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Environmental Protection Agency § 180.3

(j) The term negligible residue means (1) Any raw agricultural commodity any amount of a chemical re- ( or feed) as defined in section maining in or on a raw agricultural 201(r) of the Federal Food, Drug, and commodity or group of raw agricul- Cosmetic Act (FFDCA); and tural commodities that would result in (2) Any processed food or feed as de- a daily intake regarded as fined in section 201(gg) of the FFDCA. toxicologically insignificant on the basis of scientific judgment of ade- [36 FR 22540, Nov. 25, 1971] quate safety data. Ordinarily this will EDITORIAL NOTE: For FEDERAL REGISTER ci- add to the diet an amount which will tations affecting § 180.1, see the List of CFR be less than 1/2,000th of the amount Sections Affected, which appears in the that has been demonstrated to have no Finding Aids section of the printed volume and at www.fdsys.gov. effect from feeding studies on the most sensitive animal species tested. Such § 180.3 Tolerances for related pesticide studies shall usually include chemicals. at least 90-day feeding studies in two species of mammals. (a) Pesticide chemicals that cause re- lated pharmacological effects will be (k) The term nonperishable raw agri- regarded, in the absence of evidence to cultural commodity means any raw agri- the contrary, as having an additive del- cultural commodity not subject to eterious action. (For example, many rapid decay or deterioration that would pesticide chemicals within each of the render it unfit for consumption. Exam- following groups have related pharma- ples are cocoa beans, coffee beans, cological effects: Chlorinated organic field-dried beans, field-dried peas, , arsenic-containing chemi- grains, and nuts. Not included are eggs, cals, metallic dithiocarbamates, cho- milk, meat, poultry, fresh fruits, and linesterase-inhibiting pesticides.) vegetables such as onions, parsnips, po- (b) Tolerances established for such tatoes, and carrots. related pesticide chemicals may limit (l) The term tolerance with regional the amount of a common component registration means any tolerance which (such as As2O3) that may be present, or is established for pesticide residues re- may limit the amount of biological ac- sulting from the use of the pesticide tivity (such as inhibi- pursuant to a regional registration. tion) that may be present, or may limit Such a tolerance is supported by res- the total amount of related pesticide idue data from specific growing regions chemicals (such as chlorinated organic for a raw agricultural commodity. Indi- pesticides) that may be present. vidual tolerances with regional reg- (c)(1) Where tolerances for inorganic istration are designated in separate bromide in or on the same raw agricul- subsections in 40 CFR 180.101 through tural commodity are set in two or 180.999, as appropriate. Additional res- more sections in this part (example: idue data which are representative of §§ 180.123 and 180.199), the overall quan- the proposed use area are required to tity of inorganic bromide to be toler- expand the geographical area of usage ated from use of the same pesticide in of a pesticide on a raw agricultural different modes of application or from commodity having an established ‘‘tol- two or more pesticide chemicals for erance with regional registration.’’ which tolerances are established is the Persons seeking geographically broad- highest of the separate applicable tol- er registration of a crop having a ‘‘tol- erances. For example, where the bro- erance with regional registration’’ mide tolerance on asparagus from should contact the appropriate EPA methyl bromide commodity fumigation product manager concerning additional is 100 parts per million (40 CFR 180.123) residue data required to expand the use and on asparagus from methyl bromide area. soil treatment is 300 parts per million (m) The term pesticide chemical res- (40 CFR 180.199), the overall inorganic idue shall have the meaning specified bromide tolerance for asparagus grown in FFDCA section 201(q)(2), as amend- on methyl bromide-treated soil and ed, except as provided in § 180.4. also fumigated with methyl bromide (n) The term food commodity means: after harvest is 300 parts per million.

