SUBJECT INDEX 1961 ABS -ADR

ABSORPTION (1) morphine addiction 8535 concentration effects 8516 morphine withdrawal 8535 local anesthetics 8516 plasma l7-OHCS levels 8535 mucous membrane applications 8516 urinary l7-OHCS excretion 8535 relative toxicities 8516 ADRENAL GLANDS (11) ACENOCOUNAROL (sIN’rRoM) (2) adrenal vein effluents 8534 oxygen consumption 8533 anesthetized rats 8551 rat liver slices 8533 ascorbic acid content 8551 ACETIC ACID (3) catecholamine output 8534 concentration 8547 histamine-induced stress 8551 E. coli 8547 medullary hormones 8534 inhibitor activity 8547 morphine inhibitor activity 8551 ionized acid 8547 nalorphine-morphine oxidative metabolism 8547 antagonism 8551 unionized acid 8547 selective secretion 8534 ACETYLSALICYLIC ACID (4) ADRENAL MEDULLA (12) laboratory animals 8532 catecholamine release 8506 metabolism 8532 triethyltin 8506 oral toxicity 8532 ADRENALECTONY (13) ACETYLSTROPHANTHIDIN (5) amphetamine toxicity 8557 DCI influence 8558 blood pressure 8526 heart arrhythmias 8558 8527 isolated perfused heart 8558 ganglionic blockade 8509 ACIDOSIS, METABOLIC (6) McN-A-343 response 8526 aminophylline response 8553 neostigmine pressor response 8509 electrolyte excretion 8553 senecioylcholine response 8527 unanesthetized dog 8553 stressed animals 8557 ACTH (7) sympathectomy 8509 adrenal ascorbic acid 8551 tissue catecholamine content 8506 anesthetized rats 8551 beta-TM-lO 8509 blood eosinophiles 8535 triethyltin 8506 central nervous system 8551 A.DRENERGIC AGENTS (14) histamine-induced secretion 8551 adrenergic blocking agents 8510 human subjects 8535 blood flow responses 8510 morphine addiction 8535 catecholamines 8554 morphine inhibitor activity 8551 curarized animals 8554 nalorphine-morphine EEC 8554 antagonism 8551 epinephrine 8510 plasma 17-OHCS levels 8535 intra-arterial injections 8510 stress response 8551 levarterenol 8510 ADENOSINE TRIPHOSPHATE (8) skeletal muscle bed 8510 contractile tension 8525 ADRENERGIC BLOCKADE (15) glycerol-extracted fibers 8525 blood pressure 8527 heart muscle 8525 dibenamine 8509 “relaxing factor” 8525 ganglionic blockade 8509 ADENYL COMPOUNDS (9) neostigmine pressor response 8509 “crude burn” material 8520 phenoxybenzamine 8509 skin burns 8520 phentolamine 8509 ADRENAL CORTEX (10) 8527 functional activity 8535 piperoxan 8509 human subjects 8535 senecioylcholine response 8527

S-I SUBJECT INDEX ADR-AMP VOL. 132

ADRENERCIC BLOCKING AGENTS (16) Gamma-AMINOBUTYRIC ACID (20) action duration 8510 autonomic ganglia 8508 adrenergic agents 8510 concentration effect 8508 albino rabbits 8555 depressant activity 8508 amphetamine stimulation hexamethonium comparison 8508 pattern 8555 intra-arterial injection 8508 amphetamine toxicity 8557 synaptic transmission 8508 azapetine 8510 tachyphylaxis 8508 8554 8555 AMINOPHYLLINE (21) blood flow responses 8510 diuretic effect 8553 catecholamine stimulant hydrochlorothiazi de response 8554 pretreatment 8553 chlorpromazine 8554 kidney function 8553 8555 mercaptomerin pretreatment 8553 conductance 8510 metabolic acidosis 8553 cortical electrogenesis 8554 metabolic alkalosis 8553 8555 renal electrolyte excretion 8553 curarized animals 8554 specific refractoriness 8553 dibenamine 8555 unanesthetized dogs 8553 dibozane 8510 AMPHETAMINE (22) dihydroergotamine 8554 adaptation influence 8518 8555 adrenalectomy 8557 EEC patterns 8554 adrenergic blocking agents 8555 8555 aggregated mice 8518 hypotensive potency 8510 albino rabbits 8555 intra-arterial injection 8510 body temperature 8518 isoproterenol stimulant chlorpromazine pretreatment 8557 action 8554 cortical electrogenesis 8555

pentobarbital pretreatment 8555 EEC stimulation pattern #{149} 8555 phenoxybenzamine 8510 isolated mice 8518 8554 8555 lethal toxicity 8518 phenoxybenzamine pretreatment 8557 8557 phentolamine 8554 pentobarbital pretreatment 8555 8555 pentylenetetrazol seizure skeletal muscle bed 8510 threshold 8518 stressed animals 8557 phenoxybenzamine pretreatment 8557 ADRENOCORTICAL STEROIDS (17) stressed animals 8557 adrenalectomized rats 8536 toxicity mechanism 8518 anti-inflammatory action 8536 d-AMPHETAMINE (23) body weight changes 8536 albino mice 8517 electrolyte excretion 8536 atropine-induced augmentation 8517 erythrocyte Fe59 harmaline pretreatment 8539 incorporation 8536 imipratnine pretreatment 8529 thymolytic activity 8536 iproniazid pretreatment 8529 ALKALOSIS, METABOLIC (18) 8539 aminophylline response 8553 metabolic destruction in vivo 8529 electrolyte excretion 8553 motor activity 8517 unanesthetized dogs 8553 pyridindole II pretreatment 8539 AMINO ACIDS-C14 (19) shock avoidance responses 8517 E. coli cell fractions 8505 spider sensitivity 8529 protein distribution 8505 spontaneous activity 8539 RNA incorporation 8505 stimulatory response 8539 web-building behavior 8529

S-2 SUBJECT INDEX 1961 AMA-ANT

ANALGESIA (24) lethal toxicity 8512 albino mice 8556 neuromuscular block 8512 antiparkinsonian agents 8556 organophosphorus compounds 8512 tremorine induced 8556 oxime-atropine treatment 8512 ANALGESICS (25) ANTICHOLINESTERASES (32) EEC 8515 atropine blocking action 8509 evoked brain potentials 8515 ganglionic blockade 8509 morphine 8515 neostigmine pressor response 8509 8540 neuromuscular transmission 8514 nal orphine 8515 physostigmine comparison 8509 phenazocine 8540 quaternary ammonium compounds 8514 potency ratio 8540 twitch potentiating potencies 8514 thermal radiation test 8540 ANTICOAGULANTS (33) tooth pulp stimulation 8515 oxygen consumption 8533 ANESTHETICS, LOCAL (26) rat liver slices 8533 action duration 8516 ANTICONVULSANTS (34) anesthetic efficiencies 8516 albino mice 8556 concentration effects 8516 chlorphenoxamine 8556 intranasal application 8516 maximal PTZ seizures 8556 intratracheal application 8516 MES test 8556 intravenous administration 8516 nicotine convulsions 8556 intravesical application 8516 PTZ threshold test 8556 rabbit nasal mucosa 8516 strychnine lethality 8556 rabbit sneeze reflex 8516 ANTIEMETICS (35) relative safety 8516 comparative potency 8540 toxici ties 8516 drug-induced emesis 8540 ANGIOTONIN (27) morphine 8540 arterial strips 8507 phenazoc me 8540 mecamylamine potentiation 8507 ANTIHISTAMINES (36) TEA potentiation 8507 heparin hydrolysates 8513 ANOXIA (28) pyri lamine 8513 cat papillary muscles 8524 smooth muscle contraction 8513 ouabain response 8524 ANTI-INFLAMMATORY AGENTS (37) ANTIARRHYTIINIA AGENTS (29) adrenalectomized rats 8536 acetylstrophanthidin adrenocortical steroids 8536 ventricular tachycardia 8559 asbestos granuloma test 8536 dichloroi soproterenol 8558 20-cobalto-delta-l- isolated rabbit hearts 8559 hydrocorti sone 8536 ouabain-induced arrhythmia 8558 cobaltous chloride procaine ethylchloride 8559 hexahyd rate 8536 procaine ethylchloride cation 8559 granuloma pouch exudate 8536 procaine hydrochloride 8559 hydrocort i sone 8536 procaine ionization 8559 predni so lone 8536 related dichloro compounds 8558 ANTIPARKINSONIAN AGENTS (38) ANTIBIOTICS (30) adult dogs 8556 cell suspensions 8505 albino mice 8556 chloramphenicol 8505 anticholinergic effects 8556 E. coli 8505 canine chorea 8556 ANTICHOLINESTERASE INTOXICATION, chlorphenoxamine 8556 EXPERIMENTAL (31) comparative activities 8556 albino rabbits 8512 flexor spasm syndrome 8556

