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55th ASMS Conference on Mass Spectrometry Page 19S Lam2; Zhibo Yang1; Julia Laskin1; 1Pacific Northwest WOG pm 03:30 Molecular Characterization and Reactivity of National Laboratory, Richland, WA; 2The University Dissolved Organic Matter along a River to Ocean of Hong Kong, Hong Kong, China Transect by High Resolution Electrospray WOE pm 03:50 Dissociations of β-Alanine Radicals following Ionization FT-ICR-MS; Rachel L. Sleighter; Susan Femtosecond Electron Transfer; Frantisek Turecek; A. Hatcher; Patrick G. Hatcher; Old Dominion University of Washington, Seattle, WA University, Norfolk, VA WOE pm 04:10 Sources of Variation in VUV Photofragmentation WOG pm 03:50 Nano-electrospray Ion Mobility Separations On- Studies of Peptide Ions; Matthew S. Thompson; Line with Inductively Coupled Plasma Mass James P. Reilly; Indiana University, Bloomington, IN Spectrometry for Detecting Metal-Containing Biomolecules (8 kDa to 80 MDa); Spiros Pergantis; 2:30 - 4:30 PM University of Crete, Heraklion, Greece NOVEL MS INSTRUMENTATION WOG pm 04:10 Coupling of an Atmospheric-Pressure Glow Chair: Steve Lammert Discharge to a Mattauch-Herzog Mass WOF pm 02:30 Utilizing an Electrospray Membrane Probe to Spectrograph with Faraday-Strip Array Multichannel Detection; Gregory D. Schilling1; Explore Fundamental Mechanisms underlying 1 1 Electrospray Ionization in Mass Spectrometry; Francisco J. Andrade ; Steven J. Ray ; Roger P. Sperline2; M. Bonner Denton2; Charles J. Barinaga3; Craig M. Whitehouse; Thomas P. White; Analytica of 3 1 1 Branford, Inc., Branford, CT David W. Koppenaal ; Gary M. Hieftje ; Indiana University, Bloomington, IN; 2University of Arizona, WOF pm 02:50 A Gas Ion Separator for Improved Collection of 3 Ions Desorbed from Surfaces at Ambient Pressure; Tucson, AZ; Pacific Northwest National Laboratory, Brian Musselman; Joseph Tice; Elizabeth Crawford; Richland, WA Douglas Simmons; IonSense, Inc., Saugus, MA WOF pm 03:10 Structure and Performance of PCB Ion Trap Mass 4:45 – 5:30 pm Spectrometer(PCBITMS); Gong-Yu Jiang1; Xiao- AWARD LECTURE Xu Li1; An Hu1; Chan Luo1; Peng Yang1; Xian-Nian Recipient of the Biemann Medal Liu1; Zi-Guo Dai1; Fu-Xing Xu1; Li Ding2; Chuan- Fan Ding1; 1Chemistry Dept., Fudan University, 5:30 – 6:00 pm China, Shanghai, China; 2Shimadzu Research ASMS BUSINESS MEETING Laboratory (Europe), Manchester, United Kingdom WOF pm 03:30 The Halo Ion Trap Mass Analyzer; Daniel E. Austin1; Miao Wang1; Samuel E. Tolley2; Aaron R. THURSDAY MORNING, JUNE 7 Hawkins1; Alan L. Rockwood3; Edgar D. Lee2; H. Dennis Tolley1; Milton L. Lee1; 1Brigham Young 8:15 - 10:15 am University, Provo, UT; 2Torion, Provo, UT; 3ARUP MS STRATEGIES IN THE DETERMINATION OF Inst. for Clinical and Experimental Pathology, Salt PHOSPHORYLATION SITES Lake City, UT Chair: Pierre Thibault WOF pm 03:50 Pressure-Insensitive Bipolar Ion Detector (BID) ThOA am 08:15 Phosphopeptide Analysis by Mass Spectrometry: Based on Sequential Conversion Reaction; Yi- Trends, Technologies and Challenges; Ole N. sheng Wang; Ming-Hsin Li; Chung-Hsuan Chen; Jensen; Univ. of Southern Denmark, Odense, Yuan Tseh Lee; Academia Sinica, Taipei, TAIWAN Denmark WOF pm 04:10 Multiplexed Ion Mobility Spectrometry - ThOA am 08:35 Detection of Protein Phosphorylation Sites using 18 Orthogonal Time-of-Flight Mass Spectrometry; γ[ O4]-ATP and Mass Spectrometry; Timothy D. Mikhail Belov; Richard Smith; Pacific