DOCSLIB.ORG

ANALYTICAL CHEMISTRY417 Doi:10.2533/Chimia.2007.417 CHIMIA 2007, 61,No

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
ANALYTICAL CHEMISTRY417 Doi:10.2533/Chimia.2007.417 CHIMIA 2007, 61,No WERNER PRIZE 2007/GRAMMATICAKIS-NEUMANN PRIZE 2007/ANALYTICAL CHEMISTRY417 doi:10.2533/chimia.2007.417 CHIMIA 2007, 61,No. 7/8 Werner Prize 1 Gramaticakis –Neumann Prize 2007 2 From Simplicity to Complexity via Subcomponent Self-Assembly Photoinduced functions in multicomponent molecular systems Jonathan Nitschke,Marie Hutin, David Schultz,RupamJ.Sarma, SerenaSilvi,Alberto Credi* Victoria E. Campbell, Gérald Bernardinelli Dipartimento di Chimica G. Ciamician, Università degli Studi di Bologna, Organic ChemistryDepartment, University of Geneva, 30 quai Ernest- via Selmi 2, I-40126 Bologna,Italy Ansermet, 1211 Genève 4 Light-induced processesare at the basis of fundamental natural phenomena Thecreation of complexstructures from simple building blocks via ther- as wellasofavariety of applications.Since thefunctions that can arise modynamic self-assembly requires an understanding of the rules followed from the interaction between light andmatterdependonthe degreeofcom- duringthe self-organizationprocess. Since theinceptionofthisresearch plexity and organizationofthe receiving matter, theresearch on these program in August2003, we have sought to identify theserules and to apply processeshas progressively moved frommoleculartosupramolecular(mul- themtosynthetic problems.Subcomponent self-assembly1 describessys- ticomponent) systems.Examples of multicomponent systems capable to tems in which simple amines and aldehydesmay be induced to come to- perform specific functions under light stimulation (photochemical molecular gether around metal-ion templates via the formation of imine (C=N) devices, PMDs)have been developed [1], relying on processessuch as pho- bonds. 2,3 We have thus been abletocreatecomplex structures such as a toisomerization and photoinduced electron or proton transfer. 4 catenane (below, right) or apair of helical molecules linked at aright angle Herewewill describeafew recent examples of PMDs studied in our labora- through metal coordination (below,left),having atertiarystructuresimilar tories[2],designed to (i)processbinaryinformation (molecular logic gates to that of aprotein. Thesestructures arecapable of dynamic reassembly at 5 andcircuits)or(ii) undergo controllablemotions of some molecular com- both NMetal and C=Nlinkages. ponentswith respect to the others(molecular machines). Apart from futuristic applications,investigations on PMDs can increasethe H H N basic understanding of avariety of processes, as well as develop reliable N theoretical models.Thisresearch hasalsothe important merit of stimulating O O theingenuity of chemists,thereby instilling newlifeinto chemical sciences. N N N Cu+ N N Cu+ N N N O O [1] V. Balzani, A. Credi, M. Venturi, Molecular Devices and Machines , Wiley-VCH, Weinheim, 2003.A.Credi, Aust.J.Chem. 2006, 59,157. N H H N [2]V.Balzani,M.Clemente-León, A. Credi,B.Ferrer, M. Venturi, A.H. 1. J.R. Nitschke Acc. Chem.Res. 2007,40, 103 Flood, J.F. Stoddart, Proc. Natl.Acad. Sci.USA 2006, 103,1178.R. 2. J.R. Nitschke,M.Hutin,G.Bernardinelli Angew. Chem.Int.Ed. 2004,43, 6724 Ballardini, A. Credi, M.T. Gandolfi, F. Marchioni, S. Silvi, M. Venturi, 3. M. Hutin, G. Bernardenelli,J.R.Nitschke Proc.Natl. Acad. Sci. USA 2006,103, 17655 Photochem. Photobiol.Sci. 2007, 6 ,345.S.Silvi,E.C.Constable, F.M. 4. M. Hutin, C.A. Schalley,G.Bernardinelli,J.R.Nitschke Chem.Eur.J. 2006,12, 4069 Raymo, A. Credi, submitted. 