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GROWTH PHARMA BRENT SAUNDERS Chief Executive Officer and President Customer Intimacy Is Critical PATIENTS

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GROWTH PHARMA BRENT SAUNDERS Chief Executive Officer and President Customer Intimacy Is Critical PATIENTS GROWTH PHARMA BRENT SAUNDERS Chief Executive Officer and President Customer Intimacy is Critical PATIENTS Therapeutic Area Private Leader Companies Venture Capital Development Powerhouse Private Equity Commercial Machine CUSTOMER IDEAS Regional Business Players Development Start-Ups Customer Intimacy & Therapeutic Area Leadership Drive Commercial Success 2015 revenue1 Sales ($B) Ranking Top Brands Eye Care $3.0 2 global position in Alzheimer’s CNS $2.7 1 #3 global position Dermatology & global position Aesthetics $2.1 1 global position GI $1.2 3 #2 in anti-inflammatories in US Women’s Health $1.0 1 Plan to double presence by 2020 Urology $0.4 6 global position US leadership position Anti-infective $0.2 1 2 new breakthrough product launches SOURCE: Evaluate 1 Excludes generics; Botox sales allocated by TA/Indication into Dermatology & Aesthetics, CNS, and Urology A New Pharmaceutical Innovation Ecosystem Fueled by Significant Investments 6.5 3,500 6.0 5.4 3,000 4.9 Sustainability: 2,500 4.3 • Continued 3.8 2,000 VC funding 3.3 • Scientific 2.7 1,500 creativity Venture capital invested, $B Venture 2.2 1,000 Number of biotech startups • Professional 1.6 management 1.1 500 0.5 0 1995 2000 2005 2010 2014 SOURCE: Thomson Reuters, PitchBook database Pharma Innovation Ecosystem 1998 Source of NMEs by originator type REGIONAL BIOTECH & PHARMA 62% START-UPS Global Pharma 14% Biotech & Start-up Companies GLOBAL 24% PHARMA Regional Pharma Non-profit Academia ACADEMIA Specialty SPECIALTY Revenues of all NME-grade compounds launched in a given year cumulated for 7-8 years. Includes all innovative compounds classified as NME or BLA, excluding generics, biosimilars and NDA products (new derivatives, new formulations etc.) SOURCE: Evaluate 2014 New Pharma Innovation Ecosystem 2013 Source of NMEs by originator type 22% Global Pharma BIOTECH & 50% START-UPS Biotech & Start-up Companies REGIONAL PHARMA % GLOBAL 28 PHARMA Regional Pharma SPECIALTY Non-profit Academia Specialty ACADEMIA Evaluate Jul 20 Revenues of all NME-grade compounds launched in a given year cumulated for 7-8 years. Includes all innovative compounds classified as NME or BLA, excluding generics, biosimilars and NDA products (new derivatives, new formulations etc.) SOURCE: Evaluate 2014 14; McKinsey analysis New Pharma Innovation Ecosystem TODAY BIOTECH & START-UPS REGIONAL PHARMA SPECIALTY ACADEMIA GLOBAL PHARMA Allergan Model DISCOVERY DEVELOPMENT COMMERCIALIZATION CGRPs Bimatoprost SR Dalvance Kybella Relamoralin KYTH-105 OD-01 Linzess Combigan Abicipar XEN45 Avycaz Juvederm Botox Latisse CUSTOMER Vraylar Nebivolol Bystolic/Valsartan Rapastinel Teflaro Esmya Viberzi AGN-241660 Ozurdex Restasis X SER 120 We discover, acquire, partner and collaborate on compounds at all stages of R&D with a strong preference for validated targets or compounds with proof of concept. Allergan is a Forerunner in High Traditional Open science 1 R&D / Sales Low Low-cost Low High % pipeline externally sourced1 SOURCE: Evaluate; Capital