BIN DENG Curriculum Vitae MGH/HST Athinoula A. Martinos Center for Biomedical Imaging 149 13th St., Suite 2280-B, Charlestown, MA, 02129 [email protected] (617) 726-9338

EDUCATION Syracuse University, Syracuse, NY Doctor of Philosophy, Bioengineering August 2012 Thesis: The role of fluorescence and human factors in quantitative transdermal blood and tissue analysis using NIR Raman spectroscopy Advisor: Prof. Joseph Chaiken Tianjin University, College of Precision Instrument & Optoelectronics Engineering, China Master of Science, Measuring and Testing Technology and Instrument March 2007 Thesis: Theoretical and experimental study on effective extraction of glucose specific signal in NIR spectroscopy Advisor: Prof. Kexin Xu

Bachelor of Science, Biomedical Engineering July 2004 Senior Thesis: Mechanical design and application of DOAS (differential optical absorption spectroscopy) system for atmospheric quality monitoring Advisor: Prof. Yan Wang

PROFESSIONAL POSITIONS 10/2012 – 10/2013 Application Scientist LighTouch Medical, Inc. 10/2013 – 03/2018 Research Fellow Massachusetts General Hospital Martinos Center for Biomedical Imaging 03/2018 – present Instructor Harvard Medical School Research Staff MGH – Martinos Center

RESEARCH EXPERIENCE >> Research Fellow, MGH Martinos Center for Biomedical Imaging October 2013 – March 2018 • Multi-parametric breast imaging that combines functional diffuse optical tomography (DOT), functional MRI, and MR Elastography for monitoring treatment responses of breast cancer; • Multi-modality imaging for early breast cancer diagnosis by combining DOT with structural 3D digital breast tomosynthesis (DBT); • Validated a new method of combining stand-alone 2D mammogram with functional DOT imaging in a 34-sample clinical trial. 2D-guided optical reconstruction reveals similar statistics to spatially co-registered 3D-guided reconstruction in differentiating tumor from other tissues; • Tissue segmentation algorithm development for anatomical structure prior generation to guide optical image reconstruction. >> Application Scientist, LighTouch Medical, Inc. October 2012 – October 2013 • Played leading role in planning and executing a military contract of investigating hematocrit, plasma protein and fluid shifting in a simulated internal hemorrhage scenario based on a cannulated rat model; • Developed and validated the first Raman based noninvasive continuous hematocrit monitoring prototype for clinical settings, and coordinated with nephrologists and nurse practitioners to collect clinical trials data for 9 volunteers at a local dialysis center; • Design of experiments, bulk-volume spectral data processing, analysis and interpretation. >> Research Assistant, Prof. Joseph Chaiken’s Group August 2007 – August 2012 • Engineered an improved prototype of in vivo non-invasive human blood glucose concentration detection Raman system which incorporated a novel PDPM human-machine interface; • Developed algorithm to calculate hematocrit using combined tissue elastic and inelastic emission; • Investigated the fluorescence and photo-dynamics of various constituents in epithelial tissue, ECM and blood cells, including hemoglobin, plasma, sugars, collagen, AGEs, etc.; • Applied Raman spectroscopy in characterizing chemical changes in glial scar formation and the effectiveness of chondroitinase treatment after traumatic spinal cord injury. >> Research Assistant, Prof. Kexin Xu’s Group September 2004 – February 2007 • Introduced a novel reference wavelength based analyte-specific spectral signal extraction algorithm according to the water displacement by solute molecules; • Applied chemometrics, such as PCA, PLS and NAS, in post-experiment data processing to effectively filter the background noise, thus improve the detection sensitivity; • Validated the feasibility of using NIR absorption and diffuse reflectance spectroscopy in non- invasive blood glucose monitoring in a rabbit animal model. >> Optical Engineer, Internship: SUNshine Optics Technology Co. Ltd. Tianjin Spring 2004 • Team worked in the optical route and mechanical structure design for an air quality monitoring system based on differential optical absorption spectroscopy; • Built a database of project-relevant ISO, EN, and GB standards for commercial manufacture.

