Neurotechnologies and Brain Computer Interface

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Neurotechnologies and brain computer interface

Market and Technology analysis

2018 LIST OF COMPANIES MENTIONED IN THIS REPORT

240+ slides of market and technology analysis

Abbott, Ad-tech, Advanced Brain Monitoring, AdvaStim, AIST, Aleva Neurotherapeutics, Alphabet, Amazon, Ant Group, ArchiMed, Artinis Medical Systems, Atlas Neuroengineering, ATR, Beijing Pins Medical, BioSemi, Biotronik, Blackrock Microsystems, Boston Scientific, Brain products, BrainCo, Brainscope, Brainsway, Cadwell, Cambridge Neurotech, Caputron, CAS Medical Systems, CEA, Circuit Therapeutics, Cirtec Medical, Compumedics, Cortec, CVTE, Cyberonics, Deep Brain Innovations, Deymed, Dixi Medical, DSM, EaglePicher Technologies, Electrochem Solutions, electroCore, Elmotiv, Endonovo Therapeutics, EnerSys, Enteromedics, Evergreen Medical Technologies, Facebook, Flow, Foc.us, G.Tec, Galvani Bioelectronics, General Electric, Geodesic, Glaxo Smith Klein, Halo Neurosciences, Hamamatsu, Helius Medical, Technologies, Hitachi, iBand+, IBM Watson, IMEC, Integer, Integra, InteraXon, ISS, Jawbone, Kernel, LivaNova, Mag and More, Magstim, Magventure, Mainstay Medical, Med-el Elektromedizinische Geraete, Medtronic, Micro Power Electronics, Micro Systems Technologies, Micromed, Microsoft, MindMaze, Mitsar, MyBrain Technologies, Natus, NEC, Nemos, Nervana, Neurable, Neuralink, NeuroCare, NeuroElectrics, NeuroLutions, NeuroMetrix, Neuronetics, Neuronetics, Neuronexus, Neuropace, Neuros Medical, Neuroscan, NeuroSigma, NeuroSky, Neurosoft, Neurostar, Neurowave, Nevro, Nexeon, Nexstim, Nielsen, Nihon Kohden, Nirox, Nonin Medical, Nuvectra, Olympus, Ornim, Oscor, Pacesetter, Panasonic, Paradromics, Philips, Plexon, PMT Corporation, RetroSense, Rhythm, Ripple, Rythm Dreem, Samsung, SceneRay, Second Sight Medical, Sensomedical, Setpoint Medical, Shimadzu, Siemens, Sony, Sorin Group, Soterix Medical, SPR Therapeutics, Stim Wave, Teijin, Thync, Toyota, Verily, VieLight, Vygon, Ximedica, Ybrain,

And many more !!

Information gathered through direct discussions with technology developers, end-users and key opinion leaders

Jérôme Mouly Jerôme Mouly serves as a Technology & Market Analyst specialized in microtechnologies for biomedical & medical imaging applications at Yole Développement (Yole). Since 2000, Jérôme has participated in more than 100 marketing and technological analyses for industrial groups, start-ups and institutes related to semiconductor & medical technologies industry. Jérôme holds a Master of Physics from the University of Lyon.

Dr. Marjorie Villien As a Technology & Market Analyst, Dr. Marjorie Villien is member of the Medical Technologies business unit at Yole Développement (Yole). She is a daily contributor to the development of these activities with a dedicated collection of market & technology reports as well as custom consulting projects. After spending two years at Harvard and prior Yole, Marjorie served as a research scientist at INSERM. Marjorie Villien is graduated from Grenoble INP and holds a PhD in physics & medical imaging.

KnowMade’s team realized the patent analysis:

Dr Coralie Le Greneur Dr Coralie Le Greneur works for Knowmade in the field of Biotechnology and Life Sciences. She holds a PhD in Molecular Biology from the University of Nice Sophia- Antipolis (France). She also holds the International Industrial Studies Diploma in Patents from the CEIPI, Strasbourg (France).

Dr. Brice Sagot Dr. Brice Sagot is COO and cofounder of Knowmade. He is leading the Biotechnology and Life Sciences department. He holds a PhD in molecular biology from the University of Nice Sophia-Antipolis, France.

3 OBJECTIVES OF THIS REPORT

• Explain the challenges linked to neurotechnologies, and their current/ future applications

• Offer a technical and economic segmentation of the neurotechnologies field: neurosensing, neurostimulation, and brain computer interface (BCI)

• Deliver an overview of neurotechnologies’ main players and their respective technologies

• Furnish market data and forecasts for the period 2017 - 2035, and market dynamics for each segment

• Provide neurotechnology roadmaps and an overview of the latest innovations in each segment

• Understand the most active companies through a comprehensive patents list for neurostimulation and neurosensing

