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Data Is Driving the Future of Neurotechnology with Cranialcloud Nexeon MedSystems DATA IS DRIVING THE FUTURE OF NEUROTECHNOLOGY WITH CRANIALCLOUD Will Rosellini, Chairman and Chief Executive Officer, Nexeon Medsystems, and Pierre-Francois D’Haese, PhD, Founder and Chief Executive Officer, Neurotargeting, discuss the neurotechnology market and how the Internet of Medical Things is creating exciting opportunities in the space. Looking at the collaboration centring Nexeon’s Deep Brain Stiumulation technology and Neurotargeting’s CrainialCloud, they expand on the untapped potential in the sector and how it might be realised by a platform type business model. INTRODUCTION “Successful usage of IoMT The past decade has ushered in Mr Will Rosellini Chairman and CEO an explosion of neurotechnology will require a vast and layered T: +1 214 414 0454 designed to measure, improve and database of neurological E: [email protected] repair nervous system function in information, including real- patients suffering from chronic time neural recordings that Nexeon MedSystems, Inc diseases. Newly developed 1910 Pacific Avenue, Suite 20000 implantable neurostimulators, enable medical treatment to be Dallas wearable stimulators and imaging customised to specific patients.” TX 75201 techniques provide rich data to fuel United States further refinement of therapies. www.nexeonmed.com In parallel, a global rise in the “Quantified Self” concept has gained treatment to be customised to specific traction, enabled by Internet of Things patients. Linking nervous system recordings (IoT) technology. More recently, leaders with the IoMT facilitates the alleviation of the neurotech revolution are adopting of chronic pain, stopping of tremors or an emerging sub-sector of IoT for use in improvement of mood disorders, all at neurotechnology – the Internet of Medical the touch of a button. Once this level of Things (IoMT). connectivity is achieved, the addressable IoMT refers to a connected neurotechnology market is expected to infrastructure of medical devices and widen significantly as these therapies start software applications that can communicate to improve patient outcomes whilst also Dr Pierre-Francois D’Haese with various healthcare IT systems. IoMT reducing the overall burden of management. Founder and CEO is being leveraged to improve medical T: +1 615 835 2386 care by integrating neurological data DEEP BRAIN STIMULATION E: [email protected] with other biometric diagnostics, thus providing medical professionals with richer Deep Brain Stimulation (DBS) therapy is Neurotargeting, LLC information with which to make their one of the most common technologies that 1315 16th Ave S decisions. Successful usage of IoMT will modulates a patient’s neuronal activity. Nashville TN 37212 require a vast and layered database of Worldwide, it has been prescribed in United States neurological information, including real- over 150,000 patients with Parkinson’s time neural recordings that enable medical disease (PD), a neurodegenerative disorder www.neurotargeting.com 44 www.ondrugdelivery.com Copyright © 2017 Frederick Furness Publishing Ltd Nexeon MedSystems which leads to a progressive deterioration of motor function. DBS has also shown great potential in alleviating symptoms of patients suffering from other movement disorders. Unfortunately, evaluation of long term studies shows that neuromodulation technologies, such as DBS, have not received major improvement since arriving on the market 30 years ago. While DBS therapy does improve a patient’s quality of life, compared with other medical technologies such as pacemakers, it is in a state far removed from its potential. At present, DBS involves empirically selected stimulation parameters arrived at through trial and error over a number of clinical visits. Identification of the appropriate DBS stimulation parameters can take up to six months, followed by up to twelve months of intermittent adjustments during outpatient visits. Oftentimes the stimulation parameters are not fully optimised to maximise patient outcomes, falling short of the potential improvements a patient could receive. To date, DBS device manufacturers have yet to provide neurologists with the robust tools needed to assess a patient’s quality of life continuously and enable them to fine tune the stimulation parameters. The technology implanted for the last Figure 1: Nexeon’s synapse device. 