG CAPSULE ACETAZOLAMIDE ER ACETAZOLAMIDE 500 MG CAPSULE ER ACETAZOLAMIDE
    [Show full text]
  • Dialyzability of Medications During Intermittent Hemodialysis
    DialyzeIHD: Dialyzability of Medications During Intermittent Hemodialysis % Dialyzed % Dialyzed % Dialyzed % Dialyzed IHD Dosing; Administration IHD Dosing; Administration IHD Dosing; Administration IHD Dosing; Administration Timing Drug (Type of Drug (Type of Drug (Type of Drug (Type of Timing Around HD Session Timing Around HD Session Around HD Session Dialyzer) Timing Around HD Session Dialyzer) Dialyzer) Dialyzer) 0.25-0.5mg PO Q8H PRN, Insulin Aspart, Pentamidine 0 4mg/kg IV Q24-36H, Not recommended for use, Clonazepam N/A Reduce to 25-50% of normal dose Acarbose N/A Administer anytime during HD Insulin Detemir, Isethionate (N/A) Administer anytime during HD Administer anytime during HD N/A and titrate, Administer anytime Insulin Glargine, 0.1-0.4mg PO Q8-12H, during HD Normal dose and titrate based on 100-150mg PO Q12-24H, <5 Insulin Lispro Acebutolol N/A Clonidine Administer anytime during HD; No target free or corrected total Administer post-HD (Low Flux) Phenytoin Dose post-HD if hypotensive 75-300mg PO Q24H, (Low Flux) phenytoin level, Normal dose based on indication, 0 Administer anytime during HD Acetaminophen N/A 75mg PO Q24H, Irbesartan Administer anytime during HD; Dose Administer anytime during HD Clopidogrel N/A (N/A) Administer anytime during HD post-HD if hypotensive No 15-45mg PO Q24H, Pioglitazone 2.5-5mg/kg IV/PO Q24H, (N/A) Administer anytime during HD 40-60 250-500mg PO Q6H or 1-2g IV Q4- 100mg IV weekly to monthly, Acyclovir Administer post-HD over 60 Cloxacillin N/A Iron Dextran N/A (N/A) 6H, Administer anytime
    [Show full text]
  • Formulation of Sodium Valproate Nanospanlastics As a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia
    pharmaceutics Article Formulation of Sodium Valproate Nanospanlastics as a Promising Approach for Drug Repurposing in the Treatment of Androgenic Alopecia Farid. A. Badria 1,* , Hassan A. Fayed 2, Amira K. Ibraheem 3, Ahmed F. State 2 and Eman A. Mazyed 4 1 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 33516, Egypt 2 Department of Dermatology, Faculty of Medicine, Mansoura University, Mansoura 33516, Egypt; [email protected] (H.A.F.); [email protected] (A.F.S.) 3 Mansoura Dermatology and Leprosy Hospital, Mansoura 35511, Egypt; [email protected] 4 Department of Pharmaceutical Technology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh 33516, Egypt; [email protected] * Correspondence: [email protected]; Tel.: +20-100-1762927 Received: 12 August 2020; Accepted: 9 September 2020; Published: 11 September 2020 Abstract: Sodium valproate (SV) is an antiepileptic drug that is widely used in the treatment of different seizure disorders. The topical SV has a hair regenerative potential through activating the Wnt/β-catenin pathway and anagen phase induction. The aim of the current investigation was to fabricate nanospanlastics of SV for improving its dermal delivery by providing prolonged drug effect and increasing its permeability for treatment of androgenic alopecia (AGA). SV-loaded nanospanlastics were formulated according to 23 factorial design by ethanol injection method using a non-ionic surfactant (Span 60) and edge activators (EAs), such as Tween 80 and Cremophor RH 40, to explore the influence of different independent variables on entrapment efficiency (EE%) and percentage drug released after 12 h (Q12h) in order to choose the optimized formula using Design-Expert software.
    [Show full text]
  • HEB Minoxidil Topical Solution USP, 5% Drug Facts
    MINOXIDIL FOR MEN- minoxidil solution H E B ---------- HEB Minoxidil Topical Solution USP, 5% Drug Facts Active ingredient Minoxidil 5% w/v Purpose Hair regrowth treatment for men Use to regrow hair on the top of the scalp (vertex only, see pictures on side of carton) Warnings For external use only. For use by men only. Flammable: Keep away from fire or flame Do not use if • you are a woman • your amount of hair loss is different than that shown on the side of this carton or your hair loss is on the front of the scalp. Minoxidil topical solution 5% is not intended for frontal baldness or receding hairline. • you have no family history of hair loss • your hair loss is sudden and/or patchy • you do not know the reason for your hair loss • you are under 18 years of age. Do not use on babies and children. • your scalp is red, inflamed, infected, irritated, or painful • you use other medicines on the scalp Ask a doctor before use if you have heart disease When using this product • do not apply on other parts of the body • avoid contact with the eyes. In case of accidental contact, rinse eyes with large amounts of cool tap water. • some people have experienced changes in hair color and/or texture • it takes time to regrow hair. Results may occur at 2 months with twice a day usage. For some men, you may need to use this product for at least 4 months before you see results. • the amount of hair regrowth is different for each person.
    [Show full text]
  • Sodium Valproate Induced Alopecia: a Case Series
    DOI: 10.7860/JCDR/2017/28564.10658 Case Series Sodium Valproate Induced Alopecia: A Section Case Series Pharmacology SEREEN ROSE THOMSON1, VINAY MAMULPET2, SHALINI ADIGA3 ABSTRACT Drug induced alopecia may range from a barely detectable shedding to an irreversible baldness. Alopecia associated with valproate is a dose-dependent and reversible side effect. We hereby report, three cases of alopecia that occurred in patients who received sodium valproate for various neurological conditions. In all three cases, long term exposure of valproate therapy led to the development of alopecia which eventually resolved after dose reduction or discontinuation. The Naranjo’s causality assessment scale indicated valproate as the probable cause of the alopecia in all our patients. Keywords: Adverse drug reaction, Anticonvulsant, Hair loss, Naranjo’s scale CASE SERIES scalp examination there was non-scarring and bitemporal recession Sodium valproate was originally developed as an anti-epileptic and of hair. His 1st episode of GTCS was at the age of 15 years, when he nd later approved for its use in bipolar disorders, migraine prophylaxis was started on tablet phenytoin 500 mg twice a day. A 2 episode and off labelly in the treatment of alcohol dependence, bipolar of GTCS occurred the next year, when phenytoin was changed depression and aggression. Therefore, it is important to keep a to valproate 500 mg. Metabolic and other laboratory parameters watch at the common and uncommon Adverse Drug Reactions [{Fasting blood sugar–99 mg/dl (70-100 mg/dl), Total cholesterol- (ADR) occurring with this drug. Diffuse and non-scarring alopecia is 180 mg/dl (140-200 mg/dl), Triglycerides-142 mg/dl (60-150 mg/ one of the uncommon ADR associated with valproate and has to be dl), HDL-37 (40-65 mg/dl), LDL-114.6 mg/dl (50-130 mg/dl), looked into and treated with utmost caution.
    [Show full text]