The Newsletter of the NIH Alumni Association

Spring 1999 Vol. 11 , No. 1 date Lively Debate Warms Award, Meeting, Lecture ACD Meeting Morella, Henney, Choppin Slated for NIHAA Events

By Ricli McMa1111s In 1999. the NIH A lumni Association commissioner, ..-i ill be the featured will host two important events. rirst, speaker. Then in th e fall, Dr. Purnell Last December's meeting of the Rep. Constance W. Choppin. advisory commiuee to the NIH A. Morella (R­ president of the director was a 101 like th e unusual M d.) will be Howard Hughes weather the week ii was conducted-a honored with M edical Instirute, tad holler than anyone expected. the 1999 will deliver the third While it included. early in 1he agenda. NIHAA Public James A. Shannon a winning synopsis of progress in the Service Award Lecture on Wednes­ Human Genome Proj ect delivered by at the NIHAA day, Nov. 17. at 3 N HGRI director Dr. Francis Collins. annual meeting p.m. in M asur who reviewed the ambitious scope of that will be held Auditorium. the institute's new 5-year plan. the on June 12. In Rep. Morella was next two topics-plans for an "NLH addition. Dr. reelected in 1998 to Academy:· including a degree-granting Jane E. Henney. graduate school. and a revisiting of the new FDA Rep. Constance A. Morella (R·Md.) (see Even1s. p. 2) last summer's Institute of Medicine report on priority-setting at N lH­ provoked passions around the table. Generous '99 Budget; Small 2000 Projection Deliberations were further enlivened Dec. 3 by the presence of special By Rich McMa1111s Enacted in Public Law I05-277. the invitees including Katherine Graham. budget also brings new entities and chair of the Wc1slii11gto11 Post executive While there have been larger percent­ names to the campus., including new commiuee. age increases in NJ H's budget in (See Budgets, p. 14) The meeting al ways starts with a decades past- mostly during 1he State of the N IH overview by th e Shannon era in the early sixties, when director. which ranges from personnel new institutes began prolifera 1.ing-1hc In This Issue Pagt' announcements to from-burner policy $2.03 billion addition to the FY I998 Re.f£•mr:h Fes1iw1l '98 3 issues; Dr. Harold Yarmus cautioned at level signed by President Clinton on the outset lhat there were "quite a few Oct. 2 1 is by far the largest dollar Calendnr 4 diverse and controversial topics" on increase in agency history. The 14.9 News from and abo111 NIHAA members 5 the agenda. Having testi lied the day percent bump-up brings the FY 1999 beforl! at a Senate hearing on research appropriation Lo $15 .652 billion. a RM£•11herg delfrers Shan11011 lec111re /0 involving embryonic stem cells, figure hailed jubilantly in all corners Science Research Updntes 16 Varmus lirst had to endure some good­ of the agency. natured ribbing from colleagues who "This degree of confidence in N IH R& W 1imeli111! 18 had seen news coverage describing the by the Congress. the administration '·eloquence" of the testimony at the and the American people brings with it Framingham s1111{1• annfrersary 19 hearing. a special responsibility to continue the FYI 20 Among highlights from 1he year-in­ high quality research traditions at N IH review was news th at Varmus is laboratories and among our grantees. Nill Noles 22 "negotiating with what I hope will be and to ensure the highest quality of [\/ail-ill bn/101 f(Jr board 29 the final candidate" to head the new adminisrration of these funds.'' said j Vaccine Research Center at N IH. Tony ltteilag, NLH deputy director for Nil1 Re1msper1il•es 31 (See Meeting p. 12) management. N I H A A U P D A T E

Events ( comin11ed from p. I ) a seve111h term for the 8th Congres­ first woman to b~ appointed as FDA Update sional district. an area that includes commjssioner. Henney was deputy Tile 'lliAA Update is the newsleuer oftile the NIH campus. director of NCI ( and aJso 1980-1985) NIH Alumni Association. The NIHAA office Her selection as this year·s awardee a medical oncologist at the institute is at 9101 Old Georgetown Rd.. Bethesda. was based on her continuing, compre­ ( 1975-1985). She was the deputy MD 20814-1616. 301-530-0567. hensive and strong support for NIH commissioner for operations ( I 992­ and her prompt and unfailing respon­ 1994) under former FDA commis­ Editor's Note siveness to contacts on behalf or the sioner, Dr. David Kessler. The Nll-IAA Update welcomes leuers a11d institution. Maintainjng her well­ Henney left that position 10 become 11ell'S from its readers. \Ve wish to /Jro1•ide established reputation for independent vice presidenc of the University of New 11ell's abom NIH to its alumni and to thought and action as a member of Mexko Health Sciences Center. where report tilumni concems and i11formmio11­ Congress. her support for NIH is she supervised the medical school. the appoi111mems. honors. publicmions a11d tempered by her sense of public college of phannacy and several other i111eresti11g de1·elopmems-to their colleagues. If you hm•e news a bow yourself responsibility in probing for the teaching hospitals. or other alumni or commemslsuggestio11s justification and authenticity of any The NIHAA annual meeting will forthe NIl-I AA Update. please drop t11101e to request for assistance. also include a short business meeting the editor. We resen·e the right to et/ii Further, her committee assignments and an announcement of new officers m(lferials. on Governmem Reform and Oversight and newly elected members of the Editor: Harriet R. Greenwald and on Science have provided a basis board. for deep understanding of the role of Details about the Shannon lecture NIHAA Newsletter Editorial Advisory a federal agency in the nation's will be in the summer issue of the Committee cientilic aspirations and policies. NIHAA Update. As part of the annuaJ meeting Invitations to both events will be Jerome G. Green. Chaimwn Ar1rice B"der program. NfHAA members will meet mailed to members in the spring Michael M. Gouesman and hear from Dr. Jane Henney. the and faJl . Victoria A. Harden C"rl l..e11emlwl Robert G. Martin Abner Louis Notki11s Two Upcoming NIHAA Events Saul Rosen Storm Whaley Richard G. \Vyau

NIHAA News/el/er Board of Contributing Editors

A1111ual Meeting and Pamela E. Anderson Public Service Award James A. Sha11110T1 Lecture Wednesday, Nov. 17, I 999 Unda Brown Saturday, June 12 Giorgio Bernardi 3 10 a.m. - noon p.m. H. Franklin Bunn The Mary Woodard Lasker Center Masur Auditorium Henryk J!ise11ber11 Bldg. 10 Donald S. Fredrickson (Bldg. 60) 0 11 the NIH Campus u1rs A. Ha11so11 Reception Following George Klein Light Refreshments Richard M. Kmuse Robert Q. Marston Richard McMa1111s Carlos Monge Roger Monier Seymour Perry Lois A. Sa/::.J11a11 Michael Sela

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NIHAA Officers Research Festival '98 a Big Draw William S. Jordan, Jr., President William I. Gay, Vice President It was as if some giant had grabbed But that sentiment, combined with Jerome G. Green. Vice Presidell/ the NIH campus by the corner up near leaden skies for two of the fes tival's Storm Whaley, Secre/(/ryffreasurer the firehouse on Old Georgetown Rd. three days, did nothing to dampen the Past Presidents and Lilted it so that everything slid enthusiasm of attendees. one of whom, helplessly toward the Natcher Bldg. NIH director Dr. Harold Varmus. Calvin 8. Baldwin. Jr.. President 1995-1997 Oct. 6-9 as the 12th Research Festival exited the apoptosis session beaming Thomas J. Kem1ed11, Jr. . drew many hundreds of NlH'ers to a and waving, invigorated, not President 1993-i 995 ravishing feast of intramural science. bedimmed, by his encounter with the Joe R. Held. Preside/I/ 1991- 1993 For 3 days, Natcher and its environs biological enforcers of cells' demise. Gordon D. Wallace. Presidem 1990- 1991 were to science what Bethesda is to Teetering, perhaps unironically. Board of Directors restaurants-a teemiJ1g smorgasbord of between the opening session on life's Carl C. Baker tas ty possibilities. cosmic origins and the final. apoptotic W. Emmel/ Barkley It became almost comical, after a day (if not apocalyptic) session, was \Vil/iam R. Carroll or two. to see hundreds of pre-, post­ " Insight from the Bedside,'' which Belia l. Ceja and postpostclocs fleeing the crowded offered hope for the still-living, Peter Condl(ffe John L Decker morning plenary sessions for one of including insights into AIDS pathogen­ Murray Eden dozens of workshops held in various esis and description of a new vaccine Carl Fre11s nooks and warrens within the sprawl­ 10 prevent severe diarrhea in infants Murra\' Goldstein ing Natcher complex. aml youngstt:rs. Samuel W. Greenhouse All adopted postures of predicament Por those addled by the possibilities. Mary Calley Hartman Joe R. Held as they scanned the glossy 83-page there were massive tents outside the Joseph Keyes, Jr. menu of choices. brows knit in Natcher center offering diversions of a Lloyd W. UM concentration. What if, by chance, sort: on the southeast side were two Teny l. Lierman you were interested in both "Charac­ tents housing the Technical Sales Lois F. Lipsett terization of Biologic Mediators by Association's annual exhibit of Walter Magruder Carolyn McHale Spectroscopic M ethods" and "Gene scientific equipment, and to the Charles Miller. II Regulatory Proteins," both lighting for northwest sat a picnic tent, including a Paul D. Parkman your attention from 10:30 a.m. LO half stage where some intramural perform­ Joseph Perpich past noon on the festivar s last day? ers entertained. Paul Q. Peterson The lead topics themselves could The TSA tents were a swarming Stud Schepa rt::. Randy Schools produce anxiety. The plenary session-; bazaar of scientific supplies presented Mary R. Sea rs kicked off Wednesday. Oct. 6 with by a slew of manufacturers, each Harley Sheffield speculations on cosmology and the offering such freebies as dishes l'ull of Jo/Jn F. Sherman origins of life. introduced by NASA hard candy. pens. coffee. mousepads. Lawrence £. Shulman Administrator Daniel Goldin. drink cups, and rame chances 0 11 items J. Craig Verrter Bern/Jard Witkop The final plenary session Friday was ranging from cell phones to Polartec on apoptosis-programmed cell fleece outerwear. Almost everyone NIHAA Staff death-and included detailed descrip­ trekking back to their labs on campus Harriet R. Cree11wald tion of molecular "death domains.'' after a trip to Research Festival bore a Mary Calley Har1111a11 Concluding a discussion of ALPS­ plastic shopping bag sn.1ffed with 1'11E NIH Al.UMNI A SSOCIATION T HANKS autoimmune lymphoprolif'erative giveaways. W vf:m·A YEttST R £Sf;ARCll OP AMF.RI CA syndrome-NlA lD's Dr. Stephen Organizers called the 12th festival a H o~lf: P ROl)UCTS AN» M F: R<.:K & Co., I c. Straus quoted Ecclesiastes: "For success and are already critiquing their f'OR T lllml 111\1.1' IN UNDERWRITING TllE everything there is a season, and a effort s in preparation for lucky 13, a 3- l'UUl.ISlllN(; 01' Tllll Nl/1AA Ul'IJAT!i, ANll \Vl' E.XTEN» At•1•1u·:C1ATtON TO NlHAA MEMnrms time for every mauer under heaven: a day swath in Ocrobcr 1999. WHO CONTRllllff'E DONATIONS llF.YOND T llElll time to be born, and a time to die.'' - Rich McManus OUf'.S l'A YMEl\'T.