5. D. Schultz,J.R.Nitschke Proc.Natl.Acad. Sci. USA 2005,102, 11191 Analytical Chemistry 3 Analytical Chemistry 4 Snapshots of aheterogeneous catalystatwork: From integral Chemometrictoolstosimplifymethoddevelopment:screeningofdop- towardsspatially resolved spectroscopicmonitoringofsolid materials ing agentsinurinary samples. Jan-DierkGrunwaldt1 ,Stefan Hannemann1 ,BertramKimmerle1 , Ivano Marchi,Serge Rudaz, Jean-LucVeuthey Alfons Baiker1 ,Pit Boye2 ,JensPatommel 2 ,Christian G. Schroer2 LaboratoryofAnalytical Pharmaceutical Chemistry, School of Pharmaceu- 1 Institute forChemical andBioengineering, Department of Chemistry and tical sciences,University of Geneva, University of Lausanne, Bd d'Yvoy 20, Applied Biosciences,ETH Zurich, Hönggerberg, HCI, CH-8093 Zürich 1211 Geneva 4, Switzerland 2 Institute of Structural Physics,TUDresden, D-01062 Dresden Analysesinanti-doping control occur in two steps. First,ageneric To gain information on the structureofsolidmaterials such as heterogene- fast screening analysis is used to determinethe presence of alarge number ouscatalysts,insitu X-rayabsorption spectroscopy (XAS)isawell-suited of forbidden compounds in urine. Second,inthe caseofpositive result, a technique. In certain processesthe structureofacatalystmay varyalong a specific procedure(confirmatoryanalysis)has to be performed to quantify catalytic reactor particularly if prominent gradients in temperatureorcon- thesubstance(s). centration occur.The investigation of these phenomena requires spatially Screening method development is tedious and time consuming due resolved techniques on amicroscale. to the necessity to optimizethe sample preparation of alarge quantity of Here we present structural data of noblemetal catalysts during partial oxida- compounds.The useofchemometric toolsisthereforeproposed to reduce tionofmethane (CPO). To efficiently recordXAS spectra in alocally re- the number of tested analytes in method development by choosing represen- solved way, anew approach is suggestedusing aCCD-camera[1].The re- tative compounds of the whole set. sults arecomparedtothosefromXAS-measurements. In addition,the In this study, agroup of thirty-sixdoping agents consisting of diuretics temperaturegradientwas determined usinganinfraredcamera[2].Acor- and beta-blockerswas used. Astandardsolution containing all analytes was relation between the structure of the catalyst, the catalytic data andthe axial loaded, washed and eluted with four different SPEsorbents.All fractions temperatureprofile in the catalytic reactor was established. Tremendous were collected and each compound wasretrieved by LC-ESI-MS. In order structural changes of the noble metal particles within agradient of lessthan to bringout differences among compounds,amultivariate analysis approach 100 mm thicknessand astrong dependence of thegradient on the reaction was used. Asmall number of groups emerged and subsequent method de- conditions (temperature, space velocity)wereobserved. Veryrecently, velopment was performed by selecting representative compounds in the "snapshots" werenot only taken of the variation in catalyststructureand obtained clusterisation. temperature, but we even succeeded in following thesechanges in a time-resolvedmannerusing aCCD-and an IR-camera. [1]J.-D. Grunwaldt, S. Hannemann, C.G. Schroer, A. Baiker, J. Phys. Chem. Lett. B 2006, 110, 8674; J.-D.Grunwaldt, S. Hannemann, A. Baiker, P. Boye,C.G. Schroer,Highlights of Analytical Chemistry, Chimia 2006, 60, 709. [2]S.Hannemann, B. Kimmerle, J.-D.Grunwaldt, A. Baiker, P. Boye,C.G. Schroer,inpreparation. ANALYTICAL CHEMISTRY418 CHIMIA 2007, 61,No. 7/8 Analytical Chemistry 5 Analytical Chemistry 6 Microchip electrophoresis bioanalytical applications Development of amethodtocharacterize nanoparticle uptakeinto Corn plants Marketa Vlckova, MariaA.Schwarz Karin Birbaum 1 ,RobertBrogioli1 ,Ludwig Limbach2 ,EnricoMartinoia3 , University of Basel, Spitalstrasse 51, 4056 Basel, Switzerland Wendelin Stark 2 ,Detlef Günther1 Theimplementation of microfabricated separation devices (socalledmicro- 1 LaboratoryofInorganic Chemistry, ETH Zurich,Wolfgang-Pauli Strasse chips)inelectrophoresis has become atrend in modernseparation science. 