4 WHO SHOULD BE INTERESTED BY THIS REPORT?

o Pharmaceutical and medical device companies: o Medical devices outsourcing companies: • To understand what is state of the art in • To have a broad overview of all neurotechnology neurotechnology applications & markets • To identify the different players across the supply • chain To identify new markets • To get a list of selected players in the field of • To monitor and benchmark potential neurotechnology both in the market and in competitors development • To understand behavior evolution • To understand behavior evolution and identify • To identify the key challenges linked to hardware new business models in the field of neurotechnology • To identify competitors and targets for collaborations or M&A o Financial & Strategic investors: o Equipment & Material suppliers: • To understand the potential for neurotechnology • To understand the technical evolution of devices in the consumer and healthcare neurotechnology devices. industries • To identify business opportunities and prospects • To know the latest trends within the industry • To get a list of players in the field of o R&D players: neurotechnology and their activities • To understand new challenges in neurotechnology

5 TABLE OF CONTENTS

• Executive Summary 10 • Patent landscape by KnowMade • Company profiles • Introduction 55 • How does the brain work? • Neurostimulation 153 • Neurological disorders • Main players and market share • Brain Initiative • Market data and forecasts 2017 – 2023 by technology (DBS, SCS, VNS, TMS, • Scope of the report TDCS, etc.) and by application (clinical, research, consumer) • Main technologies and roadmaps • Segmentation of the Neurotechnology Market 67 • Patent landscape by KnowMade • Technological and behavioral/economical criteria • Company profiles • Segmentation • Brain Computer Interface 204 • Market Analysis 71 • Main players • Mergers and acquisitions • Market data and forecasts 2017 – 2023 by applications • Fundraising analysis • Main technologies and roadmaps • Market data and forecasts 2017-2023 • Company profiles • Neurotechnology ecosystems • IOMT in the neurotechnology business • Supply Chain Analysis 227 • Roadmaps • General Conclusions 233 • Forecasts 2017-2035 using the model of the DNA sequencing history • Annex - Patent Landscape Methodology 238 • Neurosensing 90 • Main players and market share • Market data and forecasts 2017 – 2023: system level and electrodes level, by technology and by application • EEG value chain • Main technologies and roadmaps

6 INTRODUCTION TO NEUROTECHNOLOGY How does the brain work? (1/2)

• The brain is made of a lot of different types of cells: • Neurons : electrically excitable cells that receive, process, and transmit information through electrical and chemical signals • Microglia : immune system • Oligodendrocytes : provide support and insulation to axons • Astrocytes : variety of tasks, from axon guidance and synaptic support, to the Most of the control of the blood brain barrier and blood flow technologies aiming at interacting with • The axon of the neuron is responsible for conveying an action potential from the brain target the cell body to the axon terminus. An action potential is an electrical signal the electrical resulting from a sudden, transient change in membrane potential. signaling pathway of the neurons

7 INTRODUCTION TO NEUROTECHNOLOGY How does the brain work? (2/2)

• When an action potential reaches an axon terminal it triggers the release of neurotransmitters into the synaptic cleft which diffuses and binds receptors on the postsynaptic neuron. • Sufficient binding will cause the postsynaptic neuron to “fire”. • There are two kinds of neurotransmitters : • Excitatory neurotransmitters stimulate the brain. Electrical events propagate the • Inhibitory neurotransmitters calm the brain and help create balance. signal within a neuron and chemical processes transmit the signal from one neuron to another

8 INTRODUCTION TO NEUROTECHNOLOGY Neurological disorders

Worldwide prevalence of most neurological disorders (in millions people affected)

100 350M 1,140M 90 80 70 Up to 1 billion 60 people, nearly 50 one in six of 40 30 the world's 20 population, 10 suffer from Millions peopleaffected - neurological disorders

Non- Source: WHO Psychiatric Trauma Infections Degeneration Tumors Vascular psychiatric disorders disorders

9 INTRODUCTION TO NEUROTECHNOLOGY Scope of the report

Included in this report are neurotechnologies Not included in the scope of this report are which directly interact with/touch the patient, neurotechnologies based on medical imaging such as neurosensing technologies (EEG, ECoG, systems not directly interacting with the patient NIRS, etc.), neurostimulation (DBS, VNS, TDCS, (MRI, MEG, PET, etc.), cochlear implants and etc.) and brain computer interfaces. retinal prosthesis. Scope: Neurotechnologies directly interacting with patients

10 SEGMENTATION OF THE NEUROTECHNOLOGY MARKET

Technological Invasive Non invasive Invasive Non invasive Invasiveness Behavioral criteria criteria Electrical Light Magnetic Ultrasound Technology Electro-corticography, Electro- Near infrared Sensing Neural probes encephalography spectroscopy Transcranial Focused Clinical Neurostimulation Optogenetics magnetic ultrasounds stimulation Near Infrared stimulation Stimulation Transcranial direct current stimulations Consumer Vagus nerve stimulation Clinical Actuation Brain computer interface Consumer

Segment 1 : Neurosensing Users system Segment 2 : Neurostimulation Aim of the Aim of Segment 3 : Brain Computer Interface

: Technologies not available in clinics yet 11 NEUROTECHNOLOGY ECOSYSTEM Neurosensing