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Dry Eye Disease in the 21St Century the Burden of Dry Eye Disease

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Dry Eye Disease in the 21St Century the Burden of Dry Eye Disease CME MONOGRAPH Two ways to request CME credit: Visit http://tinyurl.com/dryeyedisease or fax the completed form to 215-825-4732. IMproVIng rECognITIon anD ManagEMEnT of DRY EYE DISEASE IN THE 21ST CENTURY THE BURDEN OF DRY EYE DISEASE Original Release: September 1, 2016 Last Review: August 1, 2016 Expiration: September 30, 2017 FACULTY This continuing medical education activity is jointly provided by Stephen C. Pflugfelder, MD Wills Eye Hospital and MedEdicus LLC. Chair/Moderator Esen Akpek, MD Edward J. Holland, MD America’s First World’s Best Jodi Luchs, MD This continuing medical education activity is supported through an unrestricted educational grant from Shire. Victor L. Perez, MD Distributed with Purpose and Target Audience 3. Describe their role. Increasing knowledge about dry eye disease is fueling 4. no relevant financial relationships. advances in diagnostic techniques and therapeutic Disclosures modalities that may help to overcome existing problems with underrecognition and undertreatment CME Reviewer: Ralph C. Eagle Jr, MD, has no of this common disorder. The purpose of this activity relevant financial relationships with any commercial FACULTY is to update ophthalmologists on developments in interests. the understanding of dry eye immunopathology, Faculty: evaluation, and management to enable optimal Dr Esen Akpek is a consultant for novartis ag and Stephen C. Pflugfelder, MD patient care based on improved diagnosis and Shire; and a contracted researcher for allergan. treatment tailored to the individual’s disease Chair/Moderator characteristics. Dr Edward J. Holland is a consultant for alcon; professor of ophthalmology Bausch & Lomb Incorporated; Kala pharmaceuticals; This activity is intended to educate James and Margaret Elkins Chair Mati Therapeutics, Inc; prn, Inc; rapid pathogen ophthalmologists. Screening, Inc; Senju pharmaceutical Co, Ltd; Shire; Baylor College of Medicine Designation Statement TearLab Corporation; and TearScience; receives fees Houston, Texas Wills Eye Hospital designates this enduring material from alcon; Bausch & Lomb Incorporated; Senju for a maximum of 2.0 AMA PRA Category 1 Credits ™. pharmaceutical Co, Ltd; and TearScience; a Esen Akpek, MD physicians should claim only the credit contracted researcher for alcon; Mati Therapeutics, professor of ophthalmology commensurate with the extent of their participation Inc; prn, Inc; and Senju pharmaceutical Co, Ltd; and Wilmer Eye Institute in the activity. receives other funding (travel) from alcon; and Bausch & Lomb Incorporated. Johns Hopkins University Accreditation Dr Jodi Luchs is a consultant for allergan; Bausch & School of Medicine This activity has been planned and implemented in Baltimore, Maryland accordance with the accreditation requirements and Lomb Incorporated; Shire; and TearLab Corporation; policies of the accreditation Council for Continuing receives fees from allergan; Bausch & Lomb Medical Education (aCCME) through the joint Incorporated; Shire; and TearLab Corporation; a Edward J. Holland, MD contracted researcher for aerie pharmaceuticals, professor of ophthalmology providership of Wills Eye Hospital and MedEdicus LLC. Wills Eye Hospital is accredited by the aCCME to Inc; alcon; allergan; auven Therapeutics; Bausch & University of Cincinnati provide continuing medical education for physicians. Lomb Incorporated; Eleven Biotherapeutics; and Director, Cornea Services Shire; and has ownership interest in Calhoun Vision, Instructions & Registration Cincinnati Eye Institute Inc; CXL ophthalmics; Insightful Solutions, LLC; This course takes approximately 2.0 hours. please omega ophthalmics; rapid pathogen Screening, Cincinnati, ohio read the monograph, consulting any additional Inc; and Strathspey Crown. references if needed. once the materials have been Dr Victor L. Perez is a consultant for Bausch & Lomb Jodi Luchs, MD reviewed, complete the post test and evaluation Incorporated; parion Sciences; and Shire; receives found at the end of monograph and fax to 215-825- assistant professor of ophthalmology intellectual property rights/is a patent holder of 4732 or go to http://tinyurl.com/dryeyedisease to and Visual Sciences nanovax; and has ownership interest in Eyegate. albert Einstein College of Medicine take a post test and course evaluation, after which you will be able to generate your CME certificate. Dr Stephen C. Pflugfelder is a consultant for Bronx, new York allergan and Shire; and a contracted researcher for Learning Objectives partner allergan. Director, Cornea/External Diseases Upon completion of this activity, ophthalmologists should be able to: Planning Committee: The faculty have relevant Director, Clinical