3 N I H A A UPDATE

Calendar of Upcoming Exhibits and Events Exhibits be held in Frederick. Md. Events of interest to both scientists and the National Library of Medicine general public are planned from 11 a.m. to 5 p.m. each day. For infonnation A National Library of Medicine contact Dr. Howard Young at exhibit enLitled. ···That Girl There is [email protected]. Doctor in Medicine·: Elizabeth Blackwell. America's First Woman USPHS Luncheon MD.:· is on view until June 30, 1999 at the entrance just off the NLM lobby On Thursday. May 6. Lhe annual (Bldg. 38. 8600 Rockville Pike). reception/luncheon for the U.S. Public The exhibiL curated by Carol Clausen Health Service retirees will be held at of NLM's History of Medicine Divi­ the Officer"s Club of the Naval Medical sion. contains items illustrating Hospital in Betllesda. The reception. Blackwell's admission to medical with an open bar. will begin at 11 a.m. school, her experiences as a medical Lunch will be served at 12:30 p.m. student. her graduation and her subse­ Cost of Lhe luncheon is S 15. Reserva­ quent medical career. For more tion wilh check should be sent Peter J. information call 301-435-4993. Bersano, 6043 No. 5th Rd., Arlington. VA 22203- L054. Deadline is Apr. 25. Another exhibit. ··Breath of Life"' Dr. Elizabeth Blackwell at age 38 in a drawing that examines the history of asthma. by Comtesse de Chamacee. NIHAA Events the experiences of people with asthma and contemporary efforts to under­ 301 -594-5595. Following is a sample The Annual Meeting and Public stand the disease is on view in the of events in the series: Service Award will be held on NLM Rotunda until June 30, 2000. Saturday, June 12 at the Mary This show celebrates Lhe tenth anniver­ April 28-Rollo E. Dyer Lecture - Woodard Lasker Center (the Cloister). sary of the National Asthma Education Dr. Charles Dinarello - "Anti-Cytokine Bldg. 60, 10 a.m.-noon. on the grounds and Prevention Program. For more Therapies for Inflammatory Diseases.'' of the NIH campus. Invitations with information. call 301 -594-7170. May S-Robert S. Gordon, J r. details will be mailed to NIHAA Lechir e-Dr. Walter WilJen - "' Diet members in May. DeWitt Stetten, J r., Museum and Coronary Heart Disease: Have we misled the Nation?" Coming Up in the Fall For up-to-date infom1ation about J une 9, 2-4 p.m.-General Motors exhibits around the campus mounted by Cancer Research Foundation Annual Research Festival '99 Lhe DeWitt Stetten. Jr., Museum of Scientific Conference - Introduction by Oct. 5-8 - Job Fair, Symposia. Medical Research. contact the NIH Dr. Samuel A. Wells. Jr. Laureates Posters. Workshops. Technical Sales Historical Office at 301-496-6610. lectures by winners of General Motors Association Scientific Equipment Prizes for Cancer Research. Show-All in or about Lhe William H. NIH Events Natcher Conference Center. Fred erick Event The NrH Director's Wednesday The third James A. Shannon Lecture Afternoon Lectures are held at 3 p.m. On Thursday. May 13 and Friday. will be delivered by Dr. Purnell W. in Masur Auditorium, Bldg. 10. For May 14, the third annual Fort Detrick­ Choppin on Wednesday. Nov. 11. at 3 more info1mation about the spring FCRoC Spring Research Festival wi ll p.m. in Masur Auditorium. Bldg. JO. schedule call Hilda Madine at For more information about ~ e\enl'> call 301-.i96-1767. For more in formation about NillAA events call 301-530-0567.

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News From and About NIHAA Members

Dr. John J. Bartko, statistician, who Dr. Edward N. Brandt, Jr., who was Vincent Cairoli, who, after 22 years of served NIMH (1962- 1995) as a assistant secretary of heallh (1981- federal service, retired as chief of the commjssioned oificer in d1e PHS, has 1984), is now Regents professor and Cancer Training Branch at NCI, was been a professor of statistics at the di rector of the Center for Health Policy honored by the American Association Maryland Psychiatric Resea(cb Center, Research and Devel.opmenl at the for Cancer Education at itS annual School of Medicine, University of University of Oklahoma. He writes. ''I meeting last November in Portland, Maryland since his retirement in 1995. have been awarded the honor of being Ore. He received recognition for He ·wri tes that he "conlinues his nru11ed lhe National Scholar of the "many years of dedicated service on research in statistical methods, reliabil­ triennium 1998-200 I by the Phi Kappa behalf of cancer education activities in ity and multivariate analysis with data Phi National Academic Honor Society. the U.S." He is now living in Ft. from patients suffering from schizo­ 1 have also served on the advisory Lauderdale. phrenia." He also serves as a private committee of the Office of Research on consultant. Women's Health."

Dr. Robert L. Berger, who retired from NRLBl after 34 years of service, was the recent recipient of the 1998 Eberly College of Science Alumni Society Distinguished Service Award, the society's highest honor. IL recog­ nizes i11dividuals who have made exceptional service and leadership contributions to Penn State University or its alumni society. He has worked to increase the visibility of the university and Ebedy College by helping students from the college acquire cooperative educatio11 positions ac NHLBI and the Walter Reed Army Institute of Re­ ··~ search. Berger volunteers at Walter Reed, where he continues his instru­ ment development and hemoglobin research.

Dr. Baruch S. Blumberg, a 1976 At a well-attended meeting on Friday, Nov. 13, 1998, Dr. Ruth L. Kirschstein , NIH deputy Nobel laureate who was in the director, presents to Dr. Robert N. Butler, first director of the National Institute on Aging , the geographic medicine and genetics 1998 NIHAA Public Service Award, an etched desk plaque depicting the Shannon building. sections ofNIAID ( 1957- 1974), is The accompanying citation states in part, "In recognition of: his leadership in the establish­ now a Distinguished Scientist at Fox ment of geriatrics as a recognized academic discipline, his ability to educate the public and Chase Cancer Center. He recently their political representatives about the nature of the aging process and the opportunities received the John Scott Award for for prolonging independent living in later years, and his broadening of the array of outstanding conn·ibutions to lhe disciplines contributing to advances in the field of gerontology. " In accepting the award, advancement of science and medicine. Butler told of his continuing activities related to the significance of aging in the realms of The award includes a medal, and a medicine and society. He spoke with warmth of his affection and respect for NIH and of his optimism for its future. $10,000 prize is given by the Philadel­ phia Board of Directors of City Trusts.

5 N I H A A UPDATE

Dr. Deborah J. Cotton, who was at meeting in Acapulco, Mexico. She was Dr. Vay Liang W. Go, who was with NfH (1978-1984), is now assistanl recognized for her contribucions to the NIDDK as direcror of the Division of provos1 and director of Office of profession and to society and the Digestive Diseases and Nutrition Clinical Research, Boston Universi1y, ongoing impact of lhese contributions ( 1985-1988). is now at the Center for Medical Campus; professor of medi­ to the provision of health care services Human Nuuition, University of cine, Boslon University School of in lhe U.S. and in all regions of the California. Los Angeles. He was one of Medicine; and professor of epidemiol­ world. three senior editors of the second ogy and biological statistics, Bos1on edition of Nurri1ional Oncology. University School of Public Health. Dr. Robert Gano, who was at NCI for She is also the editor of AJDS Cli11ical over 30 years, is now director of l:be D1~ Hcskel M. Haddad, who was at Care, a monthly newsletter on lhe latest University of Maryland's Inslitute of NHLBI (1958-1960) as a clinical developments in the diagnosis and Human Virology in Baltimore. He associate, writes that he "chaired a treatment of HIV-related diseases. presented a personal perspective on symposium on metabolic cataracts at HIV /AIDS research at NlAID's 50th lhe International Congress of Ophthal­ Dr. Raphael ''Ray" Dolin, who was a1 anniversary scientific symposium held mology in Amsterdam. Holland, June NlAJD ( 1974-1978) in various posi­ last Nov. 19. 28, l 998. and presented ·Diet Manage­ tions, was appointed faculty dean for ment of Metabolic Cataracts.'" clinical programs by Harnu·d Medical School in September. He was the chair of medicine at tbe Uni versity of Rochester and physician-in-chief at Strong Memorial Hospital. He has had extensive research and clinical experi­ ence working with gastrointestinal. influenza and herpes viruses.

Dr. R. Gordon Doug.las, Jr., who was a clinical associate and clinical investi­ gator at NIAID in the Laboratory of Clinical Investigation, ( 1963-J 966), is now president of Merck Vaccines. I-le participated in NIAID's 50th anniver­ sary celebration held last Nov. 19. The overall lheme of the scientific sympo­ sium was ·'Advancing Knowledge and lmproving HeaJth.'' Douglas spoke on "The Future of Vaccines: Science. Public Health and Medicine."

Vernice Ferguson was chief of the nursing department at d1e CC ( 1973- Dr. Jane E. Henney (r) stands next to Dr. Edward N. Brandt, Jr. , (I) at the reception 1980) and then became director of following her being sworn in as FDA commissioner by Vice President Al Gore on Dec. 15. nursing at the VA and assistant chief Henney said she was "committed to assuring that the FDA was a science-based public medical director in 1992. She then service organization." She is the first woman to serve as FDA commissioner and is an went to work al the School of Nursing, alumna of NIH (1975-1985), serving in the NCI as an oncologist and as deputy director. University of Pennsylvania. Recently On June 12, she will be the speaker at NIHAA's annual meeting . she was one of three "Living Legends" and exemplary role models honored by Lhe American Academy of Nursing at a

6

N I H A A UPDATE

Dr. Paul J. Schmidt, who was chief of Or. Sheldon L. Spector, who was Dr. James H. Steele, who with Dr. the CC Blood Bank (now the u·ansfu­ research investigator in the Laboratory Charles Armstrong worked on brucello­ sion medicine department) from 1954 of Virology and Rickettsiology ( 1966- sis and infectious diseases (1945- 1947) to 1974, reports that he ·'recently 1968), DBS, writes from Los Angeles at NIH. is professor emeritus at the opened the First Gulf Cooperative that he "recently assumed the position University of Texas School of Public Countries Blood Transfusion Confer­ as president of the California Allergy Health. Recently he was honored by ence in Abu Dhabi (the largest sheik­ Society." He is former chainnan of the the Harvard School of Public Health (he dom) in the United Arab Emirates. task force for practice parameters, and received an M.P.H '43) with the A lumni This was a first conference intended for continues to hold an active position on Award of Merit. He has been called unifying transfusion medicine in the the task force. He is also involved " lhe founding father of public health Gulf States: Saudi Arabia. Kuwait, in writing guidelines for allergy and veterinary science." His 60-year career Qatar. Oman, Bahrain and the Emir­ immunology. As director of the Allergy has been marked by several firsts: He ates." At the conference. he made a Research Foundation. he continues to started the first U.S. veterinary public presentation on proposed international do clinical research in the field of health program. He also initiated the cooperative standards for blood asthma. allergy and skin diseases. He first formal rabies control progmm in collection and transfusion, based on the can be contacted at 3 10-312-5050. the US and a variety of other programs. U.S. model. Schmjdt is professor of fax: 310-828-9673. He was active in international veteri­ pathology at the University of South nary public health programs. Floridu and a former president of the American Association of Blood Banks. ne Aminco-Bo.Nman >pectrophoto~uorometei lhe lrwento and theChnllenq "SPf'

,_./ Two and a half years after his death, Dr. Robert L. Bowman, former chief of the NHLBI Laboratory of Technical Development and an NIHAA member, was honored for his influential invention, the Aminco-Bowman spectrophotolluorometer (SPF) that popularized UV visible fluorometry. A day-long symposium focused on how the SPF was invented and the instrument's modern research legacy that has led to innumerable contributions in protein and DNA research. Attending the ribbon-cutting ceremony on June 19, 1998, for the Aminco­ Bowman Spectrophotofluorometer exhibit outside Lipsett Amphitheater in Bldg. 10 are (from I) Alice Bowman, widow of Dr. Robert L. Bowman; Dr. Robert Berliner, former NIH deputy director fo r science; Dr. Edward Korn, director of the NHLBI Divisi on of Intramural Research; Dr. John Watson , NHLBI deputy director; Dr. Victoria Harden, NIH historian and director of the DeWitt Sletten, Jr. Museum of Medical Research , and Dr. Jay Knutson and Dr. Robert Berger (retired), NHLBI scientists and two of the event coordinators.