10, 8093 Zurich,Switzerland However,the miniaturization of the separation to microchip brings along 2 Institute for Chemical andBioengineering,ETH Zurich, Wolfgang-Pauli some benefits (speed,negligible consumption of substances or high Strasse 10, 8093 Zurich,Switzerland throughput analysis)alsosome drawbacks(limited separation efficiency and 3 Laboratoryfor Molecular Plant Physiology, University of Zurich,Zolliker- selectivity, higherdetection limits or the absenceofautomation). strasse 107, 8008 Zurich, Switzerland Nevertheless, in some applicationareas theadvantages of themicrochip separations overcome the limitations.Adevelopmentofaselective andsen- Nanoparticles (NP) areincreasingly used in various applications e.g. as sitive detection, often involving expensive reagents,orafast development catalysts or millingagents.Thereforerisks of exposureduring production of aseparation method could be listed as the examples of such applications. processesand distribution in the environment requireclarification about the Specificmeasurementsfor particular purposes (affinity measurementsand potentialrisks.Studies using human lung cellshaveshown that agglomera- other)represent then further useful applications of microchips tion, sedimentation and diffusion of NP affect uptake by cells [1]. This Thelisted applications areas of microchips willbedemonstrated by present- study has investigated the uptake of CeO 2 NP during exposuretoairborne ing the results of our research.The sensitivity of amperometric detection of NP into Corn plants. catecholamines has been specifically enhanced with thehelpofenzymes [1] Forthe experiments,the plants wereplaced in aglove box that allowed the andalsocarbon nanotubes [2]. Acomplex separation method has been de- production of NP flame spraysynthesis in situ forashortduration (~1min). veloped forsimultaneous separation of allthree catecholamines and their TheNPare distributed within the glove box by afan.The plants remain
Load more

Recommended publications
  • 2017 WEEKLY BULLETIN DEPARTMENT of CHEMISTRY, NORTHWESTERN UNIVERSITY EVANSTON, ILLINOIS April 24, 2017
    2017 WEEKLY BULLETIN DEPARTMENT OF CHEMISTRY, NORTHWESTERN UNIVERSITY EVANSTON, ILLINOIS April 24, 2017 For full schedule, including Center events, please see the Department Calendar: http://www.chemistry.northwestern.edu/events/calendar.html Tuesday April 25th: Faculty Lunch Seminar: Neil Kelleher Tech K140 12:00 – 1:00pm Friday April 28th: Chemistry Department Colloquium: Stacey F. Bent, Stanford University Tech LR3 4:00-5:00pm BIP BIP meets every Friday 10-11:00am in Tech K140 Arrivals We did not have any new arrivals Announcements 10th Annual ANSER Solar Energy Symposium April 27-28, 2017: The Argonne-Northwestern Solar Energy Research Center (ANSER) and the Institute for Sustainability and Energy at Northwestern (ISEN) are delighted to host the 10th annual ANSER Solar Energy Symposium – “Solar Electricity.” As our understanding of the impact of climate change continues to grow, so too does the global trend towards a clean-energy economy. The last two years have seen organic photovoltaics reach efficiencies of 11.5 percent, quantum dot solar cells reach efficiencies of 11.3 percent and perovskite solar cells continue their meteoric rise to efficiencies of 22.1 percent, paving the way for continually decreasing photovoltaic costs. This encouraging march toward a cleaner power sector cannot be ignored, and is built on the foundation of innovative research being carried out at collaborative scientific hubs such as the ANSER Center. The thematic focus of this year’s Symposium is “Solar Electricity,” and we are honored to host a star-studded lineup of speakers. These photovoltaic leaders will present life-cycle analyses, report the current state-of- the-art, outline challenges ahead, and propose new ideas to pursue in this rapidly growing field of solar photovoltaic research.