TECHNICAL SKILLS Medical Imaging: DOT, MRI, MRE, X-ray mammogram, Ultrasound Spectroscopy: NIR, Raman, FT-IR, MALDI-TOF, LC/MS, UV-VIS, NMR Microscopy: Polarized light microscope, FT-IR microscope, Confocal Raman, AFM Material Analysis: HPLC, DLS, Rotational Rheometer, TGA, Refractometer Programming: MATLAB, R, Python, MySQL, SAS, VBA for Excel, C++ Data Processing: PLS, PCA, NAS, KNN, Regression Analysis, Statistical tests, Neural Networks Software Strength: OriginPro, LabVIEW, Unscrambler, GRAMS, ImageJ, Gaussian, OMNIC, JMP Animal Surgery: IACUC trained, Cannulated rat model, Rabbit model Technical Writings: IRB protocols, SOPs, Informed consent, Funding proposals

PUBLICATIONS 1. Bin Deng, Mats Lundqvist, Qianqian Fang, Stefan A. Carp, “Impact of errors in experimental parameters on reconstructed breast images using diffuse optical tomography”, Biomedical Optics Express, 9(3), 1130-50, 2018 2. Bernhard B. Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette Selb, Qianqian Fang, Amir Y. Sajjadi, Jayne Cormier, Richard M. Moore, Daniel B. Kopans, David A. Boas,

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Mansi A. Saksena, Stefan A. Carp, “Multi-Modal Breast Cancer Imaging using Co-Registered Dynamic Diffuse Optical Tomography and Digital Breast Tomosynthesis”, Journal of Biomedical Optics, 22(4), 046008, 2017 3. Amir Y. Sajjadi, Steven J. Isakoff, Bin Deng, Bhawana Singh, Christy M. Wanyo, Qianqian Fang, Michelle C. Specht, Lidia Schapira, Beverly Moy, Aditya Bardia, David A. Boas, Stefan A. Carp, “Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)”, Biomedical Optics Express, 8(2), 555-569, 2017 4. Paul Dent, Bin Deng, Jerry Goodisman, Charles M. Peterson, Sriram Narsipur, Joseph Chaiken, “Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish hemostasis for intravascular volume and composition”, Proc. of SPIE, Vol. 9887, 98871S, 2016 5. Bin Deng, Maxim Fradkin, Jean-Michel Rouet, Richard H. Moore, Daniel B. Kopans, David A. Boas, Mats Lundqvist, Qianqian Fang, “Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging”, Journal of Biomedical Optics, 20(8), 080502, 2015 6. Bin Deng, Dana H. Brooks, David A. Boas, Mats Lundqvist, Qianqian Fang, “Characterization of structural-prior guided optical tomography using realistic breast models derived from dual- energy x-ray mammography”, Biomedical Optics Express, 6(7), 2366-2379, 2015 7. Paul Dent, Bin Deng, Jerry Goodisman, Joseph Chaiken, “Coupled turbidity and spectroscopy problems: a simple algorithm for volumetric analysis of optically thin or dilute 2-phase systems”, Applied Spectroscopy, 69(3), 377-388, 2015 8. Bin Deng, Evan Kastner, Sriram Narsipur, Jerry Goodisman, Joseph Chaiken, “Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE”, Proc. of SPIE, Vol. 8935, 89351N-11, 2014 9. Bin Deng, Evan Kastner, Paul Dent, Jerry Goodisman, Joseph Chaiken, “Continuous non- invasive in vivo monitoring of intravascular plasma volume and hematocrit changes in response to blood removal and fluid replacement in a rat model”, Proc. of SPIE, Vol. 8935, 893526, 2014 10. Bin Deng, “The role of fluorescence and human factors in quantitative transdermal blood and tissue analysis using NIR Raman spectroscopy”, Syracuse University, Biomedical and Chemical Engineering – Dissertations, Paper 64, 2012 11. Bin Deng, Anabel Simental, Patrick Lutz, George Shaheen, Joseph Chaiken, “Singlet oxygen induced advanced glycation endproduct photobleaching of in vivo human fingertip autofluorescence”, Proc. of SPIE, Vol. 8219, 82190D, 2012 12. Joseph Chaiken, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, “Analyzing near infrared scattering from human skin to monitor changes in hematocrit”, Proc. of SPIE, Vol.8219, 821908, 2012 13. Joseph Chaiken, Bin Deng, Jerry Goodisman, G. Shaheen, R. J. Bussjager, “Analyzing near- infrared scattering from human skin to monitor changes in hematocrit”, Journal of Biomedical Optics, 16(9), 097005, 2011 14. Tarun Saxena, Bin Deng, Dennis Stelzner, Julie Hasenwinkel, Joseph Chaiken, “Raman spectroscopic investigation of spinal cord injury in a rat model”, Journal of Biomedical Optics,

