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Home , Bordetella hinzii, Pasteurella canis, Pasteurella dagmatis, Pluralibacter gergoviae

® VITEK 2 ID & AST CARDS Reliable • safe • rapid

bioMérieux S.A. • 69280 Marcy l’Étoile • France • Tel.: + 33 (0)4 78 87 20 00 • Fax: +33 (0)4 78 87 20 90 www.biomerieux.com • www.biomerieux-diagnostics.com RESULTS YOU CAN TRUST FOCUS The VITEK 2 ADVANCED EXPERT SYSTEM™ software lets you focus your time where it is most required in the lab. The ADVANCED EXPERT SYSTEM™ validates ON WHAT every result and quickly identi es those truly needing a Microbiologist’s valuable time and attention. This allows the majority of results to be quickly and con dently reported to clinicians without need for MATTERS 2,8,11,13,15 review

EFFICIENCY THROUGH AUTOMATION VITEK 2 cards o er the shortest preparation time in the industry, considerably reducing labor costs1,3,7,9,10,14. They also have the least contaminated waste, o ering up to 64% cost savings for disposal compared to other systems6,10,12.The cards provide increased standardization and automated, same-day results helping clinicians to optimise therapy sooner2,3.

Designed for VITEK 2 automated systems, VITEK 2 identi cation (ID) and susceptibility (AST) cards provide reliable and accurate results for clinically important and yeasts1,2,4,5 ® VITEK 2 ID & AST CARDS Rapid, Flexible, E cient

Each self-contained, disposable test card provides rapid and INNOVATIVE AND FLEXIBLE DESIGN accurate species- level identi cation or • Each card contains microwells with biochemicals or antimicrobials susceptibility results with • Ready and simple to use accurate MICs* based on • Pre-applied barcodes for maximum traceability EUCAST and CLSI compliant AST formulations available reference CLSI** and • ISO *** MIC methods UP TO 50% FEWER PREPARATION STEPS THAN and EUCAST****, OTHER SYSTEMS,3,9,10: US FDA*****, or CLSI® breakpoint • Inoculation with a simple, standardised suspension of organism in saline interpretations1,3,4,5,7,8,10. • No reagent addition

UNIQUE, SAFE, CLOSED CONSUMABLE:

• Optimal for user safety • No aerosols, splattering, or spills • Small, lightweight cards save on contaminated disposal costs and storage space

BROAD AND EXPANDING ID/AST TEST MENU

IDENTIFICATION CARD TYPES ANTIBIOTIC SUSCEPTIBILITY CARD TYPES*

• GN (Gram negative bacilli) 187 organisms • Gram negative Bacilli 78 antimicrobials and ESBL† test • GP (Gram positive cocci & bacilli) 128 organisms • Staphylococci &/or Enterococci 67 antimicrobials, †† • ANC (anaerobes & Corynebacteria) 91 organisms 4 high level screens and ICR test • NH (Neisseria & ) 36 organisms • Streptococci 18 antimicrobials and ICR test and gentamicin synergy • YST (Yeast) 57 organisms • Streptococcus pneumoniae 23 antimicrobials • YST (Yeast) 6 antimicrobials