    [Show full text]
  • 25 Years of the Swiss Chemical Society's Division of Analytical
    Columns CHIMIA 2017, 71, No. 12 861 doi:10.2533/chimia.2017.861 Chimia 71 (2017) 861 © Swiss Chemical Society Division of Analytical Sciences A Division of the Swiss Chemical Society 1992–2017: 25 Years of the Swiss Chemical Society’s the fact that its scope is not limited to chemistry but also includes Division of Analytical Sciences – Past, Present and physical techniques and biological methods. Future Activities Walter Giger*, Fritz Erni, and Ernst Halder Membership – Organisation – Communication *Correspondence: Prof. W. Giger, CH-8049 Zurich, E-mail: [email protected] In 1996, almost 300 members of the Swiss Chemical Society were also members of the DAC. By 2017, membership had Keywords: Analytical Sciences · Division of Analytical Sciences increased to 585 (22% of Swiss Chemical Society members). Most of the DAC’s activities were managed and organised by Launch in the 1990s – Scope and Goals – Name therelativelylargeDAC Board,comprisingabout9to17members, several of whom were active for many years. Every other year, In the early 1990s, the chemists’ professional societies in the DAC Board held a retreat, where current endeavours were Switzerland were reorganised. The major event was the merger evaluated and future projects thoroughly discussed and planned. of the Swiss Chemical Society and the Association of Swiss In 1999, the importance of the internet for gaining visibility Chemists in spring 1992. Around the same time, the analytical and meeting members’ needs became evident. Ernst Halder chemists informally organised in the Comité Suisse de Chimie and Käthi Halder initiated and maintained a divisional website Analytique (see CHIMIA 1990, 44(9), 298–299) became the at www.sach.ch, including, most importantly, information on Analytical Chemistry Section (SACh) of the New Swiss Chemical the training programme.
    [Show full text]
  • Recent Progress in Laser Analytics
    KOLUMNE 417 CHIMIA 44 (1990) Nr.I~ (Ikzem""r) Chimia 44 (/990) 417 424 <&') Schll'ei=. Chemiker- Verhand; ISSN 0009 4293 Recent Progress in Laser Analytics Analytical methods are on their way to mass spectrometry (MS). In 1946, William penetrate the biological sciences. In this E. Stephens (University of Pennsylvania in trend, laser technology plays an important Philadelphia) described a mass spectrome- role, especially in the form of laser-desorp- ter with time dispersion, followed by the tion mass spectrometry (LD-MS). ion velocitron of A.E. Cameron and D.£. The remarkable progress made in this Eggers. These devices represented early field is nicely demonstrated by a statement forms of the time-of-flight mass spectrom- made in 1986 by Frank H. Field, a specialist eter (TOF-MS) first described by the Swiss in the mass spectrometric investigation of R. Keller in 1949. biomolecules and Professor at Rockefeller The first commercially successful TOF- University in New York. Citing Professor MS was introduced by Bendix Corpora- In dieser Kalwnne schreibl Field: 'The mass region of real interest for tion, and it was based on the design re- Prof Dr. H. M. Widmer proteins lies between 40000 and 100000 ported in 1955 by William C. Wile)' and Forse/lUng Analylik Da, and one can only speculate as to l. H. McLaren (Bendix Aviation Corpom- Ciha-Geigy AG. FO 3.2 CH 4{)()2 Basel whether such monster gaseos ions could be tion). In these early days of TOF-MS, the regelmiissig eigene Meinungsarlike/ oder liidl Giiste produced. My personal feeling is that to do ions were generated by electron impact ein.