Northwest Veenstra1; Zhaojing Meng1; Andrew G. Jobson2; Yves National Laboratory, Richland, WA Pommier2; Ming Zhou1; 1SAIC-Frederick, Frederick, MD; 2National Cancer Institute, Bethesda, MD 2:30 - 4:30 PM ThOA am 08:55 Quantitative Proteomics for Protein Complex MS IN ELEMENTAL & METALLOMIC ANALYSES Study: Determination of True Protein Partners Chair: David W. Koppenaal and Characterization of their Phosphorylation 1 2 WOG pm 02:30 Isotope Dilution Laser Ablation ICP-MS for Direct Sites; Delphine Pflieger ; Martin Juenger ; Markus Mueller2; Oliver Rinner2; Hookeun Lee2; Peter and Accurate Determination of Trace Elements in 3 2 1 1 Gehrig ; Ruedi Aebersold ; LAMBE, CNRS, EVRY, Powdered Coal Samples; Klaus G. Heumann ; 2 2 1 1 France; Institute for Molecular Systems Biology, Sergei Boulyga ; Jens Heilmann ; University of 3 Mainz, Mainz, Germany; 2University of Natural ETH, Zürich, Switzerland; FGCZ, University of Resources, Vienna, Austria Zürich, Zürich, Switzerland WOG pm 02:50 Development of an Inductively Coupled ThOA am 09:15 Enrichment and Characterization of Histone H1 Plasma/Electrospray Ionization Dual-Source Time- Phosphorylation Isoforms in Chemoprevention of of-Flight Mass Spectrometer for Rapid Speciation Acute Myeloid Leukemia; Liwen Wang; Chen Ren; and Metallomic Analysis; Duane A. Rodgers; Steven Shujun Liu; Hua Xu; Guido Marcucci; Michael A J. Ray; Gary M. Hieftje; Indiana University, Freitas; Ohio State University, Columbus, OH Bloomington, IN ThOA am 09:35 A New Phosphoproteomic Strategy – Separation of WOG pm 03:10 Resonance Ionization Mass Spectrometry Analysis Mono- from Multi-Phosphorylated Peptides of Elemental Concentrations in Solar Wind Combined with Optimized MS3 mass Collectors of the Genesis Spacecraft; Igor Spectrometric Analysis; Tine E. Thingholm; Ole N. Veryovkin1; Emil Tripa1; Michael Savina1; Michael Jensen; Martin R. Larsen; University of Southern Pellin1; Donald Burnett2; 1Argonne National Denmark, Odense, Denmark Laboratory, Argonne, IL; 2California Institute of Technology, Pasadena, CA Page 20S 55th ASMS Conference on Mass Spectrometry ThOA am 09:55 The Cell Cycle Dependent Phosphoproteome and Zhibo Yang; Julia Laskin; Pacific Northwest National Proteome Analyzed by Quantitative Proteomics; Laboratory, Richland, WA Jesper V. Olsen; Michiel Vermeulen; Anna ThOC am 08:55 Mass Spectrometry, Electron Affinities and Non- Santamaria; Florian Gnad; Chanchal Kumar; Jürgen Covalent Interactions of DNA Bases and Base Cox; Erich A. Nigg; Matthias Mann; Max-Planck- Pairs; Edward C Chen; Edward S. Chen; University Institute for Biochemistry, Martinsried (near Munich), of Houston, Houston, TX Germany ThOC am 09:15 Noncovalent Binding Constants Determined by Mass Spectrometric Methods: Current Status, 8:15 - 10:15 am Limitations, and Future Prospects; Renato Zenobi; NEW ADVANCES IN CLINICAL MS Cédric Bovet; Matthias Jecklin; Sonal Mathur; David Chair: David S. Millington Touboul; Arno Wortmann; ETH Zurich, Zurich, ThOB am 08:15 Global NanoLC Microchip Profiling of Human Switzerland 1 ThOC am 09:35 Detection and Quantification of siRNA Double Serum Oligosaccharides; Caroline S. Chu ; Milady 1 1 R. Niñonuevo1; Patrick D. Perkins2; Hongfeng Yin2; Strands by MALDI-MS; Michael Karas ; Ute Bahr ; 2 2 1 Hüseyin Aygün2; 1JW Goethe Univ. of Frankfurt, Kevin Killeen ; Rudolf Grimm ; Carlito B. Lebrilla ; 2 1University California, Davis, Davis, CA; 2Agilent Frankfurt am