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Dr. Craig L. TendJer, who was with Dr. Myron Winick, who was a visiting the NCI Metabolism Branch (1988- scientist at NCI (L987-1990), reports What's Your News? 1991) writes "I am currently the that he is now the medical director of Director of Oncology Research Weight Watchers International. and The NIHAA wants to hear from its mem- at the Schering-Plough Research recently received an award from the hers. Please type or print your note lnstitute, responsible for the worldwide Society of Nutrition Oncology (include photographs, if you have them) development of novel agents for the Adjuvant Therapy for research on and ma il it to Update at 9101 Old Georgetown Rd., Bethesda, Md. treatment of breast cancer. We have nutrition and cancer. just hired two NIH alumni to work in 20814-1616. our group: Sara Zaknoen and Scott Dr. James B. Wyngaarden, former Freeman. Sara is a medical oncologist NIH director (1982-1989), has been who completed her NCI fellowship in named chairman of a scientific advisory Name: 1992, and Scott is a pathologist who counciJ that wiU oversee a 12 million played a key role in the first gene dollar program funded by the Doris Home Phone: therapy program at NIH in the eady Duke Charitable Foundation. The 1990's. Both Sara and Scott, with their foundation has established a Distin­ expe11ise in clinical research trials and guished Clinical Scientist Award News: (Include NIH affiliation) gene therapy protocols, respectively, are Program to fund the research teams of already making major contributions to four leading scientists studying cancer our oncology research division." and other diseases. Senior clinical scientists at the 25 medical schools Dr. Bruce Waller, who was at NHLBT receiving the greatest an1ount of ( 1978-1982) is with Nasser. Smith and support from NIH may apply. The Pinkerton Cardiology Inc., in India­ award recipients will be named in napolis. They merged with Northside late 1999. Cardiology and Storer Schmidt & Associates, effective Jan. I , 1999. This Dr. John L. Ziegler, formerly NCI merger forms The Care Group, LLC, to branch chief (Pediatric Oncology) be one of the largest non-academic and associate director (Clinical Oncol­ cardiology practices in the U.S., with a ogy) ( 1966-1981) and editor-in-chief total of 32 cardiology and primary care of the Journal of rhe National Cancer offices throughout Indiana. The group /11stitute, writes: "T have been at UCSF wi ll have 87 cardiologists and 52 since leaving NCI, although l spent 6 primary care physicians. years abroad (3 in Uganda and 3 in the U.K.) in the 1990's. Now back at Dr. Gary Williams, at NCI in the UCSF at the Cancer Center's Cancer Etiology Division ( 1969- 1971) and Risk Program. purting my new M.Sc. now director of the Naylor-Dana in epidemiology (Univ. of London) to Institute, American Health Foundati,on, good use. I can be reached at email: Valhalla, N.Y., has forwarded informa­ Ziegler@i tsa. ucsf.ed u. " tion about the 7th [ntemalional Course on the Safety Assessment of Medicines. The course will be held May 16-21 , Continuing Education, Inc., l 999 in San Francisco. Please comact University at Sea is sponsoring, in Ms. Nancy Rivera at the American conjunction with Holl and America, Health F'oundation. I Dana Road, a series of medical meetings. Valhalla, N.Y. I 0595-1599: telephone: Interested NIHAA members, please 914-789-7144; fax: 9 14-592-6317; call 800-926-3775 or email: email: [email protected]. [email protected]

9 N I H A A UPDATE

Rosenberg Decries Decline of Physician/Scientist

By Rich McMcmus toxic to spawning young [M.D.] haven. "He was an ideal mentor for investigators," be argued. "The me. He was nurtur.ing, ti reless, When Dr. Leon Rosenberg came to swdents hear nothing but how hard it inventive." Rosenberg said the "sense Nill in 1959 to begin a 6-year stint at is to gel research money and the time of well-being and exuberance were so the National Cancer fo stitute's to do research." intense" following his first NlH metabolism service, he was a newly Rosenberg admitted that his own experiment that he made a life long minted M.D. who was aniving al U1e start as a young doc at NIH, even in a commjtment to clinical research, a Mecca of his profession: a burgeoning halcyon era, was bumpy. "Things marriage that lasted through a variety pinnacle of bi.omedical research began badly," he confided. '·1 didn' t of administrative and academic pol;tS crafted largely by the influence of U1en gel along with my supervisor. l rudn't at Yale University (where he was dean NIB director Dr. James A. Shannon, a want to work on the project to wluch I of the medical school) and at Bristol­ physician/scientist whose "intelli­ was assigned." Myers Squibb, where he has been gence. vision ... and poli tical He was rescued by Dr. Nathanjel president of the Pharmaceutical acumen ... produced a powerful magne­ Berlin, who gave him the time and Research InsLitute and senior vice ti sm" that attracted Rosenberg, and freedom to get his bearings-a period president of scientific affairs. "My many others among the best and lasting almost a year. During that research lab has al ways been my port bri ghtest in medicine in that era, to NLH. ''We were all eager to prove we had Lhe right stuff,'' he recalls. Clinical research at NLH was the thing lo do for an am bi tious young physician in those days. reflected Rosenberg, who deUvered the second Shannon Lecture, sponsored by the NrH Alumnj Association and NIH's Office of the Director, on Oct. 26 in Masur Audjrorium. He wem on to lament. "Why is it so clearl y not the thing lo do today?" Rosenberg, now a professor of molecular biology at Princeton, lecturer in the university's Woodrow Wilson School of Public and Intern a­ tional Affairs, and president and chief Dr. Leon Rosenberg (c), who gave the second annual James A. Shannon Lecture, is executive oflicer of Funding First. flanked by hosts Dr. William Jordan (I), president of the NIH Alumni Association, and bui lt a carefully documented analysis NIDDK's Dr. Alan Schechter. Jordan drew laughs when he observed , in introductory remarks about Shannon , that "Bldg. 1 (the Shannon Bldg .), as far as I can tell, is the only of the demise of the M.D. who also building on campus named after a scientist." does research: whereas this creature once predominated, he now finds time, Rosenberg became responsible in the storm, my sturdy anchor. I himself extinguished by a variety of for U1e care of an 8-year-old patient always thought of myself as a clinical factors including powerful messages named SLeven, a boy who died 2 invesligator, though some would have From the public about the M.D.'s social years later, just as his older brothers desclibed me as a basic scientist. I (versus intellectual) responsibi Ii ties. had, due to an inborn metabolic error. didn 't care how il was qualified, as economic disincentives. inadequate "T read up on medical genetics and long as it involved doing the best postdoctoral training, unstable NIB amino acid metabo lism," Rosenberg possible research." funding, and Lhe expiosive growth of recalled, and an NIAMD investigator The Shannon legacy from which managed care. These factors "are named Stanton Segal gave him a Rosenberg benefirted so greatly-'·the

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accomplishments of the Shannon years interest in a L989 survey, 10 percent in national database to track the restora­ were so prodigious they cannot be 1996). "The human pipeLine is tion of the species. overstated," he declared-is now emptying at the worst possible spot," "NIH training programs have not imperiled, he argued. It was during Rosenberg observed. grown apace with budget increases," Shannon's l3-year directorship that Does it matter if the species evapo­ he charged. "It's time they did." "the proverbial brjdge between the rates? Rosenberg predicts that the NIH can't rectify the problem alone. [laboratory] bench and bedside was built and buttressed," but that edifice is i11 danger, Rosenberg warned. "Are we doing enough to sustain and strengthen the medical rese

11 N I H A A UPDATE

Meeting (co11 ri11ued from p. I) ··with unbelievable admiration" at the half of the human genome. and work of the Human Embryo Research ·'achieving coverage of at least 90 ''The new YRC building is on a Panel. which advised NIH in 1994 on percent of the genome in a working remarkably fast-paced schedule."' He this issue, but whose recommendations draft. based on mapped clones. by the lauded NfH's appropriation for FY were preempted by Congress in encl of 200 I :· 1999 as u "really exLraordinary appropriations language forbidding A discussion ensued about the deanh increase,'' but cautioned that the federal human embryo research. of people trained in both mathematics/ spending plan "is a complex one, and Varmus hoped the I 06th Congress will statistical analysis and biomedicine­ not without controversy." He limned take up the issue of whether NTH can such folks are hotly pursued by private four deeper budget themes: harnessing fund research downstream of lhe firms offering large salaries. but there genomics, reinvigorating clinical recent work on pluripotent stem cells. is no defined academic track for research. engaging other disciplines "I'm strongly hopeful that we·n be training them. said MJTs Dr. Eric such as physics, mathematics, engi­ able to determine (whether NTH can Lander; he suggested adding neering. and bioinformatics (to handle fund the sequelne to the stem cell multidisciplinary genome career-track the vast amounts of data accumulating. work) quickly." training to the next ACD agenda. and particularly from genome studies), and Vannus pointed out that NIH hasn·t Varmus agreed. addressing health disparities both been congressionall y reauthorized Clearly impressed by Collins' within the United States and interna­ since 1993. and hoped the next presentation, meeting invitee Brad tionally. Congress would get to that. as well as Margus. a Florida businessman who is The average grant size will increase the issue of genetic discrimination, al o president and director of the A-T by I 0 percent under the new budgeL confidentiality of medical records. Children ·s Project (two of his sons Varmus said, am! the 9,200 or so new tobacco legislation, and proposals have ataxfa telangiectasia. a genetic and competing research project grants dealing with access to and reimburse­ ailment). noted. ·'It's great to have all co be funded represent ·•a very dra­ ment for clinical research. this good news about the rate of data matic increase from just a few years There were short updates on two collection, but what about meeting the ago, when the number fell to below lingering issues-access 10 research needs of patients now who have 6.000."' Regarding his I percent tools (presented by Dr. Maria Freire. genetic diseases? Shouldn't there be a discretionary fund. Varmus said he is director of the Office of Technology Human Protein Project as well?'" considering investments in synchrotron Transfer) and computers in biomedi­ Maybe ii was the coffee break that beam lines to boost structural biology cine (given by Dr. Larry Smarr. occun-ed at this point. but when the Sllldies. and increased spending on director. Nati onal Center for advisors returned. some were rather mouse genome research. Supercomputing Applications. Univer­ feisty. An overview of improvements ·'As I teamed when £came to NTH, sity of Lllinois)-before Collins gave a to the intramural programs in the last we're always working on three budgets lively repo1t bookmarked by two 5 years given by NIH deputy director at any one time. maybe four," he said, quotes: the famous admonition to for inu·amural research Dr. Michael noting that he is negotiating with HHS ··make no little plans·· by architect Gottesman included a propo al to craft over the level of the President's budget Daniel Burnham, and the pithy, "L-0w an NIH Academy (see sidebar), which request for 2000 and 200 I. Two big aim, not failure, is a crime." Collins would include a small graduate themes for the FY 2000 budget. he says he sees his instilllte's work as a program emphasizing clinical research predicted. will be health disparities "feeder layer"· for the rest of biomedi­ and drawing from a diverse student and bioengineering. cal research and said NHGRJ's goal is pool, including underrepre ented Varmus described his Dec. 2 Senate ·'sustained sequencing capacity." The minorities. hearing as "'a tremendously upbeat genome project intends to finish the "Docs this coumry really need conversation. with Senators (Tom) human genome sequence in 2003. another Ph.D. program?" wondered Harkin CD-Iowa) and (Arlen) Specter coincidentally the 50th anniversary of Dr. Shirley Tiighman. professor of (R-Pa.) pitching in.'' and briefly the double helix discovery. Intermedi­ molecular biology at Princeton outlined the history of the current ate goals include finishing one-third of University. "Every graduate school in federal ban on research involving the human DNA sequence by 200 I, the U.S. is already straining to human embryos. He looked back which Collins said would likely yield improve diversity already. I'm not

12 SPRI N G 1 9 9 9

persuaded at all that there is a need." a Council of Public Representatives two clashed briefly over bow seriously The Post's Graham asked if busy (COPR) and offices of pub.lie liaison in NIH takes the issue of assessing the sciemists would be willing to set aside each institute and center as well as the burden and cost of disease in allocat­ research Lo spend time in the director's office. A COPR with some ing research dollars. classroom. 20 members selected by Varmus is due "There seem to be Lwo extremes of Gottesman coumered that N1H offers to be named later this spring, said conception about NIH priority­ unique opportunities for clinical Anne Thomas, NIH associate director setting,'' Vannus explained. ''There's research, a field in which highly for communications. the ' King and His Counring House' specialized training is much needed, ''Of aH the government institutions 1 model. where I push piles of money in and boasLs "a fairly sizable number of know, NLH has the most extraordinar­ certain di rections, and the Tolstoyan minority role models." Tilghman ily rich interactions with the public,'' model, where there are many soldiers suggested a training Request for said Varmus, who envisions COPR and many trenches, each ignorant of Applications to accomplish Nlffs collaboration on such occasions as his the other's battle." Neither ex u·eme goals. which she ad mi tted were annual budget retreats, major policy does credit to the actual effort NIH laudable. Varmus divulged that one discussions on topics such as embryo makes. he argued. model for an NlH Academy. of which research, and in NTI-l 's conformance Varmus concluded. ·'(The !OM the graduate program would be a small wjth the Government Performance and report) is not a blueprinc for what NIH parL, is the Meyerhoff scholars Resul ts Act (GPRA), passed by is going to do nex t." He said a letter­ program at the Universi.ty of Mary­ Congress to monitor the success of by-letter response to the recommenda­ land. Baltimore County, which federal programs. ti ons is inapprop1iate. intensively trains undergraduate Vannus seemed upset that The daylong meeting concluded with minority students. "(The Meyerhoff Rosenberg's panel did not evidently a discussion of issues involved in program) is the inspiration for this appreciate how thoroughly NIH clinical trials, including the effort to idea," he said. "lc's someching we're understands the complicated factors assemble a one-stop clinical trials guice well positioned to try to do." influencing priority-setting, and the database, housed at NLM. As others weighed iJ1 on the focus and size of the grad school, Vannus tabled the discussion until a specific Plan Outlined for 'NIH Academy' proposal can be made ac the next ACD Some months ago, NIH director Dr. Harold Varmus asked Dr. Harold meeting in June 1999. Slavkin, director of the National Instirute for Dental and CraniofaciaJ Re­ Next, anticipaLing some rancor in the search. to chair a committee for recruitment of a diverse workforce in medical discussion of priority-setting, Varmus research. The committee was asked to prepare recommendations addressing introduced the topic by noting that the underrepresentation of minorities in biomedical careers, and medically budget increases of 6, 7 and 15 percent underserved populations within the U.S. in the pasL3 years bave brought The Slavlcin comminee·s Ei rsc prescripLion is creation of an NIH Academy heightened congressional and public "to serve as a nexus for recruiting and training a diverse population of studenrs interest. Ln 1997, Congress directed to pursue careers in the health sciences. The Academy would operate as an TOM to examine NIH's method of intranmral program on the NIH campus and as an extramural program within setting research priorities, and a 19- academic health sciences institutions throughout the Uniced States. The member panel Jed by Princeton's Dr. recommendation will also require increased funding levels for training to Leon Rosenberg spent 5 months last reali ze the desired outcomes and increase the talent pool engaged in medical year drafting 12 recommendations to research." improve the process. "We believe A successful academy would depend on five "cri.tical elements": a dedicated there is room for more lay participa­ cad{e of mentors full y supported by the institution; a residential facil ity to ti on in every level of Nl:H 's activities, Foster community and purpose: continuity of support to nurture trainees, and that NIH would be strengthened potentiall y from high school through postdoctoral training; public and private by so doing," said Rosenberg. Recom­ funds to cover various financial needs as trainees make the transition to the mendations 7 and 9 form the heart of extramural environment; and opporttmities for work on research problems in the critique, directing NIH to establish communities close to various academy locations.