    [Show full text]
  • 2017 WEEKLY BULLETIN DEPARTMENT of CHEMISTRY, NORTHWESTERN UNIVERSITY EVANSTON, ILLINOIS May 15, 2017
    2017 WEEKLY BULLETIN DEPARTMENT OF CHEMISTRY, NORTHWESTERN UNIVERSITY EVANSTON, ILLINOIS May 15, 2017 For full schedule, including Center events, please see the Department Calendar: http://www.chemistry.northwestern.edu/events/calendar.html Tuesday May 16th: Faculty Lunch Seminar: Eric Weitz Tech K140 12:00 – 1:00pm Wednesday May 17th: Chemistry Department Special Seminar: Yogi Surendranath, MIT Tech L211 4:00-5:00pm BIP BIP meets every Friday 10-11:00am in Tech K140 Arrivals We did not have any new arrivals Opportunities Ecolab is the world’s leader in water, hygiene and energy technologies and services that protect people and vital resources. With 2015 sales of $13.5 billion and 47,000 associate, Ecolab’s products and services touch people every day in nearly every corner of the world. We are dedicated to helping our customers achieve their goals by working together to tackle the world’s most pressing and complex challenges – clean water, safe food, abundant energy and healthy environments. Innovation is a cornerstone of Ecolab’s growth. As part of our global Research, Development & Engineering team, you will be inspired by our purpose, to the make the world cleaner, safer and healthier. Join our team of over 1,600 innovators dedicated to helping our customers meet their goals through innovative and effective science, technology, service and insights. Together, we deploy unlimited resourcefulness to help businesses thrive and ensure the availability of the world’s most precious natural resources for future generations. You will work in a collaborative, customer-focused environment where your voice matters, your contributions are rewarded and you can make an impact.
    [Show full text]
  • ©Copyright 2015 Samuel Tabor Marionni Native Ion Mobility Mass Spectrometry: Characterizing Biological Assemblies and Modeling Their Structures
    ©Copyright 2015 Samuel Tabor Marionni Native Ion Mobility Mass Spectrometry: Characterizing Biological Assemblies and Modeling their Structures Samuel Tabor Marionni A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy University of Washington 2015 Reading Committee: Matthew F. Bush, Chair Robert E. Synovec Dustin J. Maly James E. Bruce Program Authorized to Offer Degree: Chemistry University of Washington Abstract Native Ion Mobility Mass Spectrometry: Characterizing Biological Assemblies and Modeling their Structures Samuel Tabor Marionni Chair of the Supervisory Committee: Assistant Professor Matthew F. Bush Department of Chemistry Native mass spectrometry (MS) is an increasingly important structural biology technique for characterizing protein complexes. Conventional structural techniques such as X-ray crys- tallography and nuclear magnetic resonance (NMR) spectroscopy can produce very high- resolution structures, however large quantities of protein are needed, heterogeneity com- plicates structural elucidation, and higher-order complexes of biomolecules are difficult to characterize with these techniques. Native MS is rapid and requires very small amounts of sample. Though the data is not as high-resolution, information about stoichiometry, subunit topology, and ligand-binding, is readily obtained, making native MS very complementary to these techniques. When coupled with ion mobility, geometric information in the form of a collision cross section (Ω) can be obtained as well. Integrative modeling approaches are emerging that integrate gas-phase techniques — such as native MS, ion mobility, chemical cross-linking, and other forms of protein MS — with conventional solution-phase techniques and computational modeling. While conducting the research discussed in this dissertation, I used native MS to investigate two biological systems: a mammalian circadian clock protein complex and a series of engineered fusion proteins.