Main, Germany; BioSpring, Frankfurt, Technologies, Santa Clara, CA Germany ThOB am 08:35 Large-scale Identification of Exfoliated Cellular ThOC am 09:55 Equivalency of Binding Sites in Protein-Ligand Proteins in Whole Saliva from Oral Cancer Complexes Revealed by Time-Resolved Tandem Mass Spectrometry; Glen K. Shoemaker1; Elena N. Patients via Value-Added Three-Dimensional 1 2 1 Peptide Separation and MS/MS; Hongwei Xie1; Kitova ; Monica M. Palcic ; John S. Klassen ; 1 1 1 1University of Alberta, Edmonton, Canada; Getiria Onsongo ; Jonathan Popko ; John V. Carlis ; 2 Robert J. Griffin2; Nelson L. Rhodus1; Timothy J. Carlsberg Laboratory, Copenhagen, Denmark Griffin1; 1University of Minnesota, Twin Cities, Minneapolis, MN; 2University of Arkansas for 8:15 - 10:15 am Medical Sciences, Little Rock City, AK ANALYSIS OF REACTIVE METABOLITES BY MS Chair: Ian A. Blair ThOB am 08:55 Quantitative Analysis of Five HIV-1 Protease ThOD am 08:15 Reactive Metabolites and Mass Spectrometry: Inhibitors in Cell Lysates by MALDI-FTICR Mass Detection and Identification over the Past 10 Spectrometry; Jeroen J.A. van Kampen2; Peter C. Years; Elizabeth M. Joshi; Eli Lilly and Company, Burgers2; Ronald de Groot1; Albert D.M.E. Indianapolis, IN Osterhaus2; Esther J. Verschuren2; Rob A. Gruters2; ThOD am 08:35 Studying the Mechanism of Protein Covalent Theo M. Luider2; 1UMC st. Radboud, Nijmegen, the Binding of Fipexide via Reactive Metabolites by Netherlands; 2Erasmus Medical Center, Rotterdam, Mass Spectrometry; Lekha Sleno; Gérard the Netherlands Hopfgartner; University of Geneva, Geneva, ThOB am 09:15 Biosynthesis of [U-15N]labeled Deoxycytosine and Switzerland Methyldeoxycytosine for Use as Internal Standards ThOD am 08:55 Rapid and Sensitive Screening of GSH-Trapped for Determining Percentage DNA Methylation by Reactive Metabolites using MRM-Dependent LC-MS/MS; Eoin P Quinlivan; Jesse F Gregory; MS/MS Scan on a Triple Quadruple-Linear Ion University of Florida, Gainesville, FL Trap Mass Spectrometer; Joanna Zheng; Li Ma; ThOB am 09:35 Detection, Characterization, and Monitoring of Baomin Xin; Timothy Olah; W. Griffith Humphreys; Emerging Influenza Virus Genotypes by Mass Mingshe Zhu; PCO, Bristol-Myers Squibb, Princeton, Spectrometry; Steven Hofstadler; Ranga Sampath; NJ Vanessa Harpin; Christian Massire; Larry Blyn; Mark ThOD am 09:15 LC/MS Analysis of Reactive Metabolites from Eshoo; Thomas Hall; Amy Schink; Jared Drader; Cyclooxygenase-2-Mediated Arachidonic Acid James Hannis; Maria Tobarmosquera; David Ecker; Metabolism; Seon HWA Lee1; Michelle V. IBIS Biociences, Carlsbad, CA Williams2; Angela Wehr1; Kannan Rangiah1; Ian A. ThOB am 09:55 Measuring Endogenous Estrogens and Estrogen Blair1; 1Univ. of Pennsylvania, Cntr. Cancer Phar, Metabolites in Human Peritoneal Fluid by Liquid Philadelphia, PA; 2Massachusetts Institute of Chromatography-Tandem Mass Spectrometry; Xia Technology, Cambridge, MA Xu1; Essam el-dine R. Othman2; Daniela Hornung3; ThOD am 09:35 Characterization of Protein Adducts of Sulfuryl Ayman Al-Hendy2; Timothy D. Veenstra1; 1SAIC- Fluoride with Albumin Protein in the Male F344 Frederick, Frederick, MD; 2University of Texas Rat via PESI-LC/MS/MS; Fagen Zhang1; Michael Medical Branch, Galveston, TX; 3University of Bartels1; David L. Rick1; Dave L. Eisenbrandt2; 1Dow Schleswig-Holstein, Lüebeck, Germany Chemical, Midland, MI; 2Dow AgroSciences, Indianapolis, IN 8:15 - 10:15 am ThOD am 09:55 Iron-Catalyzed