13 N I H A A UPDATE

Budgets, (continued fro1n p. J) full-time employees. Exploiting Genomic Discoveries The omnibus measure also: continues The Human Genome Project will be status for the former Office of rhe NIH director's authority to 1ransfer accelerated by i.ncreasing capacity at Alternative Medicine, which is now funds between appropriations (limited major sequencing centers. Due to a the National Center for Complemen­ to I percent of the budget); provides number of methodological advances tary and Alternative Medicine (with a $500,000 to the Foundation for the and increased resources, the expected $50 million appropriation), and NIH (formerl y the National Foundation completion date is now 2003. 2 years renaming of the National Institute of for Biomedical Research, which is earlier than originaJly projected. Dental Research, which has elongated permitted to raise funds and donate In FY 1999, NIH began the Mouse to National Institute of Dental and them to NIH); offers $90 million in FY Genomic and Genetics Project that Cranjofacial Research (NIDCR). 1999 plus advance funding of $40 wiJJ serve the research community The new Consolidated Laboratory mi Uion- avai Iable Oct. I , 1999-to by developing a laboratory tool for Facility, now under construction as complete the new Mark 0. Hatfield physiologists. developmental biolo­ Bldg. 50. wi!J be named in honor of Clinical Research Center: and allocates gists, and neurobiologists to better Rep. Louis B. Stokes (D-Ohio), and $ 10 million for vaccine research and understand mammalian biology. the new Vaccine Research Center development activities in support of the The research wi ll be continued in (B ldg. 40), on which work has already President's bioteJTorism initiative. FY 2000 to define the structure of begun. wi ll be called the Dale and AIDS research is identified at $1.799 lhe entire mouse genome and identify Betty Bumpers Vaccine Research billion. The biJJ continues the federal the function of mouse genes by FaciLity. Off-campus construction prohibition on human embryo research. studying gene mutations. Eventually also got a boost as $30 million was Other emphases within the budget the genomics of other organisms will provided for NCRR-sponsored law include establishing two to five be determined and used as model extramural buiJding projects. "mind/body'' centers, bolstering the systems for learning abouL human The FY 1999 appropriation will number of African American investiga­ genes and proteins and for testing enable NTH lo fund more than 9,000 tors invol ved with HIV research new lreatments. research project grants (RPGs) this (including prevention and risk­ Engaging Other Disciplines in year, and allow the agency to make reduction), and helping lhe Institute of Medical Research significant progress in its goal of Medicine complete a study on cancer Optimal use of the vast amou nt of paying close to recommended levels among minorities. data being generated from genomic for RPGs, noted Francine Little, research will require increasingly director of the Office of Financial The President's 2000 Budget sophisticated bioinformatics systems Management. The salary cap for requiring the collaboration of researchers financed through grants President Clinton's FY 2000 budget researchers from many disciplines, and contracts also has been raised provides $ 15.9 billion for NlH, a including physicisrs, mathematicians, from $ 125,000 to executive level l II $320 mill ion increase (2. 1 percent) chemists and bioengineers. Advances (curremly $ 125,900). over the 1999 level. Foreseen in tbe are foreseen in imaging technology, Clinical research. too, has been investment is a continuation of rationa.I drug design and structural bolstered by creati on of three new "K" advances in fundamental science, biology. award programs expected to increase especially in genetics, structural Reinvigorating Clinical Research significantly lhe number of clinical biology, molecular and cell biology, The emphasis will be increased investigators. NIH is also going to be neuroscience, computer science and support of General Clinical Research able lo provide an across-tl1e-board imaging technologies. Centers, more clinical trials, new stipend increase of 25 percent for These scientific efforts can be programs to develop clinical recipients of National Research summarized as addressing four biomarkers in immune diseases, and Service Awards. Trainees, visiting research themes: exploitation of expanded training of physician fellows and volunteers will also gain genomic discoveries; interdisciplinary scientists (including new grant lransit subsidies as the law provides research; rei nvigorati on of clinical programs to support training and NlH permanem au thority to offer research; and elimination of health mentorship of young doctors aiming Transhare to a wider pool than just disparities. for careers in clinical research).

14 SPRING 1 g g g

Eliminating Health rnsparities There will be a renewed emphasis on Update on Two Building Sites on Campus research to understand the causes of disease; to identify and increase knowledge of risk factors for disease; tO determine reasons for health dispari ties that may be associated wid1 race, ethnicity, gender or socioeco­ Bldg. 50 rises at the nomic status; and to understand the corner of Center and role of personal behaviors and South Drives. In the environmental factors iJ1 health background is Stone disparities. House and the Natcher Mechanism Discussion Center. A placard recently erected outside Jn FY 2000, NIH will suppon 7,617 the site officially competing research project grants. desi gnates the structure Support for RPGs, including Small as the Louis Stokes Business Innovation Re-seru·ch and Laboratories, named Small Business Technology Transfer after the retired awards wi ll increase by nearly 3 congressman from Ohio percent over FY 1999. NIH will who had been a suppo11 nearly 15,700 pre- and longtime supporter of posrdoctoral trainees in fuJl -time medical research. training positions, approximately the same number as in FY 1999. Stipends will remain al the FY 1999 levels. NIH will participate in two Presiden­ tial initiatives: l) Information Technology for the Twenty-First Century Initiative (IT2) primarily in three areas: software and algorithm research and development in support of genomics, clinical trials and bioinformatics; rugh-d1roughput, low­ The Vaccine cost clusters of processors drnt can Research Center provide performance needed in site adjacent to laboratories for mid-range, high­ Bldg. 37 takes performance computing; and training shape as the and grants to encow·age physicists, fast-track project engineers, mathemati.cians and gets under way computer scientists to advance in earnest. The computing in biomedical research. building is The FY 2000 request includes $6 scheduled for million for this initiative. 2) NIH will completion in 2000. also continue to address bioterrorism activities with an emphasis on microbes such as smallpox and anthrax. This research is conducted in collaboration with d1e Department of Defense.

15 N I H A A U P D A T E

Science Research Updates

Oral Complications of Cancer may tolerate only lower. less effective team directed by Dr. Altaf A. Lal of Treatment Targeted by NIDCR doses of anticancer drugs. may the CDC describes a new candidate postpone scheduled treatments. or vaccine that targets the malaria Most cancer patients don't know that discontinue treatment entirely. Oral parasite at several stages of its life visiting a denList can make a differ­ side effects can also be the source of cycle. ence in their cancer treacment. A new systemic infections that may interfere The scientists combined segments of health awareness campaign from the with cancer therapy and even threaten 21 different P. falciparum proteins to National lnstitute of Dental and patient survival. form a single recombinant protein, Craniofacial Research explains how which they used to immunize rabbits. proper oral care can prevent or Promising New Malaria Vaccine Each of the 21 segments. or peptides. minimize painful complications in was selected because it was recognized the mouth that affect up Lo one-third A team of researchers, including by the immune systems of people with of patients undergoing treatment grantees of tbe National Institute of malaria, as shown in earlier studies. for cancer. AJlergy and Infectious Diseases, has Furthermore. the peptides targeted Of the 1.2 million Americans reported positive results of research different branches of the immune diagnosed with cancer each year. on a new, broad-based malaria system: B cells, helper T cells and approximately 400.000 will develop vaccine. A paper describing their cytotoxic T lymphocytes. oral complications from their treat­ findings appears in the Feb. 16 issue Laboratory tests showed that the ments. Many patients, dentists, and of the Proceeding.~ of the National vaccine induced a high level of oncologists, however. are unaware Acc1demy of Sciences USA. antibodies that recognized the of the right steps Lo take to prevent Health officials have long sought a parasite at different stages of or manage these potentially serious vaccine to prevent malaria. a disease development. The antibodies also problems. that affects 300 to 500 million people blocked P. fafciparum invasion into "Oral Health, Cancer Care and You: and kills up to 3 million people the rabbits· liver cells and inhibited Fining the Pieces Together" informs worldwide each year. "lmproving growth of the organism in their blood. health care providers and patients international health is a high priority Although the researchers have not about what they can do to reduce the of the NlAID, and malaria research is yet looked at the T-cell responses risk and impact of oral complications. a major area of interest," comments in vaccinated animals. these studies NIDCR is conducting the awareness Dr. Anthony S. Fauci, director of the are under way. campaign in partnership with NC I, institute. "Although these results are "Mul ticomponent vaccines may offer NINR, CDC and the Friends of the preliminary and the candidate vaccine an advantage over single-component NIDCR. has yet to be tested in people, its vaccines because they may provide Oral complications can result from effectiveness in laboratory tests multiple levels of protection against all forms of cancer treatment, includ­ makes ii an interesting candidate for different parasite stages." says Dr. Lee ing radiation Lo the head and neck, further study." Hall program officer for parasite chemotherapy for any type of cancer, The most severe form of malaria is vaccine development at NIAID. "Such and bone marrow transplantation. caused by a microscopic parasite, vaccines may also reduce the spread of Among the most common complica­ Plc1smodi11111 falciparum, that is vaccine-resistant strains, which can tions are painful, inflamed gums; transmitted to humans by mosquitoes. arise when a pathogen changes a mouth ulcers; bleeding; infection; and The parasite has a complex life cycle. surface protein to avoid detection by salivary gland dysfunction that leads Following injection into the blood­ the immune system." to dry mouth and rampant toolh decay. stream, it rapidly travels to the liver Oral side effects may be acute, or they where it multiplies. New fonns of the may last a lifetime. parasite are then released into the Oral complications can affect cancer bloodstream where they invade red treatment as well These conditions blood cells, ultimately destroying can be so debilitating that patients them. In their recent paper, a research