* Minimum Inhibitory Concentration † Extended-spectrum-beta-lactamase ** Clinical & Laboratory Standards Institute †† Inducible resistance *** International Organization for Standardization **** European Committee on Antimicrobial Susceptibility Testing† Extended-spectrum-beta-lactamase ***** Food and Drug Administration • Roseomonas gilardii • pneumotropica • Gemella bergeri • Salmonella entérica ssp arizonae • Pasteurella testudinis • Gemella haemolysans GRAM NEGATIVE • Salmonella entérica ssp diarizonae • Photobacterium damselae • Gemella morbillorum • Salmonella group (3) • • Gemella sanguinis IDENTIFICATION • Salmonella ser. Gallinarum • Pseudomonas alcaligenes • Globicatella sanguinis VITEK® 2 GN CARD • Salmonella ser. paratyphi A • Pseudomonas fluorescens • Globicatella sulfidifaciens • Salmonella ser. typhi • Pseudomonas luteola • Granulicatella adiacens REF. 21341 • Serratia ficaria • Pseudomonas mendocina • Granulicatella elegans • Serratia fonticola • Pseudomonas oleovorans • Helcococcus kunziii • Serratia liquefaciens group (4) • Pseudomonas oryzihabitans • Kocuria kristinae • • Pseudomonas putida • Kocuria rhizophila • Serratia odorifera • Pseudomonas stutzeri • Kocuria rosea • Serratia plymuthica • Ralstonia insidiosa • Kocuria varians • Budvicia aquatica • Serratia rubidaea • Ralstonia mannitolilytica • Lactococcus garvieae • Buttiauxella agrestis • Shigella group (5) • Ralstonia pickettii • Lactococcus lactis ssp cremoris • Cedecea davisae • • Rhizobium radiobacter • Lactococcus lactis ssp lactis • Cedecea lapagei • Yersinia aldovae • Roseomonas gilardii • Lactococcus raffinolactis • Citrobacter amalonaticus • /frederiksenii • Shewanella algae • Leuconostoc citreum • Citrobacter braakii • Yersinia intermedia • Shewanella putrefaciens • Leuconostoc lactis • Citrobacter farmeri • Yersinia kristensenii • Sphingobacterium multivorum • Leuconostoc mesenteroides ssp. • • • Sphingobacterium spiritivorum cremoris • • Yersinia pseudotuberculosis • Sphingobacterium thalpophilum • Leuconostoc mesenteroides ssp. • Citrobacter sedlakii • Yersinia ruckeri • Sphingomonas paucimobilis dextranicum • Citrobacter youngae • Yokenella regensburgei • Stenotrophomonas maltophilia • Leuconostoc mesenteroides ssp. • Cronobacter sakazakii group (1) • Tatumella ptyseos mesenteroides • Edwardsiella hoshinae • • Leuconostoc pseudomesenteroides NON-ENTEROBACTERIACEAE • Edwardsiella tarda • • Listeria fleischmannii • aerogenes • Achromobacter denitrificans • Vibrio fluvialis • Listeria grayi • Enterobacter asburiae • Achromobacter xylosoxidans • Vibrio metschnikovii • Listeria innocua • Enterobacter cancerogenus • complex (6) • Vibrio mimicus • Listeria ivanovii • complex (2) • Acinetobacter haemolyticus • • Listeria monocytogenes • • Acinetobacter junii • • Listeria rocourtiae • Escherichia coli O157 • Acinetobacter lwoffii • Listeria seeligeri • Escherichia fergusonii • radioresistens HIGHLY PATHOGENIC • Listeria welshimeri • Escherichia hermannii • Actinobacillus ursingii ORGANISMS • Micrococcus luteus • Escherichia vulneris • Actinobacillus ureae • Brucella melitensis • Micrococcus lylae • Ewingella americana • / • • Pediococcus acidilactici • Hafnia alvei Aeromonas caviae • Burkholderia pseudomallei • Pediococcus pentosaceus • Hafnia paralvei • Aeromonas salmonicida • Escherichia coli O157 • Rothia mucilaginosa • • Aeromonas sobria • • Staphylococcus arlettae • • • Yersinia pestis • Staphylococcus aureus ssp ozaenae • Alcaligenes faecalis ssp. faecalis • Staphylococcus auricularis • Klebsiella pneumoniae • bronchiseptica • Staphylococcus capitis ssp pneumoniae • Bordetella hinzii • Staphylococcus caprae • Klebsiella pneumoniae • Bordetella trematum • Staphylococcus carnosus ssp. ssp rhinoscleromatis • Brevundimonas diminuta/vesicularis GRAM POSITIVE carnosus • Kluyvera ascorbata • Brucella melitensis IDENTIFICATION • Staphylococcus chromogenes • Kluyvera cryocrescens • Burkholderia cepacia group (7) • Staphylococcus cohnii ssp. cohnii ® • Kluyvera intermedia • Burkholderia gladioli VITEK 2 GP CARD • Staphylococcus cohnii ssp. urealyticus • Leclercia adecarboxylata • Burkholderia mallei REF. 21342 • Staphylococcus epidermidis • Lelliottia amnigena 1 • Burkholderia pseudomallei • Staphylococcus equorum (Enterobacter amnigenus 1) • Chromobacterium violaceum • Staphylococcus gallinarum • Lelliottia amnigena 2 • Chryseobacterium gleum • Staphylococcus haemolyticus (Enterobacter amnigenus 2) • Chryseobacterium indologenes • Abiotrophia defectiva • Staphylococcus hominis ssp. • Moellerella wisconsensis • Comamonas testosteroni • Aerococcus urinae hominis • Morganella morganii ssp. morganii • Cupriavidus pauculus • Aerococcus viridans • Staphylococcus hominis ssp. • Morganella morganii ssp. sibonii • Delftia acidovorans • Alloiococcus otitis novobiosepticus • Pantoea agglomerans • Elizabethkingia meningoseptica • Dermacoccus nishinomiyaensis / • Staphylococcus hyicus • Pantoea spp. • Francisella tularensis Kytococcus sedentarius • Staphylococcus intermedius • • Grimontia hollisae • Enterococcus avium • Staphylococcus kloosii •  gergoviae • Mannheimia haemolytica • Enterococcus casseliflavus • Staphylococcus lentus (Enterobacter gergoviae) • Methylobacterium spp. • Enterococcus cecorum • Staphylococcus lugdunensis • Proteus hauseri • Moraxella group (8) • Enterococcus columbae • Staphylococcus pseudintermedius • • Myroides spp. • Enterococcus durans • Staphylococcus saprophyticus • Proteus penneri • Neisseria animaloris/zoodegmatis •Enterococcus faecalis • Staphylococcus schleiferi • • Ochrobactrum anthropi • Enterococcus faecium • Staphylococcus sciuri • Providencia alcalifaciens • Oligella ureolytica • Enterococcus gallinarum • Staphylococcus simulans • Providencia rettgeri • Pandoraea spp • Enterococcus hirae • Staphylococcus vitulinus • Providencia rustigianii • Paracoccus yeei • Enterococcus raffinosus • Staphylococcus warneri • Providencia stuartii • Pasteurella aerogenes • Enterococcus saccharolyticus • Staphylcoccus xylosus • Rahnella aquatilis • • Erysipelothrix rhusiopahiae • Streptococcus agalactiae • Raoultella ornithinolytica • • Facklamia hominis • Raoultella planticola • • Gardnerella vaginalis • Streptococcus alactolyticus • Bacteroides fragilis (Propionibacterium propionicus) • Candida glabrata • Streptococcus anginosus • Bacteroides ovatus • Staphylococcus saccharolyticus • Candida guilliermondii • Streptococcus canis • Bacteroides stercoris • Terrisporobacter glycolicus • Candida haemulonii • Streptococcus constellatus ssp. • Bacteroides thetaiotaomicron (Clostridium glycolicum) • Candida haemulonii var vulnera constellatus • Bacteroides uniformis • Trueperella pyogenes • Candida inconspicua / • Streptococcus constellatus ssp. • Bacteroides vulgatus (Arcanobacterium pyogenes) Candida lambica pharyngis • Bifidobacterium spp. • Turicella otitidis • Candida intermedia • Streptococcus cristatus • Campylobacter (Bacteroides) • Veillonella spp. • Candida kefyr • Streptococcus downei ureolyticus • Candida krusei • Streptococcus dysgalactiae ssp. • Clostridium barati • Candida lipolytica dysgalactiae • Clostridium bifermentans • Candida lusitaniae • Streptococcus dysgalactiae ssp. • Clostridium butyricum NEISSERIA • Candida magnoliae equisimilis • Clostridium cadaveris HAEMOPHILUS • Candida norvegensis • Streptococcus equi ssp. equi • Clostridium chauvoei IDENTIFICATION • Candida parapsilosis • Streptococcus equi ssp. zooepidemicus • Clostridium clostridiiforme • Candida pelliculosa • Streptococcus equinus • Clostridium difficile VITEK 2 NH CARD • Candida pulcherrima • Streptococcus gallolyticus ssp. • Clostridium group REF. 21346 • Candida rugosa gallolyticus • Clostridium histolyticum • Candida sake • Streptococcus gallolyticus ssp. • Clostridium paraputrificum • Candida spherica pasteurianus • Clostridium perfringens • Candida tropicalis • Streptococcus gordonii • Clostridium ramosum • Actinobacillus pleuropneumoniae • Candida utilis • Streptococcus hyointestinalis • Clostridium septicum • Actinobacillus suis • Candida zeylanoides • Streptococcus infantarius ssp. coli • Clostridium sordellii • Actinobacillus ureae • Cryptococcus albidus (Str. lutetiensis) • Clostridium sporogenes • Aggregatibacter • Cryptococcus gattii • Streptococcus infantarius ssp. • Clostridium subterminale actinomycetemcomitans • Cryptococcus laurentii infantarius • Clostridium tertium • Aggregatibacter aphrophilus • Cryptococcus neoformans • Streptococcus intermedius • Collinsella aerofaciens • Aggregatibacter segnis • Cryptococcus terreus • Streptococcus iniae • Corynebacterium amycolatum • Campylobacter coli • Cryptococcus uniguttulatus • Streptococcus mitis / • Corynebacterium diphtheriae • Campylobacter fetus ssp. fetus • Geotrichum klebahnii Streptococcus oralis • Corynebacterium jeikeium • ssp. jejuni • Kloeckera spp. • Streptococcus mutans • Corynebacterium minutissimum • Capnocytophaga spp. • Kodamaea ohmeri • Streptococcus ovis • Corynebacterium • • Malassezia furfur • Streptococcus parasanguinis pseudodiphteriticum • • Malassezia pachydermatis • Streptococcus pluranimalium • Corynebacterium striatum • Gardnerella vaginalis • Millerozyma farinosa (Pichia • Streptococcus pneumoniae • Corynebacterium ulcerans • Haemophilus haemolyticus farinosa) • Streptococcus porcinus • Corynebacterium urealyticum • • Prototheca wickerhamii • Streptococcus pseudoporcinus • Eggerthella lenta • Haemophilus parahaemolyticus • Prototheca zopfii • Streptococcus pyogenes • Eggerthella catenaformis • Haemophilus parainfluenzae • Rhodotorula glutinis / • Streptococcus salivarius spp. salivarius (Lactobacillus catenaformis) • Histophilus somni Rhodotorula mucilaginosa • Streptococcus salivarius spp. • Eubacterium limosum • Kingella denitrificans • Rhodotorula minuta thermophilus • Finegoldia magna • • Saccharomyces cerevisiae • Streptococcus sanguinis • Fusobacterium mortiferum • Moraxella (Branhamella) catarrhalis • Saprochaete capitata • Streptococcus sobrinus • Fusobacterium necrophorum • Moraxella (Neisseria) ovis (Geotrichum capitatum) • Streptococcus suis l • Fusobacterium nucleatum • Neisseria cinerea • Sporobolomyces salmonicolor • Streptococcus suis ll • Fusobacterium varium • Neisseria elongata • Trichosporon asahii • Streptococcus thoraltensis • Lactobacillus acidopihlus • • Trichosporon inkin • Streptococcus uberis • Lactobacillus buchneri • Neisseria lactamica • Trichosporon mucoides • Streptococcus vestibularis • Lactobacillus casei • • Zygosaccharomyces spp • Vagococcus fluvialis • Lactobacillus fermentum • Neisseria sicca • Lactobacillus gasseri • Neisseria weaveri 1) Cronobacter genomospecies 1, • Lactobacillus hilgardii • Oligella urethralis • Riemerella anatipestifer Cronobacter dublinensis ssp. dublinensis, • Lactobacillus parabuchneri Cronobacter dublinensis ssp. lausannensis, ANAEROBE • Lactobacillus paracasei • Suttonella indologenes Cronobacter dublinensis ssp. lactaridi, CORYNEBACTERIA • Lactobacillus plantarum Cronobacter malonaticus, Cronobacter • Microbacterium flavescens sakazakii, Cronobacter turicensis, IDENTIFICATION Cronobacter muytjensii • Micobacterium ssp 2) Enterobacter cloacae ssp. cloacae, VITEK 2 ANC CARD • Parabacteroides distasonis YEAST Enterobacter hormaechei, Enterobacter kobei, Enterobacter ludwigii, Enterobacter REF. 21347 • Parabacteroides merdae IDENTIFICATION • Parvimonas micra cloacae ssp. dissolvens 3)  ssp. enterica, • Peptoniphilus asaccharolyticus VITEK 2 YST CARD Salmonella ser. Enteritidis, Salmonella • Peptoniphilus indolicus REF. 21343 ser. Paratyphi B, Salmonella ser. Paratyphi • Actinobaculum schaalii • Peptostreptococcus anaerobius C, Salmonella spp., Salmonella ser. • Actinomyces bovis • Porphyromonas gingivalis Typhimurium 4) Serratia grimesii, Serratia liquefaciens, • Actinomyces israelii • Prevotella bivia Serratia proteamaculans • Actinomyces meyeri • Prevotella buccae • Candida albicans 5), , • Actinomyces naeslundii • Prevotella disiens • Candida auris • Actinomyces neuii • Prevotella denticola • Candida boidinii 6) Acinetobacter baumannii, Acinetobacter • Actinomyces odontolyticus calcoaceticus, Acinetobacter pittii • Prevotella intermedia • Candida catenulata (Acinetobacter genomospecies 3), • Actinomyces turicensis • Prevotella melaninogenica • Candida ciferrii (Stephanoascus ciferrii) Acinetobacter nosocomialis (Acinetobacter • Anaerococcus prevotii • Prevotella oralis • Candida colliculosa genomospecies TU13) • Arcanobacterium haemolyticum • Prevotella oris • Candida dubliniensis 7) Burkholderia cepacia, Burkholderia • Atopobium vaginae • Candida duobushaemulonii multivorans, Burkholderia stabilis, • Propionibacterium acnes Burkholderia vietnamiensis • Bacteroides caccae • Propionibacterium granulosum • Candida famata 8) Moraxella lacunata, Moraxella • Bacteroides eggerthii • Propionibacterium propionicum • Candida freyschussii nonliquefaciens, Moraxella osloensis References ® VITEK 2 ID & AST CARDS • 1 Ayats J., Cisnal M., Lucena J., and Marin R. Analysis of the Impact of Using a VITEK 2 COMPACT® System in a Clinical Microbiology Laboratory: Comparison with the MicroScan WalkAway System®. ASM 2007; Poster C-158. • 2 Barry J., Brown A., Ensor V., Lakhani U., Petts D., Warren C., Winstanley T. Comparative evaluation of the VITEK 2 Advanced Expert System (AES) in five UK hospitals. Reliable • safe • rapid Journal of Antimicrobial Chemotherapy, 2003; 51: 1191–1202. • 3 Blondel-Hill E., Jang W., Lee I., Borton N., Book L., Thomas E. Comparison of Phoenix™ and VITEK® 2 Compact for Performance of Identification and Susceptibility Testing, Workflow, and Time to Report. ICAAC 2006; Poster D-691. • 4 Bobenchik A.M., Deak E., Hindler J.A., Charlton C.L., Humphries R.M. Performance of VITEK®2 for Antimicrobial Susceptibility Testing of Enterobacteriaceae with VITEK® 2 (2009 FDA) and 2014 CLSI