    [Show full text]
  • TESIS DOCTORAL Determinación De Vapores En Tiempo Real Mediante
    TESIS DOCTORAL PROGRAMA DE DOCTORADO DE QUÍMICA FINA Determinación de vapores en tiempo real mediante ionización secundaria por electrospray (SESI) acoplada a espectrometría de masas: estudios mecanísticos y aplicaciones bioquímicas Real-time determination of vapors by means of secondary electrospray ionization (SESI) coupled to mass spectrometry: mechanistic studies and biochemical applications ALBERTO TEJERO RIOSERAS Directores: Pablo Martínez-Lozano Sinues y Diego García Gómez Tutora: Soledad Rubio Bravo En Córdoba, a 11 de diciembre de 2018 TITULO: Real-time determination of vapors by means of secondary electrospray ionization (SESI) coupled to mass spectrometry: mechanistic studies and biochemical applications AUTOR: Alberto Tejero Rioseras © Edita: UCOPress. 2019 Campus de Rabanales Ctra. Nacional IV, Km. 396 A 14071 Córdoba https://www.uco.es/ucopress/index.php/es/ [email protected] Tesis doctoral Determinación de vapores en tiempo real mediante ionización secundaria por electrospray (SESI) acoplada a espectrometría de masas: estudios mecanísticos y aplicaciones bioquímicas Trabajo presentado para obtener el grado de Doctor por: Alberto Tejero Rioseras, que lo firma en Córdoba, a 11 de diciembre de 2018 Y con el VºBº de: el Director, el Codirector, Pablo Martínez-Lozano Sinues, Diego García Gómez, Assistant Professor at the Department Profesor Ayudante Doctor of Biomedical Engineering, en el Dpto. de Química Analítica University of Basel de la Universidad de Salamanca y la Tutora, Soledad Rubio Bravo Catedrática del Departamento de Química Analítica de la Universidad de Córdoba Mediante la defensa de esta memoria se opta a la obtención de “Doctorado Internacional” dado que se reúnen los siguientes requisitos: 1) El doctorando ha realizado una estancia de 2 años en la Eidgenössische Technische Hochschule Zürich (ETH Zürich) en Suiza donde se ha realizado la formación participando en cursos y conferencias.
    [Show full text]
  • 20Th International Mass Spectrometry Conference
    IMSC 2014 20th International Mass Spectrometry Conference August 24-29, 2014 Geneva, Switzerland PROGRAM v. 17.09.2014 More targets. More accurately. Faster than ever. Analytical challenges grow in quantity and complexity. Quantify a larger number of compounds and more complex analytes faster and more accurately with our new portfolio of LC-MS instruments, sample prep solutions and software. High-resolution, accurate mass solutions using Thermo Scientific™ Orbitrap™ MS quantifies all detectable compounds with high specificity, and triple quadrupole MS delivers SRM sensitivity and speed to detect targeted compounds more quickly. Join us in meeting today’s challenges. Together we’ll transform quantitative science. Quantitation transformed. • Discover more at thermoscientific.com/quan-transformed • Visit thermoscientific.com/imsc or booth 23 for more information © 2014 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are © 2014 Thermo Fisher Scientific Inc. All rights the property of Thermo Fisher Scientific and its subsidiaries. the property Thermo Scientific™ Q Exactive™ HF MS Thermo Scientific™ TSQ Quantiva™ MS Thermo Scientific™ TSQ Endura™ MS Screen and quantify known and unknown targets Leading SRM sensitivity and speed Ultimate SRM quantitative value and with HRAM Orbitrap technology in a triple quadrupole MS/MS unprecedented usability TABLE OF CONTENTS th 1. Welcome from the Chairs of the 20 IMSC ............................................................................................................................