16 SPRING 1 9 9 9

Transitional Care Improves 14.5 percent for controls. Per-patieOL undergoing hysterectomies. Health of Elderly Patients days in the hospilal were fewer for the Naylor is continuing her research on intervention grou~ l .53 versus 4.09 tbe transitional care model for patients Older people with common medical for controls. and the costs of posr­ with heart failure. who did not fare as and surgical problems. who were discharge health services were aboul weU in her smdy. This group will be discharged from the hospiLal following $600,000 lower. followed for one year after hospital treatmenL, reali zed a signiticam "Many patients in the study were discharge. Naylor explained that "It is improvement in their health at reduced coping with an average of five active difficult for patients and Lbeir costs to the health care system, physical and emotional problems:· caregivers to manage hean failure according to research published in the said Naylor. "When one considers the symptoms, and patients often have Feb. 17 issue of the Journal of rlie number of frai l older people hospital­ trouble changing certain risky behav­ American Medical Association. The ized each year with similar conditions. iors that contribute to poor general smdy. "Comprehensive Discharge the potential benefits to the patient and health. The good news is that past Planning and Home Follow-up of savings to the health care system can studies indicate that between one-third HospiLalized Elders," tested a model of be tremendous." and one-half of hospitalizations for transitional care. IL was led by Dr. A randomized sample of 363 patients heart failure are preventable:' Mary Naylor, of the University of over 65 years of age were assigned to Pennsylvania's School of Nursing and either Lbe group receiving transitional supported by the Nalional Institute of care or a control group that received Nursing Research. routine care. Patients in the transi­ "'This research addresses an impor­ tional care group were visited by Recruitment Information for tant area of compelling need for advanced practice nurses within 48 Patients and Doctors scientifically tested interventions," hours of hospital admission and said Dr. Patricia A. Grady. director of received home visits up to four weeks At the Patient Recruitment and NINR. "The study focuses on a high post discharge. The same nurse who Referral Center (PRCC). nurses risk group of older Americans who are prepared the patient for discharge also are available to answer questions living with chronic illness. Since the provided the home follow-up. The and send information about the elderly in our socieLy are living longer nurses were available for daily NIH clinical research program. the and their numbers are expected to consultation by telephone and coordi­ more Lhan 800 clinical research increase significantly, health care nated care with other members of the studies currently under way and professionals need feasible straLegies health care team. Patients received the admission process. such as lhe transitional care model to comprehensive care that included Staff can also refer physicians to help patients Live healthy. independent clinical assessmenr, monitoring, the appropriate NIH contact to get lives for as long as possible," she said. management of symptoms, caregiver more details about Lhe individual The model uses a multidisciplinary education and assistance, and infom1a­ studies and lhe criteria for patient team and involves comprehensive tion related LO maintaining health. referral. discharge planning, including determi­ According to Naylor. "The transi­ Contact the PRCC for more nation of patient care needs outside the tional care model is in sharp contrast information about panicipating hospital, and fo.llow-up in the home by with current practice, which leaves in NIH clinical research smdies: advanced practice nurses specializing most patients, once discharged, on 1-800-4 11-1222: email in geriatrics. Findings revealed that their o~vn to obtain necessary follow­ [email protected]. six months after discharge, only 20 up care." In other NINR-supported percent of the intervention group was studies, the model bas been tested with rehospitali zed, compared to 37 percent highly favorable results in patient of controls; and only 6.2 percenL had populations ranging from pregnant multiple hospital readmissions versus women with diaberes to women

17 N I H A A UPDATE

R&W Timeline The summer issue of the NfHAA Update contained a comprehensive Iisr of the institutes, centers and di visions at NTH, which prompted Randy Schools, R&W president, to compose the li st of important R&W milestones tbat is shown below.

1945 Early stages: club system 1982 Loan program stopped. 1994 R& W Foundation conducts begins; early clubs include 1983 Vendor program begins; community fu ndraisers. softball and bowling. Friends of the CC formed 1994 Westwood store closes. 1953 CLinicaJ Center opens. 1983-84 R&W cited in talks to federal 1995 Rockledge fitness center 1956-57 R&W Store opens in CC; executive boards. and store opens; National Tbeater Club and NIH 1986 R&W given Best in Federal Marine Sanctuary formed. Orchestra perfonn for NTH Government Reagan award 1996 R& W mentioned in three communi ty. for community service. employee service books. 1960's Bldg. 31 R&W Store opens. 1987 R& W earns Eastwood 1997 Quality of Worklife Program 1968 Film desk, Westwood store. Award for best programs in planning begins; R&W assists 1969 Tennis courts opened. the United States. in fonniog and fondraising 1970's Professional services offered. 1987-90 Planning for Children's loo with Soaring for Children: 1972 Westwood store enlarged. begins, and R&W runs WGAY-FM begins N1H 1973 North Carolina store opened. business offi ce. Charities Film FestivaJ; fi rst 1980 Adventure Lrips begin; 1987-88 Lifestyle activities begin. CFC Chili Cook-off, Small group nights ini tiated 1988 Fitness Center opens in Bldg. Business Conference. (i.e., theater, Orioles base 3 1 (includes martial arts). 1998 R&W, with MCI Center and ball); NLM store moved to 1989 Squash courts open. Feld Entertainment, sponsors new site. 1990 R&W receives George Bush premier evening of Ringling 1981 Vending machines lose (R&W award; R&W assists with Bros. and Barnum & Bailey loses over $ 100,000 annual first Back to Bethesda event. Circus-tickets given to revenue to Blind Indust1ies; 1992 Bldg. 10 store remodeled; more than 2,000 hospitalized EEO weeks observed (i.e., NOAA ti e begins. children; R&W involved in Black History, Hispanic 1993 Trade shows begin ; Connect planning for the N1H Guest weeks); Fitness Center opens; 93-Vacati ons begins: House; R&W assists in Bldg. I 0 donates trailers with Jeff Bostic Celebrity Golf heaJch fair; at NOAA, begins R&W assistance; Camp Tournament held with relati onship with National Fantastic begi.ns. GE E lfon; EPS store opened. Severe Storm Center.

Shows by the Hamsters, the NIH theatrical group , were among R&W 's most popular early activities. Here, the entire cast of the 7th annual production (Dec. 1957) of life at NIH -- "Taken for Granted," assembles for deserved curtain calls.

18 SPR I NG 1 9 9 9

Framingham Heart Study Celebrates 50 Years By Louise Williams America toward prevention. .. he disea es." He stressed thac prevention The autumn afternoon was stiningly added, " giving the message that through public education has 10 become hot and the non-air-conditioned, stately people can control their own desLiny." a way of life in America. "Too few Memorial Building in Framingham. LenJant thanked participants for their physicians are putting prevention into Mass .. was packed. But the thousands ·'dedication and enom10us contribu­ practice," he aid and caJ led for a gathered there didn' t mind. They'd tions to the study and to medical worldwide effon to promote healthy come to celebrate an extraordinary knowledge. The study could not have lifestyles. anniversary- the 50th year of the succeeded without the commitment of Current FHS director D r. Daniel Levy Framingham Heart Study (FHS), the the people of Framingham:· called his staff the " unsung heroes" of longest running epidemiological study His thanks were echoed throughout the Framingham story. '·You and the in U.S. medicine. the aftern oon. Dr. Aram Chobanian. ordinary citizens of Framingham have The attendees-who included U .S. dean of Boston University's School of advanced our understanding of coronary surgeon genera l Dr. David Satcher, M edicine, who has used Framingham heart disease:· NHLBJ director Dr. Claude Lenfam, data in his research, said, ·'Thank you He also pledged th at the Framingham past FHS directors and the current for all you have done for cardiology. story had onJ y begun. ·'Today and in director. congressmen, state representa­ medicine. and all the people in the future years. Framingham will continue tives, T V j ournalist Dr. Timothy United Stales." to have a great impact on many lives. Johnson. and more than 1.500 PHS Satcher. who gave the afternoon's We and you are not done ye1:· staff and participants-had a lot to keynote address. al so thanked the He said studie under way cover such celebrate. Since its start in 1948. the Framingham panicipants for their topics as early identificaLion of CYD in FHS has saved and improved countless "commitment. dedication, and those still free of symptoms. investiga­ lives in the U.S. and worldwide. perseverance." He said he'd asked tions of the genetic causes of CYD. The town or Framingham is 18 miles himself what makes FHS so special arthritis. and osteoporosis. and more west of Boston. The study. part of and came up with six key factors: research on racial and ethnk differences NHLBI. began with 5,209 healthy The study is scientifically rigorous. in risk factor development. Framingham residents. ages 30-60- longiLudinal. community- and family­ The afternoon also brought congratula­ about 20 percent of the town's popula­ based, and has always involved men tions from President Clinton. But tion-and grew to include 5, 124 of and women. and most of all has mostly, it was a demonstration of the their children (and their spouses) in an mutual trust between participants and bond that exisL'i between FHS's panici­ Offspring Study. Recently. 500 sta ff. "The issue of trust and it pants and staff. who took time before Framingham minority residents were development is a real challenge," he and after the formal presentations to recruited to form the Omni Study. said. "And Lhat·s Lrue whet.her about a warmly thank each other. FHS's many achievements include study or any kind of medical care in Participant spokesperson Jay Lander, discoveries about the relations between the United States." a member of the OITspring Stud y, risk factors and cardiovascular disease He said Framingham changed how described how many fell about being (CYD). The FHS helped make Ameri­ people look at health and disease. pan of FHS. "We go through life. most cans aware of the health dangers of "Before, a lot of people. especially of us," he said. ·'knowing only the effect high cholesterol, high blood pressure, when it cam e to cardiovascular we have on the people around us... Only physical inactivity and smoking. lt also diseases. thought it was a mauer of a small percentage of people get to make has published lindings on such topics luck or fonune. Framingham shows a permanent contribution to humaniry:· as psychosocial factors and hean that it's not j ust that but how people He added, ·'But this study has given di sease. diabetes, obesity and dementia. behave ... including the dangers posed each of us in Framingham ome small As Rep. Edward J. M arkey (D-Mass.) by risk factors. role in producing a lasting achievement ,•· told the crowd, "T he thousand scien­ He added that " Framingham shows and ··as long as the planet is inhabited. tific papers produced by Framingham us that just as we use the public health the contribution of Framingham to the have become the holy book·' of approach in infectious diseases. we quality of that life will be remembered:· medicine. The findings have "moved also can intervene wit.h chronic

19 N I H A A UPDATE

For Your Information

Former First Lady Carter Visits

Gathered Feb. 1 at NIH for "An Evening with Rosalynn Carter" (second from r) are (from I) Maryland First Lady Frances Glendening, NIH deputy director Dr. Ruth Kirschstein and Janyce Hedetniemi , director of NIH's Office of Community Liaison. Former U.S. first lady Carter spoke about her efforts on behalf of mental health. The event was cospon­ sored by OCL and NIMH.

South Entrance to Clinical Center Debuts

On hand to cut the ribb on officially opening the CC's new South Entry on Jan. 11 are (from I) CC deputy director for clinical care Dr. David Henderson , NIH deputy director Dr. Ruth Kirschstein, NIH deputy director for intramural research Dr. Michael Gottesman , NIH director Dr. Harold Varmus and NIH Associate Director for Research Services Steve Ficca. The airy and spacious new South Entry to the CC is two stories tall and a combination of glass and honey-tinted maple veneer. Prominently displayed on the wall facing entrants, are the original metal letters spelling out Warren Grant Magnuson Clinical Center and a bold PHS shield. These accoutrements once graced the north front of what was once known as the Ambulatory Care Research Facility, or ACRF, built onto the lace of old Bldg. 10 in 1982.

20 SPRING 1 9 9 9

NIAID Dedicates a Room at CC in Memory of Dr. Sheldon M. Wolff By Karen Leight)·

On Dec. 11. 1998. NIAID paid tribute and the role of fever in infectious, ing human lcukocytic pyrogen (now 10 the memory of Dr. Sheldon M. inflammatory and immunologic called interleukin- I). a powerful Wolff, who profoundly influenced disorders. component of tJie immune system. immunology and in fectious diseases Fevers of unknown origin also Wolff left NLH in 1977 co become research and served as mentor to an attracted his attention. He not only professor and chainnan of the depa11- extraordinary number or individuals identified the immunologic defects that men1 of medicine at Tufts University who went on to distinguished careers caused many such illnesses. but also School of Medicine. He also accepted in biomedical research. found effective. often lifesaving the position of physician-in-chief at Under the sponsorship of NlA ID treatments for those conditions. Boston's New England Medical Center director Dr. Anthony Fauci, a slate-of­ Fauci and Wolff collaborated in Hospital. He maintained a close the-an conference room in Bldg. I O's dramatically i.uccessful protocols with association with NIAID, however, 11th floor solarium was dedicated in a immunosuppressive drugs for treating including service on numerous ceremony that included Wolff's widow. Wegencr's granulomatosis, polyarteritis advisory committees. family and a corps of friends and nodo a. and other y temic necrotizing WollT died of complications after a former colleagues. vasculitic disorders. long illness in 1994. His contributions ''Shelly Wolff was my professional Together with another colleague. Dr. to biomedical research serve as a father. my mentor. my closest friend,'' Charles Dinarello. WollT also made symbol of both the achievements and said Fauci. ''He continues to be revered impo11ant contributions to understand- the goals of NIA ID. at NIH and througboul the extramural community. His vision, remarkable work ethic. and keen attention to the Glenn and the 'Discovery' Crew Visit NIH, Recount Space Journey development of che careers of younger physician-scientists left an extraordi­ nary legacy:' Wolff began his NTH career in 1960. when he joined NIAID's Laboratory of Clinical Investigation (LCJ) following his medical residency. Within a short time, his strengths as an investigator. clinician. teacher and administrator bad infused tJie lab with new vigor. He subsequently became N IA ID clinical director and chief of LCI. Under his leadership, LCI became one of the most productive and respected clinical research teams in tbe country. The thread that tied Wolff's bench NIA director Dr. Richard Hodes (I) welcomes Sen. John Glenn to NIH. A workshop held by science 10 his work witJi patients was NIA and NASA on Jan. 8 filled Masur Auditorium (and several overflow rooms) to capacity his dedication LO the study of fever. His to hear Glenn and the rest of the crew of Space Shuttle Discovery Mission STS-95. After a early investigations stemmed from the thundering standing ovation, the 7-member crew guided the audience-via a 20-minute fundamental question: Why docs the film and slide show-through the mission's 9 days in space. At the end of the visit, Gl enn body produce heat in response to an paid the following tribute: "That's why I was particularly glad to come out here today-to invasion of microorganisms? In say thank you to all of you folks here who, through Secretary Shalala, Dr. Varmus, Dr. pursuing this question. he made major Hodes and others, make NIH programs work. II means so much, and not just to us here. comributions in elucidating the causes We have such an increasing life expectancy for our own people and for people around the of fever, the elTects of fever on the ho t. world, and much of the credit goes to you right here at NIH. So thanks to all of you. "