S-3 SUBJECT INDEX ANT -BLO VOL. 132

keithon 8556 BARBITAL (45) nicotine convulsions 8556 barbital pretreatment 8531 tremorine analgesia 8556 chlorcyclizine pretreatment 8531 tremorine tremors 8556 metabolism rate 8546 ANTITREMOR AGENTS (39) nikethamide treated animals 8546 albino mice 8556 orphenadrine pretreatment 8531 chlorphenoxamine 8556 phenobarbital pretreatment 8531 keithon 8556 rat liver microsomes 8546 tremorine tremors 8556 sleeping time 8531 ASCORBIC ACID (40) 8546 adrenal gland content 8551 BARBITURATES (46) anesthetized rats 8551 adult rats 8546 histamine response 8551 chlorcyclizine pretreatment 8531 morphine inhibitor activity 8551 metabolism 8531 nalorphine -morphine 8546 antagonism 8551 nikethamide pretreatment 8546 ATROPINE (41) sleeping time 8546 amphetamine reactions 8517 weanling rats 8546 anticholinesterase poisoning 8512 BARIUM (47) anticonvulsant activity 8556 arterial strips 8507 antidotal effect 8512 mecamylamine potentiation 8507 antitremor activity 8556 TEA potentiation 8507 augmentation effect 8517 BENZTROPINE (48) autonomic ganglia 8526 anticonvulsant activity 8556 avoidance responding 8517 antitremor activity 8556 blocking effect 8509 tremorine analgesia 8556 8526 BIOASSAY (49) hexamethonium pretreatment 8509 active substance release 8520 McN-A-343 stimulant activity 8526 discrimination index 8520 motor activity 8517 skin burns 8520 neostigmine pressor response 8509 smooth muscle preparations 8520 oxime adjuvant action 8512 subcutaneous pocket tremorine analgesia 8556 diffusates 8520 AUTONOMIC GANGLIA (42) BISHYDROXYCOUNARIN (DICuMAROL) gamma-aminobutyric acid 8508 Cl4-labeled (50)8533 atropine blocking action 8526 liver cell fractions 8533 decerebrate cats 8508 oxygen consumption 8533 differential sensitivity 8508 radioactivity distribution 8533 McN-A-343 stimulation 8526 rat liver slices 8533 synaptic transmission 8508 BLOOD EOSINOPHILES (51) AUTONOMIC NERVOUS SYSTEM, abstinence intensity 8535 CENTRAL (43) ACTH response 8535 chlorpromazine 8528 human subjects 8535 comparative effects 8528 morphine addiction 8535 parasympathetic activity 8528 morphine withdrawal 8535 re serpine 8528 BLOOD FLOW (52) tetrabenazine 8528 adrenergic agents 8510 AZAPETINE (44) adrenergic blocking agents 8510 adrenergic blocking agent 8510 anesthetized dogs 8510 blood flow responses 8510 atropine antagonism 8526 constant pressure perfusion 8510

S -4 SUBJECT INDEX 1961 BLIO -BRA

femoral vascular bed 8510 lobeline 8511 8526 McN-A-343 responses 8526 intra-arterial injections 8510 mecamylamine pretreatment 8526 8526 morphine 8515 McN-A-343 -induced 8540 vasodilatation 8526 nalorphine 8515 sympathetic nerve stimulation 8510 neostigmine pressor response 8509 BLOOD PRESSURE (53) ouabain arrhythmia 8558 acetylcholine 8527 phenazocine 8540 ACh depressor response 8526 phentolamine pretreatment 8527 adrenal medullary secretion 8534 phenyldiguanide 8511 adrenalectomy 8526 pressor response 8507 8527 8526 8534 adrenergic agents 8510 reflex depressor response 8511 adrenergic blocking agents 8510 reserpine pretreatment 8526 8554 senecioylcholine pressor anesthetized cats 8511 effect 8527 8527 serotonin 8511 anesthetized dogs 8521 spinal cord section 8526 8526 8527 8534 8558 splanchnic nerve stimulation 8534 atropine 8509 stabilization experiments 8558 atropine blocking action 8526 sympathectomy 8526 atropine pretreatment 8527 tetraethylammonium blood flow responses 8510 pretreatment 8526 bretylium blocking action 8526 tooth pulp stimulation 8515 catecholamines 8554 vagal stimulation 8509 C-O pressor response 8509 vagotomized pithed cats 8507 8526 vascular shock 8521 curarized animals 8554 vasoeffector cells 8507 DCI antiarrhythmia activity 8558 vasoexcitatory agents 8507 DCI depressor effect 8558 veratridine 8511 depressor effect 8521 BODY TEMPERATURE (54) 8540 aggregated mice 8518 depressor response 8526 amphetamine toxicity 8518 dialyzed placental extract 8521 BORAX (55) dibozane pretreatment 8526 acute toxicity 8560 dichloroi soproterenol 8554 borax:D-glucose molar ratios 8560 DMPP comparison 8526 D-glucose inhibition 8560 dose-latent period 8511 D-glucose potentiation 8560 dose -response 8511 mice mortality data 8560 ECG 8521 simultaneous administration 8560 EEC patterns 8554 temperature effect 8560 epinephrine 8527 BRADYKININ (56) epinephrine pressor response 8526 “crude burn” material 8520 epinephrine sensitivity 8507 skin burns 8520 evoked brain potentials 8515 subcutaneous pocket ganglionic blocking agents 8507 diffusates 8520 hexamethonium pretreatment 8509 BRAIN (57) 8526 8527 adrenal ectomy 8506 intra-arterial injections 8510 adrenergic blocking agents 8554 i soproterenol 8554 adrenergic receptors 8554

S -5 SUBJECT INDEX BRA-CAR VOL. 132

albino rats 8542 CALCIUM (59) brain stem responses 8515 cat papillary muscles 8524 catecholamine content 8542 concentration effects 8524 catecholamine metabolism 8543 contractile tension 8525 catecholamine release 8506 glycerol-extracted fibers 8525 catecholamines 8554 heart muscle 8525 catechol -0-methyltransferase 8543 ouabain action 8524 catron effect 8543 “relaxing factor” 8525 chiorpromazine effect 8528 CAPILLARIES (60) COIif activity 8542 fetal placental extract 8521 cortical electrogenesis 8554 histamine comparison 8521 cortical potentials 8515 intradermal injection 8521 cortical recruitment 8515 permeability 8521 curarized animals 8554 CARAMIPHEN (61) dichloroi soproterenol 8554 anticonvulsant activity 8556 differential activity 8528 antitremor activity 8556 dopa effect 8543 tremorine analgesia 8556 EEC 8515 CARBOXYTOLBUTA.MIDE (62) EEC patterns 8554 excretion kinetics 8519 evoked potentials 8515 human subjects 8519 5-NT content 8506 intravenous injection 8519 intracellular catecholamine oxidation product 8519 distribution 8543 tolbutamide administration 8519 iproniazid pretreatment 8542 urine volume 8519 i soproterenol 8554 CARDIAC GLYCOSIDES (63)

MAO activity 8542 . cat papillary muscles 8524 medullary reticular formation 8515 cation influence 8524 monoamine oxidase 8543 inotropic stage 8524 morphine 8515 intracellular cation nalorphine 8515 concent rations 8524 neuronal systems 8528 metabolic effects 8524 norepinephrine content 8506 toxic stage 8524 norepinephrine metabolism 8542 CARDIOVASCULAR SYSTEM (64) particulate fraction 8543 adrenergic blockade 8509 primary afferent pathways 8515 anesthetized rats 8539 pyrogallol effect 8543 atropine 8509 pyrogallol pretreatment 8542 blood flow 8526 reserpine effect 8528 blood pressure 8526 8543 8539 sciatic nerve stimulation 8515 ECG 8539 secondary afferent pathways 8515 epinephrine response 8539 soluble fraction 8543 ganglionic blockade 8509 somatosensory cortex 8515 heart contraction force 8526 thalamus 8515 heart rate 8526 tissue catecholamine isolated frog heart 8539 concentration 8543 lobeline responses 8511 tooth pulp stimulation 8515 McN-A-343 8526 triethyltin effect 8506 neostigmine pressor response 8509 BURNS (58) norepinephrine response 8539 active substance release 8520 phenyldiguanide comparison 8511 rat skin 8520 pyridindole II 8539 tissue damage 8520 reflex bradycardia 8511

S -6 SUBJECT INDEX 1961 CAR-Cl!]

reflex hypotension 8511 anesthetized rats 855 serotonin comparison 8511 atropine-induced augmentation 85U sympathetic ganglionic avoidance behavior 85U Stimulant 8526 depressant effects 85O( vagotomy 8511 depressants 853 veratridine comparison 8511 duration effects 85U CATECHOLAMINES (65) evoked brain potentials 85l adrenal medulla 8534 excitability 8511 adrenergic blocking agents 8554 FFA stress response 852 blood pressure 8554 histamine-induced stress 855: carotid sinus denervation 8554 hypnotics 853 catron 8543 hypothalamic-adrenal combined drug effects 8543 discharge 850 COMT inhibitor 8542 maximum response values 851 concentration 8543 methyl atropine 851 curarized animals 8554 morphine 85L DCI pretreatment 8554 morphine-inhibited ACTH dopa 8543 secretion 855 EEC stimulant action 8554 motor activity 851 endogenous accumulation 8542 nalorphine 85L epinephrine -norepinephrine nalorphine -morphine ratios 8534 antagonism 855 inactivation mechanisms 8530 operant behavior 85Y intracellular distribution 8543 pentylenetetrazol seizure i soproterenol 8554 threshold 8511 MAO inhibitors 8542 pyridindole II influence 853 metabolic pathways 8542 spontaneous activity 853 o-methylation 8530 stimulants 853 norepinephrine-H3 injection 8530 tranquilizing agents 852 pyrogallol 8543 triethyltin 850( rabbit brain fractions 8543 CHLORAMPHENICOL-H3 (68) rat tissue 8542 E. coli cell fractions 850 reserpine 8543 intracellular fate 850 reserpine pretreatment 8554 radioactivity distribution 85O selective secretion 8534 RNA incorporation 850 spinal cord section 8554 selective localization 85O splanchnic nerve stimulation 8534 CHLORCYCLIZINE (69) tissue binding 8530 barbiturate metabolism 853 tissue content 8506 stimulatory effect 853] triethyltin pretreatment 8506 TPNH metabolism 853] CATECHOLAMINES, ENDOGENOUS (66) 4 - (-CHLOROPHENYLCARBAMOYLOXY) - iproniazid pretreatment 8523 2 -BUTYNYLTRIMETHYLANMONIUM isolated guinea-pig atria 8523 (MCN-A-343) (70) PIH pretreatment 8523 pharmacologic properties 852 spontaneous depletion 8523 sympathetic ganglionic CENTRAL NERVOUS SYSTEM (67) stimulant 852( adrenal ascorbic acid 8551 CHLORPHENOXAMINE (71) afferent somatic pathways 8515 anticonvulsant effects 855( aggregated mice 8518 antitremor effects 855( amphetamine responses 8517 hexobarbital sleeping time 855( amphetamine toxicity 8518 tremorine analgesia 855(