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(2) Where tolerances are established ceed that permitted by the highest tol- in terms of inorganic bromide residues erance established for any one member only from use of organic bromide fumi- of the class, calculated as zinc gants on raw agricutural commodities, ethylenebisdithiocarbamate. such tolerances are sufficient to pro- (6) Where tolerances are established tect the public health, and no addi- for residues of both S,S,S-tributyl tional concurrent tolerances for the or- phosphorotrithioate and tributyl ganic pesticide chemicals from such phosphorotrithioite in or on the same use are necessary. This conclusion is raw agricultural commodity, the total based on evidence of the dissipation of amount of such pesticides shall not the organic pesticide or its conversion yield more residue than that permitted to inorganic bromide residues in the by the higher of the two tolerances, food when ready to eat. calculated as S,S,S-tributyl (d)(1) Where tolerances are estab- phosphorotrithioate. lished for both calcium and hy- (7) Where tolerances are established drogen cyanide on the same raw agri- for residues of O,S-dimethyl cultural commodity, the total amount phosphoramidothioate, resulting from of such pesticides shall not yield more the use of (O,S-dimethyl residue than that permitted by the acetylphos-phoramidothioate) and/or larger of the two tolerances, calculated O,S - dimethylphosphoramidothioate on as hydrogen cyanide. the same agricultural commodity, the (2) Where tolerances are established total amount of O,S-dimethyl- for residues of both O,O-diethyl S-[2- phosphoramidothioate shall not yield (ethylthio)ethyl] phosphorodithioate more residue than that permitted by and (a mixture of O,O-diethyl the higher of the two tolerances. O-(and S-) [2-(ethylthio)ethyl] (8) Where a tolerance is established phosphorothioates) on the same raw for more than one pesticide having the agricultural commodity, the total metabolites 1-(3,4-dichlorophenyl)-3- amount of such pesticides shall not methylurea (DCPMU) and 3,4- yield more residue than that permitted dichlorophenylurea (DCPU) found in or by the larger of the two tolerances, cal- on a raw agricultural commodity, the culated as demeton. total amount of such residues shall not (3) Where tolerances are established exceed the highest established toler- for both terpene polychlorinates ance for a pesticide having these me- (chlorinated mixture of camphene, pi- tabolites. nene, and related terpenes, containing (9) Where a tolerance is established 65–66 percent chlorine) and for more than one pesticide having as (chlorinated camphene containing 67–69 metabolites compounds containing the percent chlorine) on the same raw agri- benzimidazole moiety found in or on a cultural commodities, the total raw agricultural commodity, the total amount of such pesticides shall not amount of such residues shall not ex- yield more residue than that permitted ceed the highest established tolerance by the larger of the two tolerances, cal- for a pesticide having these metabo- culated as a chlorinated terpene of mo- lites. lecular weight 396.6 containing 67 per- (10) Where a tolerance is established cent chlorine. for triclopyr, chloropyrifos, and (4) Where a tolerance is established -methyl having the com- for more than one pesticide containing mon metabolite 3,5,6-trichloro-2- arsenic found in, or on a raw agricul- pyridinol on the same raw agricultural tural commodity, the total amount of commodity, the total amount of such such pesticide shall not exceed the residues shall not exceed the highest highest established tolerance cal- established tolerance for any of the culated as As2O3. pesticides having the metabolites. (5) Where tolerances are established (11) Where tolerances are established for more than one member of the class for more than one pesticide having the of dithiocarbamates listed in para- metabolite 3,5,6-trichloro-2-pyridinol graph (e)(3) of this section on the same found in or on the raw agricultural raw agricultural commodity, the total commodity, the total amount of such residue of such pesticides shall not ex- residues shall not exceed the highest