21

N I H A A U P D A T E

American College of Laboratory Animal Nm Funds Support Nobel Laureates Medicine at the college's L998 forum in St. Charles. UL TI1e award was given ro The three I998 Nobel laureates in physiology or medici.ne-Drs. Robert Furcbgott, Schech for scoring highest o; a certifying Louis Ignarro and Ferid Murad-all enjoyed. like many of cbeir predecessors. years exam given by the college: he had the top of NIH grant support for their prizewinning investigations. score on both Lhe 1997 wrinen and practical The crio were recognized for basic discoveries about nitric oxide. a gas the body uses examinations ... Dr. William S. Stokes, in many physiological funccions ranging from dilating blood vessels (its actions led to associate director for animal and al ternative the creacion of Viagra to treat impotence). regulating blood pressure, to sending signals resources, NlEHS. has received a certificate to the nervous system. of recognition from the Humane Society of ln addition to their funding connection to NIH. two of the laureates served on study the United SLaLes under its Russell and sections: lgnarro was a member of he phannacology study section during 1982-1 985 Burch Awards program for outstanding and Murad served the same section from 1984 to 1987. contributions toward the advancemem of Of the 75 American Nobel laureates in physiology or medicine since 1945. 56. or alternative methods of toxicity testing ... more than two-chirds. either had worked at or were support.ed by NlH before winnino Dr. Harold Varmus, NlE director, recemly the prize. Since World War U, 118 scientists worldwide have been awarded the Nobcl delivered at NIEHS the 14th Hans L. Falk prize in physiology or medicine. More than half of them (66) had prior support from. Memorial Leccure on "Making a Mouse or worked nt NIH before the honor. Model for Gl.ioma," which presemed work in his NCI lab ... Dr. John T. Watson, acting deputy director. NHLBl, has become the first scientist from NlH to be elected to the National Academy of Engineering. He vaccines and their future utilization" ... Dr. and their families" ... Dr. Alan Le.c;hner, was selected for his work "enabling human Stephen J. Katz, NLAMS director, recently NIDA director, was elected to membership mechanical artificial bean research and received the Scleroderma Foundation· s in the Institute of Medicine of the National developing the related NlE grogram, Message of Hope Award for 1998 for his Academy of Sciences ... Dr. Yoshitsugu including .industrial implementation" ... Dr. involvemeOL in convenfog the NlAMS Miyazaki, a Fogarty visiting fellow in Scott Whitcup, NE! clinical director, has workshop, "Emerging Opportunities in NlAID's Laboratory of Clinical Investiga­ received the fust Uveitis Study Group Prize Sclerodem1a Research" and for bringing tion in the clinical mycology section. was for his research on ocular inflammatory focus to scleroderma re,~earch ... Dr. recently honmed as one of rwo recipients of diseases ... Dr. Peggy Zelenka, chief of the Leonard David Kohn, a sciemist with the Merck Irving S. Sigal Memorial Award. section on cellular differentiation in the NIDDK's Metabolic Diseases Branch, The award. presented for the first time, Laborntory of Molecular and Developmen­ received an honorary degree in medicine recognizes young investigators who bave ral Biology, NEl. received the Alcon and surgery from the University performed significant research in microbi­ Research Institute Award for ber outstand­ d' Annunzio in Chieti. Italy. Re has ology and infectious disease and reside ing contributions to vision research. The pioneered the study of the regulation. outside North America ... Eleanor Nealon, award recognized her recem work on the growth and function of the thyroid cell and director of NCI's Office of Liaison process of cell diffe.rentiation in the ocular has also worked extensively on the role of Activities, received an award from the lens. the TSH receptor in autoimmune diseases ... Cancer Research Foundation of America Dr. Mark Lane, an NIA investi1rntor in the ''for helping others to have access io the Gerolllology Research Cent.er, r;ceived the best cancer infom1ation" ... Dr. Robert Retirements 1998 Nathan G. Shock New investigator Nussenblatt, NEl sciemific director, has Award for his research on imervention been elected 7 l st. presidelll of the Associa­ J ohn H. Jones, deputy executive officer at strategies using both primate and rodent tion for Research in Vision and Ophthal­ Nli"IDS. recently retired after 34 years of model systems. and for developmelll and mology. a nonprofit, scientific organization government service. He began at NTH in evaluarion of biomarkers of aging ... Dr. of over 9.000 eye and vision researchers the NINDS Eleccroencephalography Claude Lenfant, NHLBI di~ct;~. recently throughout the world ... Dr. Kenner C. Branch, but switched in 197 l to an received the Natl1an Davis Award of the Rice, chief of l\'IDDK's Laborarory of administrative position and continued on American Medical Association. He was Med.icinal Chemistry. received the 1998 that career path. ln 1990, he became cited for his "oversight of groundbreaking Research Achievement Award in Medicinal deputy executive officer, the position be research and clinical trials that have and Natural Products Chemistry from the held at the time of his retirement. With the revolutionized the prevention and treatment American Association of Phannaceutical exception of a brief detail assignment from of heart disease, stroke and other pulmo­ Scientists. The award recognizes his 1996 to 1997 as acting executive officer for nary and blood disorders." He also received research in the mechanism of action of DRG, Jones served his entire NIH career at from the American Society for Blood and abused drugs and in Lhe tre~tmen t and NLNDS. His retiremem plans include visits Marrow Transplantation its first Public prevention of drug abuse ... Dr. J oseph to see siblings, working on home improve­ Service Award for ·'contributions to medical Schech, a clinical laboratory animal ment projects and gardening ... Rev. research and public health policy that have veterinarian at NICHD, recently received Eugene Linehan, S.J., Catholic chaplain in benefitted bone marrow transplant pariems the Henry and Lois Foster Award of the the CC spiritual ministry department,

24 S P R N G 1 9 9 9

her procurement knowledge in the purchase professor and chairman. department of Eleven Named AAAS Fellows of two mass spectrometers for the Division pediatrics. University of Washington School of Basic Sciences. NCL re ulting in of Medicine. ln I 962. Aldrich was asked Eleven NIH'ers are among the 283 considerable savings. Payne plans to enjoy by the Kennedy adminisrrmion to help scient is ts recently elected by their her retirement by traveling and taking found. staff and chan the future course for peers to the rank of fellow in the several cruises ... Dr. Clarice Reid, di.rector NlCHD. After he left NICHD. he returned Ameri can Associati on for the Ad­ of the Division of Blood Diseases and to Lhe University of Washington Medical vancement of Science. They received Resources. recently retired from NHLBI School to head the division of health a certi ficate and rosette pin at the after 26 years of federal service. She first resources and serve as president of the AAAS annual meeting in Anaheim. joined NHLBI on a detail in 1975, and later university's faculty senate. In 1970. he Jan. 23. 1999. became national coordinator of its sickle became vice president for heahl1 affairs at The new AAAS fell ows from NIH cell disease program and chief of its Sickle the University of Colorado. then rerumed to are: Drs. George W.A. Milne. Ira Cell Disease Branch. She became DBDR the University of Washington in 1980 to Past11n and Stephen J. O 'Brien of director in 1994. Once retired she hopes 10 work in the Graduate School of Public NCI: Dr. Bernard Moss, NIAID; Dr. spend more Lime enjoying her family and Affairs ... Dr. David Wheelock Alling, 80. Anil B. M ukherjee. NICHD; Drs. playing duplicate bridge with her husband. a physician and research mathematical Martin F. Gellert and David R. The two play in tournaments locally and statistician who bad worked at lH for 40 Davies. NIDDK; Dr. Stor y C. around the country ... Dr. Edward M. years, died of re.5piratory failure Jan. 20 at Landis. NINOS: Dr. Enoch Gordis. Schmidt recemly retired from his position Shady Grove Adventist Hospital. He came NlAAA: Dr. Lawrence E. Shulman. as a senior investigator in the Laboratory of 10 NI H in 1959 on a postdoctoral fellowship NIH/OD: and Dr. Alexa T. McCray. Neur.il Control (LNLC), NrNDS, after 26 at NHI. He also served as medical officer NLM. years of service. He joined LNLC in 1966 at NCI. ln I 960. he became a medical The AAAS. founded in I848. is the and continued to work in the field of officer at NIAID. In 1964. he became a world's largc$t federation of scientific neuroprosthetics. pioneering methods and research mathematical statistician. From and engineering societies, with over techniques. He made important contribu­ 1996 until his death. be was a special 282 affiliated societies and 144.000 tions 10 knowledge about huw individual assistant ror biostatistics in the office of the members. nerve cells in the motor cortex of the director :u the Clinical Center ... Louise C. monkey brain are used during voluntary Anderson, chief of the CC Nursing recently retired. In 1972. he joined the movements. He used his research 10 work Department (1964-1972), died on Sept. 24 chaplain staff at the CC planning to stay for on a '"visual prosthesis'· system that has the at a nursing home in Mars. Penn. She had a shon time, but he stayed for 26 years of potential to provide visual perception in Alzheimer's disease. In 1955. she came 10 service that turned into a "wonderful blind people. Schmidt and his wife have Lbe CC as assistant chief of the Nursing experience that words can't explain·· ... Dr. moved 10 Easton, Md .. and hope to use their Depanment. During her tenure. the Bruce Maurer has retired from govern­ boat as much as possible ... Nancy depanment established a number of ment service after 20 years at NrH. the last Crawford Walther recently retired from developments including the position of 15 of which were with DRG (now CSR). NlAMS where she was a computer clinical nurse ex:pen~mployees in this He stancd out in 1978 through the Grants specialisL She is looking forward to being capacity are consult.ants in specialized areas Associates Program and then worked at active in retiremenL She and her husband who work with nurses. She also initiated NIA and NCI umil joining DRG in 1983. will enjoy camping. traveling and taking up the Nursing Care Conference monograph His retirement plans are ncxible. He may golf again. She aJso wants to do some series. After leaving the CC. Anderson buy, sell ruid appraise antiques, one of his teaching and volunteer work for her church. became head of a newly formed Health many interests ... Dr. Gilbert W. Meier has Manpower Development Branch in Lbe retired after 11 years as a scientific review Division of Commissioned Personnel. admin istrator with CSR. He was a Deaths Office of Personnel and Training, HEW ... .. developmental psychobiologist"" who Roscoe R. "Reds" Auvil, 87, of Redland . managed the visual scie nce.~ 2-A sllldy Dr. Francis R. Abinanti, 82. a veterinarian Md .. died Aug. 12 at Shady Grove section and then moved to a srudy section in who worked at NIAID . died July 12 in La Adventist Hospital. He had worked as a the AIDS and related research group. His Jolla. Calif. He was in the PHS and did gardener for NIH at both Bethesda and retirement plans include a move to Austin, research on diseases transmissible from Poolesville before retiring in J 972 after Tex .. to be near his son and daughter-in-law animals LO man. In 1970. he was appointed many years of service. Once retired, he ran and grandchildren ... Sarah P. Payne associate director for the extramural a fruit and vegetable stand outside his home recently retired after 35 years of govern­ program. NIAID. After NIH. he worked ar in Redland ... Eunice Helen Balaguer, 95. ment service. She began her career in April the Washington State University College of died Sept. 17 at Britthavcn of the Onslow 1963 at GSA. but spent the last l 9 at NlH Veterinary Medicine and later joined the Nursing Home in Jacksom,Llle. N.C. A as a contract specialist, first in the Division Scripps Research Clinic in La Jolla ... Dr. former Bethesda resident, she worked as a of Procurcmem and then at NCL Her Robert Aldrich, 80. first di rector of medical secretary in the Laboratory of career has been highlighted by many awards NICHD (1963-1964) died of complications Clinical Pathology. CC in Lbe 1950's and and commendations. For example, she from diabetes on SepL I 6 in Seattle. Prior 1960's ... Malvina Schweizer Balogh, 92. received a substantial cash award for using 10 becoming NlCHD director. he was a retired NlH scientisL died of a stroke Nov.