s-: SUBJECT INDEX CHL-DIC VOL. 132

CHLORPROMAZINE (72) CONVULSIONS (79) albino rats 8522 antiparkinsonian agents 8556 amphetamine toxicity 8557 nicotine induced 8556 central autonomic activity 8528 CUMACHLOR (80) central sympathetic oxygen consumption 8533 depression 8528 rat liver slices 8533 denervated pupils 8528 CYCRIMINE (81) electric-shock stress 8522 anticonvulsant activity 8556 light reflex sensitivity 8528 antitremor activity 8556 miotic action 8528 tremorine analgesia 8556 plasma FFA 8522 stressed animals 8557 tranquilizing action 8522 DEMETHYLATION (82) CHOLINESTERASES (73) dimethylnirvanol metabolism 8545 drug-induced facilitation 8514 female dogs 8545 human erythrocytes 8514 DIABETES INSIPIDUS (83) inhibition factor 8514 dimercaprol effect 8552 neuromuscular transmission 8514 free water clearance 8552 quaternary ammonium ions 8514 maximal water diuresis 8552 twitch potentiation 8514 mercurial diuresis 8552 COBALT CHLORIDE ILEXAHYDRATE (74) supraopt ico -hypophyseal adrenalectomized rats 8536 section 8552 adrenocortical activity 8536 unanesthetized dogs 8552 anti-inflammatory effect 8536 water load 8552

erythrocyte Fe59 DIAZADAMANTANE (1 757 I . S . ) (84) incorporation 8536 dorsal root stimulation 8537 2O-COBALTO-Delta-l -HYDRO- pentylenetetrazol comparison 8537 CORTISONE (75) Renshaw cell activity 8537 adrenocortical steroids 8536 spinal inhibition blockade 8537 anti-inflammatory activity 8536 spinal reflex augmentation 8537 diuretic effect 8536 strychnine comparison 8537 electrolyte excretion 8536 DIBOZANE (85) erythrocyte Fe59 adrenergic blockingagents 8510 incorporation 8536 blood flow responses 8510 metabolic effect 8536 epinephrirte constrictor natriuretic effect 8536 action 8510 thymus involution 8536 levarterenol constrictor COBALTOUS CHLORIDE (76) action 8510 adrenalectomized rats 8536 skeletal muscles bed 8510 adrenocortical activity 8536 sympathetic nerve stimulation 8510 erythrocyte Fe59 3 , 5-DICARBOMETHOXY-l , 2,3,4- incorporation 8536 TETRAHYDRO-2-NETHYL-9H-PYRID COCAINE (77) (3,4-b)IND0LE (PYRIDINDOLE II) administration routes 8516 pharmacologic properties (86) 8539 local anesthetics 8516 DICHLOROISOPROTERENOL (DCI) (87) relative toxicity 8516 acetyl strophanthi din CONVULSANTS (78) arrhythmias 8558 diazadamantane 8537 albino rabbits 8555 spinal inhibition 8537 amphetamine interaction 8555 spinal mechanisms 8537 anesthetized intact dogs 8558

S -8 SUBJECT INDEX 1961 DIC -ELE

antiarrhythmia activity 8558 DIPHENHYDRAMINE (94) blood pressure 8558 anticonvulsant activity 8556 cortical electrogenesis 8555 antitremor activity 8556 ECG 8558 tremorine analgesia 8556 EEC stimulant effects 8555 5 , 7-DIPHENYL-l ,3-DIAZADAMANTAN- isolated rabbit hearts 8558 6-OL (1757 1.5.) (95) ouabain arrhythmias 8558 convulsant action 8537 pentobarbital pretreatment 8555 spinal mechanisms 8537 phenoxybenzamine pretreatment 8555 DIURESIS, NERCURIAL (96) related dichloro compounds 8558 diabetes insipidus 8552 reserpine pretreatment 8555 dimercaprol effect 8552 Beta-DIETHYLANINOETHYL ( electrolyte reabsorption 8552 CHLORO-Alpha-METHYLBENZHYDRYL) free water clearance 8552 ETHER (KEITHON) (88) maximal water diuresis 8552 anticonvulsant effect 8556 mercaptomerin 8552 antitremor effect 8556 tubular action site 8552 chlorphenoxamine analogue 8556 unanesthetized dogs 8552 hexobarbital sleeping time 8556 water load 8552 tremorine analgesia 8556 DIURETICS (97) DIHYDRO-Beta-ERYTHROIDINE (89) aminophylline 8553 motoneuron recovery 8538 combined administration 8553 pentylenetetrazol 8538 hydrochlorothiazide 8553 Renshaw cell discharges 8538 mercaptomerin 8553 3 , 4-DIHYDROXYPHENYLALANINE renal chloride excretion 8553 (DOPA) (90) unanesthetized dogs 8553 brain catecholamine DOPAMINE (98) distribution 8543 catron 8543 catron modification 8543 dopa 8543 intravenous administration 8543 intracellular distribution 8543 melanin deposition 8543 pyrogallol 8543 pyrogallol modification 8543 rabbit brain 8543 reserpine 8543 reserpine 8543 toxicity 8543 tissue concentration 8543 DIMERCAPROL (91) DRUGS, ADMINISTRATION (99) chloride excretion 8552 absorption rate 8516 creatinine clearance 8552 concentration effects 8516 free water clearance 8552 local anesthetics 8516 maximal water diuresis 8552 mucous membrane applications 8516 mercurial diuresis 8552 toxicities 8516 PAH clearance 8552 DYES, FD&C (100) unanesthetized dogs 8552 aniline constituents 8548 urine flow 8552 metabolic fate 8548

,Beta-DIMETHYLACRYLYL- 2,4-meta-xylidine 8548 CHOLINE (SENECIOYLCHOLINE ,SCh) Red No. 1 8548 ganglionic stimulant (92)8527 split products 8548 pharmacologic properties 8527 1, 3-DIMETHYL-5-ETHYL-5-PHENYL HYDANTOIN (DIMETHYLNIRVANOL) ELECTROCARDIOGRAM (101) female dogs (93) 8545 ace tyl strophanthidin intravenous administration 8545 arrhythmias 8558 metabolic demethylation 8545 DCI reversal 8558 nirvanol formation 8545 ouabain arrhythmias 8558

S-9 SUBJECT INDEX ELE-ETH VOL. 132

ELECTROENCEPHALOGRAM (102) 5-hydroxytryptophan formation 8541 adrenergic blocking agents 8554 imipramine effect 8529 8555 intestinal mucosal cells 8541 amphetamine 8555 intracellular localization 8541 caffeine 8555 iproniazid inactivation 8529 carotid sinus denervation 8554 liver microsomal systems 8531 cat echol amine s 8554 MAO activity 8529 cortical electrogenesis 8554 monoamine oxidase 8542 8555 8543 curarized animals 8554 nikethamide enhancement 8546 dichloroi soproterenol 8554 pentobarbital metabolism 8546 8555 rabbit liver 8529 electrode implants 8555 rat liver microsomes 8546 evoked brain potentials 8515 rat tissues 8542 i soproterenol 8554 serotonin biosynthesis 8541 methylpheni date 8555 spider homogenate 8529 morphine 8515 tissue localization 8541 nalorphine 8515 tryptophan oxidation 8541 pentobarbital pretreatment 8555 tryptophan-5-hydroxylase pentylenetetrazol 8555 activity 8541 sciatic nerve stimulation 8515 EPINEPHRINE (106) spinal cord section 8554 adrenergic blocking agents 8554 stimulation patterns 8554 arterial strips 8507 8555 atropine influence 8507 thalamic stimulation 8515 contractile response 8507 tooth pulp stimulation 8515 curarized animals 8554 ELECTROLYTES (103) DCI pretreatment 8554 aminophyl 1 me 8553 EEC stimulant action 8554 diuretic agents 8553 ganglionic blocking agents 8507 renal excretion 8553 isolated atria 8523 unanesthetized dogs 8553 mecamylamine potentiation 8507 EMESIS, DRUG INDUCED (104) PIH pretreatment 8523 apomorphine 8540 pressor response 8507 copper sulfate 8540 TEA potentiation 8507 morphine antiemesis 8540 tissue concentrations 8506 phenazocine antiemesis 8540 triethyltin pretreatment 8506 ENZYMES (105) vagotomized pithed cats 8507 amphetamine catabolism 8529 ESCHERICHIA COLI (107) brain catecholamine amino acids-C14 8505 metabolism 8543 cell-free preparations 8547 catechol -O-methyltransferase 8542 chloramphenicol-H3 8505 8543 disrupted bacteria 8547 cyclizine stimulatory effect 8531 intact bacteria 8547 drug metabolism 8531 organic acids 8547 endogenous catecholamine oxidative metabolism 8547 accumulation 8542 pH sensitivity 8547 enzyme activity 8546 radioactivity distribution 8505 enzyme inhibitors 8542 ribonucleoprotein fraction 8505 8543 subcellular fractions 8505 exogenous norepinephrine ETHOPROPAZINE (108) metabolism 8542 anticonvulsant activity 8556 5-HTP decarboxylase 8541 antitremor activity 8556 tremorine analgesia 8556