Oxidation of ApoB-100 in Low NON-COVALENT INTERACTIONS Density Lipoproteins in vitro Is Selective for Chair: Mary T. Rodgers Production of Kynurenines from WE Sequences; Charles V. Smith1; Hsin-hung Chen2; Ching-Yi ThOC am 08:15 Noncovalent Interactions between Alkali Cations 3 4 3 and Amino Acids: Effects of the Side Chain; Peter Chen ; Lu-Ping Chow ; Hsu-Ching Hsu ; Yuan-Teh Lee3; Chao-yuh Yang2; 1Seattle Children's Hospital B. Armentrout; Amy Heaton; Sha Ye; Robert M. 2 Moision; Amy Clark; University of Utah, Salt Lake Research Institute, Seattle, WA; Baylor College of Medicine, Houston, TX; 3National Taiwan University City, UT 4 ThOC am 08:35 Experimental and Theoretical Studies of the Hospital, Taipei, Taiwan; National Taiwan Structures and Interactions of Vancomycin University, Taipei, Taiwan Antibiotics with Cell Wall Analogues Peptides; 55th ASMS Conference on Mass Spectrometry Page 21S

8:15 - 10:15 am 8:15 - 10:15 am ION MOBILITY SPECTROMETRY: NEW DEVELOPMENTS CHARACTERIZING EMERGING IN BIOANALYTICAL APPLICATIONS ENVIRONMENTAL CONTAMINANTS WTH MS Chair: John A. McLean Chair: Mehran Alaee ThOE am 08:15 Ion Mobility: The Method and Recent ThOG am 08:15 Comparison of LC/QQQ and LC/TOF-MS for the Applications; Michael T. Bowers; University of Analysis of 100 Pesticides in Food and Water: California, Santa Barbara, CA Finding the “Crossover Point”; Earl Michael ThOE am 08:55 The Perils of the Plasma Proteome Map Thurman1; Imma Ferrer2; Yanyan Fang3; Paul Determined by Multidimensional Liquid Zavitsanos4; Jerry A. Zweigenbaum4; 1Costacabana Chromatography-Ion Mobility-Mass Mass Spectrometry Group, Almeria, Spain; Spectrometry; Stephen Valentine1; Xiaoyun Liu2; 2University of Almeria, Almeria, Spain; 3Agilent Manolo D. Plasencia2; Sarah Trimpin2; Stephen Technologies, Inc., Beijing, China; 4Agilent Naylor1; David E. Clemmer2; 1Predictive Physiology Technologies, Inc, Wilmington, DE and Medicine, Inc., Bloomington, IN; 2Indiana ThOG am 08:35 Determination of b-Blockers in Environmental University, Bloomington, IN Waters by Molecularly Imprinted Polymers ThOE am 09:15 Enhancing Imaging Mass Spectrometry with Ion followed by Advanced Liquid Chromatography- Mobility; Whitney B. Ridenour; Richard M. Caprioli; Tandem Mass Spectrometry (Qq-LIT); Damià John A. McLean; Vanderbilt University, Nashville, Barceló; IIQAB-CSIC, Environmental Chemistry TN Department, Barcelona, Spain ThOE am 09:35 Applications of Ion Mobility/Mass Spectrometry in ThOG am 08:55 Trace Analysis of Antidepressant Pharmaceuticals Pharmaceutical and Bioanalysis; Colin S. Creaser1; and Selected Degradates in Environmental Emma L. Harry1; Mark D. Howdle1; Natali Budimir1; Matrices by LC/ESI/MS/MS; Melissa M. Schultz1; Daniel J. Weston1; Christine Eckers2; Alice Laures2; Edward T. Furlong23; Dana W. Kolpin23; 1The College Anthony W.T. Bristow34; Ian D. Wilson34; of Wooster, Wooster, OH; 2U.S. Geological Survey, 1Nottingham Trent University, Nottingham, United Denver, CO; 3U.S. Geological Survey, Iowa City, IA Kingdom; 2GlaxoSmithKline, Stevenage , United ThOG am 09:15 Solvent Effects in Electrospray Ionization of Kingdom; 3AstraZeneca, Macclesfield, United Naphthenic Acids from Athabasca Oil Sands; John Kingdom; 4AstraZeneca, Alderley Edge, United V Headley1; Kerry M. Peru1; Mark P. Barrow 2; Kingdom Peter J. Derrick2; 1Environment Canada, Saskatoon, ThOE am 09:55 Ion Mobility-Mass Spectrometry of Large Protein Canada; 2Inst Mass