25 N I H A A UPDATE

29 ut Collington Episcopal Life Care and was appointed nutrition program ... Earl Willard Fuller, 78. of Rock Hall , Community in MitchellvilJe. Md. Her NIH officer. NIAMD. After 1964. he held a Md .. and formerly of Princeton. W. Va .. career began in 1960 and she worked as a series of key NLM appointments. In 1967 died OcL 2 in Princeton. He bad retired health science administrator helping 10 he was appointed associate director for from NIH ... Donald F. Goduin. 65. a organize the Timberline conference on program developmen1 . and 3 years later was retired public health official who had psychophysiological aspects of cardiovascu­ named associate director of that division. worked at NIAAA, died of cancer Oct. 11 at lar diseases. She retired in 1989 ... Wimam He can1e to DRG as associate director for his home in Laurel. From 1968 to 1990. he H. Briner, 72. a retired PHS captain. died statistics. analysis, and research evaluation worked for NIAAA. becoming its occupa­ Nov. 6 in Norristown, Pa. after a hean in 1970. He became deputy director of the tion program director ... Frank Mathias attack. At NIH ( 1955- 1970). he worked at division in 1972. was named acting director Holz, 85. died Sept. 7 at Pentagon City the CC practicing pharmacy and panici­ in August 1976 and appointed director in Hospital of complications related to a pated in research involving radioactive April 1977 ... Goldie M. Donaldson, 73, a stroke. He had retired in 1985 after drugs. He esuiblished the nation's second retired NCH secretary, died Aug. 14 at working 20 years at NIR where he radiopham1aceutical service. ln August Shady Grove Adventist Hospital. She had specialized in medical and dental research 1970. Briner joined the faculty of Duke joined NIH in 1944 and retired in 1980 after ... Dr. Robert ,J. Huebner, 84. died Aug. 26 Uni versity as an assistant professor of 36 years ... Sarah Fenner Dunbar, 60. died of pneumonia at the VA Medical Center in radiology and director of radiophannacy. of cancer Aug. 30 at her home in Salinas, Coatesville, Pa. He h:id suffered from He was later promoted to associate Calif. She was a nurse who during a 35- Alzheimer·s disease for 16 years. During professor and continued in tJ1at capacity year career. worked as a grants administra­ his career at NIH (1944-1982). Huebner until his retirement in August 1998 with tor. research analyst and health specialist at was one of NIH's leading investigators. emeritus status ... Elizabeth M. "Betty" NTMH. DHHS and then as a consumer making major research contributions in Carl, 79. died Sept. 18 of ovarian cancer at safety officer at FDA's Center for Drugs and vi rology. rickettsiology. epidemiology and her home in Garrett Park. She had worked Biologics. From 1988 to 1993, she was a oncology. Huebner was given many honors Cit NLH as a registered nurse for 30 years clin.ical trials specialist in the A.CDS division including the Ricketts Award. a Rocketeller until retiring in 1983 ... Dr. George Victor :it NIAID until retiring in 1996 ... Dr. Helen Public Service Award. several honorary Coelho, 80, a retired senior psychologist Dyer, I03. a chemist who retired in 1965 degrees. the Pasteur Medal. and the who worked at NlMH for 30 years. died of after 23 years with NCI. died of pneumonia Presidential NaLional Medal of Science. In cardiovascular disease Jan. 30 at hi ~ home Sept. 20 at her home in Washington. In 1961. he was elected to the National in BetJ1esda. At NCMH. he worked on 1920. she became a scientific assistant at Academy of Sciences. He had worked at cro s-cuhural migration problems and the hygienic laboratory of tJ1e PHS's NlAlD as chief of the Laboratory of assimilation. ln the 198o·s. hew~ in the Dcpanment of ChemotJ1erapy. During her lnfectiou:. Di ea.'les. In 1968. he becan1e office of the administrator of substance long career at NIH. she compiled a chief of NCrs Laboratory of Viral Carcino­ abuse and mental health services. He comprehensive index or tumor chemo­ genesis, a position he held until he retired retired in 1996. Following his retirement. therapy and publi hed more than 60 articles in 1982 ... Emily Johnson, 77. a secretary he worked on conferences about tJ1e and monographs ... Dr. .Jacob R. Fishman, who retired in 1986 after 23 years at NIH , historical con necii ons between Portugal and 68. a Washington-based psychi11u·ist who primarily with NIGMS, died of chronic hi s nati ve Goa, India. He was interested in was active in establishing substance-abuse pulmonury obstructive di sease Jan. I at Goan literature and worked on an anthology treatment programs. died Dec. 2 at Johns Suburban Hospital. She was a grants and of 20th·century Goan poets ... Dr. Cipriano Hopkins Hospital after a hean attack. ln administrator and secretary to the director Cueto, Jr., 75. a toxicologist and chemist 1960 and 1961 he was a research psychia­ of NIGMS ... Marion Anderson Jordan, who retired as chief of the toxicology trist and clinical associate at NIMH. When 77. a retired legal secretary who was active branch of NCl's carcinogenesis testinA he died. he was president of American in the League of Women Voters. died of program. died Nov. 7 at his home in Healthcare Management of Washington. lung cancer Nov. 21 at Suburban Hospital. Rockville after a stroke. He had retired and a consultant at Riverside Hospital in She was the wife of NI HAA president Dr. from tJ1e federal government in 1979 after Washington. the Maryland Treatment William S. Jordan, Jr. After she reLired. she 30 years of service. For I0 years he was at Centers in Baltimore and the Chesapeake had worked as a volunteer at NLM in the NCI, where he studied possible cancer­ Treal111ent Centers in Cambridge. He was History of Medicine Division wi 1h the causing effects of more than 200 chemicals also a director of Potomac Healthcare photogn:tphy co llect ion ... Mary Grant ... Mildred CaU1erine Parker Dougherty, Foundation ... Or. Karl Floru, 49. an FDA Keffer, 74. a secretary who retired from 88, died of cancer Aug. I0 at her home in research scientist. died of non -Hodgkin's NIH 10 years ago, died Jan. 11 at her home Washington. She had worked at NIH for 31 lymphoma Aug. 31 at lnova Fairfax in Beltsville of cancer. She had worked as a years before retiring in 1978 as chief or the Hospital. Before joining FDA. where was secretary at various agencies within DHHS employee relations branch ... Dr. Carl he was director of tJ1e division of product before joining NIH in 1982 ... Jennifer Dean Douglass, 73. fo m1er director of the quality research in the center for drug Alona Key-Russell, 52. an NCH personnel Division of Re. carch Grants. died of cancer evaluation and research. Flora had worked specialist. died of cancer Aug. 18 at her Sept. 23 nt Suburban Hospital. He had at NCI. for 16 years he was in NCl's home in Forestville. She had worked at retired from NIH in 1985. after 24 years of Pharmaceutical Research Branch, where he NIH for 19 years before taking a lea\le of distinguished service. including 8 years as served as coordinator of pham1aceutical and absence in 1996 ... Marian Joan Kirley, DRG director. He had joined NfH in 196 1 chemical development or anti-AIDS drugs 79. an administrative secretary who worked

26 S P R N G 1 g g g

at NIH in tbe I9 70's, died of cancer at her dean of the Institute of Neurology in NIH career in 1959. He was appoimed home in Leisure World in Silver Spring ... London ... Ann Car ter Garnett Marston, special assistant in the OD. He later Dr. Saral1 H. Knutti, 85, who worked for 72, died Jul y 13. She bad Alzheimer's became assistant to the deputy director and NTH for I0 years before retiring in 1974 as disease. She was the wi fe of Dr. Robert then congressional li aison for NIH budget assistam program planning and evaluation Marston, NIH director (1968-1973) and in affairs. He retired in 1979. Payne was also director at NJ CHD. died of congestive heart th at position served as a gracious hostess to active in community affairs in Garrett Park failure Nov. 29 at her home in Kennett many guests and vi sitors to NIH. She was and served as mayor and council member ... Square. Pa. Her husband, Dr. Ralph Knutti, interested in the arts and i.n education and Bruce Phillps, 84. a research biologist who a fom1er director of the NH I, died in 1994 was recognized with many honors ruld retired from NCH in 1976 af1er 36 years ... Dr. Morton Kramer, 84, a retfred awards ... Mary Maze, 69, died Dec. 23 at with NIAJD and its predecessor, died of biostatistician at NIMH, died Aug. 17 at Suburban Hospital. She had asthma She renal failure Dec. I at Suburban Hospital. Sinai Hospital i.n Baltimore of complica­ joined NIH in 1985 as an employee He did research on the intestinal amoebic tions related to a stroke. He joined 'NIMH development specialist and retired in 1992 diseases i.n the Laboratory of Parasitic in 1949 and was chief or its biometrics as a l)bysician liaison in the CC. Once Diseases. He also worked on the develop­ branch (1949-1976) and then director of the retired, she continued to volunteer at the CC ment of gem1-free animals for use in division of bi ometry and epidemiology in the Blood Bmk and at the Red Cross scienti fic experiments ... Or. Marvin .J. ( 1976). During this time. he established a desk ... Elvira M. May, 89. a secretary Podgor, 47, an NEI employee for 25 years. voluntary national reporting system of who retired in the early I970's from the died Oct. 24 at his home in Potomac. He mental health problems that is sti ll used as Medical Library at the CC, died Sepl 14 of had kidney cancer. ln 1973, he joined a policy guide ... Alice M. Laskey, 92. a congestive hean failure at Carroll County NEJ's Division of Biometry and Epidemiol­ biochemist who reti red in 1976 as chief of a General Hospital ... Evelyn Foster Miller, ogy as a statistician. I.n 1995, he was special indexing un it at the medical library 74, a retired NIH employee. died Oct. 27 of named chief of NEL's statistical methods at NIH , died Nov. 22 at her home iu a cerebral aneurysm in Raleigh. N.C. She and analysis section. He was involved in Bethesda of complications related to had worked at NIH for many years and was many of the inslitute"s srudies and devel­ di abetes ... Or. Gerald LaVeck, 7 1. the rhe secretary to the director of the CC. She oped novel approaches 10 solving difficult second director of NfCHD ( 1988-1973), retired in 1984. After she lef1 NCH , she statistical problems ... Anna V. Polissar, 58. died Sept. 20 in Seattl e af1er a brief illness. worked as an executi ve secretary with the a geriatric social worker. died of ovarian He had served as director of the NTCHD's American CoUege of Cardiology until cancer Sept. 19 at the Hospice of Washing­ Mental Retardation Prognun, (J 963-1966) retiring in 1994 ... Barbara Rice Mur ray, ton. Early in her career. she had worked in and in May 1966 he was named acting 82, a systems analyst who retired in 1988 as the developmental psychology laboratory ar scienti fic director. serving until he was chief of the systems planning branch, NCI., NIMH. She also directed a geriatric named director. During his tenure. the died Jan. 10 at Cbesmut Hill Hospital (Pa.) support group ... SaJUe Brubeck Riley, 9 I, institute reorganiz.ed, separa6ng iuu·amural after a stroke. She joined NIH in 1968 and a reti red Mo111gomery County public school and extramural research. The NTCHD was on the staff for 20 years. She was the teacher, who worked at the CC as a Red Gerontology Research in Baltimore and the widow of Dr. Roderick Murray, director of Cross volu111eer. died of cancer Nov. I0 .... Ce111er for Population Research were the Division of Biologics Control. who died Ellen Jane Ring, who reti red at the end of established during this peri od. After he left in 1980 ... Linden E Nea~ 74, a grants August 1998 as chief of the Technology NIH he served as clinical professor, management officer with NlH. died Aug. 26 Services Branch. CSR, died of cancer on depru1ment of pediatrics at the School of of injuries suffered in an auto accident in Oct. 17. She began her career with the Medicine at University or Washington unti l Mission Viejo. Ca li f. He worked at NIH for government as a GS-2 inventory clerk and he retired in 1985. He died just 4 days after 34 years, retiring in 1980 ... H. Rita Orr, advanced to GM-15 supervisory computer the dealh of NICHD's first director, Robert 76, a personnel management specialist who specialist ... Or. Martin Rodbell, 73, who Aldrich. his me111or who was influential in worked at NLM for 11 years until her received the Nobel Prize for medicine or bringing him to NTH ... Margaret ''Peg" retirement in 1978, died Dec. 20 at Sacred physiology in 1994, for discove.ring a key HaUcr Little, 89, head of preadmissions at Heart Nursing Home in Hyansville of secret of the communications system that the CC. died Nov. I, at the Wilson Health complications related to multiple sclerosis regulates the human body's cellular Care Center at Asbury Methodist Village in ... Dr. Robert Parke, .Jr., 7 1, a demogra­ activities, died Dec. 7 in Chapel Hill. N.C., Gaithersburg. She joiJ1ed NIH in l 958 as pher who reti red from NCI in 1.99 1, di ed where he was being created for cardiovascu­ secretary to Dr. Roderick Murray, and after Nov. 5 at his home in Alexandria. He had lar problems. Despite heart surgery a being a secretary for Ors. Harold Dorn. mantl.e cell lymphoma, a form of non­ decade ago, Rodbell had co111inued to work Nom1an Topping. James A. Shannon. she Hodgkin "s lymphoma. Aller worki ng in the on cell signal transmi ssion, completing 42 returned as Murray's secretary. She retired Washington area. he joined the NCI staff. years at NIEHS and other components of in 1970 ... Or. G. David Marsden, 60, a where he surveyed measures of community NJH. He had started at NHL, made llis key British neurologist who was a specialist on cancer prevention activities. He was also a discovery at the NIAMD, and then left the movement disorders, died Sept. 29 of a peer review administrator ... George L. Bethesda campus to cominue work on heart attack. He had just begun a one-year Payne, 83. a retired NTH liaison officer, transducti on as scientific director of NlEHS sabbatical at NCH. He was a professor of died Aug. 17 of lung cancer at his home in from 1985 co 1989, and therea fter as neurology at the National Hospital for Garrett Park. After working at the British scientist emerin1s ... Or. Arthur Saz, a Neurology and Neurosurgery in London and Embassy ( 1938-1955), Payne began bis microbi ologist and professor who was a