S -10 SUBJECT INDEX 1961 ETH-HEA

ETHYL BISCOUMACETATE (TROMEX.AN) catecholamine content 8506 oxygen consumption (109) 8533 8542 rat liver slices 8533 COMT activity 8542 iproniazid pretreatment 8542 MAO activity 8542 FATTY ACIDS (110) norepinephrine metabolism 8542 albino rats 8522 pyrogallol pretreatment 8542 chlorpromazine pretreatment 8522 triethyltin 8506 meprobamate pretreatment 8522 tyramine metabolism 8542 periodic electric shock 8522 HEART ARRHYTHMIA , EXPERIMENTAL plasma levels 8522 acetylstrophanthidin induced 8558 stress response 8522 anesthetized intact dogs (116)8558 tranquilization 8522 DCI reversal 8558 epinephrine response 8558 heart rate 8558 GANGLIONIC BLOCKADE (111) insulin effect 8558 atropine response 8509 isolated perfused heart 8558 blood pressure 8527 isoproterenol response 8558 chlori sondamine 8509 ouabain induced 8558 hexamethonium induced 8527 vagal stimulation 8558 hexamethonium pretreatment 8509 ventricular tachycardia 8558 mecamylamine 8509 HEART AURICLES (117) neostigmine pressor response 8509 catecholamine content 8523 nictitating membrane 8527 chronotropic effects 8523 pentol inium 8509 DCI antagonism 8523 senecioylcholine response 8527 differential action 8523 tissue catecholamine release 8506 epinephrine 8523 triethyltin response 8506 inotropic effects 8523 trimethidinium induced 8506 iproniazid 8523 GANGLIONIC BLOCKING AGENTS (112) isolated guinea-pig atria 8523 arterial strips 8507 MAO activity 8523 chlorisondamine 8507 nicotine 8523 hexamethonium 8507 beta-phenylisopropylhydrazine 8523 mecamylamine 8507 reserpine influence 8523 pentolinium 8507 HEART, ISOLATED (118) potentiating effect 8507 acetyl strophanthidin tetraethylamrnonium 8507 arrhythmia 8558 vagotomized pithed cats 8507 acetyl strophanthi din vasoexcitatory agents 8507 ventricular tachycardia 8559 GANCLIONIC STIMULANTS (113) d-amphetamine 8558 McN-A-343 8526 antiarrhythmia activity 8559 pharmacologic properties 8526 contraction amplitude 8559 sympathetic nervous system 8526 DCI protective action 8558 D-CLUCOSE (114) isolated rabbit hearts 8559 borate toxicity 8560 isoproterenol 8558 borax:D-glucose molar ratios 8560 negative inotropic effect 8559 simultaneous administration 8560 nonionized procaine concentration 8559 perfused rabbit heart 8558 HEART (115) perfused turtle heart 8559 adrenalectomy 8506 perfusion pH values 8559 albino rats 8542 procaine cation concentration 8559

S -11 SUBJECT INDEX HEA-HYD VOL. 132

procaine effects 8559 keithon 8556 procaine ethylchloride cation 8559 liver microsomes 8531 refractory period 8559 inetabol sm 8531 stimulation threshold 8559 orphenadrine pretreatment 8531 ventricular conduction time 8559 phenobarbital pretreatment 8531 HEART MUSCLE FIBERS (119) pyridindole II prolongation 8539 ATP response 8525 sleeping time 8506 calcium response 8525 8531 8539 8556 contractile tension 8525 triethyltin effect 8506 extraction duration 8525 HIPPURIC ACID (125) fiber thickness 8525 concentration 8547 glycerol -extraction 8525 E. coli 8547 ouabain effect 8525 inhibitor activity 8547 pH influence 8525 intracellular pH 8547 phosphocreatine response 8525 ionized acid 8547 preincubat ion 8525 oxidative metabolism 8547 “relaxing factor” 8525 unionized acid 8547 HEART MUSCLE, ISOLATED (120) HISTAMINE (126) calcium influence 8524 ACTH secretion 8551 cat papillary muscles 8524 adrenal ascorbic acid 8551 ouabain effect 8524 anesthetized rats 8551 potassium influence 8524 arterial strips 8507 HEART RATE (121) “crude burn” material 8520 bradycardia 8540 heparin hydrolysates 8513 bretylium blockade 8526 mecamylamine potentiation 8507 dose effect 8540 morphine inhibitor activity 8551 McN-A-343 8526 nalorphine -morphine morphine 8540 antagonism 8551 phenazocine 8540 pyrilamine 8513 scopolamine blocking effect 8540 skin burns 8520 HEPARIN (122) smooth-muscle activity 8513 chemical analysis 8513 stress response 8551 heparin hydrolysates 8513 subcutaneous pocket histamine precursor 8513 di ffusates 8520 histamine-like response 8513 subcutaneous pocket histidine content 8513 perfusates 8520 polypeptide-like response 8513 TEA potentiation 8507 pyrilamine influence 8513 HORMONES (127) smooth-muscle activity 8513 adrenal medulla 8534 substance P 8513 catecholamine output 8534 HEXAMETHONIUM (123) epinephrine -norepinephrine atropine response 8509 ratio 8534 ganglionic blocking action 8509 selective secretion 8534 neostigmine pressor response 8509 HYDROCHLOROTHIAZIDE (128) HEXOBARBITAL (124) aminophylline combination 8553 adrenalectomy 8531 renal electrolyte excretion 8553 albino mice 8556 unanesthetized dogs 8553 barbital pretreatment 8531 HYDROCORTISONE (129) chlorcyclizine pretreatment 8531 adrenalectomized rats 8536 chlorphenoxamine 8556 adrenocortical steroids 8536 hypophysectomy 8531

S -12 SUBJECT INDEX 1961 HYD -LOB

17-HYDROXYCORTICOSTEROIDS (130) carotid sinus denervation 8554 abstinence intensity 8535 curarized rabbits 8554 human subjects 8535 DCI pretreatment 8554 morphine addiction 8535 EEC stimulant action 8554 plasma levels 8535 heart rate 8554 urinary excretion 8535 dl-2 ‘ -HYDROXY -5 , 9 -DIMETHYL-2 - PHENETHYL-6 , 7 -BENZOMORPHAN KIDNEY FUNCTION (139) (PHENAZOCINE) (131) arninophylline 8553 narcotic analgesic 8540 combined administration 8553 pharmacologic properties 8540 glomerular filtration rate 8553 HYDROXY-SULFINPYRAZONE (132) hydrochlorothiazide 8553 human subjects 8544 mercaptomerin 8553 intravenous administration 8544 tubular electrolyte plasma levels 8544 reabsorption 8553 sulfinpyrazone metabolite 8544 uricosuric activity 8544 urinary excretion 8544 LACRIMATION (140) 5-HYDROXYTRYPTOPHAN-3-C14 (133) chlorpromazine 8528 enzymic tryptophan oxidation 8541 comparative action 8528 serotonin biosynthesis 8541 reserpine 8528 HYPNOTICS (134) tetrabenazine 8528 albino mice 8539 LACTIC ACID (141) barbiturates 8539 concentration 8547 ethanol 8539 E. coli 8547 pyridindole II prolongation 8539 ionized acid 8547 sleeping time 8539 oxidative metabolism 8547 unionized acid 8547 LIDOCAINE (142) INIPRAMINE (TOFRANIL) (135) administration routes 8516 amphetamine catabolism 8529 local anesthetics 8516 amphetamine sensitivity 8529 relative toxicity 8516 MAO activity 8529 LIVER (143) spider web-building behavior 8529 albino rats 8542 IONIZATION, DRUG (136) COMT activity 8542 cardiac functions 8559 MAO activity 8542 isolated perfused hearts 8559 norepinephrine metabolism 8542 procaine 8559 LIVER MICROSOMES (144) IPRONIAZID (137) adult rats 8 546 amphetamine catabolism 8529 cyclizine stimulatory effects 8531 amphetamine sensitivity 8529 drug metabolism 8531 antinicotine effect 8523 enzyme activity 8531 antireserpine action 8523 hyperfunctional state 8546 DCI antagonism 8523 nikethamide pretreatment 8546 isolated atria 8523 pentobarbital metabolism MAO activity 8529 in vitro 8546 beta-phenylisopropylhydrazine 8523 tissue homogenates 8546 spider web-building behavior 8529 weanling rats 8546 ISOPROTERENOL (138) LOBELINE (145) adrenergic blocking agents 8554 anesthetized cats 8511 blood pressure 8554 cardiovascular system 8511