Spect. Dept.of Chemistry Complexes: from Activated Ions to Polydisperse University of W, Coventry, United Kingdom Assemblies; Brandon T. Ruotolo; Suk-Joon Hyung; ThOG am 09:35 ToF-SIMS Spectral Analysis of Nanotube and Justin L.P. Benesch; Carol V. Robinson; University of Fullerene Materials; Albert Fahey; Christopher Cambridge, Department of Chemistry, Cambridge, Szakal; National Institute of Standards and United Kingdom Technology, Gaithersburg, MD ThOG am 09:55 Intact Estrogen Receptor Complexes Measured by 8:15 - 10:15 am Chip-Based Nanoelectrospray and MALDI Mass FTMS INSTRUMENTATION Spectrometry: An Approach to Identify and 1 Chair: Ryan M. Danell Classify Endocrine Disruptors; Cédric Bovet ; Arno 1 2 2 ThOF am 08:15 Recent Advances in FT-ICR Mass Spectrometry Wortmann ; Marc Ruff ; Sylvia Eiler ; Florence 2 3 3 Instrumentation; David C. Muddiman; North Granger ; Alexis Nazabal ; Ryan Wenzel ; Bertran 4 2 1 1 Carolina State University, Raleigh, NC Gerrits ; Dino Moras ; Renato Zenobi ; ETH Zurich, 2 ThOF am 08:55 Iterative Accumulation Multiplexing of ESI- Zürich, Switzerland; Institut de Génétique et de 3 Generated Ions on a Fourier Transform Ion Biologie Moléculaire, Illkirch, France; CovalX AG, 4 Cyclotron Resonance Mass Spectrometer; Jared Zürich, Switzerland; Functional Genomics Center Bushey1; Gary Glish1; Ryan Danell2; 1University of Zurich, Zürich, Switzerland North Carolina at Chapel Hill, Chapel Hill, NC; 2Danell Consulting, Greenville, NC 10:15 am – 2:30 pm ThOF am 09:15 What to Do with Peptide CID Fragments? POSTER SESSION AND EXHIBITS Alexander Scherl1; Scott A. Shaffer1; Gregory K. Taylor1; Patricia Hernandez2; Ron D. Appel2; Pierre- THURSDAY AFTERNOON Alain Binz3; David R. Goodlett1; 1University of Washington, Dpt. Medicinal Chemistry, Seattle, WA; 2:30 - 4:30 PM 2 Swiss Institute of Bioinformatic, Geneva, MS IN THE DETERMINATION OF CELLULAR PATHWAYS 3 Switzerland; GeneBio SA, Geneva, Switzerland Chair: Ileana M. Cristea ThOF am 09:35 Pushing Intact Protein Detection Limits of the ThOA pm 02:30 Quantitative Approaches to the Study of Cellular Orbitrap Mass Analyzer; Eduard Denisov; Kerstin Pathways; Simon J. Gaskell1; Robert J Beynon2; Strupat; Alexander Makarov; Vlad Zabrouskov; 1University of Manchester, Manchester, United ThermoFisher Scientific (Bremen) GmbH, Bremen, Kingdom; 2University of Liverpool, Liverpool, United Germany Kingdom ThOF am 09:55 Automating a 12 Tesla FTMS for High- ThOA pm 02:50 System-Biology Analysis of Interferon-γ Activated Throughput Tandem Mass Spectrometry above 10 Mouse Macrophages: from the Cytosol to the kDa; Dana E. Robinson; Craig D. Wenger; Bryan A. Phagosome; Matthias Trost1; Maria Marcantonio1; Parks; Michael T. Boyne II; Lihua Jiang; Richard D. Mathieu Courcelles1; Michel Desjardins2; Pierre LeDuc; Paul M. Thomas; Neil L. Kelleher; University Thibault1; 1Institute for Research in Immunology and of Illinois, Urbana, IL Cancer, Montréal, Canada; 2Dept. Patho. & Cell Biol., Université de Montréal, Montréal, Canada Page 22S 55th ASMS Conference on Mass Spectrometry

