A Transgenic Probiotic Secreting a Parasite Immunomodulator for Site-Directed Treatment of Gut Inflammation
© The American Society of Gene & Cell Therapy original article original article Transgenic Probiotic Inhibits Gut Inflammation © The American Society of Gene & Cell Therapy A Transgenic Probiotic Secreting a Parasite Immunomodulator for Site-Directed Treatment of Gut Inflammation Rose A Whelan1, Sebastian Rausch1, Friederike Ebner1, Dorothee Günzel2, Jan F Richter2,3, Nina A Hering4, Jörg-Dieter Schulzke4, Anja A Kühl5, Ahmed Keles2, Pawel Janczyk6, Karsten Nöckler6, Lothar H Wieler7 and Susanne Hartmann1 1Center for Infection Medicine, Institute of Immunology, Freie Universität Berlin, Berlin, Germany; 2Institute of Clinical Physiology, Charité- University Medicine Berlin, Berlin, Germany; 3Current address: Institute for Anatomy II, Friedrich-Schiller-University, Jena, Germany; 4Department of Gastroenterology, Division of Nutritional Medicine, Charité-University Medicine Berlin, Berlin, Germany; 5Department of Internal Medicine, Rheumatology and Clinical Immunology/Research Center ImmunoSciences (RCIS), Charité-University Medicine Berlin, Berlin, Germany; 6Unit for Molecular Diagnostics, Genetics and Pathogen Characterisation, Department of Biological Safety Federal Institute for Risk Assessment, Berlin, Germany; 7Institute for Microbiology and Animal Health, Department of Veterinary Medicine, Freie Universität Berlin, Berlin, Germany New treatment strategies for inflammatory bowel disease INTRODUCTION are needed and parasitic nematode infections or appli- Parasitic worms modulate host immune responses in order to cation of helminth
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