S -13 SUBJECT INDEX LOB -MET VOL. 132

comparative activity 8511 urine pH 8552 differential blockade 8511 water load 8552 intrathoracic receptors 8511 METABOLISM, DRUG (151) latent periods 8511 acetylsalicylic acid 8532 left ventricular injection 8511 d-amphetamine catabolism 8529 phenyldiguanide 8511 balance study 8530 respiration 8511 barbiturates 8531 right atrial injection 8511 8546 serotonin 8511 carboxytolbutamide excretion 8519 veratri dine 8511 chlorcyclizine-induced acceleration 8531 1 ,3-dimethyl hydantoin 8545 MANDELIC ACID (146) double demethylation 8545 concent rat ion 8547 enzyme activity 8542 E. coli 8547 FD&C dyes 8548 inhibitor activity 8547 FD&C Red No. I 8548 intracellular pH 8547 human subjects 8519 ionized acid 8547 8532 8544 oxidative metabolism 8547 imipramine effect 8529 unionized acid 8547 iproniazid effect 8529 MECAI4YLAMINE (147) kinetic analysis 8519 arterial strips 8507 laboratory animals 8532 blopd pressure 8507 liver microsomes 8531 potentiating effect 8507 male rats 8548 vascular effector cells 8507 MAO activity 8529 vasoexcitatory agents 8507 2,4-meta-xylidine 8548 ME PAZINE (148) methyl salicylate 8532 anticonvulsant activity 8556 3-methyl-MAE 8531 antitremor activity 8556 nikethamide effect 8546 tremorine analgesia 8556 nirvanol formation 8545

MEPROBAMATE (149) li -norepinephrine 8530 albino rats 8522 norepinephrine inactivation 8542 electric-shock stress 8522 oxidation in vivo 8519 plasma FFA 8522 pheny.butazone analogues 8544 tranquilizing action 8522 rat liver microsomes 8546 MERCAPTOMERIN (150) rat tissues 8542 aminophylline combination 8553 sleeping time 8546 ammonium chloride sodium salicylate 8532 pretreatment 8552 sulfinpyrazone 8544 chloride excretion 8552 tolbutamide administration 8519 dimercaprol effect 8552 zoxazolamine 8531 free water clearance 8552 2 , 4-META-XYLIDINE (152) glomerular filtration rate 8552 acetanilide conjugate 8548 maximal water diuresis 8552 male rats 8548 potassium excretion 8552 metabolic fate 8548 renal electrolyte excretion 8553 peroral administration 8548 renal plasma flow 8552 phenol test 8548 sodium excretion 8552 sulfamate conjugate 8548 unanesthetized dogs 8552 urinary excretion 8548 8553 urinary metabolites 8548 urine flow 8552

S-l4 SUBJECT INDEX 1961 MET -MUS

METHOXAMINE (153) histamine-induced stress 8551 adrenergic blocking agents 8554 inhibitor activity 8551 curarized animals 8554 nalorphine antagonism 8551 DCI pretreatment 8554 narcotic analgesics 8540 EEC stimulant action 8554 neural mechanisms 8515 METHYL SALICYLATE (154) phenazocine comparison 8540 human subjects 8532 tooth pulp stimulation 8515 hydrolysis in vitro 8532 MORPHINE ADDICTION (161) laboratory animals 8532 abstinence intensity 8535 metabolism 8532 human subjects 8535 oral toxicity 8532 hydrocortisone loading 8535 plasma concentrations 8532 17-hydroxycorticosteroids 8535 rat tissues 8532 plasma levels 8535 3 -METHYL-4-AMINOBENZOIC ACID urinary excretion 8535 acetanilide conjugate (155) 8548 MORPHINE-H3 (162) glycine conjugate 8548 biotransformation in vivo 8550 identification 8548 chromatographic experiments 8550 2,4-meta-xylidine metabolite 8548 conjugated form 8550 urinary excretion 8548 estimation procedure 8550 5 -METHYL -2-A.MINOBENZOIC ACID free form 8550 identification (156) 8548 male rats 8550 2,4-meta-xylidine metabolite 8548 normorphine formation 8550 Urinary excretion 8548 preparation method 8550 3 -METHYL-4-MONOMETHYLAMINO- urinary excretion 8550 AZOBENZENE (3-METHYL-MAE) (157) MIJCOSA, NASAL (163) chlorcyclizine pretreatment 8531 anesthetic efficiencies 8516 liver microsomes 8531 local anesthetics 8516 metabolism 8531 rabbit sneeze reflex 8516 MONOAMINE OXIDASE (158) relative toxicities 8516 amphetamine catabolism 8529 MUSCLE, SKELETAL (164) imipramine effect 8529 acetylcholine 8526 iproniazid inactivation 8529 8527 rabbit liver 8529 anticholinesterase activity 8514 spider homogenate 8529 antiveratrinic effect 8539 MONOAMINE OXIDASE INHIBITORS cat gastrocnemius 8514 iproniazid (159) 8523 cat tibialis anticus 8526 isolated guinea-pig atria 8523 contractures 8526 isoniazid 8523 isolated frog rectus beta-phenylisopropyihydrazine 8523 abdominis 8526 pyridindole II 8539 8527 MORPHINE (160) isolated frog sartorius 8539 ACTH secretion 8551 isometric twitch tension 8514 action site 8551 McN-A-343 8526 adrenal ascorbic acid 8551 neuromuscular junction 8526 analgesic action 8515 neuromuscular transmission 8514 anesthetized rats 8551 physostigmine 8527 central nervous system 8551 pyridindole II 8539 cortical responses 8515 quaternary ammonium compounds 8514 “drug-ratio” 8551 senecioylcholine 8527 evoked brain potentials 8515

S -15 SUBJECT INDEX MUS -NIC VOL. 132

MUSCLE, SMOOTH (165) cortical responses 8515 acetylcholine 8521 “drug-ratio” 8551 acetylcholine response 8526 evoked brain potentials 8515 8539 histamine-induced stress 8551 active substances 8520 morphine antagonist 8551 atropine 8521 morphine pretreatment 8515 atropine antagonism 8526 morphine-inhibited ACTH biological assays 8520 secretion 8551 cocaine 8521 narcotic analgesics 8540 colon motility 8540 phenazocine 8540 contraction response 8513 tooth pulp stimulation 8515 8521 2-NAPHTHYLGUANIDINE (167) diphenhydramine 8521 differential blocking action 8511 fetal placental extract 8521 lobeline depressor response 8511 ganglionic blocking agents 8507 phenyldiguanide responses 8511 guinea pig ileum 8513 NARCOTICS (168) 8520 8521 8539 comparative potency 8540 hen rectal cecum 8520 depressant effects 8540 heparin preparations 8513 morphine 8540 histamine 8521 phenazocine 8540 histamine comparison 8513 NEOSTIGMINE (169) 5-HT comparison 8513 action mechanism 8509 5 -hydroxyt ryptamine 8539 adrenalectomy 8509 isolated carotid strips 8507 adrenergic blockade 8509 isolated rabbit intestine 8539 anesthetized dogs 8509 isolated rabbit jejunum 8526 atropine 8509 isolated rat uterus 8539 ganglionic blockade 8509 McN-A-343 8526 phenoxybenzamine pretreatment 8509 muscle strip preparations 8521 pressor response 8509 neostigmine 8521 sympatholytic agents 8509 phenazocine 8540 beta-TM-lO pretreatment 8509 pyridindole II modification 8539 NEUROMUSCULAR JUNCTION (170) rabbit aorta 8521 ACh comparison 8526 rabbit intestine 8521 cat tibialis anticus 8526 rabbit uterus 8521 contracture responses 8526 rat aorta 8521 isolated frog rectus rat blood pressure 8520 abdominis 8526 rat duodenum 8520 McN-A-343 8526 rat uterus 8520 nicotine 8526 8521 d-tubocurarine antagonism 8526 reserpine pretreatment 8521 NICOTINE (171) serum cholinesterase 8521 iproniazid pretreatment 8523 skin burns 8520 isolated atria 8523 vasoexcitatory agents 8507 PIH pretreatment 8523 NICTITATINC MEMBRANE (172) anesthetized cats 8526 NALORPHINE (166) atropine antagonism 8526 adrenal ascorbic acid 8551 contraction response 8526 anesthetized rats 8551 8527 antagcnist activity 8540 DNPP comparison 8526