ThOA pm 03:10 Combining Mass Spectrometry and 2:30 - 4:30 PM Computational Modeling to Dissect Metabolic CLINICAL ASSAYS WITH MASS SPECTROMETRY 1 2 Network Dynamics; Jie Yuan ; William U Fowler ; Chair: Alfred L. Yergey Chris Doucette2; Ned Wingreen2; Joshua D 1 2 1 ThOC pm 02:30 Mass Spectrometry in Routine Clinical Chemistry: Rabinowitz ; Herschel A Rabitz ; Lewis-Sigler Past, Present and Future; Mark W Duncan; Institute, Princeton University, Princeton, NJ; 2 UCDHSC, Aurora, CO Princeton University, Princeton, NJ ThOC pm 02:50 MALDI-TOF Mass-Spectrometry Based ThOA pm 03:30 Proteomic and Genomic Analysis of Nuclear Minisequencing Method for Rapid Detection Receptor Signaling Pathways; Patrick R Griffin; Mycobacterim Tuberculosis Resistance to Jennifer Caldwell Busby; Scott A Busby; Valerie Rifampicin, Isoniazid and Ethambutol; Vadim M. Cavett; Michael J Chalmers; Bruce D Pascal; Swati Govorun; Elena N. Il’ina; Maxim V. Afanas’ev; Prasad; Layton H Smith; Mark R Southern; The Larisa N. Ikryannikova; Research Institute for Scripps Research Institute, Jupiter, FL Physical-Chemical Medicine, Moscow, Russian ThOA pm 03:50 Mass Spectrometric Signatures of the Proteolytic Federation Activity of Aspergillus fumigatus during Invasive ThOC pm 03:10 Drugs of Abuse Screening and Confirmation of Pulmonary Aspergillosis; Karine Bagramyan; Teresa Positives for Amphetamines by LC/MS/MS: B. Hong; Joseph M. Lyons; James I. Ito; Markus LC/MS/MS Compares Favourably to both Kalkum; City of Hope, Duarte, CA Immunoassays and GC/MS; Jeff C. Eichhorst1; ThOA pm 04:10 Analysis of Protein Kinase - Substrate Networks Denis C. Lehotay2; Michele L. Etter1; Patrick by Quantitative Phosphoproteomics; Bernd Rogoschewsky1; 1Saskatchewan Disease Control Bodenmiller1; Lukas N. Mueller1; Claudine Kraft1; 2 2 1 Laboratory, Regina, Canada; University of Mi-Youn Brusniak ; Matthias Gstaiger ; Ruedi Saskatchewan, Dept. of Pathology, Saskatoon, Aebersold1; 1ETH Zürich, Zurich, Switzerland; 2 Canada Institute for Systems Biology, Seattle, WA ThOC pm 03:30 Evaluation of a Multi-Parameter Biomarker Set for Oxidative Damage: DNA/RNA, Lipid, and 2:30 - 4:30 PM Protein Oxidation Products in Human Samples; BIOINFORMATIC ADVANCES FOR MS Yali Su; Czarina Cortez; Rui Tan; Chris Heward; Chair: David Fenyo Kronos Science laboratory, Phoenix, AZ ThOB pm 02:30 Optimizing Sensitivity and Specificity in Data ThOC pm 03:50 Evaluation of an iTRAQ™ Reagent Amino Acid Analysis of Protein and Peptide Mass Spectra; Jan Analysis Kit for the Rapid Quantitation of Amino Eriksson; Swedish University of Agricultural Acids in Plasma; Jean Lacey1; Bruno Casetta2; Scott Sciences, Uppsala, Sweden Daniels3; Subodh Nimkar4; Dietrich Matern1; 1Mayo ThOB pm 02:50 The Partition Function of Tandem Mass Spectra: Clinic College of Medicine, Rochester, MN; 2Applied A New Approach to Evaluating Statistical Biosystems, Monza, Italy; 3Applied Biosystems, Significance of Peptide Identifications; Pavel Framingham, MA; 4Applied Biosystems, Foster City, Pevzner; Sangtae Kim; Nitin Gupta; UCSD, La Jolla, CA CA ThOC pm 04:10 The Analysis of Thyroxin (T4) in Filter Paper ThOB pm 03:10 Unsupervised Pattern Recognition and the Blood Specimens using Flow Injection Generation of Decoy Databases for Modeling Electrospray MS/MS; Donald H. Chace1; James Tandem Mass Spectrum/Peptide Sequence False DiPerna2; Scott Singelton2; Mauro Aiello3; 1Pediatrix Match Frequencies; Jian Feng1; Daniel Naiman1; Analytical, Bridgeville, PA; 2Pediatrix Screening, Bret Cooper2; 1The Johns Hopkins University, Bridgeville, PA; 3MDS Sciex, Concord, ON, Canada Baltimore, MD; 2USDA-ARS, Beltsville, MD ThOB pm 03:30 MS/MS Libraries of Identified Peptides and 2:30 - 4:30 PM Recurring Spectra in Protein Digests; Stephen E, PROFILING DRUG METABOLITES BY MS Stein; Lisa Kilpatrick; Jeri