27 N I H A A UPDATE

leader in Lhe field of antibiotic resistance diabetes ... Rachel Stewart, 27. died Arundel Medical Center in Annapolis. As a research. died or a heart attack Nov. 17 at suddenly on Nov. I from an allergic young woman. she was a receptionist and Georgetown University Hospi1al. In 1948, reaction to food. sevcrn l weeks before her secretary at NIH. then she joined the he joined the swff at NIH and became 28th birthday and in the midst or planning Central Intelli gence Agency where she chier of the sec1ion of medical and for her wedding. She came to CSR in worked for 30 years before retiring ... Or. physiological bacteriology in the Labor.i­ August 1997. and was a grants technical Ech"in A. Weinstein, 89. a neuropsychia­ tory of Infectious Diseases. He left NTH in assistant for the integrntive. functional. and trist and author who worked on the 1964 to become chainnan of the microbi­ cognitive neuroscience initial review group interrelation hip of brain function. culture ology department at Georgetown Univer­ in the Division of Physiological Systems ... and experience. died Sept. 7 at home in si1y medical and dental school. He retired Or. Frederick L. Stone, 83, died of heart Bethesda of complications from a stroke. from that position in 1984 and joined the ailments on Oct. 19 in an Alabama hospital. He had been a guest researcher at NIA ... department of immunology where he He served as NIGMS' second director Lawrence 0. Willhite, 55. an NCI fnci lities continued his research until suffering a ( 1964-1970). He first cnme to NIH in 1948 manager. died Dec. 7 of a heart anack at his debilitating stroke in 1995 ... Dr. William as chief of the Research Fellowships home in Kensington. He had worked 26 Scl1ntten, a concert pianiM and world­ Branch at DRG. Before joining NlGMS. years in the Office of the Director of renowned Atlanta plastic surgeon. died of Stone also served in various other capacities DCBD/DBS ... Lois P. Whitley, 68. a cancer Oct. 23 at his home. Early in his at N'IH. including chief of extramural retired clinical research associate at NIH. career, he was in the surgery branch at the programs al the NINDB and assistan1 to the died Sept. 12 at Holy Cross Hospital. She CC ( 1956-1957) ... Ellen Hickey associate director of NIH. I-le left NIH in had a liver ailment. She worked at NINDS Schildkamp, 58. a former teacher who 1970 LO become president of New York ( 1967-1995) in tl1e Division of Convulsive. was an administmtive assistant (1987- Medical College. In 1978 he became Developmental, & Neuromuscular 1997) in the Office or the Director. died of consultant to the Universi ty of Alabama at Disorders in the Epilepsy Branch ... Or. melanoma Jan. 8 at Suburban Hospital ... Binningham ... Or. Robert Church Charles Gordon Zubrod, 84. a retired NCI Or. Sam Silbergeld, 80, a psychiatrist and Stroud, 80. a phy!.iologist and retired NIH physician who wa.~ a pioneer in the use of biochemist. died of renal failure Jan. 3 at a administrator. died of cardiac arrest Aug. 13 chemotherapy. died of respiratory failure nursing home in Seaule. He first joined at the Carriage Hill Nursing Home. He Jan. 19 at Sibley Memorial Hospitnl. He NIH in the Division of Biologics Stan­ came to NTH in 1984 and worked us a had spinal meningitis and pneumonia. In dards. He was a reseurch grnntS specialist training grnnts and awards branch chief and 1954. he moved 1.0 the Washington area and who then compl eted a psychiatry residency health sciences admi ni strator for NHLBl's began his NIH career. From 1954 to 1961. at Stanford University and returned to extramural affairs division before retiring in he was clinical director of NCI and from NIMH as a research psychiatrist. He was the late 1980's. His research specialty w;L\ 1961 to 1974. he wa.~ scientific director of chief of the biopsychosocial clinical safe working conditions in deep waters. He NCI. At NCI. he began using drug!> to treat research section. which included bio­ was working on a manuscript related to the cancer. starting wi th acute leukemia in chemical correlat~ of i.trcss. When he concept of time ... George W. Summers, children. TI1e t.rcmment was successful and retired from the PHS in 1987 he was 78. a fom1er administrati ve and contract it led to establishment of chemotherapy as a ad 111inis1ra1or of the geriatric program at specialist at NHI , CC and NCI (1955- 1985) standard treatment for cancer. In 1972, he S1. Eliwbeths Hospital. After he retired, died Sept. 26 at his home in Kensington. received the Lasker Award for his work. He he was a psychiatrist at Sheppard Pruu Md ... Or. Norman 'lhmarkin, 60. a left NIH in 1974 to become director of the ln~titute in Baltimore and taught at the psychiatrist in tl1e Washington area, died of Florida Comprehensive Cancer Treatment University or Maryland and the Unifonncd respiratory distl"CliS syndrome Jan. 7 at a Cemer in Miami. In 1990. he retired and Services University ... Or. Neilson F. hospital in Philadelphia. He had been returned to the Wa~hington area. Smith, 68. a social worker who retired in irtjured in a ~wimm ing pool accident in 1993 as chief of the soc ial work training June and was h o~ pitalizcd since the branch at NIMH. died of sepsis and renal accident. Before setti ng up his own failure Sept. 9 at a hospital in Pittsburgh. practice. he did research at NIMH in the In 1996. he had received a lung transplant mid-1960's ... Or. William H. TulJner died at the University of Pinsburgh Medical on Nov. 20 in Bccsleys Point, N.J. In 1946, The NIHAA received a Center and he was being treated for a he joined IH and retired in 1973. He wru, contribution from bacterial infection when he died. He chief of the section on Endocrinology. Mn.. Mary Calley Hartman began working at NIMH in 1968 as a Reproduction R~earch Branch. NlCHD. in memory of Louise Anderson. social work program specialist in the He retired to Beesleys Point in 1979 where Capt. William Briner. 1 educaLion branch and bccnmc chief of thnt he was able to contin ue his love of the Mildred Ooughcrt) • branch and also served as a li aison outdoors through birding and 01her Margaret Haller Little. between schools of social work and naturalist activities ... Ervin E. Uttcrmann, Ann Marston. nnd Evelyn Miller. federal training progmms ... Peter James 78. a retired NIH employee who worked at Stathis, 76, a property utiliwtion NIH (1965-1983). died Aug. 22. He worked specialist at NIH (1963-1993). died of as a budget analyM in the Division of liver failure Oct. 18 at Holy Cross Financial Management, OD ... Carol Joan Hospital. He al. o had a heart ai lment and Vucci, 65. died of cancer Sept. 30 at Anne

28 SPRING 1 9 9 9

BALLOT NATIONAL INSTITUTES OF HEALTH ALUMNI ASSOCIATION

PLEASE TEAR OUT AND RETURN WITH YOUR VOTE I

In accordance with the bylaws of the NIHAA, alumni members of the association are to elect one-third of the board of the association. The nominating committee, appointed by President William S. Jordan, Jr., has nominated the alumni members listed below, each of whom has agreed to serve on the board of directors if elected, or to occupy positions on the board left open by expiring terms of office of present members. Each alumnus( a) member may vote for four (4) oftbese nominees. Please note that associate members (current NIH employees) are not eligible to vote in this election. NOMINEES FOR BOARD OF DIRECTORS

Please vote for up to four (4) and return your ballot to the NIHAA office by MAY 1.

Nominees Former Nill Affiliation D Mr. Alexander Adler DRG, NIH Record founding editor D Dr. Artrice Bader NCI, NJGMS scientist D Dr. John T. Bartko NIMH statistician D Dr. Edwin Becker NIDDK scientist D Dr. Robert Berger NHLBI scientist D Dr. William Blot NCI epidemiologist D Dr. Cyrus R. Creveling NIDDK scientist D Dr. Vic M. Exposito DBS scientist D Dr. Joseph Handler NHLBI scientist D Dr. Samuel S. Herman NEI, NCI, NIEHS scientist/administrator D Ms. Jane Sundelof Jones OD personnel D Dr. Lloyd Law* NCI scientist D Dr. Car l Leventhal NINDB, NCI, NIAMD, NIDDK, OD scientist/administrator D Dr. Lois Lipsett* NIDDK administrator D Dr. Kathleen McCormick NIA sc.ientist D Dr. Gregory O'Conor NCI scientist D Dr. Morris Parloff NIMH scientist D Dr. Karl Piez NIDR scientist * CURRENT BOARD MEMBERS WHO ARE ELIGIBLE FOR A SECOND TERM. SPRING 1 g g g

NIH Retrospectives Commission spoke to NIH employ­ ees on the development of a bikeway f~1Record system for NIH and the surrounding -~ - ·~- - ':....- _.. .. :..: _.. __ _..... area. Spring 1979

Ri sing gasoline prices and the initiation of parking fees at Nl.H have spurred TheNHRecord Spring 1959 NIH employees to find alternative ways - of getting to work. Employees have Spring 1989 The NIN Record has changed its turned to the bicycle as a way to beat format: more news, a special science U1e additional expense to save on Construction on the 32.000-square-foot section. larger size, bigger type and a energy, and Lo improve their health. Children's Inn is slated for completion. new masthead. The first issue of the Recently NTH director Dr. Donald The inn is a home away from home for Record came off the press on May 20, Fredrickson, Montgomery County pediaa·ic patients ... Dr. James 8. 1949. [Happy 50th Ann iversary. Jn transportation officials and representa­ Wyngaarden, NIH director since 1982. 1949, the employee population of tives of the Maryland-National Park announced his resignation on Apr. 20. NIH was 2,200. In 1959. the number of increased to 7,600. Now there arc over 17.000 employ~ al NIH] ... NlH has selected a 513-acre site for a pem1anent animal farm. ft is 25 miles from Bethesda, three miles southwest of PoolesvilJe, Md.

Spring 1969

Dr. Jack Masur, di rector of the Clini cal Center, died suddenly of a heart attack on Mar. 8. He had been closely associated with the CC since its beginning; he also served as N[H associate director for clinical care administration and held the rank of assistant surgeon general in the PHS. Dr. Robcn M. Farrier has been ap­ pointed acting director ... King Baudouin and Queen Fabiola of Belgium visited NIH and toured the campus and CC facilities ... The first Dr. Donald Fredrickson starts out for his noon-hour rid e after taking his bicycle from the bike rack near National Advisory Eye Council of the his offi ce (Dr. Varmus is not th e first NIH director to newly established National Eye use his bike as a mode of transportation.) Institute has been announced by Dr. Roben Q. Marston. NfH director.

31