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16(2), 027003, 2011 15. Tarun Saxena, Bin Deng, Kyle Hoellger, Eric Lewis-Clark, Julie M. Hasenwinkel, Joseph Chaiken, “Near infra-red Raman spectroscopic study of reactive gliosis and the glial scar in injured rat spinal cords”, Proc. of SPIE, Vol.7560, 75600I, 2010 16. Bin Deng, Colin Wright, Eric Lewis-Clark, George Shaheen, Roman Geier, Joseph Chaiken, “Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo”, Proc. of SPIE, Vol. 7560, 75600P, 2010 17. Joseph Chaiken, Bin Deng, Rebecca J. Bussjager, George Shaheen, David Rice, Dave Stehlik, John Fayos, “Instrument for near infrared emission spectroscopic probing of human fingertips in vivo”, Review of Scientific Instruments, 81, 034301, 2010 18. Joseph Chaiken, Jerry Goodisman, Bin Deng, Rebecca J. Bussjager, George Shaheen, “Simultaneous, noninvasive observation of elastic scattering, fluorescence and inelastic scattering as a monitor of blood flow and hematocrit in human fingertip capillary beds”, Journal of Biomedical Optics, 14(05), 050505, 1st Sep. 2009 19. Wenliang Chen, Bin Deng, Rong Liu, Xiaoyu Gu, Kexin Xu, “Methodology of effective glucose-specific signal extraction in complicated sample”, Proc. of SPIE, Vol. 6445, 64450L, 14th Feb. 2007 20. Xiaoyu Gu, Bin Deng, Lin An, Wenliang Chen, Kexin Xu, “The feasibility investigation of non- invasive blood glucose sensing based on near-infrared spectroscopy”, Proc. of SPIE, Vol. 6094, 60940J, 27th Feb. 2006 21. Rong Liu, Bin Deng, Wenliang Chen, Kexin Xu, “Next step of non-invasive glucose monitor by NIR technique from the well controlled measuring condition and results”, Optical and Quantum Electronics, 37, 1305-1317, 2005

CONFERENCE PRESENTATIONS 1. Bin Deng, Bernhard Zimmermann, Bhawana Singh, Qianqian Fang, Jayne Cormier, Richard Moore, Daniel Kopans, Mansi Saksena, David Boas, Stefan Carp, “Elucidating breast cancer pathophysiology using integrated dynamic DOT and digital breast tomosynthesis”, poster, the Second Britton Chance International Symposium on Metabolic Imaging and Spectroscopy, Philadelphia, PA, June 11-13, 2018 2. Bin Deng, Bernhard Zimmermann, Bhawana Singh, Qianqian Fang, Jayne Cormier, Richard Moore, Daniel Kopans, Mansi Saksena, David Boas, Stefan Carp, “Multimodal Breast Cancer Imaging Using Coregistered Dynamic DOT and Digital Breast Tomosynthesis”, oral presentation, OSA BIOMED, Hollywood, FL, April 3-6, 2018 3. Bin Deng, Mats Lundqvist, Qianqian Fang, Stefan Carp, “Tolerance of Reconstructed Diffuse Optical Tomographic Breast Images to Experimental Errors”, poster, OSA BIOMED, Hollywood, FL, April 3-6, 2018 4. Bin Deng, Bo Zhu, Amir Sajjadi, Stefan Carp, “Characterizing breast lesions using multimodal diffused optical tomography, magnetic resonance imaging and elastography”, oral presentation, SPIE Photonics West BiOS, San Francisco, CA, Jan 28 – Feb 2, 2017 5. Bin Deng, Dana H. Brooks, David A. Boas, Mats Lundqvist, Qianqian Fang, “Characterization of breast lesions using structural prior guided optical tomography on the realistic breast model – DigiBreast”, oral presentation, OSA BIOMED, Ft. Lauderdale, FL, April 25-28, 2016