Roth; Paul Rudnick; Chair: Richard van Breemen Xiaoyu (Sara) Yang; NIST, Gaithersburg, MD ThOD pm 02:30 Metabolic Profiling of Biologically Active ThOB pm 03:50 Study of Fragmentation Patterns of Modified Flavanones; Dejan Nikolic1; Frederick Roelens2; Peptides and their Native Counterparts; Mikhail 2 1 1 1 1 Denis De Keukeleire ; Richard B. van Breemen ; Savitski ; Michael L Nielsen ; Roman A Zubarev ; 1University of Illinois College of Pharmacy, Chicago, 1biological and Medical Mass Spectrometry, Uppsala, 2 2 IL; Ghent University, Ghent, Belgium Sweden; Biological and Medical Mass Spectrometry, ThOD pm 02:50 Positive/Negative Polarity Switching Mass Uppsala, Sweden Spectrometry in Metabolite Identification; Bill ThOB pm 04:10 Bioinformatics Algorithms and Software Enabling Fitch; Yaping Tu; Ludmila Alexandrova; Limin He; Whole Proteome Quantitation Applied to Diploid Roche, Palo Alto, CA vs. Haploid Yeast Cells; Juergen Cox; Lyris de ThOD pm 03:10 Metabolite Structure Elucidation by Differential Godoy; Gustavo de Souza; Jesper V. Olsen; Shubin Fragmentation between Positive and Negative Ren; Matthias Mann; Max-Planck-Institute of Ionization Modes using LTQ Ion Trap Mass Biochemistry, Martinsried, Germany Spectrometry; Steven X Hu; Michael Martin; TargeGen, Inc., San Diego, CA ThOD pm 03:30 Using LC/MS Based Metabonomics to Understand the Role of Gut Microflora in Mammalian Metabolism using Axenic Rats; Robert Plumb1; Jeremy Nicholson1; Ian Wilson2; Paul Rainville3; 1Imperial College, London, United Kingdom; 2Astra Zeneca, Macclesfield, UK; 3Waters Corporatiion, Milford, MA 55th ASMS Conference on Mass Spectrometry Page 23S ThOD pm 03:50 A Unique Approach to Metabolism Profiling of ThOF pm 03:50 Progress in Coupling a Differential Mobility Large Peptides in Biological Matrices using On- Analyzer to the Source End of a Mass Line LC/MS and Principal Component Analysis Spectrometer for IMS-MS Studies; Juan Fernandez Software; Miryam Kadkhodayan*; Yan Wang; de la Mora2; Juan Rus1; Francisco Estevez1; Juan Isabelle Tcholakov; Chris Bellows; Amylin Antonio Sillero1; 1SEADM, Boecillo, Spain; 2Yale Pharmaceuticals, Inc., San Diego, CA University, New Haven, CT ThOD pm 04:10 Metabolite Identification Studies using UPLC™- ThOF pm 04:10 Enhanced Protein Detection in Proteomics Radiodetection-QToF-MS; Mark D. Wrona1; Experiments using High-Field Asymmetric Ion Christine Dieckhaus-Fandozzi2; Carl Berthelette1; Mobility Spectrometry on an Orbitrap Mass Kevin P. Bateman1; 1Merck Frosst Canada & co, Spectrometer; Julian Saba; Eric Bonneil; Pierre Kirkland, Quebec, Canada; 2Merck Research Thibault; University of Montreal, Montreal, Quebec, Laboratories, West Point, PA Canada

2:30 - 4:30 PM 2:30 - 4:30 PM MS OF OXIDIZED PROTEINS ION STRUCTURES DETERMINED BY MS Chair: Richard W. Vachet Chair: John R. Eyler ThOE pm 02:30 Three-Dimensional Structure of Cofilin Bound to ThOG pm 02:30 Auxiliary Gas Phase Methods for Structure Monomeric Actin Derived by Structural Mass Elucidation by Mass Spectrometry; Herbert H Hill1; Spectrometry Data; J.K. Amisha Kamal1; Sabrina Brad Bendiak2; Harry Zhu1; Mathew Pollard1; Prabha Benchaar2; Keiji Takamoto1; Emil Reisler2; Mark Dwivedi1; Maggie Tam1; 1Washington State Chance1; 1Case Western Reserve University, Universtiy, Pullman, WA; 2University of Colorado, Cleveland, OH; 2University of California Los Denver, CO Angeles, Los Angeles, CA ThOG pm 02:50 Structural Determination of