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established tolerance for a pesticide (ii) Deduct the amounts of such resi- having this metabolite. dues from the total amount of residues (12) Where tolerances are established present and consider the remainder to for residues of , resulting have the same tolerance as that for the from the use of thiodicarb and/or chemical having the lowest numerical methomyl on the same raw agricul- tolerance in that class. tural commodity, the total amount of (iii) Divide the quantity of each de- methomyl shall not yield more residue terminable residue by the tolerance than that permitted by the higher of that would apply if it occurred alone the two tolerances. and the quantity of the remaining res- (e) Except as noted in paragraphs idue by the tolerance for the chemical (e)(1) and (2) of this section, where resi- having the lowest numerical tolerance dues from two or more chemicals in the in that class and multiply by 100 to de- same class are present in or on a raw termine the percentage of the per- agricultural commodity the tolerance mitted amount of residue present. for the total of such residues shall be (iv) Add the percentages so obtained the same as that for the chemical hav- for all residues present. ing the lowest numerical tolerance in (v) The sum of the percentages shall this class, unless a higher tolerance not exceed 100 percent. level is specifically provided for the (3) The following pesticides are mem- combined residues by a in bers of the class of dithiocarbamates: this part. (1) Where residues from two or more A mixture of 5.2 parts by weight of ammoni- ates of [ethylenebis (dithiocarbamato)] chemicals in the same class are present zinc with 1 part by weight ethylenebis in or on a raw agricultural commodity [dithiocarbamic acid] bimolecular and and there are available methods that trimolecular cyclic anhydrosulfides and permit quantitative determination of disulfides. each residue, the quantity of combined 2-Chloroallyl diethyldithiocarbamate. residues that are within the tolerance Coordination product of zinc ion and maneb may be determined as follows: containing 20 percent manganese, 2.5 per- (i) Determine the quantity of each cent zinc, and 77.5 percent ethylenebisdithiocarbamate. residue present. Ferbam. (ii) Divide the quantity of each res- Maneb. idue by the tolerance that would apply Manganous dimethyldithiocarbamate. if it occurred alone, and multiply by Sodium dimethyldithiocarbamate. 100 to determine the percentage of the Thiram. permitted amount of residue present. Zineb. (iii) Add the percentages so obtained Ziram. for all residues present. (4) The following are members of the (iv) The sum of the percentages shall class of chlorinated organic pesticides: not exceed 100 percent. (2) Where residues from two or more . chemicals in the same class are present BHC ( hexachloride). in or on a raw agricultural commodity 1,1-Bis(p-chlorophenyl)-2,2,2- trichloroethanol. and there are available methods that Chlorbenside (p-chlorobenzyl p-chlorophenyl permit quantitative determinations of sulfide). one or more, but not all, of the resi- . dues, the amounts of such residues as Chlorobenzilate (ethyl 4,4′- may be determinable shall be deducted dichlorobenzilate). from the total amount of residues p-Chlorophenoxyacetic acid. present and the remainder shall have p-Chlorophenyl-2,4,5-trichlorophenyl sulfide. the same tolerance as that for the 2,4-D (2,4-dichlorophenoxyacetic acid). chemical having the lowest numerical DDD (TDE). tolerance in that class. The quantity of DDT. 1,1-Dichloro-2,2-bis(p-ethylphenyl) ethane. combined residues that are within the 2,6-Dichloro-4-nitroaniline. tolerance may be determined as fol- 2,4-Dichlorophenyl p-nitrophenyl ether. lows: . (i) Determine the quantity of each Dodecachlorooctahydro-1,3,4-metheno-2H- determinable residue present. cyclobuta[cd]pentalene.