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6. Bin Deng, Qianqian Fang, David A. Boas, Stefan Carp, “Impact of experimental parameter errors on reconstructed breast images using diffuse optical tomography”, oral presentation, OSA BIOMED, Ft. Lauderdale, FL, April 25-28, 2016 7. Dora C. Inácio, Bin Deng, Daniel B. Kopans, David A. Boas, Qianqian Fang, “Automatically finding tumors using structural-prior guided optical tomography”, oral presentation by colleague Qianqian Fang, OSA BIOMED, Ft. Lauderdale, FL, April 25-28, 2016 8. Bhawana Singh, Qianqian Fang, Bin Deng, Bernhard Zimmermann, David A. Boas, Jayne A. Cormier, Richard H. Moore, Daniel B. Kopans, Mansi A. Saksena, Stefan Carp, “Integrated near-infrared diffuse optical imaging and digital breast tomography for monitoring compression induced hemodynamics in breast cancer patients”, poster, OSA BIOMED, Ft. Lauderdale, FL, April 25-28, 2016 9. Bernhard Zimmermann, Bin Deng, Bhawana Singh, Qianqian Fang, David A. Boas, Stefan Carp, “Dynamic phantom measurements to validate a tomographic optical breast imaging system”, poster, OSA BIOMED, Ft. Lauderdale, FL, April 25-28, 2016 10. Paul Dent, Bin Deng, Jerry Goodisman, Charles M. Peterson, Sriram Narsipur, Joseph Chaiken, “Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish hemostasis for intravascular volume and composition”, oral presentation by colleague Joseph Chaiken, SPIE Biophotonics Europe, Brussels, Belgium, April 3-7, 2016 11. Bin Deng, Bernhard Zimmermann, Patricia Hibberd, Archana Patel, Qianqian Fang, “Non- contact mobile oximeter for rapid birth asphyxia and childhood pneumonia assessment”, invited poster, Saving Lives at Birth DevelopmentXChange, Washington DC, Jul 21-22, 2015 12. Bin Deng, Bernhard Zimmermann, Qianqian Fang, David A. Boas, Jayne A. Cormier, Daniel B. Kopans, Mansi A. Saksena, Stefan Carp, “Multi-modal dynamic breast compression imaging using diffuse optical tomography and x-ray digital breast tomosynthesis (DBT)”, oral presentation, SPIE Photonics West BiOS, San Francisco, CA, February 7-12, 2015 13. Qianqian Fang, Bin Deng, Dana H. Brooks, Stefan A. Carp, Richard H. Moore, Daniel B. Kopans, David A. Boas, “Clinical validation of combined x-ray and optical breast imaging with 215 lesion cases”, poster, RSNA, Chicago, IL, Nov 30 – Dec 05, 2014 14. Bin Deng, Evan Kastner, Sriram S. Narsipur, Jerry Goodisman, Joseph Chaiken, “New algorithm for continuous, noninvasive monitoring of hematocrit and plasma volume in humans: hemodialysis”, poster, OSA BIOMED, Miami, FL, April 26-30, 2014 15. Bin Deng, Maxim Fradkin, Daniel B. Kopans, David A. Boas, Magnus Aslund, Qianqian Fang, “Characterizing breast lesions using functional optical imaging guided by an independent X-ray mammogram”, poster, OSA BIOMED, Miami, FL, April 26-30, 2014 16. Qianqian Fang, Bin Deng, Stefan A. Carp, Richard H. Moore, Daniel B. Kopans, David A. Boas, “An 8-year clinical study of combing optical breast imaging with x-ray mammography for tumor diagnosis”, oral presentation by colleague Qianqian Fang, OSA BIOMED, Miami, FL, April 26- 30, 2014 17. Bin Deng, Evan Kastner, Sriram Narsipur, Jerry Goodisman, Joseph Chaiken, “Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE”, oral presentation by advisor Joseph Chaiken, SPIE Photonics West BiOS, San Francisco, CA, February 1-6, 2014 18. Bin Deng, Evan Kastner, Paul Dent, Jerry Goodisman, Joseph Chaiken, “Continuous

