CSJ 11(2): December, 2020 ISSN: 2276 – 707X Namadina et al. ChemSearch Journal 11(2): 73 – 81, December, 2020 Publication of Chemical Society of Nigeria, Kano Chapter Received: 15/11/2020 Accepted: 02/12/2020 http://www.ajol.info/index.php/csj Phytochemical, Antifungal and Acute Toxicity Studies of Mitracarpus scaber Zucc. Whole Plant Extracts 1*Namadina, M. M., 2Mukhtar, A.U., 2Musa, F. M., 3Sani, M. H., 4Haruna, S., 1Nuhu, Y. and 5Umar, A. M. 1Department of Plant Biology, Bayero University, Kano, Nigeria. 2Department of Microbiology, Kaduna State University 3Department of Plant sciences and Biotechnology, Nasarawa State University, Keffi 4Department of Forestry, Audu Bako Collage of Agriculture, Dambatta 5Department of Remedial and General Studies, Audu Bako Collage of Agriculture, Dambatta *Correspondence Email:
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[email protected] ABSTRACT Mitracarpus scaber have been reported in the treatment of various ailments such as ulcer, cancer, skin diseases etc. It is therefore important to investigate these plant parts to ascertain their therapeutic potentials. The Mitracarpus scaber whole plant was extracted with water and methanol, screened for their phytochemical properties and antifungal effects. The plant samples were also investigated for alkaloid, flavonoids, saponins, tannins and phenolic contents using quantitative techniques. The antifungal activities of the plant samples were tested against Candida albicans, Trichophyton mentagrophytes, Microsporum auduounii and Aspergillus flavus. The Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) of the extracts were also determined. Flavonoid, steroid, triterpenes, tannins, carbohydrate, glycoside, phenols were detected in both extracts while anthraquinones was absent. Alkaloid was detected in the aqueous extract but absent in methanol extract.