    [Show full text]
  • Microarray-Based Mass Spectrometry for Mammalian Cell Culture Monitoring in Biotechnological Production Processes
    Research Collection Doctoral Thesis Microarray-based mass spectrometry for mammalian cell culture monitoring in biotechnological production processes Author(s): Steinhoff, Robert F. Publication Date: 2016 Permanent Link: https://doi.org/10.3929/ethz-a-010750104 Rights / License: In Copyright - Non-Commercial Use Permitted This page was generated automatically upon download from the ETH Zurich Research Collection. For more information please consult the Terms of use. ETH Library DISS. ETH NO. 23665 Microarray-based mass spectrometry for mammalian cell culture monitoring in biotechnological production processes A thesis submitted to attain the degree of DOCTOR OF SCIENCES of ETH ZURICH (Dr. sc. ETH Zurich) presented by Robert Friedrich Steinhoff M.Sc. in Chemistry, Technical University Munich (TUM) born on 06.05.1985 citizen of Lindau (Bodensee), Germany accepted on the recommendation of Prof. Dr. Renato Zenobi, examiner Prof. Dr. Massimo Morbidelli, co-examiner 2016 ii Acknowledgements Dear reader, The present work on microarray MALDI mass spectrometry has been accomplished in the years 2012 to 2016 at ETH Zurich in the lab of Prof. Zenobi. The excellent infrastructure within ETH Zurich has been the fruitful foundation for this thesis. I am thankful to Prof. Renato Zenobi, who accepted me to work in his lab, firstly as a master student and later as PhD- student within the European Marie Curie initial training network ISOLATE. I am deeply grateful to my parents, my brother, my grandmas, my aunts – hereof especially aunt Gabriela Konietzko who always encouraged and supported me - my uncles, my cousins and their families for their endless understanding and support throughout my education.
    [Show full text]
  • Chemistry Nobel Prize 2002 Goes to Analytical Chemistry
    CHEMISTRY NOBEL PRIZE WINNERS 2002 73 CHIMIA 2003, 57, No. 1/2 Chimia 57 (2003) 73–73 © Schweizerische Chemische Gesellschaft ISSN 0009–4293 Chemistry Nobel Prize 2002 Goes to Analytical Chemistry K. Wüthrich J.B. Fenn K. Tanaka October 2002 was a great month for complexes, the ribosome, or even intact 2nd Japan–China Joint Symposium on Swiss science with Kurt Wüthrich of the viruses by using ESI. Fenn did his original Mass Spectrometry, and published them in ETH Zürich winning the Chemistry Nobel work on ESI while a professor at Yale Uni- 1988 (Rapid Commun. Mass Spectrom. prize 2002. The other half of the 2002 versity in the early 1980s. Coming from the 1988, 2, 151–153). In his original work, Chemistry Nobel prize went jointly to field of molecular beams, he was following Tanaka and his coworkers used a sample John B. Fenn of the Virginia Common- up on earlier (but unsuccessful) work by preparation where the analyte is mixed with wealth University (Richmond, USA) and to Malcolm Dole to produce gas-phase ions ultrafine cobalt powder and glycerol as a Koichi Tanaka of Shimadzu Corp. (Kyoto, from very large molecules. Fenn’s experi- vacuum-stable binding medium. When ir- Japan), who independently developed tech- ence with molecular beam methods helped radiated with a pulse from a low energy ni- niques to ionize large molecules for study him to succeed where the earlier research in trogen laser, the metal particles heat up rap- by mass spectrometry. This recognition for this direction had failed. Because electro- idly, releasing glycerol and intact analyte the development of analytical methods for spray ionization produces multiply charged molecules into the gas phase.