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noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes in response to blood removal and fluid replacement in a rat model”, poster, SPIE Photonics West BiOS, San Francisco, CA, February 1-6, 2014 19. Bin Deng, Anabel Simental, Patrick Lutz, George Shaheen, Joseph Chaiken, “Singlet oxygen induced advanced glycation endproduct photobleaching of in vivo human fingertip autofluorescence”, oral presentation, SPIE Photonics West BiOS, San Francisco, CA, January 21-26, 2012 20. Joseph Chaiken, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, “Analyzing near infrared scattering from human skin to monitor changes in hematocrit”, oral presentation by advisor Joseph Chaiken, SPIE Photonics West BiOS, San Francisco, CA, January 21-26, 2012 21. Bin Deng, Joseph Chaiken, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, “Glucose and other measurements”, invited oral presentation by advisor Joseph Chaiken, Imaging and Applied Optics: OSA Optics & Photonics Congress, Toronto, Canada, July 10-14, 2011 22. Bin Deng, Colin Wright, Eric Lewis-Clark, Roman Geier, George Shaheen, Joseph Chaiken, “Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo”, poster, ICORS 2010, Boston, MA, August 8-13, 2010 23. Tarun Saxena, Bin Deng, Kyle Hoellger, Eric Lewis-Clark, Dennis Stelzner, Julie Hasenwinkle, Joseph Chaiken, “Near Infrared Raman Spectroscopic Study of Reactive Gliosis and the Glial Scar in Injured Rat Spinal Cords”, poster, ICORS 2010, Boston, MA, August 8-13, 2010 24. Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, Joseph Chaiken, “Noninvasive, in-vivo, tissue modulated near infrared spectroscopy of fingertips: resonance Raman spectrum of human hemoglobin”, invited oral presentation by advisor Joseph Chaiken, ICORS 2010, Boston, MA, August 8-13, 2010 25. Bin Deng, Colin Wright, Eric Lewis-Clark, George Shaheen, Roman Geier, Joseph Chaiken, “Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo”, oral presentation, SPIE BiOS, San Francisco, CA, Jan 23-28, 2010 26. Tarun Saxena, Bin Deng, Kyle Hoellger, Eric Lewis-Clark, Julie M. Hasenwinkel, Joseph Chaiken, “Near infra-red Raman spectroscopic study of reactive gliosis and the glial scar in injured rat spinal cords”, oral presentation by colleague Tarun Saxena, SPIE BiOS, San Francisco, CA, Jan 23-28, 2010 27. Tarun Saxena, Bin Deng, Jeremy L. Gilbert, Dennis J. Stelzner, Joseph Chaiken, Julie M. Hasenwinkel, “Characterization of the glial scar using Raman spectroscopy, microindentation, and immunohistochemistry”, poster, Biomedical Engineering Society Annual Conference (BMES), Austin, TX, October 6-9, 2010 28. Tarun Saxena, Bin Deng, Jeremy L. Gilbert, Dennis J. Stelzner, Joseph Chaiken, Julie M. Hasenwinkel, “Molecular Characterization of the glial scar using Raman spectroscopy, microindentation, and immunohistochemistry”, poster, Society for Neuroscience Annual Conference, San Diego, CA, November 13-17, 2010

TEACHING EXPERIENCE >> Teaching Assistant Fall 2007 – Fall 2008 Courses: Engineering Analysis of Living System I & II Lab

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Lecturer: Prof. Gustav Engbretson & Andrew Darling • Main responsibilities: draft syllabus & lab instructions, equipment setup & debugging, give LabVIEW orientation, in-class trouble shooting & grading; • Scale of course: extracellular recording from earthworm nerve cord, sensory coding by a mechanoreceptor, vector electrocardiogram, action potential recording of frog gastrocnemius muscle, ion transport in toad bladder, whole animal plethysmography, and exercise physiology. >> Teaching Assistant Fall 2010 Courses: General Chemistry Lab Lecturer: Prof. Joseph Chaiken • Main responsibilities: conduct lab demonstration, supervise safety & grading; • Scale of course: paper chromatography, acid base titration, Redox reaction, estimating the caloric content of nuts, pH, heats of reaction, clock reaction.

STUDENT MENTORING • Steve Asiala Summer 2008 Project: Investigations into the degradation of hemoglobin Fluorescence • Ruben Guadalupe Spring 2009 Project: Analyzing the reaction of blood to direct exposure of NIR Raman • Colin Wright Spring 2010 Project: Investigation of near-infrared fluorescence and photobleaching of human volar side fingertips in vivo: antioxidants and melanin • Anabel Simental Summer 2011 Project: Origins of autofluorescence and photobleaching in human tissues • Dora Inácio Spring – Summer 2015 Project: Functional optical imaging assisted breast cancer screening and diagnosis • Kathleen Deabill Fall 2017 Project: Dynamic optical breast image data processing

HONORS & AWARDS • Prize of Excellence, Graduate Scholarship, Tianjin University 2005 – 2007 • WISE-FPP Fellowship, Syracuse University 2009 – 2011 • Travel Award, Department of Chemistry, Syracuse University 2010 & 2012 • Poster of Merit Award at MGH ORCD Research Fellow Poster Celebration 2014 • Review Committee for MGH ORCD Poster Celebration 2015 • Travel Award, the Second Britton Chance International Symposium 2018 • Best Poster Award, the Second Britton Chance International Symposium 2018

PROFESSIONAL AFFILIATIONS • Member, American Association for the Advancement of Science (AAAS) 2007 – present • Member, International Society for Optical Engineering (SPIE) 2009 – present • Women in Science and Engineering – Future Professoriate Program (WISE-FPP) 2009 – 2011 • Vice President, Syracuse University Student Chapter of Society for Biomaterials 2010 – 2012

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• Committee member of Mass General Postdoc Association (MGPA) 2013 – 2015 • Technical Program Committee, the International Conference on Biomedical Engineering and Biotechnology (ICBEB) 2013 – present • Member, Optical Society of America (OSA) 2013 – present • Reviewer for peer-reviewed journals Optics Express, Optics Letter, Applied Optics, Biomedical Optics Express, Journal of Biomedical Optics, etc.

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