30 years provides a static or pseudo-static stimulation scheme that does not adjust to a patient’s disease state, medication “Observing directly how the brain reacts to stimulation status or side-effects. DBS therapy will only in real-time opens the door to closed-loop control, reach its full potential once the therapeutic output adapts to a patient’s neurological refining stimulation to the true physiological state. Such state automatically. control is preferable to using manual adjustments, which Recognising this gap in the market, are time consuming, prolonged and often subjective.” Nexeon MedSystems has created a DBS device that records local field potentials (LFPs) of the neuronal activity where have enabled robust, sustained recordings of the true physiological state. Such control known biomarkers of the disease can be these LFP biomarkers. Physicians and neuro- is preferable to using manual adjustments, detected (Figure 1). These recordings can engineers are cautiously optimistic that this which are time consuming, prolonged and then be extracted, analysed and used to create never before collected data will provide often subjective. self-adjusting algorithms that automatically the basis for “closed-loop” systems that Nexeon’s vision is for neurotechnology optimise the therapy. Stimulation will be automatically adapt to a patient’s clinical to integrate with IoMT technologies that delivered and signals will be collected using state, therefore improving the efficacy of address all aspects of medical treatment a bidirectional DBS system instead of setting the therapy and minimising undesirable to maintain a comprehensive picture of static parameters that do not account for the side-effects. patient health. This means neurological numerous changes a person goes through Furthermore, as the MedTech world is data will combine with the IoMT system during the course of a day. Just as a connecting us to an ever increasing number that tracks patient medications, hospital pacemaker dynamically adjusts to keep the of wearable sensors, Nexeon is setting visits, data from wearable devices, caregiver heart at a healthy, appropriate rate, the up the path for the brain stimulator to input, patient vital signs and other key Nexeon DBS system adjusts to keep the correlate its data with external information indicators for comorbidity management brain in a healthy, optimally functioning about a patient’s state or actions in order (i.e. diabetes, COPD, dysphagia, etc). state. It will also enable physicians to to produce more sophisticated insights to The goal is not the singular treatment of, manage patients remotely to reduce or avoid how a specific disease effects a patient. for example, Parkinsonian tremor, the goal disruption to quality of life. Observing directly how the brain reacts to is complete interconnectivity on all aspects Thus far, the benefits of LFPs have stimulation in real-time opens the door to of a patient’s healthcare to improve their remained a mystery, since no DBS devices closed-loop control, refining stimulation to overall wellbeing. Copyright © 2017 Frederick Furness Publishing Ltd www.ondrugdelivery.com 45 Nexeon MedSystems Figure 2: Platform versus Linear business models. DATA-DRIVEN NEUROTECHNOLOGY PLATFORMS “CranialCloud handles the management of neurological Revolutionising neurotechnology requires diseases by collecting images of a patient’s brain and a new way of doing business. The 20th spatially relating their information to these images, century was dominated by the factory facilitating improved clinical decision making.” business model, in which companies create a commodity and push it in one direction toward the customer at the end regardless of their current size. decision making by healthcare providers. of the supply chain. Internally owned and Although a platform model enables Leveraging data on patient disease holds controlled resources are a factory’s most transactions, it does not directly control the potential to eliminate redundant or valuable assets. It is now the case that the behaviour of its users. In the context predictable decisions, saving valuable platform business models are starting to of neurotechnology, the users are patients, physician time and focusing their replace these traditional linear models by caregivers, researchers and healthcare attention on what only they can do: enabling a multi-directional exchange of providers. The challenge for neurotech diagnose, plan treatments, perform value between two or more user groups. companies going forward is directing user procedures and care for patients. With Platform businesses use external networks, behaviour toward effectively improving these tools, quality patient care can expand such as the IoMT technology, data and patient care. beyond specialised centres into more rural users, as the aggregator of business value The answer lies in the four core functions or underserved areas. Smart neurotech rather than investing in and growing their of a platform: devices, paired to data supported decision internal resources or supply chain (Figure 2). making algorithms, could support A useful analogy would be General 1. Audience building
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