    [Show full text]
  • Nature Milestones Mass Spectrometry October 2015
    October 2015 www.nature.com/milestones/mass-spec MILESTONES Mass Spectrometry Produced with support from: Produced by: Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols MILESTONES Mass Spectrometry MILESTONES COLLECTION 4 Timeline 5 Discovering the power of mass-to-charge (1910 ) NATURE METHODS: COMMENTARY 23 Mass spectrometry in high-throughput 6 Development of ionization methods (1929) proteomics: ready for the big time 7 Isotopes and ancient environments (1939) Tommy Nilsson, Matthias Mann, Ruedi Aebersold, John R Yates III, Amos Bairoch & John J M Bergeron 8 When a velocitron meets a reflectron (1946) 8 Spinning ion trajectories (1949) NATURE: REVIEW Fly out of the traps (1953) 9 28 The biological impact of mass-spectrometry- 10 Breaking down problems (1956) based proteomics 10 Amicable separations (1959) Benjamin F. Cravatt, Gabriel M. Simon & John R. Yates III 11 Solving the primary structure of peptides (1959) 12 A technique to carry a torch for (1961) NATURE: REVIEW 12 The pixelation of mass spectrometry (1962) 38 Metabolic phenotyping in clinical and surgical 13 Conquering carbohydrate complexity (1963) environments Jeremy K. Nicholson, Elaine Holmes, 14 Forming fragments (1966) James M. Kinross, Ara W. Darzi, Zoltan Takats & 14 Seeing the full picture of metabolism (1966) John C. Lindon 15 Electrospray makes molecular elephants fly (1968) 16 Signatures of disease (1975) 16 Reduce complexity by choosing your reactions (1978) 17 Enter the matrix (1985) 18 Dynamic protein structures (1991) 19 Protein discovery goes global (1993) 20 In pursuit of PTMs (1995) 21 Putting the pieces together (1999) CITING THE MILESTONES CONTRIBUTING JOURNALS UK/Europe/ROW (excluding Japan): The Nature Milestones: Mass Spectroscopy supplement has been published as Nature Methods, Nature, Nature Biotechnology, Nature Publishing Group, Subscriptions, a joint project between Nature Methods, Nature, Nature Biotechnology, Nature Chemical Biology and Nature Protocols.
    [Show full text]
  • Maldi Mass Spectrometry for Synthetic Polymer Analysis Chemical Analysis
    MALDI MASS SPECTROMETRY FOR SYNTHETIC POLYMER ANALYSIS CHEMICAL ANALYSIS A SERIES OF MONOGRAPHS ON ANALYTICAL CHEMISTRY AND TTS APPLICATIONS Series Editor J. D. WINEFORDNER Volume 175 A complete list of the titles in this series appears at the end of this volume. MALDI MASS SPECTROMETRY FOR SYNTHETIC POLYMER ANALYSIS EDITED BY LIANG LI WILEY A JOHN WILEY & SONS, INC., PUBLICATION Copyright © 2010 by John Wiley & Sons, Inc. All rights reserved. Published by John Wiley & Sons, Inc., Hoboken, New Jersey. Published simultaneously in Canada. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, (978) 750-8400, fax (978) 750-4470, or on the web at www.copyright.com. Requests to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, (201) 748-6011, fax (201) 748-6088, or online at http://www.wiley.com/go/ permission. Limit of Liability/Disci aimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations of warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose.
    [Show full text]
  • List of Abbreviations
    Ion Mobility Mass Spectrometry of DNA/SgrAI Nuclease Oligomers Item Type text; Electronic Thesis Authors Ma, Xin Publisher The University of Arizona. Rights Copyright © is held by the author. Digital access to this material is made possible by the University Libraries, University of Arizona. Further transmission, reproduction or presentation (such as public display or performance) of protected items is prohibited except with permission of the author. Download date 04/10/2021 07:34:14 Link to Item http://hdl.handle.net/10150/247282 ION MOBILITY MASS SPECTROMETRY OF DNA/SGRAI NUCLEASE OLIGOMERS by Xin Ma ________________________ A Thesis Submitted to the Faculty of the DEPARTMENT OF CHEMISTRY AND BIOCHEMISTRY For the Degree of MASTER OF SCIENCE WITH A MAJOR IN CHEMISTRY In the Graduate College THE UNIVERSITY OF ARIZONA 2012 2 STATEMENT BY AUTHOR This Thesis has been submitted in partial fulfillment of requirements for an advanced degree at the University of Arizona and is deposited in the University Library to be made available to borrowers under rules of the library. Brief quotations from this thesis are allowable without special permission, provided that accurate acknowledge of source is made. Requests for permission for extended quotation from or reproduction of in whole or in part may be granted by the head of the major department or the Dean of the Graduate College when in his or her judgment the proposed use of the material is in the interests of scholarship. In all other instances however, permission must be obtained from the author. Signed:______Xin_Ma________ APPROVAL BY THESIS DIRECTOR This thesis has been approved on the date shown below: ____Vicki H.
    [Show full text]