GLOBAL DRUG FACILITY PRODUCT CATALOGUE

First, second and third line anti-TB medicines

The Global Drug Facility (GDF) aims to ensure the timely delivery of first- and second- line tuberculosis drugs and diagnostics at sustainable prices.

www.stoptb.org/gdf The benefits of GDF quality-assured products

GDF products enable physicians to treat patients according to the latest WHO treatment guidelines. All GDF products are on the WHO Essential Medicines List, which facilitates registration and importation. The use of Fixed Dose Combination (FDC) tablets greatly contributes to rational drug use and assists in effective implementation and expansion of the STOP TB Strategy. FDC tablets reduce the number of tablets a patient needs to take, while avoiding mono-therapy and thereby reduce the risks of developing Multidrug-Resistant TB (MDR-TB).

GDF has adopted standards for blister design which specify the layout, materials, markings and colour coding that should be used. These blister packs offer the same shelf life as loose drugs at similar or lower costs, help health workers identify the drugs needed, provide better protection for the tablets once the container is opened and can be used in all situations and health facilities.

FIRST LINE ANTI-TUBERCULOSIS MEDICINES

Oral solid dosage forms: Fixed Dose Combinations for adults PRODUCT DESCRIPTION PRICE EXW (USD) 4FDC/RHZE 150/75/400/275 Rifampicin 150 mg / Isionazid 75 mg / Pyrazinamide 400 mg / Ethambutol 275 mg film-coated 43.70 (blister) tablets. PvC/Alu film blister pack of 28 tablets x 24 blisters 4FDC/RHZE 150/75/400/275 Rifampicin 150 mg / Isionazid 75 mg / Pyrazinamide 400 mg / Ethambutol 275 mg film-coated 57.29 (loose) tablets. 1000 loose tablets in HDPE container 3FDC/RHE 150/75/275 Rifampicin 150 mg / Isionazid 75 mg / Ethambutol 275 mg film-coated tablets. PvC/Alu film 53.57 (blister) blister pack of 28 tablets x 24 blisters 3FDC/RHE 150/75/275 Rifampicin 150 mg / Isionazid 75 mg / Ethambutol 275 mg film-coated tablets. 1000 loose tablets 77.90 (loose) in HDPE container 2FDC/RH 150/75 Rifampicin 150 mg / Isionazid 75 mg film-coated tablets. PvC/Alu film blister pack of 20.10 (blister) 28 tablets x 24 blisters 2FDC/RH 150/75 Rifampicin 150 mg / Isionazid 75 mg film-coated tablets. 1000 loose tablets in HDPE container 24.92 (loose) 2FDC/EH 400/150 Ethambutol 400 mg / Isionazid 150 mg film-coated tablets. PvC/Alu film blister pack of 28 tablets 20.80 (blister) x 24 blisters

Oral solid dosage forms: Single dose formulations for adults PRODUCT DESCRIPTION PRICE EXW (USD) Ethambutol 400 mg Ethambutol 400mg film-coated tablets. PvC/Alu film blister pack of 28 tablets x 24 blisters 18.30 (blister) Isoniazid 300 mg Isoniazid 300mg film-uncoated tablets. PvC/Alu film blister pack of 28 tablets x 24 blisters 13.52* (blister) Pyrazinamide 400 mg Pyrazinamide 400mg film- uncoated tablets. Alu/PvC film blister pack of 28 tablets x 24 blisters 10.75 (blister) * This price is for indicative purposes. Lower prices may be available following a request for quotations (RFQ) for consolidated orders.

Oral solid dosage forms: Fixed dose combinations for children PRODUCT DESCRIPTION PRICE EXW (USD) 3FDC/RHZ 60/30/150 Rifampicin 60 mg/ Isionazid 30 mg/ Pyrazinamide 150 mg dispersible tablets. 6.00 (blister) PvC/Alu film blister pack of 28 tablets x 3 blisters 2FDC/RH 60/60 Rifampicin 60 mg / Isionazid 60 mg dispersible tablets. PvC/Alu film blister pack of 3.00 (blister) 28 tablets x 3 blisters 2FDC/RH 60/30 Rifampicin 60 mg/Isionazid 30 mg dispersible tablets. PvC/Alu film blister pack of 4.00 (blister) 28 tablets x 3 blisters

Oral solid dosage forms: Single dose formulations for children PRODUCT DESCRIPTION PRICE EXW (USD) Isoniazid 100 mg Isoniazid 100 mg dispersible tablets. PvC/Alu film blister pack of 10 tablets 2.02 (blister) x 10 blisters Ethambutol 100 mg Ethambutol 100 mg dispersible tablets. PvC/Alu film blister pack of 10 tablets 3.26 (blister) x 10 blisters

Parenteral injectables PRODUCT DESCRIPTION PRICE EXW (USD) Streptomycin 1 g inj Streptomycin 1 g powder for injection. 100 vials in a box 68.00 (vial) Pre-shipment inspection is conducted on all orders by an international agency, independent of the manufacturer, to verify the shipment documentation, quantity and integrity of products, labelling and expiry dates. Randomized sampling and testing is conducted by an accredited laboratory to ensure that batches comply with established quality specifications.

GDF is able to achieve very competitive prices for quality assured products through competitive bidding and bulk procurement. Prices listed indicate the base cost of the product and do not include costs for procurement agent fees, quality control, pre-shipment inspection, transport (air freight or sea freight) or insurance. Prices are provided for indicative purposes only and are based on the highest price offered for a product by a contracted supplier. It is noted that for many products, GDF has multiple suppliers and cheaper prices may be available upon a request for quotation, in addition to consolidation of orders and bulk quantity discounts.