research • Evaluate, diagnose, and rate the severity of commercial relationships as described above. South Shore Eye Care dry eye disease Cheryl Guttman Krader, PhD; Diane McArdle, PhD; Wantagh, new York • Describe the implications of inflammation in Cynthia Tornallyay, RD, MBA, CHCP; and Wills Eye dry eye disease on diagnosis and treatment Hospital Staff and Advisory Board have no real or Victor L. Perez, MD approaches apparent financial relationships with any commercial professor of ophthalmology • Select an appropriate treatment regimen for interests. Director, ocular Surface Center dry eye disease based on individual patient Commercial Support Bascom palmer Eye Institute characteristics This activity is supported through an unrestricted Miller School of Medicine Hardware & Software Requirements—Digital Edition educational grant from Shire. University of Miami High-speed Internet connection Special Services Miami, florida (Broadband, Cable, or DSL) If you need special accommodations because Windows 2000 or higher of a disability or for an alternative form of 256 MBs or more of raM course materials, please contact us at CME REVIEWER Internet Explorer 6.0 or higher [email protected] or (215) 440-3168. Windows Media player 10.0 or higher Wills Eye Hospital fully complies with the legal requirements of the americans with Disabilities act adobe acrobat 7.0 or higher Ralph C. Eagle Jr, MD and the rules and regulations thereof. professor of ophthalmology Course content compatible with Mac oS Provider Contact Information Disclosure Sidney Kimmel Medical College for questions about the CME activity content, as a provider accredited by the aCCME, Wills Eye Thomas Jefferson University please contact Wills Eye Hospital at Hospital must ensure balance, independence, Director, Department of pathology [email protected] or objectivity, and scientific rigor in all its sponsored (215) 440-3168. Wills Eye Hospital educational activities. all faculty participating in this philadelphia, pennsylvania CME activity were asked to disclose the following: Privacy Policy 1. names of proprietary entities producing health all information provided by course participants is care goods or services—with the exemption of confidential and will not be shared with any other nonprofit or government organizations and non– parties for any reason without permission. health-related companies—with which they or Disclaimer their spouse/partner have, or have had, a The views and opinions expressed in this relevant financial relationship with in the past educational activity are those of the faculty and do 12 months. for this purpose, we consider the not necessarily represent the views of Wills Eye relevant financial relationships of a spouse/ Hospital, MedEdicus LLC, Shire, EyeNet , or american partner of which they are aware to be their academy of ophthalmology. financial relationships. 2. Describe what they or their spouse/partner Copyright received (eg, salary, honorarium). ©2016 MedEdicus LLC SPONSORED SUPPLEMENT 2 IMproVIng rECognITIon anD ManagEMEnT of DRY EYE DISEASE IN THE 21ST CENTURY THE BURDEN OF DRY EYE DISEASE Dry eye disease (DED) is a common and important problem. Bothersome ocular discomfort symptoms are generally what According to estimates of various studies and depending on brings patients with DED to seek care, and therefore symptom the criteria used to define the disease and the population, the assessment should be the first step in the diagnostic prevalence of DED may be as high as 33%. 1 Importantly, there evaluation. patients with DED also commonly report difficulty is good evidence showing that DED can have a considerable with visually challenging tasks, including computer use, reading, and driving. 3 although a variety of validated negative effect, adversely affecting visual, social, and physical questionnaires and other surveys designed to assess ocular functioning, along with workplace productivity and quality discomfort–related issues, visual difficulty, and effect on quality 1-3 of life. of life as an initial screen are available, clinicians can simply ask patients whether or not their eyes feel dry and/or The market of therapies for dry eye has been exploding. Sales of uncomfortable, and if so, what effect it has on their activities. products for the treatment of DED approached $3.2 billion in 2015 and are expected to reach $4.5 billion by 2020, driven in Conventional clinical tests used for diagnosing DED include the part by advances in diagnosis and treatment that stem from Schirmer test with or without anesthesia, tear film break-up improved understanding of DED types and pathophysiology. 4 time (TBUT) using fluorescein, conjunctival lissamine green staining, and corneal fluorescein staining. These assessments, This CME monograph provides an update on DED however, are most useful for identifying patients
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