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Endosulfan (6,7,8,9,10,10-hexachloro-1,5,5a, 2-Chloro-1-(2,4,5-trichlorophenyl)vinyl di- 6,9,9a-hexahydro-6,9-methano-2,4,3- methyl phosphate. benzodioxathiepin-3-oxide). 2-Chloro-1-(2,4-dichlorophenyl) vinyl diethyl (6,7,8,9,10,10-hexachloro- phosphate. 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3- (O,O-diethyl O-3-chloro-4-meth- benzodioxathiepin-3,3-dioxide). yl-2-oxo-2H-1-benzopyran-7-yl phosran-7-yl (1,4,5,6,7,8,8-heptachlor-3a,4,7, 7a- phosphate). tetrahydro-4,7-methanoindene). Coumaphos oxygen analog (O,O-diethyl O-3- Heptachlor epoxide (1,4,5,6,7,8,8-heptachloro- chloro-4-methyl-2-oxo-2H-1- 2,3-epoxy-2,3,3a,4,7,7a-hexahydro-4,7- benzopyphorothioate). methanoindene). (S-(2-chloro-1-phthalimidoethyl) Hexachlorophene (2,2′-methylenebis(3,4,6- O,O-diethyl phosphorodithioate). trichlorophenol) and its monosodium . Dialifor oxygen analog (S-(2-chloro-1- ′ Isopropyl 4,4 -dichlorobenzilate. phthalimidoethyl) O,O-diethyl . phosphorothioate). . Demeton (a mixture of O,O-diethyl O-(and S) Ovex (p-chlorophenyl p- [2-ethylthio)ethyl] phosphorothioates). chlorobenzenesulfonate). Ethiolate (S-ethyl diethylthiocarbamate). Sesone (sodium 2,4-dichlorophenoxyethyl 2,2-Dichlorovinyl dimethyl phosphate. sulfate, SES). O,O-Diethyl S-[2-(ethylthio)ethyl] Sodium 2,4-dichlorophenoxyacetate. phosphorodithioate and its cholinesterase- Sodium trichloroacetate. Sulphenone (p-chlorophenyl phenyl ). inhibiting metabolites. Terpene polychlorinates (chlorinated mix- O,O-Diethyl O-(2-diethylamino-6-methyl-4- ture of camphene, pinene, and related pyrimidinyl) phosphorothioate and its oxy- terpenes 65-66 percent chlorine). gen analog diethyl 2-diethylamino-6-meth- 2,3,5,6-Tetrachloronitrobenzene. yl-4-pyrimidinyl phosphate. (2,4,5,4′-tetrachlorodiphenyl O,O-Diethyl O-(2-isoprophyl-4-methyl-6- sulfone). pyrimidinyl) phosphorothioate. Toxaphene (chlorinated camphene). O,O-Diethyl O-[p-(methylsulfinyl)phenyl] Trichlorobenzoic acid. phosphorothioate and its cholinesterase-in- Trichlorobenzyl chloride. hibiting metabolites. Diethyl 2-pyrazinyl phosphate. (5) The following are members of the O,O-Diethyl O-2-pyrazinyl phosphorothioate. class of cholinesterase-inhibiting pes- S-(O,O-Diisopropyl phosphorodithioate) of N- ticides: (2-mercaptoethyl) benzenesulfonamide S-(O,O-Diisopropyl phosphorodithioate) of N- Acephate (O,S-dimethyl acetyl- (2-mercaptoethyl) benzenesulfonamide phosphoramidothioate) and its cholin- 2-(Dimethylamino)-5.6-dimethyl-4- esterase-inhibiting metabolite O,S-di- pyrimidinyl dimethylcarbamate and its methyl phosphoramidothioate. metabolites 5,6-dimethyl-2- (2-methyl-2-(methylthio) (formylmethylamino)-4-pyrimidinyl propionaldehyde O- dimethylcarbamate and 5,6-dimethyl-2- (methylcarbamoyl)) and its (methylamino)-4-pyrimidinyl chlorinesterase-inhibiting metabolites 2- dimethylcarbamate (both calculated as methyl-2-(methylsulfinyl)propionaldehyde parent). O-(methycarbamoyl) oxime and 2-methyl- 2-(methylsulfonyl)propionaldehyde O- (O,O-dimethyl S-(N-methyl- (methylcarbamoyl)oxime. carbamoylmethyl) phosphorodithioate). 4-tert-Butyl-2-chlorophenyl methyl methyl Dimethoate oxygen analog (O,O-dimethyl S- phosphoramidate. (N-methylcarbamoylmethyl) S-[(tert-Butylthio)methyl] O,O-diethyl phosphorothioate). phosphorodithioate and its cholinesterase- O,O-Dimethyl O-p-(dimethylsulfamoyl) inhibiting metabolites. phenyl phosphate. (1-naphthyl N-methylcarbamate). O,O-Dimethyl O-p-(dimethylsulfamoyl) (2,3,-dihydro-2,2-dimethyl-7- phenyl phosphorothioate. benzofuranyl-N-methylcarbamate). 3,5-Dimethyl-4-(methylthio) phenyl Carbofuran metabolite (2,3-dihydro-2,2-di- methylcarbamate. methyl-3-hydroxy-7-benofuranyl N- O,O-Dimethyl S-[4-oxo-1,2,3-benzotriazin-3- methylcarbamate). (4H)-ylmethyl] phosphorodithioate. (S-[(p-chlorophenyl) Dimethyl phosphate of 3-hydroxy-N,N-di- thiolmethyl] O,O-diethyl methyl-cis-crotonamide. phosphorodithioate) and its cholinesterase- Dimethyl phosphate of 3-hydroxy-N-methyl- inhibiting metabolites. cis-crotonamide. Chlorpyrifos (O,O-diethyl O-(3,5,6-trichloro- Dimethyl phosphate of a-methylbenzyl 3-hy- 2-pyridyl)phosphorothioate). droxy-cis-crotonate. Chlorpyrifos-methyl (O,O-dimethyl-O-(3,5,6- O,O-Dimethyl 2,2,2-trichloro-1-hydroxyethyl trichloro-2-pyridyl) phosphorothioate. phosphonate.

