BIN DENG Curriculum Vitae MGH/HST Athinoula A. Martinos Center for Biomedical Imaging 149 13th St., Suite 2280-B, Charlestown, MA, 02129 [email protected] (617) 726-9338 EDUCATION Syracuse University, Syracuse, NY Doctor of Philosophy, Bioengineering August 2012 Thesis: The role of fluorescence and human factors in quantitative transdermal blood and tissue analysis using NIR Raman spectroscopy Advisor: Prof. Joseph Chaiken Tianjin University, College of Precision Instrument & Optoelectronics Engineering, China Master of Science, Measuring and Testing Technology and Instrument March 2007 Thesis: Theoretical and experimental study on effective extraction of glucose specific signal in NIR spectroscopy Advisor: Prof. Kexin Xu Bachelor of Science, Biomedical Engineering July 2004 Senior Thesis: Mechanical design and application of DOAS (differential optical absorption spectroscopy) system for atmospheric quality monitoring Advisor: Prof. Yan Wang PROFESSIONAL POSITIONS 10/2012 – 10/2013 Application Scientist LighTouch Medical, Inc. 10/2013 – 03/2018 Research Fellow Massachusetts General Hospital Martinos Center for Biomedical Imaging 03/2018 – present Instructor Harvard Medical School Research Staff MGH – Martinos Center RESEARCH EXPERIENCE >> Research Fellow, MGH Martinos Center for Biomedical Imaging October 2013 – March 2018 • Multi-parametric breast imaging that combines functional diffuse optical tomography (DOT), functional MRI, and MR Elastography for monitoring treatment responses of breast cancer; • Multi-modality imaging for early breast cancer diagnosis by combining DOT with structural 3D digital breast tomosynthesis (DBT); • Validated a new method of combining stand-alone 2D mammogram with functional DOT imaging in a 34-sample clinical trial. 2D-guided optical reconstruction reveals similar statistics to spatially co-registered 3D-guided reconstruction in differentiating tumor from other tissues; • Tissue segmentation algorithm development for anatomical structure prior generation to guide optical image reconstruction. >> Application Scientist, LighTouch Medical, Inc. October 2012 – October 2013 • Played leading role in planning and executing a military contract of investigating hematocrit, plasma protein and fluid shifting in a simulated internal hemorrhage scenario based on a cannulated rat model; • Developed and validated the first Raman based noninvasive continuous hematocrit monitoring prototype for clinical settings, and coordinated with nephrologists and nurse practitioners to collect clinical trials data for 9 volunteers at a local dialysis center; • Design of experiments, bulk-volume spectral data processing, analysis and interpretation. >> Research Assistant, Prof. Joseph Chaiken’s Group August 2007 – August 2012 • Engineered an improved prototype of in vivo non-invasive human blood glucose concentration detection Raman system which incorporated a novel PDPM human-machine interface; • Developed algorithm to calculate hematocrit using combined tissue elastic and inelastic emission; • Investigated the fluorescence and photo-dynamics of various constituents in epithelial tissue, ECM and blood cells, including hemoglobin, plasma, sugars, collagen, AGEs, etc.; • Applied Raman spectroscopy in characterizing chemical changes in glial scar formation and the effectiveness of chondroitinase treatment after traumatic spinal cord injury. >> Research Assistant, Prof. Kexin Xu’s Group September 2004 – February 2007 • Introduced a novel reference wavelength based analyte-specific spectral signal extraction algorithm according to the water displacement by solute molecules; • Applied chemometrics, such as PCA, PLS and NAS, in post-experiment data processing to effectively filter the background noise, thus improve the detection sensitivity; • Validated the feasibility of using NIR absorption and diffuse reflectance spectroscopy in non- invasive blood glucose monitoring in a rabbit animal model. >> Optical Engineer, Internship: SUNshine Optics Technology Co. Ltd. Tianjin Spring 2004 • Team worked in the optical route and mechanical structure design for an air quality monitoring system based on differential optical absorption spectroscopy; • Built a database of project-relevant ISO, EN, and GB standards for commercial manufacture. TECHNICAL SKILLS Medical Imaging: DOT, MRI, MRE, X-ray mammogram, Ultrasound Spectroscopy: NIR, Raman, FT-IR, MALDI-TOF, LC/MS, UV-VIS, NMR Microscopy: Polarized light microscope, FT-IR microscope, Confocal Raman, AFM Material Analysis: HPLC, DLS, Rotational Rheometer, TGA, Refractometer Programming: MATLAB, R, Python, MySQL, SAS, VBA for Excel, C++ Data Processing: PLS, PCA, NAS, KNN, Regression Analysis, Statistical tests, Neural