IQ 1 Based on 2014 R&D spend/revenue and % of clinical non-generic NME, NDA, and biologic pipeline assets that are non-organic Allergan Ranks Among the Top Development Powerhouses Number of NME/BLA Average time between submission approvals 2009-2015 YTD of drug and approval (months)2 15 11 1 13 13 8 15 7 16 6 16 6 17 6 17 6 20 6 25 SOURCE: Evaluate; FDA; Press search 1 Includes new fixed-dose combinations and co-developments 2 NDA/NME approval time for assets with projected 2020 sales in Allergan-relevant TAs is Sustainable: Approximately Half of All Phase 2 & Phase 3 Programs Are in Allergan TAs TA pipeline assets in each clinical phase (%); total of ~2400 assets 827 1,026 571 Gastro-Intestinal Urology/Derm/Eye Allergan relevant TAs Systemic Anti-infectives Other TAs 33% Central Nervous System Respiratory 45% 49% Blood/CV/Endocrine Oncology & Immunomodulators Phase 1 Phase 2 Phase 3 SOURCE: Evaluate 1 Aesthetics & Derm, Eye Care, Urology, GI, Anti-infectives, CNS We Have the Profile for Partnering – A Key to We have the profile for partnering – a key to open science Speed Development Shared Powerhouse Vision Open Mindset Legal Prior Commercial Relationship Engine Executive Research Leadership Expected Manufacturing Execution SOURCE: McKinsey survey DARPin® Tripligan Dual DARPin® AMD (MMT) Ocular Urology GI AMD HTN & Glaucoma SER-120 Viberzi Anti-Infective Adult Nocturia IBS-D FPR2 DARPin® SR Agonist Dry Eye Disease AMD LiRIS Dalbavancin ABSSSI Interstitial Linzess Single Dose Pilo/Oxy Low Dose CIC 5 Mimetogen Cystitis Presbyopia Dry Eye Botox 4 Linzess Eye Premature Dalbavancin 5 Colonic Endocarditis Cyclosporine SR Bimatoprost SR Ejaculation Dry Eye Release CIC Relamorelin Glaucoma Botox Linzess Care Diabetic Dalbavancin Ganfort Indication X OIC ® Gastroparesis Osteomyelitis DARPin MDPF Bimatoprost Aztreonam / DME Submental Fat Reduct Oxymetazoline Avycaz Avibactam 17 Setipiprant Rosacea cUTI, cIAI Gram Neg Infect Brimo DDS Restasis Androgenic Alopecia Atrophic AMD MDPF Aczone Combo Aczone Reform Acne Vulgaris Acne Vulgaris Androgen Omega 3 OTC Evaporative Dry Eye Skin Quattro Device Women’s Health Dry Eye Delivery for Sarecycline Cortisol Analog OCU Tearbud 1 Facial Fillers Acne Dry Eye Disease Dry Eye Etonogestral Ring Ulipristal HA Threads Contraception Fibroids Forehead & Neck Juvederm Global Nasal Other Labial Folds Estradiol 4 Estradiol Vag Caps VVA Vaginal Cream VVA (Biosimilars, Cardiovascular MT10109L Aesthetics & Vobella & Dyspareunia & Dyspareunia Aesthetics Lips Fine Lines and other) Facial Lines Nebivilol/ Dermatology Rapastinel Biosimilar X Valsartan Bimatoprost Botox MDD Indication X Hypertension Androgenic Forehead Alopecia Lines Vraylar Botox Bipolar Depression MDD Bevacizumab 21 Botox Multiple Oxybutynin Volift Multiple Cancer Nasolabial Folds 9 Hyperhidrosis Botox X Ubrogepant Spasticity Acute Cetuximab Trastuzumab Migraine Multiple Multiple Phoenix Voluma Global CNS Cancer Cancer Breast Augmentation Malar Augmentation AGN-241689 Semprana Rituximab TRV-027 Migraine Non-Hodgkin Acute Heart Failure VoLite Voluma Plus Prophylaxis 9 Acute Migraine Filler Facial Volumes Lymphoma Armour Thyroid Voluma Voluma Hypothyroidism Filler for Chin Filler for Temple AGN-241660 Vraylar MDD Multiple DAVID NICHOLSON Executive Vice President, Brand R&D