Nucleobases and ThOE pm 03:10 Characterization of Electrochemical-Induced Nucleosides using Surface-Enhanced Raman Protein Oxidation as a Probe for Higher Order Scattering of Soft and Reactively Landed Ions on Protein Structural Interrogation; Robert Hettich; Silver Surfaces; Karl E. Jackson; Michael Volný; Carlee McClintock; Vilmos Kertesz; Oak Ridge Matt Diener; František Turecek; University of National Laboratory, Oak Ridge, TN Washington Department of Chemistry, Seattle , WA ThOE pm 03:30 Probing Oxidative Stress using Intact Protein LC- ThOG pm 03:10 Hydrogen/Deuterium Exchange of Alanine MS; Ljiljana Pasa-Tolic; Natacha M. Lourette; Oligomeric Peptides: A Case Study of HAAAA; Heather S. Smallwood; Si Wu; Curt B. Boschek; Brittany R. Perkins; Kristin A. Herrmann Favela; Thomas C. Squier; Richard D. Smith; Pacific NW Linda Breci; Vicki Wysocki; Chemistry Department, Nat'l Lab, Richland, WA University of Arizona, Tucson, AZ ThOE pm 03:50 In vivo Protein Targets of Reactive Lipid ThOG pm 03:30 Shedding Light on the Structures of CID and HDX Peroxidaton Products; Juan Chavez; Bingnan Han; Product Ions; Nick C Polfer1; Bela Paizs2; John R Jan F. Stevens; Claudia S. Maier; Oregon State Eyler3; Rob C Dunbar4; Jos Oomens5; 1Fritz-Haber- University, Corvallis, OR Institut, Berlin, Germany; 2German Cancer Research ThOE pm 04:10 Towards the Proteomic Mapping of Endogenous Center, Heidelberg, Germany; 3University of Florida, Sites of HNE Modification: A Two-Step Solid- Gainesville, FL; 4Case Western University, Phase Enrichment Strategy for HNE-Modified Cleveland, OH; 5FOM Institute 'Rijnhuizen', Peptides; Mikel R Roe; Hongwei Xie; Juan Feng; Nieuwegein, Netherlands Danni L Meany; LaDora V Thompson; Edgar A ThOG pm 03:50 Mid-Infrared Spectroscopy of Cationized Arginine Arriaga; Timothy J Griffin; University of Minnesota, Complexes: The Transition from Nonzwitterionic Minneapolis, MN to Zwitterionic Arginine; Rebecca A. Jockusch1; Matthew W. Forbes1; Matthew F. Bush2; Evan R. 2 3 3 1 2:30 - 4:30 PM Williams ; Nick C. Polfer ; Jos Oomens ; University 2 ION MOBILITY INSTRUMENTATION of Toronto, Toronto, Canada; University of 3 Chair: Alexandre A. Shvartsburg California, Berkeley, Berkeley, CA; FOM Institute ThOF pm 02:30 Recent Advances in FAIMS/IMS/MS for Plasma Physics "Rijnhuizen", Nieuwegein, the Instrumentation; Keqi Tang; Richard D. Smith; Netherlands Pacific NW National Laboratory, Richland, WA ThOG pm 04:10 Cation-Pi Interactions and Complexes of Alkali Metal Ions with Aromatic Dipeptides. An IRMPD ThOF pm 02:50 Multidimensional IMS-MS for the Analysis of 1 Complex Mixtures; David E. Clemmer; Samuel Structure Investigation; Robert C. Dunbar ; Nick C. Polfer2; Jos Oomens2; 1Case Western Reserve Univ., Merenbloom; Ruwan Kurulugama; Brian Bohrer; 2 Indiana University, Bloomington, IN Cleveland, OH; FOM Institute for Plasma Physics, ThOF pm 03:10 New Concepts for Ion Mobility-Mass Spectrometry Nieuwegein, Netherlands (IM-MS) Instruments; David H. Russell; Texas A&M University, College Station, TX 4:45 - 5:30 pm ThOF pm 03:30 Ion Separations in Differential Mobility PLENARY LECTURE Spectrometry through Control of Pressure, Samuel Gandy Temperature and Chemical Modifiers in the Farber Institute for Neurosciences Supporting Atmosphere; Gary A. Eiceman1; Erkinjon G Nazarov2; Stephen L. Coy2; Evgeny V. Krylov2; Raanan A. Miller2; 1New Mexico State University, Las Cruces, NM; 2Sionex Corporation, Inc, Bedford, MA