Breakpoints. Journal of Clinical Microbiology, 2014; 53(3):816-823. • 5 Bobenchik A.M, Hindler J.A., Giltner C.L., Saeki S., Humphries R.M. Performance of VITEK® 2 for Antimicrobial Susceptibility Testing of Staphylococcus spp. and Enterococcus spp. Journal of Clinical Microbiology, 2014; 52(2):392-397. • 6 Doat V., Roubille M., and Turner R. Analysis of the Comparative Workflow and Accuracy of the VITEK® 2 Compact and the Combination Mini-API®/Agar diffusion SIRSCAN® Method. ECCMID 2007; Poster P-1727. • 7 Eigner U., Schmid A., Wild U., Bertsch D., Fahr A.M. Analysis of the Comparative Workflow and Performance Characteristics of the VITEK 2 and Phoenix Systems. Journal of Clinical Microbiology, 2005; 43(8): 3829–3834. • 8 Galar A., Yuste J.R., Espinosa M., Guillén-Grima F., Hernáez-Crespo S., and Leiva J. Clinical and economic impact of rapid reporting of bacterial identification and antimicrobial susceptibility results of the most frequently processed specimen types. Eur J Clin Microbiol Infect Dis, 2012; 31 (9): 2445-2452. • 9 Heller-Ono A. Ergonomic Analysis Comparison of the VITEK® 2 and VITEK® 2 Compact with the Microscan WalkAway® 96 and Phoenix™ For Work Flow Efficiency and the Likelihood of Distal Upper Extremity Strain. bioMerieux White Paper, 2008. • 10 Hooper M., Hill C., Hadwell V., Blondel-Hill E. Comparison of bioMerieux VITEK 2 XL, BD Phoenix, and Seimens MicroScan Walkaway96 plus choosing an identification and antimicrobial susceptibility testing system for a medium sized microbiology laboratory. ECCMID 2013; Poster P-1536. • 11 LaBombardi V.J. Maximizing the Use of the Advanced Expert System™ to Improve Patient Care. bioMerieux White Paper, 2011. • 12 Larone D.H, Tucci L.J., Samide D.O. Time Study of Three Automated Systems for the Identification and Susceptibility of Bacteria: The MicroScan WalkAway 96, VITEK, and VITEK 2. ASM 2000; Poster C-279. • 13 Livermore DM., Struelens M., Amorim J., Baquero F., Bille J., Canton R., Henning S., Gatermann S., Marchese A., Mittermayer H., Oakton KJ., Praplan F., Ramos H., Schito GC., Van Eldere J., Vaerhaegen J., Verhoef J., and Visser MR. Multicentre evaluation of the VITEK 2 Advanced Expert System for interpretive reading of antimicrobial resistance tests. Journal of Antimicrobial Chemotherapy, 2002; 49 (2): 289–300. • 14 Römmler W., Beer L., Kessler M., and Kaehler K. Analysis of the Comparative Workflow and ID/ AST Test Result Accuracy of the VITEK® 2 compact and the Phoenix™ Systems. ASM 2006; Poster C-123. • 15 Sanders CC., Peyret M., Moland ES., Cavalieri SJ., Shubert C., Thomson KS., Boeufgras JM., and Sanders WE. Potential Impact of the VITEK® 2 System and the Advanced Expert System™ on the Clinical Laboratory of a University-Based Hospital. Journal of Clinical Microbiology, 2001; 39 (7): 2379-2385.

Innovation in microbiology must never stop – because your laboratory challenges never stop. For more than 50 years, bioMérieux has shared your commitment to continually strengthen laboratory impact on patient therapy. For all your testing needs – from the most routine to the truly challenging – our integrated ID/AST* and blood culture o er lets you leverage your expertise to ensure test results that impact timely, appropriate therapy.

*ID/AST: Identi cation and Susceptibility Testing

bioMérieux S.A. • 69280 Marcy l’Étoile • France • Tel.: + 33 (0)4 78 87 20 00 • Fax: +33 (0)4 78 87 20 90

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