S -16 SUBJECT INDEX 1961 NIC -OUA

epinephrine 8527 tissue concentration 8506 hexamethonium pretreatment 8527 8543 intra-arterial injections 8526 triethyltin pretreatment 8506 intravenous administration 8526 3-NOREPINEPURINE (177) 8527 disappearance rate 8530 McN-A-343 8526 intravenous administration 8530 postganglionic nerve section 8526 laboratory animals 8530 preganglionic nerve section 8526 metabolic fate 8530 senecioylchol me 8527 plasma levels 8530 superior cervical tissue distribution 8530 ganglionectomy 8526 H3-NORMETANEPHRINE (178) NIKETH.ANIDE (173) H3-norepinephrine injection 8530 adult rats 8546 plasma levels 8530 barbiturate metabolism 8546 tissue distribution 8530 barbiturate sleeping time 8546 NORMORPHINE (179) peroral administration 8546 conjugated form 8550 rat liver microsomes 8546 estimation procedure 8550 repeated administration 8546 free form 8550 single dose 8546 male rats 8550 weanling rats 8546 morphine biotransformation NIRVANOL (174) in vivo 8550 1 ,3-dimethylnirvanol 3-NiiINE (180) administration 8545 conjugated form 8549 nirvanol administration 8545 estimation procedure 8549 urinary excretion 8545 fecal excretion 8549 NITROPHENOLS 175) female dogs 8549 oxygen consumption 8533 female monkeys 8549 rat liver slices 8533 free form 8549 NOREPINEPHRINE (176) physiologic disposition 8549 adrenergic blocking agents 8554 plasma levels 8549 arterial strips 8507 preparation method 8549 catron 8543 urinary excretion 8549 COlif inhibitors 8542 curarized animals 8554 DCI pretreatment 8554 ORGANIC ACIDS (181) dopa 8543 E. coli 8547 EEC stimulant action 8554 inhibitor activity 8547 endogenous accumulation 8542 intracellular biological intracellular distribution 8543 effects 8547 intravenous administration 8542 intracellular pH 8547 MAO inhibitors 8542 oxidative metabolism 8547 mecamylamine potentiation 8507 ORPHENADRINE (182) metabolism 8542 anticonvulsant activity 8556 o-methylation 8542 antitremor activity 8556 oxidative deamination 8542 tremorine analgesia 8556 plasma disappearance rate 8542 OUABAIN (183) pyrogallol 8543 action mechanism 8524 rabbit brain 8543 8525 rat tissues 8542 anaerobic conditions 8524 reserpine 8543 anesthetized intact dogs 8558 TEA potentiation 8507 calcium influence 8524

S -17 SUBJECT INDEX OUA-PER VOL. 132

contractile tension 8524 PARASYMPATHETIC NERVOUS SYSTEM, contracture response 8524 CENTRAL (188) DCI influence 8558 chl orpromazine 8528 glycerol-extracted fibers 8525 comparative effects 8528 heart arrhythmias 8558 lacrimation 8528 heart muscle 8525 pupil diameter 8528 inotropic stage 8524 reserpine 8528 muscle electrolyte content 8524 salivary secretion 8528 oxygen consumption 8524 t et rabenazine 8528 papillary muscles 8524 PARASYMPATHOLYTIC AGENTS (189) phosphate nucleotides 8524 amphetamine responses 8517 potassium influence 8524 atropine 8517 “relaxing factor” 8525 learned behavior 8517 toxic stage 8524 methyl atropine 8517 OXIME-ATROPINE (184) PENTOBARBITAL (190) albino rabbits 8512 action duration 8531 anticholinesterase poisoning 8512 adrenalectomy 8531 mortality studies 8512 albino mice 8539 organophosphorus compounds 8512 chlorcyclizine pretreatment 8531 treatment efficacy 8512 differential blocking action 8511 OXIMES (185) hypophysectomy 8531 acute toxicity 8512 liver microsomes 8531 antidotal effect 8512 lobeline depressor response 8511 atropine adjuvants 8512 metabolism 8531 cholinesterase reactivation 8512 metabolism in vitro 8546 sarin poisoning 8512 metabolism rate 8546 tabun poisoning 8512 nikethamide treated animals 8546 OXYGEN CONSUMPTION (186) pecking performance 8539 anticoagulant s 8533 phenobarbital pretreatment 8531 cation influence 8524 pigeon behavior 8539 E. coli 8547 pyridindole II pretreatment 8539 organic acids 8547 rat liver microsomes 8546 ouabain effect 8524 sleeping time 8539 papillary muscles 8524 8546 pH effect 8547 PENTYLENETETRAZOL (191) phosphate nucleotides 8524 aggregated mice 8518 rat liver slices 8533 amphetamine toxicity 8518 excitatory action 8538 interneuronal systems 8538 PAPILLARY MUSCLES (187) isolated mice 8518 calcium content 8524 motoneuron recovery 8538 cation influence 8524 recurrent inhibition 8538 contractile tension 8524 Renshaw cell discharges 8538 contracture response 8524 repetitive stimulation 8538 inotropic stage 8524 seizure threshold 8518 ouabain effect 8524 spinal cord 8538 oxygen consumption 8524 spinal synapses 8538 phosphate nucleotide content 8524 stimulus interval 8538 potassium content 8524 trimethadione antagonism 8538 sodium content 8524 PERFUSION, PRESSURE (192) toxic stage 8524 adrenergic blocking agents 8510

5-18 SUBJECT INDEX 1961 PER-PLA

blood flow responses 8510 Beta -PHENYLISOPROPYLHYDRAZINE constant level 8510 (CATRON,PIH) (200) skeletal muscle bed 8510 antinicotine effect 8523 PERIPHERAL RESISTANCE ,VASCULAR brain catecholamine adrenergic agents (193) 8510 distribution 8543 adrenergic blocking agents 8510 DCI antagonism 8523 blood flow responses . 8510 intravenous administration 8543 skeletal muscle bed 8510 iproniazid 8523 PHENAZOCINE (194) isolated atria 8523 analgesic tolerance 8540 reserpine 8543 analgesic -narcotic PHOSPHATES (201) dissociation 8540 cation influence 8524 antiemetic activity 8540 inorganic phosphate 8524 blood pressure 8540 ouabain effect 8524 cat excitatory effect 8540 papillary muscle content 8524 cat mydriasis 8540 phosphate nucleotides 8524 cross-tolerance 8540 PHOSPHATES ,ORGANIC (202) emetic effect 8540 anticholinesterase activity 8512 heart rate 8540 oxime-atropine antagonism 8512 morphine comparison 8540 sarin (GB) 8512 nalorphine antagonism 8540 tabun (GA) 8512 narcotic analgesics 8540 PHOSPHOCREATINE (203) pain threshold 8540 contractile tension 8525 respiration 8540 glycerol-extracted fibers 8525 smooth muscle 8540 heart muscle 8525 PHENINDIONE (195) “relaxing factor” 8525 oxygen consumption 8533 PLACENTAL EXTRACT (204) rat liver slices 8533 benactyzine 8521 PHENOBARBITAL (196) capillary permeability 8521 liver microsomes 8531 chemical characterization 8521 metabolism rate 8546 chlorpromazine 8521 nikethamide treated animals 8546 epinephrine 8521 rat liver microsomes 8546 inhibitor substances 8521 sleeping time 8546 norepinephrine 8521 TPNH metabolism 8531 peripheral activity 8521 PHENOXYBENZAMINE (197) procaine 8521 adrenergic blocking agent 8510 proteolytic enzymes 8521 amphetamine toxicity 8557 rabbit fetal placenta 8521 blocking effect 8509 smooth muscle-contracting blood flow responses 8510 principle 8521 ganglionic blockade 8509 vasodepressor principle 8521 neostigmine pressor response 8509 PLASMA (205) stressed animals 8557 ACTH response 8535 PHENYLBUTAZONE (198) albino rats 8542 human subjects 8544 dimethylnirvanol sulfinpyrazone formation 8544 administration 8545 thio analogue conversion 8544 disappearance rate 8542 PHENYLDIGUANIDE (199) 8544 intrathoracic receptors 8511 electric-shock stress 8522 lobeline comparison 8511 free fatty acid levels 8522

S -19 SUBJECT INDEX PLA-REC VOL. 132

human subjects 8535 Alpha-n-PROPYLANINO-2-METHYL- hydrocortisone disappearance PROPIONANILIDE (L 67,ASTRA) rate 8535 administration routes (210)8516 hydrocortisone infusion 8535 local anesthetics 8516 hydroxy-sul finpyrazone relative toxicity 8516 concentration 8544 PROTEIN,PLASMA (211) intravenous administration 8542 hydroxy-sulfinpyrazone 8544 binding 8544 iproniazid pretreatment 8542 sulfinpyrazone binding 8544 morphine addiction 8535 PUPIL (212) morphine withdrawal 8535 chlorpromazine 8528 nirvanol administration 8545 comparative effects 8528 nirvanol concentration 8545 reserpine 8528 norepinephrine concentration 8542 tetrabenazine 8528 norepinepheine metabolism 8530 PYRIDINDOLE (213) H3-norepinephrine levels 8530 albino mice 8539 H3-normetanephrine levels 8530 d-amphetamine stimulation 8539 normorphine-H3 concentration 8549 barbiturate depression 8539 l7-OHCS levels 8535 cardiovascular system 8539 pyrogallol pretreatment 8542 central nervous system 8539 subcutaneous administration 8549 MAO inhibitor activity 8539 tranquilizer pretreatment 8522 pecking performance 8539 tyramine concentration 8542 pigeon behavior 8539 POTASSIUM (206) skeletal muscle 8539 cat papillary muscles 8524 smooth muscle 8539 concentration effects 8524 substituted derivative 8539 “crude burn” material 8520 toxicity 8539 ouabain action 8524 PYROGALLOL (214) skin burns 8520 brain catecholamine subcutaneous pocket distribution 8543 diffusates 8520 catron 8543 PREDNISOLONE (207) intravenous administration 8543 adrenalectomized rats 8536 reserpine 8543 adrenocortical steroids 8536 erythrocyte Fe59 incorporation 8536 QUATERNARY AMMONIUM IONS (215) PROCAINE (208) anticholinesterase activity 8514 antiarrhythmia activity 8559 dose response 8514 cardiac functions 8559 neuromuscular transmission 8514 differential blocking action 8511 structure-activity studies 8514 ionization influence 8559 time-action curves 8514 isolated perfused hearts 8559 twitch depressing potencies 8514 lobeline responses 8511 twitch potentiating potensies 8514 phenvldiguanide responses 8511 serotonin responses 8511 veratridine responses 8511 RECEPTORS , INTRATHORACIC (216) PROCYCLIDINE (209) cardiovascular system 8511 anticonvulsant activity 8556 lobeline 8511 antitremor activity 8556 phenyldi guani de 8511 tremorine analgesia 8556 respiration 8511