SECOND LINE ANTI-TUBERCULOSIS MEDICINES

Oral solid dosage forms: Fluoroquinolones PRODUCT DESCRIPTION PRICE EXW (USD) Ofloxacin 200 mg Ofloxacin 200 mg film-coated tablets. PvC/Alu film blister pack of 10 tablets / 10 blisters 5.00 (blister) in a carton box Ofloxacin 400 mg Ofloxacin 400 mg film-coated tablets. PvC/Alu film blister pack of 10 tablets / 10 blisters 9.00 (blister) in a carton box Levofloxacin 250 mg Levofloxacin 250mg film-coated tablets. PvC/Alu film blister pack of 100 tablets 5.50 (blister) Levofloxacin 500 mg Levofloxacin 500mg film-coated tablets. PvC/Alu film blister pack of 100 tablets 7.85 (blister) Moxifloxacin 400 mg Moxifloxacin 400mg film-coated tablets. PvC/Alu or Alu/Alu film blister pack of 5 tablets 8.40 (blister)

Oral solid dosage forms: Bacteriostatics Second Line Drugs PRODUCT DESCRIPTION PRICE EXW (USD)* Ethionamide 250 mg Ethionamide 250mg film-coated tablets. PvC/Alu and Alu/Alu strips of 10 tablets x 10 blisters 8.25 (blister) in a carton box Prothonamide 250 mg Prothonamide 250mg film-coated tablets. PvC/Alu film blister of 10 tablets x 10 blisters € 10.15 (blister) in a carton box Prothonamide 250 mg 4.07 (loose) Prothonamide 250 mg film-coated tablets. 50 tablets on LPDE bag placed in HDPE container Cycloserine 250 mg Cycloserine 250mg hard capsules. Alu/Alu strip pack of 10 capsules x 10 blisters in a carton box 59.09 (strips) Cycloserine 250 mg Cycloserine 250mg hard capsules. 100 capsules on LPDE bag placed in HDPE container 78.14** (loose-100 caps) PAS Acid P-aminosalycilic acid (PAS) 4 g enteric coated delayed-release granules in sachets. 46.00 (sachets) 30 Alu/PET/Alu/LLDPE sachets in a carton box PAS Sodium P-aminosalicylate sodium salt powder for oral solution 5.52 g sachet. 25 Alu/PET/Alu/LLDPE (powder for oral solution- sachets) laminated sachets / 1 carton box 37.50 PAS Sodium P-aminosalicylate sodium enteric coated delayed-release granules 60% w/w, 100 g HDPE container. (enteric coated granules- container) 100gr in LPDE bag placed in HDPE container 16.00 PAS Sodium P-aminosalicylate sodium enteric coated delayed-release granules 60% w/w, 9.2 g sachets. (enteric coated granules- sachets) 30 PET/Alu/LLDPE sachets of 9.2 g/ 1 carton box 43.50 Terizidone 250 mg Terizidone 250 mg capsules. Alu/PvC blister pack of 10 hard capsules x 5 blisters in a carton box (blister) € 59.00 * Unless otherwise stated ** Procurement of this product is on a case by case basis if countries specifically request this packaging size

Parenteral Injectables PRODUCT DESCRIPTION PRICE EXW (USD) Capreomycin 1 g inj Capreomycin 1 g powder for injection. 1 vial/ampoule in a carton box 8.00 (Powder for injection) Kanamycin 1 gr inj (Solution for injection) Kanamycin 1 g solution for injection (4 ml). 10 vials/ampoules in a carton box 25.8 Amikacin 500 mg inj (Solution for Injection) Amikacin 500mg solution for injection (2 ml). 10 vials/ampoules in a carton box € 7.63 THIRD LINE ANTI-TUBERCULOSIS MEDICINES

PRODUCT DESCRIPTION PRICE EXW (USD) Amoxicilin clavunate 875 + 125 mg Amoxicilin clavunate 875+ 125 mg film coated tablets. PvC/ALU film blister pack of € 3.48 14 tablets in a carton box

STOP TB PATIENT KITS

PRODUCT DESCRIPTION PRICE EXW (USD) Stop TB Cat. I+III Patient Kit A: 6 blisters (168) 4-FDC tablets Cat I & III Kit A (R150/H75/Z400/E275); 12 blisters (336) 2-FDC tablets (R150/H75) 22.30 Stop TB Cat. I+III Patient Kit B: 6 blisters (168) 4-FDCs Cat I & III Kit B (R150/H75/Z400/E275); 18 blisters (504) 2-FDC tablets (E400/H150) 32.27

MEDICAL DEVICES AND WATER FOR INJECTION

PRODUCT DESCRIPTION PRICE EXW (USD) Water for injection 5 ml ampoule Water for injection, sterile, 5 ml plastic ampoules. 100 ampoules in a box 10.60 Hypodermic AD syringes with reuse Hypodermic syringes with automatic disabling (AD) feature, capacity of 5ml, sterile, prevention feature, 5 ml (21G) for reconstitution and injection. 100 pieces in a box 5.75 Hypodermic AD syringes with reuse Hypodermic syringes with automatic disabling (AD) feature, capacity of 5ml, sterile, prevention feature, 5 ml (23G) for reconstitution and injection. 100 pieces in a box 5.75 Safety box for used syringes Safety box for used syringes/needles, 5 lt box of 25 and needles 5lt 17.25

Global Drug Facility Stop TB Partnership c/o World Health Organization 20 Avenue Appia 1211 Geneva 27 Switzerland www.stoptb.org/gdf