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O,O-Dimethyl phosphorodithioate, S- O,O,O′,O′-Tetramethyl O,O′-sulfinyldi-p- with 4-(mercaptomethyl)-2-methozy-D2- phenylene phosphorothioate. 1,3,4-thiadiazolin-5-one. O,O,O′,O′-Tetramethyl O,O′-thiodi-p-phen- (2,3-p-dioxanedithiol S,S-bis (O,O- ylene phosphorothioate. diethylphosphorodithioate)) containing ap- Tributyl phosphorotritlioite. proximately 70 percent cis and trans iso- S,S,S-Tributyl phosphorothrithioate. mers and approximately 30 percent related 3,4,5-Trimethylphenyl methylcarbamate and compounds. its 2,3,5-trimethylphenyl EPN. methylcarbamate. Ethephon ((2- - chloroethyl) phosphonic acid). (6) The following pesticides are mem- . bers of the class of dinitrophenols: Ethion oxygen analog (S- 2,4-Dinitro-6-octylphenyl crotonate and 2,6- [[(diethoxyphosphinothioyl)thio] methyl] dinitro-4-octylphenyl crotonate, mixture O,O-diethyl phosphorothioate). of. O- Ethyl O-[4-(methylthio) phenyl] S-propyl 4,6-Dinitro-o-cresol and its sodium salt. phosphorodithioate and its cholinesterase- Dinoseb (2-sec-butyl-4,6-dinitrophenol) and inhibiting metabolites. its alkanolamine, ammonium, and sodium O-Ethyl S,S-dipropylphosphorodithioate. . Ethyl 3-methyl-4-(methylthio)phenyl (1- methylethyl) phosphoramidate and its cho- [41 FR 8969, Mar. 2, 1976] linesterase-inhibiting metabolites. EDITORIAL NOTE: For FEDERAL REGISTER ci- O-Ethyl S-phenyl ethylphosphonodithioate. tations affecting § 180.3, see the List of CFR O-Ethyl S-phenyl ethylphosphonothiolate. Sections Affected, which appears in the m-(1-Ethylpropyl)phenyl methylcarbamate. Finding Aids section of the printed volume S-[2-Ethylsulfinyl)ethyl] O,O-dimethyl and at www.fdsys.gov. phosphorothioate and its cholinesterase-in- hibiting metabolites, (primarily S-[2- § 180.4 Exceptions. (ethyl-sulfonyl)ethyl] O,O-dimethyl phosphorothioate). The substances listed in this section (O,O-dimethyl O-[3-methyl-4- are excepted from the definitions of (methylthio)phenyl]phosphorothioate and ‘‘pesticide chemical’’ and ‘‘pesticide its cholinesterase-inhibiting metabolites. chemical residue’’ under FFDCA sec- . tion 201(q)(3) and are therefore exempt N-(Mercaptomethyl)phthalimide S-(O,O-di- from regulation under FFDCA section methyl phosphorodithioate). 402(a)(2)(B) and 408. These substances N-(Mercaptomethyl)phthalimide S-(O,O-di- methyl phosphorothioate). are subject to regulation by the Food Methomyl (S-methyl N- and Drug Administration as food addi- [(methylcarbamoyl)oxy]thioacetimidate). tives under FFDCA section 409. 1-Methoxycarbonyl-1-propen-2-yl dimethyl (a) Inert ingredients in food pack- phosphate and its beta isomer. aging treated with a pesticide, when m-(1-Methylbutyl)phenyl methylcarbamate. such inert ingredients are the compo- Methyl . nents of the material (1,2-dibromo-2,2-dichloroethyl di- (e.g. paper and paperboard, coatings, methyl phosphate). adhesives, and polymers). (methyl N′,N′-dimethyl-N- [(methylcarbamoyl)oxy]-1- (b) [Reserved] thiooxamimidate) [63 FR 10720, Mar. 4, 1998, as amended at 73 Parathion. FR 54976, Sept. 24, 2008] (O,O-diethyl S-(ethylthio)methyl phosphorodithioate) and its cholinesterase- § 180.5 Zero tolerances. inhibiting metabolites. (S-(6-chloro-3-mercaptomethyl)-2- A zero tolerance means that no benzoxazolinone) O,O-diethyl amount of the pesticide chemical may phosphorodithioate). remain on the raw agricultural com- (2-chloro-2-diethylcarbamoyl- modity when it is offered for shipment. 1-methylvinyl dimethyl phosphate) includ- A zero tolerance for a pesticide chem- ing all of its related cholinesterase-inhib- ical in or on a raw agricultural com- iting compounds. modity may be established because, Pirimiphos-methyl O-[2-diethylamino-6- among other reasons: methyl-pyrimidinyl) O,O-dimethyl phosphorothioate (a) A safe level of the pesticide chem- Ronnel. ical in the diet of two different species (octamethylpyrophosphoramide). of warm-blooded animals has not been Tetraethyl . reliably determined.

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