S -20 SUBJECT INDEX 1961 REC -SER

serotonin 8511 reflex apnea 8511 veratri dine 8511 serotonin comparison 8511 REFLEXES ,SPINAL CORD (217) tidal volume 8540 anesthetized spinal cats 8537 diazadamantane augmentation 8537 dorsal root stimulation 8537 SALICYLATE (220) polysynaptic discharge 8537 acetylsalicylic acid 8532 spinal inhibition blockade 8537 brain concentrations 8532 RESERPINE (218) comparative toxicity 8532

action mechanism 8543 human subjects . 8532 atropine blocking effect 8528 laboratory animals 8532 brain catecholamine metabolism 8532 distribution 8543 methyl salicylate 8532 catechol -0-methyltransferase 8543 oral administration 8532 catron modification 8543 oxygen consumption 8533 central parasympathetic plasma concentrations 8532 activity 8528 rat liver slices 8533 chlorisondamine unfluence 8528 sodium salicylate 8532 depressant activity 8523 SALICYLATE,SODIUM (221) eyelid responses 8528 laboratory animals 8532 hexamethonium blocking effect 8528 metabolism 8532 intravenous administration 8543 oral toxicity 8532 iproniazid pretreatment 8523 SALIVARY SECRETION (222) isolated atria 8523 amphetamine response 8528 1 ac r imat i on 8528 anesthesia influence 8528 light-reflex facilitation 8528 atropine influence 8528 MAO inhibitors 8523 chlorisondamine influence 8528 miotic action 8528 chlorpromazine 8528 monoamine oxidase 8543 chorda tympani section 8528 optic nerve section 8528 comparative effects 8528 parasympathetic denervation 8528 reserpine 8528 peripheral norepinephrine tetrabenazine 8528 depletion 8528 SARIN POISONING (223) PIH pretreatment 8523 anticholinesterase activity 8512 pupilloconstrictor-center experimental animals 8512 stimulation 8528 oxime-atropine treatment 8512 pyrogallol modification 8543 SENECIOYLCHOLINE (224) salivary secretion 8528 ganglionic stimulant 8527 sympathetic denervation 8528 pharmacologic properties 8527 tissue catecholamine release 8506 structure-action relationship 8527 triethyltin comparison 8506 SEROTONIN (225) RESPIRATION (219) arterial strips 8507 anesthetized dogs 8526 intrathoracic receptors 8511 depressant effects 8540 lobeline comparison 8511 lobeline response 8511 mecamylarnine potentiation 8507 McN-A-343 8526 skin burns 8520 minute volume 8540 subcutaneous-pocket morphine 8540 diffusates 8520 phenazoc me 8540 TEA potentiation 8507 phenyldiguanide comparison 8511 SEROTONIN-3-C14 (226) rate changes 8540 biosynthesis 8541

S -21 SUBJECT INDEX SER-SYM VOL. 132

enzymic tryptophan oxidation 8541 adrenal ascorbic 8551 5-hydroxytryptophan formation 8541 adrenalectomy 8557 SKIN (227) adult male rats 8557 active substance release 8520 aggregation situation 8557 air pouch technique 8520 albino mice 8557 radiant heat 8520 albino rats 8522 subcutaneous -pocket amphetamine toxicity 8557 diffusates 8520 anesthetized rats 8551 subcutaneous -pocket aversive electric shock 8557 . perfusates 8520 chlorpromazine effect 8557 thermal injury 8520 electric shock induced 8522 water bath immersion 8520 exhaustion syndrome 8557 SPIDERS (228) histamine induced 8551 amphetamine catabolism 8529 morphine inhibitor activity 8551 amphetamine sensitivity 8529 nalorphine -morphine imipramine pretreatment 8529 antagonism 8551 iproniazid pretreatment 8529 phenoxybenzamine effect 8557 web-building behavior 8529 plasma FFA 8522 SPINAL CORD (229) tranquilizing agents 8522 anesthetized spinal cats 9537 SULFINPYRAZONE (ANTURANE) (232) C6 transection 8506 human subjects 8544 diazadamantane effects 8537 hydroxy- sul finpyrazone dorsal root stimulation 8537 metabolite 8544 excitatory effect 8538 metabolic studies 8544 monosynaptic reflexes 8537 oral administration 8544 8538 phenylbutazone thio analogues 8544 pentylenetetrazol 8538 uricosuric activity 8544 polysynaptic discharge 8537 urinary excretion 8544 polysynaptic reflexes 8537 SYMPATHETIC NERVOUS SYSTEM (233) 8538 adrenal ectomy 8509 reflex activity 8537 8526 spinal inhibition blockade 8537 bilateral sympathectomy 8526 strychnine comparison 8537 ganglionic stimulants 8526 synaptic recovery 8538 hypothalamo-adrenal discharge 8506 tissue catecholamine release 8506 McN-A-343 response 8526 triethyltin effect 8506 neostigmine response 8509 trimethadione 8538 pi 1 oerec t ion 8506 SPLANCHNIC NERVES (230) surgical exclusion 8509 action potentials 8534 sympathectomy 8509 adrenal medullary discharge 8534 triethyltin stimulation 8506 anesthetized dogs 8534 SYMPATHETIC NERVOUS SYSTEM, blood pressure 8534 PERIPHERAL (234) electrical stimulation 8534 adrenergic blocking agents 8510 localized thermal blockade 8534 blood flow responses 8510 partial nerve section 8534 lumbar nerve stimulation 8510 selective catecholamine SYMPATHOLYTIC AGENTS (235) secretion 8534 ganglionic blockade 8509 stimulation frequency 8534 neostigmine pressor response 8509 stimulation intensity 8534 beta-TM-lO 8509 STRESS (231) SYMPATHOMIMETIC AGENTS (236) ACTH secretion 8551 albino mice 8517

S-22 SUBJECT INDEX 1961 SYM-TRI

amphetamine 8517 TOOTH PULP (244) atropine-induced decamethonium-prepared dogs 8515 augment at ion 8517 evoked brain potentials 8515 learned behavior 8517 morphine 8515 methyl atropine 8517 nalorphine 8515 single shock stimulation 8515 TRANQUILIZATION (245) TABUN POISONING (237) albino rats 8522 anticholinesterase activity 8512 chlorpromazine induced 8522 experimental animals 8512 electric-shock stress 8522 oxime-atropine treatment 8512 meprobamate induced 8522 TETRABENAZINE (238) plasma FFA 8522 central parasympathetic TRANSMISSION ,NEUROMUSCULAR (246) activity 8528 cat gastrocnemius 8514 light reflex sensitivity 8528 ChE inhibition factor 8514 miotic action 8528 drug-induced facilitation 8514 TETRACAINE (239) quaternary ammonium compounds 8514 administration routes 8516 twitch potentiation 8514 local anesthetics 8516 TRANSMISSION ,SYNAPTIC (247) relative toxicity 8516 gamnia-aminobutyric acid 8508 TETRAETHYLANMONIUM (240) autonomic ganglia 8508 arterial strips 8507 decerebrate cats 8508 blood pressure 8507 inferior mesenteric ganglion 8508 differential blocking action 8511 pentylenetet razol 8538 lobeline responses 8511 postganglionic action phenyldiguanide responses 8511 potentials 8508 potentiating effect 8507 spinal synapses 8538 serotonin responses 8511 superior cervical ganglion 8508 vascular effector cells 8507 trimethadione 8538 vasoexcitatory agents 8507 TRIETHYLTIN (248) THYMIJS (241) blood pressure responses 8506 adrenalectomized rats 8536 central nervous system 8506 adrenocortical steroids 8536 female rats 8506 thymolytic activity 8536 ganglionic blockade 8506 thymus weight 8536 hexobarbital sleeping time 8506 TISSUE ,DANACE (242) hyperglycemia 8506 active substance release 8520 piloerection 8506 skin burns 8520 reserpine comparison 8506 thermal injury 8520 spinal cord section 8506 TOLBUTAMIDE (243) tissue catecholamine release 8506 carboxytolbutamide excretion toxicity 8506 kinetcs 8519 TRIHEXYPHENIDYL (249) free acid ingestion 8519 anticonvulsant activity 8556 human subjects 8519 antitremor activity 8556 intravenous injection 8519 tremorine analgesia 8556 metabolism 8519 TRIMETHADIONE (250) metabolite excretion 8519 pentylenetet razol 8538 oxidation in vivo 8519 spinal cord 8538 urine volume 8519 synaptic transmission 8538

S-23 SUBJECT INDEX TR-ZOX VOL. 132

DL-TRYPTOPHAN-3-Cl4 (251) VERATRIDINE (255) enzymic oxidation 8541 intrathoracic receptors 8511 hydroxylation dependencies 8541 lobeline comparison 8511 5-hydroxytryptophan formation 8541 serotonin biosynthesis 8541 WARFARIN (256) oxygen consumption 8533 VASODEPRESSOR AGENTS (252) rat liver slices 8533 fetal placental extract 8521 hypotensive principle 8521 rabbit placenta 8521 smooth muscle-contracting XANTHINES (257) principle 8521 ammnophylline 8553 VASOEXCITATORY AGENTS (253) renal function 8553 ganglionic blocking agents 8507 tubular electrolyte isolated arterial strips 8507 reabsorption 8553 tachyphylaxis 8507 vagotomized pithed cats 8507 VASOMOTOR RESPONSES (254) adrenergic agents 8510 ZOXAZOLAMINE (258) adrenergic blocking agents 8510 action duration 8531 blood flow responses 8510 chlorcyclizine pretreatment 8531 skeletal muscle bed 8510 liver microsomes 8531 sympathetic nerve stimulation 8510 metabolism 8531