Networks Software Strength: OriginPro, LabVIEW, Unscrambler, GRAMS, ImageJ, Gaussian, OMNIC, JMP Animal Surgery: IACUC trained, Cannulated rat model, Rabbit model Technical Writings: IRB protocols, SOPs, Informed consent, Funding proposals PUBLICATIONS 1. Bin Deng, Mats Lundqvist, Qianqian Fang, Stefan A. Carp, “Impact of errors in experimental parameters on reconstructed breast images using diffuse optical tomography”, Biomedical Optics Express, 9(3), 1130-50, 2018 2. Bernhard B. Zimmermann, Bin Deng, Bhawana Singh, Mark Martino, Juliette Selb, Qianqian Fang, Amir Y. Sajjadi, Jayne Cormier, Richard M. Moore, Daniel B. Kopans, David A. Boas, BIN DENG Page 2 Mansi A. Saksena, Stefan A. Carp, “Multi-Modal Breast Cancer Imaging using Co-Registered Dynamic Diffuse Optical Tomography and Digital Breast Tomosynthesis”, Journal of Biomedical Optics, 22(4), 046008, 2017 3. Amir Y. Sajjadi, Steven J. Isakoff, Bin Deng, Bhawana Singh, Christy M. Wanyo, Qianqian Fang, Michelle C. Specht, Lidia Schapira, Beverly Moy, Aditya Bardia, David A. Boas, Stefan A. Carp, “Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)”, Biomedical Optics Express, 8(2), 555-569, 2017 4. Paul Dent, Bin Deng, Jerry Goodisman, Charles M. Peterson, Sriram Narsipur, Joseph Chaiken, “Noninvasive in vivo plasma volume and hematocrit in humans: observing long-term baseline behavior to establish hemostasis for intravascular volume and composition”, Proc. of SPIE, Vol. 9887, 98871S, 2016 5. Bin Deng, Maxim Fradkin, Jean-Michel Rouet, Richard H. Moore, Daniel B. Kopans, David A. Boas, Mats Lundqvist, Qianqian Fang, “Characterizing breast lesions through robust multimodal data fusion using independent diffuse optical and x-ray breast imaging”, Journal of Biomedical Optics, 20(8), 080502, 2015 6. Bin Deng, Dana H. Brooks, David A. Boas, Mats Lundqvist, Qianqian Fang, “Characterization of structural-prior guided optical tomography using realistic breast models derived from dual- energy x-ray mammography”, Biomedical Optics Express, 6(7), 2366-2379, 2015 7. Paul Dent, Bin Deng, Jerry Goodisman, Joseph Chaiken, “Coupled turbidity and spectroscopy problems: a simple algorithm for volumetric analysis of optically thin or dilute 2-phase systems”, Applied Spectroscopy, 69(3), 377-388, 2015 8. Bin Deng, Evan Kastner, Sriram Narsipur, Jerry Goodisman, Joseph Chaiken, “Continuous noninvasive in vivo monitoring of intravascular plasma volume and hematocrit changes during hemodialysis in humans: direct comparison with the CRIT-LINE”, Proc. of SPIE, Vol. 8935, 89351N-11, 2014 9. Bin Deng, Evan Kastner, Paul Dent, Jerry Goodisman, Joseph Chaiken, “Continuous non- invasive in vivo monitoring of intravascular plasma volume and hematocrit changes in response to blood removal and fluid replacement in a rat model”, Proc. of SPIE, Vol. 8935, 893526, 2014 10. Bin Deng, “The role of fluorescence and human factors in quantitative transdermal blood and tissue analysis using NIR Raman spectroscopy”, Syracuse University, Biomedical and Chemical Engineering – Dissertations, Paper 64, 2012 11. Bin Deng, Anabel Simental, Patrick Lutz, George Shaheen, Joseph Chaiken, “Singlet oxygen induced advanced glycation endproduct photobleaching of in vivo human fingertip autofluorescence”, Proc. of SPIE, Vol. 8219, 82190D, 2012 12. Joseph Chaiken, Bin Deng, Jerry Goodisman, George Shaheen, Rebecca J. Bussjager, “Analyzing near infrared scattering from human skin to monitor changes in hematocrit”, Proc. of SPIE, Vol.8219, 821908, 2012 13. Joseph Chaiken, Bin Deng, Jerry Goodisman, G. Shaheen, R. J. Bussjager, “Analyzing near- infrared scattering from human skin to monitor changes in hematocrit”, Journal of Biomedical Optics, 16(9), 097005, 2011 14. Tarun Saxena, Bin Deng, Dennis Stelzner, Julie Hasenwinkel, Joseph Chaiken, “Raman spectroscopic investigation of spinal cord injury in a rat model”, Journal of Biomedical Optics, BIN DENG Page 3 16(2), 027003, 2011 15. Tarun Saxena, Bin Deng, Kyle Hoellger, Eric Lewis-Clark, Julie M. Hasenwinkel, Joseph Chaiken, “Near infra-red Raman spectroscopic study of reactive gliosis and the glial scar in injured rat spinal cords”, Proc. of SPIE, Vol.7560, 75600I, 2010 16. Bin Deng, Colin Wright, Eric Lewis-Clark, George Shaheen, Roman Geier, Joseph Chaiken, “Direct noninvasive observation of near infrared photobleaching of autofluorescence in human volar side fingertips in vivo”, Proc. of SPIE, Vol. 7560, 75600P, 2010 17. Joseph Chaiken, Bin Deng, Rebecca J. Bussjager, George Shaheen, David Rice, Dave Stehlik, John Fayos, “Instrument for near infrared emission spectroscopic probing of human fingertips in vivo”, Review of Scientific Instruments, 81, 034301, 2010 18. Joseph Chaiken, Jerry Goodisman, Bin