DARPin® Tripligan Dual DARPin® AMD (MMT) Ocular Urology GI AMD HTN & Glaucoma SER-120 Viberzi Anti-Infective Adult Nocturia IBS-D FPR2 DARPin® SR Agonist Dry Eye Disease AMD LiRIS Dalbavancin ABSSSI Interstitial Linzess Single Dose Pilo/Oxy Low Dose CIC 5 Mimetogen Cystitis Presbyopia Dry Eye Botox 4 Linzess Eye Premature Dalbavancin 5 Colonic Endocarditis Cyclosporine SR Bimatoprost SR Ejaculation Dry Eye Release CIC Relamorelin Glaucoma Botox Linzess Care Diabetic Dalbavancin Ganfort Indication X OIC ® Gastroparesis Osteomyelitis DARPin MDPF Bimatoprost Aztreonam / DME Submental Fat Reduct Oxymetazoline Avycaz Avibactam 17 Setipiprant Rosacea cUTI, cIAI Gram Neg Infect Brimo DDS Restasis Androgenic Alopecia Atrophic AMD MDPF Aczone Combo Aczone Reform Acne Vulgaris Acne Vulgaris Androgen Omega 3 OTC Evaporative Dry Eye Skin Quattro Device Women’s Health Dry Eye Delivery for Sarecycline Cortisol Analog OCU Tearbud 1 Facial Fillers Acne Dry Eye Disease Dry Eye Etonogestral Ring Ulipristal HA Threads Contraception Fibroids Forehead & Neck Juvederm Global Nasal Other Labial Folds Estradiol 4 Estradiol Vag Caps VVA Vaginal Cream VVA (Biosimilars, Cardiovascular MT10109L Aesthetics & Vobella & Dyspareunia & Dyspareunia Aesthetics Lips Fine Lines and other) Facial Lines Nebivilol/ Dermatology Rapastinel Biosimilar X Valsartan Bimatoprost Botox MDD Indication X Hypertension Androgenic Forehead Alopecia Lines Vraylar Botox Bipolar Depression MDD Bevacizumab 21 Botox Multiple Oxybutynin Volift Multiple Cancer Nasolabial Folds 9 Hyperhidrosis Botox X Ubrogepant Spasticity Acute Cetuximab Trastuzumab Migraine Multiple Multiple Phoenix Voluma Global CNS Cancer Cancer Breast Augmentation Malar Augmentation AGN-241689 Semprana Rituximab TRV-027 Migraine Non-Hodgkin Acute Heart Failure VoLite Voluma Plus Prophylaxis 9 Acute Migraine Filler Facial Volumes Lymphoma Armour Thyroid Voluma Voluma Hypothyroidism Filler for Chin Filler for Temple AGN-241660 Vraylar MDD Multiple DARPin® Tripligan Dual DARPin AMD (MMT) Ocular Urology GI AMD HTN & Glaucoma SER-120 Viberzi Anti-Infective Adult Nocturia IBS-D FPR2 DARPin Agonist Dry Eye Disease AMD LiRIS Dalbavancin ABSSSI Interstitial Linzess Single D Pilo/Oxy Low Dose CIC 5 Mimetogen Cystitis Presbyopia Dry Eye Botox 4 Linzess Eye Premature Dalbavancin 5 Colonic Endocarditis Cyclosporine SR Bimatoprost SR Ejaculation Dry Eye Release CIC Relamorelin Glaucoma Botox Linzess Care Diabetic Dalbavancin Ganfort Indication X OIC ® Gastroparesis Osteomyelitis DARPin MDPF Bimatoprost Aztreonam / DME Submental Fat Reduct Oxymetazoline Avycaz Avibactam 17 Setipiprant Rosacea cUTI, cIAI Gram Neg I Brimo DDS Restasis Androgenic Alopecia Atrophic AMD MDPF Aczone Combo Aczone Reform Acne Vulgaris Acne Vulgaris Androgen Omega 3 OTC Evaporative Dry Eye Skin Quattro Device Women’s Health Dry Eye Delivery for Sarecycline Cortisol Analog OCU Tearbud 1 Facial Acne Dry Eye Disease Dry Eye Etonogestral Ring Ulipristal HA Threads Contraception Fibroids Forehead & Neck Juvederm Global Nasal Other Labial F Estradiol 4 Estradiol Vag Caps VVA Vaginal Cream VVA (Biosimilars, Cardiovascular MT10109L Aesthetics & Vobella & Dyspareunia & Dyspareunia Aesthetics Lips Fine L and other) Facial Lines Nebivilol/ Dermatology Rapastinel
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