S-24 AUTHOR INDEX 1961 VOL. 132

Abreu B E 8556 Goldstein L 8554 Pepeu C 8523 Astrom A 8516 8555 Persson N H 8516 Axelrod J 8530 Green H D 8510 Posner H S 8543 Green J P 8513 Baird W N 8559 Rapela C E 8510 Baucum R 8546 Hardman H F 8558 Rashleigh P L 8507 Begley R W 8556 8559 Richards A B 8556 Bevan J A 8511 Harris L S 8539 Riggs D S 8552 Blanton F L 8557 Hilton J C 8509 Riker W F 8514 Bogdanski D F 8528 Holland W C 8527 Roberts B J 8508 Boris A P 8529 Roberts M 8513 Bowles C R 8543 Jacoby H I 8549 8523 Brazda F C 8546 Jones A H 8512 Rocha E Silva M 8520 Brettschneider L 8529 Rosenthal S R 8520 Brodie B B 8528 Kerley T L 8556 Ross S D 8540 Brody T M 8506 Kunkel A M 8512 Roszkowski A P 8526 Brooks J W 8535 Kuperman A S 8514 Burdette B H 8551 Burns J J 8531 Landrau M 8544 Schanberg S 8523 8544 Laties V C 8557 Sekul A A 8527 Burstein R 8524 Lee D I 8524 Shemano I 8540 Burton R N 8521 Lee K S 8524 Sicam L E 8544 Butler T C 8545 8525 Sisson J A 8521 Leeman S 8551 Smith D 8521 Carlton P L 8517 Lewin J 8538 Smith P K 8532 Carter C E 8505 Lindstrom H V 8548 Sulser F 8528 Chin J H 8515 Longo V C 8537 Swinyard E A 8518 Clark L D 8518 Lucchesi B R 8558 Conney A H 8531 Lum B K B 8507 Cooper J R 8541 Udenfriend S 8542 Creveling C R 8542 Uhle F C 8539 Crout J R 8542 Mallov S 8522 Matthews R J 8508 Verity M A 8511 Davies J 8521 Melcer I 8541 Davison C 8532 Michaelson I A 8531 Waddell W J 8545 Day N 8513 Miller T B 8552 Weaver L C 8556 Dayton P C 8544 Mirkin B L 8534 Weil-Malherbe H 8530 Didamo P 8517 Misra A L 8549 8543 Domino E F 8515 8550 Weiner N 8547 Draskoczy P 8547 Miyahara J T 8518 Weiss B 8557 Moore K E 8506 Wendel H 8540 Easterday 0 D 8560 Mul S J 8550 Whitby L C 8530 Eisenman A J 8535 Munoz C 8554 Witt P N 8522 Esplin D W 8538 8555 8529 Munson P L 8551 Wolf H H 8518 Farr L E 8560 Woods L A 8549 Felsenfeld H 8505 8550 Fisher J W 8536 Nechay B R 8553 Wosilait W D 8533 Fraser H F 8535 Nelson E 8519 Yu D H 8524 Giarman N J 8523 O’Leary J F 8512 Gill E W 8514 O’Reilly I 8519 Zimmerman E F 8532 A-l 1961 NOTICE VOL. 132 to Subscribers and Readers Because of the comprehensive nature of the Journal index, the following explanatory comment, with special reference to subject analysis, seems ap- propriate at this time. Sublect Content: This is available to the reader through simple, coordin- ate search of the Subject Index. Coincident display of pertinent headings and subheadings, arranged alphabetically, assures the searcher that signif- icant information will not bemissed. The information thus acquired may be divided into three categories: First: The Number of Articles Cited on Each Subject. Rapid survey of the entry numbers listed opposite the subheadings will indicate the scope and variety of topic coverage. The subheadings describe the subject content in unit terms, with separate access afforded for each idea. For the convenience of direct page reference, AUXILIARY INDEX-PART I presents a table of Index to Pages. Second: The Number of Subjects Covered in Each Article. The Subject Index admits topic headings according to the relative impor- tance of the competing information in each article, and by careful selec- tion, the duplication of subject headings is minimized, without sacrificing essential flexibility. By the liberal use of such headings, numbered ser- ially in parenthesis, complete cross-reference is simple and productive, free from the accumulation of cumbersome “see” and “see also” listings in conimon use. For the purpose of cross-reference the short index of alternative headings represented in AUXILIARY INDEX-PART II is recommended. The appropriate head- ia& numbers are arranged below the underscored entry numbers, and can be quickly located by first consulting the parenthetic numbers in the Subject Index. Third: The Associations of Ideas Related to the Subject of Search. Ready comparison of ideas described under one heading with those listed under the alternative headings will often lead to a fund of relevant facts. In this manner, tracing ideas through the total system should open the way to useful material that is beyond the limits of restricted fields of inquiry. Auxiliary Index-Part I Index to Pages VOLUME 132, 1961 APRIL MAY JUNE Entry ag Entry Entry 3505 1 8523 131 8541 265 8506 6 8524 139 8542 269 8507 13 8525 149 8543 278 8508 19 8526 156 8544 287 8509 23 8527 171 8545 291 8510 29 8528 176 8546 295 8511 42 8529 183 8547 299 8512 50 8530 193 8548 306 8513 58 8531 202 8549 311 8514 65 8532 207 8550 317 8515 74 8533 212 8551 323 8516 87 8534 218 8552 329 8517 91 8535 226 8553 339 8518 97 8536 232 8554 345 8519 103 8537 240 8555 354 8520 110 8538 245 8556 360 8521 117 8539 251 8557 366 8522 126 8540 258 8558 372 8559 382 8560 392 Al -1 1961 Auxiliary Index-Part II VOL. 132 Index to Subject Headings

8505 8509 8513 8519 8524 8528 8533 8539 8543 8549 8555 19 64 126 243 186 222 195 67 200 205 102 30 111 165 187 238 220 86 214

68 123 201 #{149} 256 124 218 8550 8556 107 169 8514 8520 206 8529 134 162 24 197 32 9 23 159 179 34 233 73 49 105 164 8544 38

235 164 56 8 135 11 165 132 8551 39 12 215 58 59 137 53 190 151 7 41 13 246 126 119 151 65 213 198 11 48 57 14 165 183 158 127 205 40 61 65 16 206 203 228 230 211 67 71

67 44 225 232 126 79 106 52 25 227 8535 25 160 81 111 53 53 242 8526 8530 7 35 8545 166 88 115 85 57 13 65 10 53 82 231 94 124 192 67 41 151 51 104 93 108 176 193 102 53 42 177 130 121 151 8552 124 218 197 160 60 52 178 161 131 174 83 148 229 234 166 165 53 205 205 160 205 91 182 233 254 244 204 64 165 96 209 248 252 70 8531 166 150 249 8516 113 45 8536 168 8546 1 121 46 17 194 45 8553 8557 53 26 _.aa164 69 37 219 46 6 13 27 64 77 67 165 105 74 105 18 16 47 145 99 72 170 124 75 8541 144 21 22 53 167 142 110 172 144 76 105 151 97 72 106 190 163 149 219 151 129 133 173 103 197 112 199 210 205 233 157 207 226 190 128 231 126 208 239 231 190 241 251 196 139 147 216 245 8527 196 150 8558 165 219 13 258 8537 8547 257 5 176 225 8517 8523 15 78 8542 3 29 225 240 23 66 53 84 57 107 8554 53 240 255 41 106 92 8532 95 65 125 14 87 253 67 117 111 4 217 105 141 16 101 aa 189 137 164 151 229 115 146 53 116 31 236 159 172 154 143 181 57 118

--- 41 171 224 220 151 186 65 183 20 184 8518 200 221 8538 176 102 42 185 22 218 89 205 8548 106 8559 247 202 54 8528 8533 191 100 138 29 223 67 43 2 229 8543 151 153 118 237 191 8524 57 33 247 57 152 176 136 13 28 72 50 250 65 155 208 15 59 140 80 90 156 8555 32 8513 8519 63 188 109 8539 98 16 8560 41 36 62 120 212 175 23 105 8549 22 55 53 122 151 183 218 186 64 176 180 87 114

AI-2 NOTICE to Subscribers and Readers Attention is directed to the current method (ACC) of using entry numbers opposite the unit terms and names comprising the Subject and Author sections of the Journal Index. These entry numbers coincide with the appropriate accession numbers listed serially at the left of the titles in the Register of Articles. Their purpose is to condense and unify the three parts of the index, and to expedite its use. For a brief guide to the use of the current index please consult pages AI-l, and AI-2. Objectives and method are discussed under Notice to Readers and Subscribers. For direct page reference, an Index to Pages by entry numbers is tabulated on page AI-l. For cross-reference of subject matter, an index to Subject Headings by entry numbers is presented on page AI-2.

The possibility has been considered that additional copies of the index, bound separately, might be of value to libraries and to other subscribers and readers for use in reference work. Such a separate distribution would be justified only if the sale of a significant number of copies could be assured. It is suggested that anyone interested in such separate indexes write a letter to the Publisher who can then determine the feasibility of separate distribution.

AI-3